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Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T573 0-6 NN denotes Genome
T575 0-82 sentence denotes Genome-wide isolation of growth and obesity QTL using mouse speed congenic strains
T576 6-7 HYPH denotes -
T574 7-11 JJ denotes wide
T577 12-21 NN denotes isolation
T578 22-24 IN denotes of
T579 25-31 NN denotes growth
T581 32-35 CC denotes and
T582 36-43 NN denotes obesity
T580 44-47 NN denotes QTL
T583 48-53 VBG denotes using
T584 54-59 NN denotes mouse
T585 60-65 NN denotes speed
T586 66-74 JJ denotes congenic
T587 75-82 NNS denotes strains
T588 82-83 sentence denotes
T589 93-103 sentence denotes Background
T590 93-103 NN denotes Background
T591 103-318 sentence denotes High growth (hg) modifier and background independent quantitative trait loci (QTL) affecting growth, adiposity and carcass composition were previously identified on mouse chromosomes (MMU) 1, 2, 5, 8, 9, 11 and 17.
T592 104-108 JJ denotes High
T593 109-115 NN denotes growth
T595 116-117 -LRB- denotes (
T596 117-119 NN denotes hg
T597 119-120 -RRB- denotes )
T594 121-129 NN denotes modifier
T599 130-133 CC denotes and
T600 134-144 NN denotes background
T601 145-156 JJ denotes independent
T603 157-169 JJ denotes quantitative
T604 170-175 NN denotes trait
T602 176-180 NNS denotes loci
T605 181-182 -LRB- denotes (
T606 182-185 NN denotes QTL
T607 185-186 -RRB- denotes )
T608 187-196 VBG denotes affecting
T609 197-203 NN denotes growth
T610 203-205 , denotes ,
T611 205-214 NN denotes adiposity
T612 215-218 CC denotes and
T613 219-226 NN denotes carcass
T614 227-238 NN denotes composition
T615 239-243 VBD denotes were
T616 244-254 RB denotes previously
T598 255-265 VBN denotes identified
T617 266-268 IN denotes on
T618 269-274 NN denotes mouse
T619 275-286 NNS denotes chromosomes
T620 287-288 -LRB- denotes (
T621 288-291 NN denotes MMU
T622 291-292 -RRB- denotes )
T623 293-294 CD denotes 1
T624 294-296 , denotes ,
T625 296-297 CD denotes 2
T626 297-299 , denotes ,
T627 299-300 CD denotes 5
T628 300-302 , denotes ,
T629 302-303 CD denotes 8
T630 303-305 , denotes ,
T631 305-306 CD denotes 9
T632 306-308 , denotes ,
T633 308-310 CD denotes 11
T634 311-314 CC denotes and
T635 315-317 CD denotes 17
T636 317-318 . denotes .
T637 318-548 sentence denotes To confirm and further characterize each QTL, two panels of speed congenic strains were developed by introgressing CAST/EiJ (CAST) QTL alleles onto either mutant C57Bl/6J-hg/hg (HG) or wild type C57Bl/6J (B6) genetic backgrounds.
T638 319-321 TO denotes To
T639 322-329 VB denotes confirm
T641 330-333 CC denotes and
T642 334-341 RB denotes further
T643 342-354 VB denotes characterize
T644 355-359 DT denotes each
T645 360-363 NN denotes QTL
T646 363-365 , denotes ,
T647 365-368 CD denotes two
T648 369-375 NNS denotes panels
T649 376-378 IN denotes of
T650 379-384 NN denotes speed
T651 385-393 JJ denotes congenic
T652 394-401 NNS denotes strains
T653 402-406 VBD denotes were
T640 407-416 VBN denotes developed
T654 417-419 IN denotes by
T655 420-433 VBG denotes introgressing
T656 434-438 NN denotes CAST
T658 438-439 HYPH denotes /
T657 439-442 NN denotes EiJ
T660 443-444 -LRB- denotes (
T661 444-448 NN denotes CAST
T662 448-449 -RRB- denotes )
T663 450-453 NN denotes QTL
T659 454-461 NNS denotes alleles
T664 462-466 IN denotes onto
T665 467-473 CC denotes either
T667 474-480 NN denotes mutant
T668 481-486 NN denotes C57Bl
T669 486-487 HYPH denotes /
T670 487-489 NN denotes 6J
T671 489-490 HYPH denotes -
T672 490-492 NN denotes hg
T673 492-493 HYPH denotes /
T666 493-495 NN denotes hg
T675 496-497 -LRB- denotes (
T676 497-499 NN denotes HG
T677 499-500 -RRB- denotes )
T678 501-503 CC denotes or
T679 504-508 JJ denotes wild
T680 509-513 NN denotes type
T681 514-519 NN denotes C57Bl
T683 519-520 HYPH denotes /
T682 520-522 NN denotes 6J
T684 523-524 -LRB- denotes (
T685 524-526 NN denotes B6
T686 526-527 -RRB- denotes )
T687 528-535 JJ denotes genetic
T674 536-547 NNS denotes backgrounds
T688 547-548 . denotes .
T689 548-557 sentence denotes Results
T690 550-557 NNS denotes Results
T691 557-743 sentence denotes The first speed congenic panel was developed by introgressing four overlapping donor regions spanning MMU2 in its entirety onto both HG and B6 backgrounds, for a total of eight strains.
T692 558-561 DT denotes The
T694 562-567 JJ denotes first
T695 568-573 NN denotes speed
T696 574-582 JJ denotes congenic
T693 583-588 NN denotes panel
T698 589-592 VBD denotes was
T697 593-602 VBN denotes developed
T699 603-605 IN denotes by
T700 606-619 VBG denotes introgressing
T701 620-624 CD denotes four
T703 625-636 VBG denotes overlapping
T704 637-642 NN denotes donor
T702 643-650 NNS denotes regions
T705 651-659 VBG denotes spanning
T706 660-664 NN denotes MMU2
T707 665-667 IN denotes in
T708 668-671 PRP$ denotes its
T709 672-680 NN denotes entirety
T710 681-685 IN denotes onto
T711 686-690 CC denotes both
T712 691-693 NN denotes HG
T714 694-697 CC denotes and
T715 698-700 NN denotes B6
T713 701-712 NNS denotes backgrounds
T716 712-714 , denotes ,
T717 714-717 IN denotes for
T718 718-719 DT denotes a
T719 720-725 NN denotes total
T720 726-728 IN denotes of
T721 729-734 CD denotes eight
T722 735-742 NNS denotes strains
T723 742-743 . denotes .
T724 743-940 sentence denotes Phenotypic characterization of the MMU2 panel confirmed the segregation of multiple growth and obesity QTL and strongly suggested that a subset of these loci modify the effects of the hg deletion.
T725 744-754 JJ denotes Phenotypic
T726 755-771 NN denotes characterization
T728 772-774 IN denotes of
T729 775-778 DT denotes the
T731 779-783 NN denotes MMU2
T730 784-789 NN denotes panel
T727 790-799 VBD denotes confirmed
T732 800-803 DT denotes the
T733 804-815 NN denotes segregation
T734 816-818 IN denotes of
T735 819-827 JJ denotes multiple
T736 828-834 NN denotes growth
T738 835-838 CC denotes and
T739 839-846 NN denotes obesity
T737 847-850 NN denotes QTL
T740 851-854 CC denotes and
T741 855-863 RB denotes strongly
T742 864-873 VBD denotes suggested
T743 874-878 IN denotes that
T745 879-880 DT denotes a
T746 881-887 NN denotes subset
T747 888-890 IN denotes of
T748 891-896 DT denotes these
T749 897-901 NNS denotes loci
T744 902-908 VBP denotes modify
T750 909-912 DT denotes the
T751 913-920 NNS denotes effects
T752 921-923 IN denotes of
T753 924-927 DT denotes the
T755 928-930 NN denotes hg
T754 931-939 NN denotes deletion
T756 939-940 . denotes .
T757 940-1057 sentence denotes The second panel consisted of individual donor regions on an HG background for each QTL on MMU1, 5, 8, 9, 11 and 17.
T758 941-944 DT denotes The
T760 945-951 JJ denotes second
T759 952-957 NN denotes panel
T761 958-967 VBD denotes consisted
T762 968-970 IN denotes of
T763 971-981 JJ denotes individual
T765 982-987 NN denotes donor
T764 988-995 NNS denotes regions
T766 996-998 IN denotes on
T767 999-1001 DT denotes an
T769 1002-1004 NN denotes HG
T768 1005-1015 NN denotes background
T770 1016-1019 IN denotes for
T771 1020-1024 DT denotes each
T772 1025-1028 NN denotes QTL
T773 1029-1031 IN denotes on
T774 1032-1035 NN denotes MMU
T775 1035-1036 CD denotes 1
T776 1036-1038 , denotes ,
T777 1038-1039 CD denotes 5
T778 1039-1041 , denotes ,
T779 1041-1042 CD denotes 8
T780 1042-1044 , denotes ,
T781 1044-1045 CD denotes 9
T782 1045-1047 , denotes ,
T783 1047-1049 CD denotes 11
T784 1050-1053 CC denotes and
T785 1054-1056 CD denotes 17
T786 1056-1057 . denotes .
T787 1057-1212 sentence denotes Of the six developed strains, five were successfully characterized and displayed significant differences in growth and/or obesity as compared to controls.
T788 1058-1060 IN denotes Of
T790 1061-1064 DT denotes the
T792 1065-1068 CD denotes six
T793 1069-1078 VBN denotes developed
T791 1079-1086 NNS denotes strains
T794 1086-1088 , denotes ,
T795 1088-1092 CD denotes five
T796 1093-1097 VBD denotes were
T797 1098-1110 RB denotes successfully
T789 1111-1124 VBN denotes characterized
T798 1125-1128 CC denotes and
T799 1129-1138 VBN denotes displayed
T800 1139-1150 JJ denotes significant
T801 1151-1162 NNS denotes differences
T802 1163-1165 IN denotes in
T803 1166-1172 NN denotes growth
T804 1173-1176 CC denotes and
T805 1176-1177 HYPH denotes /
T806 1177-1179 CC denotes or
T807 1180-1187 NN denotes obesity
T808 1188-1190 IN denotes as
T809 1191-1199 VBN denotes compared
T810 1200-1202 IN denotes to
T811 1203-1211 NNS denotes controls
T812 1211-1212 . denotes .
T813 1212-1392 sentence denotes All five displayed phenotypes similar to those originally attributed to each QTL, however, novel phenotypes were unmasked in several of the strains including sex-specific effects.
T814 1213-1216 DT denotes All
T815 1217-1221 CD denotes five
T816 1222-1231 VBD denotes displayed
T818 1232-1242 NNS denotes phenotypes
T819 1243-1250 JJ denotes similar
T820 1251-1253 IN denotes to
T821 1254-1259 DT denotes those
T822 1260-1270 RB denotes originally
T823 1271-1281 VBN denotes attributed
T824 1282-1284 IN denotes to
T825 1285-1289 DT denotes each
T826 1290-1293 NN denotes QTL
T827 1293-1295 , denotes ,
T828 1295-1302 RB denotes however
T829 1302-1304 , denotes ,
T830 1304-1309 JJ denotes novel
T831 1310-1320 NNS denotes phenotypes
T832 1321-1325 VBD denotes were
T817 1326-1334 VBN denotes unmasked
T833 1335-1337 IN denotes in
T834 1338-1345 JJ denotes several
T835 1346-1348 IN denotes of
T836 1349-1352 DT denotes the
T837 1353-1360 NNS denotes strains
T838 1361-1370 VBG denotes including
T839 1371-1374 NN denotes sex
T841 1374-1375 HYPH denotes -
T840 1375-1383 JJ denotes specific
T842 1384-1391 NNS denotes effects
T843 1391-1392 . denotes .
T844 1392-1404 sentence denotes Conclusion
T845 1394-1404 NN denotes Conclusion
T846 1404-1602 sentence denotes The speed congenic strains developed herein constitute an invaluable genomic resource and provide the foundation to identify the specific nature of genetic variation influencing growth and obesity.
T847 1405-1408 DT denotes The
T849 1409-1414 NN denotes speed
T850 1415-1423 JJ denotes congenic
T848 1424-1431 NNS denotes strains
T852 1432-1441 VBN denotes developed
T853 1442-1448 RB denotes herein
T851 1449-1459 VBP denotes constitute
T854 1460-1462 DT denotes an
T856 1463-1473 JJ denotes invaluable
T857 1474-1481 JJ denotes genomic
T855 1482-1490 NN denotes resource
T858 1491-1494 CC denotes and
T859 1495-1502 VBP denotes provide
T860 1503-1506 DT denotes the
T861 1507-1517 NN denotes foundation
T862 1518-1520 TO denotes to
T863 1521-1529 VB denotes identify
T864 1530-1533 DT denotes the
T866 1534-1542 JJ denotes specific
T865 1543-1549 NN denotes nature
T867 1550-1552 IN denotes of
T868 1553-1560 JJ denotes genetic
T869 1561-1570 NN denotes variation
T870 1571-1582 VBG denotes influencing
T871 1583-1589 NN denotes growth
T872 1590-1593 CC denotes and
T873 1594-1601 NN denotes obesity
T874 1601-1602 . denotes .
T2716 1615-1618 DT denotes The
T2717 1619-1622 NN denotes use
T2719 1623-1625 IN denotes of
T2720 1626-1631 NN denotes mouse
T2721 1632-1638 NNS denotes models
T2722 1639-1642 VBZ denotes has
T2718 1643-1651 VBN denotes provided
T2723 1652-1660 JJ denotes valuable
T2724 1661-1668 NN denotes insight
T2725 1669-1673 IN denotes into
T2726 1674-1677 DT denotes the
T2727 1678-1686 NN denotes etiology
T2728 1687-1689 IN denotes of
T2729 1690-1699 JJ denotes monogenic
T2730 1700-1709 NNS denotes syndromes
T2731 1710-1716 VBN denotes caused
T2732 1717-1719 IN denotes by
T2733 1720-1726 JJ denotes single
T2735 1727-1731 NN denotes gene
T2734 1732-1741 NNS denotes mutations
T2736 1741-1742 . denotes .
T2737 1742-1856 sentence denotes However, such models do not mimic the genetic complexity of disease traits commonly seen in the human population.
T2738 1743-1750 RB denotes However
T2740 1750-1752 , denotes ,
T2741 1752-1756 JJ denotes such
T2742 1757-1763 NNS denotes models
T2743 1764-1766 VBP denotes do
T2744 1767-1770 RB denotes not
T2739 1771-1776 VB denotes mimic
T2745 1777-1780 DT denotes the
T2747 1781-1788 JJ denotes genetic
T2746 1789-1799 NN denotes complexity
T2748 1800-1802 IN denotes of
T2749 1803-1810 NN denotes disease
T2750 1811-1817 NNS denotes traits
T2751 1818-1826 RB denotes commonly
T2752 1827-1831 VBN denotes seen
T2753 1832-1834 IN denotes in
T2754 1835-1838 DT denotes the
T2756 1839-1844 JJ denotes human
T2755 1845-1855 NN denotes population
T2757 1855-1856 . denotes .
T2758 1856-2091 sentence denotes Complex traits, such as polygenic growth and obesity are influenced by the small to moderate direct effects of quantitative trait loci (QTL), epistasis between QTL alleles, environmental perturbations and QTL-environment interactions.
T2759 1857-1864 NN denotes Complex
T2760 1865-1871 NNS denotes traits
T2762 1871-1873 , denotes ,
T2763 1873-1877 JJ denotes such
T2764 1878-1880 IN denotes as
T2765 1881-1890 JJ denotes polygenic
T2766 1891-1897 NN denotes growth
T2767 1898-1901 CC denotes and
T2768 1902-1909 NN denotes obesity
T2769 1910-1913 VBP denotes are
T2761 1914-1924 VBN denotes influenced
T2770 1925-1927 IN denotes by
T2771 1928-1931 DT denotes the
T2773 1932-1937 JJ denotes small
T2774 1938-1940 IN denotes to
T2775 1941-1949 JJ denotes moderate
T2776 1950-1956 JJ denotes direct
T2772 1957-1964 NNS denotes effects
T2777 1965-1967 IN denotes of
T2778 1968-1980 JJ denotes quantitative
T2780 1981-1986 NN denotes trait
T2779 1987-1991 NNS denotes loci
T2781 1992-1993 -LRB- denotes (
T2782 1993-1996 NN denotes QTL
T2783 1996-1997 -RRB- denotes )
T2784 1997-1999 , denotes ,
T2785 1999-2008 NN denotes epistasis
T2786 2009-2016 IN denotes between
T2787 2017-2020 NN denotes QTL
T2788 2021-2028 NNS denotes alleles
T2789 2028-2030 , denotes ,
T2790 2030-2043 JJ denotes environmental
T2791 2044-2057 NNS denotes perturbations
T2792 2058-2061 CC denotes and
T2793 2062-2065 NN denotes QTL
T2795 2065-2066 HYPH denotes -
T2794 2066-2077 NN denotes environment
T2796 2078-2090 NNS denotes interactions
T2797 2090-2091 . denotes .
T2798 2091-2274 sentence denotes To date numerous mouse growth and obesity QTL have been localized [1,2], however, little progress has been made in determining the specific nature of the underlying genetic variants.
T2799 2092-2094 IN denotes To
T2801 2095-2099 NN denotes date
T2802 2100-2108 JJ denotes numerous
T2804 2109-2114 NN denotes mouse
T2805 2115-2121 NN denotes growth
T2806 2122-2125 CC denotes and
T2807 2126-2133 NN denotes obesity
T2803 2134-2137 NN denotes QTL
T2808 2138-2142 VBP denotes have
T2809 2143-2147 VBN denotes been
T2800 2148-2157 VBN denotes localized
T2811 2158-2159 -LRB- denotes [
T2813 2159-2160 CD denotes 1
T2814 2160-2161 , denotes ,
T2812 2161-2162 CD denotes 2
T2815 2162-2163 -RRB- denotes ]
T2816 2163-2165 , denotes ,
T2817 2165-2172 RB denotes however
T2818 2172-2174 , denotes ,
T2819 2174-2180 JJ denotes little
T2820 2181-2189 NN denotes progress
T2821 2190-2193 VBZ denotes has
T2822 2194-2198 VBN denotes been
T2810 2199-2203 VBN denotes made
T2823 2204-2206 IN denotes in
T2824 2207-2218 VBG denotes determining
T2825 2219-2222 DT denotes the
T2827 2223-2231 JJ denotes specific
T2826 2232-2238 NN denotes nature
T2828 2239-2241 IN denotes of
T2829 2242-2245 DT denotes the
T2831 2246-2256 VBG denotes underlying
T2832 2257-2264 JJ denotes genetic
T2830 2265-2273 NNS denotes variants
T2833 2273-2274 . denotes .
T2834 2274-2423 sentence denotes One resource used to fine map QTL are congenic strains which are designed to convert a complex polygenic trait into one that is mono- or oligogenic.
T2835 2275-2278 CD denotes One
T2836 2279-2287 NN denotes resource
T2838 2288-2292 VBN denotes used
T2839 2293-2295 TO denotes to
T2841 2296-2300 RB denotes fine
T2840 2301-2304 VB denotes map
T2842 2305-2308 NN denotes QTL
T2837 2309-2312 VBP denotes are
T2843 2313-2321 JJ denotes congenic
T2844 2322-2329 NNS denotes strains
T2845 2330-2335 WDT denotes which
T2847 2336-2339 VBP denotes are
T2846 2340-2348 VBN denotes designed
T2848 2349-2351 TO denotes to
T2849 2352-2359 VB denotes convert
T2850 2360-2361 DT denotes a
T2852 2362-2369 JJ denotes complex
T2853 2370-2379 JJ denotes polygenic
T2851 2380-2385 NN denotes trait
T2854 2386-2390 IN denotes into
T2855 2391-2394 CD denotes one
T2856 2395-2399 WDT denotes that
T2857 2400-2402 VBZ denotes is
T2858 2403-2407 AFX denotes mono
T2860 2407-2408 HYPH denotes -
T2861 2409-2411 CC denotes or
T2859 2412-2422 JJ denotes oligogenic
T2862 2422-2423 . denotes .
T2863 2423-2643 sentence denotes This is accomplished by eliminating segregating genetic variation outside the locus of interest and reducing the environmental variation influencing a trait by characterizing large numbers of genetically identical mice.
T2864 2424-2428 DT denotes This
T2866 2429-2431 VBZ denotes is
T2865 2432-2444 VBN denotes accomplished
T2867 2445-2447 IN denotes by
T2868 2448-2459 VBG denotes eliminating
T2869 2460-2471 VBG denotes segregating
T2870 2472-2479 JJ denotes genetic
T2871 2480-2489 NN denotes variation
T2872 2490-2497 IN denotes outside
T2873 2498-2501 DT denotes the
T2874 2502-2507 NN denotes locus
T2875 2508-2510 IN denotes of
T2876 2511-2519 NN denotes interest
T2877 2520-2523 CC denotes and
T2878 2524-2532 VBG denotes reducing
T2879 2533-2536 DT denotes the
T2881 2537-2550 JJ denotes environmental
T2880 2551-2560 NN denotes variation
T2882 2561-2572 VBG denotes influencing
T2883 2573-2574 DT denotes a
T2884 2575-2580 NN denotes trait
T2885 2581-2583 IN denotes by
T2886 2584-2598 VBG denotes characterizing
T2887 2599-2604 JJ denotes large
T2888 2605-2612 NNS denotes numbers
T2889 2613-2615 IN denotes of
T2890 2616-2627 RB denotes genetically
T2891 2628-2637 JJ denotes identical
T2892 2638-2642 NNS denotes mice
T2893 2642-2643 . denotes .
T2894 2643-2772 sentence denotes The Complex Trait Consortium (CTC) considers congenic analysis an excellent method to confirm and subsequently fine map QTL [3].
T2895 2644-2647 DT denotes The
T2897 2648-2655 NNP denotes Complex
T2898 2656-2661 NNP denotes Trait
T2896 2662-2672 NNP denotes Consortium
T2900 2673-2674 -LRB- denotes (
T2901 2674-2677 NNP denotes CTC
T2902 2677-2678 -RRB- denotes )
T2899 2679-2688 VBZ denotes considers
T2903 2689-2697 JJ denotes congenic
T2904 2698-2706 NN denotes analysis
T2906 2707-2709 DT denotes an
T2907 2710-2719 JJ denotes excellent
T2905 2720-2726 NN denotes method
T2908 2727-2729 TO denotes to
T2909 2730-2737 VB denotes confirm
T2910 2738-2741 CC denotes and
T2911 2742-2754 RB denotes subsequently
T2913 2755-2759 RB denotes fine
T2912 2760-2763 VB denotes map
T2914 2764-2767 NN denotes QTL
T2915 2768-2769 -LRB- denotes [
T2916 2769-2770 CD denotes 3
T2917 2770-2771 -RRB- denotes ]
T2918 2771-2772 . denotes .
T2919 2772-2989 sentence denotes Traditionally, congenic strains are developed by introgressing QTL alleles from a donor strain, whose boundaries are defined by genetic markers, on the genetic background of a recipient strain via 10 backcrosses [4].
T2920 2773-2786 RB denotes Traditionally
T2922 2786-2788 , denotes ,
T2923 2788-2796 JJ denotes congenic
T2924 2797-2804 NNS denotes strains
T2925 2805-2808 VBP denotes are
T2921 2809-2818 VBN denotes developed
T2926 2819-2821 IN denotes by
T2927 2822-2835 VBG denotes introgressing
T2928 2836-2839 NN denotes QTL
T2929 2840-2847 NNS denotes alleles
T2930 2848-2852 IN denotes from
T2931 2853-2854 DT denotes a
T2933 2855-2860 NN denotes donor
T2932 2861-2867 NN denotes strain
T2934 2867-2869 , denotes ,
T2935 2869-2874 WP$ denotes whose
T2936 2875-2885 NNS denotes boundaries
T2938 2886-2889 VBP denotes are
T2937 2890-2897 VBN denotes defined
T2939 2898-2900 IN denotes by
T2940 2901-2908 JJ denotes genetic
T2941 2909-2916 NNS denotes markers
T2942 2916-2918 , denotes ,
T2943 2918-2920 IN denotes on
T2944 2921-2924 DT denotes the
T2946 2925-2932 JJ denotes genetic
T2945 2933-2943 NN denotes background
T2947 2944-2946 IN denotes of
T2948 2947-2948 DT denotes a
T2950 2949-2958 NN denotes recipient
T2949 2959-2965 NN denotes strain
T2951 2966-2969 IN denotes via
T2952 2970-2972 CD denotes 10
T2953 2973-2984 NNS denotes backcrosses
T2954 2985-2986 -LRB- denotes [
T2955 2986-2987 CD denotes 4
T2956 2987-2988 -RRB- denotes ]
T2957 2988-2989 . denotes .
T2958 2989-3111 sentence denotes While technically straightforward this is a time consuming endeavor taking over three years to construct a single strain.
T2959 2990-2995 IN denotes While
T2961 2996-3007 RB denotes technically
T2960 3008-3023 JJ denotes straightforward
T2963 3024-3028 NN denotes this
T2962 3029-3031 VBZ denotes is
T2964 3032-3033 DT denotes a
T2966 3034-3038 NN denotes time
T2967 3039-3048 VBG denotes consuming
T2965 3049-3057 NN denotes endeavor
T2968 3058-3064 VBG denotes taking
T2969 3065-3069 IN denotes over
T2970 3070-3075 CD denotes three
T2971 3076-3081 NNS denotes years
T2972 3082-3084 TO denotes to
T2973 3085-3094 VB denotes construct
T2974 3095-3096 DT denotes a
T2976 3097-3103 JJ denotes single
T2975 3104-3110 NN denotes strain
T2977 3110-3111 . denotes .
T2978 3111-3254 sentence denotes The speed congenic approach is an alternative to this lengthy process and can reduce the number of required backcrosses from 10 to five [5,6].
T2979 3112-3115 DT denotes The
T2981 3116-3121 NN denotes speed
T2982 3122-3130 JJ denotes congenic
T2980 3131-3139 NN denotes approach
T2983 3140-3142 VBZ denotes is
T2984 3143-3145 DT denotes an
T2985 3146-3157 NN denotes alternative
T2986 3158-3160 IN denotes to
T2987 3161-3165 DT denotes this
T2989 3166-3173 JJ denotes lengthy
T2988 3174-3181 NN denotes process
T2990 3182-3185 CC denotes and
T2991 3186-3189 MD denotes can
T2992 3190-3196 VB denotes reduce
T2993 3197-3200 DT denotes the
T2994 3201-3207 NN denotes number
T2995 3208-3210 IN denotes of
T2996 3211-3219 VBN denotes required
T2997 3220-3231 NNS denotes backcrosses
T2998 3232-3236 IN denotes from
T2999 3237-3239 CD denotes 10
T3000 3240-3242 IN denotes to
T3001 3243-3247 CD denotes five
T3002 3248-3249 -LRB- denotes [
T3004 3249-3250 CD denotes 5
T3005 3250-3251 , denotes ,
T3003 3251-3252 CD denotes 6
T3006 3252-3253 -RRB- denotes ]
T3007 3253-3254 . denotes .
T3008 3254-3402 sentence denotes This strategy uses marker-assisted selection to identify male mice inheriting fewer donor alleles, than expected on average, during each backcross.
T3009 3255-3259 DT denotes This
T3010 3260-3268 NN denotes strategy
T3011 3269-3273 VBZ denotes uses
T3012 3274-3280 NN denotes marker
T3014 3280-3281 HYPH denotes -
T3013 3281-3289 VBN denotes assisted
T3015 3290-3299 NN denotes selection
T3016 3300-3302 TO denotes to
T3017 3303-3311 VB denotes identify
T3018 3312-3316 JJ denotes male
T3019 3317-3321 NNS denotes mice
T3020 3322-3332 VBG denotes inheriting
T3021 3333-3338 JJR denotes fewer
T3023 3339-3344 NN denotes donor
T3022 3345-3352 NNS denotes alleles
T3024 3352-3354 , denotes ,
T3025 3354-3358 IN denotes than
T3026 3359-3367 VBN denotes expected
T3027 3368-3370 IN denotes on
T3028 3371-3378 JJ denotes average
T3029 3378-3380 , denotes ,
T3030 3380-3386 IN denotes during
T3031 3387-3391 DT denotes each
T3032 3392-3401 NN denotes backcross
T3033 3401-3402 . denotes .
T3034 3402-3569 sentence denotes Numerous traditionally developed and speed congenics have been used to successfully isolate mouse QTL for a wide array of traits, including growth and obesity [7-13].
T3035 3403-3411 JJ denotes Numerous
T3037 3412-3425 RB denotes traditionally
T3038 3426-3435 VBN denotes developed
T3039 3436-3439 CC denotes and
T3040 3440-3445 NN denotes speed
T3036 3446-3455 NNS denotes congenics
T3042 3456-3460 VBP denotes have
T3043 3461-3465 VBN denotes been
T3041 3466-3470 VBN denotes used
T3044 3471-3473 TO denotes to
T3046 3474-3486 RB denotes successfully
T3045 3487-3494 VB denotes isolate
T3047 3495-3500 NN denotes mouse
T3048 3501-3504 NN denotes QTL
T3049 3505-3508 IN denotes for
T3050 3509-3510 DT denotes a
T3052 3511-3515 JJ denotes wide
T3051 3516-3521 NN denotes array
T3053 3522-3524 IN denotes of
T3054 3525-3531 NNS denotes traits
T3055 3531-3533 , denotes ,
T3056 3533-3542 VBG denotes including
T3057 3543-3549 NN denotes growth
T3058 3550-3553 CC denotes and
T3059 3554-3561 NN denotes obesity
T3060 3562-3563 -LRB- denotes [
T3061 3563-3564 CD denotes 7
T3062 3564-3565 SYM denotes -
T3063 3565-3567 CD denotes 13
T3064 3567-3568 -RRB- denotes ]
T3065 3568-3569 . denotes .
T3066 3569-3773 sentence denotes The C57Bl/6J-hg/hg (HG) mouse is a model of systemic overgrowth resulting from a spontaneous deletion on MMU10, which eliminates expression of the Socs2 (suppressor of cytokine signaling 2) gene [14-16].
T3067 3570-3573 DT denotes The
T3069 3574-3579 NN denotes C57Bl
T3071 3579-3580 HYPH denotes /
T3072 3580-3582 NN denotes 6J
T3073 3582-3583 HYPH denotes -
T3074 3583-3585 NN denotes hg
T3075 3585-3586 HYPH denotes /
T3070 3586-3588 NN denotes hg
T3076 3589-3590 -LRB- denotes (
T3077 3590-3592 NN denotes HG
T3078 3592-3593 -RRB- denotes )
T3068 3594-3599 NN denotes mouse
T3079 3600-3602 VBZ denotes is
T3080 3603-3604 DT denotes a
T3081 3605-3610 NN denotes model
T3082 3611-3613 IN denotes of
T3083 3614-3622 JJ denotes systemic
T3084 3623-3633 NN denotes overgrowth
T3085 3634-3643 VBG denotes resulting
T3086 3644-3648 IN denotes from
T3087 3649-3650 DT denotes a
T3089 3651-3662 JJ denotes spontaneous
T3088 3663-3671 NN denotes deletion
T3090 3672-3674 IN denotes on
T3091 3675-3680 NN denotes MMU10
T3092 3680-3682 , denotes ,
T3093 3682-3687 WDT denotes which
T3094 3688-3698 VBZ denotes eliminates
T3095 3699-3709 NN denotes expression
T3096 3710-3712 IN denotes of
T3097 3713-3716 DT denotes the
T3099 3717-3722 NN denotes Socs2
T3100 3723-3724 -LRB- denotes (
T3101 3724-3734 NN denotes suppressor
T3102 3735-3737 IN denotes of
T3103 3738-3746 NN denotes cytokine
T3104 3747-3756 NN denotes signaling
T3105 3757-3758 CD denotes 2
T3106 3758-3759 -RRB- denotes )
T3098 3760-3764 NN denotes gene
T3107 3765-3766 -LRB- denotes [
T3108 3766-3768 CD denotes 14
T3109 3768-3769 SYM denotes -
T3110 3769-3771 CD denotes 16
T3111 3771-3772 -RRB- denotes ]
T3112 3772-3773 . denotes .
T3113 3773-3961 sentence denotes The role of Socs2 in the HG phenotype was confirmed by an independently engineered Socs2-/- knockout mouse which shared a number of phenotypes in common with HG, including gigantism [17].
T3114 3774-3777 DT denotes The
T3115 3778-3782 NN denotes role
T3117 3783-3785 IN denotes of
T3118 3786-3791 NN denotes Socs2
T3119 3792-3794 IN denotes in
T3120 3795-3798 DT denotes the
T3122 3799-3801 NN denotes HG
T3121 3802-3811 NN denotes phenotype
T3123 3812-3815 VBD denotes was
T3116 3816-3825 VBN denotes confirmed
T3124 3826-3828 IN denotes by
T3125 3829-3831 DT denotes an
T3127 3832-3845 RB denotes independently
T3128 3846-3856 VBN denotes engineered
T3129 3857-3862 NN denotes Socs2
T3131 3862-3863 SYM denotes -
T3132 3863-3864 HYPH denotes /
T3133 3864-3865 SYM denotes -
T3130 3866-3874 NN denotes knockout
T3126 3875-3880 NN denotes mouse
T3134 3881-3886 WDT denotes which
T3135 3887-3893 VBD denotes shared
T3136 3894-3895 DT denotes a
T3137 3896-3902 NN denotes number
T3138 3903-3905 IN denotes of
T3139 3906-3916 NNS denotes phenotypes
T3140 3917-3919 IN denotes in
T3141 3920-3926 NN denotes common
T3142 3927-3931 IN denotes with
T3143 3932-3934 NN denotes HG
T3144 3934-3936 , denotes ,
T3145 3936-3945 VBG denotes including
T3146 3946-3955 NN denotes gigantism
T3147 3956-3957 -LRB- denotes [
T3148 3957-3959 CD denotes 17
T3149 3959-3960 -RRB- denotes ]
T3150 3960-3961 . denotes .
T3151 3961-4055 sentence denotes QTL which alter the phenotypic effects of another locus are referred to as modifier QTL [18].
T3152 3962-3965 NN denotes QTL
T3154 3966-3971 WDT denotes which
T3155 3972-3977 VBP denotes alter
T3156 3978-3981 DT denotes the
T3158 3982-3992 JJ denotes phenotypic
T3157 3993-4000 NNS denotes effects
T3159 4001-4003 IN denotes of
T3160 4004-4011 DT denotes another
T3161 4012-4017 NN denotes locus
T3162 4018-4021 VBP denotes are
T3153 4022-4030 VBN denotes referred
T3163 4031-4033 IN denotes to
T3164 4034-4036 IN denotes as
T3165 4037-4045 NN denotes modifier
T3166 4046-4049 NN denotes QTL
T3167 4050-4051 -LRB- denotes [
T3168 4051-4053 CD denotes 18
T3169 4053-4054 -RRB- denotes ]
T3170 4054-4055 . denotes .
T3171 4055-4282 sentence denotes Modifier QTL have been mapped for numerous traits and in these studies the modified locus is typically a known gene containing a spontaneously arisen or engineered mutation with major phenotypic effects, such as hg [11,19-21].
T3172 4056-4064 NN denotes Modifier
T3173 4065-4068 NN denotes QTL
T3175 4069-4073 VBP denotes have
T3176 4074-4078 VBN denotes been
T3174 4079-4085 VBN denotes mapped
T3177 4086-4089 IN denotes for
T3178 4090-4098 JJ denotes numerous
T3179 4099-4105 NNS denotes traits
T3180 4106-4109 CC denotes and
T3181 4110-4112 IN denotes in
T3183 4113-4118 DT denotes these
T3184 4119-4126 NNS denotes studies
T3185 4127-4130 DT denotes the
T3187 4131-4139 VBN denotes modified
T3186 4140-4145 NN denotes locus
T3182 4146-4148 VBZ denotes is
T3188 4149-4158 RB denotes typically
T3189 4159-4160 DT denotes a
T3191 4161-4166 VBN denotes known
T3190 4167-4171 NN denotes gene
T3192 4172-4182 VBG denotes containing
T3193 4183-4184 DT denotes a
T3195 4185-4198 RB denotes spontaneously
T3196 4199-4205 VBN denotes arisen
T3197 4206-4208 CC denotes or
T3198 4209-4219 VBN denotes engineered
T3194 4220-4228 NN denotes mutation
T3199 4229-4233 IN denotes with
T3200 4234-4239 JJ denotes major
T3202 4240-4250 JJ denotes phenotypic
T3201 4251-4258 NNS denotes effects
T3203 4258-4260 , denotes ,
T3204 4260-4264 JJ denotes such
T3205 4265-4267 IN denotes as
T3206 4268-4270 NN denotes hg
T3207 4271-4272 -LRB- denotes [
T3208 4272-4274 CD denotes 11
T3209 4274-4275 , denotes ,
T3210 4275-4277 CD denotes 19
T3211 4277-4278 SYM denotes -
T3212 4278-4280 CD denotes 21
T3213 4280-4281 -RRB- denotes ]
T3214 4281-4282 . denotes .
T3215 4282-4436 sentence denotes Epistasis forms the basis of these interactions, implying that the known gene and its modifiers are members of the same biochemical or metabolic pathway.
T3216 4283-4292 NN denotes Epistasis
T3217 4293-4298 VBZ denotes forms
T3218 4299-4302 DT denotes the
T3219 4303-4308 NN denotes basis
T3220 4309-4311 IN denotes of
T3221 4312-4317 DT denotes these
T3222 4318-4330 NNS denotes interactions
T3223 4330-4332 , denotes ,
T3224 4332-4340 VBG denotes implying
T3225 4341-4345 IN denotes that
T3227 4346-4349 DT denotes the
T3229 4350-4355 VBN denotes known
T3228 4356-4360 NN denotes gene
T3230 4361-4364 CC denotes and
T3231 4365-4368 PRP$ denotes its
T3232 4369-4378 NNS denotes modifiers
T3226 4379-4382 VBP denotes are
T3233 4383-4390 NNS denotes members
T3234 4391-4393 IN denotes of
T3235 4394-4397 DT denotes the
T3237 4398-4402 JJ denotes same
T3238 4403-4414 JJ denotes biochemical
T3239 4415-4417 CC denotes or
T3240 4418-4427 JJ denotes metabolic
T3236 4428-4435 NN denotes pathway
T3241 4435-4436 . denotes .
T3242 4436-4536 sentence denotes Different genetic backgrounds have been shown to modify the growth-enhancing effects of hg [15,22].
T3243 4437-4446 JJ denotes Different
T3245 4447-4454 JJ denotes genetic
T3244 4455-4466 NNS denotes backgrounds
T3247 4467-4471 VBP denotes have
T3248 4472-4476 VBN denotes been
T3246 4477-4482 VBN denotes shown
T3249 4483-4485 TO denotes to
T3250 4486-4492 VB denotes modify
T3251 4493-4496 DT denotes the
T3253 4497-4503 NN denotes growth
T3255 4503-4504 HYPH denotes -
T3254 4504-4513 VBG denotes enhancing
T3252 4514-4521 NNS denotes effects
T3256 4522-4524 IN denotes of
T3257 4525-4527 NN denotes hg
T3258 4528-4529 -LRB- denotes [
T3260 4529-4531 CD denotes 15
T3261 4531-4532 , denotes ,
T3259 4532-4534 CD denotes 22
T3262 4534-4535 -RRB- denotes ]
T3263 4535-4536 . denotes .
T3264 4536-4763 sentence denotes Since the primary function of Socs2 is to negatively regulate growth hormone (Gh) [23], it is likely these background effects are the result of polymorphism influencing interactions between members of the Gh signaling pathway.
T3265 4537-4542 IN denotes Since
T3267 4543-4546 DT denotes the
T3269 4547-4554 JJ denotes primary
T3268 4555-4563 NN denotes function
T3270 4564-4566 IN denotes of
T3271 4567-4572 NN denotes Socs2
T3266 4573-4575 VBZ denotes is
T3273 4576-4578 TO denotes to
T3275 4579-4589 RB denotes negatively
T3274 4590-4598 VB denotes regulate
T3276 4599-4605 NN denotes growth
T3277 4606-4613 NN denotes hormone
T3278 4614-4615 -LRB- denotes (
T3279 4615-4617 NN denotes Gh
T3280 4617-4618 -RRB- denotes )
T3281 4619-4620 -LRB- denotes [
T3282 4620-4622 CD denotes 23
T3283 4622-4623 -RRB- denotes ]
T3284 4623-4625 , denotes ,
T3285 4625-4627 PRP denotes it
T3272 4628-4630 VBZ denotes is
T3286 4631-4637 JJ denotes likely
T3287 4638-4643 DT denotes these
T3289 4644-4654 NN denotes background
T3288 4655-4662 NNS denotes effects
T3290 4663-4666 VBP denotes are
T3291 4667-4670 DT denotes the
T3292 4671-4677 NN denotes result
T3293 4678-4680 IN denotes of
T3294 4681-4693 NN denotes polymorphism
T3295 4694-4705 VBG denotes influencing
T3296 4706-4718 NNS denotes interactions
T3297 4719-4726 IN denotes between
T3298 4727-4734 NNS denotes members
T3299 4735-4737 IN denotes of
T3300 4738-4741 DT denotes the
T3302 4742-4744 NN denotes Gh
T3303 4745-4754 NN denotes signaling
T3301 4755-4762 NN denotes pathway
T3304 4762-4763 . denotes .
T3305 4763-4932 sentence denotes Thus, identification of hg modifiers has the potential to uncover novel members of metabolically important pathways or previously unknown convergences between pathways.
T3306 4764-4768 RB denotes Thus
T3308 4768-4770 , denotes ,
T3309 4770-4784 NN denotes identification
T3310 4785-4787 IN denotes of
T3311 4788-4790 NN denotes hg
T3312 4791-4800 NNS denotes modifiers
T3307 4801-4804 VBZ denotes has
T3313 4805-4808 DT denotes the
T3314 4809-4818 NN denotes potential
T3315 4819-4821 TO denotes to
T3316 4822-4829 VB denotes uncover
T3317 4830-4835 JJ denotes novel
T3318 4836-4843 NNS denotes members
T3319 4844-4846 IN denotes of
T3320 4847-4860 RB denotes metabolically
T3321 4861-4870 JJ denotes important
T3322 4871-4879 NNS denotes pathways
T3323 4880-4882 CC denotes or
T3324 4883-4893 RB denotes previously
T3325 4894-4901 JJ denotes unknown
T3326 4902-4914 NNS denotes convergences
T3327 4915-4922 IN denotes between
T3328 4923-4931 NNS denotes pathways
T3329 4931-4932 . denotes .
T3330 4932-5051 sentence denotes As an initial step, growth and carcass composition QTL were identified in a cross between CAST/EiJ (CAST) and HG [24].
T3331 4933-4935 IN denotes As
T3333 4936-4938 DT denotes an
T3335 4939-4946 JJ denotes initial
T3334 4947-4951 NN denotes step
T3336 4951-4953 , denotes ,
T3337 4953-4959 NN denotes growth
T3339 4960-4963 CC denotes and
T3340 4964-4971 NN denotes carcass
T3341 4972-4983 NN denotes composition
T3338 4984-4987 NN denotes QTL
T3342 4988-4992 VBD denotes were
T3332 4993-5003 VBN denotes identified
T3343 5004-5006 IN denotes in
T3344 5007-5008 DT denotes a
T3345 5009-5014 NN denotes cross
T3346 5015-5022 IN denotes between
T3347 5023-5027 NN denotes CAST
T3349 5027-5028 HYPH denotes /
T3348 5028-5031 NN denotes EiJ
T3350 5032-5033 -LRB- denotes (
T3351 5033-5037 NN denotes CAST
T3352 5037-5038 -RRB- denotes )
T3353 5039-5042 CC denotes and
T3354 5043-5045 NN denotes HG
T3355 5046-5047 -LRB- denotes [
T3356 5047-5049 CD denotes 24
T3357 5049-5050 -RRB- denotes ]
T3358 5050-5051 . denotes .
T3359 5051-5290 sentence denotes In the F2, mice homozygous for the hg deletion (hg/hg) and wild type (+/+) were assayed and hg modifier QTL were defined as those either absent in +/+ mice and segregating in hg/hg or loci with altered gene action dependent on background.
T3360 5052-5054 IN denotes In
T3362 5055-5058 DT denotes the
T3363 5059-5061 NN denotes F2
T3364 5061-5063 , denotes ,
T3365 5063-5067 NNS denotes mice
T3366 5068-5078 JJ denotes homozygous
T3367 5079-5082 IN denotes for
T3368 5083-5086 DT denotes the
T3370 5087-5089 NN denotes hg
T3369 5090-5098 NN denotes deletion
T3371 5099-5100 -LRB- denotes (
T3373 5100-5102 NN denotes hg
T3374 5102-5103 HYPH denotes /
T3372 5103-5105 NN denotes hg
T3375 5105-5106 -RRB- denotes )
T3376 5107-5110 CC denotes and
T3377 5111-5115 JJ denotes wild
T3378 5116-5120 NN denotes type
T3379 5121-5122 -LRB- denotes (
T3380 5122-5123 SYM denotes +
T3382 5123-5124 HYPH denotes /
T3381 5124-5125 SYM denotes +
T3383 5125-5126 -RRB- denotes )
T3384 5127-5131 VBD denotes were
T3361 5132-5139 VBN denotes assayed
T3385 5140-5143 CC denotes and
T3386 5144-5146 NN denotes hg
T3387 5147-5155 NN denotes modifier
T3388 5156-5159 NN denotes QTL
T3390 5160-5164 VBD denotes were
T3389 5165-5172 VBN denotes defined
T3391 5173-5175 IN denotes as
T3392 5176-5181 DT denotes those
T3393 5182-5188 CC denotes either
T3394 5189-5195 JJ denotes absent
T3395 5196-5198 IN denotes in
T3396 5199-5200 SYM denotes +
T3398 5200-5201 HYPH denotes /
T3397 5201-5202 SYM denotes +
T3399 5203-5207 NNS denotes mice
T3400 5208-5211 CC denotes and
T3401 5212-5223 VBG denotes segregating
T3402 5224-5226 IN denotes in
T3403 5227-5229 NN denotes hg
T3405 5229-5230 HYPH denotes /
T3404 5230-5232 NN denotes hg
T3406 5233-5235 CC denotes or
T3407 5236-5240 NNS denotes loci
T3408 5241-5245 IN denotes with
T3409 5246-5253 VBN denotes altered
T3411 5254-5258 NN denotes gene
T3410 5259-5265 NN denotes action
T3412 5266-5275 JJ denotes dependent
T3413 5276-5278 IN denotes on
T3414 5279-5289 NN denotes background
T3415 5289-5290 . denotes .
T3416 5290-5693 sentence denotes Four hg modifier QTL (Wg2 on MMU2, Carfhg2 on MMU9, Carp2 on MMU11 and Feml3 on MMU17) were identified, along with 12 additional QTL (Q1Ucd1 on MMU1 (which only reached a suggestive level of statistical significance), Wg1, Carp1, Cara1 and Feml1 on MMU2, Carfhg1 on MMU5, Wg3 on MMU8, Feml2 on MMU9, Wg4 and Cara2 on MMU11 and Carp3 and Cara3 on MMU17) whose expression was independent of the hg locus.
T3417 5291-5295 CD denotes Four
T3418 5296-5298 NN denotes hg
T3420 5299-5307 NN denotes modifier
T3419 5308-5311 NN denotes QTL
T3422 5312-5313 -LRB- denotes (
T3423 5313-5316 NN denotes Wg2
T3424 5317-5319 IN denotes on
T3425 5320-5324 NN denotes MMU2
T3426 5324-5326 , denotes ,
T3427 5326-5333 NN denotes Carfhg2
T3428 5334-5336 IN denotes on
T3429 5337-5341 NN denotes MMU9
T3430 5341-5343 , denotes ,
T3431 5343-5348 NN denotes Carp2
T3432 5349-5351 IN denotes on
T3433 5352-5357 NN denotes MMU11
T3434 5358-5361 CC denotes and
T3435 5362-5367 NN denotes Feml3
T3436 5368-5370 IN denotes on
T3437 5371-5376 NN denotes MMU17
T3438 5376-5377 -RRB- denotes )
T3439 5378-5382 VBD denotes were
T3421 5383-5393 VBN denotes identified
T3440 5393-5395 , denotes ,
T3441 5395-5400 IN denotes along
T3442 5401-5405 IN denotes with
T3443 5406-5408 CD denotes 12
T3445 5409-5419 JJ denotes additional
T3444 5420-5423 NN denotes QTL
T3446 5424-5425 -LRB- denotes (
T3447 5425-5431 NN denotes Q1Ucd1
T3448 5432-5434 IN denotes on
T3449 5435-5439 NN denotes MMU1
T3450 5440-5441 -LRB- denotes (
T3451 5441-5446 WDT denotes which
T3453 5447-5451 RB denotes only
T3452 5452-5459 VBD denotes reached
T3454 5460-5461 DT denotes a
T3456 5462-5472 JJ denotes suggestive
T3455 5473-5478 NN denotes level
T3457 5479-5481 IN denotes of
T3458 5482-5493 JJ denotes statistical
T3459 5494-5506 NN denotes significance
T3460 5506-5507 -RRB- denotes )
T3461 5507-5509 , denotes ,
T3462 5509-5512 NN denotes Wg1
T3463 5512-5514 , denotes ,
T3464 5514-5519 NN denotes Carp1
T3465 5519-5521 , denotes ,
T3466 5521-5526 NN denotes Cara1
T3467 5527-5530 CC denotes and
T3468 5531-5536 NN denotes Feml1
T3469 5537-5539 IN denotes on
T3470 5540-5544 NN denotes MMU2
T3471 5544-5546 , denotes ,
T3472 5546-5553 NN denotes Carfhg1
T3473 5554-5556 IN denotes on
T3474 5557-5561 NN denotes MMU5
T3475 5561-5563 , denotes ,
T3476 5563-5566 NN denotes Wg3
T3477 5567-5569 IN denotes on
T3478 5570-5574 NN denotes MMU8
T3479 5574-5576 , denotes ,
T3480 5576-5581 NN denotes Feml2
T3481 5582-5584 IN denotes on
T3482 5585-5589 NN denotes MMU9
T3483 5589-5591 , denotes ,
T3484 5591-5594 NN denotes Wg4
T3485 5595-5598 CC denotes and
T3486 5599-5604 NN denotes Cara2
T3487 5605-5607 IN denotes on
T3488 5608-5613 NN denotes MMU11
T3489 5614-5617 CC denotes and
T3490 5618-5623 NN denotes Carp3
T3491 5624-5627 CC denotes and
T3492 5628-5633 NN denotes Cara3
T3493 5634-5636 IN denotes on
T3494 5637-5642 NN denotes MMU17
T3495 5642-5643 -RRB- denotes )
T3496 5644-5649 WP$ denotes whose
T3497 5650-5660 NN denotes expression
T3498 5661-5664 VBD denotes was
T3499 5665-5676 JJ denotes independent
T3500 5677-5679 IN denotes of
T3501 5680-5683 DT denotes the
T3503 5684-5686 NN denotes hg
T3502 5687-5692 NN denotes locus
T3504 5692-5693 . denotes .
T3505 5693-5794 sentence denotes In the current study we have developed speed congenic strains to isolate all the aforementioned QTL.
T3506 5694-5696 IN denotes In
T3508 5697-5700 DT denotes the
T3510 5701-5708 JJ denotes current
T3509 5709-5714 NN denotes study
T3511 5715-5717 PRP denotes we
T3512 5718-5722 VBP denotes have
T3507 5723-5732 VBN denotes developed
T3513 5733-5738 NN denotes speed
T3514 5739-5747 JJ denotes congenic
T3515 5748-5755 NNS denotes strains
T3516 5756-5758 TO denotes to
T3517 5759-5766 VB denotes isolate
T3518 5767-5770 PDT denotes all
T3520 5771-5774 DT denotes the
T3521 5775-5789 JJ denotes aforementioned
T3519 5790-5793 NN denotes QTL
T3522 5793-5794 . denotes .
T3523 5794-6022 sentence denotes Single strains on an HG background were created for each chromosomal region outside of MMU2, while a comprehensive panel of overlapping strains with identical donor regions on both B6 and HG backgrounds were developed for MMU2.
T3524 5795-5801 JJ denotes Single
T3525 5802-5809 NNS denotes strains
T3527 5810-5812 IN denotes on
T3528 5813-5815 DT denotes an
T3530 5816-5818 NN denotes HG
T3529 5819-5829 NN denotes background
T3531 5830-5834 VBD denotes were
T3526 5835-5842 VBN denotes created
T3532 5843-5846 IN denotes for
T3533 5847-5851 DT denotes each
T3535 5852-5863 JJ denotes chromosomal
T3534 5864-5870 NN denotes region
T3536 5871-5878 IN denotes outside
T3537 5879-5881 IN denotes of
T3538 5882-5886 NN denotes MMU2
T3539 5886-5888 , denotes ,
T3540 5888-5893 IN denotes while
T3542 5894-5895 DT denotes a
T3544 5896-5909 JJ denotes comprehensive
T3543 5910-5915 NN denotes panel
T3545 5916-5918 IN denotes of
T3546 5919-5930 VBG denotes overlapping
T3547 5931-5938 NNS denotes strains
T3548 5939-5943 IN denotes with
T3549 5944-5953 JJ denotes identical
T3551 5954-5959 NN denotes donor
T3550 5960-5967 NNS denotes regions
T3552 5968-5970 IN denotes on
T3553 5971-5975 CC denotes both
T3554 5976-5978 NN denotes B6
T3556 5979-5982 CC denotes and
T3557 5983-5985 NN denotes HG
T3555 5986-5997 NNS denotes backgrounds
T3558 5998-6002 VBD denotes were
T3541 6003-6012 VBN denotes developed
T3559 6013-6016 IN denotes for
T3560 6017-6021 NN denotes MMU2
T3561 6021-6022 . denotes .
T3562 6022-6125 sentence denotes The MMU2 panel was developed to confirm the presence of multiple QTL and test for QTL-hg interactions.
T3563 6023-6026 DT denotes The
T3565 6027-6031 NN denotes MMU2
T3564 6032-6037 NN denotes panel
T3567 6038-6041 VBD denotes was
T3566 6042-6051 VBN denotes developed
T3568 6052-6054 TO denotes to
T3569 6055-6062 VB denotes confirm
T3570 6063-6066 DT denotes the
T3571 6067-6075 NN denotes presence
T3572 6076-6078 IN denotes of
T3573 6079-6087 JJ denotes multiple
T3574 6088-6091 NN denotes QTL
T3575 6092-6095 CC denotes and
T3576 6096-6100 VB denotes test
T3577 6101-6104 IN denotes for
T3578 6105-6108 NN denotes QTL
T3580 6108-6109 HYPH denotes -
T3579 6109-6111 NN denotes hg
T3581 6112-6124 NNS denotes interactions
T3582 6124-6125 . denotes .
T3583 6125-6317 sentence denotes Additionally, based on the knowledge of potential QTL-hg interactions, genes involved in Gh signaling, whose genomic location overlapped hg modifier QTL on MMU2, 9, 11 and 17, were sequenced.
T3584 6126-6138 RB denotes Additionally
T3586 6138-6140 , denotes ,
T3587 6140-6145 VBN denotes based
T3588 6146-6148 IN denotes on
T3589 6149-6152 DT denotes the
T3590 6153-6162 NN denotes knowledge
T3591 6163-6165 IN denotes of
T3592 6166-6175 JJ denotes potential
T3594 6176-6179 NN denotes QTL
T3596 6179-6180 HYPH denotes -
T3595 6180-6182 NN denotes hg
T3593 6183-6195 NNS denotes interactions
T3597 6195-6197 , denotes ,
T3598 6197-6202 NNS denotes genes
T3599 6203-6211 VBN denotes involved
T3600 6212-6214 IN denotes in
T3601 6215-6217 NN denotes Gh
T3602 6218-6227 NN denotes signaling
T3603 6227-6229 , denotes ,
T3604 6229-6234 WP$ denotes whose
T3606 6235-6242 JJ denotes genomic
T3605 6243-6251 NN denotes location
T3607 6252-6262 VBD denotes overlapped
T3608 6263-6265 NN denotes hg
T3610 6266-6274 NN denotes modifier
T3609 6275-6278 NN denotes QTL
T3611 6279-6281 IN denotes on
T3612 6282-6285 NN denotes MMU
T3613 6285-6286 CD denotes 2
T3614 6286-6288 , denotes ,
T3615 6288-6289 CD denotes 9
T3616 6289-6291 , denotes ,
T3617 6291-6293 CD denotes 11
T3618 6294-6297 CC denotes and
T3619 6298-6300 CD denotes 17
T3620 6300-6302 , denotes ,
T3621 6302-6306 VBD denotes were
T3585 6307-6316 VBN denotes sequenced
T3622 6316-6317 . denotes .
T4080 6328-6333 NN denotes Speed
T4081 6334-6342 JJ denotes congenic
T4082 6343-6349 NN denotes strain
T4083 6350-6361 NN denotes development
T4084 6361-6511 sentence denotes Two speed congenic panels were created, the first comprehensively dissected MMU2 while the second isolated QTL on MMU1, 5, 8, 9, 11 and 17 (Table 1).
T4085 6362-6365 CD denotes Two
T4087 6366-6371 NN denotes speed
T4088 6372-6380 JJ denotes congenic
T4086 6381-6387 NNS denotes panels
T4090 6388-6392 VBD denotes were
T4089 6393-6400 VBN denotes created
T4091 6400-6402 , denotes ,
T4092 6402-6405 DT denotes the
T4093 6406-6411 JJ denotes first
T4095 6412-6427 RB denotes comprehensively
T4094 6428-6437 VBN denotes dissected
T4096 6438-6442 NN denotes MMU2
T4097 6443-6448 IN denotes while
T4099 6449-6452 DT denotes the
T4100 6453-6459 JJ denotes second
T4098 6460-6468 VBN denotes isolated
T4101 6469-6472 NN denotes QTL
T4102 6473-6475 IN denotes on
T4103 6476-6479 NN denotes MMU
T4104 6479-6480 CD denotes 1
T4105 6480-6482 , denotes ,
T4106 6482-6483 CD denotes 5
T4107 6483-6485 , denotes ,
T4108 6485-6486 CD denotes 8
T4109 6486-6488 , denotes ,
T4110 6488-6489 CD denotes 9
T4111 6489-6491 , denotes ,
T4112 6491-6493 CD denotes 11
T4113 6494-6497 CC denotes and
T4114 6498-6500 CD denotes 17
T4115 6501-6502 -LRB- denotes (
T4116 6502-6507 NN denotes Table
T4117 6508-6509 CD denotes 1
T4118 6509-6510 -RRB- denotes )
T4119 6510-6511 . denotes .
T4120 6511-6671 sentence denotes The MMU2 panel consisted of eight congenic strains developed by introgressing four overlapping donor regions onto both B6 and HG genetic backgrounds (Table 1).
T4121 6512-6515 DT denotes The
T4123 6516-6520 NN denotes MMU2
T4122 6521-6526 NN denotes panel
T4124 6527-6536 VBD denotes consisted
T4125 6537-6539 IN denotes of
T4126 6540-6545 CD denotes eight
T4128 6546-6554 JJ denotes congenic
T4127 6555-6562 NNS denotes strains
T4129 6563-6572 VBN denotes developed
T4130 6573-6575 IN denotes by
T4131 6576-6589 VBG denotes introgressing
T4132 6590-6594 CD denotes four
T4134 6595-6606 VBG denotes overlapping
T4135 6607-6612 NN denotes donor
T4133 6613-6620 NNS denotes regions
T4136 6621-6625 IN denotes onto
T4137 6626-6630 CC denotes both
T4138 6631-6633 NN denotes B6
T4140 6634-6637 CC denotes and
T4141 6638-6640 NN denotes HG
T4142 6641-6648 JJ denotes genetic
T4139 6649-6660 NNS denotes backgrounds
T4143 6661-6662 -LRB- denotes (
T4144 6662-6667 NN denotes Table
T4145 6668-6669 CD denotes 1
T4146 6669-6670 -RRB- denotes )
T4147 6670-6671 . denotes .
T4148 6671-6790 sentence denotes Single donor regions bred onto an HG background were created to isolate the remaining QTL on MMU1, 5, 8, 9, 11 and 17.
T4149 6672-6678 JJ denotes Single
T4151 6679-6684 NN denotes donor
T4150 6685-6692 NNS denotes regions
T4153 6693-6697 VBN denotes bred
T4154 6698-6702 IN denotes onto
T4155 6703-6705 DT denotes an
T4157 6706-6708 NN denotes HG
T4156 6709-6719 NN denotes background
T4158 6720-6724 VBD denotes were
T4152 6725-6732 VBN denotes created
T4159 6733-6735 TO denotes to
T4160 6736-6743 VB denotes isolate
T4161 6744-6747 DT denotes the
T4163 6748-6757 VBG denotes remaining
T4162 6758-6761 NN denotes QTL
T4164 6762-6764 IN denotes on
T4165 6765-6768 NN denotes MMU
T4166 6768-6769 CD denotes 1
T4167 6769-6771 , denotes ,
T4168 6771-6772 CD denotes 5
T4169 6772-6774 , denotes ,
T4170 6774-6775 CD denotes 8
T4171 6775-6777 , denotes ,
T4172 6777-6778 CD denotes 9
T4173 6778-6780 , denotes ,
T4174 6780-6782 CD denotes 11
T4175 6783-6786 CC denotes and
T4176 6787-6789 CD denotes 17
T4177 6789-6790 . denotes .
T4178 6790-6986 sentence denotes Implementation of a speed congenic approach using marker-assisted breeding with 79 genome-wide microsatellite markers accelerated production of all strains [5,6] (Additional File 1 and Figure 1).
T4179 6791-6805 NN denotes Implementation
T4181 6806-6808 IN denotes of
T4182 6809-6810 DT denotes a
T4184 6811-6816 NN denotes speed
T4185 6817-6825 JJ denotes congenic
T4183 6826-6834 NN denotes approach
T4186 6835-6840 VBG denotes using
T4187 6841-6847 NN denotes marker
T4189 6847-6848 HYPH denotes -
T4188 6848-6856 VBN denotes assisted
T4190 6857-6865 NN denotes breeding
T4191 6866-6870 IN denotes with
T4192 6871-6873 CD denotes 79
T4194 6874-6880 NN denotes genome
T4196 6880-6881 HYPH denotes -
T4195 6881-6885 JJ denotes wide
T4197 6886-6900 NN denotes microsatellite
T4193 6901-6908 NNS denotes markers
T4180 6909-6920 VBD denotes accelerated
T4198 6921-6931 NN denotes production
T4199 6932-6934 IN denotes of
T4200 6935-6938 DT denotes all
T4201 6939-6946 NNS denotes strains
T4202 6947-6948 -LRB- denotes [
T4204 6948-6949 CD denotes 5
T4205 6949-6950 , denotes ,
T4203 6950-6951 CD denotes 6
T4206 6951-6952 -RRB- denotes ]
T4207 6953-6954 -LRB- denotes (
T4209 6954-6964 JJ denotes Additional
T4208 6965-6969 NN denotes File
T4210 6970-6971 CD denotes 1
T4211 6972-6975 CC denotes and
T4212 6976-6982 NN denotes Figure
T4213 6983-6984 CD denotes 1
T4214 6984-6985 -RRB- denotes )
T4215 6985-6986 . denotes .
T4216 6986-7073 sentence denotes Strain abbreviations and genomic region isolated by each strain are listed in Table 1.
T4217 6987-6993 NN denotes Strain
T4218 6994-7007 NNS denotes abbreviations
T4220 7008-7011 CC denotes and
T4221 7012-7019 JJ denotes genomic
T4222 7020-7026 NN denotes region
T4223 7027-7035 VBN denotes isolated
T4224 7036-7038 IN denotes by
T4225 7039-7043 DT denotes each
T4226 7044-7050 NN denotes strain
T4227 7051-7054 VBP denotes are
T4219 7055-7061 VBN denotes listed
T4228 7062-7064 IN denotes in
T4229 7065-7070 NN denotes Table
T4230 7071-7072 CD denotes 1
T4231 7072-7073 . denotes .
T4232 7073-7317 sentence denotes In addition to both congenic panels, two control strains homozygous B6 (B6.CASTC; B6C) or HG (HG.CASTC; HGC) for all genome-wide markers genotyped were developed from the same cross (see Methods) and served as the basis for strain comparisons.
T4233 7074-7076 IN denotes In
T4235 7077-7085 NN denotes addition
T4236 7086-7088 IN denotes to
T4237 7089-7093 CC denotes both
T4239 7094-7102 JJ denotes congenic
T4238 7103-7109 NNS denotes panels
T4240 7109-7111 , denotes ,
T4241 7111-7114 CD denotes two
T4243 7115-7122 NN denotes control
T4242 7123-7130 NNS denotes strains
T4244 7131-7141 JJ denotes homozygous
T4245 7142-7144 NN denotes B6
T4246 7145-7146 -LRB- denotes (
T4247 7146-7154 NN denotes B6.CASTC
T4249 7154-7155 : denotes ;
T4248 7156-7159 NN denotes B6C
T4250 7159-7160 -RRB- denotes )
T4251 7161-7163 CC denotes or
T4252 7164-7166 NN denotes HG
T4253 7167-7168 -LRB- denotes (
T4254 7168-7176 NN denotes HG.CASTC
T4256 7176-7177 : denotes ;
T4255 7178-7181 NN denotes HGC
T4257 7181-7182 -RRB- denotes )
T4258 7183-7186 IN denotes for
T4259 7187-7190 DT denotes all
T4261 7191-7197 NN denotes genome
T4263 7197-7198 HYPH denotes -
T4262 7198-7202 JJ denotes wide
T4260 7203-7210 NNS denotes markers
T4264 7211-7220 VBN denotes genotyped
T4265 7221-7225 VBD denotes were
T4234 7226-7235 VBN denotes developed
T4266 7236-7240 IN denotes from
T4267 7241-7244 DT denotes the
T4269 7245-7249 JJ denotes same
T4268 7250-7255 NN denotes cross
T4270 7256-7257 -LRB- denotes (
T4271 7257-7260 VB denotes see
T4272 7261-7268 NNS denotes Methods
T4273 7268-7269 -RRB- denotes )
T4274 7270-7273 CC denotes and
T4275 7274-7280 VBD denotes served
T4276 7281-7283 IN denotes as
T4277 7284-7287 DT denotes the
T4278 7288-7293 NN denotes basis
T4279 7294-7297 IN denotes for
T4280 7298-7304 NN denotes strain
T4281 7305-7316 NNS denotes comparisons
T4282 7316-7317 . denotes .
T4283 7317-7419 sentence denotes After stabilizing each congenic, 12 of 14 were phenotypically characterized for growth and adiposity.
T4284 7318-7323 IN denotes After
T4286 7324-7335 VBG denotes stabilizing
T4287 7336-7340 DT denotes each
T4288 7341-7349 JJ denotes congenic
T4289 7349-7351 , denotes ,
T4290 7351-7353 CD denotes 12
T4292 7354-7356 IN denotes of
T4291 7357-7359 CD denotes 14
T4293 7360-7364 VBD denotes were
T4294 7365-7379 RB denotes phenotypically
T4285 7380-7393 VBN denotes characterized
T4295 7394-7397 IN denotes for
T4296 7398-7404 NN denotes growth
T4297 7405-7408 CC denotes and
T4298 7409-7418 NN denotes adiposity
T4299 7418-7419 . denotes .
T4300 7419-7497 sentence denotes The HG2D and HG5 strains were not characterized due to reproductive problems.
T4301 7420-7423 DT denotes The
T4303 7424-7428 NN denotes HG2D
T4304 7429-7432 CC denotes and
T4305 7433-7436 NN denotes HG5
T4302 7437-7444 NNS denotes strains
T4307 7445-7449 VBD denotes were
T4308 7450-7453 RB denotes not
T4306 7454-7467 VBN denotes characterized
T4309 7468-7471 IN denotes due
T4310 7472-7474 IN denotes to
T4311 7475-7487 JJ denotes reproductive
T4312 7488-7496 NNS denotes problems
T4313 7496-7497 . denotes .
T4314 7497-7630 sentence denotes The recombinant end points for all strains were refined using microsatellite markers flanking each donor region (Additional File 2).
T4315 7498-7501 DT denotes The
T4317 7502-7513 JJ denotes recombinant
T4318 7514-7517 NN denotes end
T4316 7518-7524 NNS denotes points
T4320 7525-7528 IN denotes for
T4321 7529-7532 DT denotes all
T4322 7533-7540 NNS denotes strains
T4323 7541-7545 VBD denotes were
T4319 7546-7553 VBN denotes refined
T4324 7554-7559 VBG denotes using
T4325 7560-7574 NN denotes microsatellite
T4326 7575-7582 NNS denotes markers
T4327 7583-7591 VBG denotes flanking
T4328 7592-7596 DT denotes each
T4330 7597-7602 NN denotes donor
T4329 7603-7609 NN denotes region
T4331 7610-7611 -LRB- denotes (
T4333 7611-7621 JJ denotes Additional
T4332 7622-7626 NN denotes File
T4334 7627-7628 CD denotes 2
T4335 7628-7629 -RRB- denotes )
T4336 7629-7630 . denotes .
T6950 7632-7636 NN denotes MMU2
T6952 7637-7642 NN denotes speed
T6953 7643-7651 JJ denotes congenic
T6951 7652-7658 NN denotes strain
T6954 7659-7675 NN denotes characterization
T6955 7675-7825 sentence denotes Due to the overlapping nature of the MMU2 congenics, five distinct chromosomal regions (Regions I–V) were queried for the presence of QTL (Figure 2).
T6956 7676-7679 IN denotes Due
T6958 7680-7682 IN denotes to
T6959 7683-7686 DT denotes the
T6961 7687-7698 VBG denotes overlapping
T6960 7699-7705 NN denotes nature
T6962 7706-7708 IN denotes of
T6963 7709-7712 DT denotes the
T6965 7713-7717 NN denotes MMU2
T6964 7718-7727 NNS denotes congenics
T6966 7727-7729 , denotes ,
T6967 7729-7733 CD denotes five
T6969 7734-7742 JJ denotes distinct
T6970 7743-7754 JJ denotes chromosomal
T6968 7755-7762 NNS denotes regions
T6971 7763-7764 -LRB- denotes (
T6972 7764-7771 NNS denotes Regions
T6973 7772-7773 CD denotes I
T6974 7773-7774 SYM denotes –
T6975 7774-7775 CD denotes V
T6976 7775-7776 -RRB- denotes )
T6977 7777-7781 VBD denotes were
T6957 7782-7789 VBN denotes queried
T6978 7790-7793 IN denotes for
T6979 7794-7797 DT denotes the
T6980 7798-7806 NN denotes presence
T6981 7807-7809 IN denotes of
T6982 7810-7813 NN denotes QTL
T6983 7814-7815 -LRB- denotes (
T6984 7815-7821 NN denotes Figure
T6985 7822-7823 CD denotes 2
T6986 7823-7824 -RRB- denotes )
T6987 7824-7825 . denotes .
T6988 7825-7948 sentence denotes As a separate analysis we also tested for interactions between each donor region and the two distinct genetic backgrounds.
T6989 7826-7828 IN denotes As
T6991 7829-7830 DT denotes a
T6993 7831-7839 JJ denotes separate
T6992 7840-7848 NN denotes analysis
T6994 7849-7851 PRP denotes we
T6995 7852-7856 RB denotes also
T6990 7857-7863 VBN denotes tested
T6996 7864-7867 IN denotes for
T6997 7868-7880 NNS denotes interactions
T6998 7881-7888 IN denotes between
T6999 7889-7893 DT denotes each
T7001 7894-7899 NN denotes donor
T7000 7900-7906 NN denotes region
T7002 7907-7910 CC denotes and
T7003 7911-7914 DT denotes the
T7005 7915-7918 CD denotes two
T7006 7919-7927 JJ denotes distinct
T7007 7928-7935 JJ denotes genetic
T7004 7936-7947 NNS denotes backgrounds
T7008 7947-7948 . denotes .
T7009 7948-8098 sentence denotes The following sections describe the phenotypes for each B6.CAST and HG.CAST speed congenic strain as well as the results of the interaction analysis.
T7010 7949-7952 DT denotes The
T7012 7953-7962 JJ denotes following
T7011 7963-7971 NNS denotes sections
T7013 7972-7980 VBP denotes describe
T7014 7981-7984 DT denotes the
T7015 7985-7995 NNS denotes phenotypes
T7016 7996-7999 IN denotes for
T7017 8000-8004 DT denotes each
T7019 8005-8012 NN denotes B6.CAST
T7020 8013-8016 CC denotes and
T7021 8017-8024 NN denotes HG.CAST
T7022 8025-8030 NN denotes speed
T7023 8031-8039 JJ denotes congenic
T7018 8040-8046 NN denotes strain
T7024 8047-8049 RB denotes as
T7026 8050-8054 RB denotes well
T7025 8055-8057 IN denotes as
T7027 8058-8061 DT denotes the
T7028 8062-8069 NNS denotes results
T7029 8070-8072 IN denotes of
T7030 8073-8076 DT denotes the
T7032 8077-8088 NN denotes interaction
T7031 8089-8097 NN denotes analysis
T7033 8097-8098 . denotes .
T7034 8098-8135 sentence denotes B6.CAST MMU2 speed congenic strains
T7035 8100-8107 NN denotes B6.CAST
T7036 8108-8112 NN denotes MMU2
T7038 8113-8118 NN denotes speed
T7039 8119-8127 JJ denotes congenic
T7037 8128-8135 NNS denotes strains
T7040 8135-8256 sentence denotes The B62D strain exhibited the largest (P < 0.0001) decreases in body weight of any B6.CAST congenic (Additional File 3).
T7041 8136-8139 DT denotes The
T7043 8140-8144 NN denotes B62D
T7042 8145-8151 NN denotes strain
T7044 8152-8161 VBD denotes exhibited
T7045 8162-8165 DT denotes the
T7047 8166-8173 JJS denotes largest
T7048 8174-8175 -LRB- denotes (
T7050 8175-8176 NN denotes P
T7051 8177-8178 SYM denotes <
T7049 8179-8185 CD denotes 0.0001
T7052 8185-8186 -RRB- denotes )
T7046 8187-8196 NNS denotes decreases
T7053 8197-8199 IN denotes in
T7054 8200-8204 NN denotes body
T7055 8205-8211 NN denotes weight
T7056 8212-8214 IN denotes of
T7057 8215-8218 DT denotes any
T7058 8219-8226 NN denotes B6.CAST
T7059 8227-8235 JJ denotes congenic
T7060 8236-8237 -LRB- denotes (
T7062 8237-8247 JJ denotes Additional
T7061 8248-8252 NN denotes File
T7063 8253-8254 CD denotes 3
T7064 8254-8255 -RRB- denotes )
T7065 8255-8256 . denotes .
T7066 8256-8387 sentence denotes Both sexes had reductions in weight at 2 (2WK), 3 (3WK), 6 (6WK) and 9 (9WK) weeks of age compared to control B6C mice (Figure 3).
T7067 8257-8261 DT denotes Both
T7068 8262-8267 NNS denotes sexes
T7069 8268-8271 VBD denotes had
T7070 8272-8282 NNS denotes reductions
T7071 8283-8285 IN denotes in
T7072 8286-8292 NN denotes weight
T7073 8293-8295 IN denotes at
T7074 8296-8297 CD denotes 2
T7076 8298-8299 -LRB- denotes (
T7077 8299-8302 NN denotes 2WK
T7078 8302-8303 -RRB- denotes )
T7079 8303-8305 , denotes ,
T7080 8305-8306 CD denotes 3
T7081 8307-8308 -LRB- denotes (
T7082 8308-8311 NN denotes 3WK
T7083 8311-8312 -RRB- denotes )
T7084 8312-8314 , denotes ,
T7085 8314-8315 CD denotes 6
T7086 8316-8317 -LRB- denotes (
T7087 8317-8320 NN denotes 6WK
T7088 8320-8321 -RRB- denotes )
T7089 8322-8325 CC denotes and
T7090 8326-8327 CD denotes 9
T7091 8328-8329 -LRB- denotes (
T7092 8329-8332 NN denotes 9WK
T7093 8332-8333 -RRB- denotes )
T7075 8334-8339 NNS denotes weeks
T7094 8340-8342 IN denotes of
T7095 8343-8346 NN denotes age
T7096 8347-8355 VBN denotes compared
T7097 8356-8358 IN denotes to
T7098 8359-8366 NN denotes control
T7100 8367-8370 NN denotes B6C
T7099 8371-8375 NNS denotes mice
T7101 8376-8377 -LRB- denotes (
T7102 8377-8383 NN denotes Figure
T7103 8384-8385 CD denotes 3
T7104 8385-8386 -RRB- denotes )
T7105 8386-8387 . denotes .
T7106 8387-8569 sentence denotes Despite large decreases in body weight, no differences in growth rates (G26, weight gain from 2 to 6 weeks and G29, weight gain from 2 to 9 weeks) were observed (Additional File 3).
T7107 8388-8395 IN denotes Despite
T7109 8396-8401 JJ denotes large
T7110 8402-8411 NNS denotes decreases
T7111 8412-8414 IN denotes in
T7112 8415-8419 NN denotes body
T7113 8420-8426 NN denotes weight
T7114 8426-8428 , denotes ,
T7115 8428-8430 DT denotes no
T7116 8431-8442 NNS denotes differences
T7117 8443-8445 IN denotes in
T7118 8446-8452 NN denotes growth
T7119 8453-8458 NNS denotes rates
T7120 8459-8460 -LRB- denotes (
T7122 8460-8463 NN denotes G26
T7123 8463-8465 , denotes ,
T7124 8465-8471 NN denotes weight
T7121 8472-8476 NN denotes gain
T7125 8477-8481 IN denotes from
T7126 8482-8483 CD denotes 2
T7128 8484-8486 IN denotes to
T7127 8487-8488 CD denotes 6
T7129 8489-8494 NNS denotes weeks
T7130 8495-8498 CC denotes and
T7131 8499-8502 NN denotes G29
T7133 8502-8504 , denotes ,
T7134 8504-8510 NN denotes weight
T7132 8511-8515 NN denotes gain
T7135 8516-8520 IN denotes from
T7136 8521-8522 CD denotes 2
T7138 8523-8525 IN denotes to
T7137 8526-8527 CD denotes 9
T7139 8528-8533 NNS denotes weeks
T7140 8533-8534 -RRB- denotes )
T7141 8535-8539 VBD denotes were
T7108 8540-8548 VBN denotes observed
T7142 8549-8550 -LRB- denotes (
T7144 8550-8560 JJ denotes Additional
T7143 8561-8565 NN denotes File
T7145 8566-8567 CD denotes 3
T7146 8567-8568 -RRB- denotes )
T7147 8568-8569 . denotes .
T7148 8569-8741 sentence denotes Therefore, the B62D unique region (Region V) harbors either an early-growth QTL or maternal genotype effect which produces a distinct decrease in body weight prior to 2WK.
T7149 8570-8579 RB denotes Therefore
T7151 8579-8581 , denotes ,
T7152 8581-8584 DT denotes the
T7154 8585-8589 NN denotes B62D
T7155 8590-8596 JJ denotes unique
T7153 8597-8603 NN denotes region
T7156 8604-8605 -LRB- denotes (
T7157 8605-8611 NN denotes Region
T7158 8612-8613 CD denotes V
T7159 8613-8614 -RRB- denotes )
T7150 8615-8622 VBZ denotes harbors
T7160 8623-8629 CC denotes either
T7162 8630-8632 DT denotes an
T7163 8633-8638 JJ denotes early
T7165 8638-8639 HYPH denotes -
T7164 8639-8645 NN denotes growth
T7161 8646-8649 NN denotes QTL
T7166 8650-8652 CC denotes or
T7167 8653-8661 JJ denotes maternal
T7169 8662-8670 NN denotes genotype
T7168 8671-8677 NN denotes effect
T7170 8678-8683 WDT denotes which
T7171 8684-8692 VBZ denotes produces
T7172 8693-8694 DT denotes a
T7174 8695-8703 JJ denotes distinct
T7173 8704-8712 NN denotes decrease
T7175 8713-8715 IN denotes in
T7176 8716-8720 NN denotes body
T7177 8721-8727 NN denotes weight
T7178 8728-8733 JJ denotes prior
T7179 8734-8736 IN denotes to
T7180 8737-8740 NN denotes 2WK
T7181 8740-8741 . denotes .
T7182 8741-8830 sentence denotes These effects are evident in the growth curves for both sexes of each strain (Figure 3).
T7183 8742-8747 DT denotes These
T7184 8748-8755 NNS denotes effects
T7185 8756-8759 VBP denotes are
T7186 8760-8767 JJ denotes evident
T7187 8768-8770 IN denotes in
T7188 8771-8774 DT denotes the
T7190 8775-8781 NN denotes growth
T7189 8782-8788 NNS denotes curves
T7191 8789-8792 IN denotes for
T7192 8793-8797 DT denotes both
T7193 8798-8803 NNS denotes sexes
T7194 8804-8806 IN denotes of
T7195 8807-8811 DT denotes each
T7196 8812-8818 NN denotes strain
T7197 8819-8820 -LRB- denotes (
T7198 8820-8826 NN denotes Figure
T7199 8827-8828 CD denotes 3
T7200 8828-8829 -RRB- denotes )
T7201 8829-8830 . denotes .
T7202 8830-8957 sentence denotes Additionally, B62D mice displayed significantly shorter tail lengths despite no difference in naso-anal length (NA) (Table 2).
T7203 8831-8843 RB denotes Additionally
T7205 8843-8845 , denotes ,
T7206 8845-8849 NN denotes B62D
T7207 8850-8854 NNS denotes mice
T7204 8855-8864 VBD denotes displayed
T7208 8865-8878 RB denotes significantly
T7209 8879-8886 JJR denotes shorter
T7211 8887-8891 NN denotes tail
T7210 8892-8899 NNS denotes lengths
T7212 8900-8907 IN denotes despite
T7213 8908-8910 DT denotes no
T7214 8911-8921 NN denotes difference
T7215 8922-8924 IN denotes in
T7216 8925-8934 JJ denotes naso-anal
T7217 8935-8941 NN denotes length
T7218 8942-8943 -LRB- denotes (
T7219 8943-8945 NN denotes NA
T7220 8945-8946 -RRB- denotes )
T7221 8947-8948 -LRB- denotes (
T7222 8948-8953 NN denotes Table
T7223 8954-8955 CD denotes 2
T7224 8955-8956 -RRB- denotes )
T7225 8956-8957 . denotes .
T7226 8957-9207 sentence denotes In contrast, B62M mice displayed small decreases in body weights and growth (male 9WK was significant, female 6WK and 9WK were suggestive at P < 0.05) and significant decreases in NA (male P = 0.0152) and tail length (Additional File 3 and Table 2).
T7227 8958-8960 IN denotes In
T7229 8961-8969 NN denotes contrast
T7230 8969-8971 , denotes ,
T7231 8971-8975 NN denotes B62M
T7232 8976-8980 NNS denotes mice
T7228 8981-8990 VBD denotes displayed
T7233 8991-8996 JJ denotes small
T7234 8997-9006 NNS denotes decreases
T7235 9007-9009 IN denotes in
T7236 9010-9014 NN denotes body
T7237 9015-9022 NNS denotes weights
T7238 9023-9026 CC denotes and
T7239 9027-9033 NN denotes growth
T7240 9034-9035 -LRB- denotes (
T7242 9035-9039 JJ denotes male
T7243 9040-9043 NN denotes 9WK
T7244 9044-9047 VBD denotes was
T7245 9048-9059 JJ denotes significant
T7246 9059-9061 , denotes ,
T7247 9061-9067 JJ denotes female
T7248 9068-9071 NN denotes 6WK
T7249 9072-9075 CC denotes and
T7250 9076-9079 NN denotes 9WK
T7241 9080-9084 VBD denotes were
T7251 9085-9095 JJ denotes suggestive
T7252 9096-9098 IN denotes at
T7253 9099-9100 NN denotes P
T7255 9101-9102 SYM denotes <
T7254 9103-9107 CD denotes 0.05
T7256 9107-9108 -RRB- denotes )
T7257 9109-9112 CC denotes and
T7258 9113-9124 JJ denotes significant
T7259 9125-9134 NNS denotes decreases
T7260 9135-9137 IN denotes in
T7261 9138-9140 NN denotes NA
T7263 9141-9142 -LRB- denotes (
T7265 9142-9146 JJ denotes male
T7266 9147-9148 NN denotes P
T7267 9149-9150 SYM denotes =
T7264 9151-9157 CD denotes 0.0152
T7268 9157-9158 -RRB- denotes )
T7269 9159-9162 CC denotes and
T7270 9163-9167 NN denotes tail
T7262 9168-9174 NN denotes length
T7271 9175-9176 -LRB- denotes (
T7273 9176-9186 JJ denotes Additional
T7272 9187-9191 NN denotes File
T7274 9192-9193 CD denotes 3
T7275 9194-9197 CC denotes and
T7276 9198-9203 NN denotes Table
T7277 9204-9205 CD denotes 2
T7278 9205-9206 -RRB- denotes )
T7279 9206-9207 . denotes .
T7280 9207-9378 sentence denotes The decrease in NA in B62M mice is surprising since the 2M donor region is entirely nested within the 2D donor region and B62D mice showed no difference in NA (Figure 2).
T7281 9208-9211 DT denotes The
T7282 9212-9220 NN denotes decrease
T7284 9221-9223 IN denotes in
T7285 9224-9226 NN denotes NA
T7286 9227-9229 IN denotes in
T7287 9230-9234 NN denotes B62M
T7288 9235-9239 NNS denotes mice
T7283 9240-9242 VBZ denotes is
T7289 9243-9253 JJ denotes surprising
T7290 9254-9259 IN denotes since
T7292 9260-9263 DT denotes the
T7294 9264-9266 NN denotes 2M
T7295 9267-9272 NN denotes donor
T7293 9273-9279 NN denotes region
T7296 9280-9282 VBZ denotes is
T7297 9283-9291 RB denotes entirely
T7291 9292-9298 VBN denotes nested
T7298 9299-9305 IN denotes within
T7299 9306-9309 DT denotes the
T7301 9310-9312 NN denotes 2D
T7302 9313-9318 NN denotes donor
T7300 9319-9325 NN denotes region
T7303 9326-9329 CC denotes and
T7304 9330-9334 NN denotes B62D
T7305 9335-9339 NNS denotes mice
T7306 9340-9346 VBD denotes showed
T7307 9347-9349 DT denotes no
T7308 9350-9360 NN denotes difference
T7309 9361-9363 IN denotes in
T7310 9364-9366 NN denotes NA
T7311 9367-9368 -LRB- denotes (
T7312 9368-9374 NN denotes Figure
T7313 9375-9376 CD denotes 2
T7314 9376-9377 -RRB- denotes )
T7315 9377-9378 . denotes .
T7316 9378-9451 sentence denotes These data indicate the presence of three QTL with the 2D unique region.
T7317 9379-9384 DT denotes These
T7318 9385-9389 NNS denotes data
T7319 9390-9398 VBP denotes indicate
T7320 9399-9402 DT denotes the
T7321 9403-9411 NN denotes presence
T7322 9412-9414 IN denotes of
T7323 9415-9420 CD denotes three
T7324 9421-9424 NN denotes QTL
T7325 9425-9429 IN denotes with
T7326 9430-9433 DT denotes the
T7328 9434-9436 NN denotes 2D
T7329 9437-9443 JJ denotes unique
T7327 9444-9450 NN denotes region
T7330 9450-9451 . denotes .
T7331 9451-9572 sentence denotes Two of which are disjoined by the B62M and B62D strains and additively decrease body weight and tail length, but not NA.
T7332 9452-9455 CD denotes Two
T7334 9456-9458 IN denotes of
T7335 9459-9464 WDT denotes which
T7336 9465-9468 VBP denotes are
T7333 9469-9478 VBN denotes disjoined
T7337 9479-9481 IN denotes by
T7338 9482-9485 DT denotes the
T7340 9486-9490 NN denotes B62M
T7341 9491-9494 CC denotes and
T7342 9495-9499 NN denotes B62D
T7339 9500-9507 NNS denotes strains
T7343 9508-9511 CC denotes and
T7344 9512-9522 RB denotes additively
T7345 9523-9531 VBP denotes decrease
T7346 9532-9536 NN denotes body
T7347 9537-9543 NN denotes weight
T7348 9544-9547 CC denotes and
T7349 9548-9552 NN denotes tail
T7350 9553-9559 NN denotes length
T7351 9559-9561 , denotes ,
T7352 9561-9564 CC denotes but
T7353 9565-9568 RB denotes not
T7354 9569-9571 NN denotes NA
T7355 9571-9572 . denotes .
T7356 9572-9715 sentence denotes The third QTL, located within the B62D unique region (Region V), increases NA canceling the effects of the B62M QTL (Region IV) decreasing NA.
T7357 9573-9576 DT denotes The
T7359 9577-9582 JJ denotes third
T7358 9583-9586 NN denotes QTL
T7361 9586-9588 , denotes ,
T7362 9588-9595 VBN denotes located
T7363 9596-9602 IN denotes within
T7364 9603-9606 DT denotes the
T7366 9607-9611 NN denotes B62D
T7367 9612-9618 JJ denotes unique
T7365 9619-9625 NN denotes region
T7368 9626-9627 -LRB- denotes (
T7369 9627-9633 NN denotes Region
T7370 9634-9635 CD denotes V
T7371 9635-9636 -RRB- denotes )
T7372 9636-9638 , denotes ,
T7360 9638-9647 VBZ denotes increases
T7373 9648-9650 NN denotes NA
T7374 9651-9660 VBG denotes canceling
T7375 9661-9664 DT denotes the
T7376 9665-9672 NNS denotes effects
T7377 9673-9675 IN denotes of
T7378 9676-9679 DT denotes the
T7380 9680-9684 NN denotes B62M
T7379 9685-9688 NN denotes QTL
T7382 9689-9690 -LRB- denotes (
T7383 9690-9696 NN denotes Region
T7384 9697-9699 CD denotes IV
T7385 9699-9700 -RRB- denotes )
T7381 9701-9711 VBG denotes decreasing
T7386 9712-9714 NN denotes NA
T7387 9714-9715 . denotes .
T7388 9715-9853 sentence denotes B62PM females had decreases in all growth-related traits except 2WK and 3WK, while no differences were seen in males (Additional File 3).
T7389 9716-9721 NN denotes B62PM
T7390 9722-9729 NNS denotes females
T7391 9730-9733 VBD denotes had
T7392 9734-9743 NNS denotes decreases
T7393 9744-9746 IN denotes in
T7394 9747-9750 DT denotes all
T7396 9751-9757 NN denotes growth
T7398 9757-9758 HYPH denotes -
T7397 9758-9765 VBN denotes related
T7395 9766-9772 NNS denotes traits
T7399 9773-9779 IN denotes except
T7400 9780-9783 NN denotes 2WK
T7401 9784-9787 CC denotes and
T7402 9788-9791 NN denotes 3WK
T7403 9791-9793 , denotes ,
T7404 9793-9798 IN denotes while
T7406 9799-9801 DT denotes no
T7407 9802-9813 NNS denotes differences
T7408 9814-9818 VBD denotes were
T7405 9819-9823 VBN denotes seen
T7409 9824-9826 IN denotes in
T7410 9827-9832 NNS denotes males
T7411 9833-9834 -LRB- denotes (
T7413 9834-9844 JJ denotes Additional
T7412 9845-9849 NN denotes File
T7414 9850-9851 CD denotes 3
T7415 9851-9852 -RRB- denotes )
T7416 9852-9853 . denotes .
T7417 9853-10043 sentence denotes Similarly, only B62P females and not males showed significant decreases in 9WK, G26 and G29 (Additional File 3), indicating these two strains share a female specific growth QTL (Region II).
T7418 9854-9863 RB denotes Similarly
T7420 9863-9865 , denotes ,
T7421 9865-9869 RB denotes only
T7423 9870-9874 NN denotes B62P
T7422 9875-9882 NNS denotes females
T7424 9883-9886 CC denotes and
T7425 9887-9890 RB denotes not
T7426 9891-9896 NNS denotes males
T7419 9897-9903 VBD denotes showed
T7427 9904-9915 JJ denotes significant
T7428 9916-9925 NNS denotes decreases
T7429 9926-9928 IN denotes in
T7430 9929-9932 NN denotes 9WK
T7431 9932-9934 , denotes ,
T7432 9934-9937 NN denotes G26
T7433 9938-9941 CC denotes and
T7434 9942-9945 NN denotes G29
T7435 9946-9947 -LRB- denotes (
T7437 9947-9957 JJ denotes Additional
T7436 9958-9962 NN denotes File
T7438 9963-9964 CD denotes 3
T7439 9964-9965 -RRB- denotes )
T7440 9965-9967 , denotes ,
T7441 9967-9977 VBG denotes indicating
T7442 9978-9983 DT denotes these
T7444 9984-9987 CD denotes two
T7443 9988-9995 NNS denotes strains
T7445 9996-10001 VBP denotes share
T7446 10002-10003 DT denotes a
T7448 10004-10010 JJ denotes female
T7449 10011-10019 JJ denotes specific
T7450 10020-10026 NN denotes growth
T7447 10027-10030 NN denotes QTL
T7451 10031-10032 -LRB- denotes (
T7452 10032-10038 NN denotes Region
T7453 10039-10041 CD denotes II
T7454 10041-10042 -RRB- denotes )
T7455 10042-10043 . denotes .
T7456 10043-10180 sentence denotes In the original genome scan body fat percentage as determined by chemical compositional analysis was not linked to markers on MMU2 [24].
T7457 10044-10046 IN denotes In
T7459 10047-10050 DT denotes the
T7461 10051-10059 JJ denotes original
T7462 10060-10066 NN denotes genome
T7460 10067-10071 NN denotes scan
T7463 10072-10076 NN denotes body
T7464 10077-10080 NN denotes fat
T7465 10081-10091 NN denotes percentage
T7466 10092-10094 IN denotes as
T7467 10095-10105 VBN denotes determined
T7468 10106-10108 IN denotes by
T7469 10109-10117 JJ denotes chemical
T7471 10118-10131 JJ denotes compositional
T7470 10132-10140 NN denotes analysis
T7472 10141-10144 VBD denotes was
T7473 10145-10148 RB denotes not
T7458 10149-10155 VBN denotes linked
T7474 10156-10158 IN denotes to
T7475 10159-10166 NNS denotes markers
T7476 10167-10169 IN denotes on
T7477 10170-10174 NN denotes MMU2
T7478 10175-10176 -LRB- denotes [
T7479 10176-10178 CD denotes 24
T7480 10178-10179 -RRB- denotes ]
T7481 10179-10180 . denotes .
T7482 10180-10393 sentence denotes However, since numerous obesity QTL have been found on MMU2 [2], some of which were discovered in B6 by CAST crosses [9,25], we chose to measure dissected fat pad weights as a more sensitive measure of adiposity.
T7483 10181-10188 RB denotes However
T7485 10188-10190 , denotes ,
T7486 10190-10195 IN denotes since
T7488 10196-10204 JJ denotes numerous
T7490 10205-10212 NN denotes obesity
T7489 10213-10216 NN denotes QTL
T7491 10217-10221 VBP denotes have
T7492 10222-10226 VBN denotes been
T7487 10227-10232 VBN denotes found
T7493 10233-10235 IN denotes on
T7494 10236-10240 NN denotes MMU2
T7495 10241-10242 -LRB- denotes [
T7496 10242-10243 CD denotes 2
T7497 10243-10244 -RRB- denotes ]
T7498 10244-10246 , denotes ,
T7499 10246-10250 DT denotes some
T7501 10251-10253 IN denotes of
T7502 10254-10259 WDT denotes which
T7503 10260-10264 VBD denotes were
T7500 10265-10275 VBN denotes discovered
T7504 10276-10278 IN denotes in
T7505 10279-10281 NN denotes B6
T7506 10282-10284 IN denotes by
T7507 10285-10289 NN denotes CAST
T7508 10290-10297 NNS denotes crosses
T7509 10298-10299 -LRB- denotes [
T7511 10299-10300 CD denotes 9
T7512 10300-10301 , denotes ,
T7510 10301-10303 CD denotes 25
T7513 10303-10304 -RRB- denotes ]
T7514 10304-10306 , denotes ,
T7515 10306-10308 PRP denotes we
T7484 10309-10314 VBD denotes chose
T7516 10315-10317 TO denotes to
T7517 10318-10325 VB denotes measure
T7518 10326-10335 VBN denotes dissected
T7520 10336-10339 NN denotes fat
T7521 10340-10343 NN denotes pad
T7519 10344-10351 NNS denotes weights
T7522 10352-10354 IN denotes as
T7523 10355-10356 DT denotes a
T7525 10357-10361 RBR denotes more
T7526 10362-10371 JJ denotes sensitive
T7524 10372-10379 NN denotes measure
T7527 10380-10382 IN denotes of
T7528 10383-10392 NN denotes adiposity
T7529 10392-10393 . denotes .
T7530 10393-10691 sentence denotes Table 2 lists the weights of gonadal (GFP), femoral (FFP), mesenteric (MFP) and retroperitoneal (RFP) fat pads, along with total fat pad weight (sum of the four fat pads), adiposity index (AI = TF/weight at sacrifice (WSAC)) and body mass index (BMI = WSAC/NA2 *100) for each MMU2 congenic strain.
T7531 10394-10399 NN denotes Table
T7533 10400-10401 CD denotes 2
T7532 10402-10407 VBZ denotes lists
T7534 10408-10411 DT denotes the
T7535 10412-10419 NNS denotes weights
T7536 10420-10422 IN denotes of
T7537 10423-10430 JJ denotes gonadal
T7539 10431-10432 -LRB- denotes (
T7540 10432-10435 NN denotes GFP
T7541 10435-10436 -RRB- denotes )
T7542 10436-10438 , denotes ,
T7543 10438-10445 JJ denotes femoral
T7544 10446-10447 -LRB- denotes (
T7545 10447-10450 NN denotes FFP
T7546 10450-10451 -RRB- denotes )
T7547 10451-10453 , denotes ,
T7548 10453-10463 JJ denotes mesenteric
T7549 10464-10465 -LRB- denotes (
T7550 10465-10468 NN denotes MFP
T7551 10468-10469 -RRB- denotes )
T7552 10470-10473 CC denotes and
T7553 10474-10489 JJ denotes retroperitoneal
T7554 10490-10491 -LRB- denotes (
T7555 10491-10494 NN denotes RFP
T7556 10494-10495 -RRB- denotes )
T7557 10496-10499 NN denotes fat
T7538 10500-10504 NNS denotes pads
T7558 10504-10506 , denotes ,
T7559 10506-10511 IN denotes along
T7560 10512-10516 IN denotes with
T7561 10517-10522 JJ denotes total
T7563 10523-10526 NN denotes fat
T7564 10527-10530 NN denotes pad
T7562 10531-10537 NN denotes weight
T7565 10538-10539 -LRB- denotes (
T7566 10539-10542 NN denotes sum
T7567 10543-10545 IN denotes of
T7568 10546-10549 DT denotes the
T7570 10550-10554 CD denotes four
T7571 10555-10558 NN denotes fat
T7569 10559-10563 NNS denotes pads
T7572 10563-10564 -RRB- denotes )
T7573 10564-10566 , denotes ,
T7574 10566-10575 NN denotes adiposity
T7575 10576-10581 NN denotes index
T7576 10582-10583 -LRB- denotes (
T7578 10583-10585 NN denotes AI
T7580 10586-10587 SYM denotes =
T7579 10588-10590 NN denotes TF
T7581 10590-10591 SYM denotes /
T7582 10591-10597 NN denotes weight
T7583 10598-10600 IN denotes at
T7584 10601-10610 NN denotes sacrifice
T7585 10611-10612 -LRB- denotes (
T7577 10612-10616 NN denotes WSAC
T7586 10616-10617 -RRB- denotes )
T7587 10617-10618 -RRB- denotes )
T7588 10619-10622 CC denotes and
T7589 10623-10627 NN denotes body
T7591 10628-10632 NN denotes mass
T7590 10633-10638 NN denotes index
T7592 10639-10640 -LRB- denotes (
T7594 10640-10643 NN denotes BMI
T7595 10644-10645 SYM denotes =
T7593 10646-10650 NN denotes WSAC
T7596 10650-10651 SYM denotes /
T7597 10651-10654 NN denotes NA2
T7598 10655-10656 SYM denotes *
T7599 10656-10659 NN denotes 100
T7600 10659-10660 -RRB- denotes )
T7601 10661-10664 IN denotes for
T7602 10665-10669 DT denotes each
T7604 10670-10674 NN denotes MMU2
T7605 10675-10683 JJ denotes congenic
T7603 10684-10690 NN denotes strain
T7606 10690-10691 . denotes .
T7607 10691-10804 sentence denotes Similar to large differences in body weight the B62D strain displayed highly significant decreases in adiposity.
T7608 10692-10699 JJ denotes Similar
T7610 10700-10702 IN denotes to
T7611 10703-10708 JJ denotes large
T7612 10709-10720 NNS denotes differences
T7613 10721-10723 IN denotes in
T7614 10724-10728 NN denotes body
T7615 10729-10735 NN denotes weight
T7616 10736-10739 DT denotes the
T7618 10740-10744 NN denotes B62D
T7617 10745-10751 NN denotes strain
T7609 10752-10761 VBD denotes displayed
T7619 10762-10768 RB denotes highly
T7620 10769-10780 JJ denotes significant
T7621 10781-10790 NNS denotes decreases
T7622 10791-10793 IN denotes in
T7623 10794-10803 NN denotes adiposity
T7624 10803-10804 . denotes .
T7625 10804-10891 sentence denotes B62D was the only strain where both sexes had significant decreases in TF, AI and BMI.
T7626 10805-10809 NN denotes B62D
T7627 10810-10813 VBD denotes was
T7628 10814-10817 DT denotes the
T7630 10818-10822 JJ denotes only
T7629 10823-10829 NN denotes strain
T7631 10830-10835 WRB denotes where
T7633 10836-10840 DT denotes both
T7634 10841-10846 NNS denotes sexes
T7632 10847-10850 VBD denotes had
T7635 10851-10862 JJ denotes significant
T7636 10863-10872 NNS denotes decreases
T7637 10873-10875 IN denotes in
T7638 10876-10878 NN denotes TF
T7639 10878-10880 , denotes ,
T7640 10880-10882 NN denotes AI
T7641 10883-10886 CC denotes and
T7642 10887-10890 NN denotes BMI
T7643 10890-10891 . denotes .
T7644 10891-10956 sentence denotes Interestingly, no difference in adiposity was seen in B62M mice.
T7645 10892-10905 RB denotes Interestingly
T7647 10905-10907 , denotes ,
T7648 10907-10909 DT denotes no
T7649 10910-10920 NN denotes difference
T7650 10921-10923 IN denotes in
T7651 10924-10933 NN denotes adiposity
T7652 10934-10937 VBD denotes was
T7646 10938-10942 VBN denotes seen
T7653 10943-10945 IN denotes in
T7654 10946-10950 NN denotes B62M
T7655 10951-10955 NNS denotes mice
T7656 10955-10956 . denotes .
T7657 10956-11059 sentence denotes This discordance indicates the leanness promoting QTL is located in the B62D unique region (Region V).
T7658 10957-10961 DT denotes This
T7659 10962-10973 NN denotes discordance
T7660 10974-10983 VBZ denotes indicates
T7661 10984-10987 DT denotes the
T7663 10988-10996 NN denotes leanness
T7664 10997-11006 VBG denotes promoting
T7662 11007-11010 NN denotes QTL
T7666 11011-11013 VBZ denotes is
T7665 11014-11021 VBN denotes located
T7667 11022-11024 IN denotes in
T7668 11025-11028 DT denotes the
T7670 11029-11033 NN denotes B62D
T7671 11034-11040 JJ denotes unique
T7669 11041-11047 NN denotes region
T7672 11048-11049 -LRB- denotes (
T7673 11049-11055 NN denotes Region
T7674 11056-11057 CD denotes V
T7675 11057-11058 -RRB- denotes )
T7676 11058-11059 . denotes .
T7677 11059-11165 sentence denotes Only minor differences in various fat pad weights were observed for the B62P and B62PM strains (Table 2).
T7678 11060-11064 RB denotes Only
T7680 11065-11070 JJ denotes minor
T7679 11071-11082 NNS denotes differences
T7682 11083-11085 IN denotes in
T7683 11086-11093 JJ denotes various
T7685 11094-11097 NN denotes fat
T7686 11098-11101 NN denotes pad
T7684 11102-11109 NNS denotes weights
T7687 11110-11114 VBD denotes were
T7681 11115-11123 VBN denotes observed
T7688 11124-11127 IN denotes for
T7689 11128-11131 DT denotes the
T7691 11132-11136 NN denotes B62P
T7692 11137-11140 CC denotes and
T7693 11141-11146 NN denotes B62PM
T7690 11147-11154 NNS denotes strains
T7694 11155-11156 -LRB- denotes (
T7695 11156-11161 NN denotes Table
T7696 11162-11163 CD denotes 2
T7697 11163-11164 -RRB- denotes )
T7698 11164-11165 . denotes .
T7699 11165-11200 sentence denotes HG.CAST MMU2 speed congenic panel
T7700 11167-11174 NN denotes HG.CAST
T7701 11175-11179 NN denotes MMU2
T7703 11180-11185 NN denotes speed
T7704 11186-11194 JJ denotes congenic
T7702 11195-11200 NN denotes panel
T7705 11200-11334 sentence denotes HG2P and HG2PM mice of both sexes displayed significant decreases in post-weaning body weights and growth rates (Additional Table 3).
T7706 11201-11205 NN denotes HG2P
T7708 11206-11209 CC denotes and
T7709 11210-11215 NN denotes HG2PM
T7707 11216-11220 NNS denotes mice
T7711 11221-11223 IN denotes of
T7712 11224-11228 DT denotes both
T7713 11229-11234 NNS denotes sexes
T7710 11235-11244 VBD denotes displayed
T7714 11245-11256 JJ denotes significant
T7715 11257-11266 NNS denotes decreases
T7716 11267-11269 IN denotes in
T7717 11270-11282 JJ denotes post-weaning
T7719 11283-11287 NN denotes body
T7718 11288-11295 NNS denotes weights
T7720 11296-11299 CC denotes and
T7721 11300-11306 NN denotes growth
T7722 11307-11312 NNS denotes rates
T7723 11313-11314 -LRB- denotes (
T7725 11314-11324 JJ denotes Additional
T7724 11325-11330 NN denotes Table
T7726 11331-11332 CD denotes 3
T7727 11332-11333 -RRB- denotes )
T7728 11333-11334 . denotes .
T7729 11334-11445 sentence denotes In addition, the HG2M strain displayed highly significant decreases in length, similar to B62M mice (Table 2).
T7730 11335-11337 IN denotes In
T7732 11338-11346 NN denotes addition
T7733 11346-11348 , denotes ,
T7734 11348-11351 DT denotes the
T7736 11352-11356 NN denotes HG2M
T7735 11357-11363 NN denotes strain
T7731 11364-11373 VBD denotes displayed
T7737 11374-11380 RB denotes highly
T7738 11381-11392 JJ denotes significant
T7739 11393-11402 NNS denotes decreases
T7740 11403-11405 IN denotes in
T7741 11406-11412 NN denotes length
T7742 11412-11414 , denotes ,
T7743 11414-11421 JJ denotes similar
T7744 11422-11424 IN denotes to
T7745 11425-11429 NN denotes B62M
T7746 11430-11434 NNS denotes mice
T7747 11435-11436 -LRB- denotes (
T7748 11436-11441 NN denotes Table
T7749 11442-11443 CD denotes 2
T7750 11443-11444 -RRB- denotes )
T7751 11444-11445 . denotes .
T7752 11445-11657 sentence denotes These results indicate QTL within Region II shared between the HG2P and HG2PM strains decrease body size, weight gain and NA (only in females), while a QTL in the HG2M region significantly decreases tail length.
T7753 11446-11451 DT denotes These
T7754 11452-11459 NNS denotes results
T7755 11460-11468 VBP denotes indicate
T7756 11469-11472 NN denotes QTL
T7758 11473-11479 IN denotes within
T7759 11480-11486 NN denotes Region
T7760 11487-11489 CD denotes II
T7761 11490-11496 VBN denotes shared
T7762 11497-11504 IN denotes between
T7763 11505-11508 DT denotes the
T7765 11509-11513 NN denotes HG2P
T7766 11514-11517 CC denotes and
T7767 11518-11523 NN denotes HG2PM
T7764 11524-11531 NNS denotes strains
T7757 11532-11540 VBP denotes decrease
T7768 11541-11545 NN denotes body
T7769 11546-11550 NN denotes size
T7770 11550-11552 , denotes ,
T7771 11552-11558 NN denotes weight
T7772 11559-11563 NN denotes gain
T7773 11564-11567 CC denotes and
T7774 11568-11570 NN denotes NA
T7775 11571-11572 -LRB- denotes (
T7776 11572-11576 RB denotes only
T7777 11577-11579 IN denotes in
T7778 11580-11587 NNS denotes females
T7779 11587-11588 -RRB- denotes )
T7780 11588-11590 , denotes ,
T7781 11590-11595 IN denotes while
T7783 11596-11597 DT denotes a
T7784 11598-11601 NN denotes QTL
T7785 11602-11604 IN denotes in
T7786 11605-11608 DT denotes the
T7788 11609-11613 NN denotes HG2M
T7787 11614-11620 NN denotes region
T7789 11621-11634 RB denotes significantly
T7782 11635-11644 VBZ denotes decreases
T7790 11645-11649 NN denotes tail
T7791 11650-11656 NN denotes length
T7792 11656-11657 . denotes .
T7793 11657-11785 sentence denotes Similar to growth traits a general decrease in GFP, MFP, RFP, TF and AI were seen in HG2P and HG2PM mice (Region II) (Table 2).
T7794 11658-11665 JJ denotes Similar
T7796 11666-11668 IN denotes to
T7797 11669-11675 NN denotes growth
T7798 11676-11682 NNS denotes traits
T7799 11683-11684 DT denotes a
T7801 11685-11692 JJ denotes general
T7800 11693-11701 NN denotes decrease
T7802 11702-11704 IN denotes in
T7803 11705-11708 NN denotes GFP
T7804 11708-11710 , denotes ,
T7805 11710-11713 NN denotes MFP
T7806 11713-11715 , denotes ,
T7807 11715-11718 NN denotes RFP
T7808 11718-11720 , denotes ,
T7809 11720-11722 NN denotes TF
T7810 11723-11726 CC denotes and
T7811 11727-11729 NN denotes AI
T7812 11730-11734 VBD denotes were
T7795 11735-11739 VBN denotes seen
T7813 11740-11742 IN denotes in
T7814 11743-11747 NN denotes HG2P
T7816 11748-11751 CC denotes and
T7817 11752-11757 NN denotes HG2PM
T7815 11758-11762 NNS denotes mice
T7818 11763-11764 -LRB- denotes (
T7819 11764-11770 NN denotes Region
T7820 11771-11773 CD denotes II
T7821 11773-11774 -RRB- denotes )
T7822 11775-11776 -LRB- denotes (
T7823 11776-11781 NN denotes Table
T7824 11782-11783 CD denotes 2
T7825 11783-11784 -RRB- denotes )
T7826 11784-11785 . denotes .
T7827 11785-11899 sentence denotes These differences in adiposity are likely pleiotropic effects of the growth QTL shared between these two strains.
T7828 11786-11791 DT denotes These
T7829 11792-11803 NNS denotes differences
T7831 11804-11806 IN denotes in
T7832 11807-11816 NN denotes adiposity
T7830 11817-11820 VBP denotes are
T7833 11821-11827 RB denotes likely
T7834 11828-11839 JJ denotes pleiotropic
T7835 11840-11847 NNS denotes effects
T7836 11848-11850 IN denotes of
T7837 11851-11854 DT denotes the
T7839 11855-11861 NN denotes growth
T7838 11862-11865 NN denotes QTL
T7840 11866-11872 VBN denotes shared
T7841 11873-11880 IN denotes between
T7842 11881-11886 DT denotes these
T7844 11887-11890 CD denotes two
T7843 11891-11898 NNS denotes strains
T7845 11898-11899 . denotes .
T7846 11899-11972 sentence denotes Surprisingly, HG2M mice displayed striking sex differences in adiposity.
T7847 11900-11912 RB denotes Surprisingly
T7849 11912-11914 , denotes ,
T7850 11914-11918 NN denotes HG2M
T7851 11919-11923 NNS denotes mice
T7848 11924-11933 VBD denotes displayed
T7852 11934-11942 JJ denotes striking
T7854 11943-11946 NN denotes sex
T7853 11947-11958 NNS denotes differences
T7855 11959-11961 IN denotes in
T7856 11962-11971 NN denotes adiposity
T7857 11971-11972 . denotes .
T7858 11972-12143 sentence denotes Males exhibited an increase in AI (P = 0.0256) with a decrease in BMI (P = 0.0462) and the exact opposite was seen in females (AI, P < 0.0001; BMI, P = 0.0425) (Table 2).
T7859 11973-11978 NNS denotes Males
T7860 11979-11988 VBD denotes exhibited
T7861 11989-11991 DT denotes an
T7862 11992-12000 NN denotes increase
T7863 12001-12003 IN denotes in
T7864 12004-12006 NN denotes AI
T7865 12007-12008 -LRB- denotes (
T7867 12008-12009 NN denotes P
T7868 12010-12011 SYM denotes =
T7866 12012-12018 CD denotes 0.0256
T7869 12018-12019 -RRB- denotes )
T7870 12020-12024 IN denotes with
T7871 12025-12026 DT denotes a
T7872 12027-12035 NN denotes decrease
T7873 12036-12038 IN denotes in
T7874 12039-12042 NN denotes BMI
T7875 12043-12044 -LRB- denotes (
T7877 12044-12045 NN denotes P
T7878 12046-12047 SYM denotes =
T7876 12048-12054 CD denotes 0.0462
T7879 12054-12055 -RRB- denotes )
T7880 12056-12059 CC denotes and
T7881 12060-12063 DT denotes the
T7883 12064-12069 JJ denotes exact
T7882 12070-12078 NN denotes opposite
T7885 12079-12082 VBD denotes was
T7884 12083-12087 VBN denotes seen
T7886 12088-12090 IN denotes in
T7887 12091-12098 NNS denotes females
T7888 12099-12100 -LRB- denotes (
T7890 12100-12102 NN denotes AI
T7892 12102-12104 , denotes ,
T7893 12104-12105 NN denotes P
T7894 12106-12107 SYM denotes <
T7891 12108-12114 CD denotes 0.0001
T7895 12114-12115 : denotes ;
T7896 12116-12119 NN denotes BMI
T7897 12119-12121 , denotes ,
T7898 12121-12122 NN denotes P
T7899 12123-12124 SYM denotes =
T7889 12125-12131 CD denotes 0.0425
T7900 12131-12132 -RRB- denotes )
T7901 12133-12134 -LRB- denotes (
T7902 12134-12139 NN denotes Table
T7903 12140-12141 CD denotes 2
T7904 12141-12142 -RRB- denotes )
T7905 12142-12143 . denotes .
T7906 12143-12254 sentence denotes Therefore, the obesity QTL in the HG2M unique region (Region IV) is profoundly impacted by the presence of hg.
T7907 12144-12153 RB denotes Therefore
T7909 12153-12155 , denotes ,
T7910 12155-12158 DT denotes the
T7912 12159-12166 NN denotes obesity
T7911 12167-12170 NN denotes QTL
T7913 12171-12173 IN denotes in
T7914 12174-12177 DT denotes the
T7916 12178-12182 NN denotes HG2M
T7917 12183-12189 JJ denotes unique
T7915 12190-12196 NN denotes region
T7918 12197-12198 -LRB- denotes (
T7919 12198-12204 NN denotes Region
T7920 12205-12207 CD denotes IV
T7921 12207-12208 -RRB- denotes )
T7922 12209-12211 VBZ denotes is
T7923 12212-12222 RB denotes profoundly
T7908 12223-12231 VBN denotes impacted
T7924 12232-12234 IN denotes by
T7925 12235-12238 DT denotes the
T7926 12239-12247 NN denotes presence
T7927 12248-12250 IN denotes of
T7928 12251-12253 NN denotes hg
T7929 12253-12254 . denotes .
T7930 12254-12291 sentence denotes Confirmation of QTL-hg interactions
T7931 12256-12268 NN denotes Confirmation
T7932 12269-12271 IN denotes of
T7933 12272-12275 NN denotes QTL
T7935 12275-12276 HYPH denotes -
T7934 12276-12278 NN denotes hg
T7936 12279-12291 NNS denotes interactions
T7937 12291-12549 sentence denotes An important feature of our experimental design was the ability to test for interactions between QTL in each MMU2 donor region and genotype at the HG locus, since identical donor regions were introgressed on two genetic backgrounds, B6 (+/+) and HG (hg/hg).
T7938 12292-12294 DT denotes An
T7940 12295-12304 JJ denotes important
T7939 12305-12312 NN denotes feature
T7942 12313-12315 IN denotes of
T7943 12316-12319 PRP$ denotes our
T7945 12320-12332 JJ denotes experimental
T7944 12333-12339 NN denotes design
T7941 12340-12343 VBD denotes was
T7946 12344-12347 DT denotes the
T7947 12348-12355 NN denotes ability
T7948 12356-12358 TO denotes to
T7949 12359-12363 VB denotes test
T7950 12364-12367 IN denotes for
T7951 12368-12380 NNS denotes interactions
T7952 12381-12388 IN denotes between
T7953 12389-12392 NN denotes QTL
T7954 12393-12395 IN denotes in
T7955 12396-12400 DT denotes each
T7957 12401-12405 NN denotes MMU2
T7958 12406-12411 NN denotes donor
T7956 12412-12418 NN denotes region
T7959 12419-12422 CC denotes and
T7960 12423-12431 VB denotes genotype
T7961 12432-12434 IN denotes at
T7962 12435-12438 DT denotes the
T7964 12439-12441 NN denotes HG
T7963 12442-12447 NN denotes locus
T7965 12447-12449 , denotes ,
T7966 12449-12454 IN denotes since
T7968 12455-12464 JJ denotes identical
T7970 12465-12470 NN denotes donor
T7969 12471-12478 NNS denotes regions
T7971 12479-12483 VBD denotes were
T7967 12484-12496 VBN denotes introgressed
T7972 12497-12499 IN denotes on
T7973 12500-12503 CD denotes two
T7975 12504-12511 JJ denotes genetic
T7974 12512-12523 NNS denotes backgrounds
T7976 12523-12525 , denotes ,
T7977 12525-12527 NN denotes B6
T7978 12528-12529 -LRB- denotes (
T7980 12529-12530 SYM denotes +
T7981 12530-12531 HYPH denotes /
T7979 12531-12532 SYM denotes +
T7982 12532-12533 -RRB- denotes )
T7983 12534-12537 CC denotes and
T7984 12538-12540 NN denotes HG
T7985 12541-12542 -LRB- denotes (
T7987 12542-12544 NN denotes hg
T7988 12544-12545 HYPH denotes /
T7986 12545-12547 NN denotes hg
T7989 12547-12548 -RRB- denotes )
T7990 12548-12549 . denotes .
T7991 12549-12705 sentence denotes Significant interactions between donor region and HG genotype were viewed as strong evidence that hg modifier QTL reside within that unique genomic region.
T7992 12550-12561 JJ denotes Significant
T7993 12562-12574 NNS denotes interactions
T7995 12575-12582 IN denotes between
T7996 12583-12588 NN denotes donor
T7997 12589-12595 NN denotes region
T7998 12596-12599 CC denotes and
T7999 12600-12602 NN denotes HG
T8000 12603-12611 NN denotes genotype
T8001 12612-12616 VBD denotes were
T7994 12617-12623 VBN denotes viewed
T8002 12624-12626 IN denotes as
T8003 12627-12633 JJ denotes strong
T8004 12634-12642 NN denotes evidence
T8005 12643-12647 IN denotes that
T8007 12648-12650 NN denotes hg
T8009 12651-12659 NN denotes modifier
T8008 12660-12663 NN denotes QTL
T8006 12664-12670 VBP denotes reside
T8010 12671-12677 IN denotes within
T8011 12678-12682 DT denotes that
T8013 12683-12689 JJ denotes unique
T8014 12690-12697 JJ denotes genomic
T8012 12698-12704 NN denotes region
T8015 12704-12705 . denotes .
T8016 12705-12840 sentence denotes In the original linkage analysis the mode of gene action and peak location of Wg2 were dependent on the presence of hg [24] (Table 1).
T8017 12706-12708 IN denotes In
T8019 12709-12712 DT denotes the
T8021 12713-12721 JJ denotes original
T8022 12722-12729 NN denotes linkage
T8020 12730-12738 NN denotes analysis
T8023 12739-12742 DT denotes the
T8024 12743-12747 NN denotes mode
T8025 12748-12750 IN denotes of
T8026 12751-12755 NN denotes gene
T8027 12756-12762 NN denotes action
T8028 12763-12766 CC denotes and
T8029 12767-12771 JJ denotes peak
T8030 12772-12780 NN denotes location
T8031 12781-12783 IN denotes of
T8032 12784-12787 NN denotes Wg2
T8018 12788-12792 VBD denotes were
T8033 12793-12802 JJ denotes dependent
T8034 12803-12805 IN denotes on
T8035 12806-12809 DT denotes the
T8036 12810-12818 NN denotes presence
T8037 12819-12821 IN denotes of
T8038 12822-12824 NN denotes hg
T8039 12825-12826 -LRB- denotes [
T8040 12826-12828 CD denotes 24
T8041 12828-12829 -RRB- denotes ]
T8042 12830-12831 -LRB- denotes (
T8043 12831-12836 NN denotes Table
T8044 12837-12838 CD denotes 1
T8045 12838-12839 -RRB- denotes )
T8046 12839-12840 . denotes .
T8047 12840-12967 sentence denotes In the present study, only homozygous congenic mice were characterized, thus, the overdominant effects of Wg2 were not tested.
T8048 12841-12843 IN denotes In
T8050 12844-12847 DT denotes the
T8052 12848-12855 JJ denotes present
T8051 12856-12861 NN denotes study
T8053 12861-12863 , denotes ,
T8054 12863-12867 RB denotes only
T8056 12868-12878 JJ denotes homozygous
T8057 12879-12887 JJ denotes congenic
T8055 12888-12892 NNS denotes mice
T8059 12893-12897 VBD denotes were
T8058 12898-12911 VBN denotes characterized
T8060 12911-12913 , denotes ,
T8061 12913-12917 RB denotes thus
T8062 12917-12919 , denotes ,
T8063 12919-12922 DT denotes the
T8065 12923-12935 JJ denotes overdominant
T8064 12936-12943 NNS denotes effects
T8066 12944-12946 IN denotes of
T8067 12947-12950 NN denotes Wg2
T8068 12951-12955 VBD denotes were
T8069 12956-12959 RB denotes not
T8049 12960-12966 VBN denotes tested
T8070 12966-12967 . denotes .
T8071 12967-13208 sentence denotes However, since its original peak location differed dependent on background we hypothesized that Wg2 represents a set of linked QTL between 74.9 and 181.8 Mbp within the 2M and 2D donor regions (Region III–V), some of which interact with hg.
T8072 12968-12975 RB denotes However
T8074 12975-12977 , denotes ,
T8075 12977-12982 IN denotes since
T8077 12983-12986 PRP$ denotes its
T8079 12987-12995 JJ denotes original
T8080 12996-13000 NN denotes peak
T8078 13001-13009 NN denotes location
T8076 13010-13018 VBD denotes differed
T8081 13019-13028 RB denotes dependent
T8082 13029-13031 IN denotes on
T8083 13032-13042 NN denotes background
T8084 13043-13045 PRP denotes we
T8073 13046-13058 VBD denotes hypothesized
T8085 13059-13063 IN denotes that
T8087 13064-13067 NN denotes Wg2
T8086 13068-13078 VBZ denotes represents
T8088 13079-13080 DT denotes a
T8089 13081-13084 NN denotes set
T8090 13085-13087 IN denotes of
T8091 13088-13094 VBN denotes linked
T8092 13095-13098 NN denotes QTL
T8093 13099-13106 IN denotes between
T8094 13107-13111 CD denotes 74.9
T8096 13112-13115 CC denotes and
T8097 13116-13121 CD denotes 181.8
T8095 13122-13125 NN denotes Mbp
T8098 13126-13132 IN denotes within
T8099 13133-13136 DT denotes the
T8101 13137-13139 NN denotes 2M
T8102 13140-13143 CC denotes and
T8103 13144-13146 NN denotes 2D
T8104 13147-13152 NN denotes donor
T8100 13153-13160 NNS denotes regions
T8105 13161-13162 -LRB- denotes (
T8106 13162-13168 NN denotes Region
T8107 13169-13172 CD denotes III
T8108 13172-13173 SYM denotes –
T8109 13173-13174 CD denotes V
T8110 13174-13175 -RRB- denotes )
T8111 13175-13177 , denotes ,
T8112 13177-13181 DT denotes some
T8114 13182-13184 IN denotes of
T8115 13185-13190 WDT denotes which
T8113 13191-13199 VBP denotes interact
T8116 13200-13204 IN denotes with
T8117 13205-13207 NN denotes hg
T8118 13207-13208 . denotes .
T8119 13208-13326 sentence denotes Following this logic we expected one or both of these strains would exhibit donor region by HG genotype interactions.
T8120 13209-13218 VBG denotes Following
T8122 13219-13223 DT denotes this
T8123 13224-13229 NN denotes logic
T8124 13230-13232 PRP denotes we
T8121 13233-13241 VBD denotes expected
T8125 13242-13245 CD denotes one
T8127 13246-13248 CC denotes or
T8128 13249-13253 DT denotes both
T8129 13254-13256 IN denotes of
T8130 13257-13262 DT denotes these
T8131 13263-13270 NNS denotes strains
T8132 13271-13276 MD denotes would
T8126 13277-13284 VB denotes exhibit
T8133 13285-13290 NN denotes donor
T8134 13291-13297 NN denotes region
T8136 13298-13300 IN denotes by
T8137 13301-13303 NN denotes HG
T8138 13304-13312 NN denotes genotype
T8135 13313-13325 NNS denotes interactions
T8139 13325-13326 . denotes .
T8140 13326-13383 sentence denotes Unfortunately, we were unable to characterize HG2D mice.
T8141 13327-13340 RB denotes Unfortunately
T8143 13340-13342 , denotes ,
T8144 13342-13344 PRP denotes we
T8142 13345-13349 VBD denotes were
T8145 13350-13356 JJ denotes unable
T8146 13357-13359 TO denotes to
T8147 13360-13372 VB denotes characterize
T8148 13373-13377 NN denotes HG2D
T8149 13378-13382 NNS denotes mice
T8150 13382-13383 . denotes .
T8151 13383-13460 sentence denotes However, as noted above, strong sex-specific effects were seen in HG2M mice.
T8152 13384-13391 RB denotes However
T8154 13391-13393 , denotes ,
T8155 13393-13395 IN denotes as
T8156 13396-13401 VBN denotes noted
T8157 13402-13407 RB denotes above
T8158 13407-13409 , denotes ,
T8159 13409-13415 JJ denotes strong
T8161 13416-13419 NN denotes sex
T8163 13419-13420 HYPH denotes -
T8162 13420-13428 JJ denotes specific
T8160 13429-13436 NNS denotes effects
T8164 13437-13441 VBD denotes were
T8153 13442-13446 VBN denotes seen
T8165 13447-13449 IN denotes in
T8166 13450-13454 NN denotes HG2M
T8167 13455-13459 NNS denotes mice
T8168 13459-13460 . denotes .
T8169 13460-13597 sentence denotes Significant 2M donor region by HG genotype by sex three-way interactions for AI (P = 0.0004; Figure 4) and TF were identified (Table 3).
T8170 13461-13472 JJ denotes Significant
T8172 13473-13475 NN denotes 2M
T8174 13476-13481 NN denotes donor
T8173 13482-13488 NN denotes region
T8175 13489-13491 IN denotes by
T8176 13492-13494 NN denotes HG
T8177 13495-13503 NN denotes genotype
T8178 13504-13506 IN denotes by
T8179 13507-13510 NN denotes sex
T8180 13511-13516 CD denotes three
T8182 13516-13517 HYPH denotes -
T8181 13517-13520 NN denotes way
T8171 13521-13533 NNS denotes interactions
T8184 13534-13537 IN denotes for
T8185 13538-13540 NN denotes AI
T8186 13541-13542 -LRB- denotes (
T8188 13542-13543 NN denotes P
T8190 13544-13545 SYM denotes =
T8189 13546-13552 CD denotes 0.0004
T8191 13552-13553 : denotes ;
T8187 13554-13560 NN denotes Figure
T8192 13561-13562 CD denotes 4
T8193 13562-13563 -RRB- denotes )
T8194 13564-13567 CC denotes and
T8195 13568-13570 NN denotes TF
T8196 13571-13575 VBD denotes were
T8183 13576-13586 VBN denotes identified
T8197 13587-13588 -LRB- denotes (
T8198 13588-13593 NN denotes Table
T8199 13594-13595 CD denotes 3
T8200 13595-13596 -RRB- denotes )
T8201 13596-13597 . denotes .
T8202 13597-13758 sentence denotes The basis of these interactions was a decrease in HG2M female and an increase in HG2M male adiposity, with no differences in fat accumulation across B62M sexes.
T8203 13598-13601 DT denotes The
T8204 13602-13607 NN denotes basis
T8206 13608-13610 IN denotes of
T8207 13611-13616 DT denotes these
T8208 13617-13629 NNS denotes interactions
T8205 13630-13633 VBD denotes was
T8209 13634-13635 DT denotes a
T8210 13636-13644 NN denotes decrease
T8211 13645-13647 IN denotes in
T8212 13648-13652 NN denotes HG2M
T8213 13653-13659 NN denotes female
T8214 13660-13663 CC denotes and
T8215 13664-13666 DT denotes an
T8216 13667-13675 NN denotes increase
T8218 13676-13678 IN denotes in
T8219 13679-13683 NN denotes HG2M
T8220 13684-13688 JJ denotes male
T8217 13689-13698 NN denotes adiposity
T8221 13698-13700 , denotes ,
T8222 13700-13704 IN denotes with
T8223 13705-13707 DT denotes no
T8224 13708-13719 NNS denotes differences
T8225 13720-13722 IN denotes in
T8226 13723-13726 NN denotes fat
T8227 13727-13739 NN denotes accumulation
T8228 13740-13746 IN denotes across
T8229 13747-13751 NN denotes B62M
T8230 13752-13757 NNS denotes sexes
T8231 13757-13758 . denotes .
T8232 13758-13916 sentence denotes Significant 2PM donor region by HG genotype two-way and 2PM donor region by HG genotype by sex three-way interactions were also seen for TF and AI (Table 3).
T8233 13759-13770 JJ denotes Significant
T8235 13771-13774 NN denotes 2PM
T8237 13775-13780 NN denotes donor
T8236 13781-13787 NN denotes region
T8239 13788-13790 IN denotes by
T8240 13791-13793 NN denotes HG
T8241 13794-13802 NN denotes genotype
T8242 13803-13806 CD denotes two
T8243 13806-13807 HYPH denotes -
T8238 13807-13810 NN denotes way
T8244 13811-13814 CC denotes and
T8245 13815-13818 NN denotes 2PM
T8247 13819-13824 NN denotes donor
T8246 13825-13831 NN denotes region
T8249 13832-13834 IN denotes by
T8250 13835-13837 NN denotes HG
T8251 13838-13846 NN denotes genotype
T8252 13847-13849 IN denotes by
T8253 13850-13853 NN denotes sex
T8254 13854-13859 CD denotes three
T8255 13859-13860 HYPH denotes -
T8248 13860-13863 NN denotes way
T8234 13864-13876 NNS denotes interactions
T8257 13877-13881 VBD denotes were
T8258 13882-13886 RB denotes also
T8256 13887-13891 VBN denotes seen
T8259 13892-13895 IN denotes for
T8260 13896-13898 NN denotes TF
T8261 13899-13902 CC denotes and
T8262 13903-13905 NN denotes AI
T8263 13906-13907 -LRB- denotes (
T8264 13907-13912 NN denotes Table
T8265 13913-13914 CD denotes 3
T8266 13914-13915 -RRB- denotes )
T8267 13915-13916 . denotes .
T8268 13916-14105 sentence denotes In addition, significant 2P donor region × HG genotype interactions were observed for all traits listed, although some traits did reached significance at the critical P < 0.0071 (Table 3).
T8269 13917-13919 IN denotes In
T8271 13920-13928 NN denotes addition
T8272 13928-13930 , denotes ,
T8273 13930-13941 JJ denotes significant
T8275 13942-13944 NN denotes 2P
T8277 13945-13950 NN denotes donor
T8276 13951-13957 NN denotes region
T8278 13958-13959 SYM denotes ×
T8280 13960-13962 NN denotes HG
T8279 13963-13971 NN denotes genotype
T8274 13972-13984 NNS denotes interactions
T8281 13985-13989 VBD denotes were
T8270 13990-13998 VBN denotes observed
T8282 13999-14002 IN denotes for
T8283 14003-14006 DT denotes all
T8284 14007-14013 NNS denotes traits
T8285 14014-14020 VBN denotes listed
T8286 14020-14022 , denotes ,
T8287 14022-14030 IN denotes although
T8289 14031-14035 DT denotes some
T8290 14036-14042 NNS denotes traits
T8291 14043-14046 VBD denotes did
T8288 14047-14054 VBN denotes reached
T8292 14055-14067 NN denotes significance
T8293 14068-14070 IN denotes at
T8294 14071-14074 DT denotes the
T8296 14075-14083 JJ denotes critical
T8297 14084-14085 NN denotes P
T8298 14086-14087 SYM denotes <
T8295 14088-14094 CD denotes 0.0071
T8299 14095-14096 -LRB- denotes (
T8300 14096-14101 NN denotes Table
T8301 14102-14103 CD denotes 3
T8302 14103-14104 -RRB- denotes )
T8303 14104-14105 . denotes .
T8304 14105-14228 sentence denotes The basis for each interaction was a decrease in phenotype in HG2P compared to HGC and no difference between B62P and B6C.
T8305 14106-14109 DT denotes The
T8306 14110-14115 NN denotes basis
T8308 14116-14119 IN denotes for
T8309 14120-14124 DT denotes each
T8310 14125-14136 NN denotes interaction
T8307 14137-14140 VBD denotes was
T8311 14141-14142 DT denotes a
T8312 14143-14151 NN denotes decrease
T8313 14152-14154 IN denotes in
T8314 14155-14164 NN denotes phenotype
T8315 14165-14167 IN denotes in
T8316 14168-14172 NN denotes HG2P
T8317 14173-14181 VBN denotes compared
T8318 14182-14184 IN denotes to
T8319 14185-14188 NN denotes HGC
T8320 14189-14192 CC denotes and
T8321 14193-14195 DT denotes no
T8322 14196-14206 NN denotes difference
T8323 14207-14214 IN denotes between
T8324 14215-14219 NN denotes B62P
T8325 14220-14223 CC denotes and
T8326 14224-14227 NN denotes B6C
T8327 14227-14228 . denotes .
T8328 14228-14309 sentence denotes Together these data confirm that MMU2 QTL modify the effects of the hg deletion.
T8329 14229-14237 RB denotes Together
T8331 14238-14243 DT denotes these
T8332 14244-14248 NNS denotes data
T8330 14249-14256 VBP denotes confirm
T8333 14257-14261 IN denotes that
T8335 14262-14266 NN denotes MMU2
T8336 14267-14270 NN denotes QTL
T8334 14271-14277 VBP denotes modify
T8337 14278-14281 DT denotes the
T8338 14282-14289 NNS denotes effects
T8339 14290-14292 IN denotes of
T8340 14293-14296 DT denotes the
T8342 14297-14299 NN denotes hg
T8341 14300-14308 NN denotes deletion
T8343 14308-14309 . denotes .
T11091 14311-14316 NN denotes Speed
T11092 14317-14325 JJ denotes congenic
T11093 14326-14333 NNS denotes strains
T11094 14334-14337 IN denotes for
T11095 14338-14341 NN denotes QTL
T11096 14342-14344 IN denotes on
T11097 14345-14348 NN denotes MMU
T11098 14348-14349 CD denotes 1
T11099 14349-14351 , denotes ,
T11100 14351-14352 CD denotes 8
T11101 14352-14354 , denotes ,
T11102 14354-14355 CD denotes 9
T11103 14355-14357 , denotes ,
T11104 14357-14359 CD denotes 11
T11105 14360-14363 CC denotes and
T11106 14364-14366 CD denotes 17
T11107 14366-14371 sentence denotes HG1
T11108 14368-14371 NN denotes HG1
T11109 14371-14548 sentence denotes Q1Ucd1 affecting G26 was the least significant of any QTL identified in the original intercross and only reached a suggestive level of significance (LOD = 2.46, P < 0.05) [26].
T11110 14372-14378 NN denotes Q1Ucd1
T11112 14379-14388 VBG denotes affecting
T11113 14389-14392 NN denotes G26
T11111 14393-14396 VBD denotes was
T11114 14397-14400 DT denotes the
T11116 14401-14406 JJS denotes least
T11115 14407-14418 JJ denotes significant
T11117 14419-14421 IN denotes of
T11118 14422-14425 DT denotes any
T11119 14426-14429 NN denotes QTL
T11120 14430-14440 VBN denotes identified
T11121 14441-14443 IN denotes in
T11122 14444-14447 DT denotes the
T11124 14448-14456 JJ denotes original
T11123 14457-14467 NN denotes intercross
T11125 14468-14471 CC denotes and
T11126 14472-14476 RB denotes only
T11127 14477-14484 VBD denotes reached
T11128 14485-14486 DT denotes a
T11130 14487-14497 JJ denotes suggestive
T11129 14498-14503 NN denotes level
T11131 14504-14506 IN denotes of
T11132 14507-14519 NN denotes significance
T11133 14520-14521 -LRB- denotes (
T11135 14521-14524 NN denotes LOD
T11137 14525-14526 SYM denotes =
T11136 14527-14531 CD denotes 2.46
T11138 14531-14533 , denotes ,
T11139 14533-14534 NN denotes P
T11140 14535-14536 SYM denotes <
T11134 14537-14541 CD denotes 0.05
T11141 14541-14542 -RRB- denotes )
T11142 14543-14544 -LRB- denotes [
T11143 14544-14546 CD denotes 26
T11144 14546-14547 -RRB- denotes ]
T11145 14547-14548 . denotes .
T11146 14548-14627 sentence denotes In accordance, HG1 mice had small differences in all growth and length traits.
T11147 14549-14551 IN denotes In
T11149 14552-14562 NN denotes accordance
T11150 14562-14564 , denotes ,
T11151 14564-14567 NN denotes HG1
T11152 14568-14572 NNS denotes mice
T11148 14573-14576 VBD denotes had
T11153 14577-14582 JJ denotes small
T11154 14583-14594 NNS denotes differences
T11155 14595-14597 IN denotes in
T11156 14598-14601 DT denotes all
T11158 14602-14608 NN denotes growth
T11159 14609-14612 CC denotes and
T11160 14613-14619 NN denotes length
T11157 14620-14626 NNS denotes traits
T11161 14626-14627 . denotes .
T11162 14627-14740 sentence denotes NA in both sexes and 2WK, 3WK, 6WK and tail length in females was significant at a critical P < 0.005 (Table 4).
T11163 14628-14630 NN denotes NA
T11165 14631-14633 IN denotes in
T11166 14634-14638 CC denotes both
T11167 14639-14644 NNS denotes sexes
T11168 14645-14648 CC denotes and
T11169 14649-14652 NN denotes 2WK
T11171 14652-14654 , denotes ,
T11172 14654-14657 NN denotes 3WK
T11173 14657-14659 , denotes ,
T11170 14659-14662 NN denotes 6WK
T11174 14663-14666 CC denotes and
T11175 14667-14671 NN denotes tail
T11176 14672-14678 NN denotes length
T11177 14679-14681 IN denotes in
T11178 14682-14689 NNS denotes females
T11164 14690-14693 VBD denotes was
T11179 14694-14705 JJ denotes significant
T11180 14706-14708 IN denotes at
T11181 14709-14710 DT denotes a
T11183 14711-14719 JJ denotes critical
T11184 14720-14721 NN denotes P
T11185 14722-14723 SYM denotes <
T11182 14724-14729 CD denotes 0.005
T11186 14730-14731 -LRB- denotes (
T11187 14731-14736 NN denotes Table
T11188 14737-14738 CD denotes 4
T11189 14738-14739 -RRB- denotes )
T11190 14739-14740 . denotes .
T11191 14740-14823 sentence denotes The only difference in adiposity was a significant decrease in male MFP (Table 5).
T11192 14741-14744 DT denotes The
T11194 14745-14749 JJ denotes only
T11193 14750-14760 NN denotes difference
T11196 14761-14763 IN denotes in
T11197 14764-14773 NN denotes adiposity
T11195 14774-14777 VBD denotes was
T11198 14778-14779 DT denotes a
T11200 14780-14791 JJ denotes significant
T11199 14792-14800 NN denotes decrease
T11201 14801-14803 IN denotes in
T11202 14804-14808 JJ denotes male
T11203 14809-14812 NN denotes MFP
T11204 14813-14814 -LRB- denotes (
T11205 14814-14819 NN denotes Table
T11206 14820-14821 CD denotes 5
T11207 14821-14822 -RRB- denotes )
T11208 14822-14823 . denotes .
T11209 14823-15004 sentence denotes The successful capture and confirmation of the small effect Q1Ucd1-w26 QTL adds support to pursuing QTL identified at suggestive levels of statistical confidence from genome scans.
T11210 14824-14827 DT denotes The
T11212 14828-14838 JJ denotes successful
T11211 14839-14846 NN denotes capture
T11214 14847-14850 CC denotes and
T11215 14851-14863 NN denotes confirmation
T11216 14864-14866 IN denotes of
T11217 14867-14870 DT denotes the
T11219 14871-14876 JJ denotes small
T11220 14877-14883 NN denotes effect
T11221 14884-14890 NN denotes Q1Ucd1
T11223 14890-14891 HYPH denotes -
T11222 14891-14894 NN denotes w26
T11218 14895-14898 NN denotes QTL
T11213 14899-14903 VBZ denotes adds
T11224 14904-14911 NN denotes support
T11225 14912-14914 IN denotes to
T11226 14915-14923 VBG denotes pursuing
T11227 14924-14927 NN denotes QTL
T11228 14928-14938 VBN denotes identified
T11229 14939-14941 IN denotes at
T11230 14942-14952 JJ denotes suggestive
T11231 14953-14959 NNS denotes levels
T11232 14960-14962 IN denotes of
T11233 14963-14974 JJ denotes statistical
T11234 14975-14985 NN denotes confidence
T11235 14986-14990 IN denotes from
T11236 14991-14997 NN denotes genome
T11237 14998-15003 NNS denotes scans
T11238 15003-15004 . denotes .
T11239 15004-15009 sentence denotes HG8
T11240 15006-15009 NN denotes HG8
T11241 15009-15079 sentence denotes Markers on MMU8 were linked with G29 in the original intercross [24].
T11242 15010-15017 NNS denotes Markers
T11244 15018-15020 IN denotes on
T11245 15021-15025 NN denotes MMU8
T11246 15026-15030 VBD denotes were
T11243 15031-15037 VBN denotes linked
T11247 15038-15042 IN denotes with
T11248 15043-15046 NN denotes G29
T11249 15047-15049 IN denotes in
T11250 15050-15053 DT denotes the
T11252 15054-15062 JJ denotes original
T11251 15063-15073 NN denotes intercross
T11253 15074-15075 -LRB- denotes [
T11254 15075-15077 CD denotes 24
T11255 15077-15078 -RRB- denotes ]
T11256 15078-15079 . denotes .
T11257 15079-15152 sentence denotes This QTL was small, only accounting for 4.3% of the phenotypic variance.
T11258 15080-15084 DT denotes This
T11259 15085-15088 NN denotes QTL
T11260 15089-15092 VBD denotes was
T11261 15093-15098 JJ denotes small
T11262 15098-15100 , denotes ,
T11263 15100-15104 RB denotes only
T11264 15105-15115 VBG denotes accounting
T11265 15116-15119 IN denotes for
T11266 15120-15123 CD denotes 4.3
T11267 15123-15124 NN denotes %
T11268 15125-15127 IN denotes of
T11269 15128-15131 DT denotes the
T11271 15132-15142 JJ denotes phenotypic
T11270 15143-15151 NN denotes variance
T11272 15151-15152 . denotes .
T11273 15152-15284 sentence denotes Interestingly, in HG8 mice no differences in growth were detected; however, they were significantly leaner than controls (Table 5).
T11274 15153-15166 RB denotes Interestingly
T11276 15166-15168 , denotes ,
T11277 15168-15170 IN denotes in
T11278 15171-15174 NN denotes HG8
T11279 15175-15179 NNS denotes mice
T11280 15180-15182 DT denotes no
T11281 15183-15194 NNS denotes differences
T11282 15195-15197 IN denotes in
T11283 15198-15204 NN denotes growth
T11284 15205-15209 VBD denotes were
T11275 15210-15218 VBN denotes detected
T11286 15218-15219 : denotes ;
T11287 15220-15227 RB denotes however
T11288 15227-15229 , denotes ,
T11289 15229-15233 PRP denotes they
T11285 15234-15238 VBD denotes were
T11290 15239-15252 RB denotes significantly
T11291 15253-15259 JJR denotes leaner
T11292 15260-15264 IN denotes than
T11293 15265-15273 NNS denotes controls
T11294 15274-15275 -LRB- denotes (
T11295 15275-15280 NN denotes Table
T11296 15281-15282 CD denotes 5
T11297 15282-15283 -RRB- denotes )
T11298 15283-15284 . denotes .
T11299 15284-15412 sentence denotes In males a general decrease in fat pad mass, TF and AI was detected; however, only MFP was significant at a critical P < 0.005.
T11300 15285-15287 IN denotes In
T11302 15288-15293 NNS denotes males
T11303 15294-15295 DT denotes a
T11305 15296-15303 JJ denotes general
T11304 15304-15312 NN denotes decrease
T11307 15313-15315 IN denotes in
T11308 15316-15319 NN denotes fat
T11309 15320-15323 NN denotes pad
T11310 15324-15328 NN denotes mass
T11311 15328-15330 , denotes ,
T11312 15330-15332 NN denotes TF
T11313 15333-15336 CC denotes and
T11314 15337-15339 NN denotes AI
T11315 15340-15343 VBD denotes was
T11306 15344-15352 VBN denotes detected
T11316 15352-15353 : denotes ;
T11317 15354-15361 RB denotes however
T11318 15361-15363 , denotes ,
T11319 15363-15367 RB denotes only
T11320 15368-15371 NN denotes MFP
T11301 15372-15375 VBD denotes was
T11321 15376-15387 JJ denotes significant
T11322 15388-15390 IN denotes at
T11323 15391-15392 DT denotes a
T11325 15393-15401 JJ denotes critical
T11326 15402-15403 NN denotes P
T11327 15404-15405 SYM denotes <
T11324 15406-15411 CD denotes 0.005
T11328 15411-15412 . denotes .
T11329 15412-15468 sentence denotes Male AI was nearly significant at a nominal P = 0.0082.
T11330 15413-15417 JJ denotes Male
T11331 15418-15420 NN denotes AI
T11332 15421-15424 VBD denotes was
T11333 15425-15431 RB denotes nearly
T11334 15432-15443 JJ denotes significant
T11335 15444-15446 IN denotes at
T11336 15447-15448 DT denotes a
T11338 15449-15456 JJ denotes nominal
T11339 15457-15458 NN denotes P
T11340 15459-15460 SYM denotes =
T11337 15461-15467 CD denotes 0.0082
T11341 15467-15468 . denotes .
T11342 15468-15580 sentence denotes Larger decreases in fat mass were seen in HG8 females, with significant decreases detected for GFP, MFP and AI.
T11343 15469-15475 JJR denotes Larger
T11344 15476-15485 NNS denotes decreases
T11346 15486-15488 IN denotes in
T11347 15489-15492 NN denotes fat
T11348 15493-15497 NN denotes mass
T11349 15498-15502 VBD denotes were
T11345 15503-15507 VBN denotes seen
T11350 15508-15510 IN denotes in
T11351 15511-15514 NN denotes HG8
T11352 15515-15522 NNS denotes females
T11353 15522-15524 , denotes ,
T11354 15524-15528 IN denotes with
T11356 15529-15540 JJ denotes significant
T11357 15541-15550 NNS denotes decreases
T11355 15551-15559 VBN denotes detected
T11358 15560-15563 IN denotes for
T11359 15564-15567 NN denotes GFP
T11360 15567-15569 , denotes ,
T11361 15569-15572 NN denotes MFP
T11362 15573-15576 CC denotes and
T11363 15577-15579 NN denotes AI
T11364 15579-15580 . denotes .
T11365 15580-15687 sentence denotes Additionally, RFP and TF were nearly significant with nominal P values of 0.0208 and 0.0153, respectively.
T11366 15581-15593 RB denotes Additionally
T11368 15593-15595 , denotes ,
T11369 15595-15598 NN denotes RFP
T11370 15599-15602 CC denotes and
T11371 15603-15605 NN denotes TF
T11367 15606-15610 VBD denotes were
T11372 15611-15617 RB denotes nearly
T11373 15618-15629 JJ denotes significant
T11374 15630-15634 IN denotes with
T11375 15635-15642 JJ denotes nominal
T11377 15643-15644 NN denotes P
T11376 15645-15651 NNS denotes values
T11378 15652-15654 IN denotes of
T11379 15655-15661 CD denotes 0.0208
T11380 15662-15665 CC denotes and
T11381 15666-15672 CD denotes 0.0153
T11382 15672-15674 , denotes ,
T11383 15674-15686 RB denotes respectively
T11384 15686-15687 . denotes .
T11385 15687-15784 sentence denotes HG8 mice represent a lean congenic model in which CAST alleles protect against fat accumulation.
T11386 15688-15691 NN denotes HG8
T11387 15692-15696 NNS denotes mice
T11388 15697-15706 VBP denotes represent
T11389 15707-15708 DT denotes a
T11391 15709-15713 JJ denotes lean
T11392 15714-15722 JJ denotes congenic
T11390 15723-15728 NN denotes model
T11393 15729-15731 IN denotes in
T11395 15732-15737 WDT denotes which
T11396 15738-15742 NN denotes CAST
T11397 15743-15750 NNS denotes alleles
T11394 15751-15758 VBP denotes protect
T11398 15759-15766 IN denotes against
T11399 15767-15770 NN denotes fat
T11400 15771-15783 NN denotes accumulation
T11401 15783-15784 . denotes .
T11402 15784-15789 sentence denotes HG9
T11403 15786-15789 NN denotes HG9
T11404 15789-15945 sentence denotes CAST alleles in the proximal region of MMU9 were previously found to be linked with an increase in body fat percentage and a decrease in femur length [24].
T11405 15790-15794 NN denotes CAST
T11406 15795-15802 NNS denotes alleles
T11408 15803-15805 IN denotes in
T11409 15806-15809 DT denotes the
T11411 15810-15818 JJ denotes proximal
T11410 15819-15825 NN denotes region
T11412 15826-15828 IN denotes of
T11413 15829-15833 NN denotes MMU9
T11414 15834-15838 VBD denotes were
T11415 15839-15849 RB denotes previously
T11407 15850-15855 VBN denotes found
T11416 15856-15858 TO denotes to
T11418 15859-15861 VB denotes be
T11417 15862-15868 VBN denotes linked
T11419 15869-15873 IN denotes with
T11420 15874-15876 DT denotes an
T11421 15877-15885 NN denotes increase
T11422 15886-15888 IN denotes in
T11423 15889-15893 NN denotes body
T11424 15894-15897 NN denotes fat
T11425 15898-15908 NN denotes percentage
T11426 15909-15912 CC denotes and
T11427 15913-15914 DT denotes a
T11428 15915-15923 NN denotes decrease
T11429 15924-15926 IN denotes in
T11430 15927-15932 NN denotes femur
T11431 15933-15939 NN denotes length
T11432 15940-15941 -LRB- denotes [
T11433 15941-15943 CD denotes 24
T11434 15943-15944 -RRB- denotes ]
T11435 15944-15945 . denotes .
T11436 15945-16103 sentence denotes The effects appeared to be the result of two linked QTL, Carfhg2 at 10 cM and Feml2 at 20 cM, instead of one pleiotropically impacting both traits (Table 1).
T11437 15946-15949 DT denotes The
T11438 15950-15957 NNS denotes effects
T11439 15958-15966 VBD denotes appeared
T11440 15967-15969 TO denotes to
T11441 15970-15972 VB denotes be
T11442 15973-15976 DT denotes the
T11443 15977-15983 NN denotes result
T11444 15984-15986 IN denotes of
T11445 15987-15990 CD denotes two
T11447 15991-15997 VBN denotes linked
T11446 15998-16001 NN denotes QTL
T11448 16001-16003 , denotes ,
T11449 16003-16010 NN denotes Carfhg2
T11450 16011-16013 IN denotes at
T11451 16014-16016 CD denotes 10
T11452 16017-16019 NN denotes cM
T11453 16020-16023 CC denotes and
T11454 16024-16029 NN denotes Feml2
T11455 16030-16032 IN denotes at
T11456 16033-16035 CD denotes 20
T11457 16036-16038 NN denotes cM
T11458 16038-16040 , denotes ,
T11459 16040-16047 IN denotes instead
T11460 16048-16050 IN denotes of
T11461 16051-16054 CD denotes one
T11462 16055-16070 RB denotes pleiotropically
T11463 16071-16080 VBG denotes impacting
T11464 16081-16085 DT denotes both
T11465 16086-16092 NNS denotes traits
T11466 16093-16094 -LRB- denotes (
T11467 16094-16099 NN denotes Table
T11468 16100-16101 CD denotes 1
T11469 16101-16102 -RRB- denotes )
T11470 16102-16103 . denotes .
T11471 16103-16216 sentence denotes In support of this, the increase in fat was dependent on hg; however, differences in femur length were not [24].
T11472 16104-16106 IN denotes In
T11474 16107-16114 NN denotes support
T11475 16115-16117 IN denotes of
T11476 16118-16122 DT denotes this
T11477 16122-16124 , denotes ,
T11478 16124-16127 DT denotes the
T11479 16128-16136 NN denotes increase
T11480 16137-16139 IN denotes in
T11481 16140-16143 NN denotes fat
T11473 16144-16147 VBD denotes was
T11483 16148-16157 JJ denotes dependent
T11484 16158-16160 IN denotes on
T11485 16161-16163 NN denotes hg
T11486 16163-16164 : denotes ;
T11487 16165-16172 RB denotes however
T11488 16172-16174 , denotes ,
T11489 16174-16185 NNS denotes differences
T11490 16186-16188 IN denotes in
T11491 16189-16194 NN denotes femur
T11492 16195-16201 NN denotes length
T11482 16202-16206 VBD denotes were
T11493 16207-16210 RB denotes not
T11494 16211-16212 -LRB- denotes [
T11495 16212-16214 CD denotes 24
T11496 16214-16215 -RRB- denotes ]
T11497 16215-16216 . denotes .
T11498 16216-16375 sentence denotes In confirmation of Carfhg2 all measures of adiposity in HG9 mice were increased relative to control mice; except MFP in both sexes and BMI in males (Table 5).
T11499 16217-16219 IN denotes In
T11501 16220-16232 NN denotes confirmation
T11502 16233-16235 IN denotes of
T11503 16236-16243 NN denotes Carfhg2
T11504 16244-16247 DT denotes all
T11505 16248-16256 NNS denotes measures
T11506 16257-16259 IN denotes of
T11507 16260-16269 NN denotes adiposity
T11508 16270-16272 IN denotes in
T11509 16273-16276 NN denotes HG9
T11510 16277-16281 NNS denotes mice
T11511 16282-16286 VBD denotes were
T11500 16287-16296 VBN denotes increased
T11512 16297-16305 JJ denotes relative
T11513 16306-16308 IN denotes to
T11514 16309-16316 NN denotes control
T11515 16317-16321 NNS denotes mice
T11516 16321-16322 : denotes ;
T11517 16323-16329 IN denotes except
T11518 16330-16333 NN denotes MFP
T11519 16334-16336 IN denotes in
T11520 16337-16341 CC denotes both
T11521 16342-16347 NNS denotes sexes
T11522 16348-16351 CC denotes and
T11523 16352-16355 NN denotes BMI
T11524 16356-16358 IN denotes in
T11525 16359-16364 NNS denotes males
T11526 16365-16366 -LRB- denotes (
T11527 16366-16371 NN denotes Table
T11528 16372-16373 CD denotes 5
T11529 16373-16374 -RRB- denotes )
T11530 16374-16375 . denotes .
T11531 16375-16469 sentence denotes In males, GFP, RFP, FFP and AI were increased by 29.0%, 51.2%, 42.9% and 30.0%, respectively.
T11532 16376-16378 IN denotes In
T11534 16379-16384 NNS denotes males
T11535 16384-16386 , denotes ,
T11536 16386-16389 NN denotes GFP
T11537 16389-16391 , denotes ,
T11538 16391-16394 NN denotes RFP
T11539 16394-16396 , denotes ,
T11540 16396-16399 NN denotes FFP
T11541 16400-16403 CC denotes and
T11542 16404-16406 NN denotes AI
T11543 16407-16411 VBD denotes were
T11533 16412-16421 VBN denotes increased
T11544 16422-16424 IN denotes by
T11545 16425-16429 CD denotes 29.0
T11546 16429-16430 NN denotes %
T11547 16430-16432 , denotes ,
T11548 16432-16436 CD denotes 51.2
T11549 16436-16437 NN denotes %
T11550 16437-16439 , denotes ,
T11551 16439-16443 CD denotes 42.9
T11552 16443-16444 NN denotes %
T11553 16445-16448 CC denotes and
T11554 16449-16453 CD denotes 30.0
T11555 16453-16454 NN denotes %
T11556 16454-16456 , denotes ,
T11557 16456-16468 RB denotes respectively
T11558 16468-16469 . denotes .
T11559 16469-16514 sentence denotes In females these increases were much larger.
T11560 16470-16472 IN denotes In
T11562 16473-16480 NNS denotes females
T11563 16481-16486 DT denotes these
T11564 16487-16496 NNS denotes increases
T11561 16497-16501 VBD denotes were
T11565 16502-16506 RB denotes much
T11566 16507-16513 JJR denotes larger
T11567 16513-16514 . denotes .
T11568 16514-16610 sentence denotes The same measurements were increased by 68.8%, 99.4%, 69.7% and 57.3%, relative to HGC females.
T11569 16515-16518 DT denotes The
T11571 16519-16523 JJ denotes same
T11570 16524-16536 NNS denotes measurements
T11573 16537-16541 VBD denotes were
T11572 16542-16551 VBN denotes increased
T11574 16552-16554 IN denotes by
T11575 16555-16559 CD denotes 68.8
T11576 16559-16560 NN denotes %
T11577 16560-16562 , denotes ,
T11578 16562-16566 CD denotes 99.4
T11579 16566-16567 NN denotes %
T11580 16567-16569 , denotes ,
T11581 16569-16573 CD denotes 69.7
T11582 16573-16574 NN denotes %
T11583 16575-16578 CC denotes and
T11584 16579-16583 CD denotes 57.3
T11585 16583-16584 NN denotes %
T11586 16584-16586 , denotes ,
T11587 16586-16594 JJ denotes relative
T11588 16595-16597 IN denotes to
T11589 16598-16601 NN denotes HGC
T11590 16602-16609 NNS denotes females
T11591 16609-16610 . denotes .
T11592 16610-16692 sentence denotes A 2.9% and 3.6% reduction in male and female NA, respectively, was also detected.
T11593 16611-16612 DT denotes A
T11595 16613-16616 CD denotes 2.9
T11596 16616-16617 NN denotes %
T11597 16618-16621 CC denotes and
T11598 16622-16625 CD denotes 3.6
T11599 16625-16626 NN denotes %
T11594 16627-16636 NN denotes reduction
T11601 16637-16639 IN denotes in
T11602 16640-16644 JJ denotes male
T11604 16645-16648 CC denotes and
T11605 16649-16655 JJ denotes female
T11603 16656-16658 NN denotes NA
T11606 16658-16660 , denotes ,
T11607 16660-16672 RB denotes respectively
T11608 16672-16674 , denotes ,
T11609 16674-16677 VBD denotes was
T11610 16678-16682 RB denotes also
T11600 16683-16691 VBN denotes detected
T11611 16691-16692 . denotes .
T11612 16692-16873 sentence denotes This was expected since NA was previously found to be an excellent indicator of femur length (R2 = 0.88) in HG mice [27] and as noted above this region contains the Feml2 QTL [24].
T11613 16693-16697 DT denotes This
T11615 16698-16701 VBD denotes was
T11614 16702-16710 VBN denotes expected
T11616 16711-16716 IN denotes since
T11618 16717-16719 NN denotes NA
T11619 16720-16723 VBD denotes was
T11620 16724-16734 RB denotes previously
T11617 16735-16740 VBN denotes found
T11621 16741-16743 TO denotes to
T11622 16744-16746 VB denotes be
T11623 16747-16749 DT denotes an
T11625 16750-16759 JJ denotes excellent
T11624 16760-16769 NN denotes indicator
T11626 16770-16772 IN denotes of
T11627 16773-16778 NN denotes femur
T11628 16779-16785 NN denotes length
T11629 16786-16787 -LRB- denotes (
T11631 16787-16789 NN denotes R2
T11632 16790-16791 SYM denotes =
T11630 16792-16796 CD denotes 0.88
T11633 16796-16797 -RRB- denotes )
T11634 16798-16800 IN denotes in
T11635 16801-16803 NN denotes HG
T11636 16804-16808 NNS denotes mice
T11637 16809-16810 -LRB- denotes [
T11638 16810-16812 CD denotes 27
T11639 16812-16813 -RRB- denotes ]
T11640 16814-16817 CC denotes and
T11641 16818-16820 IN denotes as
T11642 16821-16826 VBN denotes noted
T11644 16827-16832 RB denotes above
T11645 16833-16837 DT denotes this
T11646 16838-16844 NN denotes region
T11643 16845-16853 VBZ denotes contains
T11647 16854-16857 DT denotes the
T11649 16858-16863 NN denotes Feml2
T11648 16864-16867 NN denotes QTL
T11650 16868-16869 -LRB- denotes [
T11651 16869-16871 CD denotes 24
T11652 16871-16872 -RRB- denotes ]
T11653 16872-16873 . denotes .
T11654 16873-17040 sentence denotes These data confirm the effects of Carfhg2 on adiposity and Feml2 on length and indicate the isolated effects of Carfhg2 are more significant than originally observed.
T11655 16874-16879 DT denotes These
T11656 16880-16884 NNS denotes data
T11657 16885-16892 VBP denotes confirm
T11658 16893-16896 DT denotes the
T11659 16897-16904 NNS denotes effects
T11660 16905-16907 IN denotes of
T11661 16908-16915 NN denotes Carfhg2
T11662 16916-16918 IN denotes on
T11663 16919-16928 NN denotes adiposity
T11664 16929-16932 CC denotes and
T11665 16933-16938 NN denotes Feml2
T11666 16939-16941 IN denotes on
T11667 16942-16948 NN denotes length
T11668 16949-16952 CC denotes and
T11669 16953-16961 VBP denotes indicate
T11670 16962-16965 DT denotes the
T11672 16966-16974 VBN denotes isolated
T11671 16975-16982 NNS denotes effects
T11674 16983-16985 IN denotes of
T11675 16986-16993 NN denotes Carfhg2
T11673 16994-16997 VBP denotes are
T11676 16998-17002 RBR denotes more
T11677 17003-17014 JJ denotes significant
T11678 17015-17019 IN denotes than
T11680 17020-17030 RB denotes originally
T11679 17031-17039 VBN denotes observed
T11681 17039-17040 . denotes .
T11682 17040-17046 sentence denotes HG11
T11683 17042-17046 NN denotes HG11
T11684 17046-17194 sentence denotes In the original intercross CAST alleles near 50 cM on MMU11 were linked with a reduction in G29, carcass ash (ASH) and carcass protein (PROT) [24].
T11685 17047-17049 IN denotes In
T11687 17050-17053 DT denotes the
T11689 17054-17062 JJ denotes original
T11688 17063-17073 NN denotes intercross
T11690 17074-17078 NN denotes CAST
T11691 17079-17086 NNS denotes alleles
T11692 17087-17091 IN denotes near
T11693 17092-17094 CD denotes 50
T11694 17095-17097 NN denotes cM
T11695 17098-17100 IN denotes on
T11696 17101-17106 NN denotes MMU11
T11697 17107-17111 VBD denotes were
T11686 17112-17118 VBN denotes linked
T11698 17119-17123 IN denotes with
T11699 17124-17125 DT denotes a
T11700 17126-17135 NN denotes reduction
T11701 17136-17138 IN denotes in
T11702 17139-17142 NN denotes G29
T11703 17142-17144 , denotes ,
T11704 17144-17151 NN denotes carcass
T11705 17152-17155 NN denotes ash
T11706 17156-17157 -LRB- denotes (
T11707 17157-17160 NN denotes ASH
T11708 17160-17161 -RRB- denotes )
T11709 17162-17165 CC denotes and
T11710 17166-17173 NN denotes carcass
T11711 17174-17181 NN denotes protein
T11712 17182-17183 -LRB- denotes (
T11713 17183-17187 NN denotes PROT
T11714 17187-17188 -RRB- denotes )
T11715 17189-17190 -LRB- denotes [
T11716 17190-17192 CD denotes 24
T11717 17192-17193 -RRB- denotes ]
T11718 17193-17194 . denotes .
T11719 17194-17313 sentence denotes Therefore, we measured each carcass component using chemical compositional analysis in the HGC, HG11 and HG17 strains.
T11720 17195-17204 RB denotes Therefore
T11722 17204-17206 , denotes ,
T11723 17206-17208 PRP denotes we
T11721 17209-17217 VBD denotes measured
T11724 17218-17222 DT denotes each
T11726 17223-17230 NN denotes carcass
T11725 17231-17240 NN denotes component
T11727 17241-17246 VBG denotes using
T11728 17247-17255 JJ denotes chemical
T11730 17256-17269 JJ denotes compositional
T11729 17270-17278 NN denotes analysis
T11731 17279-17281 IN denotes in
T11732 17282-17285 DT denotes the
T11734 17286-17289 NN denotes HGC
T11735 17289-17291 , denotes ,
T11736 17291-17295 NN denotes HG11
T11737 17296-17299 CC denotes and
T11738 17300-17304 NN denotes HG17
T11733 17305-17312 NNS denotes strains
T11739 17312-17313 . denotes .
T11740 17313-17418 sentence denotes Originally, Carp2 was dependent on the presence of hg and no significant sex effects were detected [24].
T11741 17314-17324 RB denotes Originally
T11743 17324-17326 , denotes ,
T11744 17326-17331 NN denotes Carp2
T11742 17332-17335 VBD denotes was
T11745 17336-17345 JJ denotes dependent
T11746 17346-17348 IN denotes on
T11747 17349-17352 DT denotes the
T11748 17353-17361 NN denotes presence
T11749 17362-17364 IN denotes of
T11750 17365-17367 NN denotes hg
T11751 17368-17371 CC denotes and
T11752 17372-17374 DT denotes no
T11754 17375-17386 JJ denotes significant
T11755 17387-17390 NN denotes sex
T11753 17391-17398 NNS denotes effects
T11757 17399-17403 VBD denotes were
T11756 17404-17412 VBN denotes detected
T11758 17413-17414 -LRB- denotes [
T11759 17414-17416 CD denotes 24
T11760 17416-17417 -RRB- denotes ]
T11761 17417-17418 . denotes .
T11762 17418-17533 sentence denotes In contrast to those results, HG11 mice displayed significant differences in growth and obesity between the sexes.
T11763 17419-17421 IN denotes In
T11765 17422-17430 NN denotes contrast
T11766 17431-17433 IN denotes to
T11767 17434-17439 DT denotes those
T11768 17440-17447 NNS denotes results
T11769 17447-17449 , denotes ,
T11770 17449-17453 NN denotes HG11
T11771 17454-17458 NNS denotes mice
T11764 17459-17468 VBD denotes displayed
T11772 17469-17480 JJ denotes significant
T11773 17481-17492 NNS denotes differences
T11774 17493-17495 IN denotes in
T11775 17496-17502 NN denotes growth
T11776 17503-17506 CC denotes and
T11777 17507-17514 NN denotes obesity
T11778 17515-17522 IN denotes between
T11779 17523-17526 DT denotes the
T11780 17527-17532 NNS denotes sexes
T11781 17532-17533 . denotes .
T11782 17533-17644 sentence denotes In general, males demonstrated a 5% increase and females a 5% decrease in all growth-related traits (Table 4).
T11783 17534-17536 IN denotes In
T11785 17537-17544 JJ denotes general
T11786 17544-17546 , denotes ,
T11787 17546-17551 NNS denotes males
T11784 17552-17564 VBD denotes demonstrated
T11788 17565-17566 DT denotes a
T11790 17567-17568 CD denotes 5
T11791 17568-17569 NN denotes %
T11789 17570-17578 NN denotes increase
T11792 17579-17582 CC denotes and
T11793 17583-17590 NNS denotes females
T11795 17591-17592 DT denotes a
T11796 17593-17594 CD denotes 5
T11797 17594-17595 NN denotes %
T11794 17596-17604 NN denotes decrease
T11798 17605-17607 IN denotes in
T11799 17608-17611 DT denotes all
T11801 17612-17618 NN denotes growth
T11803 17618-17619 HYPH denotes -
T11802 17619-17626 VBN denotes related
T11800 17627-17633 NNS denotes traits
T11804 17634-17635 -LRB- denotes (
T11805 17635-17640 NN denotes Table
T11806 17641-17642 CD denotes 4
T11807 17642-17643 -RRB- denotes )
T11808 17643-17644 . denotes .
T11809 17644-17774 sentence denotes Most of these differences, however, were not significant at a critical P < 0.005, although almost all were at a nominal P < 0.05.
T11810 17645-17649 JJS denotes Most
T11812 17650-17652 IN denotes of
T11813 17653-17658 DT denotes these
T11814 17659-17670 NNS denotes differences
T11815 17670-17672 , denotes ,
T11816 17672-17679 RB denotes however
T11817 17679-17681 , denotes ,
T11811 17681-17685 VBD denotes were
T11818 17686-17689 RB denotes not
T11819 17690-17701 JJ denotes significant
T11820 17702-17704 IN denotes at
T11821 17705-17706 DT denotes a
T11823 17707-17715 JJ denotes critical
T11824 17716-17717 NN denotes P
T11825 17718-17719 SYM denotes <
T11822 17720-17725 CD denotes 0.005
T11826 17725-17727 , denotes ,
T11827 17727-17735 IN denotes although
T11829 17736-17742 RB denotes almost
T11830 17743-17746 DT denotes all
T11828 17747-17751 VBD denotes were
T11831 17752-17754 IN denotes at
T11832 17755-17756 DT denotes a
T11834 17757-17764 JJ denotes nominal
T11835 17765-17766 NN denotes P
T11836 17767-17768 SYM denotes <
T11833 17769-17773 CD denotes 0.05
T11837 17773-17774 . denotes .
T11838 17774-17946 sentence denotes Following the same trend, males displayed an increase in tail length and a small suggestive increase in NA (P = 0.06), while females displayed significant decreases in NA.
T11839 17775-17784 VBG denotes Following
T11841 17785-17788 DT denotes the
T11843 17789-17793 JJ denotes same
T11842 17794-17799 NN denotes trend
T11844 17799-17801 , denotes ,
T11845 17801-17806 NNS denotes males
T11840 17807-17816 VBD denotes displayed
T11846 17817-17819 DT denotes an
T11847 17820-17828 NN denotes increase
T11848 17829-17831 IN denotes in
T11849 17832-17836 NN denotes tail
T11850 17837-17843 NN denotes length
T11851 17844-17847 CC denotes and
T11852 17848-17849 DT denotes a
T11854 17850-17855 JJ denotes small
T11855 17856-17866 JJ denotes suggestive
T11853 17867-17875 NN denotes increase
T11856 17876-17878 IN denotes in
T11857 17879-17881 NN denotes NA
T11858 17882-17883 -LRB- denotes (
T11860 17883-17884 NN denotes P
T11861 17885-17886 SYM denotes =
T11859 17887-17891 CD denotes 0.06
T11862 17891-17892 -RRB- denotes )
T11863 17892-17894 , denotes ,
T11864 17894-17899 IN denotes while
T11866 17900-17907 NNS denotes females
T11865 17908-17917 VBD denotes displayed
T11867 17918-17929 JJ denotes significant
T11868 17930-17939 NNS denotes decreases
T11869 17940-17942 IN denotes in
T11870 17943-17945 NN denotes NA
T11871 17945-17946 . denotes .
T11872 17946-18119 sentence denotes In support of the sex-specific QTL effects strain by sex interactions (P < 0.04) were seen for the following growth traits: 3WK, 6WK, 9WK, G26, G29 and NA (data not shown).
T11873 17947-17949 IN denotes In
T11875 17950-17957 NN denotes support
T11876 17958-17960 IN denotes of
T11877 17961-17964 DT denotes the
T11879 17965-17968 NN denotes sex
T11881 17968-17969 HYPH denotes -
T11880 17969-17977 JJ denotes specific
T11878 17978-17981 NN denotes QTL
T11882 17982-17989 NNS denotes effects
T11883 17990-17996 NN denotes strain
T11885 17997-17999 IN denotes by
T11886 18000-18003 NN denotes sex
T11884 18004-18016 NNS denotes interactions
T11887 18017-18018 -LRB- denotes (
T11889 18018-18019 NN denotes P
T11890 18020-18021 SYM denotes <
T11888 18022-18026 CD denotes 0.04
T11891 18026-18027 -RRB- denotes )
T11892 18028-18032 VBD denotes were
T11874 18033-18037 VBN denotes seen
T11893 18038-18041 IN denotes for
T11894 18042-18045 DT denotes the
T11896 18046-18055 JJ denotes following
T11897 18056-18062 NN denotes growth
T11895 18063-18069 NNS denotes traits
T11898 18069-18071 : denotes :
T11899 18071-18074 NN denotes 3WK
T11900 18074-18076 , denotes ,
T11901 18076-18079 NN denotes 6WK
T11902 18079-18081 , denotes ,
T11903 18081-18084 NN denotes 9WK
T11904 18084-18086 , denotes ,
T11905 18086-18089 NN denotes G26
T11906 18089-18091 , denotes ,
T11907 18091-18094 NN denotes G29
T11908 18095-18098 CC denotes and
T11909 18099-18101 NN denotes NA
T11910 18102-18103 -LRB- denotes (
T11912 18103-18107 NNS denotes data
T11913 18108-18111 RB denotes not
T11911 18112-18117 VBN denotes shown
T11914 18117-18118 -RRB- denotes )
T11915 18118-18119 . denotes .
T11916 18119-18205 sentence denotes The basis of each interaction was an increase in the males and a decrease in females.
T11917 18120-18123 DT denotes The
T11918 18124-18129 NN denotes basis
T11920 18130-18132 IN denotes of
T11921 18133-18137 DT denotes each
T11922 18138-18149 NN denotes interaction
T11919 18150-18153 VBD denotes was
T11923 18154-18156 DT denotes an
T11924 18157-18165 NN denotes increase
T11925 18166-18168 IN denotes in
T11926 18169-18172 DT denotes the
T11927 18173-18178 NNS denotes males
T11928 18179-18182 CC denotes and
T11929 18183-18184 DT denotes a
T11930 18185-18193 NN denotes decrease
T11931 18194-18196 IN denotes in
T11932 18197-18204 NNS denotes females
T11933 18204-18205 . denotes .
T11934 18205-18368 sentence denotes In our analysis of the HGC, HG11 and HG17 strains, concordant results were observed measuring adiposity using chemical lipid extraction and weighing fat pad mass.
T11935 18206-18208 IN denotes In
T11937 18209-18212 PRP$ denotes our
T11938 18213-18221 NN denotes analysis
T11939 18222-18224 IN denotes of
T11940 18225-18228 DT denotes the
T11942 18229-18232 NN denotes HGC
T11943 18232-18234 , denotes ,
T11944 18234-18238 NN denotes HG11
T11945 18239-18242 CC denotes and
T11946 18243-18247 NN denotes HG17
T11941 18248-18255 NNS denotes strains
T11947 18255-18257 , denotes ,
T11948 18257-18267 JJ denotes concordant
T11949 18268-18275 NNS denotes results
T11950 18276-18280 VBD denotes were
T11936 18281-18289 VBN denotes observed
T11951 18290-18299 VBG denotes measuring
T11952 18300-18309 NN denotes adiposity
T11953 18310-18315 VBG denotes using
T11954 18316-18324 JJ denotes chemical
T11956 18325-18330 NN denotes lipid
T11955 18331-18341 NN denotes extraction
T11957 18342-18345 CC denotes and
T11958 18346-18354 VBG denotes weighing
T11959 18355-18358 NN denotes fat
T11960 18359-18362 NN denotes pad
T11961 18363-18367 NN denotes mass
T11962 18367-18368 . denotes .
T11963 18368-18662 sentence denotes The phenotypic correlation between carcass fat (FAT) as a percent of the empty carcass weight (ECW; weight of total body (including organs) minus the head and gastrointestinal tract) (%FAT) determined by chemical analysis and AI, using data from all three lines (HGC, HG11 and HG17), was 0.92.
T11964 18369-18372 DT denotes The
T11966 18373-18383 JJ denotes phenotypic
T11965 18384-18395 NN denotes correlation
T11968 18396-18403 IN denotes between
T11969 18404-18411 NN denotes carcass
T11970 18412-18415 NN denotes fat
T11971 18416-18417 -LRB- denotes (
T11972 18417-18420 NN denotes FAT
T11973 18420-18421 -RRB- denotes )
T11974 18422-18424 IN denotes as
T11975 18425-18426 DT denotes a
T11976 18427-18434 NN denotes percent
T11977 18435-18437 IN denotes of
T11978 18438-18441 DT denotes the
T11980 18442-18447 JJ denotes empty
T11981 18448-18455 NN denotes carcass
T11979 18456-18462 NN denotes weight
T11982 18463-18464 -LRB- denotes (
T11983 18464-18467 NN denotes ECW
T11984 18467-18468 : denotes ;
T11985 18469-18475 NN denotes weight
T11986 18476-18478 IN denotes of
T11987 18479-18484 JJ denotes total
T11988 18485-18489 NN denotes body
T11989 18490-18491 -LRB- denotes (
T11990 18491-18500 VBG denotes including
T11991 18501-18507 NNS denotes organs
T11992 18507-18508 -RRB- denotes )
T11993 18509-18514 CC denotes minus
T11994 18515-18518 DT denotes the
T11995 18519-18523 NN denotes head
T11996 18524-18527 CC denotes and
T11997 18528-18544 JJ denotes gastrointestinal
T11998 18545-18550 NN denotes tract
T11999 18550-18551 -RRB- denotes )
T12000 18552-18553 -LRB- denotes (
T12001 18553-18554 NN denotes %
T12002 18554-18557 NN denotes FAT
T12003 18557-18558 -RRB- denotes )
T12004 18559-18569 VBN denotes determined
T12005 18570-18572 IN denotes by
T12006 18573-18581 JJ denotes chemical
T12007 18582-18590 NN denotes analysis
T12008 18591-18594 CC denotes and
T12009 18595-18597 NN denotes AI
T12010 18597-18599 , denotes ,
T12011 18599-18604 VBG denotes using
T12012 18605-18609 NNS denotes data
T12013 18610-18614 IN denotes from
T12014 18615-18618 DT denotes all
T12016 18619-18624 CD denotes three
T12015 18625-18630 NNS denotes lines
T12017 18631-18632 -LRB- denotes (
T12018 18632-18635 NN denotes HGC
T12019 18635-18637 , denotes ,
T12020 18637-18641 NN denotes HG11
T12021 18642-18645 CC denotes and
T12022 18646-18650 NN denotes HG17
T12023 18650-18651 -RRB- denotes )
T12024 18651-18653 , denotes ,
T11967 18653-18656 VBD denotes was
T12025 18657-18661 CD denotes 0.92
T12026 18661-18662 . denotes .
T12027 18662-18872 sentence denotes These data suggest that individual fat pad dissection is an excellent proxy for measuring whole body adiposity and provides a much more sensitive technique to measure fat accumulation in specific body regions.
T12028 18663-18668 DT denotes These
T12029 18669-18673 NNS denotes data
T12030 18674-18681 VBP denotes suggest
T12031 18682-18686 IN denotes that
T12033 18687-18697 JJ denotes individual
T12035 18698-18701 NN denotes fat
T12036 18702-18705 NN denotes pad
T12034 18706-18716 NN denotes dissection
T12032 18717-18719 VBZ denotes is
T12037 18720-18722 DT denotes an
T12039 18723-18732 JJ denotes excellent
T12038 18733-18738 NN denotes proxy
T12040 18739-18742 IN denotes for
T12041 18743-18752 VBG denotes measuring
T12042 18753-18758 JJ denotes whole
T12043 18759-18763 NN denotes body
T12044 18764-18773 NN denotes adiposity
T12045 18774-18777 CC denotes and
T12046 18778-18786 VBZ denotes provides
T12047 18787-18788 DT denotes a
T12049 18789-18793 RB denotes much
T12050 18794-18798 RBR denotes more
T12051 18799-18808 JJ denotes sensitive
T12048 18809-18818 NN denotes technique
T12052 18819-18821 TO denotes to
T12053 18822-18829 VB denotes measure
T12054 18830-18833 NN denotes fat
T12055 18834-18846 NN denotes accumulation
T12056 18847-18849 IN denotes in
T12057 18850-18858 JJ denotes specific
T12059 18859-18863 NN denotes body
T12058 18864-18871 NNS denotes regions
T12060 18871-18872 . denotes .
T12061 18872-19016 sentence denotes HG11 females displayed slight increases in all fat pads (except MFP) and AI, although, only the 16.5% increase in AI was significant (Table 5).
T12062 18873-18877 NN denotes HG11
T12063 18878-18885 NNS denotes females
T12064 18886-18895 VBD denotes displayed
T12065 18896-18902 JJ denotes slight
T12066 18903-18912 NNS denotes increases
T12067 18913-18915 IN denotes in
T12068 18916-18919 DT denotes all
T12070 18920-18923 NN denotes fat
T12069 18924-18928 NNS denotes pads
T12071 18929-18930 -LRB- denotes (
T12072 18930-18936 IN denotes except
T12073 18937-18940 NN denotes MFP
T12074 18940-18941 -RRB- denotes )
T12075 18942-18945 CC denotes and
T12076 18946-18948 NN denotes AI
T12077 18948-18950 , denotes ,
T12078 18950-18958 IN denotes although
T12080 18958-18960 , denotes ,
T12081 18960-18964 RB denotes only
T12083 18965-18968 DT denotes the
T12084 18969-18973 CD denotes 16.5
T12085 18973-18974 NN denotes %
T12082 18975-18983 NN denotes increase
T12086 18984-18986 IN denotes in
T12087 18987-18989 NN denotes AI
T12079 18990-18993 VBD denotes was
T12088 18994-19005 JJ denotes significant
T12089 19006-19007 -LRB- denotes (
T12090 19007-19012 NN denotes Table
T12091 19013-19014 CD denotes 5
T12092 19014-19015 -RRB- denotes )
T12093 19015-19016 . denotes .
T12094 19016-19166 sentence denotes In contrast, HG11 males did not show a difference in fat mass leading to a significant strain by sex interaction (P = 0.008) for AI (data not shown).
T12095 19017-19019 IN denotes In
T12097 19020-19028 NN denotes contrast
T12098 19028-19030 , denotes ,
T12099 19030-19034 NN denotes HG11
T12100 19035-19040 NNS denotes males
T12101 19041-19044 VBD denotes did
T12102 19045-19048 RB denotes not
T12096 19049-19053 VB denotes show
T12103 19054-19055 DT denotes a
T12104 19056-19066 NN denotes difference
T12105 19067-19069 IN denotes in
T12106 19070-19073 NN denotes fat
T12107 19074-19078 NN denotes mass
T12108 19079-19086 VBG denotes leading
T12109 19087-19089 IN denotes to
T12110 19090-19091 DT denotes a
T12112 19092-19103 JJ denotes significant
T12113 19104-19110 NN denotes strain
T12114 19111-19113 IN denotes by
T12115 19114-19117 NN denotes sex
T12111 19118-19129 NN denotes interaction
T12116 19130-19131 -LRB- denotes (
T12118 19131-19132 NN denotes P
T12119 19133-19134 SYM denotes =
T12117 19135-19140 CD denotes 0.008
T12120 19140-19141 -RRB- denotes )
T12121 19142-19145 IN denotes for
T12122 19146-19148 NN denotes AI
T12123 19149-19150 -LRB- denotes (
T12125 19150-19154 NNS denotes data
T12126 19155-19158 RB denotes not
T12124 19159-19164 VBN denotes shown
T12127 19164-19165 -RRB- denotes )
T12128 19165-19166 . denotes .
T12129 19166-19286 sentence denotes Identical to the results obtained using fat pad weights; female HG11 carcasses displayed an increase in %FAT (Table 6).
T12130 19167-19176 JJ denotes Identical
T12132 19177-19179 IN denotes to
T12133 19180-19183 DT denotes the
T12134 19184-19191 NNS denotes results
T12135 19192-19200 VBN denotes obtained
T12136 19201-19206 VBG denotes using
T12137 19207-19210 NN denotes fat
T12138 19211-19214 NN denotes pad
T12139 19215-19222 NNS denotes weights
T12140 19222-19223 : denotes ;
T12141 19224-19230 JJ denotes female
T12143 19231-19235 NN denotes HG11
T12142 19236-19245 NNS denotes carcasses
T12131 19246-19255 VBD denotes displayed
T12144 19256-19258 DT denotes an
T12145 19259-19267 NN denotes increase
T12146 19268-19270 IN denotes in
T12147 19271-19272 NN denotes %
T12148 19272-19275 NN denotes FAT
T12149 19276-19277 -LRB- denotes (
T12150 19277-19282 NN denotes Table
T12151 19283-19284 CD denotes 6
T12152 19284-19285 -RRB- denotes )
T12153 19285-19286 . denotes .
T12154 19286-19439 sentence denotes HG11 male carcasses had higher levels carcass ash (ASH) as a percent of ECW (%ASH) and female carcasses displayed lower levels of H2O and ASH (Table 6).
T12155 19287-19291 NN denotes HG11
T12157 19292-19296 JJ denotes male
T12156 19297-19306 NNS denotes carcasses
T12158 19307-19310 VBD denotes had
T12159 19311-19317 JJR denotes higher
T12160 19318-19324 NNS denotes levels
T12161 19325-19332 NN denotes carcass
T12162 19333-19336 NN denotes ash
T12163 19337-19338 -LRB- denotes (
T12164 19338-19341 NN denotes ASH
T12165 19341-19342 -RRB- denotes )
T12166 19343-19345 IN denotes as
T12167 19346-19347 DT denotes a
T12168 19348-19355 NN denotes percent
T12169 19356-19358 IN denotes of
T12170 19359-19362 NN denotes ECW
T12171 19363-19364 -LRB- denotes (
T12172 19364-19365 NN denotes %
T12173 19365-19368 NN denotes ASH
T12174 19368-19369 -RRB- denotes )
T12175 19370-19373 CC denotes and
T12176 19374-19380 JJ denotes female
T12177 19381-19390 NNS denotes carcasses
T12178 19391-19400 VBD denotes displayed
T12179 19401-19406 JJR denotes lower
T12180 19407-19413 NNS denotes levels
T12181 19414-19416 IN denotes of
T12182 19417-19420 NN denotes H2O
T12183 19421-19424 CC denotes and
T12184 19425-19428 NN denotes ASH
T12185 19429-19430 -LRB- denotes (
T12186 19430-19435 NN denotes Table
T12187 19436-19437 CD denotes 6
T12188 19437-19438 -RRB- denotes )
T12189 19438-19439 . denotes .
T12190 19439-19547 sentence denotes Strains by sex interactions (P < 0.005) were identified for H2O, %H2O, %FAT, ASH and PROT (data not shown).
T12191 19440-19447 NNS denotes Strains
T12193 19448-19450 IN denotes by
T12194 19451-19454 NN denotes sex
T12192 19455-19467 NNS denotes interactions
T12196 19468-19469 -LRB- denotes (
T12198 19469-19470 NN denotes P
T12199 19471-19472 SYM denotes <
T12197 19473-19478 CD denotes 0.005
T12200 19478-19479 -RRB- denotes )
T12201 19480-19484 VBD denotes were
T12195 19485-19495 VBN denotes identified
T12202 19496-19499 IN denotes for
T12203 19500-19503 NN denotes H2O
T12204 19503-19505 , denotes ,
T12205 19505-19506 NN denotes %
T12206 19506-19509 NN denotes H2O
T12207 19509-19511 , denotes ,
T12208 19511-19512 NN denotes %
T12209 19512-19515 NN denotes FAT
T12210 19515-19517 , denotes ,
T12211 19517-19520 NN denotes ASH
T12212 19521-19524 CC denotes and
T12213 19525-19529 NN denotes PROT
T12214 19530-19531 -LRB- denotes (
T12216 19531-19535 NNS denotes data
T12217 19536-19539 RB denotes not
T12215 19540-19545 VBN denotes shown
T12218 19545-19546 -RRB- denotes )
T12219 19546-19547 . denotes .
T12220 19547-19792 sentence denotes If the aggregate phenotype in HG11 is due to a single locus, its function may be to disrupt energy partitioning by decreasing the deposition of lean tissue and increasing lipid accumulation in females, while having the opposite action in males.
T12221 19548-19550 IN denotes If
T12223 19551-19554 DT denotes the
T12225 19555-19564 JJ denotes aggregate
T12224 19565-19574 NN denotes phenotype
T12226 19575-19577 IN denotes in
T12227 19578-19582 NN denotes HG11
T12222 19583-19585 VBZ denotes is
T12229 19586-19589 IN denotes due
T12230 19590-19592 IN denotes to
T12231 19593-19594 DT denotes a
T12233 19595-19601 JJ denotes single
T12232 19602-19607 NN denotes locus
T12234 19607-19609 , denotes ,
T12235 19609-19612 PRP$ denotes its
T12236 19613-19621 NN denotes function
T12237 19622-19625 MD denotes may
T12228 19626-19628 VB denotes be
T12238 19629-19631 TO denotes to
T12239 19632-19639 VB denotes disrupt
T12240 19640-19646 NN denotes energy
T12241 19647-19659 NN denotes partitioning
T12242 19660-19662 IN denotes by
T12243 19663-19673 VBG denotes decreasing
T12244 19674-19677 DT denotes the
T12245 19678-19688 NN denotes deposition
T12246 19689-19691 IN denotes of
T12247 19692-19696 JJ denotes lean
T12248 19697-19703 NN denotes tissue
T12249 19704-19707 CC denotes and
T12250 19708-19718 VBG denotes increasing
T12251 19719-19724 NN denotes lipid
T12252 19725-19737 NN denotes accumulation
T12253 19738-19740 IN denotes in
T12254 19741-19748 NNS denotes females
T12255 19748-19750 , denotes ,
T12256 19750-19755 IN denotes while
T12257 19756-19762 VBG denotes having
T12258 19763-19766 DT denotes the
T12260 19767-19775 JJ denotes opposite
T12259 19776-19782 NN denotes action
T12261 19783-19785 IN denotes in
T12262 19786-19791 NNS denotes males
T12263 19791-19792 . denotes .
T12264 19792-19871 sentence denotes However, it may also be due to distinct sex-specific QTL with opposing action.
T12265 19793-19800 RB denotes However
T12267 19800-19802 , denotes ,
T12268 19802-19804 PRP denotes it
T12269 19805-19808 MD denotes may
T12270 19809-19813 RB denotes also
T12266 19814-19816 VB denotes be
T12271 19817-19820 IN denotes due
T12272 19821-19823 IN denotes to
T12273 19824-19832 JJ denotes distinct
T12275 19833-19836 NN denotes sex
T12277 19836-19837 HYPH denotes -
T12276 19837-19845 JJ denotes specific
T12274 19846-19849 NN denotes QTL
T12278 19850-19854 IN denotes with
T12279 19855-19863 VBG denotes opposing
T12280 19864-19870 NN denotes action
T12281 19870-19871 . denotes .
T12282 19871-19877 sentence denotes HG17
T12283 19873-19877 NN denotes HG17
T12284 19877-20044 sentence denotes In the original intercross CAST alleles at MMU17 markers were associated with decreases in femur length, ASH and PROT [24] and similar results were seen in HG17 mice.
T12285 19878-19880 IN denotes In
T12287 19881-19884 DT denotes the
T12289 19885-19893 JJ denotes original
T12288 19894-19904 NN denotes intercross
T12290 19905-19909 NN denotes CAST
T12291 19910-19917 NNS denotes alleles
T12292 19918-19920 IN denotes at
T12293 19921-19926 NN denotes MMU17
T12294 19927-19934 NNS denotes markers
T12295 19935-19939 VBD denotes were
T12286 19940-19950 VBN denotes associated
T12296 19951-19955 IN denotes with
T12297 19956-19965 NNS denotes decreases
T12298 19966-19968 IN denotes in
T12299 19969-19974 NN denotes femur
T12300 19975-19981 NN denotes length
T12301 19981-19983 , denotes ,
T12302 19983-19986 NN denotes ASH
T12303 19987-19990 CC denotes and
T12304 19991-19995 NN denotes PROT
T12305 19996-19997 -LRB- denotes [
T12306 19997-19999 CD denotes 24
T12307 19999-20000 -RRB- denotes ]
T12308 20001-20004 CC denotes and
T12309 20005-20012 JJ denotes similar
T12310 20013-20020 NNS denotes results
T12312 20021-20025 VBD denotes were
T12311 20026-20030 VBN denotes seen
T12313 20031-20033 IN denotes in
T12314 20034-20038 NN denotes HG17
T12315 20039-20043 NNS denotes mice
T12316 20043-20044 . denotes .
T12317 20044-20206 sentence denotes Interestingly, both sexes were heavier at 2WK (males, P = 0.0045; females, P = 0.0342), but lighter at 9WK, leading to substantially lower G26 and G29 (Table 4).
T12318 20045-20058 RB denotes Interestingly
T12320 20058-20060 , denotes ,
T12321 20060-20064 DT denotes both
T12322 20065-20070 NNS denotes sexes
T12319 20071-20075 VBD denotes were
T12323 20076-20083 JJR denotes heavier
T12324 20084-20086 IN denotes at
T12325 20087-20090 NN denotes 2WK
T12326 20091-20092 -LRB- denotes (
T12328 20092-20097 NNS denotes males
T12330 20097-20099 , denotes ,
T12331 20099-20100 NN denotes P
T12332 20101-20102 SYM denotes =
T12329 20103-20109 CD denotes 0.0045
T12333 20109-20110 : denotes ;
T12334 20111-20118 NNS denotes females
T12335 20118-20120 , denotes ,
T12336 20120-20121 NN denotes P
T12337 20122-20123 SYM denotes =
T12327 20124-20130 CD denotes 0.0342
T12338 20130-20131 -RRB- denotes )
T12339 20131-20133 , denotes ,
T12340 20133-20136 CC denotes but
T12341 20137-20144 JJR denotes lighter
T12342 20145-20147 IN denotes at
T12343 20148-20151 NN denotes 9WK
T12344 20151-20153 , denotes ,
T12345 20153-20160 VBG denotes leading
T12346 20161-20163 IN denotes to
T12347 20164-20177 RB denotes substantially
T12348 20178-20183 JJR denotes lower
T12349 20184-20187 NN denotes G26
T12350 20188-20191 CC denotes and
T12351 20192-20195 NN denotes G29
T12352 20196-20197 -LRB- denotes (
T12353 20197-20202 NN denotes Table
T12354 20203-20204 CD denotes 4
T12355 20204-20205 -RRB- denotes )
T12356 20205-20206 . denotes .
T12357 20206-20286 sentence denotes In general growth differences ranged between 5% and 15% lower in congenic mice.
T12358 20207-20209 IN denotes In
T12360 20210-20217 JJ denotes general
T12361 20218-20224 NN denotes growth
T12362 20225-20236 NNS denotes differences
T12359 20237-20243 VBD denotes ranged
T12363 20244-20251 IN denotes between
T12364 20252-20253 CD denotes 5
T12365 20253-20254 NN denotes %
T12366 20255-20258 CC denotes and
T12367 20259-20261 CD denotes 15
T12368 20261-20262 NN denotes %
T12369 20263-20268 JJR denotes lower
T12370 20269-20271 IN denotes in
T12371 20272-20280 JJ denotes congenic
T12372 20281-20285 NNS denotes mice
T12373 20285-20286 . denotes .
T12374 20286-20367 sentence denotes Both sexes had significant reductions in length traits relative to control mice.
T12375 20287-20291 DT denotes Both
T12376 20292-20297 NNS denotes sexes
T12377 20298-20301 VBD denotes had
T12378 20302-20313 JJ denotes significant
T12379 20314-20324 NNS denotes reductions
T12380 20325-20327 IN denotes in
T12381 20328-20334 NN denotes length
T12382 20335-20341 NNS denotes traits
T12383 20342-20350 JJ denotes relative
T12384 20351-20353 IN denotes to
T12385 20354-20361 NN denotes control
T12386 20362-20366 NNS denotes mice
T12387 20366-20367 . denotes .
T12388 20367-20458 sentence denotes NA was reduced by 2.7% (P = 0.0186) and 3.4% in males and females, respectively (Table 4).
T12389 20368-20370 NN denotes NA
T12391 20371-20374 VBD denotes was
T12390 20375-20382 VBN denotes reduced
T12392 20383-20385 IN denotes by
T12393 20386-20389 CD denotes 2.7
T12394 20389-20390 NN denotes %
T12395 20391-20392 -LRB- denotes (
T12397 20392-20393 NN denotes P
T12398 20394-20395 SYM denotes =
T12396 20396-20402 CD denotes 0.0186
T12399 20402-20403 -RRB- denotes )
T12400 20404-20407 CC denotes and
T12401 20408-20411 CD denotes 3.4
T12402 20411-20412 NN denotes %
T12403 20413-20415 IN denotes in
T12404 20416-20421 NNS denotes males
T12405 20422-20425 CC denotes and
T12406 20426-20433 NNS denotes females
T12407 20433-20435 , denotes ,
T12408 20435-20447 RB denotes respectively
T12409 20448-20449 -LRB- denotes (
T12410 20449-20454 NN denotes Table
T12411 20455-20456 CD denotes 4
T12412 20456-20457 -RRB- denotes )
T12413 20457-20458 . denotes .
T12414 20458-20533 sentence denotes In addition, tail was reduced by approximately 6% in both sexes (Table 4).
T12415 20459-20461 IN denotes In
T12417 20462-20470 NN denotes addition
T12418 20470-20472 , denotes ,
T12419 20472-20476 NN denotes tail
T12420 20477-20480 VBD denotes was
T12416 20481-20488 VBN denotes reduced
T12421 20489-20491 IN denotes by
T12422 20492-20505 RB denotes approximately
T12423 20506-20507 CD denotes 6
T12424 20507-20508 NN denotes %
T12425 20509-20511 IN denotes in
T12426 20512-20516 DT denotes both
T12427 20517-20522 NNS denotes sexes
T12428 20523-20524 -LRB- denotes (
T12429 20524-20529 NN denotes Table
T12430 20530-20531 CD denotes 4
T12431 20531-20532 -RRB- denotes )
T12432 20532-20533 . denotes .
T12433 20533-20626 sentence denotes In general, HG17 mice displayed increases in all fat pads (except MFP), TF and AI (Table 5).
T12434 20534-20536 IN denotes In
T12436 20537-20544 JJ denotes general
T12437 20544-20546 , denotes ,
T12438 20546-20550 NN denotes HG17
T12439 20551-20555 NNS denotes mice
T12435 20556-20565 VBD denotes displayed
T12440 20566-20575 NNS denotes increases
T12441 20576-20578 IN denotes in
T12442 20579-20582 DT denotes all
T12444 20583-20586 NN denotes fat
T12443 20587-20591 NNS denotes pads
T12445 20592-20593 -LRB- denotes (
T12446 20593-20599 IN denotes except
T12447 20600-20603 NN denotes MFP
T12448 20603-20604 -RRB- denotes )
T12449 20604-20606 , denotes ,
T12450 20606-20608 NN denotes TF
T12451 20609-20612 CC denotes and
T12452 20613-20615 NN denotes AI
T12453 20616-20617 -LRB- denotes (
T12454 20617-20622 NN denotes Table
T12455 20623-20624 CD denotes 5
T12456 20624-20625 -RRB- denotes )
T12457 20625-20626 . denotes .
T12458 20626-20701 sentence denotes However, none of these differences were significant at critical P < 0.005.
T12459 20627-20634 RB denotes However
T12461 20634-20636 , denotes ,
T12462 20636-20640 NN denotes none
T12463 20641-20643 IN denotes of
T12464 20644-20649 DT denotes these
T12465 20650-20661 NNS denotes differences
T12460 20662-20666 VBD denotes were
T12466 20667-20678 JJ denotes significant
T12467 20679-20681 IN denotes at
T12468 20682-20690 JJ denotes critical
T12470 20691-20692 NN denotes P
T12471 20693-20694 SYM denotes <
T12469 20695-20700 CD denotes 0.005
T12472 20700-20701 . denotes .
T12473 20701-20860 sentence denotes In addition, HG17 male carcasses possessed lower levels of H2O and ASH, while female carcasses contained lower levels of % H2O, ASH, %ASH and %PROT (Table 6).
T12474 20702-20704 IN denotes In
T12476 20705-20713 NN denotes addition
T12477 20713-20715 , denotes ,
T12478 20715-20719 NN denotes HG17
T12480 20720-20724 JJ denotes male
T12479 20725-20734 NNS denotes carcasses
T12475 20735-20744 VBD denotes possessed
T12481 20745-20750 JJR denotes lower
T12482 20751-20757 NNS denotes levels
T12483 20758-20760 IN denotes of
T12484 20761-20764 NN denotes H2O
T12485 20765-20768 CC denotes and
T12486 20769-20772 NN denotes ASH
T12487 20772-20774 , denotes ,
T12488 20774-20779 IN denotes while
T12490 20780-20786 JJ denotes female
T12491 20787-20796 NNS denotes carcasses
T12489 20797-20806 VBD denotes contained
T12492 20807-20812 JJR denotes lower
T12493 20813-20819 NNS denotes levels
T12494 20820-20822 IN denotes of
T12495 20823-20824 NN denotes %
T12496 20825-20828 NN denotes H2O
T12497 20828-20830 , denotes ,
T12498 20830-20833 NN denotes ASH
T12499 20833-20835 , denotes ,
T12500 20835-20836 NN denotes %
T12501 20836-20839 NN denotes ASH
T12502 20840-20843 CC denotes and
T12503 20844-20845 NN denotes %
T12504 20845-20849 NN denotes PROT
T12505 20850-20851 -LRB- denotes (
T12506 20851-20856 NN denotes Table
T12507 20857-20858 CD denotes 6
T12508 20858-20859 -RRB- denotes )
T12509 20859-20860 . denotes .
T13271 20862-20865 NN denotes MMU
T13272 20865-20866 CD denotes 2
T13274 20866-20868 , denotes ,
T13275 20868-20869 CD denotes 9
T13276 20869-20871 , denotes ,
T13277 20871-20873 CD denotes 11
T13278 20874-20877 CC denotes and
T13279 20878-20880 CD denotes 17
T13280 20881-20883 NN denotes hg
T13281 20884-20892 NN denotes modifier
T13282 20893-20902 NN denotes candidate
T13283 20903-20907 NN denotes gene
T13273 20908-20918 NN denotes sequencing
T13284 20918-21132 sentence denotes The HG phenotype is due to the deletion of Socs2, therefore we reasoned that QTL on MMU2, 9, 11 and 17 interacting with hg possibly represent variation within genes participating in various aspects of Gh function.
T13285 20919-20922 DT denotes The
T13287 20923-20925 NN denotes HG
T13286 20926-20935 NN denotes phenotype
T13288 20936-20938 VBZ denotes is
T13290 20939-20942 IN denotes due
T13291 20943-20945 IN denotes to
T13292 20946-20949 DT denotes the
T13293 20950-20958 NN denotes deletion
T13294 20959-20961 IN denotes of
T13295 20962-20967 NN denotes Socs2
T13296 20967-20969 , denotes ,
T13297 20969-20978 RB denotes therefore
T13298 20979-20981 PRP denotes we
T13289 20982-20990 VBD denotes reasoned
T13299 20991-20995 IN denotes that
T13301 20996-20999 NN denotes QTL
T13302 21000-21002 IN denotes on
T13303 21003-21006 NN denotes MMU
T13304 21006-21007 CD denotes 2
T13305 21007-21009 , denotes ,
T13306 21009-21010 CD denotes 9
T13307 21010-21012 , denotes ,
T13308 21012-21014 CD denotes 11
T13309 21015-21018 CC denotes and
T13310 21019-21021 CD denotes 17
T13311 21022-21033 VBG denotes interacting
T13312 21034-21038 IN denotes with
T13313 21039-21041 NN denotes hg
T13314 21042-21050 RB denotes possibly
T13300 21051-21060 VBP denotes represent
T13315 21061-21070 NN denotes variation
T13316 21071-21077 IN denotes within
T13317 21078-21083 NNS denotes genes
T13318 21084-21097 VBG denotes participating
T13319 21098-21100 IN denotes in
T13320 21101-21108 JJ denotes various
T13321 21109-21116 NNS denotes aspects
T13322 21117-21119 IN denotes of
T13323 21120-21122 NN denotes Gh
T13324 21123-21131 NN denotes function
T13325 21131-21132 . denotes .
T13326 21132-21310 sentence denotes To select candidate genes for sequencing we identified genes known to be or potentially involved in Gh signaling, are responsive to Gh or that propagate downstream Gh functions.
T13327 21133-21135 TO denotes To
T13328 21136-21142 VB denotes select
T13330 21143-21152 NN denotes candidate
T13331 21153-21158 NNS denotes genes
T13332 21159-21162 IN denotes for
T13333 21163-21173 NN denotes sequencing
T13334 21174-21176 PRP denotes we
T13329 21177-21187 VBD denotes identified
T13335 21188-21193 NNS denotes genes
T13336 21194-21199 VBN denotes known
T13337 21200-21202 TO denotes to
T13338 21203-21205 VB denotes be
T13339 21206-21208 CC denotes or
T13340 21209-21220 RB denotes potentially
T13341 21221-21229 VBN denotes involved
T13342 21230-21232 IN denotes in
T13343 21233-21235 NN denotes Gh
T13344 21236-21245 NN denotes signaling
T13345 21245-21247 , denotes ,
T13346 21247-21250 VBP denotes are
T13347 21251-21261 JJ denotes responsive
T13348 21262-21264 IN denotes to
T13349 21265-21267 NN denotes Gh
T13350 21268-21270 CC denotes or
T13351 21271-21275 WDT denotes that
T13352 21276-21285 VBP denotes propagate
T13353 21286-21296 JJ denotes downstream
T13355 21297-21299 NN denotes Gh
T13354 21300-21309 NNS denotes functions
T13356 21309-21310 . denotes .
T13357 21310-21523 sentence denotes Forty-four hg modifier candidate genes were identified from primary literature, reviews and book chapters and coordinated using the GenMAPP (Gene MicroArray Pathway Profiler) pathway building software (Figure 5).
T13358 21311-21316 CD denotes Forty
T13360 21316-21317 HYPH denotes -
T13359 21317-21321 CD denotes four
T13362 21322-21324 NN denotes hg
T13363 21325-21333 NN denotes modifier
T13364 21334-21343 NN denotes candidate
T13361 21344-21349 NNS denotes genes
T13366 21350-21354 VBD denotes were
T13365 21355-21365 VBN denotes identified
T13367 21366-21370 IN denotes from
T13368 21371-21378 JJ denotes primary
T13369 21379-21389 NN denotes literature
T13370 21389-21391 , denotes ,
T13371 21391-21398 NNS denotes reviews
T13372 21399-21402 CC denotes and
T13373 21403-21407 NN denotes book
T13374 21408-21416 NNS denotes chapters
T13375 21417-21420 CC denotes and
T13376 21421-21432 VBN denotes coordinated
T13377 21433-21438 VBG denotes using
T13378 21439-21442 DT denotes the
T13380 21443-21450 NNP denotes GenMAPP
T13381 21451-21452 -LRB- denotes (
T13382 21452-21456 NNP denotes Gene
T13383 21457-21467 NNP denotes MicroArray
T13385 21468-21475 NNP denotes Pathway
T13384 21476-21484 NNP denotes Profiler
T13386 21484-21485 -RRB- denotes )
T13387 21486-21493 NN denotes pathway
T13388 21494-21502 NN denotes building
T13379 21503-21511 NN denotes software
T13389 21512-21513 -LRB- denotes (
T13390 21513-21519 NN denotes Figure
T13391 21520-21521 CD denotes 5
T13392 21521-21522 -RRB- denotes )
T13393 21522-21523 . denotes .
T13394 21523-21687 sentence denotes The coding region of each gene was sequenced from the CAST strain and compared to the publicly available B6 sequence to identify polymorphisms (Additional File 4).
T13395 21524-21527 DT denotes The
T13397 21528-21534 NN denotes coding
T13396 21535-21541 NN denotes region
T13399 21542-21544 IN denotes of
T13400 21545-21549 DT denotes each
T13401 21550-21554 NN denotes gene
T13402 21555-21558 VBD denotes was
T13398 21559-21568 VBN denotes sequenced
T13403 21569-21573 IN denotes from
T13404 21574-21577 DT denotes the
T13406 21578-21582 NN denotes CAST
T13405 21583-21589 NN denotes strain
T13407 21590-21593 CC denotes and
T13408 21594-21602 VBN denotes compared
T13409 21603-21605 IN denotes to
T13410 21606-21609 DT denotes the
T13412 21610-21618 RB denotes publicly
T13413 21619-21628 JJ denotes available
T13414 21629-21631 NN denotes B6
T13411 21632-21640 NN denotes sequence
T13415 21641-21643 TO denotes to
T13416 21644-21652 VB denotes identify
T13417 21653-21666 NNS denotes polymorphisms
T13418 21667-21668 -LRB- denotes (
T13420 21668-21678 JJ denotes Additional
T13419 21679-21683 NN denotes File
T13421 21684-21685 CD denotes 4
T13422 21685-21686 -RRB- denotes )
T13423 21686-21687 . denotes .
T13424 21687-21825 sentence denotes A total of 94.492 kbp was sequenced (75.378 kbp CDS and 19.114 Kbp 5' and 3' untranslated region (UTR)), representing 25,083 amino acids.
T13425 21688-21689 DT denotes A
T13426 21690-21695 NN denotes total
T13428 21696-21698 IN denotes of
T13429 21699-21705 CD denotes 94.492
T13430 21706-21709 NN denotes kbp
T13431 21710-21713 VBD denotes was
T13427 21714-21723 VBN denotes sequenced
T13432 21724-21725 -LRB- denotes (
T13434 21725-21731 CD denotes 75.378
T13435 21732-21735 NN denotes kbp
T13433 21736-21739 NN denotes CDS
T13436 21740-21743 CC denotes and
T13437 21744-21750 CD denotes 19.114
T13438 21751-21754 NN denotes Kbp
T13440 21755-21756 CD denotes 5
T13441 21756-21757 SYM denotes '
T13442 21758-21761 CC denotes and
T13443 21762-21763 CD denotes 3
T13444 21763-21764 SYM denotes '
T13445 21765-21777 JJ denotes untranslated
T13439 21778-21784 NN denotes region
T13446 21785-21786 -LRB- denotes (
T13447 21786-21789 NN denotes UTR
T13448 21789-21790 -RRB- denotes )
T13449 21790-21791 -RRB- denotes )
T13450 21791-21793 , denotes ,
T13451 21793-21805 VBG denotes representing
T13452 21806-21812 CD denotes 25,083
T13454 21813-21818 NN denotes amino
T13453 21819-21824 NNS denotes acids
T13455 21824-21825 . denotes .
T13456 21825-22057 sentence denotes Comparison with the public B6 assembly (May 2004 University of California, Santa Cruz (UCSC [28]) mm5 genome assembly, National Center for Biotechnology Information (NCBI) Build 33) identified 307 polymorphisms between CAST and B6.
T13457 21826-21836 NN denotes Comparison
T13459 21837-21841 IN denotes with
T13460 21842-21845 DT denotes the
T13462 21846-21852 JJ denotes public
T13463 21853-21855 NN denotes B6
T13461 21856-21864 NN denotes assembly
T13464 21865-21866 -LRB- denotes (
T13466 21866-21869 NNP denotes May
T13468 21870-21874 CD denotes 2004
T13467 21875-21885 NNP denotes University
T13469 21886-21888 IN denotes of
T13470 21889-21899 NNP denotes California
T13471 21899-21901 , denotes ,
T13472 21901-21906 NNP denotes Santa
T13473 21907-21911 NNP denotes Cruz
T13474 21912-21913 -LRB- denotes (
T13476 21913-21917 NNP denotes UCSC
T13477 21918-21919 -LRB- denotes [
T13475 21919-21921 CD denotes 28
T13478 21921-21922 -RRB- denotes ]
T13479 21922-21923 -RRB- denotes )
T13480 21924-21927 NN denotes mm5
T13482 21928-21934 NN denotes genome
T13481 21935-21943 NN denotes assembly
T13483 21943-21945 , denotes ,
T13484 21945-21953 NNP denotes National
T13485 21954-21960 NNP denotes Center
T13486 21961-21964 IN denotes for
T13487 21965-21978 NNP denotes Biotechnology
T13488 21979-21990 NNP denotes Information
T13489 21991-21992 -LRB- denotes (
T13490 21992-21996 NNP denotes NCBI
T13491 21996-21997 -RRB- denotes )
T13465 21998-22003 NN denotes Build
T13492 22004-22006 CD denotes 33
T13493 22006-22007 -RRB- denotes )
T13458 22008-22018 VBN denotes identified
T13494 22019-22022 CD denotes 307
T13495 22023-22036 NNS denotes polymorphisms
T13496 22037-22044 IN denotes between
T13497 22045-22049 NN denotes CAST
T13498 22050-22053 CC denotes and
T13499 22054-22056 NN denotes B6
T13500 22056-22057 . denotes .
T13501 22057-22179 sentence denotes Of these, 295 were single nucleotide polymorphisms (SNP) and 12 were insertions or deletions in CAST (Additional File 4).
T13502 22058-22060 IN denotes Of
T13504 22061-22066 DT denotes these
T13505 22066-22068 , denotes ,
T13506 22068-22071 CD denotes 295
T13503 22072-22076 VBD denotes were
T13507 22077-22083 JJ denotes single
T13509 22084-22094 NN denotes nucleotide
T13508 22095-22108 NNS denotes polymorphisms
T13510 22109-22110 -LRB- denotes (
T13511 22110-22113 NN denotes SNP
T13512 22113-22114 -RRB- denotes )
T13513 22115-22118 CC denotes and
T13514 22119-22121 CD denotes 12
T13515 22122-22126 VBD denotes were
T13516 22127-22137 NNS denotes insertions
T13517 22138-22140 CC denotes or
T13518 22141-22150 NNS denotes deletions
T13519 22151-22153 IN denotes in
T13520 22154-22158 NN denotes CAST
T13521 22159-22160 -LRB- denotes (
T13523 22160-22170 JJ denotes Additional
T13522 22171-22175 NN denotes File
T13524 22176-22177 CD denotes 4
T13525 22177-22178 -RRB- denotes )
T13526 22178-22179 . denotes .
T13527 22179-22246 sentence denotes All 12 insertions or deletions were located within 5' and 3' UTRs.
T13528 22180-22183 PDT denotes All
T13530 22184-22186 CD denotes 12
T13529 22187-22197 NNS denotes insertions
T13532 22198-22200 CC denotes or
T13533 22201-22210 NNS denotes deletions
T13534 22211-22215 VBD denotes were
T13531 22216-22223 VBN denotes located
T13535 22224-22230 IN denotes within
T13536 22231-22232 CD denotes 5
T13538 22232-22233 SYM denotes '
T13539 22234-22237 CC denotes and
T13540 22238-22239 CD denotes 3
T13541 22239-22240 SYM denotes '
T13537 22241-22245 NNS denotes UTRs
T13542 22245-22246 . denotes .
T13543 22246-22341 sentence denotes Fifty-six nonsynonomous SNP (nsSNP) were identified in 14 different genes (Additional File 4).
T13544 22247-22252 CD denotes Fifty
T13546 22252-22253 HYPH denotes -
T13545 22253-22256 CD denotes six
T13548 22257-22270 JJ denotes nonsynonomous
T13547 22271-22274 NN denotes SNP
T13550 22275-22276 -LRB- denotes (
T13551 22276-22281 NN denotes nsSNP
T13552 22281-22282 -RRB- denotes )
T13553 22283-22287 VBD denotes were
T13549 22288-22298 VBN denotes identified
T13554 22299-22301 IN denotes in
T13555 22302-22304 CD denotes 14
T13557 22305-22314 JJ denotes different
T13556 22315-22320 NNS denotes genes
T13558 22321-22322 -LRB- denotes (
T13560 22322-22332 JJ denotes Additional
T13559 22333-22337 NN denotes File
T13561 22338-22339 CD denotes 4
T13562 22339-22340 -RRB- denotes )
T13563 22340-22341 . denotes .
T13564 22341-22613 sentence denotes PolyPhen [29] and SIFT [30] are software programs designed to identify nsSNP which potentially alter protein function by evaluating evolutionary conservation at specific amino acid residues using a multiple sequence alignment of protein sequences homologous to the query.
T13565 22342-22350 NNP denotes PolyPhen
T13567 22351-22352 -LRB- denotes [
T13568 22352-22354 CD denotes 29
T13569 22354-22355 -RRB- denotes ]
T13570 22356-22359 CC denotes and
T13571 22360-22364 NN denotes SIFT
T13572 22365-22366 -LRB- denotes [
T13573 22366-22368 CD denotes 30
T13574 22368-22369 -RRB- denotes ]
T13566 22370-22373 VBP denotes are
T13575 22374-22382 NN denotes software
T13576 22383-22391 NNS denotes programs
T13577 22392-22400 VBN denotes designed
T13578 22401-22403 TO denotes to
T13579 22404-22412 VB denotes identify
T13580 22413-22418 NN denotes nsSNP
T13581 22419-22424 WDT denotes which
T13583 22425-22436 RB denotes potentially
T13582 22437-22442 VBP denotes alter
T13584 22443-22450 NN denotes protein
T13585 22451-22459 NN denotes function
T13586 22460-22462 IN denotes by
T13587 22463-22473 VBG denotes evaluating
T13588 22474-22486 JJ denotes evolutionary
T13589 22487-22499 NN denotes conservation
T13590 22500-22502 IN denotes at
T13591 22503-22511 JJ denotes specific
T13593 22512-22517 NN denotes amino
T13594 22518-22522 NN denotes acid
T13592 22523-22531 NNS denotes residues
T13595 22532-22537 VBG denotes using
T13596 22538-22539 DT denotes a
T13598 22540-22548 JJ denotes multiple
T13599 22549-22557 NN denotes sequence
T13597 22558-22567 NN denotes alignment
T13600 22568-22570 IN denotes of
T13601 22571-22578 NN denotes protein
T13602 22579-22588 NNS denotes sequences
T13603 22589-22599 JJ denotes homologous
T13604 22600-22602 IN denotes to
T13605 22603-22606 DT denotes the
T13606 22607-22612 NN denotes query
T13607 22612-22613 . denotes .
T13608 22613-22778 sentence denotes When applied to our data set PolyPhen, SIFT or both programs predicted that 15 of the 56 nsSNP in 9 different genes would possibly alter protein function (Table 7).
T13609 22614-22618 WRB denotes When
T13610 22619-22626 VBN denotes applied
T13612 22627-22629 IN denotes to
T13613 22630-22633 PRP$ denotes our
T13615 22634-22638 NNS denotes data
T13614 22639-22642 NN denotes set
T13616 22643-22651 NNP denotes PolyPhen
T13617 22651-22653 , denotes ,
T13618 22653-22657 NNP denotes SIFT
T13619 22658-22660 CC denotes or
T13620 22661-22665 DT denotes both
T13621 22666-22674 NNS denotes programs
T13611 22675-22684 VBD denotes predicted
T13622 22685-22689 IN denotes that
T13624 22690-22692 CD denotes 15
T13626 22693-22695 IN denotes of
T13627 22696-22699 DT denotes the
T13625 22700-22702 CD denotes 56
T13628 22703-22708 NN denotes nsSNP
T13629 22709-22711 IN denotes in
T13630 22712-22713 CD denotes 9
T13632 22714-22723 JJ denotes different
T13631 22724-22729 NNS denotes genes
T13633 22730-22735 MD denotes would
T13634 22736-22744 RB denotes possibly
T13623 22745-22750 VB denotes alter
T13635 22751-22758 NN denotes protein
T13636 22759-22767 NN denotes function
T13637 22768-22769 -LRB- denotes (
T13638 22769-22774 NN denotes Table
T13639 22775-22776 CD denotes 7
T13640 22776-22777 -RRB- denotes )
T13641 22777-22778 . denotes .
T17718 22791-22796 NN denotes Speed
T17719 22797-22805 JJ denotes congenic
T17720 22806-22813 NNS denotes strains
T17721 22814-22821 VBP denotes provide
T17722 22822-22823 DT denotes a
T17724 22824-22832 JJ denotes powerful
T17723 22833-22841 NN denotes approach
T17725 22842-22844 TO denotes to
T17726 22845-22852 VB denotes confirm
T17727 22853-22856 CC denotes and
T17728 22857-22867 RB denotes physically
T17729 22868-22875 VB denotes confine
T17730 22876-22879 NN denotes QTL
T17731 22880-22886 IN denotes within
T17732 22887-22896 NNS denotes intervals
T17733 22897-22904 VBN denotes defined
T17734 22905-22907 IN denotes by
T17735 22908-22917 JJ denotes molecular
T17736 22918-22925 NNS denotes markers
T17737 22925-22926 . denotes .
T17738 22926-23147 sentence denotes In the current study, approximately 20% of the CAST genome harboring all previously detected growth and carcass composition QTL was isolated on an HG or B6 background through the development of 14 speed congenic strains.
T17739 22927-22929 IN denotes In
T17741 22930-22933 DT denotes the
T17743 22934-22941 JJ denotes current
T17742 22942-22947 NN denotes study
T17744 22947-22949 , denotes ,
T17745 22949-22962 RB denotes approximately
T17746 22963-22965 CD denotes 20
T17747 22965-22966 NN denotes %
T17748 22967-22969 IN denotes of
T17749 22970-22973 DT denotes the
T17751 22974-22978 NN denotes CAST
T17750 22979-22985 NN denotes genome
T17752 22986-22995 VBG denotes harboring
T17753 22996-22999 RB denotes all
T17755 23000-23010 RB denotes previously
T17756 23011-23019 VBN denotes detected
T17757 23020-23026 NN denotes growth
T17759 23027-23030 CC denotes and
T17760 23031-23038 NN denotes carcass
T17758 23039-23050 NN denotes composition
T17754 23051-23054 NN denotes QTL
T17761 23055-23058 VBD denotes was
T17740 23059-23067 VBN denotes isolated
T17762 23068-23070 IN denotes on
T17763 23071-23073 DT denotes an
T17765 23074-23076 NN denotes HG
T17766 23077-23079 CC denotes or
T17767 23080-23082 NN denotes B6
T17764 23083-23093 NN denotes background
T17768 23094-23101 IN denotes through
T17769 23102-23105 DT denotes the
T17770 23106-23117 NN denotes development
T17771 23118-23120 IN denotes of
T17772 23121-23123 CD denotes 14
T17774 23124-23129 NN denotes speed
T17775 23130-23138 JJ denotes congenic
T17773 23139-23146 NNS denotes strains
T17776 23146-23147 . denotes .
T17777 23147-23344 sentence denotes Two distinct speed congenic panels were developed, the first provided a comprehensive isolation of all MMU2 QTL between the B6, HG and CAST strains and the second targeted all QTL outside of MMU2.
T17778 23148-23151 CD denotes Two
T17780 23152-23160 JJ denotes distinct
T17781 23161-23166 NN denotes speed
T17782 23167-23175 JJ denotes congenic
T17779 23176-23182 NNS denotes panels
T17784 23183-23187 VBD denotes were
T17783 23188-23197 VBN denotes developed
T17786 23197-23199 , denotes ,
T17787 23199-23202 DT denotes the
T17788 23203-23208 JJ denotes first
T17785 23209-23217 VBD denotes provided
T17789 23218-23219 DT denotes a
T17791 23220-23233 JJ denotes comprehensive
T17790 23234-23243 NN denotes isolation
T17792 23244-23246 IN denotes of
T17793 23247-23250 DT denotes all
T17795 23251-23255 NN denotes MMU2
T17794 23256-23259 NN denotes QTL
T17796 23260-23267 IN denotes between
T17797 23268-23271 DT denotes the
T17799 23272-23274 NN denotes B6
T17800 23274-23276 , denotes ,
T17801 23276-23278 NN denotes HG
T17802 23279-23282 CC denotes and
T17803 23283-23287 NN denotes CAST
T17798 23288-23295 NNS denotes strains
T17804 23296-23299 CC denotes and
T17805 23300-23303 DT denotes the
T17806 23304-23310 NN denotes second
T17807 23311-23319 VBD denotes targeted
T17808 23320-23323 DT denotes all
T17809 23324-23327 NN denotes QTL
T17810 23328-23335 IN denotes outside
T17811 23336-23338 IN denotes of
T17812 23339-23343 NN denotes MMU2
T17813 23343-23344 . denotes .
T17814 23344-23442 sentence denotes Each successfully characterized strain exhibited phenotypic differences relative to control mice.
T17815 23345-23349 DT denotes Each
T17817 23350-23362 RB denotes successfully
T17818 23363-23376 VBN denotes characterized
T17816 23377-23383 NN denotes strain
T17819 23384-23393 VBD denotes exhibited
T17820 23394-23404 JJ denotes phenotypic
T17821 23405-23416 NNS denotes differences
T17822 23417-23425 JJ denotes relative
T17823 23426-23428 IN denotes to
T17824 23429-23436 NN denotes control
T17825 23437-23441 NNS denotes mice
T17826 23441-23442 . denotes .
T17827 23442-23576 sentence denotes These strains represent important resources and provide the genetic resource to positionally clone numerous quantitative trait genes.
T17828 23443-23448 DT denotes These
T17829 23449-23456 NNS denotes strains
T17830 23457-23466 VBP denotes represent
T17831 23467-23476 JJ denotes important
T17832 23477-23486 NNS denotes resources
T17833 23487-23490 CC denotes and
T17834 23491-23498 VB denotes provide
T17835 23499-23502 DT denotes the
T17837 23503-23510 JJ denotes genetic
T17836 23511-23519 NN denotes resource
T17838 23520-23522 TO denotes to
T17840 23523-23535 RB denotes positionally
T17839 23536-23541 VB denotes clone
T17841 23542-23550 JJ denotes numerous
T17843 23551-23563 JJ denotes quantitative
T17844 23564-23569 NN denotes trait
T17842 23570-23575 NNS denotes genes
T17845 23575-23576 . denotes .
T17846 23576-23721 sentence denotes One criticism of the speed congenic approach is the potential for QTL to reside among unwanted donor alleles not eliminated during backcrossing.
T17847 23577-23580 CD denotes One
T17848 23581-23590 NN denotes criticism
T17850 23591-23593 IN denotes of
T17851 23594-23597 DT denotes the
T17853 23598-23603 NN denotes speed
T17854 23604-23612 JJ denotes congenic
T17852 23613-23621 NN denotes approach
T17849 23622-23624 VBZ denotes is
T17855 23625-23628 DT denotes the
T17856 23629-23638 NN denotes potential
T17857 23639-23642 IN denotes for
T17859 23643-23646 NN denotes QTL
T17860 23647-23649 TO denotes to
T17858 23650-23656 VB denotes reside
T17861 23657-23662 IN denotes among
T17862 23663-23671 JJ denotes unwanted
T17864 23672-23677 NN denotes donor
T17863 23678-23685 NNS denotes alleles
T17865 23686-23689 RB denotes not
T17866 23690-23700 VBN denotes eliminated
T17867 23701-23707 IN denotes during
T17868 23708-23720 NN denotes backcrossing
T17869 23720-23721 . denotes .
T17870 23721-23849 sentence denotes In this case differences between the congenic and control strains would be due in part or whole to these contaminating alleles.
T17871 23722-23724 IN denotes In
T17873 23725-23729 DT denotes this
T17874 23730-23734 NN denotes case
T17875 23735-23746 NNS denotes differences
T17876 23747-23754 IN denotes between
T17877 23755-23758 DT denotes the
T17879 23759-23767 JJ denotes congenic
T17880 23768-23771 CC denotes and
T17881 23772-23779 NN denotes control
T17878 23780-23787 NNS denotes strains
T17882 23788-23793 MD denotes would
T17872 23794-23796 VB denotes be
T17883 23797-23800 IN denotes due
T17884 23801-23803 IN denotes in
T17885 23804-23808 NN denotes part
T17886 23809-23811 CC denotes or
T17887 23812-23817 NN denotes whole
T17888 23818-23820 IN denotes to
T17889 23821-23826 DT denotes these
T17891 23827-23840 VBG denotes contaminating
T17890 23841-23848 NNS denotes alleles
T17892 23848-23849 . denotes .
T17893 23849-23923 sentence denotes We took several precautions to reduce the probability of this occurrence.
T17894 23850-23852 PRP denotes We
T17895 23853-23857 VBD denotes took
T17896 23858-23865 JJ denotes several
T17897 23866-23877 NNS denotes precautions
T17898 23878-23880 TO denotes to
T17899 23881-23887 VB denotes reduce
T17900 23888-23891 DT denotes the
T17901 23892-23903 NN denotes probability
T17902 23904-23906 IN denotes of
T17903 23907-23911 DT denotes this
T17904 23912-23922 NN denotes occurrence
T17905 23922-23923 . denotes .
T17906 23923-24036 sentence denotes First, our control strains were developed from mice undergoing the same selection as all of the other congenics.
T17907 23924-23929 RB denotes First
T17909 23929-23931 , denotes ,
T17910 23931-23934 PRP$ denotes our
T17912 23935-23942 NN denotes control
T17911 23943-23950 NNS denotes strains
T17913 23951-23955 VBD denotes were
T17908 23956-23965 VBN denotes developed
T17914 23966-23970 IN denotes from
T17915 23971-23975 NNS denotes mice
T17916 23976-23986 VBG denotes undergoing
T17917 23987-23990 DT denotes the
T17919 23991-23995 JJ denotes same
T17918 23996-24005 NN denotes selection
T17920 24006-24008 IN denotes as
T17921 24009-24012 DT denotes all
T17922 24013-24015 IN denotes of
T17923 24016-24019 DT denotes the
T17925 24020-24025 JJ denotes other
T17924 24026-24035 NNS denotes congenics
T17926 24035-24036 . denotes .
T17927 24036-24166 sentence denotes Therefore, it is possible that any unwanted QTL or mutations arising during congenic construction are shared between all strains.
T17928 24037-24046 RB denotes Therefore
T17930 24046-24048 , denotes ,
T17931 24048-24050 PRP denotes it
T17929 24051-24053 VBZ denotes is
T17932 24054-24062 JJ denotes possible
T17933 24063-24067 IN denotes that
T17935 24068-24071 DT denotes any
T17937 24072-24080 JJ denotes unwanted
T17936 24081-24084 NN denotes QTL
T17938 24085-24087 CC denotes or
T17939 24088-24097 NNS denotes mutations
T17940 24098-24105 VBG denotes arising
T17941 24106-24112 IN denotes during
T17942 24113-24121 JJ denotes congenic
T17943 24122-24134 NN denotes construction
T17944 24135-24138 VBP denotes are
T17934 24139-24145 VBN denotes shared
T17945 24146-24153 IN denotes between
T17946 24154-24157 DT denotes all
T17947 24158-24165 NNS denotes strains
T17948 24165-24166 . denotes .
T17949 24166-24285 sentence denotes More importantly, we have knowledge of all large previously detected growth and obesity QTL in the current cross [24].
T17950 24167-24171 RBR denotes More
T17951 24172-24183 RB denotes importantly
T17953 24183-24185 , denotes ,
T17954 24185-24187 PRP denotes we
T17952 24188-24192 VBP denotes have
T17955 24193-24202 NN denotes knowledge
T17956 24203-24205 IN denotes of
T17957 24206-24209 DT denotes all
T17959 24210-24215 JJ denotes large
T17960 24216-24226 RB denotes previously
T17961 24227-24235 VBN denotes detected
T17962 24236-24242 NN denotes growth
T17963 24243-24246 CC denotes and
T17964 24247-24254 NN denotes obesity
T17958 24255-24258 NN denotes QTL
T17965 24259-24261 IN denotes in
T17966 24262-24265 DT denotes the
T17968 24266-24273 JJ denotes current
T17967 24274-24279 NN denotes cross
T17969 24280-24281 -LRB- denotes [
T17970 24281-24283 CD denotes 24
T17971 24283-24284 -RRB- denotes ]
T17972 24284-24285 . denotes .
T17973 24285-24484 sentence denotes Using this information we increased the density of markers in each QTL region (MMU1, 2, 5, 8, 9, 11 and 17; Table 1 and Additional File 1), ensuring the absence of CAST alleles at each of these QTL.
T17974 24286-24291 VBG denotes Using
T17976 24292-24296 DT denotes this
T17977 24297-24308 NN denotes information
T17978 24309-24311 PRP denotes we
T17975 24312-24321 VBD denotes increased
T17979 24322-24325 DT denotes the
T17980 24326-24333 NN denotes density
T17981 24334-24336 IN denotes of
T17982 24337-24344 NNS denotes markers
T17983 24345-24347 IN denotes in
T17984 24348-24352 DT denotes each
T17986 24353-24356 NN denotes QTL
T17985 24357-24363 NN denotes region
T17987 24364-24365 -LRB- denotes (
T17989 24365-24368 NN denotes MMU
T17990 24368-24369 CD denotes 1
T17991 24369-24371 , denotes ,
T17992 24371-24372 CD denotes 2
T17993 24372-24374 , denotes ,
T17994 24374-24375 CD denotes 5
T17995 24375-24377 , denotes ,
T17996 24377-24378 CD denotes 8
T17997 24378-24380 , denotes ,
T17998 24380-24381 CD denotes 9
T17999 24381-24383 , denotes ,
T18000 24383-24385 CD denotes 11
T18001 24386-24389 CC denotes and
T18002 24390-24392 CD denotes 17
T18003 24392-24393 : denotes ;
T17988 24394-24399 NN denotes Table
T18004 24400-24401 CD denotes 1
T18005 24402-24405 CC denotes and
T18006 24406-24416 JJ denotes Additional
T18007 24417-24421 NN denotes File
T18008 24422-24423 CD denotes 1
T18009 24423-24424 -RRB- denotes )
T18010 24424-24426 , denotes ,
T18011 24426-24434 VBG denotes ensuring
T18012 24435-24438 DT denotes the
T18013 24439-24446 NN denotes absence
T18014 24447-24449 IN denotes of
T18015 24450-24454 NN denotes CAST
T18016 24455-24462 NNS denotes alleles
T18017 24463-24465 IN denotes at
T18018 24466-24470 DT denotes each
T18019 24471-24473 IN denotes of
T18020 24474-24479 DT denotes these
T18021 24480-24483 NN denotes QTL
T18022 24483-24484 . denotes .
T18023 24484-24643 sentence denotes This approach, termed "QTL-Marker-Assisted Counter Selection" or QMACS, has been previously used to characterize QTL for hypnotic sensitivity to ethanol [31].
T18024 24485-24489 DT denotes This
T18025 24490-24498 NN denotes approach
T18027 24498-24500 , denotes ,
T18028 24500-24506 VBN denotes termed
T18029 24507-24508 `` denotes "
T18030 24508-24511 NN denotes QTL
T18032 24511-24512 HYPH denotes -
T18031 24512-24518 NN denotes Marker
T18034 24518-24519 HYPH denotes -
T18033 24519-24527 VBN denotes Assisted
T18036 24528-24535 NN denotes Counter
T18035 24536-24545 NN denotes Selection
T18037 24545-24546 '' denotes "
T18038 24547-24549 CC denotes or
T18039 24550-24555 NN denotes QMACS
T18040 24555-24557 , denotes ,
T18041 24557-24560 VBZ denotes has
T18042 24561-24565 VBN denotes been
T18043 24566-24576 RB denotes previously
T18026 24577-24581 VBN denotes used
T18044 24582-24584 TO denotes to
T18045 24585-24597 VB denotes characterize
T18046 24598-24601 NN denotes QTL
T18047 24602-24605 IN denotes for
T18048 24606-24614 JJ denotes hypnotic
T18049 24615-24626 NN denotes sensitivity
T18050 24627-24629 IN denotes to
T18051 24630-24637 NN denotes ethanol
T18052 24638-24639 -LRB- denotes [
T18053 24639-24641 CD denotes 31
T18054 24641-24642 -RRB- denotes ]
T18055 24642-24643 . denotes .
T18056 24643-24721 sentence denotes In that study, only markers flanking QTL were typed, not genome-wide markers.
T18057 24644-24646 IN denotes In
T18059 24647-24651 DT denotes that
T18060 24652-24657 NN denotes study
T18061 24657-24659 , denotes ,
T18062 24659-24663 RB denotes only
T18063 24664-24671 NNS denotes markers
T18064 24672-24680 VBG denotes flanking
T18065 24681-24684 NN denotes QTL
T18066 24685-24689 VBD denotes were
T18058 24690-24695 VBN denotes typed
T18067 24695-24697 , denotes ,
T18068 24697-24700 CC denotes not
T18070 24701-24707 NN denotes genome
T18072 24707-24708 HYPH denotes -
T18071 24708-24712 JJ denotes wide
T18069 24713-24720 NNS denotes markers
T18073 24720-24721 . denotes .
T18074 24721-24926 sentence denotes In contrast, we selected not only against known QTL, we also screened for genome wide heterozygosity increasing the probability that effects observed are due to genetic variation within each donor region.
T18075 24722-24724 IN denotes In
T18077 24725-24733 NN denotes contrast
T18078 24733-24735 , denotes ,
T18079 24735-24737 PRP denotes we
T18080 24738-24746 VBD denotes selected
T18081 24747-24750 RB denotes not
T18082 24751-24755 RB denotes only
T18083 24756-24763 IN denotes against
T18084 24764-24769 VBN denotes known
T18085 24770-24773 NN denotes QTL
T18086 24773-24775 , denotes ,
T18087 24775-24777 PRP denotes we
T18088 24778-24782 RB denotes also
T18076 24783-24791 VBD denotes screened
T18089 24792-24795 IN denotes for
T18090 24796-24802 NN denotes genome
T18091 24803-24807 JJ denotes wide
T18092 24808-24822 NN denotes heterozygosity
T18093 24823-24833 VBG denotes increasing
T18094 24834-24837 DT denotes the
T18095 24838-24849 NN denotes probability
T18096 24850-24854 IN denotes that
T18098 24855-24862 NNS denotes effects
T18099 24863-24871 VBN denotes observed
T18097 24872-24875 VBP denotes are
T18100 24876-24879 IN denotes due
T18101 24880-24882 IN denotes to
T18102 24883-24890 JJ denotes genetic
T18103 24891-24900 NN denotes variation
T18104 24901-24907 IN denotes within
T18105 24908-24912 DT denotes each
T18107 24913-24918 NN denotes donor
T18106 24919-24925 NN denotes region
T18108 24925-24926 . denotes .
T18109 24926-25177 sentence denotes Although great effort was put forth to eliminate non-donor region direct genetic effects, other factors such as maternal genotype (maternal genotype for each congenic versus control dams differed) and environmental effects could confound our results.
T18110 24927-24935 IN denotes Although
T18112 24936-24941 JJ denotes great
T18113 24942-24948 NN denotes effort
T18114 24949-24952 VBD denotes was
T18111 24953-24956 VBN denotes put
T18116 24957-24962 RP denotes forth
T18117 24963-24965 TO denotes to
T18118 24966-24975 VB denotes eliminate
T18119 24976-24985 JJ denotes non-donor
T18120 24986-24992 NN denotes region
T18122 24993-24999 JJ denotes direct
T18123 25000-25007 JJ denotes genetic
T18121 25008-25015 NNS denotes effects
T18124 25015-25017 , denotes ,
T18125 25017-25022 JJ denotes other
T18126 25023-25030 NNS denotes factors
T18127 25031-25035 JJ denotes such
T18128 25036-25038 IN denotes as
T18129 25039-25047 JJ denotes maternal
T18130 25048-25056 NN denotes genotype
T18131 25057-25058 -LRB- denotes (
T18133 25058-25066 JJ denotes maternal
T18134 25067-25075 NN denotes genotype
T18135 25076-25079 IN denotes for
T18136 25080-25084 DT denotes each
T18137 25085-25093 JJ denotes congenic
T18138 25094-25100 CC denotes versus
T18139 25101-25108 NN denotes control
T18140 25109-25113 NNS denotes dams
T18132 25114-25122 VBD denotes differed
T18141 25122-25123 -RRB- denotes )
T18142 25124-25127 CC denotes and
T18143 25128-25141 JJ denotes environmental
T18144 25142-25149 NNS denotes effects
T18145 25150-25155 MD denotes could
T18115 25156-25164 VB denotes confound
T18146 25165-25168 PRP$ denotes our
T18147 25169-25176 NNS denotes results
T18148 25176-25177 . denotes .
T18149 25177-25346 sentence denotes Maternal genotype effects on growth and obesity have been observed in a number of mouse crosses [8,32-35] and their existence in the current cross cannot be discounted.
T18150 25178-25186 JJ denotes Maternal
T18151 25187-25195 NN denotes genotype
T18152 25196-25203 NNS denotes effects
T18154 25204-25206 IN denotes on
T18155 25207-25213 NN denotes growth
T18156 25214-25217 CC denotes and
T18157 25218-25225 NN denotes obesity
T18158 25226-25230 VBP denotes have
T18159 25231-25235 VBN denotes been
T18153 25236-25244 VBN denotes observed
T18160 25245-25247 IN denotes in
T18161 25248-25249 DT denotes a
T18162 25250-25256 NN denotes number
T18163 25257-25259 IN denotes of
T18164 25260-25265 NN denotes mouse
T18165 25266-25273 NNS denotes crosses
T18166 25274-25275 -LRB- denotes [
T18167 25275-25276 CD denotes 8
T18168 25276-25277 , denotes ,
T18169 25277-25279 CD denotes 32
T18170 25279-25280 SYM denotes -
T18171 25280-25282 CD denotes 35
T18172 25282-25283 -RRB- denotes ]
T18173 25284-25287 CC denotes and
T18174 25288-25293 PRP$ denotes their
T18175 25294-25303 NN denotes existence
T18177 25304-25306 IN denotes in
T18178 25307-25310 DT denotes the
T18180 25311-25318 JJ denotes current
T18179 25319-25324 NN denotes cross
T18181 25325-25328 MD denotes can
T18182 25328-25331 RB denotes not
T18183 25332-25334 VB denotes be
T18176 25335-25345 VBN denotes discounted
T18184 25345-25346 . denotes .
T18185 25346-25475 sentence denotes However, our congenics provide the ideal foundation genomic resource to test for the influence of any of these possible effects.
T18186 25347-25354 RB denotes However
T18188 25354-25356 , denotes ,
T18189 25356-25359 PRP$ denotes our
T18190 25360-25369 NNS denotes congenics
T18187 25370-25377 VBP denotes provide
T18191 25378-25381 DT denotes the
T18193 25382-25387 JJ denotes ideal
T18194 25388-25398 NN denotes foundation
T18195 25399-25406 JJ denotes genomic
T18192 25407-25415 NN denotes resource
T18196 25416-25418 TO denotes to
T18197 25419-25423 VB denotes test
T18198 25424-25427 IN denotes for
T18199 25428-25431 DT denotes the
T18200 25432-25441 NN denotes influence
T18201 25442-25444 IN denotes of
T18202 25445-25448 DT denotes any
T18203 25449-25451 IN denotes of
T18204 25452-25457 DT denotes these
T18206 25458-25466 JJ denotes possible
T18205 25467-25474 NNS denotes effects
T18207 25474-25475 . denotes .
T18208 25475-25664 sentence denotes Future fine mapping experiments can be designed to randomize the influences of any contaminating donor alleles and environmental differences, as well as test for maternal genotype effects.
T18209 25476-25482 JJ denotes Future
T18211 25483-25487 JJ denotes fine
T18212 25488-25495 NN denotes mapping
T18210 25496-25507 NNS denotes experiments
T18214 25508-25511 MD denotes can
T18215 25512-25514 VB denotes be
T18213 25515-25523 VBN denotes designed
T18216 25524-25526 TO denotes to
T18217 25527-25536 VB denotes randomize
T18218 25537-25540 DT denotes the
T18219 25541-25551 NNS denotes influences
T18220 25552-25554 IN denotes of
T18221 25555-25558 DT denotes any
T18223 25559-25572 VBG denotes contaminating
T18224 25573-25578 NN denotes donor
T18222 25579-25586 NNS denotes alleles
T18225 25587-25590 CC denotes and
T18226 25591-25604 JJ denotes environmental
T18227 25605-25616 NNS denotes differences
T18228 25616-25618 , denotes ,
T18229 25618-25620 RB denotes as
T18231 25621-25625 RB denotes well
T18230 25626-25628 IN denotes as
T18232 25629-25633 VB denotes test
T18233 25634-25637 IN denotes for
T18234 25638-25646 JJ denotes maternal
T18235 25647-25655 NN denotes genotype
T18236 25656-25663 NNS denotes effects
T18237 25663-25664 . denotes .
T18238 25664-25710 sentence denotes MMU2 is a hotspot for growth and obesity QTL.
T18239 25665-25669 NN denotes MMU2
T18240 25670-25672 VBZ denotes is
T18241 25673-25674 DT denotes a
T18242 25675-25682 NN denotes hotspot
T18243 25683-25686 IN denotes for
T18244 25687-25693 NN denotes growth
T18246 25694-25697 CC denotes and
T18247 25698-25705 NN denotes obesity
T18245 25706-25709 NN denotes QTL
T18248 25709-25710 . denotes .
T18249 25710-25773 sentence denotes Over 30 QTL have been identified in various experiments [1,2].
T18250 25711-25715 IN denotes Over
T18251 25716-25718 CD denotes 30
T18252 25719-25722 NN denotes QTL
T18254 25723-25727 VBP denotes have
T18255 25728-25732 VBN denotes been
T18253 25733-25743 VBN denotes identified
T18256 25744-25746 IN denotes in
T18257 25747-25754 JJ denotes various
T18258 25755-25766 NNS denotes experiments
T18259 25767-25768 -LRB- denotes [
T18261 25768-25769 CD denotes 1
T18262 25769-25770 , denotes ,
T18260 25770-25771 CD denotes 2
T18263 25771-25772 -RRB- denotes ]
T18264 25772-25773 . denotes .
T18265 25773-25892 sentence denotes Several previously reported or novel MMU2 QTL have been isolated and characterized using congenic strains [7,9-11,36].
T18266 25774-25781 JJ denotes Several
T18268 25782-25792 RB denotes previously
T18269 25793-25801 VBN denotes reported
T18270 25802-25804 CC denotes or
T18271 25805-25810 JJ denotes novel
T18272 25811-25815 NN denotes MMU2
T18267 25816-25819 NN denotes QTL
T18274 25820-25824 VBP denotes have
T18275 25825-25829 VBN denotes been
T18273 25830-25838 VBN denotes isolated
T18276 25839-25842 CC denotes and
T18277 25843-25856 VBN denotes characterized
T18278 25857-25862 VBG denotes using
T18279 25863-25871 JJ denotes congenic
T18280 25872-25879 NNS denotes strains
T18281 25880-25881 -LRB- denotes [
T18282 25881-25882 CD denotes 7
T18283 25882-25883 , denotes ,
T18284 25883-25884 CD denotes 9
T18285 25884-25885 SYM denotes -
T18286 25885-25887 CD denotes 11
T18287 25887-25888 , denotes ,
T18288 25888-25890 CD denotes 36
T18289 25890-25891 -RRB- denotes ]
T18290 25891-25892 . denotes .
T18291 25892-26015 sentence denotes Our findings are no different and indicate that MMU2 is highly complex with regards to genes affecting growth and obesity.
T18292 25893-25896 PRP$ denotes Our
T18293 25897-25905 NNS denotes findings
T18294 25906-25909 VBP denotes are
T18295 25910-25912 DT denotes no
T18296 25913-25922 JJ denotes different
T18297 25923-25926 CC denotes and
T18298 25927-25935 VBP denotes indicate
T18299 25936-25940 IN denotes that
T18301 25941-25945 NN denotes MMU2
T18300 25946-25948 VBZ denotes is
T18302 25949-25955 RB denotes highly
T18303 25956-25963 JJ denotes complex
T18304 25964-25968 IN denotes with
T18305 25969-25976 NNS denotes regards
T18306 25977-25979 IN denotes to
T18307 25980-25985 NNS denotes genes
T18308 25986-25995 VBG denotes affecting
T18309 25996-26002 NN denotes growth
T18310 26003-26006 CC denotes and
T18311 26007-26014 NN denotes obesity
T18312 26014-26015 . denotes .
T18313 26015-26137 sentence denotes The overlapping nature of our MMU2 strains allowed us to parse the chromosome into five regions (Regions I–V) (Figure 2).
T18314 26016-26019 DT denotes The
T18316 26020-26031 VBG denotes overlapping
T18315 26032-26038 NN denotes nature
T18318 26039-26041 IN denotes of
T18319 26042-26045 PRP$ denotes our
T18321 26046-26050 NN denotes MMU2
T18320 26051-26058 NNS denotes strains
T18317 26059-26066 VBD denotes allowed
T18322 26067-26069 PRP denotes us
T18324 26070-26072 TO denotes to
T18323 26073-26078 VB denotes parse
T18325 26079-26082 DT denotes the
T18326 26083-26093 NN denotes chromosome
T18327 26094-26098 IN denotes into
T18328 26099-26103 CD denotes five
T18329 26104-26111 NNS denotes regions
T18330 26112-26113 -LRB- denotes (
T18331 26113-26120 NNS denotes Regions
T18332 26121-26122 CD denotes I
T18333 26122-26123 SYM denotes –
T18334 26123-26124 CD denotes V
T18335 26124-26125 -RRB- denotes )
T18336 26126-26127 -LRB- denotes (
T18337 26127-26133 NN denotes Figure
T18338 26134-26135 CD denotes 2
T18339 26135-26136 -RRB- denotes )
T18340 26136-26137 . denotes .
T18341 26137-26227 sentence denotes The data support the presence of at least one QTL in each of the five regions (Figure 2).
T18342 26138-26141 DT denotes The
T18343 26142-26146 NNS denotes data
T18344 26147-26154 VBP denotes support
T18345 26155-26158 DT denotes the
T18346 26159-26167 NN denotes presence
T18347 26168-26170 IN denotes of
T18348 26171-26173 RB denotes at
T18350 26174-26179 RBS denotes least
T18349 26180-26183 CD denotes one
T18351 26184-26187 NN denotes QTL
T18352 26188-26190 IN denotes in
T18353 26191-26195 DT denotes each
T18354 26196-26198 IN denotes of
T18355 26199-26202 DT denotes the
T18357 26203-26207 CD denotes five
T18356 26208-26215 NNS denotes regions
T18358 26216-26217 -LRB- denotes (
T18359 26217-26223 NN denotes Figure
T18360 26224-26225 CD denotes 2
T18361 26225-26226 -RRB- denotes )
T18362 26226-26227 . denotes .
T18363 26227-26321 sentence denotes Each of the five pleiotropically impact both growth and obesity, although to varying degrees.
T18364 26228-26232 DT denotes Each
T18366 26233-26235 IN denotes of
T18367 26236-26239 DT denotes the
T18368 26240-26244 CD denotes five
T18369 26245-26260 RB denotes pleiotropically
T18365 26261-26267 VBP denotes impact
T18370 26268-26272 CC denotes both
T18371 26273-26279 NN denotes growth
T18372 26280-26283 CC denotes and
T18373 26284-26291 NN denotes obesity
T18374 26291-26293 , denotes ,
T18375 26293-26301 IN denotes although
T18376 26302-26304 IN denotes to
T18377 26305-26312 VBG denotes varying
T18378 26313-26320 NNS denotes degrees
T18379 26320-26321 . denotes .
T18380 26321-26496 sentence denotes In addition to the large number of MMU2 QTL, the presence of hg adds complexity by either eliciting interactions with the same QTL or by inducing the expression of novel QTL.
T18381 26322-26324 IN denotes In
T18383 26325-26333 NN denotes addition
T18384 26334-26336 IN denotes to
T18385 26337-26340 DT denotes the
T18387 26341-26346 JJ denotes large
T18386 26347-26353 NN denotes number
T18388 26354-26356 IN denotes of
T18389 26357-26361 NN denotes MMU2
T18390 26362-26365 NN denotes QTL
T18391 26365-26367 , denotes ,
T18392 26367-26370 DT denotes the
T18393 26371-26379 NN denotes presence
T18394 26380-26382 IN denotes of
T18395 26383-26385 NN denotes hg
T18382 26386-26390 VBZ denotes adds
T18396 26391-26401 NN denotes complexity
T18397 26402-26404 IN denotes by
T18398 26405-26411 CC denotes either
T18399 26412-26421 VBG denotes eliciting
T18400 26422-26434 NNS denotes interactions
T18401 26435-26439 IN denotes with
T18402 26440-26443 DT denotes the
T18404 26444-26448 JJ denotes same
T18403 26449-26452 NN denotes QTL
T18405 26453-26455 CC denotes or
T18406 26456-26458 IN denotes by
T18407 26459-26467 VBG denotes inducing
T18408 26468-26471 DT denotes the
T18409 26472-26482 NN denotes expression
T18410 26483-26485 IN denotes of
T18411 26486-26491 JJ denotes novel
T18412 26492-26495 NN denotes QTL
T18413 26495-26496 . denotes .
T18414 26496-26623 sentence denotes The 2P unique region (Region I) contains an hg modifier with large effects on growth and smaller effects on obesity (Table 3).
T18415 26497-26500 DT denotes The
T18417 26501-26503 NN denotes 2P
T18418 26504-26510 JJ denotes unique
T18416 26511-26517 NN denotes region
T18420 26518-26519 -LRB- denotes (
T18421 26519-26525 NN denotes Region
T18422 26526-26527 CD denotes I
T18423 26527-26528 -RRB- denotes )
T18419 26529-26537 VBZ denotes contains
T18424 26538-26540 DT denotes an
T18426 26541-26543 NN denotes hg
T18425 26544-26552 NN denotes modifier
T18427 26553-26557 IN denotes with
T18428 26558-26563 JJ denotes large
T18429 26564-26571 NNS denotes effects
T18430 26572-26574 IN denotes on
T18431 26575-26581 NN denotes growth
T18432 26582-26585 CC denotes and
T18433 26586-26593 JJR denotes smaller
T18434 26594-26601 NNS denotes effects
T18435 26602-26604 IN denotes on
T18436 26605-26612 NN denotes obesity
T18437 26613-26614 -LRB- denotes (
T18438 26614-26619 NN denotes Table
T18439 26620-26621 CD denotes 3
T18440 26621-26622 -RRB- denotes )
T18441 26622-26623 . denotes .
T18442 26623-26718 sentence denotes In contrast, interactions between 2PM/2M QTL and hg primarily affect fat deposition (Table 3).
T18443 26624-26626 IN denotes In
T18445 26627-26635 NN denotes contrast
T18446 26635-26637 , denotes ,
T18447 26637-26649 NNS denotes interactions
T18448 26650-26657 IN denotes between
T18449 26658-26661 NN denotes 2PM
T18451 26661-26662 HYPH denotes /
T18450 26662-26664 NN denotes 2M
T18452 26665-26668 NN denotes QTL
T18453 26669-26672 CC denotes and
T18454 26673-26675 NN denotes hg
T18455 26676-26685 RB denotes primarily
T18444 26686-26692 VBP denotes affect
T18456 26693-26696 NN denotes fat
T18457 26697-26707 NN denotes deposition
T18458 26708-26709 -LRB- denotes (
T18459 26709-26714 NN denotes Table
T18460 26715-26716 CD denotes 3
T18461 26716-26717 -RRB- denotes )
T18462 26717-26718 . denotes .
T18463 26718-26848 sentence denotes As illustrated in Figure 4 the 2M donor region exhibits strong sex effects on the rate of lipid storage, dependent on background.
T18464 26719-26721 IN denotes As
T18465 26722-26733 VBN denotes illustrated
T18467 26734-26736 IN denotes in
T18468 26737-26743 NN denotes Figure
T18469 26744-26745 CD denotes 4
T18470 26746-26749 DT denotes the
T18472 26750-26752 NN denotes 2M
T18473 26753-26758 NN denotes donor
T18471 26759-26765 NN denotes region
T18466 26766-26774 VBZ denotes exhibits
T18474 26775-26781 JJ denotes strong
T18476 26782-26785 NN denotes sex
T18475 26786-26793 NNS denotes effects
T18477 26794-26796 IN denotes on
T18478 26797-26800 DT denotes the
T18479 26801-26805 NN denotes rate
T18480 26806-26808 IN denotes of
T18481 26809-26814 NN denotes lipid
T18482 26815-26822 NN denotes storage
T18483 26822-26824 , denotes ,
T18484 26824-26833 JJ denotes dependent
T18485 26834-26836 IN denotes on
T18486 26837-26847 NN denotes background
T18487 26847-26848 . denotes .
T18488 26848-26946 sentence denotes In control mice, HGC females have a higher AI than males, while the opposite is seen in B6C mice.
T18489 26849-26851 IN denotes In
T18491 26852-26859 NN denotes control
T18492 26860-26864 NNS denotes mice
T18493 26864-26866 , denotes ,
T18494 26866-26869 NN denotes HGC
T18495 26870-26877 NNS denotes females
T18490 26878-26882 VBP denotes have
T18496 26883-26884 DT denotes a
T18498 26885-26891 JJR denotes higher
T18497 26892-26894 NN denotes AI
T18499 26895-26899 IN denotes than
T18500 26900-26905 NNS denotes males
T18501 26905-26907 , denotes ,
T18502 26907-26912 IN denotes while
T18504 26913-26916 DT denotes the
T18505 26917-26925 NN denotes opposite
T18506 26926-26928 VBZ denotes is
T18503 26929-26933 VBN denotes seen
T18507 26934-26936 IN denotes in
T18508 26937-26940 NN denotes B6C
T18509 26941-26945 NNS denotes mice
T18510 26945-26946 . denotes .
T18511 26946-27052 sentence denotes Interestingly, the 2M hg modifier QTL abolished the hg induced sexual dimorphism in adiposity (Figure 4).
T18512 26947-26960 RB denotes Interestingly
T18514 26960-26962 , denotes ,
T18515 26962-26965 DT denotes the
T18517 26966-26968 NN denotes 2M
T18518 26969-26971 NN denotes hg
T18519 26972-26980 NN denotes modifier
T18516 26981-26984 NN denotes QTL
T18513 26985-26994 VBD denotes abolished
T18520 26995-26998 DT denotes the
T18522 26999-27001 NN denotes hg
T18523 27002-27009 VBN denotes induced
T18524 27010-27016 JJ denotes sexual
T18521 27017-27027 NN denotes dimorphism
T18525 27028-27030 IN denotes in
T18526 27031-27040 NN denotes adiposity
T18527 27041-27042 -LRB- denotes (
T18528 27042-27048 NN denotes Figure
T18529 27049-27050 CD denotes 4
T18530 27050-27051 -RRB- denotes )
T18531 27051-27052 . denotes .
T18532 27052-27217 sentence denotes Although these results provide insight into the nature of hg modifier QTL, it should be noted, that the actual number and precise location of loci is still unclear.
T18533 27053-27061 IN denotes Although
T18535 27062-27067 DT denotes these
T18536 27068-27075 NNS denotes results
T18534 27076-27083 VBP denotes provide
T18538 27084-27091 NN denotes insight
T18539 27092-27096 IN denotes into
T18540 27097-27100 DT denotes the
T18541 27101-27107 NN denotes nature
T18542 27108-27110 IN denotes of
T18543 27111-27113 NN denotes hg
T18544 27114-27122 NN denotes modifier
T18545 27123-27126 NN denotes QTL
T18546 27126-27128 , denotes ,
T18547 27128-27130 PRP denotes it
T18548 27131-27137 MD denotes should
T18549 27138-27140 VB denotes be
T18537 27141-27146 VBN denotes noted
T18550 27146-27148 , denotes ,
T18551 27148-27152 IN denotes that
T18553 27153-27156 DT denotes the
T18555 27157-27163 JJ denotes actual
T18554 27164-27170 NN denotes number
T18556 27171-27174 CC denotes and
T18557 27175-27182 JJ denotes precise
T18558 27183-27191 NN denotes location
T18559 27192-27194 IN denotes of
T18560 27195-27199 NNS denotes loci
T18552 27200-27202 VBZ denotes is
T18561 27203-27208 RB denotes still
T18562 27209-27216 JJ denotes unclear
T18563 27216-27217 . denotes .
T18564 27217-27307 sentence denotes In addition to MMU2, three other congenics (HG9, HG11 and HG17) captured hg modifier QTL.
T18565 27218-27220 IN denotes In
T18567 27221-27229 NN denotes addition
T18568 27230-27232 IN denotes to
T18569 27233-27237 NN denotes MMU2
T18570 27237-27239 , denotes ,
T18571 27239-27244 CD denotes three
T18573 27245-27250 JJ denotes other
T18572 27251-27260 NNS denotes congenics
T18574 27261-27262 -LRB- denotes (
T18575 27262-27265 NN denotes HG9
T18576 27265-27267 , denotes ,
T18577 27267-27271 NN denotes HG11
T18578 27272-27275 CC denotes and
T18579 27276-27280 NN denotes HG17
T18580 27280-27281 -RRB- denotes )
T18566 27282-27290 VBD denotes captured
T18581 27291-27293 NN denotes hg
T18582 27294-27302 NN denotes modifier
T18583 27303-27306 NN denotes QTL
T18584 27306-27307 . denotes .
T18585 27307-27409 sentence denotes In classical terms, they are QTL which modify the expressivity of growth and obesity in HG mice [18].
T18586 27308-27310 IN denotes In
T18588 27311-27320 JJ denotes classical
T18589 27321-27326 NNS denotes terms
T18590 27326-27328 , denotes ,
T18591 27328-27332 PRP denotes they
T18587 27333-27336 VBP denotes are
T18592 27337-27340 NN denotes QTL
T18593 27341-27346 WDT denotes which
T18594 27347-27353 VBP denotes modify
T18595 27354-27357 DT denotes the
T18596 27358-27370 NN denotes expressivity
T18597 27371-27373 IN denotes of
T18598 27374-27380 NN denotes growth
T18599 27381-27384 CC denotes and
T18600 27385-27392 NN denotes obesity
T18601 27393-27395 IN denotes in
T18602 27396-27398 NN denotes HG
T18603 27399-27403 NNS denotes mice
T18604 27404-27405 -LRB- denotes [
T18605 27405-27407 CD denotes 18
T18606 27407-27408 -RRB- denotes ]
T18607 27408-27409 . denotes .
T18608 27409-27494 sentence denotes These QTL are novel since they represent epistasis between hg and the modifier gene.
T18609 27410-27415 DT denotes These
T18610 27416-27419 NN denotes QTL
T18611 27420-27423 VBP denotes are
T18612 27424-27429 JJ denotes novel
T18613 27430-27435 IN denotes since
T18615 27436-27440 PRP denotes they
T18614 27441-27450 VBP denotes represent
T18616 27451-27460 NN denotes epistasis
T18617 27461-27468 IN denotes between
T18618 27469-27471 NN denotes hg
T18619 27472-27475 CC denotes and
T18620 27476-27479 DT denotes the
T18622 27480-27488 NN denotes modifier
T18621 27489-27493 NN denotes gene
T18623 27493-27494 . denotes .
T18624 27494-27587 sentence denotes QTL-hg epistasis implies that Socs2 and the hg modifiers are in the same biological pathway.
T18625 27495-27498 NN denotes QTL
T18627 27498-27499 HYPH denotes -
T18626 27499-27501 NN denotes hg
T18628 27502-27511 NN denotes epistasis
T18629 27512-27519 VBZ denotes implies
T18630 27520-27524 IN denotes that
T18632 27525-27530 NN denotes Socs2
T18633 27531-27534 CC denotes and
T18634 27535-27538 DT denotes the
T18636 27539-27541 NN denotes hg
T18635 27542-27551 NNS denotes modifiers
T18631 27552-27555 VBP denotes are
T18637 27556-27558 IN denotes in
T18638 27559-27562 DT denotes the
T18640 27563-27567 JJ denotes same
T18641 27568-27578 JJ denotes biological
T18639 27579-27586 NN denotes pathway
T18642 27586-27587 . denotes .
T18643 27587-27729 sentence denotes Therefore, these QTL are likely due to polymorphism in genes interacting with Gh, responsive to Gh or which in some way modulate Gh function.
T18644 27588-27597 RB denotes Therefore
T18646 27597-27599 , denotes ,
T18647 27599-27604 DT denotes these
T18648 27605-27608 NN denotes QTL
T18645 27609-27612 VBP denotes are
T18649 27613-27619 RB denotes likely
T18650 27620-27623 IN denotes due
T18651 27624-27626 IN denotes to
T18652 27627-27639 NN denotes polymorphism
T18653 27640-27642 IN denotes in
T18654 27643-27648 NNS denotes genes
T18655 27649-27660 VBG denotes interacting
T18656 27661-27665 IN denotes with
T18657 27666-27668 NN denotes Gh
T18658 27668-27670 , denotes ,
T18659 27670-27680 JJ denotes responsive
T18660 27681-27683 IN denotes to
T18661 27684-27686 NN denotes Gh
T18662 27687-27689 CC denotes or
T18663 27690-27695 WDT denotes which
T18665 27696-27698 IN denotes in
T18666 27699-27703 DT denotes some
T18667 27704-27707 NN denotes way
T18664 27708-27716 VBP denotes modulate
T18668 27717-27719 NN denotes Gh
T18669 27720-27728 NN denotes function
T18670 27728-27729 . denotes .
T18671 27729-27831 sentence denotes This information will significantly aid QTL cloning by providing another filter to screen candidates.
T18672 27730-27734 DT denotes This
T18673 27735-27746 NN denotes information
T18675 27747-27751 MD denotes will
T18676 27752-27765 RB denotes significantly
T18674 27766-27769 VB denotes aid
T18677 27770-27773 NN denotes QTL
T18678 27774-27781 NN denotes cloning
T18679 27782-27784 IN denotes by
T18680 27785-27794 VBG denotes providing
T18681 27795-27802 DT denotes another
T18682 27803-27809 NN denotes filter
T18683 27810-27812 TO denotes to
T18684 27813-27819 VB denotes screen
T18685 27820-27830 NNS denotes candidates
T18686 27830-27831 . denotes .
T18687 27831-28002 sentence denotes Cloning these QTL has major implications to improve our understanding of Gh and its regulation of growth and adiposity and in the administration of human Gh therapeutics.
T18688 27832-27839 VBG denotes Cloning
T18690 27840-27845 DT denotes these
T18689 27846-27849 NN denotes QTL
T18691 27850-27853 VBZ denotes has
T18692 27854-27859 JJ denotes major
T18693 27860-27872 NNS denotes implications
T18694 27873-27875 TO denotes to
T18695 27876-27883 VB denotes improve
T18696 27884-27887 PRP$ denotes our
T18697 27888-27901 NN denotes understanding
T18698 27902-27904 IN denotes of
T18699 27905-27907 NN denotes Gh
T18700 27908-27911 CC denotes and
T18701 27912-27915 PRP$ denotes its
T18702 27916-27926 NN denotes regulation
T18703 27927-27929 IN denotes of
T18704 27930-27936 NN denotes growth
T18705 27937-27940 CC denotes and
T18706 27941-27950 NN denotes adiposity
T18707 27951-27954 CC denotes and
T18708 27955-27957 IN denotes in
T18709 27958-27961 DT denotes the
T18710 27962-27976 NN denotes administration
T18711 27977-27979 IN denotes of
T18712 27980-27985 JJ denotes human
T18713 27986-27988 NN denotes Gh
T18714 27989-28001 NNS denotes therapeutics
T18715 28001-28002 . denotes .
T18716 28002-28056 sentence denotes HG1 mice displayed differences only in growth traits.
T18717 28003-28006 NN denotes HG1
T18718 28007-28011 NNS denotes mice
T18719 28012-28021 VBD denotes displayed
T18720 28022-28033 NNS denotes differences
T18721 28034-28038 RB denotes only
T18722 28039-28041 IN denotes in
T18723 28042-28048 NN denotes growth
T18724 28049-28055 NNS denotes traits
T18725 28055-28056 . denotes .
T18726 28056-28295 sentence denotes Originally, Q1Ucd1 had small effects and these results illustrate the power of congenic strain analysis to isolate small effect QTL, although it is likely this QTL represents the lower boundary of detection using only 20–30 congenic mice.
T18727 28057-28067 RB denotes Originally
T18729 28067-28069 , denotes ,
T18730 28069-28075 NN denotes Q1Ucd1
T18728 28076-28079 VBD denotes had
T18731 28080-28085 JJ denotes small
T18732 28086-28093 NNS denotes effects
T18733 28094-28097 CC denotes and
T18734 28098-28103 DT denotes these
T18735 28104-28111 NNS denotes results
T18736 28112-28122 VBP denotes illustrate
T18737 28123-28126 DT denotes the
T18738 28127-28132 NN denotes power
T18739 28133-28135 IN denotes of
T18740 28136-28144 JJ denotes congenic
T18741 28145-28151 NN denotes strain
T18742 28152-28160 NN denotes analysis
T18743 28161-28163 TO denotes to
T18744 28164-28171 VB denotes isolate
T18745 28172-28177 JJ denotes small
T18746 28178-28184 NN denotes effect
T18747 28185-28188 NN denotes QTL
T18748 28188-28190 , denotes ,
T18749 28190-28198 IN denotes although
T18751 28199-28201 PRP denotes it
T18750 28202-28204 VBZ denotes is
T18752 28205-28211 JJ denotes likely
T18753 28212-28216 DT denotes this
T18754 28217-28220 NN denotes QTL
T18755 28221-28231 VBZ denotes represents
T18756 28232-28235 DT denotes the
T18758 28236-28241 JJR denotes lower
T18757 28242-28250 NN denotes boundary
T18759 28251-28253 IN denotes of
T18760 28254-28263 NN denotes detection
T18761 28264-28269 VBG denotes using
T18762 28270-28274 RB denotes only
T18764 28275-28277 CD denotes 20
T18765 28277-28278 SYM denotes –
T18763 28278-28280 CD denotes 30
T18767 28281-28289 JJ denotes congenic
T18766 28290-28294 NNS denotes mice
T18768 28294-28295 . denotes .
T18769 28295-28438 sentence denotes The most notable candidate genes located within the HG1 interval are the signal transducer and activator of transcription 1 (Stat1) and Stat4.
T18770 28296-28299 DT denotes The
T18772 28300-28304 RBS denotes most
T18773 28305-28312 JJ denotes notable
T18774 28313-28322 NN denotes candidate
T18771 28323-28328 NNS denotes genes
T18776 28329-28336 VBN denotes located
T18777 28337-28343 IN denotes within
T18778 28344-28347 DT denotes the
T18780 28348-28351 NN denotes HG1
T18779 28352-28360 NN denotes interval
T18775 28361-28364 VBP denotes are
T18781 28365-28368 DT denotes the
T18783 28369-28375 NN denotes signal
T18782 28376-28386 NN denotes transducer
T18784 28387-28390 CC denotes and
T18785 28391-28400 NN denotes activator
T18786 28401-28403 IN denotes of
T18787 28404-28417 NN denotes transcription
T18788 28418-28419 CD denotes 1
T18789 28420-28421 -LRB- denotes (
T18790 28421-28426 NN denotes Stat1
T18791 28426-28427 -RRB- denotes )
T18792 28428-28431 CC denotes and
T18793 28432-28437 NN denotes Stat4
T18794 28437-28438 . denotes .
T18795 28438-28531 sentence denotes Two of the congenics had major alterations in the deposition of adipose tissue, HG8 and HG9.
T18796 28439-28442 CD denotes Two
T18798 28443-28445 IN denotes of
T18799 28446-28449 DT denotes the
T18800 28450-28459 NNS denotes congenics
T18797 28460-28463 VBD denotes had
T18801 28464-28469 JJ denotes major
T18802 28470-28481 NNS denotes alterations
T18803 28482-28484 IN denotes in
T18804 28485-28488 DT denotes the
T18805 28489-28499 NN denotes deposition
T18806 28500-28502 IN denotes of
T18807 28503-28510 NN denotes adipose
T18808 28511-28517 NN denotes tissue
T18809 28517-28519 , denotes ,
T18810 28519-28522 NN denotes HG8
T18811 28523-28526 CC denotes and
T18812 28527-28530 NN denotes HG9
T18813 28530-28531 . denotes .
T18814 28531-28571 sentence denotes The HG8 donor region promotes leanness.
T18815 28532-28535 DT denotes The
T18817 28536-28539 NN denotes HG8
T18818 28540-28545 NN denotes donor
T18816 28546-28552 NN denotes region
T18819 28553-28561 VBZ denotes promotes
T18820 28562-28570 NN denotes leanness
T18821 28570-28571 . denotes .
T18822 28571-28629 sentence denotes Congenic females displayed a reduction of over 25% in AI.
T18823 28572-28580 JJ denotes Congenic
T18824 28581-28588 NNS denotes females
T18825 28589-28598 VBD denotes displayed
T18826 28599-28600 DT denotes a
T18827 28601-28610 NN denotes reduction
T18828 28611-28613 IN denotes of
T18829 28614-28618 IN denotes over
T18830 28619-28621 CD denotes 25
T18831 28621-28622 NN denotes %
T18832 28623-28625 IN denotes in
T18833 28626-28628 NN denotes AI
T18834 28628-28629 . denotes .
T18835 28629-28682 sentence denotes In contrast, the HG9 strain is an obese mouse model.
T18836 28630-28632 IN denotes In
T18838 28633-28641 NN denotes contrast
T18839 28641-28643 , denotes ,
T18840 28643-28646 DT denotes the
T18842 28647-28650 NN denotes HG9
T18841 28651-28657 NN denotes strain
T18837 28658-28660 VBZ denotes is
T18843 28661-28663 DT denotes an
T18845 28664-28669 JJ denotes obese
T18846 28670-28675 NN denotes mouse
T18844 28676-28681 NN denotes model
T18847 28681-28682 . denotes .
T18848 28682-28725 sentence denotes The strain is quite novel for two reasons.
T18849 28683-28686 DT denotes The
T18850 28687-28693 NN denotes strain
T18851 28694-28696 VBZ denotes is
T18852 28697-28702 RB denotes quite
T18853 28703-28708 JJ denotes novel
T18854 28709-28712 IN denotes for
T18855 28713-28716 CD denotes two
T18856 28717-28724 NNS denotes reasons
T18857 28724-28725 . denotes .
T18858 28725-28816 sentence denotes First, the effect size is large; AI was 57% higher in HG9 females and 30% higher in males.
T18859 28726-28731 RB denotes First
T18861 28731-28733 , denotes ,
T18862 28733-28736 DT denotes the
T18864 28737-28743 NN denotes effect
T18863 28744-28748 NN denotes size
T18865 28749-28751 VBZ denotes is
T18866 28752-28757 JJ denotes large
T18867 28757-28758 : denotes ;
T18868 28759-28761 NN denotes AI
T18860 28762-28765 VBD denotes was
T18869 28766-28768 CD denotes 57
T18870 28768-28769 NN denotes %
T18871 28770-28776 JJR denotes higher
T18872 28777-28779 IN denotes in
T18873 28780-28783 NN denotes HG9
T18874 28784-28791 NNS denotes females
T18875 28792-28795 CC denotes and
T18876 28796-28798 CD denotes 30
T18877 28798-28799 NN denotes %
T18878 28800-28806 JJR denotes higher
T18879 28807-28809 IN denotes in
T18880 28810-28815 NNS denotes males
T18881 28815-28816 . denotes .
T18882 28816-28868 sentence denotes Secondly, it is dependent on hg for its expression.
T18883 28817-28825 RB denotes Secondly
T18885 28825-28827 , denotes ,
T18886 28827-28829 PRP denotes it
T18884 28830-28832 VBZ denotes is
T18887 28833-28842 JJ denotes dependent
T18888 28843-28845 IN denotes on
T18889 28846-28848 NN denotes hg
T18890 28849-28852 IN denotes for
T18891 28853-28856 PRP$ denotes its
T18892 28857-28867 NN denotes expression
T18893 28867-28868 . denotes .
T18894 28868-29056 sentence denotes The HG9 strain represents a major epistasis-based obese mouse model and promises to aid in the understanding of obesity and specifically the modulation of adipose tissue deposition by Gh.
T18895 28869-28872 DT denotes The
T18897 28873-28876 NN denotes HG9
T18896 28877-28883 NN denotes strain
T18898 28884-28894 VBZ denotes represents
T18899 28895-28896 DT denotes a
T18901 28897-28902 JJ denotes major
T18902 28903-28912 NN denotes epistasis
T18904 28912-28913 HYPH denotes -
T18903 28913-28918 VBN denotes based
T18905 28919-28924 JJ denotes obese
T18906 28925-28930 NN denotes mouse
T18900 28931-28936 NN denotes model
T18907 28937-28940 CC denotes and
T18908 28941-28949 VBZ denotes promises
T18909 28950-28952 TO denotes to
T18910 28953-28956 VB denotes aid
T18911 28957-28959 IN denotes in
T18912 28960-28963 DT denotes the
T18913 28964-28977 NN denotes understanding
T18914 28978-28980 IN denotes of
T18915 28981-28988 NN denotes obesity
T18916 28989-28992 CC denotes and
T18917 28993-29005 RB denotes specifically
T18919 29006-29009 DT denotes the
T18918 29010-29020 NN denotes modulation
T18920 29021-29023 IN denotes of
T18921 29024-29031 NN denotes adipose
T18922 29032-29038 NN denotes tissue
T18923 29039-29049 NN denotes deposition
T18924 29050-29052 IN denotes by
T18925 29053-29055 NN denotes Gh
T18926 29055-29056 . denotes .
T18927 29056-29312 sentence denotes Studies are currently underway to identify the causative mutation and to characterize the effects of age and diet on obesity in this strain as well as testing for other physiological consequences such as alterations in food intake and insulin sensitivity.
T18928 29057-29064 NNS denotes Studies
T18929 29065-29068 VBP denotes are
T18930 29069-29078 RB denotes currently
T18931 29079-29087 JJ denotes underway
T18932 29088-29090 TO denotes to
T18933 29091-29099 VB denotes identify
T18934 29100-29103 DT denotes the
T18936 29104-29113 JJ denotes causative
T18935 29114-29122 NN denotes mutation
T18937 29123-29126 CC denotes and
T18938 29127-29129 TO denotes to
T18939 29130-29142 VB denotes characterize
T18940 29143-29146 DT denotes the
T18941 29147-29154 NNS denotes effects
T18942 29155-29157 IN denotes of
T18943 29158-29161 NN denotes age
T18944 29162-29165 CC denotes and
T18945 29166-29170 NN denotes diet
T18946 29171-29173 IN denotes on
T18947 29174-29181 NN denotes obesity
T18948 29182-29184 IN denotes in
T18949 29185-29189 DT denotes this
T18950 29190-29196 NN denotes strain
T18951 29197-29199 RB denotes as
T18953 29200-29204 RB denotes well
T18952 29205-29207 IN denotes as
T18954 29208-29215 NN denotes testing
T18955 29216-29219 IN denotes for
T18956 29220-29225 JJ denotes other
T18958 29226-29239 JJ denotes physiological
T18957 29240-29252 NNS denotes consequences
T18959 29253-29257 JJ denotes such
T18960 29258-29260 IN denotes as
T18961 29261-29272 NNS denotes alterations
T18962 29273-29275 IN denotes in
T18963 29276-29280 NN denotes food
T18964 29281-29287 NN denotes intake
T18965 29288-29291 CC denotes and
T18966 29292-29299 NN denotes insulin
T18967 29300-29311 NN denotes sensitivity
T18968 29311-29312 . denotes .
T18969 29312-29379 sentence denotes The HG11 strain is of particular interest for a number of reasons.
T18970 29313-29316 DT denotes The
T18972 29317-29321 NN denotes HG11
T18971 29322-29328 NN denotes strain
T18973 29329-29331 VBZ denotes is
T18974 29332-29334 IN denotes of
T18975 29335-29345 JJ denotes particular
T18976 29346-29354 NN denotes interest
T18977 29355-29358 IN denotes for
T18978 29359-29360 DT denotes a
T18979 29361-29367 NN denotes number
T18980 29368-29370 IN denotes of
T18981 29371-29378 NNS denotes reasons
T18982 29378-29379 . denotes .
T18983 29379-29481 sentence denotes First, HG11 congenic mice demonstrated significant strain by sex interactions for a number of traits.
T18984 29380-29385 RB denotes First
T18986 29385-29387 , denotes ,
T18987 29387-29391 NN denotes HG11
T18988 29392-29400 JJ denotes congenic
T18989 29401-29405 NNS denotes mice
T18985 29406-29418 VBD denotes demonstrated
T18990 29419-29430 JJ denotes significant
T18992 29431-29437 NN denotes strain
T18993 29438-29440 IN denotes by
T18994 29441-29444 NN denotes sex
T18991 29445-29457 NNS denotes interactions
T18995 29458-29461 IN denotes for
T18996 29462-29463 DT denotes a
T18997 29464-29470 NN denotes number
T18998 29471-29473 IN denotes of
T18999 29474-29480 NNS denotes traits
T19000 29480-29481 . denotes .
T19001 29481-29574 sentence denotes Males were generally larger, faster growing and longer and the converse was seen in females.
T19002 29482-29487 NNS denotes Males
T19003 29488-29492 VBD denotes were
T19004 29493-29502 RB denotes generally
T19005 29503-29509 JJR denotes larger
T19006 29509-29511 , denotes ,
T19007 29511-29517 JJR denotes faster
T19008 29518-29525 VBG denotes growing
T19009 29526-29529 CC denotes and
T19010 29530-29536 JJR denotes longer
T19011 29537-29540 CC denotes and
T19012 29541-29544 DT denotes the
T19013 29545-29553 NN denotes converse
T19015 29554-29557 VBD denotes was
T19014 29558-29562 VBN denotes seen
T19016 29563-29565 IN denotes in
T19017 29566-29573 NNS denotes females
T19018 29573-29574 . denotes .
T19019 29574-29736 sentence denotes The confounding effects of sex are likely the reason for the discrepancies between the congenic and genome scan results, where both sexes were analyzed together.
T19020 29575-29578 DT denotes The
T19022 29579-29590 VBG denotes confounding
T19021 29591-29598 NNS denotes effects
T19024 29599-29601 IN denotes of
T19025 29602-29605 NN denotes sex
T19023 29606-29609 VBP denotes are
T19026 29610-29616 RB denotes likely
T19027 29617-29620 DT denotes the
T19028 29621-29627 NN denotes reason
T19029 29628-29631 IN denotes for
T19030 29632-29635 DT denotes the
T19031 29636-29649 NNS denotes discrepancies
T19032 29650-29657 IN denotes between
T19033 29658-29661 DT denotes the
T19035 29662-29670 JJ denotes congenic
T19037 29671-29674 CC denotes and
T19036 29675-29681 NN denotes genome
T19038 29682-29686 NN denotes scan
T19034 29687-29694 NNS denotes results
T19039 29694-29696 , denotes ,
T19040 29696-29701 WRB denotes where
T19042 29702-29706 DT denotes both
T19043 29707-29712 NNS denotes sexes
T19044 29713-29717 VBD denotes were
T19041 29718-29726 VBN denotes analyzed
T19045 29727-29735 RB denotes together
T19046 29735-29736 . denotes .
T19047 29736-29907 sentence denotes Secondly, Carp2 was found to interact with hg and MMU11 is saturated with genes involved in the central Gh intracellular signaling pathway, such as Gh, Stat5b and Stat5a.
T19048 29737-29745 RB denotes Secondly
T19050 29745-29747 , denotes ,
T19051 29747-29752 NN denotes Carp2
T19052 29753-29756 VBD denotes was
T19049 29757-29762 VBN denotes found
T19053 29763-29765 TO denotes to
T19054 29766-29774 VB denotes interact
T19055 29775-29779 IN denotes with
T19056 29780-29782 NN denotes hg
T19057 29783-29786 CC denotes and
T19058 29787-29792 NN denotes MMU11
T19060 29793-29795 VBZ denotes is
T19059 29796-29805 VBN denotes saturated
T19061 29806-29810 IN denotes with
T19062 29811-29816 NNS denotes genes
T19063 29817-29825 VBN denotes involved
T19064 29826-29828 IN denotes in
T19065 29829-29832 DT denotes the
T19067 29833-29840 JJ denotes central
T19068 29841-29843 NN denotes Gh
T19069 29844-29857 JJ denotes intracellular
T19070 29858-29867 NN denotes signaling
T19066 29868-29875 NN denotes pathway
T19071 29875-29877 , denotes ,
T19072 29877-29881 JJ denotes such
T19073 29882-29884 IN denotes as
T19074 29885-29887 NN denotes Gh
T19075 29887-29889 , denotes ,
T19076 29889-29895 NN denotes Stat5b
T19077 29896-29899 CC denotes and
T19078 29900-29906 NN denotes Stat5a
T19079 29906-29907 . denotes .
T19080 29907-30033 sentence denotes Thirdly, MMU11 growth QTL overlapping HG11 have been identified in a number of crosses using different mouse strains [37-41].
T19081 29908-29915 RB denotes Thirdly
T19083 29915-29917 , denotes ,
T19084 29917-29922 NN denotes MMU11
T19086 29923-29929 NN denotes growth
T19085 29930-29933 NN denotes QTL
T19087 29934-29945 VBG denotes overlapping
T19088 29946-29950 NN denotes HG11
T19089 29951-29955 VBP denotes have
T19090 29956-29960 VBN denotes been
T19082 29961-29971 VBN denotes identified
T19091 29972-29974 IN denotes in
T19092 29975-29976 DT denotes a
T19093 29977-29983 NN denotes number
T19094 29984-29986 IN denotes of
T19095 29987-29994 NNS denotes crosses
T19096 29995-30000 VBG denotes using
T19097 30001-30010 JJ denotes different
T19099 30011-30016 NN denotes mouse
T19098 30017-30024 NNS denotes strains
T19100 30025-30026 -LRB- denotes [
T19101 30026-30028 CD denotes 37
T19102 30028-30029 SYM denotes -
T19103 30029-30031 CD denotes 41
T19104 30031-30032 -RRB- denotes ]
T19105 30032-30033 . denotes .
T19106 30033-30270 sentence denotes Given the well documented sexually dimorphic nature of Gh secretion and Gh induced gene expression [42,43], it is probable that the underlying mutation in the HG11 congenic may reside in a gene enhancing Gh induced sex-specific effects.
T19107 30034-30039 VBN denotes Given
T19109 30040-30043 DT denotes the
T19111 30044-30048 RB denotes well
T19112 30049-30059 VBN denotes documented
T19113 30060-30068 RB denotes sexually
T19114 30069-30078 JJ denotes dimorphic
T19110 30079-30085 NN denotes nature
T19115 30086-30088 IN denotes of
T19116 30089-30091 NN denotes Gh
T19117 30092-30101 NN denotes secretion
T19118 30102-30105 CC denotes and
T19119 30106-30108 NN denotes Gh
T19120 30109-30116 VBN denotes induced
T19122 30117-30121 NN denotes gene
T19121 30122-30132 NN denotes expression
T19123 30133-30134 -LRB- denotes [
T19125 30134-30136 CD denotes 42
T19126 30136-30137 , denotes ,
T19124 30137-30139 CD denotes 43
T19127 30139-30140 -RRB- denotes ]
T19128 30140-30142 , denotes ,
T19129 30142-30144 PRP denotes it
T19108 30145-30147 VBZ denotes is
T19130 30148-30156 JJ denotes probable
T19131 30157-30161 IN denotes that
T19133 30162-30165 DT denotes the
T19135 30166-30176 VBG denotes underlying
T19134 30177-30185 NN denotes mutation
T19136 30186-30188 IN denotes in
T19137 30189-30192 DT denotes the
T19138 30193-30197 NN denotes HG11
T19139 30198-30206 JJ denotes congenic
T19140 30207-30210 MD denotes may
T19132 30211-30217 VB denotes reside
T19141 30218-30220 IN denotes in
T19142 30221-30222 DT denotes a
T19143 30223-30227 NN denotes gene
T19144 30228-30237 VBG denotes enhancing
T19145 30238-30240 NN denotes Gh
T19146 30241-30248 VBN denotes induced
T19148 30249-30252 NN denotes sex
T19150 30252-30253 HYPH denotes -
T19149 30253-30261 JJ denotes specific
T19147 30262-30269 NNS denotes effects
T19151 30269-30270 . denotes .
T19152 30270-30337 sentence denotes The structural Gh gene itself and Stat5b are excellent candidates.
T19153 30271-30274 DT denotes The
T19155 30275-30285 JJ denotes structural
T19156 30286-30288 NN denotes Gh
T19154 30289-30293 NN denotes gene
T19158 30294-30300 PRP denotes itself
T19159 30301-30304 CC denotes and
T19160 30305-30311 NN denotes Stat5b
T19157 30312-30315 VBP denotes are
T19161 30316-30325 JJ denotes excellent
T19162 30326-30336 NNS denotes candidates
T19163 30336-30337 . denotes .
T19164 30337-30493 sentence denotes The potential role of Gh would include polymorphism that alters protein function in the absence of Socs2 or that causes transcriptional deregulation of Gh.
T19165 30338-30341 DT denotes The
T19167 30342-30351 JJ denotes potential
T19166 30352-30356 NN denotes role
T19169 30357-30359 IN denotes of
T19170 30360-30362 NN denotes Gh
T19171 30363-30368 MD denotes would
T19168 30369-30376 VB denotes include
T19172 30377-30389 NN denotes polymorphism
T19173 30390-30394 WDT denotes that
T19174 30395-30401 VBZ denotes alters
T19175 30402-30409 NN denotes protein
T19176 30410-30418 NN denotes function
T19177 30419-30421 IN denotes in
T19178 30422-30425 DT denotes the
T19179 30426-30433 NN denotes absence
T19180 30434-30436 IN denotes of
T19181 30437-30442 NN denotes Socs2
T19182 30443-30445 CC denotes or
T19183 30446-30450 DT denotes that
T19184 30451-30457 VBZ denotes causes
T19185 30458-30473 JJ denotes transcriptional
T19186 30474-30486 NN denotes deregulation
T19187 30487-30489 IN denotes of
T19188 30490-30492 NN denotes Gh
T19189 30492-30493 . denotes .
T19190 30493-30704 sentence denotes Additionally, functional variation in Stat5b may explain the sex-specific phenotypes in HG11 mice since it is the primary transcription factor responsible for Gh induced sex-specific liver gene expression [44].
T19191 30494-30506 RB denotes Additionally
T19193 30506-30508 , denotes ,
T19194 30508-30518 JJ denotes functional
T19195 30519-30528 NN denotes variation
T19196 30529-30531 IN denotes in
T19197 30532-30538 NN denotes Stat5b
T19198 30539-30542 MD denotes may
T19192 30543-30550 VB denotes explain
T19199 30551-30554 DT denotes the
T19201 30555-30558 NN denotes sex
T19203 30558-30559 HYPH denotes -
T19202 30559-30567 JJ denotes specific
T19200 30568-30578 NNS denotes phenotypes
T19204 30579-30581 IN denotes in
T19205 30582-30586 NN denotes HG11
T19206 30587-30591 NNS denotes mice
T19207 30592-30597 IN denotes since
T19209 30598-30600 PRP denotes it
T19208 30601-30603 VBZ denotes is
T19210 30604-30607 DT denotes the
T19212 30608-30615 JJ denotes primary
T19213 30616-30629 NN denotes transcription
T19211 30630-30636 NN denotes factor
T19214 30637-30648 JJ denotes responsible
T19215 30649-30652 IN denotes for
T19216 30653-30655 NN denotes Gh
T19217 30656-30663 VBN denotes induced
T19219 30664-30667 NN denotes sex
T19221 30667-30668 HYPH denotes -
T19220 30668-30676 JJ denotes specific
T19222 30677-30682 NN denotes liver
T19223 30683-30687 NN denotes gene
T19218 30688-30698 NN denotes expression
T19224 30699-30700 -LRB- denotes [
T19225 30700-30702 CD denotes 44
T19226 30702-30703 -RRB- denotes ]
T19227 30703-30704 . denotes .
T19228 30704-30873 sentence denotes Future studies aimed at identifying the HG11 QTG, will certainly include a thorough characterization of Gh and Stat5b sequence and expression patterns in congenic mice.
T19229 30705-30711 JJ denotes Future
T19230 30712-30719 NNS denotes studies
T19232 30720-30725 VBN denotes aimed
T19233 30726-30728 IN denotes at
T19234 30729-30740 VBG denotes identifying
T19235 30741-30744 DT denotes the
T19237 30745-30749 NN denotes HG11
T19236 30750-30753 NN denotes QTG
T19238 30753-30755 , denotes ,
T19239 30755-30759 MD denotes will
T19240 30760-30769 RB denotes certainly
T19231 30770-30777 VB denotes include
T19241 30778-30779 DT denotes a
T19243 30780-30788 JJ denotes thorough
T19242 30789-30805 NN denotes characterization
T19244 30806-30808 IN denotes of
T19245 30809-30811 NN denotes Gh
T19247 30812-30815 CC denotes and
T19248 30816-30822 NN denotes Stat5b
T19249 30823-30831 NN denotes sequence
T19250 30832-30835 CC denotes and
T19251 30836-30846 NN denotes expression
T19246 30847-30855 NNS denotes patterns
T19252 30856-30858 IN denotes in
T19253 30859-30867 JJ denotes congenic
T19254 30868-30872 NNS denotes mice
T19255 30872-30873 . denotes .
T19256 30873-30989 sentence denotes The hg modifier QTL located within the HG17 strain had large effects on growth, body length and carcass components.
T19257 30874-30877 DT denotes The
T19259 30878-30880 NN denotes hg
T19260 30881-30889 NN denotes modifier
T19258 30890-30893 NN denotes QTL
T19262 30894-30901 VBN denotes located
T19263 30902-30908 IN denotes within
T19264 30909-30912 DT denotes the
T19266 30913-30917 NN denotes HG17
T19265 30918-30924 NN denotes strain
T19261 30925-30928 VBD denotes had
T19267 30929-30934 JJ denotes large
T19268 30935-30942 NNS denotes effects
T19269 30943-30945 IN denotes on
T19270 30946-30952 NN denotes growth
T19271 30952-30954 , denotes ,
T19272 30954-30958 NN denotes body
T19273 30959-30965 NN denotes length
T19274 30966-30969 CC denotes and
T19275 30970-30977 NN denotes carcass
T19276 30978-30988 NNS denotes components
T19277 30988-30989 . denotes .
T19278 30989-31058 sentence denotes The most intriguing candidate gene located in the congenic is Sstr5.
T19279 30990-30993 DT denotes The
T19281 30994-30998 RBS denotes most
T19282 30999-31009 JJ denotes intriguing
T19283 31010-31019 NN denotes candidate
T19280 31020-31024 NN denotes gene
T19285 31025-31032 VBN denotes located
T19286 31033-31035 IN denotes in
T19287 31036-31039 DT denotes the
T19288 31040-31048 JJ denotes congenic
T19284 31049-31051 VBZ denotes is
T19289 31052-31057 NN denotes Sstr5
T19290 31057-31058 . denotes .
T19291 31058-31171 sentence denotes Somatostatin is a potent inhibitor of Gh and Sstr5 is one of five receptors which mediate these effects [45,46].
T19292 31059-31071 NN denotes Somatostatin
T19293 31072-31074 VBZ denotes is
T19294 31075-31076 DT denotes a
T19296 31077-31083 JJ denotes potent
T19295 31084-31093 NN denotes inhibitor
T19297 31094-31096 IN denotes of
T19298 31097-31099 NN denotes Gh
T19299 31100-31103 CC denotes and
T19300 31104-31109 NN denotes Sstr5
T19301 31110-31112 VBZ denotes is
T19302 31113-31116 CD denotes one
T19303 31117-31119 IN denotes of
T19304 31120-31124 CD denotes five
T19305 31125-31134 NNS denotes receptors
T19306 31135-31140 WDT denotes which
T19307 31141-31148 VBP denotes mediate
T19308 31149-31154 DT denotes these
T19309 31155-31162 NNS denotes effects
T19310 31163-31164 -LRB- denotes [
T19312 31164-31166 CD denotes 45
T19313 31166-31167 , denotes ,
T19311 31167-31169 CD denotes 46
T19314 31169-31170 -RRB- denotes ]
T19315 31170-31171 . denotes .
T19316 31171-31309 sentence denotes Ubiquitous and pancreatic beta cell specific knockout of Sstr5 leads to alterations in insulin secretion and glucose homeostasis [47,48].
T19317 31172-31182 JJ denotes Ubiquitous
T19319 31183-31186 CC denotes and
T19320 31187-31197 JJ denotes pancreatic
T19322 31198-31202 NN denotes beta
T19321 31203-31207 NN denotes cell
T19323 31208-31216 JJ denotes specific
T19318 31217-31225 NN denotes knockout
T19325 31226-31228 IN denotes of
T19326 31229-31234 NN denotes Sstr5
T19324 31235-31240 VBZ denotes leads
T19327 31241-31243 IN denotes to
T19328 31244-31255 NNS denotes alterations
T19329 31256-31258 IN denotes in
T19330 31259-31266 NN denotes insulin
T19331 31267-31276 NN denotes secretion
T19332 31277-31280 CC denotes and
T19333 31281-31288 NN denotes glucose
T19334 31289-31300 NN denotes homeostasis
T19335 31301-31302 -LRB- denotes [
T19337 31302-31304 CD denotes 47
T19338 31304-31305 , denotes ,
T19336 31305-31307 CD denotes 48
T19339 31307-31308 -RRB- denotes ]
T19340 31308-31309 . denotes .
T19341 31309-31431 sentence denotes We sequenced candidate hg modifier genes to complement the characterization of the speed congenics on MMU2, 9, 11 and 17.
T19342 31310-31312 PRP denotes We
T19343 31313-31322 VBD denotes sequenced
T19344 31323-31332 NN denotes candidate
T19346 31333-31335 NN denotes hg
T19347 31336-31344 NN denotes modifier
T19345 31345-31350 NNS denotes genes
T19348 31351-31353 TO denotes to
T19349 31354-31364 VB denotes complement
T19350 31365-31368 DT denotes the
T19351 31369-31385 NN denotes characterization
T19352 31386-31388 IN denotes of
T19353 31389-31392 DT denotes the
T19355 31393-31398 NN denotes speed
T19354 31399-31408 NNS denotes congenics
T19356 31409-31411 IN denotes on
T19357 31412-31415 NN denotes MMU
T19358 31415-31416 CD denotes 2
T19359 31416-31418 , denotes ,
T19360 31418-31419 CD denotes 9
T19361 31419-31421 , denotes ,
T19362 31421-31423 CD denotes 11
T19363 31424-31427 CC denotes and
T19364 31428-31430 CD denotes 17
T19365 31430-31431 . denotes .
T19366 31431-31628 sentence denotes A limited number of studies have identified variation within CAST coding sequence; so sequencing candidates gave us the opportunity to estimate the SNP frequency in coding sequence relative to B6.
T19367 31432-31433 DT denotes A
T19369 31434-31441 JJ denotes limited
T19368 31442-31448 NN denotes number
T19371 31449-31451 IN denotes of
T19372 31452-31459 NNS denotes studies
T19373 31460-31464 VBP denotes have
T19370 31465-31475 VBN denotes identified
T19374 31476-31485 NN denotes variation
T19375 31486-31492 IN denotes within
T19376 31493-31497 NN denotes CAST
T19378 31498-31504 NN denotes coding
T19377 31505-31513 NN denotes sequence
T19379 31513-31514 : denotes ;
T19380 31515-31517 CC denotes so
T19381 31518-31528 VBG denotes sequencing
T19382 31529-31539 NNS denotes candidates
T19383 31540-31544 VBD denotes gave
T19384 31545-31547 PRP denotes us
T19385 31548-31551 DT denotes the
T19386 31552-31563 NN denotes opportunity
T19387 31564-31566 TO denotes to
T19388 31567-31575 VB denotes estimate
T19389 31576-31579 DT denotes the
T19391 31580-31583 NN denotes SNP
T19390 31584-31593 NN denotes frequency
T19392 31594-31596 IN denotes in
T19393 31597-31603 NN denotes coding
T19394 31604-31612 NN denotes sequence
T19395 31613-31621 JJ denotes relative
T19396 31622-31624 IN denotes to
T19397 31625-31627 NN denotes B6
T19398 31627-31628 . denotes .
T19399 31628-31736 sentence denotes This information will be vital to future fine mapping studies, which will include gene expression analysis.
T19400 31629-31633 DT denotes This
T19401 31634-31645 NN denotes information
T19403 31646-31650 MD denotes will
T19402 31651-31653 VB denotes be
T19404 31654-31659 JJ denotes vital
T19405 31660-31662 IN denotes to
T19406 31663-31669 JJ denotes future
T19408 31670-31674 JJ denotes fine
T19409 31675-31682 NN denotes mapping
T19407 31683-31690 NNS denotes studies
T19410 31690-31692 , denotes ,
T19411 31692-31697 WDT denotes which
T19413 31698-31702 MD denotes will
T19412 31703-31710 VB denotes include
T19414 31711-31715 NN denotes gene
T19415 31716-31726 NN denotes expression
T19416 31727-31735 NN denotes analysis
T19417 31735-31736 . denotes .
T19418 31736-31950 sentence denotes The high SNP frequency (0.312%; 295 SNP in 94.492 kbp) in CAST genes may lead to a higher rate of false positives using DNA microarrays or quantitative real-time PCR assays, most of which are based on B6 sequence.
T19419 31737-31740 DT denotes The
T19421 31741-31745 JJ denotes high
T19422 31746-31749 NN denotes SNP
T19420 31750-31759 NN denotes frequency
T19424 31760-31761 -LRB- denotes (
T19426 31761-31766 CD denotes 0.312
T19427 31766-31767 NN denotes %
T19428 31767-31768 : denotes ;
T19429 31769-31772 CD denotes 295
T19425 31773-31776 NN denotes SNP
T19430 31777-31779 IN denotes in
T19431 31780-31786 CD denotes 94.492
T19432 31787-31790 NN denotes kbp
T19433 31790-31791 -RRB- denotes )
T19434 31792-31794 IN denotes in
T19435 31795-31799 NN denotes CAST
T19436 31800-31805 NNS denotes genes
T19437 31806-31809 MD denotes may
T19423 31810-31814 VB denotes lead
T19438 31815-31817 IN denotes to
T19439 31818-31819 DT denotes a
T19441 31820-31826 JJR denotes higher
T19440 31827-31831 NN denotes rate
T19442 31832-31834 IN denotes of
T19443 31835-31840 JJ denotes false
T19444 31841-31850 NNS denotes positives
T19445 31851-31856 VBG denotes using
T19446 31857-31860 NN denotes DNA
T19447 31861-31872 NNS denotes microarrays
T19448 31873-31875 CC denotes or
T19449 31876-31888 JJ denotes quantitative
T19451 31889-31893 JJ denotes real
T19453 31893-31894 HYPH denotes -
T19452 31894-31898 NN denotes time
T19454 31899-31902 NN denotes PCR
T19450 31903-31909 NNS denotes assays
T19455 31909-31911 , denotes ,
T19456 31911-31915 JJS denotes most
T19458 31916-31918 IN denotes of
T19459 31919-31924 WDT denotes which
T19460 31925-31928 VBP denotes are
T19457 31929-31934 VBN denotes based
T19461 31935-31937 IN denotes on
T19462 31938-31940 NN denotes B6
T19463 31941-31949 NN denotes sequence
T19464 31949-31950 . denotes .
T19465 31950-32181 sentence denotes Therefore, these sequence data can be used to guide the development of gene expression assays to confirm differential expression for candidates and suggests that genes identified by downstream experiments should also be sequenced.
T19466 31951-31960 RB denotes Therefore
T19468 31960-31962 , denotes ,
T19469 31962-31967 DT denotes these
T19471 31968-31976 NN denotes sequence
T19470 31977-31981 NNS denotes data
T19472 31982-31985 MD denotes can
T19473 31986-31988 VB denotes be
T19467 31989-31993 VBN denotes used
T19474 31994-31996 TO denotes to
T19475 31997-32002 VB denotes guide
T19476 32003-32006 DT denotes the
T19477 32007-32018 NN denotes development
T19478 32019-32021 IN denotes of
T19479 32022-32026 NN denotes gene
T19480 32027-32037 NN denotes expression
T19481 32038-32044 NNS denotes assays
T19482 32045-32047 TO denotes to
T19483 32048-32055 VB denotes confirm
T19484 32056-32068 JJ denotes differential
T19485 32069-32079 NN denotes expression
T19486 32080-32083 IN denotes for
T19487 32084-32094 NNS denotes candidates
T19488 32095-32098 CC denotes and
T19489 32099-32107 VBZ denotes suggests
T19490 32108-32112 IN denotes that
T19492 32113-32118 NNS denotes genes
T19493 32119-32129 VBN denotes identified
T19494 32130-32132 IN denotes by
T19495 32133-32143 JJ denotes downstream
T19496 32144-32155 NNS denotes experiments
T19497 32156-32162 MD denotes should
T19498 32163-32167 RB denotes also
T19499 32168-32170 VB denotes be
T19491 32171-32180 VBN denotes sequenced
T19500 32180-32181 . denotes .
T19501 32181-32308 sentence denotes More importantly, sequencing hg modifier candidates allowed us to identify nonsynonomous polymorphism, which may underlie QTL.
T19502 32182-32186 RBR denotes More
T19503 32187-32198 RB denotes importantly
T19505 32198-32200 , denotes ,
T19506 32200-32210 VBG denotes sequencing
T19507 32211-32213 NN denotes hg
T19508 32214-32222 NN denotes modifier
T19509 32223-32233 NNS denotes candidates
T19504 32234-32241 VBD denotes allowed
T19510 32242-32244 PRP denotes us
T19512 32245-32247 TO denotes to
T19511 32248-32256 VB denotes identify
T19513 32257-32270 JJ denotes nonsynonomous
T19514 32271-32283 NN denotes polymorphism
T19515 32283-32285 , denotes ,
T19516 32285-32290 WDT denotes which
T19518 32291-32294 MD denotes may
T19517 32295-32303 VB denotes underlie
T19519 32304-32307 NN denotes QTL
T19520 32307-32308 . denotes .
T19521 32308-32453 sentence denotes SIFT and/or PolyPhen predicted alterations in protein function for 15 of the 56 total nsSNP (27%) in nine of the 44 total genes (20%) (Table 7).
T19522 32309-32313 NNP denotes SIFT
T19524 32314-32317 CC denotes and
T19525 32317-32318 HYPH denotes /
T19526 32318-32320 CC denotes or
T19527 32321-32329 NNP denotes PolyPhen
T19523 32330-32339 VBN denotes predicted
T19528 32340-32351 NNS denotes alterations
T19529 32352-32354 IN denotes in
T19530 32355-32362 NN denotes protein
T19531 32363-32371 NN denotes function
T19532 32372-32375 IN denotes for
T19533 32376-32378 CD denotes 15
T19534 32379-32381 IN denotes of
T19535 32382-32385 DT denotes the
T19537 32386-32388 CD denotes 56
T19538 32389-32394 JJ denotes total
T19536 32395-32400 NN denotes nsSNP
T19539 32401-32402 -LRB- denotes (
T19541 32402-32404 CD denotes 27
T19540 32404-32405 NN denotes %
T19542 32405-32406 -RRB- denotes )
T19543 32407-32409 IN denotes in
T19544 32410-32414 CD denotes nine
T19545 32415-32417 IN denotes of
T19546 32418-32421 DT denotes the
T19548 32422-32424 CD denotes 44
T19549 32425-32430 JJ denotes total
T19547 32431-32436 NNS denotes genes
T19550 32437-32438 -LRB- denotes (
T19552 32438-32440 CD denotes 20
T19551 32440-32441 NN denotes %
T19553 32441-32442 -RRB- denotes )
T19554 32443-32444 -LRB- denotes (
T19555 32444-32449 NN denotes Table
T19556 32450-32451 CD denotes 7
T19557 32451-32452 -RRB- denotes )
T19558 32452-32453 . denotes .
T19559 32453-32595 sentence denotes It has been shown that predicting function based on evolutionary conservation using programs such as SIFT and PolyPhen is very accurate [49].
T19560 32454-32456 PRP denotes It
T19562 32457-32460 VBZ denotes has
T19563 32461-32465 VBN denotes been
T19561 32466-32471 VBN denotes shown
T19564 32472-32476 IN denotes that
T19566 32477-32487 VBG denotes predicting
T19567 32488-32496 NN denotes function
T19568 32497-32502 VBN denotes based
T19569 32503-32505 IN denotes on
T19570 32506-32518 JJ denotes evolutionary
T19571 32519-32531 NN denotes conservation
T19572 32532-32537 VBG denotes using
T19573 32538-32546 NNS denotes programs
T19574 32547-32551 JJ denotes such
T19575 32552-32554 IN denotes as
T19576 32555-32559 NNP denotes SIFT
T19577 32560-32563 CC denotes and
T19578 32564-32572 NNP denotes PolyPhen
T19565 32573-32575 VBZ denotes is
T19579 32576-32580 RB denotes very
T19580 32581-32589 JJ denotes accurate
T19581 32590-32591 -LRB- denotes [
T19582 32591-32593 CD denotes 49
T19583 32593-32594 -RRB- denotes ]
T19584 32594-32595 . denotes .
T19585 32595-32706 sentence denotes Four of the nine genes (Ubr1, Ptpns1, Ubce7ip5 and Mmp9; all of which are on MMU2) are of particular interest.
T19586 32596-32600 CD denotes Four
T19588 32601-32603 IN denotes of
T19589 32604-32607 DT denotes the
T19591 32608-32612 CD denotes nine
T19590 32613-32618 NNS denotes genes
T19592 32619-32620 -LRB- denotes (
T19593 32620-32624 NN denotes Ubr1
T19594 32624-32626 , denotes ,
T19595 32626-32632 NN denotes Ptpns1
T19596 32632-32634 , denotes ,
T19597 32634-32642 NN denotes Ubce7ip5
T19598 32643-32646 CC denotes and
T19599 32647-32651 NN denotes Mmp9
T19600 32651-32652 : denotes ;
T19601 32653-32656 DT denotes all
T19603 32657-32659 IN denotes of
T19604 32660-32665 WDT denotes which
T19602 32666-32669 VBP denotes are
T19605 32670-32672 IN denotes on
T19606 32673-32677 NN denotes MMU2
T19607 32677-32678 -RRB- denotes )
T19587 32679-32682 VBP denotes are
T19608 32683-32685 IN denotes of
T19609 32686-32696 JJ denotes particular
T19610 32697-32705 NN denotes interest
T19611 32705-32706 . denotes .
T19612 32706-32829 sentence denotes It has been suggested the Socs2 may rely on ubiquitination dependent proteasomal degradation to inhibit Gh signaling [23].
T19613 32707-32709 PRP denotes It
T19615 32710-32713 VBZ denotes has
T19616 32714-32718 VBN denotes been
T19614 32719-32728 VBN denotes suggested
T19617 32729-32732 DT denotes the
T19618 32733-32738 NN denotes Socs2
T19620 32739-32742 MD denotes may
T19619 32743-32747 VB denotes rely
T19621 32748-32750 IN denotes on
T19622 32751-32765 NN denotes ubiquitination
T19623 32766-32775 JJ denotes dependent
T19625 32776-32787 JJ denotes proteasomal
T19624 32788-32799 NN denotes degradation
T19626 32800-32802 TO denotes to
T19627 32803-32810 VB denotes inhibit
T19628 32811-32813 NN denotes Gh
T19629 32814-32823 NN denotes signaling
T19630 32824-32825 -LRB- denotes [
T19631 32825-32827 CD denotes 23
T19632 32827-32828 -RRB- denotes ]
T19633 32828-32829 . denotes .
T19634 32829-33003 sentence denotes Ubr1 and Ubce7ip5 are both involved in protein ubiquitination and Ubr1 knockout mice show an 20% decrease in body weight partly due to a reduction in adipose tissue [50,51].
T19635 32830-32834 NN denotes Ubr1
T19637 32835-32838 CC denotes and
T19638 32839-32847 NN denotes Ubce7ip5
T19639 32848-32851 VBP denotes are
T19640 32852-32856 RB denotes both
T19636 32857-32865 VBN denotes involved
T19641 32866-32868 IN denotes in
T19642 32869-32876 NN denotes protein
T19643 32877-32891 NN denotes ubiquitination
T19644 32892-32895 CC denotes and
T19645 32896-32900 NN denotes Ubr1
T19646 32901-32909 NN denotes knockout
T19647 32910-32914 NNS denotes mice
T19648 32915-32919 VBP denotes show
T19649 32920-32922 DT denotes an
T19651 32923-32925 CD denotes 20
T19652 32925-32926 NN denotes %
T19650 32927-32935 NN denotes decrease
T19653 32936-32938 IN denotes in
T19654 32939-32943 NN denotes body
T19655 32944-32950 NN denotes weight
T19656 32951-32957 RB denotes partly
T19657 32958-32961 IN denotes due
T19658 32962-32964 IN denotes to
T19659 32965-32966 DT denotes a
T19660 32967-32976 NN denotes reduction
T19661 32977-32979 IN denotes in
T19662 32980-32987 NN denotes adipose
T19663 32988-32994 NN denotes tissue
T19664 32995-32996 -LRB- denotes [
T19666 32996-32998 CD denotes 50
T19667 32998-32999 , denotes ,
T19665 32999-33001 CD denotes 51
T19668 33001-33002 -RRB- denotes ]
T19669 33002-33003 . denotes .
T19670 33003-33160 sentence denotes Ptpns1 knockout mice displayed a 10% reduction in body weight [52] and Mmp9 knockout mice show a reduction in size and drastically reduced bone length [53].
T19671 33004-33010 NN denotes Ptpns1
T19673 33011-33019 NN denotes knockout
T19672 33020-33024 NNS denotes mice
T19674 33025-33034 VBD denotes displayed
T19675 33035-33036 DT denotes a
T19677 33037-33039 CD denotes 10
T19678 33039-33040 NN denotes %
T19676 33041-33050 NN denotes reduction
T19679 33051-33053 IN denotes in
T19680 33054-33058 NN denotes body
T19681 33059-33065 NN denotes weight
T19682 33066-33067 -LRB- denotes [
T19683 33067-33069 CD denotes 52
T19684 33069-33070 -RRB- denotes ]
T19685 33071-33074 CC denotes and
T19686 33075-33079 NN denotes Mmp9
T19688 33080-33088 NN denotes knockout
T19687 33089-33093 NNS denotes mice
T19689 33094-33098 VBP denotes show
T19690 33099-33100 DT denotes a
T19691 33101-33110 NN denotes reduction
T19692 33111-33113 IN denotes in
T19693 33114-33118 NN denotes size
T19694 33119-33122 CC denotes and
T19695 33123-33134 RB denotes drastically
T19696 33135-33142 VBN denotes reduced
T19698 33143-33147 NN denotes bone
T19697 33148-33154 NN denotes length
T19699 33155-33156 -LRB- denotes [
T19700 33156-33158 CD denotes 53
T19701 33158-33159 -RRB- denotes ]
T19702 33159-33160 . denotes .
T19703 33160-33322 sentence denotes All of these genes are excellent functional and positional hg modifier candidate genes and this information can be incorporated into future fine mapping studies.
T19704 33161-33164 DT denotes All
T19706 33165-33167 IN denotes of
T19707 33168-33173 DT denotes these
T19708 33174-33179 NNS denotes genes
T19705 33180-33183 VBP denotes are
T19709 33184-33193 JJ denotes excellent
T19711 33194-33204 JJ denotes functional
T19712 33205-33208 CC denotes and
T19713 33209-33219 JJ denotes positional
T19714 33220-33222 NN denotes hg
T19715 33223-33231 NN denotes modifier
T19716 33232-33241 NN denotes candidate
T19710 33242-33247 NNS denotes genes
T19717 33248-33251 CC denotes and
T19718 33252-33256 DT denotes this
T19719 33257-33268 NN denotes information
T19721 33269-33272 MD denotes can
T19722 33273-33275 VB denotes be
T19720 33276-33288 VBN denotes incorporated
T19723 33289-33293 IN denotes into
T19724 33294-33300 JJ denotes future
T19726 33301-33305 JJ denotes fine
T19727 33306-33313 NN denotes mapping
T19725 33314-33321 NNS denotes studies
T19728 33321-33322 . denotes .
T19896 33335-33338 DT denotes The
T19898 33339-33344 NN denotes speed
T19899 33345-33353 JJ denotes congenic
T19897 33354-33361 NNS denotes strains
T19901 33362-33371 VBN denotes developed
T19902 33372-33378 RB denotes herein
T19900 33379-33386 VBP denotes confirm
T19903 33387-33397 RB denotes previously
T19904 33398-33408 VBN denotes identified
T19906 33409-33415 NN denotes genome
T19908 33415-33416 HYPH denotes -
T19907 33416-33420 JJ denotes wide
T19905 33421-33424 NN denotes QTL
T19909 33425-33434 VBG denotes affecting
T19910 33435-33441 NN denotes growth
T19911 33441-33443 , denotes ,
T19912 33443-33450 NN denotes obesity
T19913 33451-33454 CC denotes and
T19914 33455-33462 NN denotes carcass
T19915 33463-33474 NN denotes composition
T19916 33474-33475 . denotes .
T19917 33475-33634 sentence denotes Our novel congenic development approach on MMU2 provided confirmation of QTL-hg interactions, which will significantly aid in future fine mapping experiments.
T19918 33476-33479 PRP$ denotes Our
T19920 33480-33485 JJ denotes novel
T19921 33486-33494 JJ denotes congenic
T19922 33495-33506 NN denotes development
T19919 33507-33515 NN denotes approach
T19924 33516-33518 IN denotes on
T19925 33519-33523 NN denotes MMU2
T19923 33524-33532 VBD denotes provided
T19926 33533-33545 NN denotes confirmation
T19927 33546-33548 IN denotes of
T19928 33549-33552 NN denotes QTL
T19930 33552-33553 HYPH denotes -
T19929 33553-33555 NN denotes hg
T19931 33556-33568 NNS denotes interactions
T19932 33568-33570 , denotes ,
T19933 33570-33575 WDT denotes which
T19935 33576-33580 MD denotes will
T19936 33581-33594 RB denotes significantly
T19934 33595-33598 VB denotes aid
T19937 33599-33601 IN denotes in
T19938 33602-33608 JJ denotes future
T19940 33609-33613 JJ denotes fine
T19941 33614-33621 NN denotes mapping
T19939 33622-33633 NNS denotes experiments
T19942 33633-33634 . denotes .
T19943 33634-33843 sentence denotes The identification of the molecular mediators of QTL-hg epistasis as well as the QTG for the remaining congenics will provide essential information on the molecular genetic architecture of growth and obesity.
T19944 33635-33638 DT denotes The
T19945 33639-33653 NN denotes identification
T19947 33654-33656 IN denotes of
T19948 33657-33660 DT denotes the
T19950 33661-33670 JJ denotes molecular
T19949 33671-33680 NNS denotes mediators
T19951 33681-33683 IN denotes of
T19952 33684-33687 NN denotes QTL
T19954 33687-33688 HYPH denotes -
T19953 33688-33690 NN denotes hg
T19955 33691-33700 NN denotes epistasis
T19956 33701-33703 RB denotes as
T19958 33704-33708 RB denotes well
T19957 33709-33711 IN denotes as
T19959 33712-33715 DT denotes the
T19960 33716-33719 NN denotes QTG
T19961 33720-33723 IN denotes for
T19962 33724-33727 DT denotes the
T19964 33728-33737 VBG denotes remaining
T19963 33738-33747 NNS denotes congenics
T19965 33748-33752 MD denotes will
T19946 33753-33760 VB denotes provide
T19966 33761-33770 JJ denotes essential
T19967 33771-33782 NN denotes information
T19968 33783-33785 IN denotes on
T19969 33786-33789 DT denotes the
T19971 33790-33799 JJ denotes molecular
T19972 33800-33807 JJ denotes genetic
T19970 33808-33820 NN denotes architecture
T19973 33821-33823 IN denotes of
T19974 33824-33830 NN denotes growth
T19975 33831-33834 CC denotes and
T19976 33835-33842 NN denotes obesity
T19977 33842-33843 . denotes .
T20228 33854-33859 NN denotes Mouse
T20229 33860-33867 NNS denotes strains
T20230 33868-33871 CC denotes and
T20231 33872-33881 JJ denotes husbandry
T20232 33881-33955 sentence denotes CAST/EiJ (stock #000928) mice were purchased from the Jackson Laboratory.
T20233 33882-33886 NN denotes CAST
T20235 33886-33887 HYPH denotes /
T20234 33887-33890 NN denotes EiJ
T20237 33891-33892 -LRB- denotes (
T20239 33892-33897 NN denotes stock
T20238 33898-33899 NN denotes #
T20240 33899-33905 CD denotes 000928
T20241 33905-33906 -RRB- denotes )
T20236 33907-33911 NNS denotes mice
T20243 33912-33916 VBD denotes were
T20242 33917-33926 VBN denotes purchased
T20244 33927-33931 IN denotes from
T20245 33932-33935 DT denotes the
T20247 33936-33943 NNP denotes Jackson
T20246 33944-33954 NNP denotes Laboratory
T20248 33954-33955 . denotes .
T20249 33955-34123 sentence denotes The hg mutation was originally identified in a selected outcross line [22] and has been introgressed onto a B6 background via nine backcrosses to create the HG strain.
T20250 33956-33959 DT denotes The
T20252 33960-33962 NN denotes hg
T20251 33963-33971 NN denotes mutation
T20254 33972-33975 VBD denotes was
T20255 33976-33986 RB denotes originally
T20253 33987-33997 VBN denotes identified
T20256 33998-34000 IN denotes in
T20257 34001-34002 DT denotes a
T20259 34003-34011 VBN denotes selected
T20260 34012-34020 NN denotes outcross
T20258 34021-34025 NN denotes line
T20261 34026-34027 -LRB- denotes [
T20262 34027-34029 CD denotes 22
T20263 34029-34030 -RRB- denotes ]
T20264 34031-34034 CC denotes and
T20265 34035-34038 VBZ denotes has
T20267 34039-34043 VBN denotes been
T20266 34044-34056 VBN denotes introgressed
T20268 34057-34061 IN denotes onto
T20269 34062-34063 DT denotes a
T20271 34064-34066 NN denotes B6
T20270 34067-34077 NN denotes background
T20272 34078-34081 IN denotes via
T20273 34082-34086 CD denotes nine
T20274 34087-34098 NNS denotes backcrosses
T20275 34099-34101 TO denotes to
T20276 34102-34108 VB denotes create
T20277 34109-34112 DT denotes the
T20279 34113-34115 NN denotes HG
T20278 34116-34122 NN denotes strain
T20280 34122-34123 . denotes .
T20281 34123-34209 sentence denotes HG mice used in this experiment were from the 17th or later generation of inbreeding.
T20282 34124-34126 NN denotes HG
T20283 34127-34131 NNS denotes mice
T20285 34132-34136 VBN denotes used
T20286 34137-34139 IN denotes in
T20287 34140-34144 DT denotes this
T20288 34145-34155 NN denotes experiment
T20284 34156-34160 VBD denotes were
T20289 34161-34165 IN denotes from
T20290 34166-34169 DT denotes the
T20292 34170-34174 JJ denotes 17th
T20293 34175-34177 CC denotes or
T20294 34178-34183 JJ denotes later
T20291 34184-34194 NN denotes generation
T20295 34195-34197 IN denotes of
T20296 34198-34208 NN denotes inbreeding
T20297 34208-34209 . denotes .
T20298 34209-34503 sentence denotes Mice were housed in polycarbonate cages under controlled conditions of temperature (21°C ± 2°C), humidity (40–70%) and lighting (14 h light, 10 h dark, lights on at 7 AM), and managed according to the guidelines of the American Association for Accreditation of Laboratory Animal Care (AAALAC).
T20299 34210-34214 NNS denotes Mice
T20301 34215-34219 VBD denotes were
T20300 34220-34226 VBN denotes housed
T20302 34227-34229 IN denotes in
T20303 34230-34243 NN denotes polycarbonate
T20304 34244-34249 NNS denotes cages
T20305 34250-34255 IN denotes under
T20306 34256-34266 VBN denotes controlled
T20307 34267-34277 NNS denotes conditions
T20308 34278-34280 IN denotes of
T20309 34281-34292 NN denotes temperature
T20310 34293-34294 -LRB- denotes (
T20312 34294-34296 CD denotes 21
T20311 34296-34298 NN denotes °C
T20313 34299-34300 SYM denotes ±
T20314 34301-34302 CD denotes 2
T20315 34302-34304 NN denotes °C
T20316 34304-34305 -RRB- denotes )
T20317 34305-34307 , denotes ,
T20318 34307-34315 NN denotes humidity
T20319 34316-34317 -LRB- denotes (
T20321 34317-34319 CD denotes 40
T20323 34319-34320 SYM denotes –
T20322 34320-34322 CD denotes 70
T20320 34322-34323 NN denotes %
T20324 34323-34324 -RRB- denotes )
T20325 34325-34328 CC denotes and
T20326 34329-34337 NN denotes lighting
T20327 34338-34339 -LRB- denotes (
T20329 34339-34341 CD denotes 14
T20330 34342-34343 NN denotes h
T20331 34344-34349 NN denotes light
T20332 34349-34351 , denotes ,
T20333 34351-34353 CD denotes 10
T20334 34354-34355 NN denotes h
T20328 34356-34360 NN denotes dark
T20335 34360-34362 , denotes ,
T20336 34362-34368 NNS denotes lights
T20337 34369-34371 RB denotes on
T20338 34372-34374 IN denotes at
T20339 34375-34376 CD denotes 7
T20340 34377-34379 NN denotes AM
T20341 34379-34380 -RRB- denotes )
T20342 34380-34382 , denotes ,
T20343 34382-34385 CC denotes and
T20344 34386-34393 VBD denotes managed
T20345 34394-34403 VBG denotes according
T20346 34404-34406 IN denotes to
T20347 34407-34410 DT denotes the
T20348 34411-34421 NNS denotes guidelines
T20349 34422-34424 IN denotes of
T20350 34425-34428 DT denotes the
T20352 34429-34437 NNP denotes American
T20351 34438-34449 NNP denotes Association
T20353 34450-34453 IN denotes for
T20354 34454-34467 NNP denotes Accreditation
T20355 34468-34470 IN denotes of
T20356 34471-34481 NNP denotes Laboratory
T20357 34482-34488 NNP denotes Animal
T20358 34489-34493 NNP denotes Care
T20359 34494-34495 -LRB- denotes (
T20360 34495-34501 NNP denotes AAALAC
T20361 34501-34502 -RRB- denotes )
T20362 34502-34503 . denotes .
T20779 34505-34515 NN denotes Genotyping
T20780 34515-34719 sentence denotes DNA for genotyping was isolated from 1.0–2.0 mm tail clips by digesting with Proteinase K (Fisher) at 55°C in a buffer composed of 0.45% NP40 (Sigma), 0.45% Tween 20 (Fisher) and 1X PCR buffer (Promega).
T20781 34516-34519 NN denotes DNA
T20783 34520-34523 IN denotes for
T20784 34524-34534 NN denotes genotyping
T20785 34535-34538 VBD denotes was
T20782 34539-34547 VBN denotes isolated
T20786 34548-34552 IN denotes from
T20787 34553-34556 CD denotes 1.0
T20789 34556-34557 SYM denotes –
T20788 34557-34560 CD denotes 2.0
T20790 34561-34563 NN denotes mm
T20792 34564-34568 NN denotes tail
T20791 34569-34574 NNS denotes clips
T20793 34575-34577 IN denotes by
T20794 34578-34587 VBG denotes digesting
T20795 34588-34592 IN denotes with
T20796 34593-34603 NN denotes Proteinase
T20797 34604-34605 NN denotes K
T20798 34606-34607 -LRB- denotes (
T20799 34607-34613 NNP denotes Fisher
T20800 34613-34614 -RRB- denotes )
T20801 34615-34617 IN denotes at
T20802 34618-34620 CD denotes 55
T20803 34620-34622 NN denotes °C
T20804 34623-34625 IN denotes in
T20805 34626-34627 DT denotes a
T20806 34628-34634 NN denotes buffer
T20807 34635-34643 VBN denotes composed
T20808 34644-34646 IN denotes of
T20809 34647-34651 CD denotes 0.45
T20810 34651-34652 NN denotes %
T20811 34653-34657 NN denotes NP40
T20812 34658-34659 -LRB- denotes (
T20813 34659-34664 NNP denotes Sigma
T20814 34664-34665 -RRB- denotes )
T20815 34665-34667 , denotes ,
T20816 34667-34671 CD denotes 0.45
T20817 34671-34672 NN denotes %
T20818 34673-34678 NN denotes Tween
T20819 34679-34681 CD denotes 20
T20820 34682-34683 -LRB- denotes (
T20821 34683-34689 NNP denotes Fisher
T20822 34689-34690 -RRB- denotes )
T20823 34691-34694 CC denotes and
T20824 34695-34697 NN denotes 1X
T20826 34698-34701 NN denotes PCR
T20825 34702-34708 NN denotes buffer
T20827 34709-34710 -LRB- denotes (
T20828 34710-34717 NNP denotes Promega
T20829 34717-34718 -RRB- denotes )
T20830 34718-34719 . denotes .
T20831 34719-34837 sentence denotes The product of this digestion was diluted (1:10) in sterile H2O and used for genotyping without further purification.
T20832 34720-34723 DT denotes The
T20833 34724-34731 NN denotes product
T20835 34732-34734 IN denotes of
T20836 34735-34739 DT denotes this
T20837 34740-34749 NN denotes digestion
T20838 34750-34753 VBD denotes was
T20834 34754-34761 VBN denotes diluted
T20839 34762-34763 -LRB- denotes (
T20840 34763-34764 CD denotes 1
T20841 34764-34765 SYM denotes :
T20842 34765-34767 CD denotes 10
T20843 34767-34768 -RRB- denotes )
T20844 34769-34771 IN denotes in
T20845 34772-34779 JJ denotes sterile
T20846 34780-34783 NN denotes H2O
T20847 34784-34787 CC denotes and
T20848 34788-34792 VBN denotes used
T20849 34793-34796 IN denotes for
T20850 34797-34807 NN denotes genotyping
T20851 34808-34815 IN denotes without
T20852 34816-34823 JJ denotes further
T20853 34824-34836 NN denotes purification
T20854 34836-34837 . denotes .
T20855 34837-34931 sentence denotes Microsatellite genotyping was performed using standard PCR and gel electrophoresis protocols.
T20856 34838-34852 NN denotes Microsatellite
T20857 34853-34863 NN denotes genotyping
T20859 34864-34867 VBD denotes was
T20858 34868-34877 VBN denotes performed
T20860 34878-34883 VBG denotes using
T20861 34884-34892 JJ denotes standard
T20863 34893-34896 NN denotes PCR
T20864 34897-34900 CC denotes and
T20865 34901-34904 NN denotes gel
T20866 34905-34920 NN denotes electrophoresis
T20862 34921-34930 NNS denotes protocols
T20867 34930-34931 . denotes .
T20868 34931-35006 sentence denotes Reaction conditions for each marker are listed in Additional File 1 and 2.
T20869 34932-34940 NN denotes Reaction
T20870 34941-34951 NNS denotes conditions
T20872 34952-34955 IN denotes for
T20873 34956-34960 DT denotes each
T20874 34961-34967 NN denotes marker
T20875 34968-34971 VBP denotes are
T20871 34972-34978 VBN denotes listed
T20876 34979-34981 IN denotes in
T20877 34982-34992 JJ denotes Additional
T20879 34993-34997 NN denotes File
T20878 34998-34999 CD denotes 1
T20880 35000-35003 CC denotes and
T20881 35004-35005 CD denotes 2
T20882 35005-35006 . denotes .
T20883 35006-35084 sentence denotes MMU2 congenic mice were genotyped for hg using a two primer genotyping assay.
T20884 35007-35011 NN denotes MMU2
T20885 35012-35020 JJ denotes congenic
T20886 35021-35025 NNS denotes mice
T20888 35026-35030 VBD denotes were
T20887 35031-35040 VBN denotes genotyped
T20889 35041-35044 IN denotes for
T20890 35045-35047 NN denotes hg
T20891 35048-35053 VBG denotes using
T20892 35054-35055 DT denotes a
T20894 35056-35059 CD denotes two
T20895 35060-35066 NN denotes primer
T20896 35067-35077 NN denotes genotyping
T20893 35078-35083 NN denotes assay
T20897 35083-35084 . denotes .
T20898 35084-35233 sentence denotes One primer set (HG-F, ctcctgtctgggctgtgag and HG-R, caaaggcagaagtggggtaa) spanned the hg deletion producing a 447 bp product in hg/hg and +/hg mice.
T20899 35085-35088 CD denotes One
T20901 35089-35095 NN denotes primer
T20900 35096-35099 NN denotes set
T20903 35100-35101 -LRB- denotes (
T20904 35101-35103 NN denotes HG
T20906 35103-35104 HYPH denotes -
T20905 35104-35105 NN denotes F
T20907 35105-35107 , denotes ,
T20908 35107-35126 NN denotes ctcctgtctgggctgtgag
T20909 35127-35130 CC denotes and
T20910 35131-35133 NN denotes HG
T20912 35133-35134 HYPH denotes -
T20911 35134-35135 NN denotes R
T20913 35135-35137 , denotes ,
T20914 35137-35157 NN denotes caaaggcagaagtggggtaa
T20915 35157-35158 -RRB- denotes )
T20902 35159-35166 VBD denotes spanned
T20916 35167-35170 DT denotes the
T20918 35171-35173 NN denotes hg
T20917 35174-35182 NN denotes deletion
T20919 35183-35192 VBG denotes producing
T20920 35193-35194 DT denotes a
T20922 35195-35198 CD denotes 447
T20923 35199-35201 NN denotes bp
T20921 35202-35209 NN denotes product
T20924 35210-35212 IN denotes in
T20925 35213-35215 NN denotes hg
T20927 35215-35216 HYPH denotes /
T20926 35216-35218 NN denotes hg
T20929 35219-35222 CC denotes and
T20930 35223-35224 SYM denotes +
T20932 35224-35225 HYPH denotes /
T20931 35225-35227 NN denotes hg
T20928 35228-35232 NNS denotes mice
T20933 35232-35233 . denotes .
T20934 35233-35410 sentence denotes The other set (CRADD3a.F, gtccatcagcattcctgaaa and CRADD3.R, tgtccagcaacagcattgtc) amplified a 232 bp Cradd amplicon (located within the hg deletion) in +/+ and +/hg mice [54].
T20935 35234-35237 DT denotes The
T20937 35238-35243 JJ denotes other
T20936 35244-35247 NN denotes set
T20939 35248-35249 -LRB- denotes (
T20940 35249-35258 NN denotes CRADD3a.F
T20941 35258-35260 , denotes ,
T20942 35260-35280 NN denotes gtccatcagcattcctgaaa
T20943 35281-35284 CC denotes and
T20944 35285-35293 NN denotes CRADD3.R
T20945 35293-35295 , denotes ,
T20946 35295-35315 NN denotes tgtccagcaacagcattgtc
T20947 35315-35316 -RRB- denotes )
T20938 35317-35326 VBD denotes amplified
T20948 35327-35328 DT denotes a
T20950 35329-35332 CD denotes 232
T20951 35333-35335 NN denotes bp
T20952 35336-35341 NN denotes Cradd
T20949 35342-35350 NN denotes amplicon
T20953 35351-35352 -LRB- denotes (
T20954 35352-35359 VBN denotes located
T20955 35360-35366 IN denotes within
T20956 35367-35370 DT denotes the
T20958 35371-35373 NN denotes hg
T20957 35374-35382 NN denotes deletion
T20959 35382-35383 -RRB- denotes )
T20960 35384-35386 IN denotes in
T20961 35387-35388 SYM denotes +
T20963 35388-35389 HYPH denotes /
T20962 35389-35390 SYM denotes +
T20965 35391-35394 CC denotes and
T20966 35395-35396 SYM denotes +
T20968 35396-35397 HYPH denotes /
T20967 35397-35399 NN denotes hg
T20964 35400-35404 NNS denotes mice
T20969 35405-35406 -LRB- denotes [
T20970 35406-35408 CD denotes 54
T20971 35408-35409 -RRB- denotes ]
T20972 35409-35410 . denotes .
T20973 35410-35489 sentence denotes The PCR annealing temperature was 55°C and the MgCl2 concentration was 1.5 mM.
T20974 35411-35414 DT denotes The
T20976 35415-35418 NN denotes PCR
T20977 35419-35428 VBG denotes annealing
T20975 35429-35440 NN denotes temperature
T20978 35441-35444 VBD denotes was
T20979 35445-35447 CD denotes 55
T20980 35447-35449 NN denotes °C
T20981 35450-35453 CC denotes and
T20982 35454-35457 DT denotes the
T20984 35458-35463 NN denotes MgCl2
T20983 35464-35477 NN denotes concentration
T20985 35478-35481 VBD denotes was
T20986 35482-35485 CD denotes 1.5
T20987 35486-35488 NN denotes mM
T20988 35488-35489 . denotes .
T21607 35491-35502 NN denotes Development
T21608 35503-35505 IN denotes of
T21609 35506-35513 NN denotes B6.CAST
T21611 35514-35517 CC denotes and
T21612 35518-35525 NN denotes HG.CAST
T21610 35526-35530 NN denotes MMU2
T21614 35531-35536 NN denotes speed
T21615 35537-35545 JJ denotes congenic
T21613 35546-35553 NNS denotes strains
T21616 35553-35679 sentence denotes All speed congenic strains were developed starting with an initial cross between a CAST male and HG females (Figure 1) [5,6].
T21617 35554-35557 DT denotes All
T21619 35558-35563 NN denotes speed
T21620 35564-35572 JJ denotes congenic
T21618 35573-35580 NNS denotes strains
T21622 35581-35585 VBD denotes were
T21621 35586-35595 VBN denotes developed
T21623 35596-35604 VBG denotes starting
T21624 35605-35609 IN denotes with
T21625 35610-35612 DT denotes an
T21627 35613-35620 JJ denotes initial
T21626 35621-35626 NN denotes cross
T21628 35627-35634 IN denotes between
T21629 35635-35636 DT denotes a
T21631 35637-35641 NN denotes CAST
T21630 35642-35646 NN denotes male
T21632 35647-35650 CC denotes and
T21633 35651-35653 NN denotes HG
T21634 35654-35661 NNS denotes females
T21635 35662-35663 -LRB- denotes (
T21636 35663-35669 NN denotes Figure
T21637 35670-35671 CD denotes 1
T21638 35671-35672 -RRB- denotes )
T21639 35673-35674 -LRB- denotes [
T21641 35674-35675 CD denotes 5
T21642 35675-35676 , denotes ,
T21640 35676-35677 CD denotes 6
T21643 35677-35678 -RRB- denotes ]
T21644 35678-35679 . denotes .
T21645 35679-35729 sentence denotes Male F1 mice were then backcrossed to HG females.
T21646 35680-35684 JJ denotes Male
T21648 35685-35687 NN denotes F1
T21647 35688-35692 NNS denotes mice
T21650 35693-35697 VBD denotes were
T21651 35698-35702 RB denotes then
T21649 35703-35714 VBN denotes backcrossed
T21652 35715-35717 IN denotes to
T21653 35718-35720 NN denotes HG
T21654 35721-35728 NNS denotes females
T21655 35728-35729 . denotes .
T21656 35729-35882 sentence denotes All agouti (the dominant nonagouti (a) locus is located at 154.8 Mbp on MMU2) N2 males were genotyped for 79 microsatellite markers (Additional File 1).
T21657 35730-35733 DT denotes All
T21659 35734-35740 NN denotes agouti
T21660 35741-35742 -LRB- denotes (
T21662 35742-35745 DT denotes the
T21664 35746-35754 JJ denotes dominant
T21665 35755-35764 JJ denotes nonagouti
T21667 35765-35766 -LRB- denotes (
T21666 35766-35767 NN denotes a
T21668 35767-35768 -RRB- denotes )
T21663 35769-35774 NN denotes locus
T21669 35775-35777 VBZ denotes is
T21661 35778-35785 VBN denotes located
T21670 35786-35788 IN denotes at
T21671 35789-35794 CD denotes 154.8
T21672 35795-35798 NN denotes Mbp
T21673 35799-35801 IN denotes on
T21674 35802-35806 NN denotes MMU2
T21675 35806-35807 -RRB- denotes )
T21676 35808-35810 NN denotes N2
T21658 35811-35816 NNS denotes males
T21678 35817-35821 VBD denotes were
T21677 35822-35831 VBN denotes genotyped
T21679 35832-35835 IN denotes for
T21680 35836-35838 CD denotes 79
T21682 35839-35853 NN denotes microsatellite
T21681 35854-35861 NNS denotes markers
T21683 35862-35863 -LRB- denotes (
T21685 35863-35873 JJ denotes Additional
T21684 35874-35878 NN denotes File
T21686 35879-35880 CD denotes 1
T21687 35880-35881 -RRB- denotes )
T21688 35881-35882 . denotes .
T21689 35882-36030 sentence denotes These markers were evenly spaced across the genome, except in regions previously identified as harboring QTL [1], which were more densely screened.
T21690 35883-35888 DT denotes These
T21691 35889-35896 NNS denotes markers
T21693 35897-35901 VBD denotes were
T21694 35902-35908 RB denotes evenly
T21692 35909-35915 VBN denotes spaced
T21695 35916-35922 IN denotes across
T21696 35923-35926 DT denotes the
T21697 35927-35933 NN denotes genome
T21698 35933-35935 , denotes ,
T21699 35935-35941 RB denotes except
T21700 35942-35944 IN denotes in
T21701 35945-35952 NNS denotes regions
T21702 35953-35963 RB denotes previously
T21703 35964-35974 VBN denotes identified
T21704 35975-35977 IN denotes as
T21705 35978-35987 VBG denotes harboring
T21706 35988-35991 NN denotes QTL
T21707 35992-35993 -LRB- denotes [
T21708 35993-35994 CD denotes 1
T21709 35994-35995 -RRB- denotes ]
T21710 35995-35997 , denotes ,
T21711 35997-36002 WDT denotes which
T21713 36003-36007 VBD denotes were
T21714 36008-36012 RBR denotes more
T21715 36013-36020 RB denotes densely
T21712 36021-36029 VBN denotes screened
T21716 36029-36030 . denotes .
T21717 36030-36196 sentence denotes The "best" N2 agouti male with the lowest level of genome-wide unwanted heterozygosity while maintaining CAST alleles for all MMU2 markers was selected for breeding.
T21718 36031-36034 DT denotes The
T21720 36035-36036 `` denotes "
T21721 36036-36040 JJS denotes best
T21722 36040-36041 '' denotes "
T21723 36042-36044 NN denotes N2
T21724 36045-36051 NN denotes agouti
T21719 36052-36056 NN denotes male
T21726 36057-36061 IN denotes with
T21727 36062-36065 DT denotes the
T21729 36066-36072 JJS denotes lowest
T21728 36073-36078 NN denotes level
T21730 36079-36081 IN denotes of
T21731 36082-36088 NN denotes genome
T21733 36088-36089 HYPH denotes -
T21732 36089-36093 JJ denotes wide
T21735 36094-36102 JJ denotes unwanted
T21734 36103-36117 NN denotes heterozygosity
T21736 36118-36123 IN denotes while
T21737 36124-36135 VBG denotes maintaining
T21738 36136-36140 NN denotes CAST
T21739 36141-36148 NNS denotes alleles
T21740 36149-36152 IN denotes for
T21741 36153-36156 DT denotes all
T21743 36157-36161 NN denotes MMU2
T21742 36162-36169 NNS denotes markers
T21744 36170-36173 VBD denotes was
T21725 36174-36182 VBN denotes selected
T21745 36183-36186 IN denotes for
T21746 36187-36195 NN denotes breeding
T21747 36195-36196 . denotes .
T21748 36196-36330 sentence denotes This selection scheme was used at each generation until a N4 male was identified as homozygous HG for all markers typed outside MMU2.
T21749 36197-36201 DT denotes This
T21751 36202-36211 NN denotes selection
T21750 36212-36218 NN denotes scheme
T21753 36219-36222 VBD denotes was
T21752 36223-36227 VBN denotes used
T21754 36228-36230 IN denotes at
T21755 36231-36235 DT denotes each
T21756 36236-36246 NN denotes generation
T21757 36247-36252 IN denotes until
T21759 36253-36254 DT denotes a
T21761 36255-36257 NN denotes N4
T21760 36258-36262 NN denotes male
T21762 36263-36266 VBD denotes was
T21758 36267-36277 VBN denotes identified
T21763 36278-36280 IN denotes as
T21764 36281-36291 JJ denotes homozygous
T21765 36292-36294 NN denotes HG
T21766 36295-36298 IN denotes for
T21767 36299-36302 DT denotes all
T21768 36303-36310 NNS denotes markers
T21769 36311-36316 VBN denotes typed
T21770 36317-36324 IN denotes outside
T21771 36325-36329 NN denotes MMU2
T21772 36329-36330 . denotes .
T21773 36330-36474 sentence denotes After an additional backcross to HG females, recombinant males were identified providing the foundation for the four overlapping donor regions.
T21774 36331-36336 IN denotes After
T21776 36337-36339 DT denotes an
T21778 36340-36350 JJ denotes additional
T21777 36351-36360 NN denotes backcross
T21779 36361-36363 IN denotes to
T21780 36364-36366 NN denotes HG
T21781 36367-36374 NNS denotes females
T21782 36374-36376 , denotes ,
T21783 36376-36387 JJ denotes recombinant
T21784 36388-36393 NNS denotes males
T21785 36394-36398 VBD denotes were
T21775 36399-36409 VBN denotes identified
T21786 36410-36419 VBG denotes providing
T21787 36420-36423 DT denotes the
T21788 36424-36434 NN denotes foundation
T21789 36435-36438 IN denotes for
T21790 36439-36442 DT denotes the
T21792 36443-36447 CD denotes four
T21793 36448-36459 VBG denotes overlapping
T21794 36460-36465 NN denotes donor
T21791 36466-36473 NNS denotes regions
T21795 36473-36474 . denotes .
T21796 36474-36629 sentence denotes Selected recombinant males were then backcrossed to both B6 and HG females to create strains, which were B6 (+/+) or HG (hg/hg) and heterozygous congenic.
T21797 36475-36483 VBN denotes Selected
T21799 36484-36495 JJ denotes recombinant
T21798 36496-36501 NNS denotes males
T21801 36502-36506 VBD denotes were
T21802 36507-36511 RB denotes then
T21800 36512-36523 VBN denotes backcrossed
T21803 36524-36526 IN denotes to
T21804 36527-36531 CC denotes both
T21805 36532-36534 NN denotes B6
T21807 36535-36538 CC denotes and
T21808 36539-36541 NN denotes HG
T21806 36542-36549 NNS denotes females
T21809 36550-36552 TO denotes to
T21810 36553-36559 VB denotes create
T21811 36560-36567 NNS denotes strains
T21812 36567-36569 , denotes ,
T21813 36569-36574 WDT denotes which
T21814 36575-36579 VBD denotes were
T21815 36580-36582 NN denotes B6
T21817 36583-36584 -LRB- denotes (
T21819 36584-36585 SYM denotes +
T21820 36585-36586 HYPH denotes /
T21818 36586-36587 SYM denotes +
T21821 36587-36588 -RRB- denotes )
T21822 36589-36591 CC denotes or
T21823 36592-36594 NN denotes HG
T21824 36595-36596 -LRB- denotes (
T21826 36596-36598 NN denotes hg
T21827 36598-36599 HYPH denotes /
T21825 36599-36601 NN denotes hg
T21828 36601-36602 -RRB- denotes )
T21829 36603-36606 CC denotes and
T21830 36607-36619 JJ denotes heterozygous
T21816 36620-36628 JJ denotes congenic
T21831 36628-36629 . denotes .
T21832 36629-36704 sentence denotes These mice were intermated to produce homozygous founders for each strain.
T21833 36630-36635 DT denotes These
T21834 36636-36640 NNS denotes mice
T21836 36641-36645 VBD denotes were
T21835 36646-36656 VBN denotes intermated
T21837 36657-36659 TO denotes to
T21838 36660-36667 VB denotes produce
T21839 36668-36678 JJ denotes homozygous
T21840 36679-36687 NNS denotes founders
T21841 36688-36691 IN denotes for
T21842 36692-36696 DT denotes each
T21843 36697-36703 NN denotes strain
T21844 36703-36704 . denotes .
T21845 36704-36918 sentence denotes This novel breeding scheme created four identical founder congenics on two backgrounds B6 (+/+) and HG (hg/hg), which formed the basis for our examination of interactions caused by the presence of the hg deletion.
T21846 36705-36709 DT denotes This
T21848 36710-36715 JJ denotes novel
T21849 36716-36724 VBG denotes breeding
T21847 36725-36731 NN denotes scheme
T21850 36732-36739 VBD denotes created
T21851 36740-36744 CD denotes four
T21853 36745-36754 JJ denotes identical
T21854 36755-36762 NN denotes founder
T21852 36763-36772 NNS denotes congenics
T21855 36773-36775 IN denotes on
T21856 36776-36779 CD denotes two
T21857 36780-36791 NNS denotes backgrounds
T21858 36792-36794 NN denotes B6
T21859 36795-36796 -LRB- denotes (
T21861 36796-36797 SYM denotes +
T21862 36797-36798 HYPH denotes /
T21860 36798-36799 SYM denotes +
T21863 36799-36800 -RRB- denotes )
T21864 36801-36804 CC denotes and
T21865 36805-36807 NN denotes HG
T21866 36808-36809 -LRB- denotes (
T21868 36809-36811 NN denotes hg
T21869 36811-36812 HYPH denotes /
T21867 36812-36814 NN denotes hg
T21870 36814-36815 -RRB- denotes )
T21871 36815-36817 , denotes ,
T21872 36817-36822 WDT denotes which
T21873 36823-36829 VBD denotes formed
T21874 36830-36833 DT denotes the
T21875 36834-36839 NN denotes basis
T21876 36840-36843 IN denotes for
T21877 36844-36847 PRP$ denotes our
T21878 36848-36859 NN denotes examination
T21879 36860-36862 IN denotes of
T21880 36863-36875 NNS denotes interactions
T21881 36876-36882 VBN denotes caused
T21882 36883-36885 IN denotes by
T21883 36886-36889 DT denotes the
T21884 36890-36898 NN denotes presence
T21885 36899-36901 IN denotes of
T21886 36902-36905 DT denotes the
T21888 36906-36908 NN denotes hg
T21887 36909-36917 NN denotes deletion
T21889 36917-36918 . denotes .
T21890 36918-36993 sentence denotes MMU2 speed congenic strains were maintained through brother-sister mating.
T21891 36919-36923 NN denotes MMU2
T21893 36924-36929 NN denotes speed
T21894 36930-36938 JJ denotes congenic
T21892 36939-36946 NNS denotes strains
T21896 36947-36951 VBD denotes were
T21895 36952-36962 VBN denotes maintained
T21897 36963-36970 IN denotes through
T21898 36971-36978 NN denotes brother
T21900 36978-36979 HYPH denotes -
T21899 36979-36985 NN denotes sister
T21901 36986-36992 NN denotes mating
T21902 36992-36993 . denotes .
T21903 36993-37158 sentence denotes Once each congenic was stabilized, 20 additional microsatellite markers were used to refine the position of each congenic recombinant end point (Additional File 2).
T21904 36994-36998 RB denotes Once
T21906 36999-37003 DT denotes each
T21907 37004-37012 JJ denotes congenic
T21908 37013-37016 VBD denotes was
T21905 37017-37027 VBN denotes stabilized
T21910 37027-37029 , denotes ,
T21911 37029-37031 CD denotes 20
T21913 37032-37042 JJ denotes additional
T21914 37043-37057 NN denotes microsatellite
T21912 37058-37065 NNS denotes markers
T21915 37066-37070 VBD denotes were
T21909 37071-37075 VBN denotes used
T21916 37076-37078 TO denotes to
T21917 37079-37085 VB denotes refine
T21918 37086-37089 DT denotes the
T21919 37090-37098 NN denotes position
T21920 37099-37101 IN denotes of
T21921 37102-37106 DT denotes each
T21923 37107-37115 JJ denotes congenic
T21924 37116-37127 JJ denotes recombinant
T21925 37128-37131 NN denotes end
T21922 37132-37137 NN denotes point
T21926 37138-37139 -LRB- denotes (
T21928 37139-37149 JJ denotes Additional
T21927 37150-37154 NN denotes File
T21929 37155-37156 CD denotes 2
T21930 37156-37157 -RRB- denotes )
T21931 37157-37158 . denotes .
T22598 37160-37171 NN denotes Development
T22599 37172-37174 IN denotes of
T22600 37175-37182 NN denotes HG.CAST
T22602 37183-37188 NN denotes speed
T22603 37189-37197 JJ denotes congenic
T22601 37198-37205 NNS denotes strains
T22604 37206-37209 IN denotes for
T22605 37210-37213 NN denotes MMU
T22606 37213-37214 CD denotes 1
T22607 37214-37216 , denotes ,
T22608 37216-37217 CD denotes 5
T22609 37217-37219 , denotes ,
T22610 37219-37220 CD denotes 8
T22611 37220-37222 , denotes ,
T22612 37222-37223 CD denotes 9
T22613 37223-37225 , denotes ,
T22614 37225-37227 CD denotes 11
T22615 37228-37231 CC denotes and
T22616 37232-37234 CD denotes 17
T22617 37234-37537 sentence denotes All black N2 males from the first two crosses described above were genotyped for 12 markers (D1Mit432, -480, D5Mit353, -311, D9Mit60, -262, D11Mit5, -67, D8Mit234, -211 and D17Mit28 and -142), two spanning each of the six QTL harboring regions (MMU1, 5, 8, 9, 11 and 17; Table 1 and Additional File 1).
T22618 37235-37238 DT denotes All
T22620 37239-37244 JJ denotes black
T22621 37245-37247 NN denotes N2
T22619 37248-37253 NNS denotes males
T22623 37254-37258 IN denotes from
T22624 37259-37262 DT denotes the
T22626 37263-37268 JJ denotes first
T22627 37269-37272 CD denotes two
T22625 37273-37280 NNS denotes crosses
T22628 37281-37290 VBN denotes described
T22629 37291-37296 RB denotes above
T22630 37297-37301 VBD denotes were
T22622 37302-37311 VBN denotes genotyped
T22631 37312-37315 IN denotes for
T22632 37316-37318 CD denotes 12
T22633 37319-37326 NNS denotes markers
T22634 37327-37328 -LRB- denotes (
T22635 37328-37336 NN denotes D1Mit432
T22636 37336-37338 , denotes ,
T22637 37338-37339 SYM denotes -
T22638 37339-37342 CD denotes 480
T22639 37342-37344 , denotes ,
T22640 37344-37352 NN denotes D5Mit353
T22641 37352-37354 , denotes ,
T22642 37354-37355 SYM denotes -
T22643 37355-37358 CD denotes 311
T22644 37358-37360 , denotes ,
T22645 37360-37367 NN denotes D9Mit60
T22646 37367-37369 , denotes ,
T22647 37369-37370 SYM denotes -
T22648 37370-37373 CD denotes 262
T22649 37373-37375 , denotes ,
T22650 37375-37382 NN denotes D11Mit5
T22651 37382-37384 , denotes ,
T22652 37384-37385 SYM denotes -
T22653 37385-37387 CD denotes 67
T22654 37387-37389 , denotes ,
T22655 37389-37397 NN denotes D8Mit234
T22656 37397-37399 , denotes ,
T22657 37399-37400 SYM denotes -
T22658 37400-37403 CD denotes 211
T22659 37404-37407 CC denotes and
T22660 37408-37416 NN denotes D17Mit28
T22661 37417-37420 CC denotes and
T22662 37421-37422 SYM denotes -
T22663 37422-37425 CD denotes 142
T22664 37425-37426 -RRB- denotes )
T22665 37426-37428 , denotes ,
T22666 37428-37431 CD denotes two
T22667 37432-37440 VBG denotes spanning
T22668 37441-37445 DT denotes each
T22669 37446-37448 IN denotes of
T22670 37449-37452 DT denotes the
T22672 37453-37456 CD denotes six
T22673 37457-37460 NNS denotes QTL
T22674 37461-37470 VBG denotes harboring
T22671 37471-37478 NNS denotes regions
T22675 37479-37480 -LRB- denotes (
T22676 37480-37483 NN denotes MMU
T22677 37483-37484 CD denotes 1
T22678 37484-37486 , denotes ,
T22679 37486-37487 CD denotes 5
T22680 37487-37489 , denotes ,
T22681 37489-37490 CD denotes 8
T22682 37490-37492 , denotes ,
T22683 37492-37493 CD denotes 9
T22684 37493-37495 , denotes ,
T22685 37495-37497 CD denotes 11
T22686 37498-37501 CC denotes and
T22687 37502-37504 CD denotes 17
T22688 37504-37505 : denotes ;
T22689 37506-37511 NN denotes Table
T22690 37512-37513 CD denotes 1
T22691 37514-37517 CC denotes and
T22692 37518-37528 JJ denotes Additional
T22693 37529-37533 NN denotes File
T22694 37534-37535 CD denotes 1
T22695 37535-37536 -RRB- denotes )
T22696 37536-37537 . denotes .
T22697 37537-37613 sentence denotes Markers were selected to capture, at a minimum, the 2-LOD support interval.
T22698 37538-37545 NNS denotes Markers
T22700 37546-37550 VBD denotes were
T22699 37551-37559 VBN denotes selected
T22701 37560-37562 TO denotes to
T22702 37563-37570 VB denotes capture
T22703 37570-37572 , denotes ,
T22704 37572-37574 IN denotes at
T22705 37575-37576 DT denotes a
T22706 37577-37584 NN denotes minimum
T22707 37584-37586 , denotes ,
T22708 37586-37589 DT denotes the
T22710 37590-37591 CD denotes 2
T22712 37591-37592 HYPH denotes -
T22711 37592-37595 NN denotes LOD
T22713 37596-37603 NN denotes support
T22709 37604-37612 NN denotes interval
T22714 37612-37613 . denotes .
T22715 37613-37780 sentence denotes Two N2 males were selected to propagate the N3 generation; one heterozygous for QTL on MMU1 and 9 and the other heterozygous for QTL on MMU5, 8, 11 and 17 (Figure 1).
T22716 37614-37617 CD denotes Two
T22718 37618-37620 NN denotes N2
T22717 37621-37626 NNS denotes males
T22720 37627-37631 VBD denotes were
T22719 37632-37640 VBN denotes selected
T22721 37641-37643 TO denotes to
T22722 37644-37653 VB denotes propagate
T22723 37654-37657 DT denotes the
T22725 37658-37660 NN denotes N3
T22724 37661-37671 NN denotes generation
T22726 37671-37672 : denotes ;
T22727 37673-37676 CD denotes one
T22728 37677-37689 JJ denotes heterozygous
T22729 37690-37693 IN denotes for
T22730 37694-37697 NN denotes QTL
T22731 37698-37700 IN denotes on
T22732 37701-37704 NN denotes MMU
T22733 37704-37705 CD denotes 1
T22734 37706-37709 CC denotes and
T22735 37710-37711 CD denotes 9
T22736 37712-37715 CC denotes and
T22737 37716-37719 DT denotes the
T22738 37720-37725 JJ denotes other
T22739 37726-37738 NN denotes heterozygous
T22740 37739-37742 IN denotes for
T22741 37743-37746 NN denotes QTL
T22742 37747-37749 IN denotes on
T22743 37750-37753 NN denotes MMU
T22744 37753-37754 CD denotes 5
T22745 37754-37756 , denotes ,
T22746 37756-37757 CD denotes 8
T22747 37757-37759 , denotes ,
T22748 37759-37761 CD denotes 11
T22749 37762-37765 CC denotes and
T22750 37766-37768 CD denotes 17
T22751 37769-37770 -LRB- denotes (
T22752 37770-37776 NN denotes Figure
T22753 37777-37778 CD denotes 1
T22754 37778-37779 -RRB- denotes )
T22755 37779-37780 . denotes .
T22756 37780-37846 sentence denotes Both males were homozygous for HG alleles at all other known QTL.
T22757 37781-37785 DT denotes Both
T22758 37786-37791 NNS denotes males
T22759 37792-37796 VBD denotes were
T22760 37797-37807 JJ denotes homozygous
T22761 37808-37811 IN denotes for
T22762 37812-37814 NN denotes HG
T22763 37815-37822 NNS denotes alleles
T22764 37823-37825 IN denotes at
T22765 37826-37829 DT denotes all
T22767 37830-37835 JJ denotes other
T22768 37836-37841 VBN denotes known
T22766 37842-37845 NN denotes QTL
T22769 37845-37846 . denotes .
T22770 37846-37997 sentence denotes These males were backcrossed to HG females and two of the resulting N3 males inheriting the same sets of QTL as their sire were selected for breeding.
T22771 37847-37852 DT denotes These
T22772 37853-37858 NNS denotes males
T22774 37859-37863 VBD denotes were
T22773 37864-37875 VBN denotes backcrossed
T22775 37876-37878 IN denotes to
T22776 37879-37881 NN denotes HG
T22777 37882-37889 NNS denotes females
T22778 37890-37893 CC denotes and
T22779 37894-37897 CD denotes two
T22781 37898-37900 IN denotes of
T22782 37901-37904 DT denotes the
T22784 37905-37914 VBG denotes resulting
T22785 37915-37917 NN denotes N3
T22783 37918-37923 NNS denotes males
T22786 37924-37934 VBG denotes inheriting
T22787 37935-37938 DT denotes the
T22789 37939-37943 JJ denotes same
T22788 37944-37948 NNS denotes sets
T22790 37949-37951 IN denotes of
T22791 37952-37955 NN denotes QTL
T22792 37956-37958 IN denotes as
T22793 37959-37964 PRP$ denotes their
T22794 37965-37969 NN denotes sire
T22795 37970-37974 VBD denotes were
T22780 37975-37983 VBN denotes selected
T22796 37984-37987 IN denotes for
T22797 37988-37996 NN denotes breeding
T22798 37996-37997 . denotes .
T22799 37997-38190 sentence denotes These males were subsequently backcrossed to HG females and three N4 males were identified heterozygous for the following regions: 1) MMU1 and 9; 2) MMU5 and 11; 3) MMU8, 11 and 17 (Figure 1).
T22800 37998-38003 DT denotes These
T22801 38004-38009 NNS denotes males
T22803 38010-38014 VBD denotes were
T22804 38015-38027 RB denotes subsequently
T22802 38028-38039 VBN denotes backcrossed
T22805 38040-38042 IN denotes to
T22806 38043-38045 NN denotes HG
T22807 38046-38053 NNS denotes females
T22808 38054-38057 CC denotes and
T22809 38058-38063 CD denotes three
T22811 38064-38066 NN denotes N4
T22810 38067-38072 NNS denotes males
T22813 38073-38077 VBD denotes were
T22812 38078-38088 VBN denotes identified
T22814 38089-38101 JJ denotes heterozygous
T22815 38102-38105 IN denotes for
T22816 38106-38109 DT denotes the
T22818 38110-38119 VBG denotes following
T22817 38120-38127 NNS denotes regions
T22819 38127-38129 : denotes :
T22820 38129-38130 LS denotes 1
T22822 38130-38131 -RRB- denotes )
T22823 38132-38135 NN denotes MMU
T22821 38135-38136 CD denotes 1
T22824 38137-38140 CC denotes and
T22825 38141-38142 CD denotes 9
T22826 38142-38143 : denotes ;
T22827 38144-38145 LS denotes 2
T22829 38145-38146 -RRB- denotes )
T22830 38147-38150 NN denotes MMU
T22828 38150-38151 CD denotes 5
T22831 38152-38155 CC denotes and
T22832 38156-38158 CD denotes 11
T22833 38158-38159 : denotes ;
T22834 38160-38161 LS denotes 3
T22836 38161-38162 -RRB- denotes )
T22837 38163-38166 NN denotes MMU
T22835 38166-38167 CD denotes 8
T22838 38167-38169 , denotes ,
T22839 38169-38171 CD denotes 11
T22840 38172-38175 CC denotes and
T22841 38176-38178 CD denotes 17
T22842 38179-38180 -LRB- denotes (
T22843 38180-38186 NN denotes Figure
T22844 38187-38188 CD denotes 1
T22845 38188-38189 -RRB- denotes )
T22846 38189-38190 . denotes .
T22847 38190-38497 sentence denotes Starting at N4 and continuing through N6, the "best" male with the lowest percent of unwanted donor alleles was selected after performing a genome scan using the remaining 67 genome-wide markers (79 total markers minus the 12 markers genotyped in the first two backcrosses spanning the know QTL intervals).
T22848 38191-38199 VBG denotes Starting
T22850 38200-38202 IN denotes at
T22851 38203-38205 NN denotes N4
T22852 38206-38209 CC denotes and
T22853 38210-38220 VBG denotes continuing
T22854 38221-38228 IN denotes through
T22855 38229-38231 NN denotes N6
T22856 38231-38233 , denotes ,
T22857 38233-38236 DT denotes the
T22859 38237-38238 `` denotes "
T22860 38238-38242 JJS denotes best
T22861 38242-38243 '' denotes "
T22858 38244-38248 JJ denotes male
T22862 38249-38253 IN denotes with
T22863 38254-38257 DT denotes the
T22865 38258-38264 JJS denotes lowest
T22864 38265-38272 NN denotes percent
T22866 38273-38275 IN denotes of
T22867 38276-38284 JJ denotes unwanted
T22869 38285-38290 NN denotes donor
T22868 38291-38298 NNS denotes alleles
T22870 38299-38302 VBD denotes was
T22849 38303-38311 VBN denotes selected
T22871 38312-38317 IN denotes after
T22872 38318-38328 VBG denotes performing
T22873 38329-38330 DT denotes a
T22875 38331-38337 NN denotes genome
T22874 38338-38342 NN denotes scan
T22876 38343-38348 VBG denotes using
T22877 38349-38352 DT denotes the
T22879 38353-38362 VBG denotes remaining
T22880 38363-38365 CD denotes 67
T22881 38366-38372 NN denotes genome
T22883 38372-38373 HYPH denotes -
T22882 38373-38377 JJ denotes wide
T22878 38378-38385 NNS denotes markers
T22884 38386-38387 -LRB- denotes (
T22886 38387-38389 CD denotes 79
T22887 38390-38395 JJ denotes total
T22885 38396-38403 NNS denotes markers
T22888 38404-38409 CC denotes minus
T22889 38410-38413 DT denotes the
T22891 38414-38416 CD denotes 12
T22890 38417-38424 NNS denotes markers
T22892 38425-38434 VBN denotes genotyped
T22893 38435-38437 IN denotes in
T22894 38438-38441 DT denotes the
T22896 38442-38447 JJ denotes first
T22897 38448-38451 CD denotes two
T22895 38452-38463 NNS denotes backcrosses
T22898 38464-38472 VBG denotes spanning
T22899 38473-38476 DT denotes the
T22901 38477-38481 JJ denotes know
T22902 38482-38485 NN denotes QTL
T22900 38486-38495 NNS denotes intervals
T22903 38495-38496 -RRB- denotes )
T22904 38496-38497 . denotes .
T22905 38497-38628 sentence denotes At N5 a distinct strain was created for each of the six individual donor regions and heterozygous mice were intermated (Figure 1).
T22906 38498-38500 IN denotes At
T22908 38501-38503 NN denotes N5
T22909 38504-38505 DT denotes a
T22911 38506-38514 JJ denotes distinct
T22910 38515-38521 NN denotes strain
T22912 38522-38525 VBD denotes was
T22907 38526-38533 VBN denotes created
T22913 38534-38537 IN denotes for
T22914 38538-38542 DT denotes each
T22915 38543-38545 IN denotes of
T22916 38546-38549 DT denotes the
T22918 38550-38553 CD denotes six
T22919 38554-38564 JJ denotes individual
T22920 38565-38570 NN denotes donor
T22917 38571-38578 NNS denotes regions
T22921 38579-38582 CC denotes and
T22922 38583-38595 JJ denotes heterozygous
T22923 38596-38600 NNS denotes mice
T22925 38601-38605 VBD denotes were
T22924 38606-38616 VBN denotes intermated
T22926 38617-38618 -LRB- denotes (
T22927 38618-38624 NN denotes Figure
T22928 38625-38626 CD denotes 1
T22929 38626-38627 -RRB- denotes )
T22930 38627-38628 . denotes .
T22931 38628-38717 sentence denotes Homozygous HG.CAST speed congenic strains were maintained through brother-sister mating.
T22932 38629-38639 JJ denotes Homozygous
T22934 38640-38647 NN denotes HG.CAST
T22935 38648-38653 NN denotes speed
T22936 38654-38662 JJ denotes congenic
T22933 38663-38670 NNS denotes strains
T22938 38671-38675 VBD denotes were
T22937 38676-38686 VBN denotes maintained
T22939 38687-38694 IN denotes through
T22940 38695-38702 NN denotes brother
T22942 38702-38703 HYPH denotes -
T22941 38703-38709 NN denotes sister
T22943 38710-38716 NN denotes mating
T22944 38716-38717 . denotes .
T22945 38717-38882 sentence denotes Once each congenic was stabilized, 19 additional microsatellite markers were used to refine the position of each congenic recombinant end point (Additional File 2).
T22946 38718-38722 IN denotes Once
T22948 38723-38727 DT denotes each
T22949 38728-38736 JJ denotes congenic
T22950 38737-38740 VBD denotes was
T22947 38741-38751 VBN denotes stabilized
T22952 38751-38753 , denotes ,
T22953 38753-38755 CD denotes 19
T22955 38756-38766 JJ denotes additional
T22956 38767-38781 NN denotes microsatellite
T22954 38782-38789 NNS denotes markers
T22957 38790-38794 VBD denotes were
T22951 38795-38799 VBN denotes used
T22958 38800-38802 TO denotes to
T22959 38803-38809 VB denotes refine
T22960 38810-38813 DT denotes the
T22961 38814-38822 NN denotes position
T22962 38823-38825 IN denotes of
T22963 38826-38830 DT denotes each
T22965 38831-38839 JJ denotes congenic
T22966 38840-38851 JJ denotes recombinant
T22967 38852-38855 NN denotes end
T22964 38856-38861 NN denotes point
T22968 38862-38863 -LRB- denotes (
T22970 38863-38873 JJ denotes Additional
T22969 38874-38878 NN denotes File
T22971 38879-38880 CD denotes 2
T22972 38880-38881 -RRB- denotes )
T22973 38881-38882 . denotes .
T23420 38884-38895 NN denotes Development
T23421 38896-38898 IN denotes of
T23422 38899-38907 NN denotes B6.CASTC
T23424 38908-38911 CC denotes and
T23425 38912-38920 NN denotes HG.CASTC
T23426 38921-38928 NN denotes control
T23423 38929-38936 NNS denotes strains
T23427 38936-39259 sentence denotes HG is a strain in which the hg deletion has been introgressed onto a B6 background, therefore the only genetic differences between the strains would be the hg locus, tightly linked alleles from the outbred strain on which hg arose and contaminating alleles remaining after the nine backcrosses and fixed during inbreeding.
T23428 38937-38939 NN denotes HG
T23429 38940-38942 VBZ denotes is
T23431 38943-38944 DT denotes a
T23432 38945-38951 NN denotes strain
T23433 38952-38954 IN denotes in
T23435 38955-38960 WDT denotes which
T23436 38961-38964 DT denotes the
T23438 38965-38967 NN denotes hg
T23437 38968-38976 NN denotes deletion
T23439 38977-38980 VBZ denotes has
T23440 38981-38985 VBN denotes been
T23434 38986-38998 VBN denotes introgressed
T23441 38999-39003 IN denotes onto
T23442 39004-39005 DT denotes a
T23444 39006-39008 NN denotes B6
T23443 39009-39019 NN denotes background
T23445 39019-39021 , denotes ,
T23446 39021-39030 RB denotes therefore
T23447 39031-39034 DT denotes the
T23449 39035-39039 JJ denotes only
T23450 39040-39047 JJ denotes genetic
T23448 39048-39059 NNS denotes differences
T23451 39060-39067 IN denotes between
T23452 39068-39071 DT denotes the
T23453 39072-39079 NNS denotes strains
T23454 39080-39085 MD denotes would
T23430 39086-39088 VB denotes be
T23455 39089-39092 DT denotes the
T23457 39093-39095 NN denotes hg
T23456 39096-39101 NN denotes locus
T23458 39101-39103 , denotes ,
T23459 39103-39110 RB denotes tightly
T23460 39111-39117 VBN denotes linked
T23461 39118-39125 NNS denotes alleles
T23462 39126-39130 IN denotes from
T23463 39131-39134 DT denotes the
T23465 39135-39142 VBN denotes outbred
T23464 39143-39149 NN denotes strain
T23466 39150-39152 IN denotes on
T23468 39153-39158 WDT denotes which
T23469 39159-39161 NN denotes hg
T23467 39162-39167 VBD denotes arose
T23470 39168-39171 CC denotes and
T23471 39172-39185 VBG denotes contaminating
T23472 39186-39193 NNS denotes alleles
T23473 39194-39203 VBG denotes remaining
T23474 39204-39209 IN denotes after
T23475 39210-39213 DT denotes the
T23477 39214-39218 CD denotes nine
T23476 39219-39230 NNS denotes backcrosses
T23478 39231-39234 CC denotes and
T23479 39235-39240 VBN denotes fixed
T23480 39241-39247 IN denotes during
T23481 39248-39258 NN denotes inbreeding
T23482 39258-39259 . denotes .
T23483 39259-39473 sentence denotes Instead of using parental B6 and HG strains as controls for phenotypic comparisons with each speed congenic, we choose to develop independent control strains originating from the same cross as the congenic panels.
T23484 39260-39267 RB denotes Instead
T23485 39268-39270 IN denotes of
T23487 39271-39276 VBG denotes using
T23488 39277-39285 JJ denotes parental
T23490 39286-39288 NN denotes B6
T23491 39289-39292 CC denotes and
T23492 39293-39295 NN denotes HG
T23489 39296-39303 NNS denotes strains
T23493 39304-39306 IN denotes as
T23494 39307-39315 NNS denotes controls
T23495 39316-39319 IN denotes for
T23496 39320-39330 JJ denotes phenotypic
T23497 39331-39342 NNS denotes comparisons
T23498 39343-39347 IN denotes with
T23499 39348-39352 DT denotes each
T23500 39353-39358 NN denotes speed
T23501 39359-39367 JJ denotes congenic
T23502 39367-39369 , denotes ,
T23503 39369-39371 PRP denotes we
T23486 39372-39378 VBP denotes choose
T23504 39379-39381 TO denotes to
T23505 39382-39389 VB denotes develop
T23506 39390-39401 JJ denotes independent
T23508 39402-39409 NN denotes control
T23507 39410-39417 NNS denotes strains
T23509 39418-39429 VBG denotes originating
T23510 39430-39434 IN denotes from
T23511 39435-39438 DT denotes the
T23513 39439-39443 JJ denotes same
T23512 39444-39449 NN denotes cross
T23514 39450-39452 IN denotes as
T23515 39453-39456 DT denotes the
T23517 39457-39465 JJ denotes congenic
T23516 39466-39472 NNS denotes panels
T23518 39472-39473 . denotes .
T23519 39473-39590 sentence denotes Separate B6.CAST control (B6C) and HG.CAST control (HGC) strains were developed using mice from the MMU2 experiment.
T23520 39474-39482 JJ denotes Separate
T23522 39483-39490 NN denotes B6.CAST
T23523 39491-39498 NN denotes control
T23524 39499-39500 -LRB- denotes (
T23525 39500-39503 NN denotes B6C
T23526 39503-39504 -RRB- denotes )
T23527 39505-39508 CC denotes and
T23528 39509-39516 NN denotes HG.CAST
T23529 39517-39524 NN denotes control
T23530 39525-39526 -LRB- denotes (
T23531 39526-39529 NN denotes HGC
T23532 39529-39530 -RRB- denotes )
T23521 39531-39538 NNS denotes strains
T23534 39539-39543 VBD denotes were
T23533 39544-39553 VBN denotes developed
T23535 39554-39559 VBG denotes using
T23536 39560-39564 NNS denotes mice
T23537 39565-39569 IN denotes from
T23538 39570-39573 DT denotes the
T23540 39574-39578 NN denotes MMU2
T23539 39579-39589 NN denotes experiment
T23541 39589-39590 . denotes .
T23542 39590-39738 sentence denotes Mice from the last backcross inheriting only B6 or HG MMU2 alleles at markers spanning MMU2 were intermated to serve as the basis for each control.
T23543 39591-39595 NNS denotes Mice
T23545 39596-39600 IN denotes from
T23546 39601-39604 DT denotes the
T23548 39605-39609 JJ denotes last
T23547 39610-39619 NN denotes backcross
T23549 39620-39630 VBG denotes inheriting
T23550 39631-39635 RB denotes only
T23552 39636-39638 NN denotes B6
T23553 39639-39641 CC denotes or
T23554 39642-39644 NN denotes HG
T23555 39645-39649 NN denotes MMU2
T23551 39650-39657 NNS denotes alleles
T23556 39658-39660 IN denotes at
T23557 39661-39668 NNS denotes markers
T23558 39669-39677 VBG denotes spanning
T23559 39678-39682 NN denotes MMU2
T23560 39683-39687 VBD denotes were
T23544 39688-39698 VBN denotes intermated
T23561 39699-39701 TO denotes to
T23562 39702-39707 VB denotes serve
T23563 39708-39710 IN denotes as
T23564 39711-39714 DT denotes the
T23565 39715-39720 NN denotes basis
T23566 39721-39724 IN denotes for
T23567 39725-39729 DT denotes each
T23568 39730-39737 NN denotes control
T23569 39737-39738 . denotes .
T23570 39738-39819 sentence denotes Both control strains were subsequently maintained through brother-sister mating.
T23571 39739-39743 DT denotes Both
T23573 39744-39751 NN denotes control
T23572 39752-39759 NNS denotes strains
T23575 39760-39764 VBD denotes were
T23576 39765-39777 RB denotes subsequently
T23574 39778-39788 VBN denotes maintained
T23577 39789-39796 IN denotes through
T23578 39797-39804 NN denotes brother
T23580 39804-39805 HYPH denotes -
T23579 39805-39811 NN denotes sister
T23581 39812-39818 NN denotes mating
T23582 39818-39819 . denotes .
T23583 39819-40043 sentence denotes The control strains were coisogenic with the parental B6 or HG strain with the exception of mutations that arose during congenic construction and a small percentage of contaminating donor alleles missed after 6 backcrosses.
T23584 39820-39823 DT denotes The
T23586 39824-39831 NN denotes control
T23585 39832-39839 NNS denotes strains
T23587 39840-39844 VBD denotes were
T23588 39845-39855 JJ denotes coisogenic
T23589 39856-39860 IN denotes with
T23590 39861-39864 DT denotes the
T23592 39865-39873 JJ denotes parental
T23593 39874-39876 NN denotes B6
T23594 39877-39879 CC denotes or
T23595 39880-39882 NN denotes HG
T23591 39883-39889 NN denotes strain
T23596 39890-39894 IN denotes with
T23597 39895-39898 DT denotes the
T23598 39899-39908 NN denotes exception
T23599 39909-39911 IN denotes of
T23600 39912-39921 NNS denotes mutations
T23601 39922-39926 WDT denotes that
T23602 39927-39932 VBD denotes arose
T23603 39933-39939 IN denotes during
T23604 39940-39948 JJ denotes congenic
T23605 39949-39961 NN denotes construction
T23606 39962-39965 CC denotes and
T23607 39966-39967 DT denotes a
T23609 39968-39973 JJ denotes small
T23608 39974-39984 NN denotes percentage
T23610 39985-39987 IN denotes of
T23611 39988-40001 VBG denotes contaminating
T23613 40002-40007 NN denotes donor
T23612 40008-40015 NNS denotes alleles
T23614 40016-40022 VBN denotes missed
T23615 40023-40028 IN denotes after
T23616 40029-40030 CD denotes 6
T23617 40031-40042 NNS denotes backcrosses
T23618 40042-40043 . denotes .
T23619 40043-40262 sentence denotes Therefore, since the congenics and controls were developed through the same selection scheme and possibly share common contaminating regions, the B6C and HGC strains are the most ideal control to compare each congenic.
T23620 40044-40053 RB denotes Therefore
T23622 40053-40055 , denotes ,
T23623 40055-40060 IN denotes since
T23625 40061-40064 DT denotes the
T23626 40065-40074 NNS denotes congenics
T23627 40075-40078 CC denotes and
T23628 40079-40087 NNS denotes controls
T23629 40088-40092 VBD denotes were
T23624 40093-40102 VBN denotes developed
T23630 40103-40110 IN denotes through
T23631 40111-40114 DT denotes the
T23633 40115-40119 JJ denotes same
T23634 40120-40129 NN denotes selection
T23632 40130-40136 NN denotes scheme
T23635 40137-40140 CC denotes and
T23636 40141-40149 RB denotes possibly
T23637 40150-40155 VBP denotes share
T23638 40156-40162 JJ denotes common
T23640 40163-40176 VBG denotes contaminating
T23639 40177-40184 NNS denotes regions
T23641 40184-40186 , denotes ,
T23642 40186-40189 DT denotes the
T23644 40190-40193 NN denotes B6C
T23645 40194-40197 CC denotes and
T23646 40198-40201 NN denotes HGC
T23643 40202-40209 NNS denotes strains
T23621 40210-40213 VBP denotes are
T23647 40214-40217 DT denotes the
T23649 40218-40222 RBS denotes most
T23650 40223-40228 JJ denotes ideal
T23648 40229-40236 NN denotes control
T23651 40237-40239 TO denotes to
T23652 40240-40247 VB denotes compare
T23653 40248-40252 DT denotes each
T23654 40253-40261 NN denotes congenic
T23655 40261-40262 . denotes .
T24427 40264-40274 JJ denotes Phenotypic
T24428 40275-40291 NN denotes characterization
T24429 40291-40398 sentence denotes Trait data were collected on approximately 40 mice (20 of each sex) from each congenic and control strain.
T24430 40292-40297 NN denotes Trait
T24431 40298-40302 NNS denotes data
T24433 40303-40307 VBD denotes were
T24432 40308-40317 VBN denotes collected
T24434 40318-40320 IN denotes on
T24435 40321-40334 RB denotes approximately
T24436 40335-40337 CD denotes 40
T24437 40338-40342 NNS denotes mice
T24438 40343-40344 -LRB- denotes (
T24439 40344-40346 CD denotes 20
T24440 40347-40349 IN denotes of
T24441 40350-40354 DT denotes each
T24442 40355-40358 NN denotes sex
T24443 40358-40359 -RRB- denotes )
T24444 40360-40364 IN denotes from
T24445 40365-40369 DT denotes each
T24447 40370-40378 JJ denotes congenic
T24448 40379-40382 CC denotes and
T24449 40383-40390 NN denotes control
T24446 40391-40397 NN denotes strain
T24450 40397-40398 . denotes .
T24451 40398-40555 sentence denotes To eliminate parity and reduce litter size effects only progeny from uniparous dams were characterized and all litters were standardized to 5–7 pups/litter.
T24452 40399-40401 TO denotes To
T24453 40402-40411 VB denotes eliminate
T24455 40412-40418 NN denotes parity
T24456 40419-40422 CC denotes and
T24457 40423-40429 VB denotes reduce
T24458 40430-40436 NN denotes litter
T24459 40437-40441 NN denotes size
T24460 40442-40449 NNS denotes effects
T24461 40450-40454 RB denotes only
T24462 40455-40462 NN denotes progeny
T24463 40463-40467 IN denotes from
T24464 40468-40477 JJ denotes uniparous
T24465 40478-40482 NNS denotes dams
T24466 40483-40487 VBD denotes were
T24454 40488-40501 VBN denotes characterized
T24467 40502-40505 CC denotes and
T24468 40506-40509 DT denotes all
T24469 40510-40517 NNS denotes litters
T24471 40518-40522 VBD denotes were
T24470 40523-40535 VBN denotes standardized
T24472 40536-40538 IN denotes to
T24473 40539-40540 CD denotes 5
T24475 40540-40541 SYM denotes –
T24474 40541-40542 CD denotes 7
T24476 40543-40547 NNS denotes pups
T24477 40547-40548 SYM denotes /
T24478 40548-40554 NN denotes litter
T24479 40554-40555 . denotes .
T24480 40555-40591 sentence denotes Mice were weaned at 3 weeks of age.
T24481 40556-40560 NNS denotes Mice
T24483 40561-40565 VBD denotes were
T24482 40566-40572 VBN denotes weaned
T24484 40573-40575 IN denotes at
T24485 40576-40577 CD denotes 3
T24486 40578-40583 NNS denotes weeks
T24487 40584-40586 IN denotes of
T24488 40587-40590 NN denotes age
T24489 40590-40591 . denotes .
T24490 40591-40682 sentence denotes Feed (Purina 5008; 23.5% protein, 6.5% fat, 3.3 Kcal/g) and water were offered ad libitum.
T24491 40592-40596 NN denotes Feed
T24493 40597-40598 -LRB- denotes (
T24495 40598-40604 NNP denotes Purina
T24496 40605-40609 CD denotes 5008
T24497 40609-40610 : denotes ;
T24498 40611-40615 CD denotes 23.5
T24499 40615-40616 NN denotes %
T24494 40617-40624 NN denotes protein
T24500 40624-40626 , denotes ,
T24501 40626-40629 CD denotes 6.5
T24502 40629-40630 NN denotes %
T24503 40631-40634 NN denotes fat
T24504 40634-40636 , denotes ,
T24505 40636-40639 CD denotes 3.3
T24506 40640-40644 NN denotes Kcal
T24507 40644-40645 SYM denotes /
T24508 40645-40646 NN denotes g
T24509 40646-40647 -RRB- denotes )
T24510 40648-40651 CC denotes and
T24511 40652-40657 NN denotes water
T24512 40658-40662 VBD denotes were
T24492 40663-40670 VBN denotes offered
T24513 40671-40673 FW denotes ad
T24514 40674-40681 FW denotes libitum
T24515 40681-40682 . denotes .
T24516 40682-40755 sentence denotes Mice were weighed to the nearest 0.1 g at 2WK, 3WK, 6WK, and 9WK of age.
T24517 40683-40687 NNS denotes Mice
T24519 40688-40692 VBD denotes were
T24518 40693-40700 VBN denotes weighed
T24520 40701-40703 IN denotes to
T24521 40704-40707 DT denotes the
T24523 40708-40715 JJS denotes nearest
T24524 40716-40719 CD denotes 0.1
T24522 40720-40721 NN denotes g
T24525 40722-40724 IN denotes at
T24526 40725-40728 NN denotes 2WK
T24527 40728-40730 , denotes ,
T24528 40730-40733 NN denotes 3WK
T24529 40733-40735 , denotes ,
T24530 40735-40738 NN denotes 6WK
T24531 40738-40740 , denotes ,
T24532 40740-40743 CC denotes and
T24533 40744-40747 NN denotes 9WK
T24534 40748-40750 IN denotes of
T24535 40751-40754 NN denotes age
T24536 40754-40755 . denotes .
T24537 40755-40894 sentence denotes At 9WK ( ± 5 days) mice were anesthetized under isoflurane and nasal-anal length (NA) and nasal-tail (NT) were measured to the nearest mm.
T24538 40756-40758 IN denotes At
T24540 40759-40762 NN denotes 9WK
T24541 40763-40764 -LRB- denotes (
T24542 40765-40766 SYM denotes ±
T24543 40767-40768 CD denotes 5
T24544 40769-40773 NNS denotes days
T24545 40773-40774 -RRB- denotes )
T24546 40775-40779 NNS denotes mice
T24547 40780-40784 VBD denotes were
T24539 40785-40797 VBN denotes anesthetized
T24548 40798-40803 IN denotes under
T24549 40804-40814 NN denotes isoflurane
T24550 40815-40818 CC denotes and
T24551 40819-40824 JJ denotes nasal
T24553 40824-40825 HYPH denotes -
T24552 40825-40829 JJ denotes anal
T24554 40830-40836 NN denotes length
T24556 40837-40838 -LRB- denotes (
T24557 40838-40840 NN denotes NA
T24558 40840-40841 -RRB- denotes )
T24559 40842-40845 CC denotes and
T24560 40846-40851 JJ denotes nasal
T24562 40851-40852 HYPH denotes -
T24561 40852-40856 NN denotes tail
T24563 40857-40858 -LRB- denotes (
T24564 40858-40860 NN denotes NT
T24565 40860-40861 -RRB- denotes )
T24566 40862-40866 VBD denotes were
T24555 40867-40875 VBN denotes measured
T24567 40876-40878 IN denotes to
T24568 40879-40882 DT denotes the
T24570 40883-40890 JJS denotes nearest
T24569 40891-40893 NN denotes mm
T24571 40893-40894 . denotes .
T24572 40894-40937 sentence denotes Tail length was calculated as NA minus NT.
T24573 40895-40899 NN denotes Tail
T24574 40900-40906 NN denotes length
T24576 40907-40910 VBD denotes was
T24575 40911-40921 VBN denotes calculated
T24577 40922-40924 IN denotes as
T24578 40925-40927 NN denotes NA
T24579 40928-40933 CC denotes minus
T24580 40934-40936 NN denotes NT
T24581 40936-40937 . denotes .
T24582 40937-41011 sentence denotes Anesthetized mice were then sacrificed by decapitation and exsanguinated.
T24583 40938-40950 VBN denotes Anesthetized
T24584 40951-40955 NNS denotes mice
T24586 40956-40960 VBD denotes were
T24587 40961-40965 RB denotes then
T24585 40966-40976 VBN denotes sacrificed
T24588 40977-40979 IN denotes by
T24589 40980-40992 NN denotes decapitation
T24590 40993-40996 CC denotes and
T24591 40997-41010 VBN denotes exsanguinated
T24592 41010-41011 . denotes .
T24593 41011-41160 sentence denotes Femoral fat pad (FFP), gonadal fat pad (GFP), mesenteric fat pad (MFP) and retroperitoneal fat pad (RFP) were removed and weighed to the nearest mg.
T24594 41012-41019 JJ denotes Femoral
T24596 41020-41023 NN denotes fat
T24595 41024-41027 NN denotes pad
T24598 41028-41029 -LRB- denotes (
T24599 41029-41032 NN denotes FFP
T24600 41032-41033 -RRB- denotes )
T24601 41033-41035 , denotes ,
T24602 41035-41042 JJ denotes gonadal
T24604 41043-41046 NN denotes fat
T24603 41047-41050 NN denotes pad
T24605 41051-41052 -LRB- denotes (
T24606 41052-41055 NN denotes GFP
T24607 41055-41056 -RRB- denotes )
T24608 41056-41058 , denotes ,
T24609 41058-41068 JJ denotes mesenteric
T24611 41069-41072 NN denotes fat
T24610 41073-41076 NN denotes pad
T24612 41077-41078 -LRB- denotes (
T24613 41078-41081 NN denotes MFP
T24614 41081-41082 -RRB- denotes )
T24615 41083-41086 CC denotes and
T24616 41087-41102 JJ denotes retroperitoneal
T24618 41103-41106 NN denotes fat
T24617 41107-41110 NN denotes pad
T24619 41111-41112 -LRB- denotes (
T24620 41112-41115 NN denotes RFP
T24621 41115-41116 -RRB- denotes )
T24622 41117-41121 VBD denotes were
T24597 41122-41129 VBN denotes removed
T24623 41130-41133 CC denotes and
T24624 41134-41141 VBN denotes weighed
T24625 41142-41144 IN denotes to
T24626 41145-41148 DT denotes the
T24628 41149-41156 JJS denotes nearest
T24627 41157-41159 NN denotes mg
T24629 41159-41160 . denotes .
T24630 41160-41295 sentence denotes Chemical compositional analysis was performed for HGC, HG11 and HG17 carcasses as previously described with slight modifications [24].
T24631 41161-41169 JJ denotes Chemical
T24633 41170-41183 JJ denotes compositional
T24632 41184-41192 NN denotes analysis
T24635 41193-41196 VBD denotes was
T24634 41197-41206 VBN denotes performed
T24636 41207-41210 IN denotes for
T24637 41211-41214 NN denotes HGC
T24639 41214-41216 , denotes ,
T24640 41216-41220 NN denotes HG11
T24641 41221-41224 CC denotes and
T24642 41225-41229 NN denotes HG17
T24638 41230-41239 NNS denotes carcasses
T24643 41240-41242 IN denotes as
T24645 41243-41253 RB denotes previously
T24644 41254-41263 VBN denotes described
T24646 41264-41268 IN denotes with
T24647 41269-41275 JJ denotes slight
T24648 41276-41289 NNS denotes modifications
T24649 41290-41291 -LRB- denotes [
T24650 41291-41293 CD denotes 24
T24651 41293-41294 -RRB- denotes ]
T24652 41294-41295 . denotes .
T24653 41295-41361 sentence denotes Briefly, after weighing each fat pad was returned to the carcass.
T24654 41296-41303 RB denotes Briefly
T24656 41303-41305 , denotes ,
T24657 41305-41310 IN denotes after
T24658 41311-41319 VBG denotes weighing
T24659 41320-41324 DT denotes each
T24661 41325-41328 NN denotes fat
T24660 41329-41332 NN denotes pad
T24662 41333-41336 VBD denotes was
T24655 41337-41345 VBN denotes returned
T24663 41346-41348 IN denotes to
T24664 41349-41352 DT denotes the
T24665 41353-41360 NN denotes carcass
T24666 41360-41361 . denotes .
T24667 41361-41459 sentence denotes The entire gastrointestinal (GI) tract was subsequently removed and carcasses were again weighed.
T24668 41362-41365 DT denotes The
T24670 41366-41372 JJ denotes entire
T24671 41373-41389 JJ denotes gastrointestinal
T24672 41390-41391 -LRB- denotes (
T24673 41391-41393 NN denotes GI
T24674 41393-41394 -RRB- denotes )
T24669 41395-41400 NN denotes tract
T24676 41401-41404 VBD denotes was
T24677 41405-41417 RB denotes subsequently
T24675 41418-41425 VBN denotes removed
T24678 41426-41429 CC denotes and
T24679 41430-41439 NNS denotes carcasses
T24681 41440-41444 VBD denotes were
T24682 41445-41450 RB denotes again
T24680 41451-41458 VBN denotes weighed
T24683 41458-41459 . denotes .
T24684 41459-41508 sentence denotes This represented the empty carcass weight (ECW).
T24685 41460-41464 DT denotes This
T24686 41465-41476 VBD denotes represented
T24687 41477-41480 DT denotes the
T24689 41481-41486 JJ denotes empty
T24690 41487-41494 NN denotes carcass
T24688 41495-41501 NN denotes weight
T24691 41502-41503 -LRB- denotes (
T24692 41503-41506 NN denotes ECW
T24693 41506-41507 -RRB- denotes )
T24694 41507-41508 . denotes .
T24695 41508-41617 sentence denotes Carcasses were labeled and secured in two layers of cheesecloth (Fisher) and frozen at -20°C until analysis.
T24696 41509-41518 NNS denotes Carcasses
T24698 41519-41523 VBD denotes were
T24697 41524-41531 VBN denotes labeled
T24699 41532-41535 CC denotes and
T24700 41536-41543 VBN denotes secured
T24701 41544-41546 IN denotes in
T24702 41547-41550 CD denotes two
T24703 41551-41557 NNS denotes layers
T24704 41558-41560 IN denotes of
T24705 41561-41572 NN denotes cheesecloth
T24706 41573-41574 -LRB- denotes (
T24707 41574-41580 NNP denotes Fisher
T24708 41580-41581 -RRB- denotes )
T24709 41582-41585 CC denotes and
T24710 41586-41592 VBN denotes frozen
T24711 41593-41595 IN denotes at
T24712 41596-41597 SYM denotes -
T24713 41597-41599 CD denotes 20
T24714 41599-41601 NN denotes °C
T24715 41602-41607 IN denotes until
T24716 41608-41616 NN denotes analysis
T24717 41616-41617 . denotes .
T24718 41617-41756 sentence denotes At this time, carcasses were freeze-dried for seven days and water content was determined by subtracting the freeze-dried weight from ECW.
T24719 41618-41620 IN denotes At
T24721 41621-41625 DT denotes this
T24722 41626-41630 NN denotes time
T24723 41630-41632 , denotes ,
T24724 41632-41641 NNS denotes carcasses
T24725 41642-41646 VBD denotes were
T24726 41647-41653 NN denotes freeze
T24727 41653-41654 HYPH denotes -
T24720 41654-41659 VBN denotes dried
T24728 41660-41663 IN denotes for
T24729 41664-41669 CD denotes seven
T24730 41670-41674 NNS denotes days
T24731 41675-41678 CC denotes and
T24732 41679-41684 NN denotes water
T24733 41685-41692 NN denotes content
T24735 41693-41696 VBD denotes was
T24734 41697-41707 VBN denotes determined
T24736 41708-41710 IN denotes by
T24737 41711-41722 VBG denotes subtracting
T24738 41723-41726 DT denotes the
T24740 41727-41733 NN denotes freeze
T24742 41733-41734 HYPH denotes -
T24741 41734-41739 VBN denotes dried
T24739 41740-41746 NN denotes weight
T24743 41747-41751 IN denotes from
T24744 41752-41755 NNP denotes ECW
T24745 41755-41756 . denotes .
T24746 41756-41871 sentence denotes FAT was then extracted with ether for 7 days, followed by acetone for an additional 7 days in a Soxhlet apparatus.
T24747 41757-41760 NN denotes FAT
T24749 41761-41764 VBD denotes was
T24750 41765-41769 RB denotes then
T24751 41770-41779 VBN denotes extracted
T24752 41780-41784 IN denotes with
T24753 41785-41790 NN denotes ether
T24754 41791-41794 IN denotes for
T24755 41795-41796 CD denotes 7
T24756 41797-41801 NNS denotes days
T24757 41801-41803 , denotes ,
T24748 41803-41811 VBN denotes followed
T24758 41812-41814 IN denotes by
T24759 41815-41822 NN denotes acetone
T24760 41823-41826 IN denotes for
T24761 41827-41829 DT denotes an
T24763 41830-41840 JJ denotes additional
T24764 41841-41842 CD denotes 7
T24762 41843-41847 NNS denotes days
T24765 41848-41850 IN denotes in
T24766 41851-41852 DT denotes a
T24768 41853-41860 NNP denotes Soxhlet
T24767 41861-41870 NN denotes apparatus
T24769 41870-41871 . denotes .
T24770 41871-41965 sentence denotes Carcass ash (ASH) was determined measuring the remains after a 16 hour incineration at 575°C.
T24771 41872-41879 NN denotes Carcass
T24772 41880-41883 NN denotes ash
T24774 41884-41885 -LRB- denotes (
T24775 41885-41888 NN denotes ASH
T24776 41888-41889 -RRB- denotes )
T24777 41890-41893 VBD denotes was
T24773 41894-41904 VBN denotes determined
T24778 41905-41914 VBG denotes measuring
T24779 41915-41918 DT denotes the
T24780 41919-41926 NNS denotes remains
T24781 41927-41932 IN denotes after
T24782 41933-41934 DT denotes a
T24784 41935-41937 CD denotes 16
T24785 41938-41942 NN denotes hour
T24783 41943-41955 NN denotes incineration
T24786 41956-41958 IN denotes at
T24787 41959-41962 CD denotes 575
T24788 41962-41964 NN denotes °C
T24789 41964-41965 . denotes .
T24790 41965-42086 sentence denotes Carcass protein (PROT) was calculated as the remaining portion after carcass fat (FAT) and ASH were subtracted from ECW.
T24791 41966-41973 NN denotes Carcass
T24792 41974-41981 NN denotes protein
T24794 41982-41983 -LRB- denotes (
T24795 41983-41987 NN denotes PROT
T24796 41987-41988 -RRB- denotes )
T24797 41989-41992 VBD denotes was
T24793 41993-42003 VBN denotes calculated
T24798 42004-42006 IN denotes as
T24799 42007-42010 DT denotes the
T24801 42011-42020 VBG denotes remaining
T24800 42021-42028 NN denotes portion
T24802 42029-42034 IN denotes after
T24804 42035-42042 NN denotes carcass
T24805 42043-42046 NN denotes fat
T24806 42047-42048 -LRB- denotes (
T24807 42048-42051 NN denotes FAT
T24808 42051-42052 -RRB- denotes )
T24809 42053-42056 CC denotes and
T24810 42057-42060 NN denotes ASH
T24811 42061-42065 VBD denotes were
T24803 42066-42076 VBN denotes subtracted
T24812 42077-42081 IN denotes from
T24813 42082-42085 NN denotes ECW
T24814 42085-42086 . denotes .
T25106 42088-42099 JJ denotes Statistical
T25107 42100-42108 NN denotes analysis
T25108 42108-42248 sentence denotes The MEANS and UNIVARIATE procedures of SAS were used to generate descriptive statistics and test normality assumptions for each trait [55].
T25109 42109-42112 DT denotes The
T25111 42113-42118 NN denotes MEANS
T25112 42119-42122 CC denotes and
T25113 42123-42133 NN denotes UNIVARIATE
T25110 42134-42144 NNS denotes procedures
T25115 42145-42147 IN denotes of
T25116 42148-42151 NNP denotes SAS
T25117 42152-42156 VBD denotes were
T25114 42157-42161 VBN denotes used
T25118 42162-42164 TO denotes to
T25119 42165-42173 VB denotes generate
T25120 42174-42185 JJ denotes descriptive
T25121 42186-42196 NNS denotes statistics
T25122 42197-42200 CC denotes and
T25123 42201-42205 VB denotes test
T25124 42206-42215 NN denotes normality
T25125 42216-42227 NNS denotes assumptions
T25126 42228-42231 IN denotes for
T25127 42232-42236 DT denotes each
T25128 42237-42242 NN denotes trait
T25129 42243-42244 -LRB- denotes [
T25130 42244-42246 CD denotes 55
T25131 42246-42247 -RRB- denotes ]
T25132 42247-42248 . denotes .
T25133 42248-42470 sentence denotes All data were then analyzed using the GLM procedure of SAS [55] with a linear model that included the fixed effects of strain, sex and strain by sex interaction; dam's weight at breeding by strain was used as a covariate.
T25134 42249-42252 DT denotes All
T25135 42253-42257 NNS denotes data
T25137 42258-42262 VBD denotes were
T25138 42263-42267 RB denotes then
T25136 42268-42276 VBN denotes analyzed
T25140 42277-42282 VBG denotes using
T25141 42283-42286 DT denotes the
T25143 42287-42290 NN denotes GLM
T25142 42291-42300 NN denotes procedure
T25144 42301-42303 IN denotes of
T25145 42304-42307 NN denotes SAS
T25146 42308-42309 -LRB- denotes [
T25147 42309-42311 CD denotes 55
T25148 42311-42312 -RRB- denotes ]
T25149 42313-42317 IN denotes with
T25150 42318-42319 DT denotes a
T25152 42320-42326 JJ denotes linear
T25151 42327-42332 NN denotes model
T25153 42333-42337 WDT denotes that
T25154 42338-42346 VBD denotes included
T25155 42347-42350 DT denotes the
T25157 42351-42356 VBN denotes fixed
T25156 42357-42364 NNS denotes effects
T25158 42365-42367 IN denotes of
T25159 42368-42374 NN denotes strain
T25160 42374-42376 , denotes ,
T25161 42376-42379 NN denotes sex
T25162 42380-42383 CC denotes and
T25163 42384-42390 NN denotes strain
T25165 42391-42393 IN denotes by
T25166 42394-42397 NN denotes sex
T25164 42398-42409 NN denotes interaction
T25167 42409-42410 : denotes ;
T25168 42411-42414 NN denotes dam
T25170 42414-42416 POS denotes 's
T25169 42417-42423 NN denotes weight
T25171 42424-42426 IN denotes at
T25172 42427-42435 NN denotes breeding
T25173 42436-42438 IN denotes by
T25174 42439-42445 NN denotes strain
T25175 42446-42449 VBD denotes was
T25139 42450-42454 VBN denotes used
T25176 42455-42457 IN denotes as
T25177 42458-42459 DT denotes a
T25178 42460-42469 NN denotes covariate
T25179 42469-42470 . denotes .
T25180 42470-42564 sentence denotes A second linear model was used to test for strain by hg genotype (+/+ or hg/hg) interactions.
T25181 42471-42472 DT denotes A
T25183 42473-42479 JJ denotes second
T25184 42480-42486 JJ denotes linear
T25182 42487-42492 NN denotes model
T25186 42493-42496 VBD denotes was
T25185 42497-42501 VBN denotes used
T25187 42502-42504 TO denotes to
T25188 42505-42509 VB denotes test
T25189 42510-42513 IN denotes for
T25190 42514-42520 NN denotes strain
T25192 42521-42523 IN denotes by
T25193 42524-42526 NN denotes hg
T25194 42527-42535 NN denotes genotype
T25195 42536-42537 -LRB- denotes (
T25197 42537-42538 SYM denotes +
T25198 42538-42539 HYPH denotes /
T25196 42539-42540 SYM denotes +
T25199 42541-42543 CC denotes or
T25200 42544-42546 NN denotes hg
T25202 42546-42547 HYPH denotes /
T25201 42547-42549 NN denotes hg
T25203 42549-42550 -RRB- denotes )
T25191 42551-42563 NNS denotes interactions
T25204 42563-42564 . denotes .
T25205 42564-42688 sentence denotes This model included the fixed effects of donor region, sex and HG genotype and all possible two and three-way interactions.
T25206 42565-42569 DT denotes This
T25207 42570-42575 NN denotes model
T25208 42576-42584 VBD denotes included
T25209 42585-42588 DT denotes the
T25211 42589-42594 VBN denotes fixed
T25210 42595-42602 NNS denotes effects
T25212 42603-42605 IN denotes of
T25213 42606-42611 NN denotes donor
T25214 42612-42618 NN denotes region
T25215 42618-42620 , denotes ,
T25216 42620-42623 NN denotes sex
T25217 42624-42627 CC denotes and
T25218 42628-42630 NN denotes HG
T25219 42631-42639 NN denotes genotype
T25220 42640-42643 CC denotes and
T25221 42644-42647 DT denotes all
T25223 42648-42656 JJ denotes possible
T25224 42657-42660 CD denotes two
T25226 42661-42664 CC denotes and
T25227 42665-42670 CD denotes three
T25228 42670-42671 HYPH denotes -
T25225 42671-42674 NN denotes way
T25222 42675-42687 NNS denotes interactions
T25229 42687-42688 . denotes .
T25230 42688-42839 sentence denotes Choosing a nominal P value of 0.05 and applying the Bonferroni correction for multiple comparisons established significant differences in the ANOVA's.
T25231 42689-42697 VBG denotes Choosing
T25233 42698-42699 DT denotes a
T25235 42700-42707 JJ denotes nominal
T25236 42708-42709 NN denotes P
T25234 42710-42715 NN denotes value
T25237 42716-42718 IN denotes of
T25238 42719-42723 CD denotes 0.05
T25239 42724-42727 CC denotes and
T25240 42728-42736 VBG denotes applying
T25241 42737-42740 DT denotes the
T25243 42741-42751 NNP denotes Bonferroni
T25242 42752-42762 NN denotes correction
T25244 42763-42766 IN denotes for
T25245 42767-42775 JJ denotes multiple
T25246 42776-42787 NNS denotes comparisons
T25232 42788-42799 VBD denotes established
T25247 42800-42811 JJ denotes significant
T25248 42812-42823 NNS denotes differences
T25249 42824-42826 IN denotes in
T25250 42827-42830 DT denotes the
T25251 42831-42836 NNP denotes ANOVA
T25252 42836-42838 AFX denotes 's
T25253 42838-42839 . denotes .
T25254 42839-42895 sentence denotes The critical P values used are indicated in each table.
T25255 42840-42843 DT denotes The
T25257 42844-42852 JJ denotes critical
T25258 42853-42854 NN denotes P
T25256 42855-42861 NNS denotes values
T25260 42862-42866 VBN denotes used
T25261 42867-42870 VBP denotes are
T25259 42871-42880 VBN denotes indicated
T25262 42881-42883 IN denotes in
T25263 42884-42888 DT denotes each
T25264 42889-42894 NN denotes table
T25265 42894-42895 . denotes .
T25440 42897-42911 NN denotes Identification
T25441 42912-42914 IN denotes of
T25442 42915-42924 NN denotes candidate
T25443 42925-42930 NNS denotes genes
T25444 42930-43024 sentence denotes Genes were identified by manual data mining of primary literature, reviews and book chapters.
T25445 42931-42936 NNS denotes Genes
T25447 42937-42941 VBD denotes were
T25446 42942-42952 VBN denotes identified
T25448 42953-42955 IN denotes by
T25449 42956-42962 JJ denotes manual
T25451 42963-42967 NNS denotes data
T25450 42968-42974 NN denotes mining
T25452 42975-42977 IN denotes of
T25453 42978-42985 JJ denotes primary
T25454 42986-42996 NN denotes literature
T25455 42996-42998 , denotes ,
T25456 42998-43005 NNS denotes reviews
T25457 43006-43009 CC denotes and
T25458 43010-43014 NN denotes book
T25459 43015-43023 NNS denotes chapters
T25460 43023-43024 . denotes .
T25461 43024-43205 sentence denotes To organize and collate genomic and functional information for each gene we created a custom Gh signaling Gene Map Annotator and Pathway Profiler (GenMAPP) pathway [56] (Figure 5).
T25462 43025-43027 TO denotes To
T25463 43028-43036 VB denotes organize
T25465 43037-43040 CC denotes and
T25466 43041-43048 VB denotes collate
T25467 43049-43056 JJ denotes genomic
T25469 43057-43060 CC denotes and
T25470 43061-43071 JJ denotes functional
T25468 43072-43083 NN denotes information
T25471 43084-43087 IN denotes for
T25472 43088-43092 DT denotes each
T25473 43093-43097 NN denotes gene
T25474 43098-43100 PRP denotes we
T25464 43101-43108 VBD denotes created
T25475 43109-43110 DT denotes a
T25477 43111-43117 NN denotes custom
T25478 43118-43120 NN denotes Gh
T25479 43121-43130 NN denotes signaling
T25480 43131-43135 NN denotes Gene
T25481 43136-43139 NN denotes Map
T25476 43140-43149 NN denotes Annotator
T25482 43150-43153 CC denotes and
T25483 43154-43161 NN denotes Pathway
T25484 43162-43170 NN denotes Profiler
T25486 43171-43172 -LRB- denotes (
T25487 43172-43179 NNP denotes GenMAPP
T25488 43179-43180 -RRB- denotes )
T25485 43181-43188 NN denotes pathway
T25489 43189-43190 -LRB- denotes [
T25490 43190-43192 CD denotes 56
T25491 43192-43193 -RRB- denotes ]
T25492 43194-43195 -LRB- denotes (
T25493 43195-43201 NN denotes Figure
T25494 43202-43203 CD denotes 5
T25495 43203-43204 -RRB- denotes )
T25496 43204-43205 . denotes .
T25497 43205-43348 sentence denotes Visualization and color-coding of genes using GenMAPP aided the selection of candidate genes mapping within QTL regions on MMU2, 9, 11 and 17.
T25498 43206-43219 NN denotes Visualization
T25500 43220-43223 CC denotes and
T25501 43224-43229 NN denotes color
T25502 43229-43230 HYPH denotes -
T25503 43230-43236 VBG denotes coding
T25504 43237-43239 IN denotes of
T25505 43240-43245 NNS denotes genes
T25506 43246-43251 VBG denotes using
T25507 43252-43259 NNP denotes GenMAPP
T25499 43260-43265 VBD denotes aided
T25508 43266-43269 DT denotes the
T25509 43270-43279 NN denotes selection
T25510 43280-43282 IN denotes of
T25511 43283-43292 NN denotes candidate
T25512 43293-43298 NNS denotes genes
T25513 43299-43306 VBG denotes mapping
T25514 43307-43313 IN denotes within
T25515 43314-43317 NNS denotes QTL
T25516 43318-43325 NNS denotes regions
T25517 43326-43328 IN denotes on
T25518 43329-43332 NN denotes MMU
T25519 43332-43333 CD denotes 2
T25520 43333-43335 , denotes ,
T25521 43335-43336 CD denotes 9
T25522 43336-43338 , denotes ,
T25523 43338-43340 CD denotes 11
T25524 43341-43344 CC denotes and
T25525 43345-43347 CD denotes 17
T25526 43347-43348 . denotes .
T26350 43350-43359 NN denotes Candidate
T26351 43360-43364 NN denotes gene
T26352 43365-43375 NN denotes sequencing
T26353 43375-43614 sentence denotes PCR amplicons covering the coding sequence and partial 5' and 3' untranslated regions for each selected candidate gene were amplified, purified and sequenced from the CAST strain using protocols outlined in [57] with slight modifications.
T26354 43376-43379 NN denotes PCR
T26355 43380-43389 NNS denotes amplicons
T26357 43390-43398 VBG denotes covering
T26358 43399-43402 DT denotes the
T26360 43403-43409 NN denotes coding
T26359 43410-43418 NN denotes sequence
T26361 43419-43422 CC denotes and
T26362 43423-43430 JJ denotes partial
T26364 43431-43432 CD denotes 5
T26365 43432-43433 SYM denotes '
T26366 43434-43437 CC denotes and
T26367 43438-43439 CD denotes 3
T26368 43439-43440 SYM denotes '
T26369 43441-43453 JJ denotes untranslated
T26363 43454-43461 NNS denotes regions
T26370 43462-43465 IN denotes for
T26371 43466-43470 DT denotes each
T26373 43471-43479 VBN denotes selected
T26374 43480-43489 NN denotes candidate
T26372 43490-43494 NN denotes gene
T26375 43495-43499 VBD denotes were
T26356 43500-43509 VBN denotes amplified
T26376 43509-43511 , denotes ,
T26377 43511-43519 VBN denotes purified
T26378 43520-43523 CC denotes and
T26379 43524-43533 VBN denotes sequenced
T26380 43534-43538 IN denotes from
T26381 43539-43542 DT denotes the
T26383 43543-43547 NN denotes CAST
T26382 43548-43554 NN denotes strain
T26384 43555-43560 VBG denotes using
T26385 43561-43570 NNS denotes protocols
T26386 43571-43579 VBN denotes outlined
T26387 43580-43582 IN denotes in
T26388 43583-43584 -LRB- denotes [
T26389 43584-43586 CD denotes 57
T26390 43586-43587 -RRB- denotes ]
T26391 43588-43592 IN denotes with
T26392 43593-43599 JJ denotes slight
T26393 43600-43613 NNS denotes modifications
T26394 43613-43614 . denotes .
T26395 43614-43733 sentence denotes Total RNA from brain, liver, spleen, lung and testis was isolated from an adult CAST male mouse using Trizol (Ambion).
T26396 43615-43620 JJ denotes Total
T26397 43621-43624 NN denotes RNA
T26399 43625-43629 IN denotes from
T26400 43630-43635 NN denotes brain
T26401 43635-43637 , denotes ,
T26402 43637-43642 NN denotes liver
T26403 43642-43644 , denotes ,
T26404 43644-43650 NN denotes spleen
T26405 43650-43652 , denotes ,
T26406 43652-43656 NN denotes lung
T26407 43657-43660 CC denotes and
T26408 43661-43667 NN denotes testis
T26409 43668-43671 VBD denotes was
T26398 43672-43680 VBN denotes isolated
T26410 43681-43685 IN denotes from
T26411 43686-43688 DT denotes an
T26413 43689-43694 JJ denotes adult
T26414 43695-43699 NN denotes CAST
T26415 43700-43704 JJ denotes male
T26412 43705-43710 NN denotes mouse
T26416 43711-43716 VBG denotes using
T26417 43717-43723 NN denotes Trizol
T26418 43724-43725 -LRB- denotes (
T26419 43725-43731 NNP denotes Ambion
T26420 43731-43732 -RRB- denotes )
T26421 43732-43733 . denotes .
T26422 43733-43793 sentence denotes cDNA was produced from total RNA using standard procedures.
T26423 43734-43738 NN denotes cDNA
T26425 43739-43742 VBD denotes was
T26424 43743-43751 VBN denotes produced
T26426 43752-43756 IN denotes from
T26427 43757-43762 JJ denotes total
T26428 43763-43766 NN denotes RNA
T26429 43767-43772 VBG denotes using
T26430 43773-43781 JJ denotes standard
T26431 43782-43792 NNS denotes procedures
T26432 43792-43793 . denotes .
T26433 43793-43877 sentence denotes PCR primer sets for each gene were designed using Primer3 [58] (Additional File 5).
T26434 43794-43797 NN denotes PCR
T26436 43798-43804 NN denotes primer
T26435 43805-43809 NNS denotes sets
T26438 43810-43813 IN denotes for
T26439 43814-43818 DT denotes each
T26440 43819-43823 NN denotes gene
T26441 43824-43828 VBD denotes were
T26437 43829-43837 VBN denotes designed
T26442 43838-43843 VBG denotes using
T26443 43844-43851 NN denotes Primer3
T26444 43852-43853 -LRB- denotes [
T26445 43853-43855 CD denotes 58
T26446 43855-43856 -RRB- denotes ]
T26447 43857-43858 -LRB- denotes (
T26449 43858-43868 JJ denotes Additional
T26448 43869-43873 NN denotes File
T26450 43874-43875 CD denotes 5
T26451 43875-43876 -RRB- denotes )
T26452 43876-43877 . denotes .
T26453 43877-44013 sentence denotes The initial amplification was performed in 10 μl PCR reactions using the Invitrogen Platinum TaqPCRx amplification system (Invitrogen).
T26454 43878-43881 DT denotes The
T26456 43882-43889 JJ denotes initial
T26455 43890-43903 NN denotes amplification
T26458 43904-43907 VBD denotes was
T26457 43908-43917 VBN denotes performed
T26459 43918-43920 IN denotes in
T26460 43921-43923 CD denotes 10
T26461 43924-43926 NN denotes μl
T26463 43927-43930 NN denotes PCR
T26462 43931-43940 NNS denotes reactions
T26464 43941-43946 VBG denotes using
T26465 43947-43950 DT denotes the
T26467 43951-43961 NNP denotes Invitrogen
T26468 43962-43970 NN denotes Platinum
T26469 43971-43978 NN denotes TaqPCRx
T26470 43979-43992 NN denotes amplification
T26466 43993-43999 NN denotes system
T26471 44000-44001 -LRB- denotes (
T26472 44001-44011 NNP denotes Invitrogen
T26473 44011-44012 -RRB- denotes )
T26474 44012-44013 . denotes .
T26475 44013-44192 sentence denotes The reactions contained 1X PCR buffer, 1X Enhancer solution, 1.5 mM MgSO4, 0.17 mM dNTPs, 1 μM each primer, 0.1 unit of Platinum Taq (Invitrogen) and approximately 25 ng of cDNA.
T26476 44014-44017 DT denotes The
T26477 44018-44027 NNS denotes reactions
T26478 44028-44037 VBD denotes contained
T26479 44038-44040 NN denotes 1X
T26481 44041-44044 NN denotes PCR
T26480 44045-44051 NN denotes buffer
T26482 44051-44053 , denotes ,
T26483 44053-44055 NN denotes 1X
T26485 44056-44064 NN denotes Enhancer
T26484 44065-44073 NN denotes solution
T26486 44073-44075 , denotes ,
T26487 44075-44078 CD denotes 1.5
T26488 44079-44081 NN denotes mM
T26489 44082-44087 NN denotes MgSO4
T26490 44087-44089 , denotes ,
T26491 44089-44093 CD denotes 0.17
T26492 44094-44096 NN denotes mM
T26493 44097-44102 NNS denotes dNTPs
T26494 44102-44104 , denotes ,
T26495 44104-44105 CD denotes 1
T26496 44106-44108 NN denotes μM
T26498 44109-44113 DT denotes each
T26497 44114-44120 NN denotes primer
T26499 44120-44122 , denotes ,
T26500 44122-44125 CD denotes 0.1
T26501 44126-44130 NN denotes unit
T26502 44131-44133 IN denotes of
T26503 44134-44142 NN denotes Platinum
T26504 44143-44146 NN denotes Taq
T26505 44147-44148 -LRB- denotes (
T26506 44148-44158 NNP denotes Invitrogen
T26507 44158-44159 -RRB- denotes )
T26508 44160-44163 CC denotes and
T26509 44164-44177 RB denotes approximately
T26510 44178-44180 CD denotes 25
T26511 44181-44183 NN denotes ng
T26512 44184-44186 IN denotes of
T26513 44187-44191 NN denotes cDNA
T26514 44191-44192 . denotes .
T26515 44192-44373 sentence denotes Reactions were incubated for 5 min at 95°C, then cycled for 45 s at 95°C, 45 s at 55°C, 1 min at 72°C for 35 cycles with a final 72°C extension for 10 min on a MJ Research PTC-200.
T26516 44193-44202 NNS denotes Reactions
T26518 44203-44207 VBD denotes were
T26517 44208-44217 VBN denotes incubated
T26519 44218-44221 IN denotes for
T26520 44222-44223 CD denotes 5
T26521 44224-44227 NN denotes min
T26522 44228-44230 IN denotes at
T26523 44231-44233 CD denotes 95
T26524 44233-44235 NN denotes °C
T26525 44235-44237 , denotes ,
T26526 44237-44241 RB denotes then
T26527 44242-44248 VBN denotes cycled
T26528 44249-44252 IN denotes for
T26529 44253-44255 CD denotes 45
T26530 44256-44257 NN denotes s
T26531 44258-44260 IN denotes at
T26532 44261-44263 CD denotes 95
T26533 44263-44265 NN denotes °C
T26534 44265-44267 , denotes ,
T26535 44267-44269 CD denotes 45
T26536 44270-44271 NN denotes s
T26537 44272-44274 IN denotes at
T26538 44275-44277 CD denotes 55
T26539 44277-44279 NN denotes °C
T26540 44279-44281 , denotes ,
T26541 44281-44282 CD denotes 1
T26542 44283-44286 NN denotes min
T26543 44287-44289 IN denotes at
T26544 44290-44292 CD denotes 72
T26545 44292-44294 NN denotes °C
T26546 44295-44298 IN denotes for
T26547 44299-44301 CD denotes 35
T26548 44302-44308 NNS denotes cycles
T26549 44309-44313 IN denotes with
T26550 44314-44315 DT denotes a
T26552 44316-44321 JJ denotes final
T26553 44322-44324 CD denotes 72
T26554 44324-44326 NN denotes °C
T26551 44327-44336 NN denotes extension
T26555 44337-44340 IN denotes for
T26556 44341-44343 CD denotes 10
T26557 44344-44347 NN denotes min
T26558 44348-44350 IN denotes on
T26559 44351-44352 DT denotes a
T26561 44353-44355 NNP denotes MJ
T26562 44356-44364 NNP denotes Research
T26560 44365-44368 NNP denotes PTC
T26563 44368-44369 HYPH denotes -
T26564 44369-44372 CD denotes 200
T26565 44372-44373 . denotes .
T26566 44373-44451 sentence denotes The products were visualized on 1.5% agarose gels containing 0.06 μg/ml EtBr.
T26567 44374-44377 DT denotes The
T26568 44378-44386 NNS denotes products
T26570 44387-44391 VBD denotes were
T26569 44392-44402 VBN denotes visualized
T26571 44403-44405 IN denotes on
T26572 44406-44409 CD denotes 1.5
T26573 44409-44410 NN denotes %
T26574 44411-44418 NN denotes agarose
T26575 44419-44423 NNS denotes gels
T26576 44424-44434 VBG denotes containing
T26577 44435-44439 CD denotes 0.06
T26578 44440-44442 NN denotes μg
T26580 44442-44443 SYM denotes /
T26581 44443-44445 NN denotes ml
T26579 44446-44450 NN denotes EtBr
T26582 44450-44451 . denotes .
T26583 44451-44562 sentence denotes Bands of the correct size were excised and incubated in 100 μl of sterile H2O at 80°C for 10 min to elute DNA.
T26584 44452-44457 NNS denotes Bands
T26586 44458-44460 IN denotes of
T26587 44461-44464 DT denotes the
T26589 44465-44472 JJ denotes correct
T26588 44473-44477 NN denotes size
T26590 44478-44482 VBD denotes were
T26585 44483-44490 VBN denotes excised
T26591 44491-44494 CC denotes and
T26592 44495-44504 VBN denotes incubated
T26593 44505-44507 IN denotes in
T26594 44508-44511 CD denotes 100
T26595 44512-44514 NN denotes μl
T26596 44515-44517 IN denotes of
T26597 44518-44525 JJ denotes sterile
T26598 44526-44529 NN denotes H2O
T26599 44530-44532 IN denotes at
T26600 44533-44535 CD denotes 80
T26601 44535-44537 NN denotes °C
T26602 44538-44541 IN denotes for
T26603 44542-44544 CD denotes 10
T26604 44545-44548 NN denotes min
T26605 44549-44551 TO denotes to
T26606 44552-44557 VB denotes elute
T26607 44558-44561 NN denotes DNA
T26608 44561-44562 . denotes .
T26609 44562-44737 sentence denotes Reamplification reactions consisted of 1X PCR buffer, 1.5 mM MgCl2, 0.17 mM dNTPs, 1 μM each primer, 0.1 unit of Taq (Promega) and 10 μl of eluate in a total volume of 50 μl.
T26610 44563-44578 NN denotes Reamplification
T26611 44579-44588 NNS denotes reactions
T26612 44589-44598 VBD denotes consisted
T26613 44599-44601 IN denotes of
T26614 44602-44604 NN denotes 1X
T26616 44605-44608 NN denotes PCR
T26615 44609-44615 NN denotes buffer
T26617 44615-44617 , denotes ,
T26618 44617-44620 CD denotes 1.5
T26619 44621-44623 NN denotes mM
T26620 44624-44629 NN denotes MgCl2
T26621 44629-44631 , denotes ,
T26622 44631-44635 CD denotes 0.17
T26623 44636-44638 NN denotes mM
T26624 44639-44644 NNS denotes dNTPs
T26625 44644-44646 , denotes ,
T26626 44646-44647 CD denotes 1
T26627 44648-44650 NN denotes μM
T26629 44651-44655 DT denotes each
T26628 44656-44662 NN denotes primer
T26630 44662-44664 , denotes ,
T26631 44664-44667 CD denotes 0.1
T26632 44668-44672 NN denotes unit
T26633 44673-44675 IN denotes of
T26634 44676-44679 NN denotes Taq
T26635 44680-44681 -LRB- denotes (
T26636 44681-44688 NNP denotes Promega
T26637 44688-44689 -RRB- denotes )
T26638 44690-44693 CC denotes and
T26639 44694-44696 CD denotes 10
T26640 44697-44699 NN denotes μl
T26641 44700-44702 IN denotes of
T26642 44703-44709 NN denotes eluate
T26643 44710-44712 IN denotes in
T26644 44713-44714 DT denotes a
T26646 44715-44720 JJ denotes total
T26645 44721-44727 NN denotes volume
T26647 44728-44730 IN denotes of
T26648 44731-44733 CD denotes 50
T26649 44734-44736 NN denotes μl
T26650 44736-44737 . denotes .
T26651 44737-44806 sentence denotes The same cycling parameters were used for reamplification reactions.
T26652 44738-44741 DT denotes The
T26654 44742-44746 JJ denotes same
T26655 44747-44754 NN denotes cycling
T26653 44755-44765 NNS denotes parameters
T26657 44766-44770 VBD denotes were
T26656 44771-44775 VBN denotes used
T26658 44776-44779 IN denotes for
T26659 44780-44795 NN denotes reamplification
T26660 44796-44805 NNS denotes reactions
T26661 44805-44806 . denotes .
T26662 44806-44949 sentence denotes Products were visualized on 1% 0.5X TBE agarose gels containing 0.06 μg/ml EtBr, excised and purfied using PCR purification columns (Promega).
T26663 44807-44815 NNS denotes Products
T26665 44816-44820 VBD denotes were
T26664 44821-44831 VBN denotes visualized
T26666 44832-44834 IN denotes on
T26667 44835-44836 CD denotes 1
T26668 44836-44837 NN denotes %
T26670 44838-44842 NN denotes 0.5X
T26671 44843-44846 NN denotes TBE
T26672 44847-44854 NN denotes agarose
T26669 44855-44859 NNS denotes gels
T26673 44860-44870 VBG denotes containing
T26674 44871-44875 CD denotes 0.06
T26675 44876-44878 NN denotes μg
T26677 44878-44879 SYM denotes /
T26678 44879-44881 NN denotes ml
T26676 44882-44886 NN denotes EtBr
T26679 44886-44888 , denotes ,
T26680 44888-44895 VBN denotes excised
T26681 44896-44899 CC denotes and
T26682 44900-44907 VBN denotes purfied
T26683 44908-44913 VBG denotes using
T26684 44914-44917 NN denotes PCR
T26685 44918-44930 NN denotes purification
T26686 44931-44938 NNS denotes columns
T26687 44939-44940 -LRB- denotes (
T26688 44940-44947 NNP denotes Promega
T26689 44947-44948 -RRB- denotes )
T26690 44948-44949 . denotes .
T26691 44949-45106 sentence denotes To quantity each fragment 1 μl of each purified product was run on a 1.0% agarose gel containing 0.06 μg/ml EtBr, along with a DNA mass ladder (Invitrogen).
T26692 44950-44952 TO denotes To
T26693 44953-44961 VB denotes quantity
T26695 44962-44966 DT denotes each
T26696 44967-44975 NN denotes fragment
T26697 44976-44977 CD denotes 1
T26698 44978-44980 NN denotes μl
T26699 44981-44983 IN denotes of
T26700 44984-44988 DT denotes each
T26702 44989-44997 VBN denotes purified
T26701 44998-45005 NN denotes product
T26703 45006-45009 VBD denotes was
T26694 45010-45013 VBN denotes run
T26704 45014-45016 IN denotes on
T26705 45017-45018 DT denotes a
T26707 45019-45022 CD denotes 1.0
T26708 45022-45023 NN denotes %
T26709 45024-45031 NN denotes agarose
T26706 45032-45035 NN denotes gel
T26710 45036-45046 VBG denotes containing
T26711 45047-45051 CD denotes 0.06
T26712 45052-45054 NN denotes μg
T26714 45054-45055 SYM denotes /
T26715 45055-45057 NN denotes ml
T26713 45058-45062 NN denotes EtBr
T26716 45062-45064 , denotes ,
T26717 45064-45069 IN denotes along
T26718 45070-45074 IN denotes with
T26719 45075-45076 DT denotes a
T26721 45077-45080 NN denotes DNA
T26722 45081-45085 NN denotes mass
T26720 45086-45092 NN denotes ladder
T26723 45093-45094 -LRB- denotes (
T26724 45094-45104 NNP denotes Invitrogen
T26725 45104-45105 -RRB- denotes )
T26726 45105-45106 . denotes .
T26727 45106-45196 sentence denotes In a 96 well plate, 15 ng of each PCR product was added to 5 pM of primer for sequencing.
T26728 45107-45109 IN denotes In
T26730 45110-45111 DT denotes a
T26732 45112-45114 CD denotes 96
T26733 45115-45119 NN denotes well
T26731 45120-45125 NN denotes plate
T26734 45125-45127 , denotes ,
T26735 45127-45129 CD denotes 15
T26736 45130-45132 NN denotes ng
T26737 45133-45135 IN denotes of
T26738 45136-45140 DT denotes each
T26740 45141-45144 NN denotes PCR
T26739 45145-45152 NN denotes product
T26741 45153-45156 VBD denotes was
T26729 45157-45162 VBN denotes added
T26742 45163-45165 IN denotes to
T26743 45166-45167 CD denotes 5
T26744 45168-45170 NN denotes pM
T26745 45171-45173 IN denotes of
T26746 45174-45180 NN denotes primer
T26747 45181-45184 IN denotes for
T26748 45185-45195 NN denotes sequencing
T26749 45195-45196 . denotes .
T26750 45196-45368 sentence denotes The College of Agriculture and Environmental Sciences (CAES) Genomics Facility at the University of California, Davis, performed bidirectional sequencing of each amplicon.
T26751 45197-45200 DT denotes The
T26752 45201-45208 NNP denotes College
T26754 45209-45211 IN denotes of
T26755 45212-45223 NNP denotes Agriculture
T26757 45224-45227 CC denotes and
T26758 45228-45241 NNP denotes Environmental
T26756 45242-45250 NNPS denotes Sciences
T26759 45251-45252 -LRB- denotes (
T26760 45252-45256 NNP denotes CAES
T26761 45256-45257 -RRB- denotes )
T26762 45258-45266 NNP denotes Genomics
T26753 45267-45275 NN denotes Facility
T26764 45276-45278 IN denotes at
T26765 45279-45282 DT denotes the
T26766 45283-45293 NNP denotes University
T26767 45294-45296 IN denotes of
T26768 45297-45307 NNP denotes California
T26769 45307-45309 , denotes ,
T26770 45309-45314 NNP denotes Davis
T26771 45314-45316 , denotes ,
T26763 45316-45325 VBD denotes performed
T26772 45326-45339 JJ denotes bidirectional
T26773 45340-45350 NN denotes sequencing
T26774 45351-45353 IN denotes of
T26775 45354-45358 DT denotes each
T26776 45359-45367 NN denotes amplicon
T26777 45367-45368 . denotes .
T26935 45370-45378 NN denotes Sequence
T26936 45379-45387 NN denotes analysis
T26937 45387-45502 sentence denotes B6 mRNA sequences for each gene were downloaded from the May 2004 (mm5) UCSC (NCBI Build 33) genome assembly [28].
T26938 45388-45390 NN denotes B6
T26940 45391-45395 NN denotes mRNA
T26939 45396-45405 NNS denotes sequences
T26942 45406-45409 IN denotes for
T26943 45410-45414 DT denotes each
T26944 45415-45419 NN denotes gene
T26945 45420-45424 VBD denotes were
T26941 45425-45435 VBN denotes downloaded
T26946 45436-45440 IN denotes from
T26947 45441-45444 DT denotes the
T26949 45445-45448 NNP denotes May
T26950 45449-45453 CD denotes 2004
T26951 45454-45455 -LRB- denotes (
T26952 45455-45458 NN denotes mm5
T26953 45458-45459 -RRB- denotes )
T26954 45460-45464 NNP denotes UCSC
T26955 45465-45466 -LRB- denotes (
T26957 45466-45470 NNP denotes NCBI
T26956 45471-45476 NNP denotes Build
T26958 45477-45479 CD denotes 33
T26959 45479-45480 -RRB- denotes )
T26960 45481-45487 NN denotes genome
T26948 45488-45496 NN denotes assembly
T26961 45497-45498 -LRB- denotes [
T26962 45498-45500 CD denotes 28
T26963 45500-45501 -RRB- denotes ]
T26964 45501-45502 . denotes .
T26965 45502-45654 sentence denotes These sequences were imported along with all CAST sequence traces into the SeqMan sequence assembly program (DNASTAR) and manually curated for quality.
T26966 45503-45508 DT denotes These
T26967 45509-45518 NNS denotes sequences
T26969 45519-45523 VBD denotes were
T26968 45524-45532 VBN denotes imported
T26970 45533-45538 IN denotes along
T26971 45539-45543 IN denotes with
T26972 45544-45547 DT denotes all
T26974 45548-45552 NN denotes CAST
T26975 45553-45561 NN denotes sequence
T26973 45562-45568 NNS denotes traces
T26976 45569-45573 IN denotes into
T26977 45574-45577 DT denotes the
T26979 45578-45584 NNP denotes SeqMan
T26980 45585-45593 NN denotes sequence
T26981 45594-45602 NN denotes assembly
T26978 45603-45610 NN denotes program
T26982 45611-45612 -LRB- denotes (
T26983 45612-45619 NNP denotes DNASTAR
T26984 45619-45620 -RRB- denotes )
T26985 45621-45624 CC denotes and
T26986 45625-45633 RB denotes manually
T26987 45634-45641 VBN denotes curated
T26988 45642-45645 IN denotes for
T26989 45646-45653 NN denotes quality
T26990 45653-45654 . denotes .
T26991 45654-45691 sentence denotes Poor quality reads were resequenced.
T26992 45655-45659 JJ denotes Poor
T26993 45660-45667 NN denotes quality
T26994 45668-45673 NNS denotes reads
T26996 45674-45678 VBD denotes were
T26995 45679-45690 VBN denotes resequenced
T26997 45690-45691 . denotes .
T26998 45691-45803 sentence denotes Individual contigs were created for each gene and polymorphisms were detected and curated by manual inspection.
T26999 45692-45702 JJ denotes Individual
T27000 45703-45710 NNS denotes contigs
T27002 45711-45715 VBD denotes were
T27001 45716-45723 VBN denotes created
T27003 45724-45727 IN denotes for
T27004 45728-45732 DT denotes each
T27005 45733-45737 NN denotes gene
T27006 45738-45741 CC denotes and
T27007 45742-45755 NNS denotes polymorphisms
T27009 45756-45760 VBD denotes were
T27008 45761-45769 VBN denotes detected
T27010 45770-45773 CC denotes and
T27011 45774-45781 VBN denotes curated
T27012 45782-45784 IN denotes by
T27013 45785-45791 JJ denotes manual
T27014 45792-45802 NN denotes inspection
T27015 45802-45803 . denotes .
R1 T574 T577 amod wide,isolation
R10 T585 T586 npadvmod speed,congenic
R100 T682 T680 appos 6J,type
R1000 T3473 T3472 prep on,Carfhg1
R1001 T3474 T3473 pobj MMU5,on
R1002 T3547 T3545 pobj strains,of
R1003 T3475 T3472 punct ", ",Carfhg1
R1004 T3476 T3472 conj Wg3,Carfhg1
R1005 T3477 T3476 prep on,Wg3
R1006 T3548 T3547 prep with,strains
R1007 T3478 T3477 pobj MMU8,on
R1008 T3479 T3476 punct ", ",Wg3
R1009 T3480 T3476 conj Feml2,Wg3
R101 T683 T682 punct /,6J
R1010 T3481 T3480 prep on,Feml2
R1011 T3482 T3481 pobj MMU9,on
R1012 T3483 T3480 punct ", ",Feml2
R1013 T3549 T3550 amod identical,regions
R1014 T3484 T3480 conj Wg4,Feml2
R1015 T3485 T3484 cc and,Wg4
R1016 T3486 T3484 conj Cara2,Wg4
R1017 T3550 T3548 pobj regions,with
R1018 T3487 T3484 prep on,Wg4
R1019 T3488 T3487 pobj MMU11,on
R102 T684 T685 punct (,B6
R1020 T3489 T3484 cc and,Wg4
R1021 T3490 T3484 conj Carp3,Wg4
R1022 T3551 T3550 compound donor,regions
R1023 T3491 T3490 cc and,Carp3
R1024 T3492 T3490 conj Cara3,Carp3
R1025 T3552 T3543 prep on,panel
R1026 T3493 T3490 prep on,Carp3
R1027 T3494 T3493 pobj MMU17,on
R1028 T3495 T3490 punct ),Carp3
R1029 T3553 T3554 preconj both,B6
R103 T685 T680 parataxis B6,type
R1030 T3554 T3555 nmod B6,backgrounds
R1031 T3496 T3497 poss whose,expression
R1032 T3555 T3552 pobj backgrounds,on
R1033 T3497 T3498 dep expression,was
R1034 T3498 T3490 relcl was,Carp3
R1035 T3499 T3498 acomp independent,was
R1036 T3556 T3554 cc and,B6
R1037 T3500 T3499 prep of,independent
R1038 T3501 T3502 det the,locus
R1039 T3502 T3500 pobj locus,of
R104 T686 T685 punct ),B6
R1040 T3557 T3554 conj HG,B6
R1041 T3503 T3502 compound hg,locus
R1042 T3504 T3421 punct .,identified
R1043 T3558 T3541 auxpass were,developed
R1044 T3506 T3507 prep In,developed
R1045 T3559 T3541 prep for,developed
R1046 T3508 T3509 det the,study
R1047 T3509 T3506 pobj study,In
R1048 T3510 T3509 amod current,study
R1049 T3511 T3507 nsubj we,developed
R105 T687 T674 amod genetic,backgrounds
R1050 T3560 T3559 pobj MMU2,for
R1051 T3512 T3507 aux have,developed
R1052 T3513 T3514 npadvmod speed,congenic
R1053 T3514 T3515 amod congenic,strains
R1054 T3561 T3526 punct .,created
R1055 T3515 T3507 dobj strains,developed
R1056 T3516 T3517 aux to,isolate
R1057 T3517 T3507 advcl isolate,developed
R1058 T3563 T3564 det The,panel
R1059 T3518 T3519 predet all,QTL
R106 T688 T640 punct .,developed
R1060 T3519 T3517 dobj QTL,isolate
R1061 T3520 T3519 det the,QTL
R1062 T3521 T3519 amod aforementioned,QTL
R1063 T3522 T3507 punct .,developed
R1064 T3524 T3525 amod Single,strains
R1065 T3564 T3566 nsubjpass panel,developed
R1066 T3525 T3526 nsubjpass strains,created
R1067 T3527 T3525 prep on,strains
R1068 T3565 T3564 compound MMU2,panel
R1069 T3528 T3529 det an,background
R107 T692 T693 det The,panel
R1070 T3529 T3527 pobj background,on
R1071 T3530 T3529 compound HG,background
R1072 T3567 T3566 auxpass was,developed
R1073 T3531 T3526 auxpass were,created
R1074 T3532 T3526 prep for,created
R1075 T3568 T3569 aux to,confirm
R1076 T3533 T3534 det each,region
R1077 T3569 T3566 advcl confirm,developed
R1078 T3534 T3532 pobj region,for
R1079 T3535 T3534 amod chromosomal,region
R108 T693 T697 nsubjpass panel,developed
R1080 T3536 T3534 prep outside,region
R1081 T3570 T3571 det the,presence
R1082 T3571 T3569 dobj presence,confirm
R1083 T3572 T3571 prep of,presence
R1084 T3573 T3574 amod multiple,QTL
R1085 T3574 T3572 pobj QTL,of
R1086 T3575 T3569 cc and,confirm
R1087 T3576 T3569 conj test,confirm
R1088 T3577 T3576 prep for,test
R1089 T3578 T3579 compound QTL,hg
R109 T694 T693 amod first,panel
R1090 T3579 T3581 compound hg,interactions
R1091 T3580 T3579 punct -,hg
R1092 T3581 T3577 pobj interactions,for
R1093 T3582 T3566 punct .,developed
R1094 T3584 T3585 advmod Additionally,sequenced
R1095 T3586 T3585 punct ", ",sequenced
R1096 T3587 T3585 prep based,sequenced
R1097 T3588 T3587 prep on,based
R1098 T3589 T3590 det the,knowledge
R1099 T3590 T3588 pobj knowledge,on
R11 T586 T587 amod congenic,strains
R110 T695 T696 npadvmod speed,congenic
R1100 T3591 T3590 prep of,knowledge
R1101 T3592 T3593 amod potential,interactions
R1102 T3593 T3591 pobj interactions,of
R1103 T3594 T3595 compound QTL,hg
R1104 T3595 T3593 compound hg,interactions
R1105 T3596 T3595 punct -,hg
R1106 T3597 T3585 punct ", ",sequenced
R1107 T3598 T3585 nsubjpass genes,sequenced
R1108 T3599 T3598 acl involved,genes
R1109 T3600 T3599 prep in,involved
R111 T696 T693 amod congenic,panel
R1110 T3601 T3602 compound Gh,signaling
R1111 T3602 T3600 pobj signaling,in
R1112 T3603 T3598 punct ", ",genes
R1113 T3604 T3605 poss whose,location
R1114 T3605 T3607 dep location,overlapped
R1115 T3606 T3605 amod genomic,location
R1116 T3607 T3598 relcl overlapped,genes
R1117 T3608 T3609 compound hg,QTL
R1118 T3609 T3607 dobj QTL,overlapped
R1119 T3610 T3609 compound modifier,QTL
R112 T698 T697 auxpass was,developed
R1120 T3611 T3609 prep on,QTL
R1121 T3612 T3613 nmod MMU,2
R1122 T3613 T3611 pobj 2,on
R1123 T3614 T3613 punct ", ",2
R1124 T3615 T3613 conj 9,2
R1125 T3616 T3615 punct ", ",9
R1126 T3617 T3615 conj 11,9
R1127 T3618 T3617 cc and,11
R1128 T3619 T3617 conj 17,11
R1129 T3620 T3585 punct ", ",sequenced
R113 T699 T697 prep by,developed
R1130 T3621 T3585 auxpass were,sequenced
R1131 T3622 T3585 punct .,sequenced
R1132 T4080 T4081 npadvmod Speed,congenic
R1133 T4081 T4082 amod congenic,strain
R1134 T4082 T4083 compound strain,development
R1135 T4085 T4086 nummod Two,panels
R1136 T4086 T4089 nsubjpass panels,created
R1137 T4087 T4088 npadvmod speed,congenic
R1138 T4088 T4086 amod congenic,panels
R1139 T4090 T4089 auxpass were,created
R114 T700 T699 pcomp introgressing,by
R1140 T4091 T4089 punct ", ",created
R1141 T4092 T4093 det the,first
R1142 T4093 T4094 nsubj first,dissected
R1143 T4094 T4089 advcl dissected,created
R1144 T4095 T4094 advmod comprehensively,dissected
R1145 T4096 T4094 dobj MMU2,dissected
R1146 T4097 T4098 mark while,isolated
R1147 T4098 T4094 advcl isolated,dissected
R1148 T4099 T4100 det the,second
R1149 T4100 T4098 nsubj second,isolated
R115 T701 T702 nummod four,regions
R1150 T4101 T4098 dobj QTL,isolated
R1151 T4102 T4098 prep on,isolated
R1152 T4103 T4104 nmod MMU,1
R1153 T4104 T4102 pobj 1,on
R1154 T4105 T4104 punct ", ",1
R1155 T4106 T4104 conj 5,1
R1156 T4107 T4106 punct ", ",5
R1157 T4108 T4106 conj 8,5
R1158 T4109 T4108 punct ", ",8
R1159 T4110 T4108 conj 9,8
R116 T702 T700 dobj regions,introgressing
R1160 T4111 T4110 punct ", ",9
R1161 T4112 T4110 conj 11,9
R1162 T4113 T4112 cc and,11
R1163 T4114 T4112 conj 17,11
R1164 T4115 T4116 punct (,Table
R1165 T4116 T4098 parataxis Table,isolated
R1166 T4117 T4116 nummod 1,Table
R1167 T4118 T4116 punct ),Table
R1168 T4119 T4089 punct .,created
R1169 T4121 T4122 det The,panel
R117 T703 T702 amod overlapping,regions
R1170 T4122 T4124 nsubj panel,consisted
R1171 T4123 T4122 compound MMU2,panel
R1172 T4125 T4124 prep of,consisted
R1173 T4126 T4127 nummod eight,strains
R1174 T4127 T4125 pobj strains,of
R1175 T4128 T4127 amod congenic,strains
R1176 T4129 T4127 acl developed,strains
R1177 T4130 T4129 prep by,developed
R1178 T4131 T4130 pcomp introgressing,by
R1179 T4132 T4133 nummod four,regions
R118 T704 T702 compound donor,regions
R1180 T4133 T4131 dobj regions,introgressing
R1181 T4134 T4133 amod overlapping,regions
R1182 T4135 T4133 compound donor,regions
R1183 T4136 T4131 prep onto,introgressing
R1184 T4137 T4138 preconj both,B6
R1185 T4138 T4139 nmod B6,backgrounds
R1186 T4139 T4136 pobj backgrounds,onto
R1187 T4140 T4138 cc and,B6
R1188 T4141 T4138 conj HG,B6
R1189 T4142 T4139 amod genetic,backgrounds
R119 T705 T702 acl spanning,regions
R1190 T4143 T4144 punct (,Table
R1191 T4144 T4129 parataxis Table,developed
R1192 T4145 T4144 nummod 1,Table
R1193 T4146 T4144 punct ),Table
R1194 T4147 T4124 punct .,consisted
R1195 T4149 T4150 amod Single,regions
R1196 T4150 T4152 nsubjpass regions,created
R1197 T4151 T4150 compound donor,regions
R1198 T4153 T4150 acl bred,regions
R1199 T4154 T4153 prep onto,bred
R12 T587 T583 dobj strains,using
R120 T706 T705 dobj MMU2,spanning
R1200 T4155 T4156 det an,background
R1201 T4156 T4154 pobj background,onto
R1202 T4157 T4156 compound HG,background
R1203 T4158 T4152 auxpass were,created
R1204 T4159 T4160 aux to,isolate
R1205 T4160 T4152 advcl isolate,created
R1206 T4161 T4162 det the,QTL
R1207 T4162 T4160 dobj QTL,isolate
R1208 T4163 T4162 amod remaining,QTL
R1209 T4164 T4162 prep on,QTL
R121 T707 T706 prep in,MMU2
R1210 T4165 T4166 nmod MMU,1
R1211 T4166 T4164 pobj 1,on
R1212 T4167 T4166 punct ", ",1
R1213 T4168 T4166 conj 5,1
R1214 T4169 T4168 punct ", ",5
R1215 T4170 T4168 conj 8,5
R1216 T4171 T4170 punct ", ",8
R1217 T4172 T4170 conj 9,8
R1218 T4173 T4172 punct ", ",9
R1219 T4174 T4172 conj 11,9
R122 T708 T709 poss its,entirety
R1220 T4175 T4174 cc and,11
R1221 T4176 T4174 conj 17,11
R1222 T4177 T4152 punct .,created
R1223 T4179 T4180 nsubj Implementation,accelerated
R1224 T4181 T4179 prep of,Implementation
R1225 T4182 T4183 det a,approach
R1226 T4183 T4181 pobj approach,of
R1227 T4184 T4185 npadvmod speed,congenic
R1228 T4185 T4183 amod congenic,approach
R1229 T4186 T4179 acl using,Implementation
R123 T709 T707 pobj entirety,in
R1230 T4187 T4188 npadvmod marker,assisted
R1231 T4188 T4190 amod assisted,breeding
R1232 T4189 T4188 punct -,assisted
R1233 T4190 T4186 dobj breeding,using
R1234 T4191 T4186 prep with,using
R1235 T4192 T4193 nummod 79,markers
R1236 T4193 T4191 pobj markers,with
R1237 T4194 T4195 npadvmod genome,wide
R1238 T4195 T4193 amod wide,markers
R1239 T4196 T4195 punct -,wide
R124 T710 T700 prep onto,introgressing
R1240 T4197 T4193 compound microsatellite,markers
R1241 T4198 T4180 dobj production,accelerated
R1242 T4199 T4198 prep of,production
R1243 T4200 T4201 det all,strains
R1244 T4201 T4199 pobj strains,of
R1245 T4202 T4203 punct [,6
R1246 T4203 T4180 parataxis 6,accelerated
R1247 T4204 T4203 nummod 5,6
R1248 T4205 T4203 punct ",",6
R1249 T4206 T4203 punct ],6
R125 T711 T712 preconj both,HG
R1250 T4207 T4208 punct (,File
R1251 T4208 T4180 parataxis File,accelerated
R1252 T4209 T4208 amod Additional,File
R1253 T4210 T4208 nummod 1,File
R1254 T4211 T4208 cc and,File
R1255 T4212 T4208 conj Figure,File
R1256 T4213 T4212 nummod 1,Figure
R1257 T4214 T4208 punct ),File
R1258 T4215 T4180 punct .,accelerated
R1259 T4217 T4218 compound Strain,abbreviations
R126 T712 T713 nmod HG,backgrounds
R1260 T4218 T4219 nsubjpass abbreviations,listed
R1261 T4220 T4218 cc and,abbreviations
R1262 T4221 T4222 amod genomic,region
R1263 T4222 T4218 conj region,abbreviations
R1264 T4223 T4222 acl isolated,region
R1265 T4224 T4223 prep by,isolated
R1266 T4225 T4226 det each,strain
R1267 T4226 T4224 pobj strain,by
R1268 T4227 T4219 auxpass are,listed
R1269 T4228 T4219 prep in,listed
R127 T713 T710 pobj backgrounds,onto
R1270 T4229 T4228 pobj Table,in
R1271 T4230 T4229 nummod 1,Table
R1272 T4231 T4219 punct .,listed
R1273 T4233 T4234 prep In,developed
R1274 T4235 T4233 pobj addition,In
R1275 T4236 T4235 prep to,addition
R1276 T4237 T4238 preconj both,panels
R1277 T4238 T4236 pobj panels,to
R1278 T4239 T4238 amod congenic,panels
R1279 T4240 T4234 punct ", ",developed
R128 T714 T712 cc and,HG
R1280 T4241 T4242 nummod two,strains
R1281 T4242 T4234 nsubjpass strains,developed
R1282 T4243 T4242 compound control,strains
R1283 T4244 T4245 amod homozygous,B6
R1284 T4245 T4242 appos B6,strains
R1285 T4246 T4245 punct (,B6
R1286 T4247 T4248 nmod B6.CASTC,B6C
R1287 T4248 T4245 appos B6C,B6
R1288 T4249 T4248 punct ;,B6C
R1289 T4250 T4245 punct ),B6
R129 T715 T712 conj B6,HG
R1290 T4251 T4245 cc or,B6
R1291 T4252 T4245 conj HG,B6
R1292 T4253 T4252 punct (,HG
R1293 T4254 T4255 nmod HG.CASTC,HGC
R1294 T4255 T4252 appos HGC,HG
R1295 T4256 T4255 punct ;,HGC
R1296 T4257 T4245 punct ),B6
R1297 T4258 T4245 prep for,B6
R1298 T4259 T4260 det all,markers
R1299 T4260 T4258 pobj markers,for
R13 T592 T593 amod High,growth
R130 T716 T700 punct ", ",introgressing
R1300 T4261 T4262 npadvmod genome,wide
R1301 T4262 T4260 amod wide,markers
R1302 T4263 T4262 punct -,wide
R1303 T4264 T4242 acl genotyped,strains
R1304 T4265 T4234 auxpass were,developed
R1305 T4266 T4234 prep from,developed
R1306 T4267 T4268 det the,cross
R1307 T4268 T4266 pobj cross,from
R1308 T4269 T4268 amod same,cross
R1309 T4270 T4234 punct (,developed
R131 T717 T700 prep for,introgressing
R1310 T4271 T4234 xcomp see,developed
R1311 T4272 T4271 dobj Methods,see
R1312 T4273 T4234 punct ),developed
R1313 T4274 T4234 cc and,developed
R1314 T4275 T4234 conj served,developed
R1315 T4276 T4275 prep as,served
R1316 T4277 T4278 det the,basis
R1317 T4278 T4276 pobj basis,as
R1318 T4279 T4278 prep for,basis
R1319 T4280 T4281 compound strain,comparisons
R132 T718 T719 det a,total
R1320 T4281 T4279 pobj comparisons,for
R1321 T4282 T4234 punct .,developed
R1322 T4284 T4285 prep After,characterized
R1323 T4286 T4284 pcomp stabilizing,After
R1324 T4287 T4288 det each,congenic
R1325 T4288 T4286 dobj congenic,stabilizing
R1326 T4289 T4285 punct ", ",characterized
R1327 T4290 T4291 quantmod 12,14
R1328 T4291 T4285 nsubjpass 14,characterized
R1329 T4292 T4291 quantmod of,14
R133 T719 T717 pobj total,for
R1330 T4293 T4285 auxpass were,characterized
R1331 T4294 T4285 advmod phenotypically,characterized
R1332 T4295 T4285 prep for,characterized
R1333 T4296 T4295 pobj growth,for
R1334 T4297 T4296 cc and,growth
R1335 T4298 T4296 conj adiposity,growth
R1336 T4299 T4285 punct .,characterized
R1337 T4301 T4302 det The,strains
R1338 T4302 T4306 nsubjpass strains,characterized
R1339 T4303 T4302 nmod HG2D,strains
R134 T720 T719 prep of,total
R1340 T4304 T4303 cc and,HG2D
R1341 T4305 T4303 conj HG5,HG2D
R1342 T4307 T4306 auxpass were,characterized
R1343 T4308 T4306 neg not,characterized
R1344 T4309 T4306 prep due,characterized
R1345 T4310 T4309 pcomp to,due
R1346 T4311 T4312 amod reproductive,problems
R1347 T4312 T4309 pobj problems,due
R1348 T4313 T4306 punct .,characterized
R1349 T4315 T4316 det The,points
R135 T721 T722 nummod eight,strains
R1350 T4316 T4319 nsubjpass points,refined
R1351 T4317 T4316 amod recombinant,points
R1352 T4318 T4316 compound end,points
R1353 T4320 T4316 prep for,points
R1354 T4321 T4322 det all,strains
R1355 T4322 T4320 pobj strains,for
R1356 T4323 T4319 auxpass were,refined
R1357 T4324 T4319 advcl using,refined
R1358 T4325 T4326 compound microsatellite,markers
R1359 T4326 T4324 dobj markers,using
R136 T722 T720 pobj strains,of
R1360 T4327 T4326 acl flanking,markers
R1361 T4328 T4329 det each,region
R1362 T4329 T4327 dobj region,flanking
R1363 T4330 T4329 compound donor,region
R1364 T4331 T4332 punct (,File
R1365 T4332 T4319 parataxis File,refined
R1366 T4333 T4332 amod Additional,File
R1367 T4334 T4332 nummod 2,File
R1368 T4335 T4332 punct ),File
R1369 T4336 T4319 punct .,refined
R137 T723 T697 punct .,developed
R1378 T6950 T6951 nmod MMU2,strain
R1379 T6951 T6954 compound strain,characterization
R138 T725 T726 amod Phenotypic,characterization
R1380 T6952 T6953 npadvmod speed,congenic
R1381 T6953 T6951 amod congenic,strain
R1382 T6956 T6957 prep Due,queried
R1383 T6958 T6956 pcomp to,Due
R1384 T6959 T6960 det the,nature
R1385 T6960 T6956 pobj nature,Due
R1386 T6961 T6960 amod overlapping,nature
R1387 T6962 T6960 prep of,nature
R1388 T6963 T6964 det the,congenics
R1389 T6964 T6962 pobj congenics,of
R139 T726 T727 nsubj characterization,confirmed
R1390 T6965 T6964 compound MMU2,congenics
R1391 T6966 T6957 punct ", ",queried
R1392 T6967 T6968 nummod five,regions
R1393 T6968 T6957 nsubjpass regions,queried
R1394 T6969 T6968 amod distinct,regions
R1395 T6970 T6968 amod chromosomal,regions
R1396 T6971 T6968 punct (,regions
R1397 T6972 T6973 nmod Regions,I
R1398 T6973 T6968 appos I,regions
R1399 T6974 T6975 punct –,V
R14 T593 T594 nmod growth,modifier
R140 T728 T726 prep of,characterization
R1400 T7033 T7013 punct .,describe
R1401 T6975 T6973 prep V,I
R1402 T7035 T7036 nmod B6.CAST,MMU2
R1403 T6976 T6957 punct ),queried
R1404 T7036 T7037 nmod MMU2,strains
R1405 T6977 T6957 auxpass were,queried
R1406 T7038 T7039 npadvmod speed,congenic
R1407 T7039 T7037 amod congenic,strains
R1408 T6978 T6957 prep for,queried
R1409 T7041 T7042 det The,strain
R141 T729 T730 det the,panel
R1410 T7042 T7044 nsubj strain,exhibited
R1411 T6979 T6980 det the,presence
R1412 T7043 T7042 compound B62D,strain
R1413 T7045 T7046 det the,decreases
R1414 T6980 T6978 pobj presence,for
R1415 T7046 T7044 dobj decreases,exhibited
R1416 T7047 T7046 amod largest,decreases
R1417 T6981 T6980 prep of,presence
R1418 T7048 T7049 punct (,0.0001
R1419 T7049 T7047 parataxis 0.0001,largest
R142 T730 T728 pobj panel,of
R1420 T7050 T7049 nsubj P,0.0001
R1421 T7051 T7049 punct <,0.0001
R1422 T7052 T7049 punct ),0.0001
R1423 T7053 T7046 prep in,decreases
R1424 T7054 T7055 compound body,weight
R1425 T7055 T7053 pobj weight,in
R1426 T7056 T7046 prep of,decreases
R1427 T7057 T7058 det any,B6.CAST
R1428 T7058 T7056 pobj B6.CAST,of
R1429 T6982 T6981 pobj QTL,of
R143 T731 T730 compound MMU2,panel
R1430 T7059 T7058 amod congenic,B6.CAST
R1431 T7060 T7061 punct (,File
R1432 T7061 T7044 parataxis File,exhibited
R1433 T7062 T7061 amod Additional,File
R1434 T6983 T6984 punct (,Figure
R1435 T7063 T7061 nummod 3,File
R1436 T7064 T7061 punct ),File
R1437 T6984 T6957 parataxis Figure,queried
R1438 T7065 T7044 punct .,exhibited
R1439 T7067 T7068 det Both,sexes
R144 T732 T733 det the,segregation
R1440 T6985 T6984 nummod 2,Figure
R1441 T6986 T6984 punct ),Figure
R1442 T7068 T7069 nsubj sexes,had
R1443 T7070 T7069 dobj reductions,had
R1444 T7071 T7070 prep in,reductions
R1445 T6987 T6957 punct .,queried
R1446 T7072 T7071 pobj weight,in
R1447 T7073 T7070 prep at,reductions
R1448 T7074 T7075 nummod 2,weeks
R1449 T6989 T6990 prep As,tested
R145 T733 T727 dobj segregation,confirmed
R1450 T7075 T7073 pobj weeks,at
R1451 T7076 T7074 punct (,2
R1452 T7077 T7074 appos 2WK,2
R1453 T7078 T7074 punct ),2
R1454 T6991 T6992 det a,analysis
R1455 T7079 T7074 punct ", ",2
R1456 T7080 T7074 conj 3,2
R1457 T7081 T7080 punct (,3
R1458 T6992 T6989 pobj analysis,As
R1459 T7082 T7080 appos 3WK,3
R146 T734 T733 prep of,segregation
R1460 T7083 T7080 punct ),3
R1461 T7084 T7080 punct ", ",3
R1462 T6993 T6992 amod separate,analysis
R1463 T7085 T7080 conj 6,3
R1464 T7086 T7085 punct (,6
R1465 T6994 T6990 nsubj we,tested
R1466 T7087 T7085 appos 6WK,6
R1467 T7088 T7085 punct ),6
R1468 T7089 T7085 cc and,6
R1469 T7090 T7085 conj 9,6
R147 T735 T736 amod multiple,growth
R1470 T6995 T6990 advmod also,tested
R1471 T7091 T7090 punct (,9
R1472 T7092 T7090 appos 9WK,9
R1473 T7093 T7075 punct ),weeks
R1474 T7094 T7075 prep of,weeks
R1475 T7095 T7094 pobj age,of
R1476 T7096 T7069 prep compared,had
R1477 T6996 T6990 prep for,tested
R1478 T7097 T7096 prep to,compared
R1479 T6997 T6996 pobj interactions,for
R148 T736 T737 nmod growth,QTL
R1480 T6998 T6997 prep between,interactions
R1481 T7098 T7099 compound control,mice
R1482 T7099 T7097 pobj mice,to
R1483 T6999 T7000 det each,region
R1484 T7100 T7099 compound B6C,mice
R1485 T7101 T7102 punct (,Figure
R1486 T7000 T6998 pobj region,between
R1487 T7102 T7069 parataxis Figure,had
R1488 T7103 T7102 nummod 3,Figure
R1489 T7104 T7102 punct ),Figure
R149 T737 T734 pobj QTL,of
R1490 T7001 T7000 compound donor,region
R1491 T7105 T7069 punct .,had
R1492 T7107 T7108 prep Despite,observed
R1493 T7002 T7000 cc and,region
R1494 T7109 T7110 amod large,decreases
R1495 T7003 T7004 det the,backgrounds
R1496 T7110 T7107 pobj decreases,Despite
R1497 T7004 T7000 conj backgrounds,region
R1498 T7111 T7110 prep in,decreases
R1499 T7112 T7113 compound body,weight
R15 T594 T598 nsubjpass modifier,identified
R150 T738 T736 cc and,growth
R1500 T7113 T7111 pobj weight,in
R1501 T7005 T7004 nummod two,backgrounds
R1502 T7114 T7108 punct ", ",observed
R1503 T7115 T7116 det no,differences
R1504 T7116 T7108 nsubjpass differences,observed
R1505 T7117 T7116 prep in,differences
R1506 T7006 T7004 amod distinct,backgrounds
R1507 T7118 T7119 compound growth,rates
R1508 T7119 T7117 pobj rates,in
R1509 T7120 T7121 punct (,gain
R151 T739 T736 conj obesity,growth
R1510 T7007 T7004 amod genetic,backgrounds
R1511 T7121 T7116 parataxis gain,differences
R1512 T7122 T7121 dep G26,gain
R1513 T7123 T7121 punct ", ",gain
R1514 T7008 T6990 punct .,tested
R1515 T7124 T7121 compound weight,gain
R1516 T7125 T7121 prep from,gain
R1517 T7126 T7127 quantmod 2,6
R1518 T7010 T7011 det The,sections
R1519 T7127 T7129 nummod 6,weeks
R152 T740 T727 cc and,confirmed
R1520 T7128 T7127 quantmod to,6
R1521 T7129 T7125 pobj weeks,from
R1522 T7130 T7121 cc and,gain
R1523 T7011 T7013 nsubj sections,describe
R1524 T7131 T7132 dep G29,gain
R1525 T7132 T7121 conj gain,gain
R1526 T7133 T7132 punct ", ",gain
R1527 T7134 T7132 compound weight,gain
R1528 T7135 T7132 prep from,gain
R1529 T7136 T7137 quantmod 2,9
R153 T741 T742 advmod strongly,suggested
R1530 T7012 T7011 amod following,sections
R1531 T7137 T7139 nummod 9,weeks
R1532 T7014 T7015 det the,phenotypes
R1533 T7015 T7013 dobj phenotypes,describe
R1534 T7138 T7137 quantmod to,9
R1535 T7016 T7015 prep for,phenotypes
R1536 T7139 T7135 pobj weeks,from
R1537 T7140 T7132 punct ),gain
R1538 T7141 T7108 auxpass were,observed
R1539 T7017 T7018 det each,strain
R154 T742 T727 conj suggested,confirmed
R1540 T7142 T7143 punct (,File
R1541 T7143 T7108 parataxis File,observed
R1542 T7144 T7143 amod Additional,File
R1543 T7018 T7016 pobj strain,for
R1544 T7145 T7143 nummod 3,File
R1545 T7146 T7143 punct ),File
R1546 T7147 T7108 punct .,observed
R1547 T7019 T7018 nmod B6.CAST,strain
R1548 T7149 T7150 advmod Therefore,harbors
R1549 T7020 T7019 cc and,B6.CAST
R155 T743 T744 mark that,modify
R1550 T7021 T7019 conj HG.CAST,B6.CAST
R1551 T7151 T7150 punct ", ",harbors
R1552 T7152 T7153 det the,region
R1553 T7153 T7150 nsubj region,harbors
R1554 T7154 T7153 nmod B62D,region
R1555 T7022 T7023 npadvmod speed,congenic
R1556 T7155 T7153 amod unique,region
R1557 T7156 T7153 punct (,region
R1558 T7157 T7153 appos Region,region
R1559 T7023 T7018 amod congenic,strain
R156 T744 T742 ccomp modify,suggested
R1560 T7158 T7157 nummod V,Region
R1561 T7159 T7150 punct ),harbors
R1562 T7160 T7161 preconj either,QTL
R1563 T7024 T7025 advmod as,as
R1564 T7161 T7150 dobj QTL,harbors
R1565 T7162 T7161 det an,QTL
R1566 T7163 T7164 amod early,growth
R1567 T7025 T7015 cc as,phenotypes
R1568 T7164 T7161 compound growth,QTL
R1569 T7165 T7164 punct -,growth
R157 T745 T746 det a,subset
R1570 T7026 T7025 advmod well,as
R1571 T7166 T7161 cc or,QTL
R1572 T7167 T7168 amod maternal,effect
R1573 T7168 T7161 conj effect,QTL
R1574 T7027 T7028 det the,results
R1575 T7169 T7168 compound genotype,effect
R1576 T7170 T7171 dep which,produces
R1577 T7171 T7168 relcl produces,effect
R1578 T7172 T7173 det a,decrease
R1579 T7173 T7171 dobj decrease,produces
R158 T746 T744 nsubj subset,modify
R1580 T7174 T7173 amod distinct,decrease
R1581 T7028 T7015 conj results,phenotypes
R1582 T7175 T7173 prep in,decrease
R1583 T7176 T7177 compound body,weight
R1584 T7177 T7175 pobj weight,in
R1585 T7178 T7179 amod prior,to
R1586 T7029 T7028 prep of,results
R1587 T7179 T7171 prep to,produces
R1588 T7180 T7179 pobj 2WK,to
R1589 T7030 T7031 det the,analysis
R159 T747 T746 prep of,subset
R1590 T7181 T7150 punct .,harbors
R1591 T7031 T7029 pobj analysis,of
R1592 T7183 T7184 det These,effects
R1593 T7032 T7031 compound interaction,analysis
R1594 T7184 T7185 nsubj effects,are
R1595 T7243 T7244 nsubj 9WK,was
R1596 T7186 T7185 acomp evident,are
R1597 T7187 T7185 prep in,are
R1598 T7188 T7189 det the,curves
R1599 T7189 T7187 pobj curves,in
R16 T595 T593 punct (,growth
R160 T748 T749 det these,loci
R1600 T7190 T7189 compound growth,curves
R1601 T7244 T7241 ccomp was,were
R1602 T7191 T7189 prep for,curves
R1603 T7192 T7193 det both,sexes
R1604 T7245 T7244 acomp significant,was
R1605 T7193 T7191 pobj sexes,for
R1606 T7194 T7193 prep of,sexes
R1607 T7246 T7241 punct ", ",were
R1608 T7195 T7196 det each,strain
R1609 T7196 T7194 pobj strain,of
R161 T749 T747 pobj loci,of
R1610 T7247 T7248 amod female,6WK
R1611 T7197 T7198 punct (,Figure
R1612 T7198 T7185 parataxis Figure,are
R1613 T7199 T7198 nummod 3,Figure
R1614 T7248 T7241 nsubj 6WK,were
R1615 T7200 T7198 punct ),Figure
R1616 T7201 T7185 punct .,are
R1617 T7249 T7248 cc and,6WK
R1618 T7203 T7204 advmod Additionally,displayed
R1619 T7250 T7248 conj 9WK,6WK
R162 T750 T751 det the,effects
R1620 T7205 T7204 punct ", ",displayed
R1621 T7206 T7207 compound B62D,mice
R1622 T7207 T7204 nsubj mice,displayed
R1623 T7251 T7241 acomp suggestive,were
R1624 T7208 T7209 advmod significantly,shorter
R1625 T7209 T7210 amod shorter,lengths
R1626 T7210 T7204 dobj lengths,displayed
R1627 T7252 T7241 prep at,were
R1628 T7211 T7210 compound tail,lengths
R1629 T7212 T7204 prep despite,displayed
R163 T751 T744 dobj effects,modify
R1630 T7213 T7214 det no,difference
R1631 T7214 T7212 pobj difference,despite
R1632 T7215 T7214 prep in,difference
R1633 T7216 T7217 amod naso-anal,length
R1634 T7253 T7254 nsubj P,0.05
R1635 T7217 T7215 pobj length,in
R1636 T7218 T7217 punct (,length
R1637 T7219 T7217 appos NA,length
R1638 T7220 T7204 punct ),displayed
R1639 T7254 T7252 pcomp 0.05,at
R164 T752 T751 prep of,effects
R1640 T7221 T7222 punct (,Table
R1641 T7222 T7204 parataxis Table,displayed
R1642 T7223 T7222 nummod 2,Table
R1643 T7255 T7254 punct <,0.05
R1644 T7224 T7222 punct ),Table
R1645 T7225 T7204 punct .,displayed
R1646 T7256 T7241 punct ),were
R1647 T7227 T7228 prep In,displayed
R1648 T7257 T7234 cc and,decreases
R1649 T7229 T7227 pobj contrast,In
R165 T753 T754 det the,deletion
R1650 T7230 T7228 punct ", ",displayed
R1651 T7231 T7232 compound B62M,mice
R1652 T7232 T7228 nsubj mice,displayed
R1653 T7258 T7259 amod significant,decreases
R1654 T7233 T7234 amod small,decreases
R1655 T7234 T7228 dobj decreases,displayed
R1656 T7259 T7234 conj decreases,decreases
R1657 T7235 T7234 prep in,decreases
R1658 T7236 T7237 compound body,weights
R1659 T7260 T7259 prep in,decreases
R166 T754 T752 pobj deletion,of
R1660 T7237 T7235 pobj weights,in
R1661 T7238 T7237 cc and,weights
R1662 T7239 T7237 conj growth,weights
R1663 T7240 T7241 punct (,were
R1664 T7261 T7262 nmod NA,length
R1665 T7241 T7234 parataxis were,decreases
R1666 T7242 T7243 amod male,9WK
R1667 T7262 T7260 pobj length,in
R1668 T7263 T7264 punct (,0.0152
R1669 T7264 T7261 parataxis 0.0152,NA
R167 T755 T754 compound hg,deletion
R1670 T7349 T7350 compound tail,length
R1671 T7350 T7347 conj length,weight
R1672 T7351 T7350 punct ", ",length
R1673 T7265 T7266 amod male,P
R1674 T7352 T7350 cc but,length
R1675 T7353 T7352 neg not,but
R1676 T7354 T7350 conj NA,length
R1677 T7266 T7264 nsubj P,0.0152
R1678 T7355 T7333 punct .,disjoined
R1679 T7267 T7264 punct =,0.0152
R168 T756 T727 punct .,confirmed
R1680 T7357 T7358 det The,QTL
R1681 T7358 T7360 nsubj QTL,increases
R1682 T7359 T7358 amod third,QTL
R1683 T7268 T7264 punct ),0.0152
R1684 T7361 T7358 punct ", ",QTL
R1685 T7362 T7358 acl located,QTL
R1686 T7269 T7261 cc and,NA
R1687 T7363 T7362 prep within,located
R1688 T7364 T7365 det the,region
R1689 T7270 T7261 conj tail,NA
R169 T758 T759 det The,panel
R1690 T7365 T7363 pobj region,within
R1691 T7366 T7365 nmod B62D,region
R1692 T7367 T7365 amod unique,region
R1693 T7271 T7272 punct (,File
R1694 T7368 T7365 punct (,region
R1695 T7369 T7365 appos Region,region
R1696 T7272 T7228 parataxis File,displayed
R1697 T7370 T7369 nummod V,Region
R1698 T7371 T7360 punct ),increases
R1699 T7372 T7360 punct ", ",increases
R17 T596 T593 appos hg,growth
R170 T759 T761 nsubj panel,consisted
R1700 T7373 T7360 dobj NA,increases
R1701 T7273 T7272 amod Additional,File
R1702 T7374 T7360 advcl canceling,increases
R1703 T7375 T7376 det the,effects
R1704 T7274 T7272 nummod 3,File
R1705 T7376 T7374 dobj effects,canceling
R1706 T7377 T7376 prep of,effects
R1707 T7378 T7379 det the,QTL
R1708 T7275 T7272 cc and,File
R1709 T7379 T7381 nsubj QTL,decreasing
R171 T760 T759 amod second,panel
R1710 T7380 T7379 compound B62M,QTL
R1711 T7381 T7377 pcomp decreasing,of
R1712 T7276 T7272 conj Table,File
R1713 T7382 T7383 punct (,Region
R1714 T7383 T7379 parataxis Region,QTL
R1715 T7277 T7276 nummod 2,Table
R1716 T7384 T7383 nummod IV,Region
R1717 T7385 T7383 punct ),Region
R1718 T7278 T7272 punct ),File
R1719 T7386 T7381 dobj NA,decreasing
R172 T762 T761 prep of,consisted
R1720 T7279 T7228 punct .,displayed
R1721 T7387 T7360 punct .,increases
R1722 T7281 T7282 det The,decrease
R1723 T7389 T7390 compound B62PM,females
R1724 T7390 T7391 nsubj females,had
R1725 T7282 T7283 nsubj decrease,is
R1726 T7392 T7391 dobj decreases,had
R1727 T7393 T7392 prep in,decreases
R1728 T7394 T7395 det all,traits
R1729 T7284 T7282 prep in,decrease
R173 T763 T764 amod individual,regions
R1730 T7395 T7393 pobj traits,in
R1731 T7396 T7397 npadvmod growth,related
R1732 T7397 T7395 amod related,traits
R1733 T7398 T7397 punct -,related
R1734 T7399 T7395 prep except,traits
R1735 T7400 T7399 pobj 2WK,except
R1736 T7401 T7400 cc and,2WK
R1737 T7285 T7284 pobj NA,in
R1738 T7402 T7400 conj 3WK,2WK
R1739 T7403 T7391 punct ", ",had
R174 T764 T762 pobj regions,of
R1740 T7404 T7405 mark while,seen
R1741 T7405 T7391 advcl seen,had
R1742 T7286 T7282 prep in,decrease
R1743 T7406 T7407 det no,differences
R1744 T7407 T7405 nsubjpass differences,seen
R1745 T7408 T7405 auxpass were,seen
R1746 T7287 T7288 compound B62M,mice
R1747 T7409 T7405 prep in,seen
R1748 T7410 T7409 pobj males,in
R1749 T7288 T7286 pobj mice,in
R175 T765 T764 compound donor,regions
R1750 T7411 T7412 punct (,File
R1751 T7412 T7391 parataxis File,had
R1752 T7413 T7412 amod Additional,File
R1753 T7289 T7283 acomp surprising,is
R1754 T7414 T7412 nummod 3,File
R1755 T7415 T7412 punct ),File
R1756 T7416 T7391 punct .,had
R1757 T7290 T7291 mark since,nested
R1758 T7418 T7419 advmod Similarly,showed
R1759 T7291 T7283 advcl nested,is
R176 T766 T764 prep on,regions
R1760 T7420 T7419 punct ", ",showed
R1761 T7421 T7422 advmod only,females
R1762 T7292 T7293 det the,region
R1763 T7422 T7419 nsubj females,showed
R1764 T7423 T7422 compound B62P,females
R1765 T7424 T7422 cc and,females
R1766 T7293 T7291 nsubjpass region,nested
R1767 T7425 T7424 neg not,and
R1768 T7294 T7293 compound 2M,region
R1769 T7426 T7422 conj males,females
R177 T767 T768 det an,background
R1770 T7427 T7428 amod significant,decreases
R1771 T7428 T7419 dobj decreases,showed
R1772 T7429 T7428 prep in,decreases
R1773 T7430 T7429 pobj 9WK,in
R1774 T7295 T7293 compound donor,region
R1775 T7431 T7430 punct ", ",9WK
R1776 T7432 T7430 conj G26,9WK
R1777 T7296 T7291 auxpass is,nested
R1778 T7433 T7432 cc and,G26
R1779 T7434 T7432 conj G29,G26
R178 T768 T766 pobj background,on
R1780 T7435 T7436 punct (,File
R1781 T7297 T7291 advmod entirely,nested
R1782 T7436 T7419 parataxis File,showed
R1783 T7437 T7436 amod Additional,File
R1784 T7438 T7436 nummod 3,File
R1785 T7439 T7436 punct ),File
R1786 T7440 T7419 punct ", ",showed
R1787 T7441 T7419 advcl indicating,showed
R1788 T7298 T7291 prep within,nested
R1789 T7442 T7443 det these,strains
R179 T769 T768 compound HG,background
R1790 T7299 T7300 det the,region
R1791 T7443 T7445 nsubj strains,share
R1792 T7444 T7443 nummod two,strains
R1793 T7300 T7298 pobj region,within
R1794 T7445 T7441 advcl share,indicating
R1795 T7446 T7447 det a,QTL
R1796 T7301 T7300 compound 2D,region
R1797 T7447 T7445 dobj QTL,share
R1798 T7448 T7449 amod female,specific
R1799 T7449 T7447 amod specific,QTL
R18 T597 T594 punct ),modifier
R180 T770 T764 prep for,regions
R1800 T7302 T7300 compound donor,region
R1801 T7450 T7447 compound growth,QTL
R1802 T7451 T7452 punct (,Region
R1803 T7303 T7291 cc and,nested
R1804 T7452 T7445 parataxis Region,share
R1805 T7453 T7452 nummod II,Region
R1806 T7454 T7452 punct ),Region
R1807 T7304 T7305 compound B62D,mice
R1808 T7305 T7306 nsubj mice,showed
R1809 T7306 T7291 conj showed,nested
R181 T771 T772 det each,QTL
R1810 T7455 T7419 punct .,showed
R1811 T7307 T7308 det no,difference
R1812 T7457 T7458 prep In,linked
R1813 T7308 T7306 dobj difference,showed
R1814 T7459 T7460 det the,scan
R1815 T7460 T7457 pobj scan,In
R1816 T7309 T7308 prep in,difference
R1817 T7461 T7460 amod original,scan
R1818 T7462 T7460 compound genome,scan
R1819 T7463 T7464 compound body,fat
R182 T772 T770 pobj QTL,for
R1820 T7310 T7309 pobj NA,in
R1821 T7464 T7465 compound fat,percentage
R1822 T7465 T7458 nsubjpass percentage,linked
R1823 T7311 T7312 punct (,Figure
R1824 T7466 T7467 mark as,determined
R1825 T7467 T7465 advcl determined,percentage
R1826 T7312 T7306 parataxis Figure,showed
R1827 T7468 T7467 prep by,determined
R1828 T7469 T7470 amod chemical,analysis
R1829 T7470 T7468 pobj analysis,by
R183 T773 T764 prep on,regions
R1830 T7313 T7312 nummod 2,Figure
R1831 T7471 T7470 amod compositional,analysis
R1832 T7472 T7458 auxpass was,linked
R1833 T7473 T7458 neg not,linked
R1834 T7474 T7458 prep to,linked
R1835 T7475 T7474 pobj markers,to
R1836 T7476 T7475 prep on,markers
R1837 T7477 T7476 pobj MMU2,on
R1838 T7314 T7312 punct ),Figure
R1839 T7478 T7479 punct [,24
R184 T774 T775 nmod MMU,1
R1840 T7479 T7458 parataxis 24,linked
R1841 T7480 T7479 punct ],24
R1842 T7481 T7458 punct .,linked
R1843 T7315 T7283 punct .,is
R1844 T7483 T7484 advmod However,chose
R1845 T7317 T7318 det These,data
R1846 T7485 T7484 punct ", ",chose
R1847 T7486 T7487 mark since,found
R1848 T7487 T7484 advcl found,chose
R1849 T7318 T7319 nsubj data,indicate
R185 T775 T773 pobj 1,on
R1850 T7488 T7489 amod numerous,QTL
R1851 T7489 T7487 nsubjpass QTL,found
R1852 T7490 T7489 compound obesity,QTL
R1853 T7320 T7321 det the,presence
R1854 T7491 T7487 aux have,found
R1855 T7492 T7487 auxpass been,found
R1856 T7493 T7487 prep on,found
R1857 T7494 T7493 pobj MMU2,on
R1858 T7495 T7496 punct [,2
R1859 T7321 T7319 dobj presence,indicate
R186 T776 T775 punct ", ",1
R1860 T7496 T7487 parataxis 2,found
R1861 T7497 T7496 punct ],2
R1862 T7498 T7487 punct ", ",found
R1863 T7322 T7321 prep of,presence
R1864 T7499 T7500 dep some,discovered
R1865 T7500 T7487 advcl discovered,found
R1866 T7323 T7324 nummod three,QTL
R1867 T7501 T7499 prep of,some
R1868 T7502 T7501 pobj which,of
R1869 T7503 T7500 auxpass were,discovered
R187 T777 T775 conj 5,1
R1870 T7324 T7322 pobj QTL,of
R1871 T7504 T7500 prep in,discovered
R1872 T7505 T7504 pobj B6,in
R1873 T7506 T7500 prep by,discovered
R1874 T7325 T7324 prep with,QTL
R1875 T7507 T7508 compound CAST,crosses
R1876 T7508 T7506 pobj crosses,by
R1877 T7326 T7327 det the,region
R1878 T7509 T7510 punct [,25
R1879 T7510 T7500 parataxis 25,discovered
R188 T778 T777 punct ", ",5
R1880 T7327 T7325 pobj region,with
R1881 T7511 T7510 nummod 9,25
R1882 T7512 T7510 punct ",",25
R1883 T7513 T7510 punct ],25
R1884 T7328 T7327 nmod 2D,region
R1885 T7514 T7484 punct ", ",chose
R1886 T7515 T7484 nsubj we,chose
R1887 T7516 T7517 aux to,measure
R1888 T7517 T7484 xcomp measure,chose
R1889 T7518 T7519 amod dissected,weights
R189 T779 T777 conj 8,5
R1890 T7519 T7517 dobj weights,measure
R1891 T7329 T7327 amod unique,region
R1892 T7520 T7521 compound fat,pad
R1893 T7521 T7519 compound pad,weights
R1894 T7522 T7517 prep as,measure
R1895 T7330 T7319 punct .,indicate
R1896 T7523 T7524 det a,measure
R1897 T7524 T7522 pobj measure,as
R1898 T7525 T7526 advmod more,sensitive
R1899 T7332 T7333 dep Two,disjoined
R19 T599 T594 cc and,modifier
R190 T780 T779 punct ", ",8
R1900 T7526 T7524 amod sensitive,measure
R1901 T7527 T7524 prep of,measure
R1902 T7334 T7332 prep of,Two
R1903 T7528 T7527 pobj adiposity,of
R1904 T7529 T7484 punct .,chose
R1905 T7335 T7334 pobj which,of
R1906 T7531 T7532 nsubj Table,lists
R1907 T7336 T7333 auxpass are,disjoined
R1908 T7533 T7531 nummod 2,Table
R1909 T7534 T7535 det the,weights
R191 T781 T779 conj 9,8
R1910 T7337 T7333 agent by,disjoined
R1911 T7535 T7532 dobj weights,lists
R1912 T7536 T7535 prep of,weights
R1913 T7537 T7538 amod gonadal,pads
R1914 T7338 T7339 det the,strains
R1915 T7538 T7536 pobj pads,of
R1916 T7339 T7337 pobj strains,by
R1917 T7539 T7540 punct (,GFP
R1918 T7540 T7537 parataxis GFP,gonadal
R1919 T7541 T7540 punct ),GFP
R192 T782 T781 punct ", ",9
R1920 T7340 T7339 nmod B62M,strains
R1921 T7542 T7537 punct ", ",gonadal
R1922 T7543 T7537 conj femoral,gonadal
R1923 T7544 T7545 punct (,FFP
R1924 T7341 T7340 cc and,B62M
R1925 T7545 T7543 parataxis FFP,femoral
R1926 T7546 T7545 punct ),FFP
R1927 T7547 T7543 punct ", ",femoral
R1928 T7548 T7543 conj mesenteric,femoral
R1929 T7342 T7340 conj B62D,B62M
R193 T783 T781 conj 11,9
R1930 T7549 T7550 punct (,MFP
R1931 T7343 T7333 cc and,disjoined
R1932 T7550 T7548 parataxis MFP,mesenteric
R1933 T7551 T7550 punct ),MFP
R1934 T7552 T7548 cc and,mesenteric
R1935 T7344 T7345 advmod additively,decrease
R1936 T7553 T7548 conj retroperitoneal,mesenteric
R1937 T7554 T7555 punct (,RFP
R1938 T7555 T7553 parataxis RFP,retroperitoneal
R1939 T7556 T7555 punct ),RFP
R194 T784 T783 cc and,11
R1940 T7557 T7538 compound fat,pads
R1941 T7558 T7532 punct ", ",lists
R1942 T7345 T7333 conj decrease,disjoined
R1943 T7559 T7532 prep along,lists
R1944 T7346 T7347 compound body,weight
R1945 T7347 T7345 dobj weight,decrease
R1946 T7348 T7347 cc and,weight
R1947 T7560 T7559 prep with,along
R1948 T7561 T7562 amod total,weight
R1949 T7562 T7560 pobj weight,with
R195 T785 T783 conj 17,11
R1950 T7666 T7665 auxpass is,located
R1951 T7563 T7564 compound fat,pad
R1952 T7564 T7562 compound pad,weight
R1953 T7565 T7562 punct (,weight
R1954 T7566 T7562 appos sum,weight
R1955 T7567 T7566 prep of,sum
R1956 T7667 T7665 prep in,located
R1957 T7568 T7569 det the,pads
R1958 T7569 T7567 pobj pads,of
R1959 T7668 T7669 det the,region
R196 T786 T761 punct .,consisted
R1960 T7570 T7569 nummod four,pads
R1961 T7571 T7569 compound fat,pads
R1962 T7572 T7562 punct ),weight
R1963 T7573 T7562 punct ", ",weight
R1964 T7669 T7667 pobj region,in
R1965 T7574 T7575 compound adiposity,index
R1966 T7575 T7562 conj index,weight
R1967 T7670 T7669 nmod B62D,region
R1968 T7576 T7577 punct (,WSAC
R1969 T7577 T7575 parataxis WSAC,index
R197 T788 T789 prep Of,characterized
R1970 T7578 T7579 nsubj AI,TF
R1971 T7579 T7577 ccomp TF,WSAC
R1972 T7671 T7669 amod unique,region
R1973 T7580 T7579 punct =,TF
R1974 T7581 T7582 punct /,weight
R1975 T7672 T7669 punct (,region
R1976 T7582 T7579 prep weight,TF
R1977 T7583 T7582 prep at,weight
R1978 T7584 T7583 pobj sacrifice,at
R1979 T7673 T7669 appos Region,region
R198 T790 T791 det the,strains
R1980 T7585 T7577 punct (,WSAC
R1981 T7586 T7577 punct ),WSAC
R1982 T7587 T7577 punct ),WSAC
R1983 T7674 T7673 nummod V,Region
R1984 T7588 T7575 cc and,index
R1985 T7589 T7590 compound body,index
R1986 T7590 T7575 conj index,index
R1987 T7675 T7660 punct ),indicates
R1988 T7591 T7590 compound mass,index
R1989 T7592 T7593 punct (,WSAC
R199 T791 T788 pobj strains,Of
R1990 T7676 T7660 punct .,indicates
R1991 T7593 T7590 parataxis WSAC,index
R1992 T7594 T7593 nsubj BMI,WSAC
R1993 T7595 T7593 punct =,WSAC
R1994 T7596 T7597 punct /,NA2
R1995 T7597 T7593 prep NA2,WSAC
R1996 T7598 T7599 punct *,100
R1997 T7678 T7679 advmod Only,differences
R1998 T7599 T7597 acl 100,NA2
R1999 T7600 T7593 punct ),WSAC
R2 T576 T574 punct -,wide
R20 T600 T601 npadvmod background,independent
R200 T792 T791 nummod six,strains
R2000 T7601 T7532 prep for,lists
R2001 T7602 T7603 det each,strain
R2002 T7603 T7601 pobj strain,for
R2003 T7679 T7681 nsubjpass differences,observed
R2004 T7604 T7605 npadvmod MMU2,congenic
R2005 T7605 T7603 amod congenic,strain
R2006 T7606 T7532 punct .,lists
R2007 T7680 T7679 amod minor,differences
R2008 T7608 T7609 advcl Similar,displayed
R2009 T7682 T7679 prep in,differences
R201 T793 T791 amod developed,strains
R2010 T7610 T7608 prep to,Similar
R2011 T7611 T7612 amod large,differences
R2012 T7612 T7610 pobj differences,to
R2013 T7683 T7684 amod various,weights
R2014 T7613 T7612 prep in,differences
R2015 T7684 T7682 pobj weights,in
R2016 T7614 T7615 compound body,weight
R2017 T7615 T7613 pobj weight,in
R2018 T7685 T7686 compound fat,pad
R2019 T7616 T7617 det the,strain
R202 T794 T789 punct ", ",characterized
R2020 T7617 T7609 nsubj strain,displayed
R2021 T7618 T7617 compound B62D,strain
R2022 T7619 T7620 advmod highly,significant
R2023 T7686 T7684 compound pad,weights
R2024 T7620 T7621 amod significant,decreases
R2025 T7621 T7609 dobj decreases,displayed
R2026 T7687 T7681 auxpass were,observed
R2027 T7622 T7621 prep in,decreases
R2028 T7623 T7622 pobj adiposity,in
R2029 T7624 T7609 punct .,displayed
R203 T795 T789 nsubjpass five,characterized
R2030 T7688 T7681 prep for,observed
R2031 T7626 T7627 nsubj B62D,was
R2032 T7689 T7690 det the,strains
R2033 T7628 T7629 det the,strain
R2034 T7629 T7627 attr strain,was
R2035 T7690 T7688 pobj strains,for
R2036 T7630 T7629 amod only,strain
R2037 T7631 T7632 advmod where,had
R2038 T7691 T7690 nmod B62P,strains
R2039 T7632 T7629 relcl had,strain
R204 T796 T789 auxpass were,characterized
R2040 T7633 T7634 det both,sexes
R2041 T7634 T7632 nsubj sexes,had
R2042 T7692 T7691 cc and,B62P
R2043 T7635 T7636 amod significant,decreases
R2044 T7636 T7632 dobj decreases,had
R2045 T7637 T7636 prep in,decreases
R2046 T7638 T7637 pobj TF,in
R2047 T7639 T7638 punct ", ",TF
R2048 T7640 T7638 conj AI,TF
R2049 T7641 T7640 cc and,AI
R205 T797 T789 advmod successfully,characterized
R2050 T7693 T7691 conj B62PM,B62P
R2051 T7642 T7640 conj BMI,AI
R2052 T7643 T7627 punct .,was
R2053 T7694 T7695 punct (,Table
R2054 T7645 T7646 advmod Interestingly,seen
R2055 T7647 T7646 punct ", ",seen
R2056 T7695 T7681 parataxis Table,observed
R2057 T7648 T7649 det no,difference
R2058 T7649 T7646 nsubjpass difference,seen
R2059 T7650 T7649 prep in,difference
R206 T798 T789 cc and,characterized
R2060 T7696 T7695 nummod 2,Table
R2061 T7651 T7650 pobj adiposity,in
R2062 T7652 T7646 auxpass was,seen
R2063 T7653 T7646 prep in,seen
R2064 T7697 T7695 punct ),Table
R2065 T7654 T7655 compound B62M,mice
R2066 T7655 T7653 pobj mice,in
R2067 T7656 T7646 punct .,seen
R2068 T7698 T7681 punct .,observed
R2069 T7658 T7659 det This,discordance
R207 T799 T789 conj displayed,characterized
R2070 T7659 T7660 nsubj discordance,indicates
R2071 T7700 T7701 nmod HG.CAST,MMU2
R2072 T7661 T7662 det the,QTL
R2073 T7662 T7665 nsubjpass QTL,located
R2074 T7663 T7664 npadvmod leanness,promoting
R2075 T7701 T7702 nmod MMU2,panel
R2076 T7664 T7662 amod promoting,QTL
R2077 T7665 T7660 advcl located,indicates
R2078 T7703 T7704 npadvmod speed,congenic
R2079 T7704 T7702 amod congenic,panel
R208 T800 T801 amod significant,differences
R2080 T7706 T7707 nmod HG2P,mice
R2081 T7772 T7769 conj gain,size
R2082 T7773 T7772 cc and,gain
R2083 T7774 T7772 conj NA,gain
R2084 T7707 T7710 nsubj mice,displayed
R2085 T7775 T7774 punct (,NA
R2086 T7776 T7777 advmod only,in
R2087 T7708 T7706 cc and,HG2P
R2088 T7777 T7774 prep in,NA
R2089 T7778 T7777 pobj females,in
R209 T801 T799 dobj differences,displayed
R2090 T7779 T7757 punct ),decrease
R2091 T7709 T7706 conj HG2PM,HG2P
R2092 T7711 T7707 prep of,mice
R2093 T7780 T7757 punct ", ",decrease
R2094 T7781 T7782 mark while,decreases
R2095 T7782 T7757 advcl decreases,decrease
R2096 T7783 T7784 det a,QTL
R2097 T7712 T7713 det both,sexes
R2098 T7784 T7782 nsubj QTL,decreases
R2099 T7785 T7784 prep in,QTL
R21 T601 T602 amod independent,loci
R210 T802 T801 prep in,differences
R2100 T7786 T7787 det the,region
R2101 T7713 T7711 pobj sexes,of
R2102 T7787 T7785 pobj region,in
R2103 T7788 T7787 compound HG2M,region
R2104 T7789 T7782 advmod significantly,decreases
R2105 T7714 T7715 amod significant,decreases
R2106 T7790 T7791 compound tail,length
R2107 T7715 T7710 dobj decreases,displayed
R2108 T7791 T7782 dobj length,decreases
R2109 T7716 T7715 prep in,decreases
R211 T803 T802 pobj growth,in
R2110 T7792 T7755 punct .,indicate
R2111 T7717 T7718 amod post-weaning,weights
R2112 T7794 T7795 advcl Similar,seen
R2113 T7718 T7716 pobj weights,in
R2114 T7796 T7794 prep to,Similar
R2115 T7797 T7798 compound growth,traits
R2116 T7798 T7796 pobj traits,to
R2117 T7719 T7718 compound body,weights
R2118 T7799 T7800 det a,decrease
R2119 T7800 T7795 nsubjpass decrease,seen
R212 T804 T803 cc and,growth
R2120 T7801 T7800 amod general,decrease
R2121 T7720 T7718 cc and,weights
R2122 T7802 T7800 prep in,decrease
R2123 T7803 T7802 pobj GFP,in
R2124 T7721 T7722 compound growth,rates
R2125 T7804 T7803 punct ", ",GFP
R2126 T7805 T7803 conj MFP,GFP
R2127 T7806 T7805 punct ", ",MFP
R2128 T7722 T7718 conj rates,weights
R2129 T7807 T7805 conj RFP,MFP
R213 T805 T804 punct /,and
R2130 T7808 T7807 punct ", ",RFP
R2131 T7723 T7724 punct (,Table
R2132 T7809 T7807 conj TF,RFP
R2133 T7810 T7809 cc and,TF
R2134 T7811 T7809 conj AI,TF
R2135 T7812 T7795 auxpass were,seen
R2136 T7724 T7710 parataxis Table,displayed
R2137 T7813 T7795 prep in,seen
R2138 T7814 T7815 nmod HG2P,mice
R2139 T7725 T7724 amod Additional,Table
R214 T806 T804 cc or,and
R2140 T7815 T7813 pobj mice,in
R2141 T7816 T7814 cc and,HG2P
R2142 T7817 T7814 conj HG2PM,HG2P
R2143 T7726 T7724 nummod 3,Table
R2144 T7818 T7819 punct (,Region
R2145 T7819 T7795 parataxis Region,seen
R2146 T7820 T7819 nummod II,Region
R2147 T7821 T7819 punct ),Region
R2148 T7822 T7823 punct (,Table
R2149 T7727 T7724 punct ),Table
R215 T807 T803 conj obesity,growth
R2150 T7823 T7795 parataxis Table,seen
R2151 T7824 T7823 nummod 2,Table
R2152 T7825 T7823 punct ),Table
R2153 T7728 T7710 punct .,displayed
R2154 T7826 T7795 punct .,seen
R2155 T7828 T7829 det These,differences
R2156 T7730 T7731 prep In,displayed
R2157 T7829 T7830 nsubj differences,are
R2158 T7831 T7829 prep in,differences
R2159 T7832 T7831 pobj adiposity,in
R216 T808 T809 mark as,compared
R2160 T7732 T7730 pobj addition,In
R2161 T7833 T7830 advmod likely,are
R2162 T7834 T7835 amod pleiotropic,effects
R2163 T7835 T7830 attr effects,are
R2164 T7836 T7835 prep of,effects
R2165 T7733 T7731 punct ", ",displayed
R2166 T7837 T7838 det the,QTL
R2167 T7838 T7836 pobj QTL,of
R2168 T7734 T7735 det the,strain
R2169 T7839 T7838 compound growth,QTL
R217 T809 T799 advcl compared,displayed
R2170 T7840 T7838 acl shared,QTL
R2171 T7841 T7840 prep between,shared
R2172 T7842 T7843 det these,strains
R2173 T7735 T7731 nsubj strain,displayed
R2174 T7843 T7841 pobj strains,between
R2175 T7844 T7843 nummod two,strains
R2176 T7736 T7735 compound HG2M,strain
R2177 T7845 T7830 punct .,are
R2178 T7847 T7848 advmod Surprisingly,displayed
R2179 T7737 T7738 advmod highly,significant
R218 T810 T809 prep to,compared
R2180 T7849 T7848 punct ", ",displayed
R2181 T7850 T7851 compound HG2M,mice
R2182 T7738 T7739 amod significant,decreases
R2183 T7851 T7848 nsubj mice,displayed
R2184 T7852 T7853 amod striking,differences
R2185 T7739 T7731 dobj decreases,displayed
R2186 T7853 T7848 dobj differences,displayed
R2187 T7854 T7853 compound sex,differences
R2188 T7855 T7853 prep in,differences
R2189 T7856 T7855 pobj adiposity,in
R219 T811 T810 pobj controls,to
R2190 T7740 T7739 prep in,decreases
R2191 T7857 T7848 punct .,displayed
R2192 T7741 T7740 pobj length,in
R2193 T7859 T7860 nsubj Males,exhibited
R2194 T7861 T7862 det an,increase
R2195 T7742 T7731 punct ", ",displayed
R2196 T7862 T7860 dobj increase,exhibited
R2197 T7863 T7862 prep in,increase
R2198 T7864 T7863 pobj AI,in
R2199 T7865 T7866 punct (,0.0256
R22 T602 T594 conj loci,modifier
R220 T812 T789 punct .,characterized
R2200 T7866 T7862 parataxis 0.0256,increase
R2201 T7867 T7866 nsubj P,0.0256
R2202 T7743 T7731 advcl similar,displayed
R2203 T7868 T7866 punct =,0.0256
R2204 T7869 T7866 punct ),0.0256
R2205 T7744 T7743 prep to,similar
R2206 T7870 T7862 prep with,increase
R2207 T7871 T7872 det a,decrease
R2208 T7872 T7870 pobj decrease,with
R2209 T7745 T7746 compound B62M,mice
R221 T814 T815 det All,five
R2210 T7873 T7872 prep in,decrease
R2211 T7874 T7873 pobj BMI,in
R2212 T7875 T7876 punct (,0.0462
R2213 T7746 T7744 pobj mice,to
R2214 T7876 T7872 parataxis 0.0462,decrease
R2215 T7877 T7876 nsubj P,0.0462
R2216 T7747 T7748 punct (,Table
R2217 T7748 T7731 parataxis Table,displayed
R2218 T7749 T7748 nummod 2,Table
R2219 T7750 T7748 punct ),Table
R222 T815 T816 nsubj five,displayed
R2220 T7751 T7731 punct .,displayed
R2221 T7878 T7876 punct =,0.0462
R2222 T7879 T7876 punct ),0.0462
R2223 T7753 T7754 det These,results
R2224 T7880 T7860 cc and,exhibited
R2225 T7754 T7755 nsubj results,indicate
R2226 T7881 T7882 det the,opposite
R2227 T7882 T7884 nsubjpass opposite,seen
R2228 T7756 T7757 nsubj QTL,decrease
R2229 T7883 T7882 amod exact,opposite
R223 T816 T817 ccomp displayed,unmasked
R2230 T7884 T7860 conj seen,exhibited
R2231 T7885 T7884 auxpass was,seen
R2232 T7886 T7884 prep in,seen
R2233 T7757 T7755 advcl decrease,indicate
R2234 T7887 T7886 pobj females,in
R2235 T7888 T7889 punct (,0.0425
R2236 T7758 T7756 prep within,QTL
R2237 T7889 T7884 parataxis 0.0425,seen
R2238 T7890 T7891 dep AI,0.0001
R2239 T7891 T7889 dep 0.0001,0.0425
R224 T818 T816 dobj phenotypes,displayed
R2240 T7759 T7758 pobj Region,within
R2241 T7892 T7891 punct ", ",0.0001
R2242 T7893 T7891 nsubj P,0.0001
R2243 T7894 T7891 punct <,0.0001
R2244 T7895 T7889 punct ;,0.0425
R2245 T7760 T7759 nummod II,Region
R2246 T7896 T7889 dep BMI,0.0425
R2247 T7897 T7889 punct ", ",0.0425
R2248 T7761 T7756 acl shared,QTL
R2249 T7898 T7889 nsubj P,0.0425
R225 T819 T818 amod similar,phenotypes
R2250 T7899 T7889 punct =,0.0425
R2251 T7900 T7889 punct ),0.0425
R2252 T7901 T7902 punct (,Table
R2253 T7902 T7884 parataxis Table,seen
R2254 T7903 T7902 nummod 2,Table
R2255 T7762 T7761 prep between,shared
R2256 T7904 T7902 punct ),Table
R2257 T7905 T7884 punct .,seen
R2258 T7763 T7764 det the,strains
R2259 T7907 T7908 advmod Therefore,impacted
R226 T820 T819 prep to,similar
R2260 T7764 T7762 pobj strains,between
R2261 T7909 T7908 punct ", ",impacted
R2262 T7910 T7911 det the,QTL
R2263 T7911 T7908 nsubjpass QTL,impacted
R2264 T7765 T7764 nmod HG2P,strains
R2265 T7912 T7911 compound obesity,QTL
R2266 T7913 T7911 prep in,QTL
R2267 T7766 T7765 cc and,HG2P
R2268 T7914 T7915 det the,region
R2269 T7915 T7913 pobj region,in
R227 T821 T820 pobj those,to
R2270 T7916 T7915 nmod HG2M,region
R2271 T7767 T7765 conj HG2PM,HG2P
R2272 T7917 T7915 amod unique,region
R2273 T7918 T7915 punct (,region
R2274 T7919 T7915 appos Region,region
R2275 T7768 T7769 compound body,size
R2276 T7920 T7919 nummod IV,Region
R2277 T7921 T7908 punct ),impacted
R2278 T7922 T7908 auxpass is,impacted
R2279 T7769 T7757 dobj size,decrease
R228 T822 T823 advmod originally,attributed
R2280 T7923 T7908 advmod profoundly,impacted
R2281 T7924 T7908 agent by,impacted
R2282 T7925 T7926 det the,presence
R2283 T7770 T7769 punct ", ",size
R2284 T7926 T7924 pobj presence,by
R2285 T7927 T7926 prep of,presence
R2286 T7771 T7772 compound weight,gain
R2287 T7928 T7927 pobj hg,of
R2288 T7929 T7908 punct .,impacted
R2289 T7983 T7977 cc and,B6
R229 T823 T821 acl attributed,those
R2290 T7932 T7931 prep of,Confirmation
R2291 T7933 T7934 compound QTL,hg
R2292 T7934 T7936 compound hg,interactions
R2293 T7935 T7934 punct -,hg
R2294 T7984 T7977 conj HG,B6
R2295 T7936 T7932 pobj interactions,of
R2296 T7985 T7986 punct (,hg
R2297 T7938 T7939 det An,feature
R2298 T7939 T7941 nsubj feature,was
R2299 T7940 T7939 amod important,feature
R23 T603 T604 amod quantitative,trait
R230 T824 T823 prep to,attributed
R2300 T7986 T7984 parataxis hg,HG
R2301 T7942 T7939 prep of,feature
R2302 T7943 T7944 poss our,design
R2303 T7944 T7942 pobj design,of
R2304 T7945 T7944 amod experimental,design
R2305 T7946 T7947 det the,ability
R2306 T7987 T7986 compound hg,hg
R2307 T7947 T7941 attr ability,was
R2308 T7948 T7949 aux to,test
R2309 T7949 T7947 acl test,ability
R231 T825 T826 det each,QTL
R2310 T7988 T7986 punct /,hg
R2311 T7950 T7949 prep for,test
R2312 T7951 T7950 pobj interactions,for
R2313 T7952 T7951 prep between,interactions
R2314 T7989 T7986 punct ),hg
R2315 T7953 T7952 pobj QTL,between
R2316 T7954 T7949 prep in,test
R2317 T7990 T7941 punct .,was
R2318 T7955 T7956 det each,region
R2319 T7956 T7954 pobj region,in
R232 T826 T824 pobj QTL,to
R2320 T7957 T7958 compound MMU2,donor
R2321 T7958 T7956 compound donor,region
R2322 T7992 T7993 amod Significant,interactions
R2323 T7959 T7949 cc and,test
R2324 T7960 T7949 conj genotype,test
R2325 T7961 T7960 prep at,genotype
R2326 T7962 T7963 det the,locus
R2327 T7993 T7994 nsubjpass interactions,viewed
R2328 T7963 T7961 pobj locus,at
R2329 T7964 T7963 compound HG,locus
R233 T827 T817 punct ", ",unmasked
R2330 T7965 T7960 punct ", ",genotype
R2331 T7995 T7993 prep between,interactions
R2332 T7966 T7967 mark since,introgressed
R2333 T7996 T7997 compound donor,region
R2334 T7967 T7960 advcl introgressed,genotype
R2335 T7968 T7969 amod identical,regions
R2336 T7997 T7995 pobj region,between
R2337 T7969 T7967 nsubjpass regions,introgressed
R2338 T7970 T7969 compound donor,regions
R2339 T7971 T7967 auxpass were,introgressed
R234 T828 T817 advmod however,unmasked
R2340 T7998 T7997 cc and,region
R2341 T7972 T7967 prep on,introgressed
R2342 T7973 T7974 nummod two,backgrounds
R2343 T7974 T7972 pobj backgrounds,on
R2344 T7999 T8000 compound HG,genotype
R2345 T7975 T7974 amod genetic,backgrounds
R2346 T7976 T7974 punct ", ",backgrounds
R2347 T8000 T7997 conj genotype,region
R2348 T7977 T7974 appos B6,backgrounds
R2349 T7978 T7979 punct (,+
R235 T829 T817 punct ", ",unmasked
R2350 T8001 T7994 auxpass were,viewed
R2351 T7979 T7977 punct +,B6
R2352 T7980 T7979 punct +,+
R2353 T8002 T7994 prep as,viewed
R2354 T7981 T7979 punct /,+
R2355 T7982 T7979 punct ),+
R2356 T8003 T8004 amod strong,evidence
R2357 T8004 T8002 pobj evidence,as
R2358 T8089 T8086 dobj set,represents
R2359 T8005 T8006 mark that,reside
R236 T830 T831 amod novel,phenotypes
R2360 T8090 T8089 prep of,set
R2361 T8091 T8092 amod linked,QTL
R2362 T8092 T8090 pobj QTL,of
R2363 T8006 T8004 acl reside,evidence
R2364 T8093 T8092 prep between,QTL
R2365 T8094 T8095 nummod 74.9,Mbp
R2366 T8095 T8093 pobj Mbp,between
R2367 T8096 T8094 cc and,74.9
R2368 T8007 T8008 compound hg,QTL
R2369 T8097 T8094 conj 181.8,74.9
R237 T831 T817 nsubjpass phenotypes,unmasked
R2370 T8098 T8089 prep within,set
R2371 T8008 T8006 nsubj QTL,reside
R2372 T8099 T8100 det the,regions
R2373 T8100 T8098 pobj regions,within
R2374 T8101 T8100 nmod 2M,regions
R2375 T8009 T8008 compound modifier,QTL
R2376 T8102 T8101 cc and,2M
R2377 T8103 T8101 conj 2D,2M
R2378 T8104 T8100 compound donor,regions
R2379 T8010 T8006 prep within,reside
R238 T832 T817 auxpass were,unmasked
R2380 T8105 T8100 punct (,regions
R2381 T8106 T8107 nmod Region,III
R2382 T8107 T8100 appos III,regions
R2383 T8011 T8012 det that,region
R2384 T8108 T8109 punct –,V
R2385 T8109 T8107 prep V,III
R2386 T8110 T8100 punct ),regions
R2387 T8012 T8010 pobj region,within
R2388 T8111 T8100 punct ", ",regions
R2389 T8112 T8113 dep some,interact
R239 T833 T817 prep in,unmasked
R2390 T8113 T8100 relcl interact,regions
R2391 T8013 T8012 amod unique,region
R2392 T8114 T8112 prep of,some
R2393 T8115 T8114 pobj which,of
R2394 T8116 T8113 prep with,interact
R2395 T8014 T8012 amod genomic,region
R2396 T8117 T8116 pobj hg,with
R2397 T8118 T8073 punct .,hypothesized
R2398 T8015 T7994 punct .,viewed
R2399 T8120 T8121 advcl Following,expected
R24 T604 T602 compound trait,loci
R240 T834 T833 pobj several,in
R2400 T8122 T8123 det this,logic
R2401 T8017 T8018 prep In,were
R2402 T8123 T8120 dobj logic,Following
R2403 T8124 T8121 nsubj we,expected
R2404 T8125 T8126 nsubj one,exhibit
R2405 T8126 T8121 advcl exhibit,expected
R2406 T8127 T8125 cc or,one
R2407 T8128 T8125 conj both,one
R2408 T8129 T8125 prep of,one
R2409 T8019 T8020 det the,analysis
R241 T835 T834 prep of,several
R2410 T8130 T8131 det these,strains
R2411 T8131 T8129 pobj strains,of
R2412 T8132 T8126 aux would,exhibit
R2413 T8133 T8134 nmod donor,region
R2414 T8134 T8135 nmod region,interactions
R2415 T8020 T8017 pobj analysis,In
R2416 T8135 T8126 dobj interactions,exhibit
R2417 T8136 T8134 prep by,region
R2418 T8137 T8138 compound HG,genotype
R2419 T8021 T8020 amod original,analysis
R242 T836 T837 det the,strains
R2420 T8138 T8136 pobj genotype,by
R2421 T8022 T8020 compound linkage,analysis
R2422 T8139 T8121 punct .,expected
R2423 T8023 T8024 det the,mode
R2424 T8141 T8142 advmod Unfortunately,were
R2425 T8024 T8018 nsubj mode,were
R2426 T8143 T8142 punct ", ",were
R2427 T8144 T8142 nsubj we,were
R2428 T8025 T8024 prep of,mode
R2429 T8145 T8142 acomp unable,were
R243 T837 T835 pobj strains,of
R2430 T8146 T8147 aux to,characterize
R2431 T8147 T8145 xcomp characterize,unable
R2432 T8026 T8027 compound gene,action
R2433 T8148 T8149 compound HG2D,mice
R2434 T8149 T8147 dobj mice,characterize
R2435 T8027 T8025 pobj action,of
R2436 T8150 T8142 punct .,were
R2437 T8152 T8153 advmod However,seen
R2438 T8028 T8024 cc and,mode
R2439 T8154 T8153 punct ", ",seen
R244 T838 T817 prep including,unmasked
R2440 T8155 T8156 mark as,noted
R2441 T8029 T8030 amod peak,location
R2442 T8156 T8153 advcl noted,seen
R2443 T8157 T8156 advmod above,noted
R2444 T8158 T8153 punct ", ",seen
R2445 T8030 T8024 conj location,mode
R2446 T8159 T8160 amod strong,effects
R2447 T8160 T8153 nsubjpass effects,seen
R2448 T8161 T8162 npadvmod sex,specific
R2449 T8031 T8030 prep of,location
R245 T839 T840 npadvmod sex,specific
R2450 T8162 T8160 amod specific,effects
R2451 T8163 T8162 punct -,specific
R2452 T8032 T8031 pobj Wg2,of
R2453 T8164 T8153 auxpass were,seen
R2454 T8165 T8153 prep in,seen
R2455 T8166 T8167 compound HG2M,mice
R2456 T8033 T8018 acomp dependent,were
R2457 T8167 T8165 pobj mice,in
R2458 T8168 T8153 punct .,seen
R2459 T8170 T8171 amod Significant,interactions
R246 T840 T842 amod specific,effects
R2460 T8171 T8183 nsubjpass interactions,identified
R2461 T8172 T8173 nmod 2M,region
R2462 T8034 T8033 prep on,dependent
R2463 T8173 T8171 nmod region,interactions
R2464 T8174 T8173 nmod donor,region
R2465 T8035 T8036 det the,presence
R2466 T8175 T8173 prep by,region
R2467 T8036 T8034 pobj presence,on
R2468 T8176 T8177 compound HG,genotype
R2469 T8177 T8175 pobj genotype,by
R247 T841 T840 punct -,specific
R2470 T8037 T8036 prep of,presence
R2471 T8178 T8173 prep by,region
R2472 T8179 T8178 pobj sex,by
R2473 T8180 T8181 nummod three,way
R2474 T8038 T8037 pobj hg,of
R2475 T8181 T8171 compound way,interactions
R2476 T8182 T8181 punct -,way
R2477 T8039 T8040 punct [,24
R2478 T8184 T8171 prep for,interactions
R2479 T8185 T8184 pobj AI,for
R248 T842 T838 pobj effects,including
R2480 T8040 T8018 parataxis 24,were
R2481 T8186 T8187 punct (,Figure
R2482 T8187 T8185 parataxis Figure,AI
R2483 T8188 T8189 nsubj P,0.0004
R2484 T8041 T8040 punct ],24
R2485 T8189 T8187 ccomp 0.0004,Figure
R2486 T8190 T8189 punct =,0.0004
R2487 T8191 T8187 punct ;,Figure
R2488 T8042 T8043 punct (,Table
R2489 T8192 T8187 nummod 4,Figure
R249 T843 T817 punct .,unmasked
R2490 T8193 T8187 punct ),Figure
R2491 T8194 T8185 cc and,AI
R2492 T8043 T8018 parataxis Table,were
R2493 T8044 T8043 nummod 1,Table
R2494 T8045 T8043 punct ),Table
R2495 T8195 T8185 conj TF,AI
R2496 T8046 T8018 punct .,were
R2497 T8196 T8183 auxpass were,identified
R2498 T8197 T8198 punct (,Table
R2499 T8048 T8049 prep In,tested
R25 T605 T602 punct (,loci
R250 T847 T848 det The,strains
R2500 T8198 T8183 parataxis Table,identified
R2501 T8199 T8198 nummod 3,Table
R2502 T8200 T8198 punct ),Table
R2503 T8201 T8183 punct .,identified
R2504 T8050 T8051 det the,study
R2505 T8203 T8204 det The,basis
R2506 T8204 T8205 nsubj basis,was
R2507 T8051 T8048 pobj study,In
R2508 T8206 T8204 prep of,basis
R2509 T8207 T8208 det these,interactions
R251 T848 T851 nsubj strains,constitute
R2510 T8208 T8206 pobj interactions,of
R2511 T8209 T8210 det a,decrease
R2512 T8052 T8051 amod present,study
R2513 T8210 T8205 attr decrease,was
R2514 T8211 T8210 prep in,decrease
R2515 T8212 T8213 compound HG2M,female
R2516 T8213 T8211 pobj female,in
R2517 T8053 T8049 punct ", ",tested
R2518 T8214 T8210 cc and,decrease
R2519 T8215 T8216 det an,increase
R252 T849 T850 npadvmod speed,congenic
R2520 T8216 T8217 nmod increase,adiposity
R2521 T8054 T8055 advmod only,mice
R2522 T8217 T8210 conj adiposity,decrease
R2523 T8218 T8216 prep in,increase
R2524 T8219 T8218 pobj HG2M,in
R2525 T8055 T8058 nsubjpass mice,characterized
R2526 T8220 T8219 amod male,HG2M
R2527 T8221 T8210 punct ", ",decrease
R2528 T8222 T8210 prep with,decrease
R2529 T8056 T8055 amod homozygous,mice
R253 T850 T848 amod congenic,strains
R2530 T8223 T8224 det no,differences
R2531 T8224 T8222 pobj differences,with
R2532 T8225 T8224 prep in,differences
R2533 T8057 T8055 amod congenic,mice
R2534 T8226 T8227 compound fat,accumulation
R2535 T8227 T8225 pobj accumulation,in
R2536 T8058 T8049 ccomp characterized,tested
R2537 T8228 T8224 prep across,differences
R2538 T8059 T8058 auxpass were,characterized
R2539 T8229 T8230 compound B62M,sexes
R254 T852 T848 acl developed,strains
R2540 T8230 T8228 pobj sexes,across
R2541 T8060 T8049 punct ", ",tested
R2542 T8231 T8205 punct .,was
R2543 T8233 T8234 amod Significant,interactions
R2544 T8061 T8049 advmod thus,tested
R2545 T8234 T8256 nsubjpass interactions,seen
R2546 T8235 T8236 nmod 2PM,region
R2547 T8236 T8238 nmod region,way
R2548 T8062 T8049 punct ", ",tested
R2549 T8237 T8236 nmod donor,region
R255 T853 T852 advmod herein,developed
R2550 T8238 T8234 nmod way,interactions
R2551 T8239 T8236 prep by,region
R2552 T8063 T8064 det the,effects
R2553 T8240 T8241 compound HG,genotype
R2554 T8241 T8239 pobj genotype,by
R2555 T8064 T8049 nsubjpass effects,tested
R2556 T8242 T8238 nummod two,way
R2557 T8243 T8238 punct -,way
R2558 T8244 T8238 cc and,way
R2559 T8065 T8064 amod overdominant,effects
R256 T854 T855 det an,resource
R2560 T8245 T8246 nmod 2PM,region
R2561 T8246 T8248 nmod region,way
R2562 T8247 T8246 nmod donor,region
R2563 T8248 T8238 conj way,way
R2564 T8249 T8246 prep by,region
R2565 T8250 T8251 compound HG,genotype
R2566 T8066 T8064 prep of,effects
R2567 T8251 T8249 pobj genotype,by
R2568 T8252 T8246 prep by,region
R2569 T8253 T8252 pobj sex,by
R257 T855 T851 dobj resource,constitute
R2570 T8067 T8066 pobj Wg2,of
R2571 T8254 T8248 nummod three,way
R2572 T8255 T8248 punct -,way
R2573 T8068 T8049 auxpass were,tested
R2574 T8257 T8256 auxpass were,seen
R2575 T8258 T8256 advmod also,seen
R2576 T8069 T8049 neg not,tested
R2577 T8259 T8256 prep for,seen
R2578 T8260 T8259 pobj TF,for
R2579 T8261 T8260 cc and,TF
R258 T856 T855 amod invaluable,resource
R2580 T8070 T8049 punct .,tested
R2581 T8262 T8260 conj AI,TF
R2582 T8263 T8264 punct (,Table
R2583 T8264 T8256 parataxis Table,seen
R2584 T8072 T8073 advmod However,hypothesized
R2585 T8265 T8264 nummod 3,Table
R2586 T8266 T8264 punct ),Table
R2587 T8267 T8256 punct .,seen
R2588 T8074 T8073 punct ", ",hypothesized
R2589 T8269 T8270 prep In,observed
R259 T857 T855 amod genomic,resource
R2590 T8271 T8269 pobj addition,In
R2591 T8272 T8270 punct ", ",observed
R2592 T8075 T8076 mark since,differed
R2593 T8273 T8274 amod significant,interactions
R2594 T8274 T8270 nsubjpass interactions,observed
R2595 T8076 T8073 advcl differed,hypothesized
R2596 T8275 T8276 nmod 2P,region
R2597 T8276 T8274 nmod region,interactions
R2598 T8277 T8276 nmod donor,region
R2599 T8077 T8078 poss its,location
R26 T606 T602 appos QTL,loci
R260 T858 T851 cc and,constitute
R2600 T8278 T8279 punct ×,genotype
R2601 T8279 T8276 prep genotype,region
R2602 T8280 T8279 compound HG,genotype
R2603 T8078 T8076 nsubj location,differed
R2604 T8281 T8270 auxpass were,observed
R2605 T8282 T8270 prep for,observed
R2606 T8283 T8284 det all,traits
R2607 T8079 T8078 amod original,location
R2608 T8284 T8282 pobj traits,for
R2609 T8285 T8284 acl listed,traits
R261 T859 T851 conj provide,constitute
R2610 T8286 T8270 punct ", ",observed
R2611 T8080 T8078 compound peak,location
R2612 T8287 T8288 mark although,reached
R2613 T8288 T8270 advcl reached,observed
R2614 T8289 T8290 det some,traits
R2615 T8290 T8288 nsubj traits,reached
R2616 T8291 T8288 aux did,reached
R2617 T8292 T8288 dobj significance,reached
R2618 T8081 T8076 advcl dependent,differed
R2619 T8293 T8288 prep at,reached
R262 T860 T861 det the,foundation
R2620 T8294 T8295 det the,0.0071
R2621 T8295 T8293 pobj 0.0071,at
R2622 T8082 T8081 prep on,dependent
R2623 T8296 T8295 amod critical,0.0071
R2624 T8297 T8295 nsubj P,0.0071
R2625 T8298 T8295 punct <,0.0071
R2626 T8083 T8082 pobj background,on
R2627 T8299 T8300 punct (,Table
R2628 T8300 T8270 parataxis Table,observed
R2629 T8084 T8073 nsubj we,hypothesized
R263 T861 T859 dobj foundation,provide
R2630 T8085 T8086 mark that,represents
R2631 T8086 T8073 ccomp represents,hypothesized
R2632 T8301 T8300 nummod 3,Table
R2633 T8302 T8300 punct ),Table
R2634 T8087 T8086 nsubj Wg2,represents
R2635 T8303 T8270 punct .,observed
R2636 T8088 T8089 det a,set
R2637 T8305 T8306 det The,basis
R2638 T8306 T8307 nsubj basis,was
R2639 T8308 T8306 prep for,basis
R264 T862 T863 aux to,identify
R2640 T8309 T8310 det each,interaction
R2641 T8310 T8308 pobj interaction,for
R2642 T8311 T8312 det a,decrease
R2643 T8312 T8307 attr decrease,was
R2644 T8313 T8312 prep in,decrease
R2645 T8314 T8313 pobj phenotype,in
R2646 T8315 T8312 prep in,decrease
R2647 T8316 T8315 pobj HG2P,in
R2648 T8317 T8312 prep compared,decrease
R2649 T8318 T8317 prep to,compared
R265 T863 T861 advcl identify,foundation
R2650 T8319 T8318 pobj HGC,to
R2651 T8320 T8312 cc and,decrease
R2652 T8321 T8322 det no,difference
R2653 T8322 T8312 conj difference,decrease
R2654 T8323 T8322 prep between,difference
R2655 T8324 T8323 pobj B62P,between
R2656 T8325 T8324 cc and,B62P
R2657 T8326 T8324 conj B6C,B62P
R2658 T8327 T8307 punct .,was
R2659 T8329 T8330 advmod Together,confirm
R266 T864 T865 det the,nature
R2660 T8331 T8332 det these,data
R2661 T8332 T8330 nsubj data,confirm
R2662 T8333 T8334 mark that,modify
R2663 T8334 T8330 ccomp modify,confirm
R2664 T8335 T8336 compound MMU2,QTL
R2665 T8336 T8334 nsubj QTL,modify
R2666 T8337 T8338 det the,effects
R2667 T8338 T8334 dobj effects,modify
R2668 T8339 T8338 prep of,effects
R2669 T8340 T8341 det the,deletion
R267 T865 T863 dobj nature,identify
R2670 T8341 T8339 pobj deletion,of
R2671 T8342 T8341 compound hg,deletion
R2672 T8343 T8330 punct .,confirm
R2673 T11091 T11092 npadvmod Speed,congenic
R2674 T11092 T11093 amod congenic,strains
R2675 T11094 T11093 prep for,strains
R2676 T11095 T11094 pobj QTL,for
R2677 T11096 T11093 prep on,strains
R2678 T11097 T11098 nmod MMU,1
R2679 T11098 T11096 pobj 1,on
R268 T866 T865 amod specific,nature
R2680 T11099 T11098 punct ", ",1
R2681 T11100 T11098 conj 8,1
R2682 T11101 T11100 punct ", ",8
R2683 T11102 T11100 conj 9,8
R2684 T11103 T11102 punct ", ",9
R2685 T11104 T11102 conj 11,9
R2686 T11105 T11104 cc and,11
R2687 T11106 T11104 conj 17,11
R2688 T11110 T11111 nsubj Q1Ucd1,was
R2689 T11112 T11110 acl affecting,Q1Ucd1
R269 T867 T865 prep of,nature
R2690 T11113 T11112 dobj G26,affecting
R2691 T11114 T11115 det the,significant
R2692 T11115 T11111 attr significant,was
R2693 T11116 T11115 amod least,significant
R2694 T11117 T11115 prep of,significant
R2695 T11118 T11119 det any,QTL
R2696 T11119 T11117 pobj QTL,of
R2697 T11120 T11119 acl identified,QTL
R2698 T11121 T11120 prep in,identified
R2699 T11122 T11123 det the,intercross
R27 T607 T594 punct ),modifier
R270 T868 T869 amod genetic,variation
R2700 T11123 T11121 pobj intercross,in
R2701 T11124 T11123 amod original,intercross
R2702 T11125 T11111 cc and,was
R2703 T11126 T11127 advmod only,reached
R2704 T11127 T11111 conj reached,was
R2705 T11128 T11129 det a,level
R2706 T11129 T11127 dobj level,reached
R2707 T11130 T11129 amod suggestive,level
R2708 T11131 T11129 prep of,level
R2709 T11132 T11131 pobj significance,of
R271 T869 T867 pobj variation,of
R2710 T11133 T11134 punct (,0.05
R2711 T11134 T11127 parataxis 0.05,reached
R2712 T11135 T11136 nsubj LOD,2.46
R2713 T11136 T11134 ccomp 2.46,0.05
R2714 T11137 T11136 punct =,2.46
R2715 T11138 T11134 punct ", ",0.05
R2716 T11139 T11134 nsubj P,0.05
R2717 T11140 T11134 punct <,0.05
R2718 T11141 T11134 punct ),0.05
R2719 T11142 T11143 punct [,26
R272 T870 T869 acl influencing,variation
R2720 T11143 T11127 parataxis 26,reached
R2721 T11144 T11143 punct ],26
R2722 T11145 T11111 punct .,was
R2723 T11147 T11148 prep In,had
R2724 T11149 T11147 pobj accordance,In
R2725 T11150 T11148 punct ", ",had
R2726 T11151 T11152 compound HG1,mice
R2727 T11152 T11148 nsubj mice,had
R2728 T11153 T11154 amod small,differences
R2729 T11154 T11148 dobj differences,had
R273 T871 T870 dobj growth,influencing
R2730 T11155 T11154 prep in,differences
R2731 T11156 T11157 det all,traits
R2732 T11157 T11155 pobj traits,in
R2733 T11158 T11157 nmod growth,traits
R2734 T11159 T11158 cc and,growth
R2735 T11160 T11158 conj length,growth
R2736 T11161 T11148 punct .,had
R2737 T11163 T11164 nsubj NA,was
R2738 T11165 T11163 prep in,NA
R2739 T11166 T11167 preconj both,sexes
R274 T872 T871 cc and,growth
R2740 T11167 T11165 pobj sexes,in
R2741 T11168 T11163 cc and,NA
R2742 T11169 T11170 nmod 2WK,6WK
R2743 T11170 T11163 conj 6WK,NA
R2744 T11171 T11170 punct ", ",6WK
R2745 T11172 T11170 nmod 3WK,6WK
R2746 T11173 T11170 punct ", ",6WK
R2747 T11174 T11170 cc and,6WK
R2748 T11175 T11176 compound tail,length
R2749 T11176 T11170 conj length,6WK
R275 T873 T871 conj obesity,growth
R2750 T11177 T11170 prep in,6WK
R2751 T11178 T11177 pobj females,in
R2752 T11179 T11164 acomp significant,was
R2753 T11180 T11164 prep at,was
R2754 T11181 T11182 det a,0.005
R2755 T11182 T11180 pobj 0.005,at
R2756 T11183 T11182 amod critical,0.005
R2757 T11184 T11182 nsubj P,0.005
R2758 T11185 T11182 punct <,0.005
R2759 T11186 T11187 punct (,Table
R276 T874 T851 punct .,constitute
R2760 T11187 T11164 parataxis Table,was
R2761 T11188 T11187 nummod 4,Table
R2762 T11189 T11187 punct ),Table
R2763 T11190 T11164 punct .,was
R2764 T11192 T11193 det The,difference
R2765 T11193 T11195 nsubj difference,was
R2766 T11194 T11193 amod only,difference
R2767 T11196 T11193 prep in,difference
R2768 T11197 T11196 pobj adiposity,in
R2769 T11198 T11199 det a,decrease
R277 T573 T574 npadvmod Genome,wide
R2770 T11199 T11195 attr decrease,was
R2771 T11200 T11199 amod significant,decrease
R2772 T11201 T11199 prep in,decrease
R2773 T11202 T11203 amod male,MFP
R2774 T11203 T11201 pobj MFP,in
R2775 T11204 T11205 punct (,Table
R2776 T11205 T11195 parataxis Table,was
R2777 T11206 T11205 nummod 5,Table
R2778 T11207 T11205 punct ),Table
R2779 T11208 T11195 punct .,was
R278 T2716 T2717 det The,use
R2780 T11210 T11211 det The,capture
R2781 T11211 T11213 nsubj capture,adds
R2782 T11212 T11211 amod successful,capture
R2783 T11214 T11211 cc and,capture
R2784 T11215 T11211 conj confirmation,capture
R2785 T11216 T11211 prep of,capture
R2786 T11217 T11218 det the,QTL
R2787 T11218 T11216 pobj QTL,of
R2788 T11219 T11220 amod small,effect
R2789 T11220 T11218 compound effect,QTL
R279 T2717 T2718 nsubj use,provided
R2790 T11221 T11222 compound Q1Ucd1,w26
R2791 T11222 T11218 compound w26,QTL
R2792 T11223 T11222 punct -,w26
R2793 T11224 T11213 dobj support,adds
R2794 T11225 T11213 prep to,adds
R2795 T11226 T11225 pcomp pursuing,to
R2796 T11227 T11226 dobj QTL,pursuing
R2797 T11228 T11227 acl identified,QTL
R2798 T11229 T11228 prep at,identified
R2799 T11230 T11231 amod suggestive,levels
R28 T608 T594 acl affecting,modifier
R280 T2719 T2717 prep of,use
R2800 T11231 T11229 pobj levels,at
R2801 T11232 T11231 prep of,levels
R2802 T11233 T11234 amod statistical,confidence
R2803 T11234 T11232 pobj confidence,of
R2804 T11235 T11228 prep from,identified
R2805 T11236 T11237 compound genome,scans
R2806 T11237 T11235 pobj scans,from
R2807 T11238 T11213 punct .,adds
R2808 T11242 T11243 nsubjpass Markers,linked
R2809 T11244 T11242 prep on,Markers
R281 T2720 T2721 compound mouse,models
R2810 T11245 T11244 pobj MMU8,on
R2811 T11246 T11243 auxpass were,linked
R2812 T11247 T11243 prep with,linked
R2813 T11248 T11247 pobj G29,with
R2814 T11249 T11243 prep in,linked
R2815 T11250 T11251 det the,intercross
R2816 T11251 T11249 pobj intercross,in
R2817 T11252 T11251 amod original,intercross
R2818 T11253 T11254 punct [,24
R2819 T11254 T11243 parataxis 24,linked
R282 T2721 T2719 pobj models,of
R2820 T11255 T11254 punct ],24
R2821 T11256 T11243 punct .,linked
R2822 T11258 T11259 det This,QTL
R2823 T11259 T11260 nsubj QTL,was
R2824 T11261 T11260 acomp small,was
R2825 T11262 T11260 punct ", ",was
R2826 T11263 T11264 advmod only,accounting
R2827 T11264 T11260 advcl accounting,was
R2828 T11265 T11264 prep for,accounting
R2829 T11266 T11267 nummod 4.3,%
R283 T2722 T2718 aux has,provided
R2830 T11267 T11265 pobj %,for
R2831 T11268 T11267 prep of,%
R2832 T11269 T11270 det the,variance
R2833 T11270 T11268 pobj variance,of
R2834 T11271 T11270 amod phenotypic,variance
R2835 T11272 T11260 punct .,was
R2836 T11274 T11275 advmod Interestingly,detected
R2837 T11275 T11285 ccomp detected,were
R2838 T11276 T11275 punct ", ",detected
R2839 T11277 T11275 prep in,detected
R284 T2723 T2724 amod valuable,insight
R2840 T11278 T11279 compound HG8,mice
R2841 T11279 T11277 pobj mice,in
R2842 T11280 T11281 det no,differences
R2843 T11281 T11275 nsubjpass differences,detected
R2844 T11282 T11281 prep in,differences
R2845 T11283 T11282 pobj growth,in
R2846 T11284 T11275 auxpass were,detected
R2847 T11286 T11285 punct ;,were
R2848 T11287 T11285 advmod however,were
R2849 T11288 T11285 punct ", ",were
R285 T2724 T2718 dobj insight,provided
R2850 T11289 T11285 nsubj they,were
R2851 T11290 T11291 advmod significantly,leaner
R2852 T11291 T11285 acomp leaner,were
R2853 T11292 T11291 prep than,leaner
R2854 T11293 T11292 pobj controls,than
R2855 T11294 T11295 punct (,Table
R2856 T11295 T11285 parataxis Table,were
R2857 T11296 T11295 nummod 5,Table
R2858 T11297 T11295 punct ),Table
R2859 T11298 T11285 punct .,were
R286 T2725 T2724 prep into,insight
R2860 T11300 T11301 prep In,was
R2861 T11302 T11300 pobj males,In
R2862 T11303 T11304 det a,decrease
R2863 T11304 T11306 nsubjpass decrease,detected
R2864 T11305 T11304 amod general,decrease
R2865 T11306 T11301 ccomp detected,was
R2866 T11307 T11304 prep in,decrease
R2867 T11308 T11309 compound fat,pad
R2868 T11309 T11310 compound pad,mass
R2869 T11310 T11307 pobj mass,in
R287 T2726 T2727 det the,etiology
R2870 T11311 T11310 punct ", ",mass
R2871 T11312 T11310 conj TF,mass
R2872 T11313 T11312 cc and,TF
R2873 T11314 T11312 conj AI,TF
R2874 T11315 T11306 auxpass was,detected
R2875 T11316 T11301 punct ;,was
R2876 T11317 T11301 advmod however,was
R2877 T11318 T11301 punct ", ",was
R2878 T11319 T11320 advmod only,MFP
R2879 T11320 T11301 nsubj MFP,was
R288 T2727 T2725 pobj etiology,into
R2880 T11321 T11301 acomp significant,was
R2881 T11322 T11301 prep at,was
R2882 T11323 T11324 det a,0.005
R2883 T11324 T11322 pobj 0.005,at
R2884 T11325 T11324 amod critical,0.005
R2885 T11326 T11324 nsubj P,0.005
R2886 T11327 T11324 punct <,0.005
R2887 T11328 T11301 punct .,was
R2888 T11330 T11331 amod Male,AI
R2889 T11331 T11332 nsubj AI,was
R289 T2728 T2727 prep of,etiology
R2890 T11333 T11334 advmod nearly,significant
R2891 T11334 T11332 acomp significant,was
R2892 T11335 T11332 prep at,was
R2893 T11336 T11337 det a,0.0082
R2894 T11337 T11335 pobj 0.0082,at
R2895 T11338 T11337 amod nominal,0.0082
R2896 T11339 T11337 nsubj P,0.0082
R2897 T11340 T11337 punct =,0.0082
R2898 T11341 T11332 punct .,was
R2899 T11343 T11344 amod Larger,decreases
R29 T609 T608 dobj growth,affecting
R290 T2729 T2730 amod monogenic,syndromes
R2900 T11344 T11345 nsubjpass decreases,seen
R2901 T11346 T11344 prep in,decreases
R2902 T11347 T11348 compound fat,mass
R2903 T11348 T11346 pobj mass,in
R2904 T11349 T11345 auxpass were,seen
R2905 T11350 T11345 prep in,seen
R2906 T11351 T11352 compound HG8,females
R2907 T11352 T11350 pobj females,in
R2908 T11353 T11345 punct ", ",seen
R2909 T11354 T11355 mark with,detected
R291 T2730 T2728 pobj syndromes,of
R2910 T11355 T11345 advcl detected,seen
R2911 T11356 T11357 amod significant,decreases
R2912 T11357 T11355 nsubj decreases,detected
R2913 T11358 T11355 prep for,detected
R2914 T11359 T11358 pobj GFP,for
R2915 T11360 T11359 punct ", ",GFP
R2916 T11361 T11359 conj MFP,GFP
R2917 T11362 T11361 cc and,MFP
R2918 T11363 T11361 conj AI,MFP
R2919 T11364 T11345 punct .,seen
R292 T2731 T2730 acl caused,syndromes
R2920 T11366 T11367 advmod Additionally,were
R2921 T11368 T11367 punct ", ",were
R2922 T11369 T11367 nsubj RFP,were
R2923 T11370 T11369 cc and,RFP
R2924 T11371 T11369 conj TF,RFP
R2925 T11372 T11373 advmod nearly,significant
R2926 T11373 T11367 acomp significant,were
R2927 T11374 T11367 prep with,were
R2928 T11375 T11376 amod nominal,values
R2929 T11376 T11374 pobj values,with
R293 T2732 T2731 agent by,caused
R2930 T11377 T11376 compound P,values
R2931 T11378 T11376 prep of,values
R2932 T11379 T11378 pobj 0.0208,of
R2933 T11380 T11379 cc and,0.0208
R2934 T11381 T11379 conj 0.0153,0.0208
R2935 T11382 T11367 punct ", ",were
R2936 T11383 T11367 advmod respectively,were
R2937 T11384 T11367 punct .,were
R2938 T11386 T11387 compound HG8,mice
R2939 T11387 T11388 nsubj mice,represent
R294 T2733 T2734 amod single,mutations
R2940 T11389 T11390 det a,model
R2941 T11390 T11388 dobj model,represent
R2942 T11391 T11390 amod lean,model
R2943 T11392 T11390 amod congenic,model
R2944 T11393 T11394 prep in,protect
R2945 T11394 T11390 relcl protect,model
R2946 T11395 T11393 pobj which,in
R2947 T11396 T11397 compound CAST,alleles
R2948 T11397 T11394 nsubj alleles,protect
R2949 T11398 T11394 prep against,protect
R295 T2734 T2732 pobj mutations,by
R2950 T11399 T11400 compound fat,accumulation
R2951 T11400 T11398 pobj accumulation,against
R2952 T11401 T11388 punct .,represent
R2953 T11405 T11406 compound CAST,alleles
R2954 T11406 T11407 nsubjpass alleles,found
R2955 T11408 T11406 prep in,alleles
R2956 T11409 T11410 det the,region
R2957 T11410 T11408 pobj region,in
R2958 T11411 T11410 amod proximal,region
R2959 T11412 T11410 prep of,region
R296 T2735 T2734 compound gene,mutations
R2960 T11413 T11412 pobj MMU9,of
R2961 T11414 T11407 auxpass were,found
R2962 T11415 T11407 advmod previously,found
R2963 T11416 T11417 aux to,linked
R2964 T11417 T11407 xcomp linked,found
R2965 T11418 T11417 auxpass be,linked
R2966 T11419 T11417 prep with,linked
R2967 T11420 T11421 det an,increase
R2968 T11421 T11419 pobj increase,with
R2969 T11422 T11421 prep in,increase
R297 T2736 T2718 punct .,provided
R2970 T11423 T11424 compound body,fat
R2971 T11424 T11425 compound fat,percentage
R2972 T11425 T11422 pobj percentage,in
R2973 T11426 T11421 cc and,increase
R2974 T11427 T11428 det a,decrease
R2975 T11428 T11421 conj decrease,increase
R2976 T11429 T11428 prep in,decrease
R2977 T11430 T11431 compound femur,length
R2978 T11431 T11429 pobj length,in
R2979 T11432 T11433 punct [,24
R298 T2738 T2739 advmod However,mimic
R2980 T11433 T11407 parataxis 24,found
R2981 T11434 T11433 punct ],24
R2982 T11435 T11407 punct .,found
R2983 T11437 T11438 det The,effects
R2984 T11438 T11439 nsubj effects,appeared
R2985 T11440 T11441 aux to,be
R2986 T11441 T11439 xcomp be,appeared
R2987 T11442 T11443 det the,result
R2988 T11443 T11441 attr result,be
R2989 T11444 T11443 prep of,result
R299 T2740 T2739 punct ", ",mimic
R2990 T11445 T11446 nummod two,QTL
R2991 T11446 T11444 pobj QTL,of
R2992 T11447 T11446 amod linked,QTL
R2993 T11448 T11446 punct ", ",QTL
R2994 T11449 T11446 appos Carfhg2,QTL
R2995 T11450 T11449 prep at,Carfhg2
R2996 T11451 T11452 nummod 10,cM
R2997 T11452 T11450 pobj cM,at
R2998 T11453 T11449 cc and,Carfhg2
R2999 T11454 T11449 conj Feml2,Carfhg2
R3 T578 T577 prep of,isolation
R30 T610 T609 punct ", ",growth
R300 T2741 T2742 amod such,models
R3000 T11455 T11454 prep at,Feml2
R3001 T11456 T11457 nummod 20,cM
R3002 T11457 T11455 pobj cM,at
R3003 T11535 T11533 punct ", ",increased
R3004 T11458 T11446 punct ", ",QTL
R3005 T11536 T11533 nsubjpass GFP,increased
R3006 T11537 T11536 punct ", ",GFP
R3007 T11459 T11446 prep instead,QTL
R3008 T11538 T11536 conj RFP,GFP
R3009 T11539 T11538 punct ", ",RFP
R301 T2742 T2739 nsubj models,mimic
R3010 T11460 T11459 pcomp of,instead
R3011 T11540 T11538 conj FFP,RFP
R3012 T11461 T11459 pobj one,instead
R3013 T11541 T11540 cc and,FFP
R3014 T11542 T11540 conj AI,FFP
R3015 T11462 T11463 advmod pleiotropically,impacting
R3016 T11543 T11533 auxpass were,increased
R3017 T11544 T11533 prep by,increased
R3018 T11545 T11546 nummod 29.0,%
R3019 T11463 T11461 acl impacting,one
R302 T2743 T2739 aux do,mimic
R3020 T11546 T11544 pobj %,by
R3021 T11547 T11546 punct ", ",%
R3022 T11464 T11465 det both,traits
R3023 T11548 T11549 nummod 51.2,%
R3024 T11549 T11546 conj %,%
R3025 T11465 T11463 dobj traits,impacting
R3026 T11550 T11549 punct ", ",%
R3027 T11551 T11552 nummod 42.9,%
R3028 T11552 T11549 conj %,%
R3029 T11466 T11467 punct (,Table
R303 T2744 T2739 neg not,mimic
R3030 T11553 T11552 cc and,%
R3031 T11554 T11555 nummod 30.0,%
R3032 T11467 T11439 parataxis Table,appeared
R3033 T11555 T11552 conj %,%
R3034 T11556 T11533 punct ", ",increased
R3035 T11557 T11533 advmod respectively,increased
R3036 T11558 T11533 punct .,increased
R3037 T11560 T11561 prep In,were
R3038 T11562 T11560 pobj females,In
R3039 T11563 T11564 det these,increases
R304 T2745 T2746 det the,complexity
R3040 T11468 T11467 nummod 1,Table
R3041 T11564 T11561 nsubj increases,were
R3042 T11565 T11566 advmod much,larger
R3043 T11566 T11561 acomp larger,were
R3044 T11469 T11467 punct ),Table
R3045 T11567 T11561 punct .,were
R3046 T11569 T11570 det The,measurements
R3047 T11570 T11572 nsubjpass measurements,increased
R3048 T11571 T11570 amod same,measurements
R3049 T11573 T11572 auxpass were,increased
R305 T2746 T2739 dobj complexity,mimic
R3050 T11470 T11439 punct .,appeared
R3051 T11574 T11572 prep by,increased
R3052 T11575 T11576 nummod 68.8,%
R3053 T11576 T11574 pobj %,by
R3054 T11577 T11576 punct ", ",%
R3055 T11578 T11579 nummod 99.4,%
R3056 T11472 T11473 prep In,was
R3057 T11579 T11576 conj %,%
R3058 T11580 T11579 punct ", ",%
R3059 T11581 T11582 nummod 69.7,%
R306 T2747 T2746 amod genetic,complexity
R3060 T11582 T11579 conj %,%
R3061 T11583 T11582 cc and,%
R3062 T11473 T11482 ccomp was,were
R3063 T11584 T11585 nummod 57.3,%
R3064 T11585 T11582 conj %,%
R3065 T11474 T11472 pobj support,In
R3066 T11586 T11572 punct ", ",increased
R3067 T11587 T11572 advcl relative,increased
R3068 T11588 T11587 prep to,relative
R3069 T11475 T11474 prep of,support
R307 T2748 T2746 prep of,complexity
R3070 T11589 T11590 compound HGC,females
R3071 T11590 T11588 pobj females,to
R3072 T11476 T11475 pobj this,of
R3073 T11591 T11572 punct .,increased
R3074 T11477 T11473 punct ", ",was
R3075 T11593 T11594 det A,reduction
R3076 T11594 T11600 nsubjpass reduction,detected
R3077 T11595 T11596 nummod 2.9,%
R3078 T11596 T11594 nmod %,reduction
R3079 T11597 T11596 cc and,%
R308 T2749 T2750 compound disease,traits
R3080 T11598 T11599 nummod 3.6,%
R3081 T11478 T11479 det the,increase
R3082 T11599 T11596 conj %,%
R3083 T11601 T11594 prep in,reduction
R3084 T11602 T11603 amod male,NA
R3085 T11479 T11473 nsubj increase,was
R3086 T11603 T11601 pobj NA,in
R3087 T11604 T11602 cc and,male
R3088 T11605 T11602 conj female,male
R3089 T11606 T11600 punct ", ",detected
R309 T2750 T2748 pobj traits,of
R3090 T11607 T11600 advmod respectively,detected
R3091 T11608 T11600 punct ", ",detected
R3092 T11609 T11600 auxpass was,detected
R3093 T11480 T11479 prep in,increase
R3094 T11610 T11600 advmod also,detected
R3095 T11611 T11600 punct .,detected
R3096 T11481 T11480 pobj fat,in
R3097 T11613 T11614 nsubjpass This,expected
R3098 T11483 T11473 acomp dependent,was
R3099 T11615 T11614 auxpass was,expected
R31 T611 T609 conj adiposity,growth
R310 T2751 T2752 advmod commonly,seen
R3100 T11616 T11617 mark since,found
R3101 T11484 T11483 prep on,dependent
R3102 T11485 T11484 pobj hg,on
R3103 T11617 T11614 advcl found,expected
R3104 T11618 T11617 nsubjpass NA,found
R3105 T11486 T11482 punct ;,were
R3106 T11619 T11617 auxpass was,found
R3107 T11620 T11617 advmod previously,found
R3108 T11487 T11482 advmod however,were
R3109 T11621 T11622 aux to,be
R311 T2752 T2750 acl seen,traits
R3110 T11622 T11617 xcomp be,found
R3111 T11623 T11624 det an,indicator
R3112 T11488 T11482 punct ", ",were
R3113 T11624 T11622 attr indicator,be
R3114 T11625 T11624 amod excellent,indicator
R3115 T11489 T11482 nsubj differences,were
R3116 T11626 T11624 prep of,indicator
R3117 T11627 T11628 compound femur,length
R3118 T11628 T11626 pobj length,of
R3119 T11490 T11489 prep in,differences
R312 T2753 T2752 prep in,seen
R3120 T11629 T11630 punct (,0.88
R3121 T11491 T11492 compound femur,length
R3122 T11630 T11622 parataxis 0.88,be
R3123 T11631 T11630 nsubj R2,0.88
R3124 T11632 T11630 punct =,0.88
R3125 T11492 T11490 pobj length,in
R3126 T11633 T11630 punct ),0.88
R3127 T11634 T11622 prep in,be
R3128 T11493 T11482 neg not,were
R3129 T11635 T11636 compound HG,mice
R313 T2754 T2755 det the,population
R3130 T11636 T11634 pobj mice,in
R3131 T11494 T11495 punct [,24
R3132 T11637 T11638 punct [,27
R3133 T11638 T11617 parataxis 27,found
R3134 T11639 T11638 punct ],27
R3135 T11495 T11482 parataxis 24,were
R3136 T11640 T11617 cc and,found
R3137 T11496 T11495 punct ],24
R3138 T11497 T11482 punct .,were
R3139 T11641 T11642 mark as,noted
R314 T2755 T2753 pobj population,in
R3140 T11642 T11643 advcl noted,contains
R3141 T11643 T11617 conj contains,found
R3142 T11644 T11642 advmod above,noted
R3143 T11499 T11500 prep In,increased
R3144 T11645 T11646 det this,region
R3145 T11646 T11643 nsubj region,contains
R3146 T11647 T11648 det the,QTL
R3147 T11648 T11643 dobj QTL,contains
R3148 T11501 T11499 pobj confirmation,In
R3149 T11649 T11648 compound Feml2,QTL
R315 T2756 T2755 amod human,population
R3150 T11650 T11651 punct [,24
R3151 T11502 T11501 prep of,confirmation
R3152 T11651 T11643 parataxis 24,contains
R3153 T11652 T11651 punct ],24
R3154 T11653 T11614 punct .,expected
R3155 T11503 T11502 pobj Carfhg2,of
R3156 T11504 T11505 det all,measures
R3157 T11655 T11656 det These,data
R3158 T11656 T11657 nsubj data,confirm
R3159 T11505 T11500 nsubjpass measures,increased
R316 T2757 T2739 punct .,mimic
R3160 T11658 T11659 det the,effects
R3161 T11659 T11657 dobj effects,confirm
R3162 T11660 T11659 prep of,effects
R3163 T11506 T11505 prep of,measures
R3164 T11661 T11660 pobj Carfhg2,of
R3165 T11662 T11659 prep on,effects
R3166 T11507 T11506 pobj adiposity,of
R3167 T11663 T11662 pobj adiposity,on
R3168 T11664 T11659 cc and,effects
R3169 T11665 T11659 conj Feml2,effects
R317 T2759 T2760 compound Complex,traits
R3170 T11508 T11507 prep in,adiposity
R3171 T11666 T11665 prep on,Feml2
R3172 T11667 T11666 pobj length,on
R3173 T11509 T11510 compound HG9,mice
R3174 T11668 T11657 cc and,confirm
R3175 T11669 T11657 conj indicate,confirm
R3176 T11670 T11671 det the,effects
R3177 T11510 T11508 pobj mice,in
R3178 T11671 T11673 nsubj effects,are
R3179 T11672 T11671 amod isolated,effects
R318 T2760 T2761 nsubjpass traits,influenced
R3180 T11673 T11669 advcl are,indicate
R3181 T11511 T11500 auxpass were,increased
R3182 T11674 T11671 prep of,effects
R3183 T11675 T11674 pobj Carfhg2,of
R3184 T11512 T11500 advcl relative,increased
R3185 T11676 T11677 advmod more,significant
R3186 T11677 T11673 acomp significant,are
R3187 T11678 T11679 mark than,observed
R3188 T11513 T11512 prep to,relative
R3189 T11679 T11677 advcl observed,significant
R319 T2762 T2760 punct ", ",traits
R3190 T11680 T11679 advmod originally,observed
R3191 T11681 T11657 punct .,confirm
R3192 T11514 T11515 compound control,mice
R3193 T11685 T11686 prep In,linked
R3194 T11687 T11688 det the,intercross
R3195 T11515 T11513 pobj mice,to
R3196 T11688 T11685 pobj intercross,In
R3197 T11689 T11688 amod original,intercross
R3198 T11516 T11500 punct ;,increased
R3199 T11690 T11691 compound CAST,alleles
R32 T612 T611 cc and,adiposity
R320 T2763 T2764 amod such,as
R3200 T11691 T11686 nsubjpass alleles,linked
R3201 T11692 T11691 prep near,alleles
R3202 T11517 T11500 prep except,increased
R3203 T11693 T11694 nummod 50,cM
R3204 T11694 T11692 pobj cM,near
R3205 T11518 T11517 pobj MFP,except
R3206 T11695 T11691 prep on,alleles
R3207 T11696 T11695 pobj MMU11,on
R3208 T11519 T11518 prep in,MFP
R3209 T11697 T11686 auxpass were,linked
R321 T2764 T2760 prep as,traits
R3210 T11698 T11686 prep with,linked
R3211 T11699 T11700 det a,reduction
R3212 T11520 T11521 preconj both,sexes
R3213 T11700 T11698 pobj reduction,with
R3214 T11701 T11700 prep in,reduction
R3215 T11702 T11701 pobj G29,in
R3216 T11521 T11519 pobj sexes,in
R3217 T11703 T11702 punct ", ",G29
R3218 T11704 T11705 compound carcass,ash
R3219 T11522 T11518 cc and,MFP
R322 T2765 T2766 amod polygenic,growth
R3220 T11705 T11702 conj ash,G29
R3221 T11706 T11705 punct (,ash
R3222 T11523 T11518 conj BMI,MFP
R3223 T11707 T11705 appos ASH,ash
R3224 T11524 T11523 prep in,BMI
R3225 T11708 T11705 punct ),ash
R3226 T11709 T11705 cc and,ash
R3227 T11710 T11711 compound carcass,protein
R3228 T11525 T11524 pobj males,in
R3229 T11711 T11705 conj protein,ash
R323 T2766 T2764 pobj growth,as
R3230 T11712 T11711 punct (,protein
R3231 T11526 T11527 punct (,Table
R3232 T11713 T11711 appos PROT,protein
R3233 T11714 T11686 punct ),linked
R3234 T11715 T11716 punct [,24
R3235 T11527 T11500 parataxis Table,increased
R3236 T11716 T11686 parataxis 24,linked
R3237 T11717 T11716 punct ],24
R3238 T11528 T11527 nummod 5,Table
R3239 T11718 T11686 punct .,linked
R324 T2767 T2766 cc and,growth
R3240 T11529 T11527 punct ),Table
R3241 T11720 T11721 advmod Therefore,measured
R3242 T11722 T11721 punct ", ",measured
R3243 T11723 T11721 nsubj we,measured
R3244 T11724 T11725 det each,component
R3245 T11725 T11721 dobj component,measured
R3246 T11726 T11725 compound carcass,component
R3247 T11530 T11500 punct .,increased
R3248 T11727 T11721 advcl using,measured
R3249 T11728 T11729 amod chemical,analysis
R325 T2768 T2766 conj obesity,growth
R3250 T11729 T11727 dobj analysis,using
R3251 T11532 T11533 prep In,increased
R3252 T11730 T11729 amod compositional,analysis
R3253 T11731 T11727 prep in,using
R3254 T11732 T11733 det the,strains
R3255 T11733 T11731 pobj strains,in
R3256 T11534 T11532 pobj males,In
R3257 T11734 T11733 nmod HGC,strains
R3258 T11735 T11734 punct ", ",HGC
R3259 T11736 T11734 conj HG11,HGC
R326 T2769 T2761 auxpass are,influenced
R3260 T11737 T11736 cc and,HG11
R3261 T11747 T11748 det the,presence
R3262 T11738 T11736 conj HG17,HG11
R3263 T11739 T11721 punct .,measured
R3264 T11748 T11746 pobj presence,on
R3265 T11741 T11742 advmod Originally,was
R3266 T11749 T11748 prep of,presence
R3267 T11743 T11742 punct ", ",was
R3268 T11744 T11742 nsubj Carp2,was
R3269 T11745 T11742 acomp dependent,was
R327 T2770 T2761 agent by,influenced
R3270 T11750 T11749 pobj hg,of
R3271 T11746 T11745 prep on,dependent
R3272 T11751 T11742 cc and,was
R3273 T11752 T11753 det no,effects
R3274 T11753 T11756 nsubjpass effects,detected
R3275 T11754 T11753 amod significant,effects
R3276 T11853 T11847 conj increase,increase
R3277 T11755 T11753 compound sex,effects
R3278 T11854 T11853 amod small,increase
R3279 T11855 T11853 amod suggestive,increase
R328 T2771 T2772 det the,effects
R3280 T11856 T11853 prep in,increase
R3281 T11756 T11742 conj detected,was
R3282 T11857 T11856 pobj NA,in
R3283 T11858 T11859 punct (,0.06
R3284 T11757 T11756 auxpass were,detected
R3285 T11859 T11840 parataxis 0.06,displayed
R3286 T11860 T11859 nsubj P,0.06
R3287 T11861 T11859 punct =,0.06
R3288 T11758 T11759 punct [,24
R3289 T11862 T11859 punct ),0.06
R329 T2772 T2770 pobj effects,by
R3290 T11863 T11840 punct ", ",displayed
R3291 T11864 T11865 mark while,displayed
R3292 T11759 T11742 parataxis 24,was
R3293 T11865 T11840 advcl displayed,displayed
R3294 T11866 T11865 nsubj females,displayed
R3295 T11867 T11868 amod significant,decreases
R3296 T11868 T11865 dobj decreases,displayed
R3297 T11869 T11868 prep in,decreases
R3298 T11870 T11869 pobj NA,in
R3299 T11871 T11840 punct .,displayed
R33 T613 T614 compound carcass,composition
R330 T2773 T2772 amod small,effects
R3300 T11760 T11759 punct ],24
R3301 T11873 T11874 prep In,seen
R3302 T11761 T11742 punct .,was
R3303 T11875 T11873 pobj support,In
R3304 T11876 T11875 prep of,support
R3305 T11877 T11878 det the,QTL
R3306 T11763 T11764 prep In,displayed
R3307 T11878 T11876 pobj QTL,of
R3308 T11879 T11880 npadvmod sex,specific
R3309 T11765 T11763 pobj contrast,In
R331 T2774 T2773 prep to,small
R3310 T11880 T11878 amod specific,QTL
R3311 T11881 T11880 punct -,specific
R3312 T11882 T11883 nmod effects,strain
R3313 T11883 T11884 nmod strain,interactions
R3314 T11766 T11765 prep to,contrast
R3315 T11884 T11874 nsubjpass interactions,seen
R3316 T11885 T11883 prep by,strain
R3317 T11886 T11885 pobj sex,by
R3318 T11767 T11768 det those,results
R3319 T11887 T11888 punct (,0.04
R332 T2775 T2774 amod moderate,to
R3320 T11888 T11884 parataxis 0.04,interactions
R3321 T11768 T11766 pobj results,to
R3322 T11889 T11888 nsubj P,0.04
R3323 T11890 T11888 punct <,0.04
R3324 T11891 T11888 punct ),0.04
R3325 T11769 T11764 punct ", ",displayed
R3326 T11892 T11874 auxpass were,seen
R3327 T11893 T11874 prep for,seen
R3328 T11894 T11895 det the,traits
R3329 T11770 T11771 compound HG11,mice
R333 T2776 T2772 amod direct,effects
R3330 T11895 T11893 pobj traits,for
R3331 T11896 T11895 amod following,traits
R3332 T11897 T11895 compound growth,traits
R3333 T11771 T11764 nsubj mice,displayed
R3334 T11898 T11895 punct : ,traits
R3335 T11899 T11895 appos 3WK,traits
R3336 T11900 T11899 punct ", ",3WK
R3337 T11772 T11773 amod significant,differences
R3338 T11901 T11899 conj 6WK,3WK
R3339 T11902 T11901 punct ", ",6WK
R334 T2777 T2772 prep of,effects
R3340 T11903 T11901 conj 9WK,6WK
R3341 T11773 T11764 dobj differences,displayed
R3342 T11904 T11903 punct ", ",9WK
R3343 T11905 T11903 conj G26,9WK
R3344 T11906 T11905 punct ", ",G26
R3345 T11774 T11773 prep in,differences
R3346 T11907 T11905 conj G29,G26
R3347 T11908 T11907 cc and,G29
R3348 T11909 T11907 conj NA,G29
R3349 T11910 T11911 punct (,shown
R335 T2778 T2779 amod quantitative,loci
R3350 T11911 T11874 parataxis shown,seen
R3351 T11912 T11911 nsubj data,shown
R3352 T11913 T11911 neg not,shown
R3353 T11775 T11774 pobj growth,in
R3354 T11914 T11911 punct ),shown
R3355 T11915 T11874 punct .,seen
R3356 T11776 T11775 cc and,growth
R3357 T11917 T11918 det The,basis
R3358 T11918 T11919 nsubj basis,was
R3359 T11777 T11775 conj obesity,growth
R336 T2779 T2777 pobj loci,of
R3360 T11920 T11918 prep of,basis
R3361 T11921 T11922 det each,interaction
R3362 T11778 T11764 prep between,displayed
R3363 T11922 T11920 pobj interaction,of
R3364 T11923 T11924 det an,increase
R3365 T11779 T11780 det the,sexes
R3366 T11924 T11919 attr increase,was
R3367 T11925 T11924 prep in,increase
R3368 T11926 T11927 det the,males
R3369 T11780 T11778 pobj sexes,between
R337 T2780 T2779 compound trait,loci
R3370 T11927 T11925 pobj males,in
R3371 T11781 T11764 punct .,displayed
R3372 T11928 T11924 cc and,increase
R3373 T11929 T11930 det a,decrease
R3374 T11930 T11924 conj decrease,increase
R3375 T11931 T11930 prep in,decrease
R3376 T11783 T11784 prep In,demonstrated
R3377 T11932 T11931 pobj females,in
R3378 T11933 T11919 punct .,was
R3379 T11935 T11936 prep In,observed
R338 T2781 T2779 punct (,loci
R3380 T11785 T11783 amod general,In
R3381 T11937 T11938 poss our,analysis
R3382 T11938 T11935 pobj analysis,In
R3383 T11939 T11938 prep of,analysis
R3384 T11786 T11784 punct ", ",demonstrated
R3385 T11940 T11941 det the,strains
R3386 T11941 T11939 pobj strains,of
R3387 T11942 T11941 nmod HGC,strains
R3388 T11787 T11784 nsubj males,demonstrated
R3389 T11943 T11942 punct ", ",HGC
R339 T2782 T2779 appos QTL,loci
R3390 T11944 T11942 conj HG11,HGC
R3391 T11788 T11789 det a,increase
R3392 T11945 T11944 cc and,HG11
R3393 T11946 T11944 conj HG17,HG11
R3394 T11947 T11936 punct ", ",observed
R3395 T11789 T11784 dobj increase,demonstrated
R3396 T11948 T11949 amod concordant,results
R3397 T11949 T11936 nsubjpass results,observed
R3398 T11950 T11936 auxpass were,observed
R3399 T11951 T11936 advcl measuring,observed
R34 T614 T611 conj composition,adiposity
R340 T2783 T2779 punct ),loci
R3400 T11952 T11951 dobj adiposity,measuring
R3401 T11953 T11951 advcl using,measuring
R3402 T11954 T11955 amod chemical,extraction
R3403 T11955 T11953 dobj extraction,using
R3404 T11956 T11955 compound lipid,extraction
R3405 T11790 T11791 nummod 5,%
R3406 T11957 T11953 cc and,using
R3407 T11958 T11953 conj weighing,using
R3408 T11791 T11789 compound %,increase
R3409 T11792 T11784 cc and,demonstrated
R341 T2784 T2779 punct ", ",loci
R3410 T11959 T11960 compound fat,pad
R3411 T11960 T11961 compound pad,mass
R3412 T11793 T11794 nsubj females,decrease
R3413 T11961 T11958 dobj mass,weighing
R3414 T11962 T11936 punct .,observed
R3415 T11794 T11784 conj decrease,demonstrated
R3416 T11964 T11965 det The,correlation
R3417 T11795 T11794 det a,decrease
R3418 T11965 T11967 nsubj correlation,was
R3419 T11796 T11797 nummod 5,%
R342 T2785 T2779 conj epistasis,loci
R3420 T11966 T11965 amod phenotypic,correlation
R3421 T11797 T11794 compound %,decrease
R3422 T11968 T11965 prep between,correlation
R3423 T11969 T11970 compound carcass,fat
R3424 T11798 T11794 prep in,decrease
R3425 T11970 T11968 pobj fat,between
R3426 T11971 T11970 punct (,fat
R3427 T11799 T11800 det all,traits
R3428 T11972 T11970 appos FAT,fat
R3429 T11973 T11965 punct ),correlation
R343 T2786 T2785 prep between,epistasis
R3430 T11800 T11798 pobj traits,in
R3431 T11974 T11965 prep as,correlation
R3432 T11975 T11976 det a,percent
R3433 T11801 T11802 npadvmod growth,related
R3434 T11976 T11974 pobj percent,as
R3435 T11977 T11976 prep of,percent
R3436 T11978 T11979 det the,weight
R3437 T11802 T11800 amod related,traits
R3438 T11979 T11977 pobj weight,of
R3439 T11980 T11979 amod empty,weight
R344 T2787 T2788 compound QTL,alleles
R3440 T11803 T11802 punct -,related
R3441 T11981 T11979 compound carcass,weight
R3442 T11982 T11979 punct (,weight
R3443 T11983 T11979 appos ECW,weight
R3444 T11804 T11805 punct (,Table
R3445 T11984 T11983 punct ;,ECW
R3446 T11985 T11983 appos weight,ECW
R3447 T11986 T11985 prep of,weight
R3448 T11805 T11784 parataxis Table,demonstrated
R3449 T11987 T11988 amod total,body
R345 T2788 T2786 pobj alleles,between
R3450 T11988 T11986 pobj body,of
R3451 T11989 T11985 punct (,weight
R3452 T11990 T11985 prep including,weight
R3453 T11991 T11990 pobj organs,including
R3454 T11992 T11985 punct ),weight
R3455 T11993 T11985 cc minus,weight
R3456 T11806 T11805 nummod 4,Table
R3457 T11994 T11995 det the,head
R3458 T11995 T11985 conj head,weight
R3459 T11996 T11995 cc and,head
R346 T2789 T2785 punct ", ",epistasis
R3460 T11807 T11805 punct ),Table
R3461 T11997 T11998 amod gastrointestinal,tract
R3462 T11998 T11995 conj tract,head
R3463 T11999 T11985 punct ),weight
R3464 T11808 T11784 punct .,demonstrated
R3465 T12000 T11965 punct (,correlation
R3466 T12001 T12002 compound %,FAT
R3467 T12002 T11965 appos FAT,correlation
R3468 T11810 T11811 nsubj Most,were
R3469 T12003 T11965 punct ),correlation
R347 T2790 T2791 amod environmental,perturbations
R3470 T12004 T11965 acl determined,correlation
R3471 T12005 T12004 prep by,determined
R3472 T11812 T11810 prep of,Most
R3473 T12006 T12007 amod chemical,analysis
R3474 T12007 T12005 pobj analysis,by
R3475 T12008 T12007 cc and,analysis
R3476 T12009 T12007 conj AI,analysis
R3477 T11813 T11814 det these,differences
R3478 T12010 T12004 punct ", ",determined
R3479 T11814 T11812 pobj differences,of
R348 T2791 T2785 conj perturbations,epistasis
R3480 T12011 T12004 advcl using,determined
R3481 T12012 T12011 dobj data,using
R3482 T12013 T12012 prep from,data
R3483 T12014 T12015 det all,lines
R3484 T11815 T11811 punct ", ",were
R3485 T12015 T12013 pobj lines,from
R3486 T12016 T12015 nummod three,lines
R3487 T12017 T12015 punct (,lines
R3488 T11816 T11811 advmod however,were
R3489 T12018 T12015 appos HGC,lines
R349 T2792 T2791 cc and,perturbations
R3490 T12019 T12018 punct ", ",HGC
R3491 T12020 T12018 conj HG11,HGC
R3492 T11817 T11811 punct ", ",were
R3493 T12021 T12020 cc and,HG11
R3494 T12022 T12020 conj HG17,HG11
R3495 T11818 T11811 neg not,were
R3496 T12023 T11967 punct ),was
R3497 T12024 T11967 punct ", ",was
R3498 T12025 T11967 attr 0.92,was
R3499 T11819 T11811 acomp significant,were
R35 T615 T598 auxpass were,identified
R350 T2793 T2794 compound QTL,environment
R3500 T12026 T11967 punct .,was
R3501 T11820 T11811 prep at,were
R3502 T12028 T12029 det These,data
R3503 T12029 T12030 nsubj data,suggest
R3504 T12031 T12032 mark that,is
R3505 T12032 T12030 ccomp is,suggest
R3506 T12033 T12034 amod individual,dissection
R3507 T11821 T11822 det a,0.005
R3508 T12034 T12032 nsubj dissection,is
R3509 T12035 T12036 compound fat,pad
R351 T2794 T2796 compound environment,interactions
R3510 T12036 T12034 compound pad,dissection
R3511 T12037 T12038 det an,proxy
R3512 T11822 T11820 pobj 0.005,at
R3513 T12038 T12032 attr proxy,is
R3514 T12039 T12038 amod excellent,proxy
R3515 T11823 T11822 amod critical,0.005
R3516 T12040 T12038 prep for,proxy
R3517 T12041 T12040 pcomp measuring,for
R3518 T12042 T12043 amod whole,body
R3519 T11824 T11822 nsubj P,0.005
R352 T2795 T2794 punct -,environment
R3520 T12043 T12044 compound body,adiposity
R3521 T12044 T12041 dobj adiposity,measuring
R3522 T12045 T12032 cc and,is
R3523 T11825 T11822 punct <,0.005
R3524 T12046 T12032 conj provides,is
R3525 T12047 T12048 det a,technique
R3526 T11826 T11811 punct ", ",were
R3527 T12048 T12046 dobj technique,provides
R3528 T11827 T11828 mark although,were
R3529 T12049 T12050 advmod much,more
R353 T2796 T2791 conj interactions,perturbations
R3530 T12050 T12051 advmod more,sensitive
R3531 T11828 T11811 advcl were,were
R3532 T12051 T12048 amod sensitive,technique
R3533 T11829 T11830 advmod almost,all
R3534 T12052 T12053 aux to,measure
R3535 T12053 T12048 advcl measure,technique
R3536 T12054 T12055 compound fat,accumulation
R3537 T11830 T11828 nsubj all,were
R3538 T12055 T12053 dobj accumulation,measure
R3539 T12056 T12053 prep in,measure
R354 T2797 T2761 punct .,influenced
R3540 T12057 T12058 amod specific,regions
R3541 T11831 T11828 prep at,were
R3542 T12058 T12056 pobj regions,in
R3543 T12059 T12058 compound body,regions
R3544 T11832 T11833 det a,0.05
R3545 T12060 T12030 punct .,suggest
R3546 T11833 T11831 pobj 0.05,at
R3547 T12062 T12063 compound HG11,females
R3548 T12063 T12064 nsubj females,displayed
R3549 T11834 T11833 amod nominal,0.05
R355 T2799 T2800 prep To,localized
R3550 T11835 T11833 nsubj P,0.05
R3551 T11836 T11833 punct <,0.05
R3552 T12065 T12066 amod slight,increases
R3553 T11837 T11811 punct .,were
R3554 T12066 T12064 dobj increases,displayed
R3555 T12067 T12066 prep in,increases
R3556 T12068 T12069 det all,pads
R3557 T12069 T12067 pobj pads,in
R3558 T12070 T12069 compound fat,pads
R3559 T12071 T12069 punct (,pads
R356 T2800 T2810 ccomp localized,made
R3560 T12072 T12069 prep except,pads
R3561 T11839 T11840 advcl Following,displayed
R3562 T12073 T12072 pobj MFP,except
R3563 T12074 T12069 punct ),pads
R3564 T12075 T12069 cc and,pads
R3565 T12076 T12069 conj AI,pads
R3566 T11841 T11842 det the,trend
R3567 T12077 T12064 punct ", ",displayed
R3568 T12078 T12079 mark although,was
R3569 T12079 T12064 advcl was,displayed
R357 T2801 T2799 pobj date,To
R3570 T12080 T12079 punct ", ",was
R3571 T12081 T12082 advmod only,increase
R3572 T11842 T11839 dobj trend,Following
R3573 T12082 T12079 nsubj increase,was
R3574 T12083 T12082 det the,increase
R3575 T12084 T12085 nummod 16.5,%
R3576 T12085 T12082 compound %,increase
R3577 T11843 T11842 amod same,trend
R3578 T12086 T12082 prep in,increase
R3579 T12087 T12086 pobj AI,in
R358 T2802 T2803 amod numerous,QTL
R3580 T12088 T12079 acomp significant,was
R3581 T11844 T11840 punct ", ",displayed
R3582 T12089 T12090 punct (,Table
R3583 T12090 T12079 parataxis Table,was
R3584 T12091 T12090 nummod 5,Table
R3585 T12092 T12090 punct ),Table
R3586 T11845 T11840 nsubj males,displayed
R3587 T12093 T12064 punct .,displayed
R3588 T11846 T11847 det an,increase
R3589 T12095 T12096 prep In,show
R359 T2803 T2800 nsubjpass QTL,localized
R3590 T12097 T12095 pobj contrast,In
R3591 T12098 T12096 punct ", ",show
R3592 T12099 T12100 compound HG11,males
R3593 T11847 T11840 dobj increase,displayed
R3594 T12100 T12096 nsubj males,show
R3595 T12101 T12096 aux did,show
R3596 T12102 T12096 neg not,show
R3597 T11848 T11847 prep in,increase
R3598 T12103 T12104 det a,difference
R3599 T12104 T12096 dobj difference,show
R36 T616 T598 advmod previously,identified
R360 T2804 T2805 nmod mouse,growth
R3600 T12105 T12104 prep in,difference
R3601 T11849 T11850 compound tail,length
R3602 T12106 T12107 compound fat,mass
R3603 T12107 T12105 pobj mass,in
R3604 T12108 T12104 acl leading,difference
R3605 T11850 T11848 pobj length,in
R3606 T12109 T12108 prep to,leading
R3607 T12110 T12111 det a,interaction
R3608 T12111 T12109 pobj interaction,to
R3609 T12112 T12111 amod significant,interaction
R361 T2805 T2803 nmod growth,QTL
R3610 T12113 T12111 nmod strain,interaction
R3611 T12114 T12113 prep by,strain
R3612 T12115 T12114 pobj sex,by
R3613 T12116 T12117 punct (,0.008
R3614 T12117 T12111 parataxis 0.008,interaction
R3615 T11851 T11847 cc and,increase
R3616 T12118 T12117 nsubj P,0.008
R3617 T12119 T12117 punct =,0.008
R3618 T12120 T12117 punct ),0.008
R3619 T11852 T11853 det a,increase
R362 T2806 T2805 cc and,growth
R3620 T12121 T12111 prep for,interaction
R3621 T12122 T12121 pobj AI,for
R3622 T12123 T12124 punct (,shown
R3623 T12124 T12108 parataxis shown,leading
R3624 T12125 T12124 nsubj data,shown
R3625 T12170 T12169 pobj ECW,of
R3626 T12126 T12124 neg not,shown
R3627 T12127 T12124 punct ),shown
R3628 T12128 T12096 punct .,show
R3629 T12130 T12131 advcl Identical,displayed
R363 T2807 T2805 conj obesity,growth
R3630 T12132 T12130 prep to,Identical
R3631 T12171 T12168 punct (,percent
R3632 T12133 T12134 det the,results
R3633 T12134 T12132 pobj results,to
R3634 T12172 T12173 compound %,ASH
R3635 T12135 T12134 acl obtained,results
R3636 T12173 T12168 appos ASH,percent
R3637 T12136 T12135 advcl using,obtained
R3638 T12174 T12158 punct ),had
R3639 T12137 T12138 compound fat,pad
R364 T2808 T2800 aux have,localized
R3640 T12138 T12139 compound pad,weights
R3641 T12139 T12136 dobj weights,using
R3642 T12175 T12158 cc and,had
R3643 T12140 T12131 punct ;,displayed
R3644 T12141 T12142 amod female,carcasses
R3645 T12142 T12131 nsubj carcasses,displayed
R3646 T12176 T12177 amod female,carcasses
R3647 T12143 T12142 compound HG11,carcasses
R3648 T12144 T12145 det an,increase
R3649 T12177 T12178 nsubj carcasses,displayed
R365 T2809 T2800 auxpass been,localized
R3650 T12145 T12131 dobj increase,displayed
R3651 T12146 T12145 prep in,increase
R3652 T12147 T12148 compound %,FAT
R3653 T12148 T12146 pobj FAT,in
R3654 T12149 T12150 punct (,Table
R3655 T12178 T12158 conj displayed,had
R3656 T12150 T12131 parataxis Table,displayed
R3657 T12151 T12150 nummod 6,Table
R3658 T12179 T12180 amod lower,levels
R3659 T12152 T12150 punct ),Table
R366 T2811 T2812 punct [,2
R3660 T12153 T12131 punct .,displayed
R3661 T12155 T12156 nmod HG11,carcasses
R3662 T12180 T12178 dobj levels,displayed
R3663 T12181 T12180 prep of,levels
R3664 T12156 T12158 nsubj carcasses,had
R3665 T12182 T12181 pobj H2O,of
R3666 T12157 T12156 amod male,carcasses
R3667 T12183 T12182 cc and,H2O
R3668 T12159 T12160 amod higher,levels
R3669 T12160 T12158 dobj levels,had
R367 T2812 T2800 parataxis 2,localized
R3670 T12161 T12162 compound carcass,ash
R3671 T12184 T12182 conj ASH,H2O
R3672 T12162 T12160 appos ash,levels
R3673 T12163 T12162 punct (,ash
R3674 T12164 T12162 appos ASH,ash
R3675 T12185 T12186 punct (,Table
R3676 T12165 T12160 punct ),levels
R3677 T12166 T12160 prep as,levels
R3678 T12186 T12178 parataxis Table,displayed
R3679 T12167 T12168 det a,percent
R368 T2813 T2812 nummod 1,2
R3680 T12168 T12166 pobj percent,as
R3681 T12169 T12168 prep of,percent
R3682 T12187 T12186 nummod 6,Table
R3683 T12188 T12186 punct ),Table
R3684 T12189 T12178 punct .,displayed
R3685 T12276 T12274 amod specific,QTL
R3686 T12191 T12192 nmod Strains,interactions
R3687 T12277 T12276 punct -,specific
R3688 T12278 T12274 prep with,QTL
R3689 T12279 T12280 amod opposing,action
R369 T2814 T2812 punct ",",2
R3690 T12280 T12278 pobj action,with
R3691 T12281 T12266 punct .,be
R3692 T12192 T12195 nsubjpass interactions,identified
R3693 T12193 T12191 prep by,Strains
R3694 T12194 T12193 pobj sex,by
R3695 T12285 T12286 prep In,associated
R3696 T12287 T12288 det the,intercross
R3697 T12196 T12197 punct (,0.005
R3698 T12288 T12285 pobj intercross,In
R3699 T12289 T12288 amod original,intercross
R37 T617 T598 prep on,identified
R370 T2815 T2812 punct ],2
R3700 T12197 T12192 parataxis 0.005,interactions
R3701 T12290 T12291 compound CAST,alleles
R3702 T12291 T12286 nsubjpass alleles,associated
R3703 T12292 T12291 prep at,alleles
R3704 T12198 T12197 nsubj P,0.005
R3705 T12293 T12294 compound MMU17,markers
R3706 T12294 T12292 pobj markers,at
R3707 T12295 T12286 auxpass were,associated
R3708 T12199 T12197 punct <,0.005
R3709 T12296 T12286 prep with,associated
R371 T2816 T2810 punct ", ",made
R3710 T12297 T12296 pobj decreases,with
R3711 T12298 T12297 prep in,decreases
R3712 T12299 T12300 compound femur,length
R3713 T12300 T12298 pobj length,in
R3714 T12301 T12300 punct ", ",length
R3715 T12302 T12300 conj ASH,length
R3716 T12303 T12302 cc and,ASH
R3717 T12200 T12197 punct ),0.005
R3718 T12304 T12302 conj PROT,ASH
R3719 T12305 T12306 punct [,24
R372 T2817 T2810 advmod however,made
R3720 T12201 T12195 auxpass were,identified
R3721 T12306 T12286 parataxis 24,associated
R3722 T12202 T12195 prep for,identified
R3723 T12307 T12306 punct ],24
R3724 T12203 T12202 pobj H2O,for
R3725 T12308 T12286 cc and,associated
R3726 T12309 T12310 amod similar,results
R3727 T12310 T12311 nsubjpass results,seen
R3728 T12204 T12203 punct ", ",H2O
R3729 T12311 T12286 conj seen,associated
R373 T2818 T2810 punct ", ",made
R3730 T12312 T12311 auxpass were,seen
R3731 T12313 T12311 prep in,seen
R3732 T12205 T12206 compound %,H2O
R3733 T12314 T12315 compound HG17,mice
R3734 T12315 T12313 pobj mice,in
R3735 T12206 T12203 conj H2O,H2O
R3736 T12316 T12286 punct .,associated
R3737 T12207 T12206 punct ", ",H2O
R3738 T12318 T12319 advmod Interestingly,were
R3739 T12320 T12319 punct ", ",were
R374 T2819 T2820 amod little,progress
R3740 T12208 T12209 compound %,FAT
R3741 T12321 T12322 det both,sexes
R3742 T12322 T12319 nsubj sexes,were
R3743 T12323 T12319 acomp heavier,were
R3744 T12209 T12206 conj FAT,H2O
R3745 T12324 T12323 prep at,heavier
R3746 T12325 T12324 pobj 2WK,at
R3747 T12326 T12327 punct (,0.0342
R3748 T12210 T12209 punct ", ",FAT
R3749 T12327 T12323 parataxis 0.0342,heavier
R375 T2820 T2810 nsubjpass progress,made
R3750 T12328 T12329 dep males,0.0045
R3751 T12211 T12209 conj ASH,FAT
R3752 T12329 T12327 dep 0.0045,0.0342
R3753 T12330 T12329 punct ", ",0.0045
R3754 T12212 T12211 cc and,ASH
R3755 T12331 T12329 nsubj P,0.0045
R3756 T12332 T12329 punct =,0.0045
R3757 T12333 T12327 punct ;,0.0342
R3758 T12213 T12211 conj PROT,ASH
R3759 T12334 T12327 dep females,0.0342
R376 T2821 T2810 aux has,made
R3760 T12335 T12327 punct ", ",0.0342
R3761 T12214 T12215 punct (,shown
R3762 T12336 T12327 nsubj P,0.0342
R3763 T12337 T12327 punct =,0.0342
R3764 T12338 T12327 punct ),0.0342
R3765 T12339 T12323 punct ", ",heavier
R3766 T12340 T12323 cc but,heavier
R3767 T12341 T12323 conj lighter,heavier
R3768 T12342 T12341 prep at,lighter
R3769 T12215 T12195 parataxis shown,identified
R377 T2822 T2810 auxpass been,made
R3770 T12343 T12342 pobj 9WK,at
R3771 T12344 T12319 punct ", ",were
R3772 T12345 T12319 advcl leading,were
R3773 T12216 T12215 nsubj data,shown
R3774 T12346 T12345 prep to,leading
R3775 T12347 T12348 advmod substantially,lower
R3776 T12348 T12349 amod lower,G26
R3777 T12217 T12215 neg not,shown
R3778 T12349 T12346 pobj G26,to
R3779 T12350 T12349 cc and,G26
R378 T2823 T2810 prep in,made
R3780 T12218 T12215 punct ),shown
R3781 T12351 T12349 conj G29,G26
R3782 T12352 T12353 punct (,Table
R3783 T12353 T12319 parataxis Table,were
R3784 T12219 T12195 punct .,identified
R3785 T12354 T12353 nummod 4,Table
R3786 T12355 T12353 punct ),Table
R3787 T12356 T12319 punct .,were
R3788 T12221 T12222 mark If,is
R3789 T12358 T12359 prep In,ranged
R379 T2824 T2823 pcomp determining,in
R3790 T12360 T12358 amod general,In
R3791 T12222 T12228 advcl is,be
R3792 T12361 T12362 compound growth,differences
R3793 T12362 T12359 nsubj differences,ranged
R3794 T12223 T12224 det the,phenotype
R3795 T12363 T12359 prep between,ranged
R3796 T12364 T12365 nummod 5,%
R3797 T12365 T12363 pobj %,between
R3798 T12224 T12222 nsubj phenotype,is
R3799 T12366 T12365 cc and,%
R38 T618 T619 compound mouse,chromosomes
R380 T2825 T2826 det the,nature
R3800 T12367 T12368 nummod 15,%
R3801 T12368 T12365 conj %,%
R3802 T12225 T12224 amod aggregate,phenotype
R3803 T12369 T12365 amod lower,%
R3804 T12370 T12359 prep in,ranged
R3805 T12226 T12224 prep in,phenotype
R3806 T12371 T12372 amod congenic,mice
R3807 T12372 T12370 pobj mice,in
R3808 T12227 T12226 pobj HG11,in
R3809 T12373 T12359 punct .,ranged
R381 T2826 T2824 dobj nature,determining
R3810 T12375 T12376 det Both,sexes
R3811 T12229 T12222 prep due,is
R3812 T12376 T12377 nsubj sexes,had
R3813 T12378 T12379 amod significant,reductions
R3814 T12379 T12377 dobj reductions,had
R3815 T12380 T12379 prep in,reductions
R3816 T12381 T12382 compound length,traits
R3817 T12230 T12229 pcomp to,due
R3818 T12231 T12232 det a,locus
R3819 T12382 T12380 pobj traits,in
R382 T2827 T2826 amod specific,nature
R3820 T12232 T12229 pobj locus,due
R3821 T12383 T12377 advcl relative,had
R3822 T12384 T12383 prep to,relative
R3823 T12385 T12386 compound control,mice
R3824 T12233 T12232 amod single,locus
R3825 T12386 T12384 pobj mice,to
R3826 T12387 T12377 punct .,had
R3827 T12234 T12228 punct ", ",be
R3828 T12389 T12390 nsubjpass NA,reduced
R3829 T12235 T12236 poss its,function
R383 T2828 T2826 prep of,nature
R3830 T12391 T12390 auxpass was,reduced
R3831 T12392 T12390 prep by,reduced
R3832 T12393 T12394 nummod 2.7,%
R3833 T12236 T12228 nsubj function,be
R3834 T12394 T12392 pobj %,by
R3835 T12395 T12396 punct (,0.0186
R3836 T12237 T12228 aux may,be
R3837 T12238 T12239 aux to,disrupt
R3838 T12396 T12394 parataxis 0.0186,%
R3839 T12397 T12396 nsubj P,0.0186
R384 T2829 T2830 det the,variants
R3840 T12239 T12228 xcomp disrupt,be
R3841 T12398 T12396 punct =,0.0186
R3842 T12399 T12396 punct ),0.0186
R3843 T12400 T12394 cc and,%
R3844 T12240 T12241 compound energy,partitioning
R3845 T12401 T12402 nummod 3.4,%
R3846 T12402 T12394 conj %,%
R3847 T12403 T12390 prep in,reduced
R3848 T12241 T12239 dobj partitioning,disrupt
R3849 T12404 T12403 pobj males,in
R385 T2830 T2828 pobj variants,of
R3850 T12405 T12404 cc and,males
R3851 T12242 T12239 prep by,disrupt
R3852 T12406 T12404 conj females,males
R3853 T12407 T12390 punct ", ",reduced
R3854 T12243 T12242 pcomp decreasing,by
R3855 T12408 T12390 advmod respectively,reduced
R3856 T12409 T12410 punct (,Table
R3857 T12410 T12390 parataxis Table,reduced
R3858 T12244 T12245 det the,deposition
R3859 T12411 T12410 nummod 4,Table
R386 T2831 T2830 amod underlying,variants
R3860 T12412 T12410 punct ),Table
R3861 T12245 T12243 dobj deposition,decreasing
R3862 T12413 T12390 punct .,reduced
R3863 T12246 T12245 prep of,deposition
R3864 T12415 T12416 prep In,reduced
R3865 T12417 T12415 pobj addition,In
R3866 T12418 T12416 punct ", ",reduced
R3867 T12419 T12416 nsubjpass tail,reduced
R3868 T12420 T12416 auxpass was,reduced
R3869 T12421 T12416 prep by,reduced
R387 T2832 T2830 amod genetic,variants
R3870 T12247 T12248 amod lean,tissue
R3871 T12422 T12423 advmod approximately,6
R3872 T12423 T12424 nummod 6,%
R3873 T12424 T12421 pobj %,by
R3874 T12248 T12246 pobj tissue,of
R3875 T12425 T12416 prep in,reduced
R3876 T12426 T12427 det both,sexes
R3877 T12249 T12243 cc and,decreasing
R3878 T12427 T12425 pobj sexes,in
R3879 T12428 T12429 punct (,Table
R388 T2833 T2810 punct .,made
R3880 T12429 T12416 parataxis Table,reduced
R3881 T12250 T12243 conj increasing,decreasing
R3882 T12430 T12429 nummod 4,Table
R3883 T12431 T12429 punct ),Table
R3884 T12251 T12252 compound lipid,accumulation
R3885 T12432 T12416 punct .,reduced
R3886 T12252 T12250 dobj accumulation,increasing
R3887 T12434 T12435 prep In,displayed
R3888 T12436 T12434 amod general,In
R3889 T12253 T12252 prep in,accumulation
R389 T2835 T2836 nummod One,resource
R3890 T12437 T12435 punct ", ",displayed
R3891 T12438 T12439 compound HG17,mice
R3892 T12254 T12253 pobj females,in
R3893 T12439 T12435 nsubj mice,displayed
R3894 T12440 T12435 dobj increases,displayed
R3895 T12441 T12440 prep in,increases
R3896 T12255 T12243 punct ", ",decreasing
R3897 T12442 T12443 det all,pads
R3898 T12443 T12441 pobj pads,in
R3899 T12444 T12443 compound fat,pads
R39 T619 T617 pobj chromosomes,on
R390 T2836 T2837 nsubj resource,are
R3900 T12256 T12257 mark while,having
R3901 T12445 T12443 punct (,pads
R3902 T12446 T12443 prep except,pads
R3903 T12257 T12243 advcl having,decreasing
R3904 T12447 T12446 pobj MFP,except
R3905 T12448 T12443 punct ),pads
R3906 T12258 T12259 det the,action
R3907 T12449 T12443 punct ", ",pads
R3908 T12450 T12443 conj TF,pads
R3909 T12451 T12450 cc and,TF
R391 T2838 T2836 acl used,resource
R3910 T12259 T12257 dobj action,having
R3911 T12452 T12450 conj AI,TF
R3912 T12453 T12454 punct (,Table
R3913 T12260 T12259 amod opposite,action
R3914 T12454 T12435 parataxis Table,displayed
R3915 T12455 T12454 nummod 5,Table
R3916 T12456 T12454 punct ),Table
R3917 T12261 T12257 prep in,having
R3918 T12457 T12435 punct .,displayed
R3919 T12459 T12460 advmod However,were
R392 T2839 T2840 aux to,map
R3920 T12461 T12460 punct ", ",were
R3921 T12462 T12460 nsubj none,were
R3922 T12262 T12261 pobj males,in
R3923 T12463 T12462 prep of,none
R3924 T12464 T12465 det these,differences
R3925 T12465 T12463 pobj differences,of
R3926 T12263 T12228 punct .,be
R3927 T12466 T12460 acomp significant,were
R3928 T12467 T12460 prep at,were
R3929 T12265 T12266 advmod However,be
R393 T2840 T2838 advcl map,used
R3930 T12468 T12469 amod critical,0.005
R3931 T12469 T12467 pobj 0.005,at
R3932 T12470 T12469 nsubj P,0.005
R3933 T12471 T12469 punct <,0.005
R3934 T12267 T12266 punct ", ",be
R3935 T12472 T12460 punct .,were
R3936 T12474 T12475 prep In,possessed
R3937 T12268 T12266 nsubj it,be
R3938 T12476 T12474 pobj addition,In
R3939 T12477 T12475 punct ", ",possessed
R394 T2841 T2840 advmod fine,map
R3940 T12269 T12266 aux may,be
R3941 T12478 T12479 nmod HG17,carcasses
R3942 T12479 T12475 nsubj carcasses,possessed
R3943 T12480 T12479 amod male,carcasses
R3944 T12270 T12266 advmod also,be
R3945 T12481 T12482 amod lower,levels
R3946 T12482 T12475 dobj levels,possessed
R3947 T12483 T12482 prep of,levels
R3948 T12271 T12266 prep due,be
R3949 T12272 T12271 pcomp to,due
R395 T2842 T2840 dobj QTL,map
R3950 T12484 T12483 pobj H2O,of
R3951 T12485 T12484 cc and,H2O
R3952 T12486 T12484 conj ASH,H2O
R3953 T12273 T12274 amod distinct,QTL
R3954 T12274 T12271 pobj QTL,due
R3955 T12275 T12276 npadvmod sex,specific
R3956 T12487 T12475 punct ", ",possessed
R3957 T12488 T12489 mark while,contained
R3958 T12489 T12475 advcl contained,possessed
R3959 T12490 T12491 amod female,carcasses
R396 T2843 T2844 amod congenic,strains
R3960 T12491 T12489 nsubj carcasses,contained
R3961 T12492 T12493 amod lower,levels
R3962 T12493 T12489 dobj levels,contained
R3963 T12494 T12493 prep of,levels
R3964 T12495 T12496 compound %,H2O
R3965 T12496 T12494 pobj H2O,of
R3966 T12497 T12496 punct ", ",H2O
R3967 T12498 T12496 conj ASH,H2O
R3968 T12499 T12498 punct ", ",ASH
R3969 T12500 T12501 compound %,ASH
R397 T2844 T2837 attr strains,are
R3970 T12501 T12498 conj ASH,ASH
R3971 T12502 T12501 cc and,ASH
R3972 T12503 T12504 compound %,PROT
R3973 T12504 T12501 conj PROT,ASH
R3974 T12505 T12506 punct (,Table
R3975 T12506 T12475 parataxis Table,possessed
R3976 T12507 T12506 nummod 6,Table
R3977 T12508 T12506 punct ),Table
R3978 T12509 T12475 punct .,possessed
R398 T2903 T2904 amod congenic,analysis
R3987 T13271 T13272 nmod MMU,2
R3988 T13272 T13273 nummod 2,sequencing
R3989 T13274 T13272 punct ", ",2
R399 T2845 T2846 dep which,designed
R3990 T13275 T13272 conj 9,2
R3991 T13276 T13275 punct ", ",9
R3992 T13277 T13275 conj 11,9
R3993 T13278 T13277 cc and,11
R3994 T13279 T13277 conj 17,11
R3995 T13280 T13281 compound hg,modifier
R3996 T13281 T13273 compound modifier,sequencing
R3997 T13282 T13283 compound candidate,gene
R3998 T13283 T13273 compound gene,sequencing
R3999 T13285 T13286 det The,phenotype
R4 T579 T580 nmod growth,QTL
R40 T620 T619 punct (,chromosomes
R400 T2904 T2905 nsubj analysis,method
R4000 T13286 T13288 nsubj phenotype,is
R4001 T13287 T13286 compound HG,phenotype
R4002 T13288 T13289 ccomp is,reasoned
R4003 T13290 T13288 prep due,is
R4004 T13291 T13290 pcomp to,due
R4005 T13292 T13293 det the,deletion
R4006 T13293 T13290 pobj deletion,due
R4007 T13294 T13293 prep of,deletion
R4008 T13295 T13294 pobj Socs2,of
R4009 T13296 T13289 punct ", ",reasoned
R401 T2846 T2844 relcl designed,strains
R4010 T13297 T13289 advmod therefore,reasoned
R4011 T13298 T13289 nsubj we,reasoned
R4012 T13299 T13300 mark that,represent
R4013 T13300 T13289 ccomp represent,reasoned
R4014 T13301 T13300 nsubj QTL,represent
R4015 T13302 T13301 prep on,QTL
R4016 T13303 T13304 nmod MMU,2
R4017 T13304 T13302 pobj 2,on
R4018 T13305 T13304 punct ", ",2
R4019 T13306 T13304 conj 9,2
R402 T2905 T2899 ccomp method,considers
R4020 T13307 T13306 punct ", ",9
R4021 T13308 T13306 conj 11,9
R4022 T13309 T13308 cc and,11
R4023 T13310 T13308 conj 17,11
R4024 T13311 T13301 acl interacting,QTL
R4025 T13312 T13311 prep with,interacting
R4026 T13313 T13312 pobj hg,with
R4027 T13314 T13300 advmod possibly,represent
R4028 T13315 T13300 dobj variation,represent
R4029 T13316 T13315 prep within,variation
R403 T2906 T2905 det an,method
R4030 T13317 T13316 pobj genes,within
R4031 T13318 T13317 acl participating,genes
R4032 T13319 T13318 prep in,participating
R4033 T13320 T13321 amod various,aspects
R4034 T13321 T13319 pobj aspects,in
R4035 T13322 T13321 prep of,aspects
R4036 T13323 T13324 compound Gh,function
R4037 T13324 T13322 pobj function,of
R4038 T13325 T13289 punct .,reasoned
R4039 T13327 T13328 aux To,select
R404 T2847 T2846 auxpass are,designed
R4040 T13328 T13329 advcl select,identified
R4041 T13330 T13331 compound candidate,genes
R4042 T13331 T13328 dobj genes,select
R4043 T13332 T13331 prep for,genes
R4044 T13333 T13332 pobj sequencing,for
R4045 T13334 T13329 nsubj we,identified
R4046 T13335 T13329 dobj genes,identified
R4047 T13336 T13335 acl known,genes
R4048 T13337 T13338 aux to,be
R4049 T13338 T13336 xcomp be,known
R405 T2907 T2905 amod excellent,method
R4050 T13339 T13336 cc or,known
R4051 T13340 T13336 conj potentially,known
R4052 T13341 T13340 dep involved,potentially
R4053 T13342 T13341 prep in,involved
R4054 T13343 T13344 compound Gh,signaling
R4055 T13344 T13342 pobj signaling,in
R4056 T13345 T13336 punct ", ",known
R4057 T13346 T13336 conj are,known
R4058 T13347 T13346 acomp responsive,are
R4059 T13348 T13347 prep to,responsive
R406 T2908 T2909 aux to,confirm
R4060 T13349 T13348 pobj Gh,to
R4061 T13350 T13346 cc or,are
R4062 T13351 T13352 dep that,propagate
R4063 T13352 T13346 conj propagate,are
R4064 T13353 T13354 amod downstream,functions
R4065 T13354 T13352 dobj functions,propagate
R4066 T13355 T13354 compound Gh,functions
R4067 T13356 T13329 punct .,identified
R4068 T13358 T13359 compound Forty,four
R4069 T13359 T13361 nummod four,genes
R407 T2909 T2905 advcl confirm,method
R4070 T13360 T13359 punct -,four
R4071 T13361 T13365 nsubjpass genes,identified
R4072 T13362 T13363 compound hg,modifier
R4073 T13363 T13361 compound modifier,genes
R4074 T13364 T13361 compound candidate,genes
R4075 T13366 T13365 auxpass were,identified
R4076 T13367 T13365 prep from,identified
R4077 T13368 T13369 amod primary,literature
R4078 T13369 T13367 pobj literature,from
R4079 T13370 T13369 punct ", ",literature
R408 T2848 T2849 aux to,convert
R4080 T13371 T13369 conj reviews,literature
R4081 T13372 T13371 cc and,reviews
R4082 T13373 T13374 compound book,chapters
R4083 T13374 T13371 conj chapters,reviews
R4084 T13375 T13365 cc and,identified
R4085 T13376 T13365 conj coordinated,identified
R4086 T13377 T13376 advcl using,coordinated
R4087 T13378 T13379 det the,software
R4088 T13379 T13377 dobj software,using
R4089 T13380 T13379 nmod GenMAPP,software
R409 T2910 T2909 cc and,confirm
R4090 T13381 T13380 punct (,GenMAPP
R4091 T13382 T13383 compound Gene,MicroArray
R4092 T13383 T13384 compound MicroArray,Profiler
R4093 T13384 T13380 appos Profiler,GenMAPP
R4094 T13385 T13384 compound Pathway,Profiler
R4095 T13386 T13379 punct ),software
R4096 T13387 T13388 compound pathway,building
R4097 T13388 T13379 compound building,software
R4098 T13389 T13390 punct (,Figure
R4099 T13390 T13376 parataxis Figure,coordinated
R41 T621 T619 appos MMU,chromosomes
R410 T2911 T2912 advmod subsequently,map
R4100 T13391 T13390 nummod 5,Figure
R4101 T13392 T13390 punct ),Figure
R4102 T13393 T13365 punct .,identified
R4103 T13395 T13396 det The,region
R4104 T13396 T13398 nsubjpass region,sequenced
R4105 T13397 T13396 compound coding,region
R4106 T13399 T13396 prep of,region
R4107 T13400 T13401 det each,gene
R4108 T13401 T13399 pobj gene,of
R4109 T13402 T13398 auxpass was,sequenced
R411 T2849 T2846 advcl convert,designed
R4110 T13403 T13398 prep from,sequenced
R4111 T13404 T13405 det the,strain
R4112 T13405 T13403 pobj strain,from
R4113 T13406 T13405 compound CAST,strain
R4114 T13407 T13398 cc and,sequenced
R4115 T13408 T13398 conj compared,sequenced
R4116 T13409 T13408 prep to,compared
R4117 T13410 T13411 det the,sequence
R4118 T13411 T13409 pobj sequence,to
R4119 T13412 T13413 advmod publicly,available
R412 T2912 T2909 conj map,confirm
R4120 T13413 T13411 amod available,sequence
R4121 T13414 T13411 compound B6,sequence
R4122 T13415 T13416 aux to,identify
R4123 T13416 T13408 advcl identify,compared
R4124 T13417 T13416 dobj polymorphisms,identify
R4125 T13418 T13419 punct (,File
R4126 T13419 T13408 parataxis File,compared
R4127 T13420 T13419 amod Additional,File
R4128 T13421 T13419 nummod 4,File
R4129 T13422 T13419 punct ),File
R413 T2913 T2912 advmod fine,map
R4130 T13423 T13398 punct .,sequenced
R4131 T13425 T13426 det A,total
R4132 T13426 T13427 nsubjpass total,sequenced
R4133 T13428 T13426 prep of,total
R4134 T13429 T13430 nummod 94.492,kbp
R4135 T13430 T13428 pobj kbp,of
R4136 T13431 T13427 auxpass was,sequenced
R4137 T13432 T13433 punct (,CDS
R4138 T13433 T13427 parataxis CDS,sequenced
R4139 T13434 T13435 nummod 75.378,kbp
R414 T2914 T2912 dobj QTL,map
R4140 T13435 T13433 compound kbp,CDS
R4141 T13436 T13433 cc and,CDS
R4142 T13437 T13438 nummod 19.114,Kbp
R4143 T13438 T13439 nmod Kbp,region
R4144 T13439 T13433 conj region,CDS
R4145 T13440 T13438 nummod 5,Kbp
R4146 T13441 T13440 punct ',5
R4147 T13442 T13438 cc and,Kbp
R4148 T13443 T13438 conj 3,Kbp
R4149 T13444 T13443 punct ',3
R415 T2915 T2916 punct [,3
R4150 T13445 T13439 amod untranslated,region
R4151 T13446 T13439 punct (,region
R4152 T13447 T13439 appos UTR,region
R4153 T13448 T13439 punct ),region
R4154 T13449 T13433 punct ),CDS
R4155 T13450 T13427 punct ", ",sequenced
R4156 T13451 T13427 advcl representing,sequenced
R4157 T13452 T13453 nummod "25,083",acids
R4158 T13453 T13451 dobj acids,representing
R4159 T13454 T13453 compound amino,acids
R416 T2850 T2851 det a,trait
R4160 T13455 T13427 punct .,sequenced
R4161 T13457 T13458 nsubj Comparison,identified
R4162 T13459 T13457 prep with,Comparison
R4163 T13460 T13461 det the,assembly
R4164 T13461 T13459 pobj assembly,with
R4165 T13462 T13461 amod public,assembly
R4166 T13463 T13461 compound B6,assembly
R4167 T13464 T13465 punct (,Build
R4168 T13465 T13457 parataxis Build,Comparison
R4169 T13466 T13467 npadvmod May,University
R417 T2916 T2899 parataxis 3,considers
R4170 T13467 T13465 dep University,Build
R4171 T13468 T13466 npadvmod 2004,May
R4172 T13469 T13467 prep of,University
R4173 T13470 T13469 pobj California,of
R4174 T13471 T13467 punct ", ",University
R4175 T13472 T13473 compound Santa,Cruz
R4176 T13473 T13467 npadvmod Cruz,University
R4177 T13474 T13475 punct (,28
R4178 T13475 T13467 parataxis 28,University
R4179 T13476 T13475 dep UCSC,28
R418 T2917 T2916 punct ],3
R4180 T13477 T13475 punct [,28
R4181 T13478 T13475 punct ],28
R4182 T13479 T13475 punct ),28
R4183 T13480 T13481 compound mm5,assembly
R4184 T13481 T13465 dep assembly,Build
R4185 T13482 T13481 compound genome,assembly
R4186 T13483 T13465 punct ", ",Build
R4187 T13484 T13485 compound National,Center
R4188 T13485 T13465 dep Center,Build
R4189 T13486 T13485 prep for,Center
R419 T2851 T2849 dobj trait,convert
R4190 T13487 T13488 compound Biotechnology,Information
R4191 T13488 T13486 pobj Information,for
R4192 T13489 T13485 punct (,Center
R4193 T13490 T13485 appos NCBI,Center
R4194 T13491 T13485 punct ),Center
R4195 T13492 T13465 nummod 33,Build
R4196 T13493 T13465 punct ),Build
R4197 T13494 T13495 nummod 307,polymorphisms
R4198 T13495 T13458 dobj polymorphisms,identified
R4199 T13496 T13495 prep between,polymorphisms
R42 T622 T619 punct ),chromosomes
R420 T2918 T2899 punct .,considers
R4200 T13497 T13496 pobj CAST,between
R4201 T13498 T13497 cc and,CAST
R4202 T13499 T13497 conj B6,CAST
R4203 T13500 T13458 punct .,identified
R4204 T13502 T13503 prep Of,were
R4205 T13504 T13502 pobj these,Of
R4206 T13505 T13503 punct ", ",were
R4207 T13506 T13503 nsubj 295,were
R4208 T13507 T13508 amod single,polymorphisms
R4209 T13508 T13503 attr polymorphisms,were
R421 T2920 T2921 advmod Traditionally,developed
R4210 T13509 T13508 compound nucleotide,polymorphisms
R4211 T13510 T13508 punct (,polymorphisms
R4212 T13511 T13508 appos SNP,polymorphisms
R4213 T13512 T13503 punct ),were
R4214 T13513 T13503 cc and,were
R4215 T13514 T13515 nsubj 12,were
R4216 T13515 T13503 conj were,were
R4217 T13516 T13515 attr insertions,were
R4218 T13517 T13516 cc or,insertions
R4219 T13518 T13516 conj deletions,insertions
R422 T2852 T2851 amod complex,trait
R4220 T13519 T13516 prep in,insertions
R4221 T13520 T13519 pobj CAST,in
R4222 T13521 T13522 punct (,File
R4223 T13522 T13503 parataxis File,were
R4224 T13523 T13522 amod Additional,File
R4225 T13524 T13522 nummod 4,File
R4226 T13525 T13522 punct ),File
R4227 T13526 T13503 punct .,were
R4228 T13528 T13529 predet All,insertions
R4229 T13529 T13531 nsubjpass insertions,located
R423 T2922 T2921 punct ", ",developed
R4230 T13530 T13529 nummod 12,insertions
R4231 T13532 T13529 cc or,insertions
R4232 T13533 T13529 conj deletions,insertions
R4233 T13534 T13531 auxpass were,located
R4234 T13535 T13531 prep within,located
R4235 T13536 T13537 nummod 5,UTRs
R4236 T13537 T13535 pobj UTRs,within
R4237 T13538 T13536 punct ',5
R4238 T13539 T13536 cc and,5
R4239 T13540 T13536 conj 3,5
R424 T2923 T2924 amod congenic,strains
R4240 T13541 T13540 punct ',3
R4241 T13542 T13531 punct .,located
R4242 T13544 T13545 compound Fifty,six
R4243 T13545 T13547 nummod six,SNP
R4244 T13546 T13545 punct -,six
R4245 T13547 T13549 nsubjpass SNP,identified
R4246 T13548 T13547 amod nonsynonomous,SNP
R4247 T13550 T13547 punct (,SNP
R4248 T13551 T13547 appos nsSNP,SNP
R4249 T13552 T13549 punct ),identified
R425 T2853 T2851 amod polygenic,trait
R4250 T13553 T13549 auxpass were,identified
R4251 T13554 T13549 prep in,identified
R4252 T13555 T13556 nummod 14,genes
R4253 T13556 T13554 pobj genes,in
R4254 T13557 T13556 amod different,genes
R4255 T13558 T13559 punct (,File
R4256 T13559 T13549 parataxis File,identified
R4257 T13560 T13559 amod Additional,File
R4258 T13561 T13559 nummod 4,File
R4259 T13562 T13559 punct ),File
R426 T2924 T2921 nsubjpass strains,developed
R4260 T13563 T13549 punct .,identified
R4261 T13565 T13566 nsubj PolyPhen,are
R4262 T13567 T13568 punct [,29
R4263 T13568 T13565 parataxis 29,PolyPhen
R4264 T13569 T13568 punct ],29
R4265 T13570 T13565 cc and,PolyPhen
R4266 T13571 T13565 conj SIFT,PolyPhen
R4267 T13572 T13573 punct [,30
R4268 T13573 T13571 parataxis 30,SIFT
R4269 T13574 T13573 punct ],30
R427 T2925 T2921 auxpass are,developed
R4270 T13575 T13576 compound software,programs
R4271 T13576 T13566 attr programs,are
R4272 T13577 T13576 acl designed,programs
R4273 T13578 T13579 aux to,identify
R4274 T13579 T13577 advcl identify,designed
R4275 T13580 T13579 dobj nsSNP,identify
R4276 T13581 T13582 dep which,alter
R4277 T13582 T13580 relcl alter,nsSNP
R4278 T13583 T13582 advmod potentially,alter
R4279 T13584 T13585 compound protein,function
R428 T2854 T2849 prep into,convert
R4280 T13585 T13582 dobj function,alter
R4281 T13586 T13579 prep by,identify
R4282 T13587 T13586 pcomp evaluating,by
R4283 T13588 T13589 amod evolutionary,conservation
R4284 T13589 T13587 dobj conservation,evaluating
R4285 T13590 T13587 prep at,evaluating
R4286 T13591 T13592 amod specific,residues
R4287 T13592 T13590 pobj residues,at
R4288 T13593 T13594 compound amino,acid
R4289 T13594 T13592 compound acid,residues
R429 T2926 T2921 prep by,developed
R4290 T13595 T13587 advcl using,evaluating
R4291 T13596 T13597 det a,alignment
R4292 T13597 T13595 dobj alignment,using
R4293 T13598 T13599 amod multiple,sequence
R4294 T13599 T13597 compound sequence,alignment
R4295 T13600 T13597 prep of,alignment
R4296 T13601 T13602 compound protein,sequences
R4297 T13602 T13600 pobj sequences,of
R4298 T13603 T13602 amod homologous,sequences
R4299 T13604 T13603 prep to,homologous
R43 T623 T619 appos 1,chromosomes
R430 T2927 T2926 pcomp introgressing,by
R4300 T13605 T13606 det the,query
R4301 T13606 T13604 pobj query,to
R4302 T13607 T13566 punct .,are
R4303 T13609 T13610 advmod When,applied
R4304 T13610 T13611 advcl applied,predicted
R4305 T13612 T13610 prep to,applied
R4306 T13613 T13614 poss our,set
R4307 T13614 T13612 pobj set,to
R4308 T13615 T13614 compound data,set
R4309 T13616 T13611 nsubj PolyPhen,predicted
R431 T2928 T2929 compound QTL,alleles
R4310 T13617 T13616 punct ", ",PolyPhen
R4311 T13618 T13616 conj SIFT,PolyPhen
R4312 T13619 T13618 cc or,SIFT
R4313 T13620 T13621 det both,programs
R4314 T13621 T13618 conj programs,SIFT
R4315 T13622 T13623 mark that,alter
R4316 T13623 T13611 ccomp alter,predicted
R4317 T13624 T13625 quantmod 15,56
R4318 T13625 T13628 nummod 56,nsSNP
R4319 T13626 T13625 quantmod of,56
R432 T2929 T2927 dobj alleles,introgressing
R4320 T13627 T13625 quantmod the,56
R4321 T13628 T13623 nsubj nsSNP,alter
R4322 T13629 T13628 prep in,nsSNP
R4323 T13630 T13631 nummod 9,genes
R4324 T13631 T13629 pobj genes,in
R4325 T13632 T13631 amod different,genes
R4326 T13633 T13623 aux would,alter
R4327 T13634 T13623 advmod possibly,alter
R4328 T13635 T13636 compound protein,function
R4329 T13636 T13623 dobj function,alter
R433 T2855 T2854 pobj one,into
R4330 T13637 T13638 punct (,Table
R4331 T13638 T13611 parataxis Table,predicted
R4332 T13639 T13638 nummod 7,Table
R4333 T13640 T13638 punct ),Table
R4334 T13641 T13611 punct .,predicted
R4337 T17718 T17719 npadvmod Speed,congenic
R4338 T17719 T17720 amod congenic,strains
R4339 T17720 T17721 nsubj strains,provide
R434 T2930 T2929 prep from,alleles
R4340 T17722 T17723 det a,approach
R4341 T17723 T17721 dobj approach,provide
R4342 T17724 T17723 amod powerful,approach
R4343 T17725 T17726 aux to,confirm
R4344 T17726 T17723 acl confirm,approach
R4345 T17727 T17726 cc and,confirm
R4346 T17728 T17729 advmod physically,confine
R4347 T17729 T17726 conj confine,confirm
R4348 T17730 T17729 dobj QTL,confine
R4349 T17731 T17729 prep within,confine
R435 T2931 T2932 det a,strain
R4350 T17732 T17731 pobj intervals,within
R4351 T17733 T17732 acl defined,intervals
R4352 T17734 T17733 prep by,defined
R4353 T17735 T17736 amod molecular,markers
R4354 T17736 T17734 pobj markers,by
R4355 T17737 T17721 punct .,provide
R4356 T17739 T17740 prep In,isolated
R4357 T17741 T17742 det the,study
R4358 T17742 T17739 pobj study,In
R4359 T17743 T17742 amod current,study
R436 T2932 T2930 pobj strain,from
R4360 T17744 T17740 punct ", ",isolated
R4361 T17745 T17746 advmod approximately,20
R4362 T17746 T17747 nummod 20,%
R4363 T17747 T17740 nsubjpass %,isolated
R4364 T17748 T17747 prep of,%
R4365 T17749 T17750 det the,genome
R4366 T17750 T17748 pobj genome,of
R4367 T17751 T17750 compound CAST,genome
R4368 T17752 T17750 acl harboring,genome
R4369 T17753 T17754 advmod all,QTL
R437 T2933 T2932 compound donor,strain
R4370 T17754 T17752 dobj QTL,harboring
R4371 T17755 T17756 advmod previously,detected
R4372 T17756 T17754 amod detected,QTL
R4373 T17757 T17758 nmod growth,composition
R4374 T17758 T17754 compound composition,QTL
R4375 T17759 T17757 cc and,growth
R4376 T17760 T17757 conj carcass,growth
R4377 T17761 T17740 auxpass was,isolated
R4378 T17762 T17740 prep on,isolated
R4379 T17763 T17764 det an,background
R438 T2934 T2932 punct ", ",strain
R4380 T17764 T17762 pobj background,on
R4381 T17765 T17764 nmod HG,background
R4382 T17766 T17765 cc or,HG
R4383 T17767 T17765 conj B6,HG
R4384 T17768 T17740 prep through,isolated
R4385 T17769 T17770 det the,development
R4386 T17770 T17768 pobj development,through
R4387 T17771 T17770 prep of,development
R4388 T17772 T17773 nummod 14,strains
R4389 T17773 T17771 pobj strains,of
R439 T2856 T2857 dep that,is
R4390 T17774 T17775 npadvmod speed,congenic
R4391 T17775 T17773 amod congenic,strains
R4392 T17776 T17740 punct .,isolated
R4393 T17778 T17779 nummod Two,panels
R4394 T17779 T17783 nsubjpass panels,developed
R4395 T17780 T17779 amod distinct,panels
R4396 T17781 T17782 npadvmod speed,congenic
R4397 T17782 T17779 amod congenic,panels
R4398 T17783 T17785 ccomp developed,provided
R4399 T17784 T17783 auxpass were,developed
R44 T624 T623 punct ", ",1
R440 T2935 T2936 poss whose,boundaries
R4400 T17786 T17785 punct ", ",provided
R4401 T17787 T17788 det the,first
R4402 T17788 T17785 nsubj first,provided
R4403 T17789 T17790 det a,isolation
R4404 T17790 T17785 dobj isolation,provided
R4405 T17791 T17790 amod comprehensive,isolation
R4406 T17792 T17790 prep of,isolation
R4407 T17793 T17794 det all,QTL
R4408 T17794 T17792 pobj QTL,of
R4409 T17795 T17794 compound MMU2,QTL
R441 T2936 T2937 dep boundaries,defined
R4410 T17796 T17794 prep between,QTL
R4411 T17797 T17798 det the,strains
R4412 T17798 T17796 pobj strains,between
R4413 T17799 T17798 nmod B6,strains
R4414 T17800 T17799 punct ", ",B6
R4415 T17801 T17799 conj HG,B6
R4416 T17802 T17801 cc and,HG
R4417 T17803 T17801 conj CAST,HG
R4418 T17804 T17785 cc and,provided
R4419 T17805 T17806 det the,second
R442 T2857 T2855 relcl is,one
R4420 T17806 T17807 nsubj second,targeted
R4421 T17807 T17785 conj targeted,provided
R4422 T17808 T17809 det all,QTL
R4423 T17809 T17807 dobj QTL,targeted
R4424 T17810 T17809 prep outside,QTL
R4425 T17811 T17810 prep of,outside
R4426 T17812 T17811 pobj MMU2,of
R4427 T17813 T17785 punct .,provided
R4428 T17815 T17816 det Each,strain
R4429 T17816 T17819 nsubj strain,exhibited
R443 T2937 T2932 relcl defined,strain
R4430 T17817 T17818 advmod successfully,characterized
R4431 T17818 T17816 amod characterized,strain
R4432 T17820 T17821 amod phenotypic,differences
R4433 T17821 T17819 dobj differences,exhibited
R4434 T17822 T17819 advcl relative,exhibited
R4435 T17823 T17822 prep to,relative
R4436 T17824 T17825 compound control,mice
R4437 T17825 T17823 pobj mice,to
R4438 T17826 T17819 punct .,exhibited
R4439 T17828 T17829 det These,strains
R444 T2858 T2859 advmod mono,oligogenic
R4440 T17829 T17830 nsubj strains,represent
R4441 T17831 T17832 amod important,resources
R4442 T17832 T17830 dobj resources,represent
R4443 T17833 T17830 cc and,represent
R4444 T17834 T17830 conj provide,represent
R4445 T17835 T17836 det the,resource
R4446 T17836 T17834 dobj resource,provide
R4447 T17837 T17836 amod genetic,resource
R4448 T17838 T17839 aux to,clone
R4449 T17839 T17836 advcl clone,resource
R445 T2938 T2937 auxpass are,defined
R4450 T17840 T17839 advmod positionally,clone
R4451 T17841 T17842 amod numerous,genes
R4452 T17842 T17839 dobj genes,clone
R4453 T17843 T17844 amod quantitative,trait
R4454 T18103 T18100 pobj variation,due
R4455 T17844 T17842 compound trait,genes
R4456 T18104 T18103 prep within,variation
R4457 T17845 T17830 punct .,represent
R4458 T18105 T18106 det each,region
R4459 T18106 T18104 pobj region,within
R446 T2939 T2937 agent by,defined
R4460 T17847 T17848 nummod One,criticism
R4461 T18107 T18106 compound donor,region
R4462 T18108 T18076 punct .,screened
R4463 T17848 T17849 nsubj criticism,is
R4464 T18110 T18111 mark Although,put
R4465 T18111 T18115 advcl put,confound
R4466 T17850 T17848 prep of,criticism
R4467 T18112 T18113 amod great,effort
R4468 T18113 T18111 nsubjpass effort,put
R4469 T18114 T18111 auxpass was,put
R447 T2940 T2941 amod genetic,markers
R4470 T17851 T17852 det the,approach
R4471 T18116 T18111 prt forth,put
R4472 T18117 T18118 aux to,eliminate
R4473 T17852 T17850 pobj approach,of
R4474 T18118 T18111 advcl eliminate,put
R4475 T18119 T18120 amod non-donor,region
R4476 T17853 T17854 npadvmod speed,congenic
R4477 T18120 T18121 nmod region,effects
R4478 T18121 T18118 dobj effects,eliminate
R4479 T18122 T18121 amod direct,effects
R448 T2859 T2857 acomp oligogenic,is
R4480 T17854 T17852 amod congenic,approach
R4481 T18123 T18121 amod genetic,effects
R4482 T18124 T18115 punct ", ",confound
R4483 T18125 T18126 amod other,factors
R4484 T17855 T17856 det the,potential
R4485 T18126 T18115 nsubj factors,confound
R4486 T17856 T17849 attr potential,is
R4487 T17857 T17858 mark for,reside
R4488 T17858 T17856 advcl reside,potential
R4489 T17859 T17858 nsubj QTL,reside
R449 T2941 T2939 pobj markers,by
R4490 T18127 T18128 amod such,as
R4491 T18128 T18126 prep as,factors
R4492 T18129 T18130 amod maternal,genotype
R4493 T18130 T18128 pobj genotype,as
R4494 T17860 T17858 aux to,reside
R4495 T18131 T18132 punct (,differed
R4496 T18132 T18130 parataxis differed,genotype
R4497 T18133 T18134 amod maternal,genotype
R4498 T17861 T17858 prep among,reside
R4499 T18134 T18132 nsubj genotype,differed
R45 T625 T623 conj 2,1
R450 T2942 T2927 punct ", ",introgressing
R4500 T17862 T17863 amod unwanted,alleles
R4501 T18135 T18134 prep for,genotype
R4502 T18136 T18137 det each,congenic
R4503 T18137 T18135 pobj congenic,for
R4504 T18138 T18134 cc versus,genotype
R4505 T18139 T18140 compound control,dams
R4506 T17863 T17861 pobj alleles,among
R4507 T18140 T18134 conj dams,genotype
R4508 T18141 T18132 punct ),differed
R4509 T18142 T18126 cc and,factors
R451 T2943 T2927 prep on,introgressing
R4510 T18143 T18144 amod environmental,effects
R4511 T18144 T18126 conj effects,factors
R4512 T18145 T18115 aux could,confound
R4513 T18146 T18147 poss our,results
R4514 T18147 T18115 dobj results,confound
R4515 T18148 T18115 punct .,confound
R4516 T17864 T17863 compound donor,alleles
R4517 T18150 T18151 amod Maternal,genotype
R4518 T18151 T18152 compound genotype,effects
R4519 T17865 T17866 neg not,eliminated
R452 T2860 T2859 punct -,oligogenic
R4520 T18152 T18153 nsubjpass effects,observed
R4521 T18154 T18152 prep on,effects
R4522 T17866 T17863 acl eliminated,alleles
R4523 T18155 T18154 pobj growth,on
R4524 T18156 T18155 cc and,growth
R4525 T17867 T17866 prep during,eliminated
R4526 T18157 T18155 conj obesity,growth
R4527 T18158 T18153 aux have,observed
R4528 T18159 T18153 auxpass been,observed
R4529 T17868 T17867 pobj backcrossing,during
R453 T2944 T2945 det the,background
R4530 T18160 T18153 prep in,observed
R4531 T18161 T18162 det a,number
R4532 T18162 T18160 pobj number,in
R4533 T17869 T17849 punct .,is
R4534 T18163 T18162 prep of,number
R4535 T18164 T18165 compound mouse,crosses
R4536 T17871 T17872 prep In,be
R4537 T18165 T18163 pobj crosses,of
R4538 T18166 T18167 punct [,8
R4539 T18167 T18153 parataxis 8,observed
R454 T2945 T2943 pobj background,on
R4540 T18168 T18167 punct ",",8
R4541 T17873 T17874 det this,case
R4542 T18169 T18167 appos 32,8
R4543 T18170 T18171 punct -,35
R4544 T18171 T18169 prep 35,32
R4545 T18172 T18167 punct ],8
R4546 T18173 T18153 cc and,observed
R4547 T18174 T18175 poss their,existence
R4548 T18175 T18176 nsubjpass existence,discounted
R4549 T17874 T17871 pobj case,In
R455 T2946 T2945 amod genetic,background
R4550 T18176 T18153 conj discounted,observed
R4551 T18177 T18175 prep in,existence
R4552 T18178 T18179 det the,cross
R4553 T17875 T17872 nsubj differences,be
R4554 T18179 T18177 pobj cross,in
R4555 T18180 T18179 amod current,cross
R4556 T18181 T18176 aux can,discounted
R4557 T17876 T17875 prep between,differences
R4558 T18182 T18176 neg not,discounted
R4559 T18183 T18176 auxpass be,discounted
R456 T2861 T2859 cc or,oligogenic
R4560 T18184 T18176 punct .,discounted
R4561 T17877 T17878 det the,strains
R4562 T18186 T18187 advmod However,provide
R4563 T17878 T17876 pobj strains,between
R4564 T18188 T18187 punct ", ",provide
R4565 T18189 T18190 poss our,congenics
R4566 T17879 T17878 amod congenic,strains
R4567 T18190 T18187 nsubj congenics,provide
R4568 T18191 T18192 det the,resource
R4569 T17880 T17879 cc and,congenic
R457 T2947 T2945 prep of,background
R4570 T18192 T18187 dobj resource,provide
R4571 T18193 T18192 amod ideal,resource
R4572 T18194 T18192 nmod foundation,resource
R4573 T17881 T17879 conj control,congenic
R4574 T18195 T18192 amod genomic,resource
R4575 T18196 T18197 aux to,test
R4576 T18197 T18192 advcl test,resource
R4577 T17882 T17872 aux would,be
R4578 T18198 T18197 prep for,test
R4579 T18199 T18200 det the,influence
R458 T2948 T2949 det a,strain
R4580 T18200 T18198 pobj influence,for
R4581 T17883 T17872 prep due,be
R4582 T18201 T18200 prep of,influence
R4583 T18202 T18201 pobj any,of
R4584 T18203 T18202 prep of,any
R4585 T17884 T17883 prep in,due
R4586 T18204 T18205 det these,effects
R4587 T18205 T18203 pobj effects,of
R4588 T17885 T17884 pobj part,in
R4589 T17886 T17885 cc or,part
R459 T2949 T2947 pobj strain,of
R4590 T18206 T18205 amod possible,effects
R4591 T18207 T18187 punct .,provide
R4592 T17887 T17885 conj whole,part
R4593 T18209 T18210 amod Future,experiments
R4594 T18210 T18213 nsubjpass experiments,designed
R4595 T18211 T18212 amod fine,mapping
R4596 T17888 T17883 pcomp to,due
R4597 T18212 T18210 compound mapping,experiments
R4598 T17889 T17890 det these,alleles
R4599 T17890 T17883 pobj alleles,due
R46 T626 T625 punct ", ",2
R460 T2862 T2837 punct .,are
R4600 T17891 T17890 amod contaminating,alleles
R4601 T17892 T17872 punct .,be
R4602 T17894 T17895 nsubj We,took
R4603 T18214 T18213 aux can,designed
R4604 T18215 T18213 auxpass be,designed
R4605 T18216 T18217 aux to,randomize
R4606 T17896 T17897 amod several,precautions
R4607 T18217 T18213 advcl randomize,designed
R4608 T18218 T18219 det the,influences
R4609 T17897 T17895 dobj precautions,took
R461 T2950 T2949 compound recipient,strain
R4610 T18219 T18217 dobj influences,randomize
R4611 T18220 T18219 prep of,influences
R4612 T18221 T18222 det any,alleles
R4613 T17898 T17899 aux to,reduce
R4614 T18222 T18220 pobj alleles,of
R4615 T18223 T18222 amod contaminating,alleles
R4616 T17899 T17895 advcl reduce,took
R4617 T18224 T18222 compound donor,alleles
R4618 T18225 T18222 cc and,alleles
R4619 T18226 T18227 amod environmental,differences
R462 T2951 T2927 prep via,introgressing
R4620 T17900 T17901 det the,probability
R4621 T18227 T18222 conj differences,alleles
R4622 T18228 T18217 punct ", ",randomize
R4623 T18229 T18230 advmod as,as
R4624 T17901 T17899 dobj probability,reduce
R4625 T18230 T18217 cc as,randomize
R4626 T18231 T18230 advmod well,as
R4627 T18232 T18217 conj test,randomize
R4628 T17902 T17901 prep of,probability
R4629 T18233 T18232 prep for,test
R463 T2864 T2865 nsubjpass This,accomplished
R4630 T18234 T18235 amod maternal,genotype
R4631 T17903 T17904 det this,occurrence
R4632 T18235 T18236 compound genotype,effects
R4633 T18236 T18233 pobj effects,for
R4634 T18237 T18213 punct .,designed
R4635 T17904 T17902 pobj occurrence,of
R4636 T18239 T18240 nsubj MMU2,is
R4637 T17905 T17895 punct .,took
R4638 T18241 T18242 det a,hotspot
R4639 T18242 T18240 attr hotspot,is
R464 T2952 T2953 nummod 10,backcrosses
R4640 T17907 T17908 advmod First,developed
R4641 T18243 T18242 prep for,hotspot
R4642 T18244 T18245 nmod growth,QTL
R4643 T18245 T18243 pobj QTL,for
R4644 T18246 T18244 cc and,growth
R4645 T17909 T17908 punct ", ",developed
R4646 T18247 T18244 conj obesity,growth
R4647 T18248 T18240 punct .,is
R4648 T18250 T18251 quantmod Over,30
R4649 T18251 T18252 nummod 30,QTL
R465 T2953 T2951 pobj backcrosses,via
R4650 T18252 T18253 nsubjpass QTL,identified
R4651 T17910 T17911 poss our,strains
R4652 T18254 T18253 aux have,identified
R4653 T18255 T18253 auxpass been,identified
R4654 T17911 T17908 nsubjpass strains,developed
R4655 T18256 T18253 prep in,identified
R4656 T18257 T18258 amod various,experiments
R4657 T18258 T18256 pobj experiments,in
R4658 T17912 T17911 compound control,strains
R4659 T18259 T18260 punct [,2
R466 T2954 T2955 punct [,4
R4660 T18260 T18253 parataxis 2,identified
R4661 T17913 T17908 auxpass were,developed
R4662 T18261 T18260 nummod 1,2
R4663 T18262 T18260 punct ",",2
R4664 T17914 T17908 prep from,developed
R4665 T18263 T18260 punct ],2
R4666 T18264 T18253 punct .,identified
R4667 T17915 T17914 pobj mice,from
R4668 T18266 T18267 amod Several,QTL
R4669 T18267 T18273 nsubjpass QTL,isolated
R467 T2955 T2927 parataxis 4,introgressing
R4670 T18268 T18269 advmod previously,reported
R4671 T17916 T17915 acl undergoing,mice
R4672 T18269 T18267 amod reported,QTL
R4673 T18270 T18269 cc or,reported
R4674 T18271 T18269 conj novel,reported
R4675 T17917 T17918 det the,selection
R4676 T18272 T18267 compound MMU2,QTL
R4677 T18274 T18273 aux have,isolated
R4678 T17918 T17916 dobj selection,undergoing
R4679 T18275 T18273 auxpass been,isolated
R468 T2956 T2955 punct ],4
R4680 T18276 T18273 cc and,isolated
R4681 T17919 T17918 amod same,selection
R4682 T18277 T18273 conj characterized,isolated
R4683 T18278 T18277 advcl using,characterized
R4684 T18279 T18280 amod congenic,strains
R4685 T17920 T17918 prep as,selection
R4686 T18280 T18278 dobj strains,using
R4687 T18281 T18282 punct [,7
R4688 T18282 T18277 parataxis 7,characterized
R4689 T17921 T17920 pobj all,as
R469 T2866 T2865 auxpass is,accomplished
R4690 T18283 T18282 punct ",",7
R4691 T18284 T18282 appos 9,7
R4692 T18285 T18286 punct -,11
R4693 T17922 T17921 prep of,all
R4694 T18286 T18284 prep 11,9
R4695 T18287 T18282 punct ",",7
R4696 T18288 T18282 appos 36,7
R4697 T17923 T17924 det the,congenics
R4698 T18289 T18282 punct ],7
R4699 T18290 T18273 punct .,isolated
R47 T627 T625 conj 5,2
R470 T2957 T2921 punct .,developed
R4700 T18292 T18293 poss Our,findings
R4701 T18293 T18294 nsubj findings,are
R4702 T17924 T17922 pobj congenics,of
R4703 T18295 T18296 neg no,different
R4704 T18296 T18294 acomp different,are
R4705 T17925 T17924 amod other,congenics
R4706 T18297 T18296 cc and,different
R4707 T18298 T18296 conj indicate,different
R4708 T18299 T18300 mark that,is
R4709 T17926 T17908 punct .,developed
R471 T2959 T2960 mark While,straightforward
R4710 T18300 T18298 ccomp is,indicate
R4711 T18301 T18300 nsubj MMU2,is
R4712 T17928 T17929 advmod Therefore,is
R4713 T18302 T18303 advmod highly,complex
R4714 T17930 T17929 punct ", ",is
R4715 T17931 T17929 nsubj it,is
R4716 T17932 T17929 acomp possible,is
R4717 T18303 T18300 acomp complex,is
R4718 T17933 T17934 mark that,shared
R4719 T18304 T18300 prep with,is
R472 T2960 T2962 advcl straightforward,is
R4720 T18305 T18304 pobj regards,with
R4721 T17934 T17929 ccomp shared,is
R4722 T18306 T18305 prep to,regards
R4723 T18307 T18308 nsubj genes,affecting
R4724 T18308 T18306 pcomp affecting,to
R4725 T17935 T17936 det any,QTL
R4726 T18309 T18308 dobj growth,affecting
R4727 T18310 T18309 cc and,growth
R4728 T18311 T18309 conj obesity,growth
R4729 T17936 T17934 nsubjpass QTL,shared
R473 T2867 T2865 prep by,accomplished
R4730 T17937 T17936 amod unwanted,QTL
R4731 T18312 T18294 punct .,are
R4732 T17938 T17936 cc or,QTL
R4733 T18314 T18315 det The,nature
R4734 T18315 T18317 nsubj nature,allowed
R4735 T17939 T17936 conj mutations,QTL
R4736 T18316 T18315 amod overlapping,nature
R4737 T17940 T17939 acl arising,mutations
R4738 T18318 T18315 prep of,nature
R4739 T18319 T18320 poss our,strains
R474 T2961 T2960 advmod technically,straightforward
R4740 T18320 T18318 pobj strains,of
R4741 T17941 T17940 prep during,arising
R4742 T18321 T18320 compound MMU2,strains
R4743 T18322 T18323 nsubj us,parse
R4744 T17942 T17943 amod congenic,construction
R4745 T18323 T18317 ccomp parse,allowed
R4746 T18324 T18323 aux to,parse
R4747 T17943 T17941 pobj construction,during
R4748 T18325 T18326 det the,chromosome
R4749 T18326 T18323 dobj chromosome,parse
R475 T2963 T2962 nsubj this,is
R4750 T18327 T18323 prep into,parse
R4751 T18328 T18329 nummod five,regions
R4752 T18329 T18327 pobj regions,into
R4753 T17944 T17934 auxpass are,shared
R4754 T18330 T18329 punct (,regions
R4755 T18331 T18332 nmod Regions,I
R4756 T18332 T18329 appos I,regions
R4757 T17945 T17934 prep between,shared
R4758 T18333 T18334 punct –,V
R4759 T18334 T18332 prep V,I
R476 T2868 T2867 pcomp eliminating,by
R4760 T18335 T18317 punct ),allowed
R4761 T18336 T18337 punct (,Figure
R4762 T17946 T17947 det all,strains
R4763 T18337 T18317 parataxis Figure,allowed
R4764 T18338 T18337 nummod 2,Figure
R4765 T17947 T17945 pobj strains,between
R4766 T17948 T17929 punct .,is
R4767 T17950 T17951 advmod More,importantly
R4768 T17951 T17952 advmod importantly,have
R4769 T17953 T17952 punct ", ",have
R477 T2964 T2965 det a,endeavor
R4770 T17954 T17952 nsubj we,have
R4771 T18339 T18337 punct ),Figure
R4772 T17955 T17952 dobj knowledge,have
R4773 T18340 T18317 punct .,allowed
R4774 T18342 T18343 det The,data
R4775 T18343 T18344 nsubj data,support
R4776 T18345 T18346 det the,presence
R4777 T18346 T18344 dobj presence,support
R4778 T18347 T18346 prep of,presence
R4779 T18348 T18349 advmod at,one
R478 T2965 T2962 attr endeavor,is
R4780 T17956 T17955 prep of,knowledge
R4781 T18349 T18351 nummod one,QTL
R4782 T18350 T18349 advmod least,one
R4783 T18351 T18347 pobj QTL,of
R4784 T18352 T18346 prep in,presence
R4785 T17957 T17958 det all,QTL
R4786 T18353 T18352 pobj each,in
R4787 T18354 T18353 prep of,each
R4788 T18355 T18356 det the,regions
R4789 T17958 T17956 pobj QTL,of
R479 T2966 T2967 npadvmod time,consuming
R4790 T18356 T18354 pobj regions,of
R4791 T18357 T18356 nummod five,regions
R4792 T17959 T17958 amod large,QTL
R4793 T18358 T18359 punct (,Figure
R4794 T18359 T18344 parataxis Figure,support
R4795 T18360 T18359 nummod 2,Figure
R4796 T17960 T17961 advmod previously,detected
R4797 T18361 T18359 punct ),Figure
R4798 T18362 T18344 punct .,support
R4799 T17961 T17958 amod detected,QTL
R48 T628 T627 punct ", ",5
R480 T2869 T2868 xcomp segregating,eliminating
R4800 T18364 T18365 nsubj Each,impact
R4801 T17962 T17958 nmod growth,QTL
R4802 T18366 T18364 prep of,Each
R4803 T18367 T18368 det the,five
R4804 T18368 T18366 pobj five,of
R4805 T18369 T18365 advmod pleiotropically,impact
R4806 T18370 T18371 preconj both,growth
R4807 T17963 T17962 cc and,growth
R4808 T18371 T18365 dobj growth,impact
R4809 T18372 T18371 cc and,growth
R481 T2967 T2965 amod consuming,endeavor
R4810 T18373 T18371 conj obesity,growth
R4811 T17964 T17962 conj obesity,growth
R4812 T18374 T18365 punct ", ",impact
R4813 T18375 T18376 mark although,to
R4814 T17965 T17958 prep in,QTL
R4815 T18376 T18365 advcl to,impact
R4816 T18377 T18378 amod varying,degrees
R4817 T18378 T18376 pobj degrees,to
R4818 T17966 T17967 det the,cross
R4819 T18379 T18365 punct .,impact
R482 T2968 T2965 acl taking,endeavor
R4820 T17967 T17965 pobj cross,in
R4821 T18381 T18382 prep In,adds
R4822 T18383 T18381 pobj addition,In
R4823 T17968 T17967 amod current,cross
R4824 T18384 T18383 prep to,addition
R4825 T18385 T18386 det the,number
R4826 T17969 T17970 punct [,24
R4827 T18386 T18384 pobj number,to
R4828 T18387 T18386 amod large,number
R4829 T18388 T18386 prep of,number
R483 T2969 T2970 quantmod over,three
R4830 T17970 T17952 parataxis 24,have
R4831 T18389 T18390 compound MMU2,QTL
R4832 T18390 T18388 pobj QTL,of
R4833 T18391 T18382 punct ", ",adds
R4834 T17971 T17970 punct ],24
R4835 T17972 T17952 punct .,have
R4836 T17974 T17975 advcl Using,increased
R4837 T17976 T17977 det this,information
R4838 T18392 T18393 det the,presence
R4839 T17977 T17974 dobj information,Using
R484 T2870 T2871 amod genetic,variation
R4840 T18393 T18382 nsubj presence,adds
R4841 T18394 T18393 prep of,presence
R4842 T17978 T17975 nsubj we,increased
R4843 T18395 T18394 pobj hg,of
R4844 T18396 T18382 dobj complexity,adds
R4845 T17979 T17980 det the,density
R4846 T18397 T18382 prep by,adds
R4847 T18398 T18397 preconj either,by
R4848 T18399 T18397 conj eliciting,by
R4849 T17980 T17975 dobj density,increased
R485 T2970 T2971 nummod three,years
R4850 T18400 T18399 dobj interactions,eliciting
R4851 T18401 T18400 prep with,interactions
R4852 T17981 T17980 prep of,density
R4853 T18402 T18403 det the,QTL
R4854 T18403 T18401 pobj QTL,with
R4855 T18404 T18403 amod same,QTL
R4856 T18405 T18397 cc or,by
R4857 T18406 T18397 conj by,by
R4858 T17982 T17981 pobj markers,of
R4859 T18407 T18406 pcomp inducing,by
R486 T2971 T2968 dobj years,taking
R4860 T18408 T18409 det the,expression
R4861 T18409 T18407 dobj expression,inducing
R4862 T17983 T17980 prep in,density
R4863 T18410 T18409 prep of,expression
R4864 T18411 T18412 amod novel,QTL
R4865 T18412 T18410 pobj QTL,of
R4866 T17984 T17985 det each,region
R4867 T18413 T18382 punct .,adds
R4868 T17985 T17983 pobj region,in
R4869 T18415 T18416 det The,region
R487 T2972 T2973 aux to,construct
R4870 T18416 T18419 nsubj region,contains
R4871 T18417 T18416 nmod 2P,region
R4872 T17986 T17985 compound QTL,region
R4873 T17987 T17988 punct (,Table
R4874 T18418 T18416 amod unique,region
R4875 T17988 T17975 parataxis Table,increased
R4876 T18420 T18416 punct (,region
R4877 T17989 T17990 nmod MMU,1
R4878 T18421 T18416 appos Region,region
R4879 T18422 T18421 nummod I,Region
R488 T2973 T2968 advcl construct,taking
R4880 T17990 T17988 dep 1,Table
R4881 T18423 T18419 punct ),contains
R4882 T18424 T18425 det an,modifier
R4883 T18425 T18419 dobj modifier,contains
R4884 T17991 T17990 punct ", ",1
R4885 T18426 T18425 compound hg,modifier
R4886 T18427 T18425 prep with,modifier
R4887 T17992 T17990 conj 2,1
R4888 T18428 T18429 amod large,effects
R4889 T18429 T18427 pobj effects,with
R489 T2974 T2975 det a,strain
R4890 T17993 T17992 punct ", ",2
R4891 T18430 T18429 prep on,effects
R4892 T18431 T18430 pobj growth,on
R4893 T17994 T17992 conj 5,2
R4894 T18432 T18429 cc and,effects
R4895 T18433 T18434 amod smaller,effects
R4896 T17995 T17994 punct ", ",5
R4897 T18434 T18429 conj effects,effects
R4898 T18435 T18434 prep on,effects
R4899 T18436 T18435 pobj obesity,on
R49 T629 T627 conj 8,5
R490 T2975 T2973 dobj strain,construct
R4900 T17996 T17994 conj 8,5
R4901 T18437 T18438 punct (,Table
R4902 T18438 T18419 parataxis Table,contains
R4903 T18439 T18438 nummod 3,Table
R4904 T17997 T17996 punct ", ",8
R4905 T18440 T18438 punct ),Table
R4906 T18441 T18419 punct .,contains
R4907 T18443 T18444 prep In,affect
R4908 T17998 T17996 conj 9,8
R4909 T18445 T18443 pobj contrast,In
R491 T2871 T2869 dobj variation,segregating
R4910 T18446 T18444 punct ", ",affect
R4911 T18447 T18444 nsubj interactions,affect
R4912 T17999 T17998 punct ", ",9
R4913 T18448 T18447 prep between,interactions
R4914 T18449 T18450 compound 2PM,2M
R4915 T18450 T18452 compound 2M,QTL
R4916 T18000 T17998 conj 11,9
R4917 T18451 T18450 punct /,2M
R4918 T18452 T18448 pobj QTL,between
R4919 T18001 T18000 cc and,11
R492 T2976 T2975 amod single,strain
R4920 T18453 T18452 cc and,QTL
R4921 T18454 T18452 conj hg,QTL
R4922 T18455 T18444 advmod primarily,affect
R4923 T18002 T18000 conj 17,11
R4924 T18456 T18457 compound fat,deposition
R4925 T18457 T18444 dobj deposition,affect
R4926 T18003 T17988 punct ;,Table
R4927 T18458 T18459 punct (,Table
R4928 T18459 T18444 parataxis Table,affect
R4929 T18460 T18459 nummod 3,Table
R493 T2977 T2962 punct .,is
R4930 T18004 T17988 nummod 1,Table
R4931 T18461 T18459 punct ),Table
R4932 T18462 T18444 punct .,affect
R4933 T18005 T17988 cc and,Table
R4934 T18464 T18465 mark As,illustrated
R4935 T18465 T18466 advcl illustrated,exhibits
R4936 T18006 T18007 amod Additional,File
R4937 T18467 T18465 prep in,illustrated
R4938 T18007 T17988 conj File,Table
R4939 T18468 T18467 pobj Figure,in
R494 T2872 T2869 prep outside,segregating
R4940 T18008 T18007 nummod 1,File
R4941 T18009 T17988 punct ),Table
R4942 T18010 T17975 punct ", ",increased
R4943 T18011 T17975 advcl ensuring,increased
R4944 T18012 T18013 det the,absence
R4945 T18469 T18468 nummod 4,Figure
R4946 T18470 T18471 det the,region
R4947 T18471 T18466 nsubj region,exhibits
R4948 T18013 T18011 dobj absence,ensuring
R4949 T18472 T18471 compound 2M,region
R495 T2979 T2980 det The,approach
R4950 T18473 T18471 compound donor,region
R4951 T18474 T18475 amod strong,effects
R4952 T18014 T18013 prep of,absence
R4953 T18475 T18466 dobj effects,exhibits
R4954 T18476 T18475 compound sex,effects
R4955 T18015 T18016 compound CAST,alleles
R4956 T18477 T18475 prep on,effects
R4957 T18478 T18479 det the,rate
R4958 T18016 T18014 pobj alleles,of
R4959 T18017 T18013 prep at,absence
R496 T2980 T2983 nsubj approach,is
R4960 T18018 T18017 pobj each,at
R4961 T18479 T18477 pobj rate,on
R4962 T18019 T18018 prep of,each
R4963 T18480 T18479 prep of,rate
R4964 T18481 T18482 compound lipid,storage
R4965 T18482 T18480 pobj storage,of
R4966 T18020 T18021 det these,QTL
R4967 T18483 T18466 punct ", ",exhibits
R4968 T18484 T18466 advcl dependent,exhibits
R4969 T18485 T18484 prep on,dependent
R497 T2873 T2874 det the,locus
R4970 T18021 T18019 pobj QTL,of
R4971 T18486 T18485 pobj background,on
R4972 T18487 T18466 punct .,exhibits
R4973 T18022 T17975 punct .,increased
R4974 T18489 T18490 prep In,have
R4975 T18024 T18025 det This,approach
R4976 T18491 T18492 compound control,mice
R4977 T18492 T18489 pobj mice,In
R4978 T18493 T18490 punct ", ",have
R4979 T18025 T18026 nsubjpass approach,used
R498 T2981 T2982 npadvmod speed,congenic
R4980 T18494 T18495 compound HGC,females
R4981 T18495 T18490 nsubj females,have
R4982 T18027 T18025 punct ", ",approach
R4983 T18496 T18497 det a,AI
R4984 T18497 T18490 dobj AI,have
R4985 T18498 T18497 amod higher,AI
R4986 T18499 T18497 prep than,AI
R4987 T18500 T18499 pobj males,than
R4988 T18028 T18025 acl termed,approach
R4989 T18501 T18490 punct ", ",have
R499 T2982 T2980 amod congenic,approach
R4990 T18502 T18503 mark while,seen
R4991 T18029 T18028 punct """",termed
R4992 T18503 T18490 advcl seen,have
R4993 T18504 T18505 det the,opposite
R4994 T18505 T18503 nsubjpass opposite,seen
R4995 T18030 T18031 compound QTL,Marker
R4996 T18506 T18503 auxpass is,seen
R4997 T18507 T18503 prep in,seen
R4998 T18031 T18033 npadvmod Marker,Assisted
R4999 T18508 T18509 compound B6C,mice
R5 T580 T578 pobj QTL,of
R50 T630 T629 punct ", ",8
R500 T2984 T2985 det an,alternative
R5000 T18509 T18507 pobj mice,in
R5001 T18510 T18490 punct .,have
R5002 T18032 T18031 punct -,Marker
R5003 T18512 T18513 advmod Interestingly,abolished
R5004 T18033 T18035 amod Assisted,Selection
R5005 T18514 T18513 punct ", ",abolished
R5006 T18515 T18516 det the,QTL
R5007 T18034 T18033 punct -,Assisted
R5008 T18516 T18513 nsubj QTL,abolished
R5009 T18517 T18516 compound 2M,QTL
R501 T2874 T2872 pobj locus,outside
R5010 T18518 T18519 compound hg,modifier
R5011 T18519 T18516 compound modifier,QTL
R5012 T18035 T18028 oprd Selection,termed
R5013 T18520 T18521 det the,dimorphism
R5014 T18521 T18513 dobj dimorphism,abolished
R5015 T18522 T18523 npadvmod hg,induced
R5016 T18523 T18521 amod induced,dimorphism
R5017 T18036 T18035 compound Counter,Selection
R5018 T18037 T18035 punct """",Selection
R5019 T18524 T18521 amod sexual,dimorphism
R502 T2985 T2983 attr alternative,is
R5020 T18038 T18035 cc or,Selection
R5021 T18525 T18521 prep in,dimorphism
R5022 T18526 T18525 pobj adiposity,in
R5023 T18039 T18035 conj QMACS,Selection
R5024 T18527 T18528 punct (,Figure
R5025 T18528 T18513 parataxis Figure,abolished
R5026 T18040 T18026 punct ", ",used
R5027 T18529 T18528 nummod 4,Figure
R5028 T18530 T18528 punct ),Figure
R5029 T18531 T18513 punct .,abolished
R503 T2986 T2985 prep to,alternative
R5030 T18533 T18534 mark Although,provide
R5031 T18041 T18026 aux has,used
R5032 T18534 T18537 advcl provide,noted
R5033 T18535 T18536 det these,results
R5034 T18042 T18026 auxpass been,used
R5035 T18536 T18534 nsubj results,provide
R5036 T18043 T18026 advmod previously,used
R5037 T18538 T18534 dobj insight,provide
R5038 T18539 T18538 prep into,insight
R5039 T18540 T18541 det the,nature
R504 T2875 T2874 prep of,locus
R5040 T18044 T18045 aux to,characterize
R5041 T18541 T18539 pobj nature,into
R5042 T18542 T18541 prep of,nature
R5043 T18045 T18026 advcl characterize,used
R5044 T18543 T18544 compound hg,modifier
R5045 T18544 T18545 compound modifier,QTL
R5046 T18046 T18045 dobj QTL,characterize
R5047 T18545 T18542 pobj QTL,of
R5048 T18546 T18537 punct ", ",noted
R5049 T18547 T18537 nsubjpass it,noted
R505 T2987 T2988 det this,process
R5050 T18047 T18045 prep for,characterize
R5051 T18548 T18537 aux should,noted
R5052 T18549 T18537 auxpass be,noted
R5053 T18048 T18049 amod hypnotic,sensitivity
R5054 T18550 T18537 punct ", ",noted
R5055 T18551 T18552 mark that,is
R5056 T18552 T18537 ccomp is,noted
R5057 T18049 T18047 pobj sensitivity,for
R5058 T18553 T18554 det the,number
R5059 T18554 T18552 nsubj number,is
R506 T2988 T2986 pobj process,to
R5060 T18555 T18554 amod actual,number
R5061 T18556 T18554 cc and,number
R5062 T18557 T18558 amod precise,location
R5063 T18558 T18554 conj location,number
R5064 T18050 T18049 prep to,sensitivity
R5065 T18559 T18554 prep of,number
R5066 T18560 T18559 pobj loci,of
R5067 T18561 T18552 advmod still,is
R5068 T18051 T18050 pobj ethanol,to
R5069 T18562 T18552 acomp unclear,is
R507 T2989 T2988 amod lengthy,process
R5070 T18563 T18537 punct .,noted
R5071 T18052 T18053 punct [,31
R5072 T18565 T18566 prep In,captured
R5073 T18053 T18026 parataxis 31,used
R5074 T18567 T18565 pobj addition,In
R5075 T18054 T18053 punct ],31
R5076 T18055 T18026 punct .,used
R5077 T18057 T18058 prep In,typed
R5078 T18059 T18060 det that,study
R5079 T18060 T18057 pobj study,In
R508 T2876 T2875 pobj interest,of
R5080 T18568 T18567 prep to,addition
R5081 T18061 T18058 punct ", ",typed
R5082 T18569 T18568 pobj MMU2,to
R5083 T18570 T18566 punct ", ",captured
R5084 T18062 T18063 advmod only,markers
R5085 T18571 T18572 nummod three,congenics
R5086 T18572 T18566 nsubj congenics,captured
R5087 T18573 T18572 amod other,congenics
R5088 T18063 T18058 nsubjpass markers,typed
R5089 T18574 T18572 punct (,congenics
R509 T2990 T2983 cc and,is
R5090 T18575 T18572 appos HG9,congenics
R5091 T18064 T18063 acl flanking,markers
R5092 T18576 T18575 punct ", ",HG9
R5093 T18577 T18575 conj HG11,HG9
R5094 T18578 T18577 cc and,HG11
R5095 T18065 T18064 dobj QTL,flanking
R5096 T18579 T18577 conj HG17,HG11
R5097 T18580 T18566 punct ),captured
R5098 T18581 T18582 compound hg,modifier
R5099 T18066 T18058 auxpass were,typed
R51 T631 T629 conj 9,8
R510 T2991 T2992 aux can,reduce
R5100 T18582 T18583 compound modifier,QTL
R5101 T18583 T18566 dobj QTL,captured
R5102 T18584 T18566 punct .,captured
R5103 T18067 T18058 punct ", ",typed
R5104 T18586 T18587 prep In,are
R5105 T18068 T18069 cc not,markers
R5106 T18588 T18589 amod classical,terms
R5107 T18589 T18586 pobj terms,In
R5108 T18069 T18058 dep markers,typed
R5109 T18590 T18587 punct ", ",are
R511 T2992 T2983 conj reduce,is
R5110 T18591 T18587 nsubj they,are
R5111 T18070 T18071 npadvmod genome,wide
R5112 T18592 T18587 attr QTL,are
R5113 T18593 T18594 dep which,modify
R5114 T18594 T18592 relcl modify,QTL
R5115 T18595 T18596 det the,expressivity
R5116 T18596 T18594 dobj expressivity,modify
R5117 T18071 T18069 amod wide,markers
R5118 T18597 T18596 prep of,expressivity
R5119 T18598 T18597 pobj growth,of
R512 T2993 T2994 det the,number
R5120 T18599 T18598 cc and,growth
R5121 T18072 T18071 punct -,wide
R5122 T18600 T18598 conj obesity,growth
R5123 T18601 T18596 prep in,expressivity
R5124 T18073 T18058 punct .,typed
R5125 T18602 T18603 compound HG,mice
R5126 T18603 T18601 pobj mice,in
R5127 T18604 T18605 punct [,18
R5128 T18075 T18076 prep In,screened
R5129 T18605 T18587 parataxis 18,are
R513 T2877 T2868 cc and,eliminating
R5130 T18606 T18605 punct ],18
R5131 T18607 T18587 punct .,are
R5132 T18077 T18075 pobj contrast,In
R5133 T18609 T18610 det These,QTL
R5134 T18610 T18611 nsubj QTL,are
R5135 T18078 T18076 punct ", ",screened
R5136 T18612 T18611 acomp novel,are
R5137 T18613 T18614 mark since,represent
R5138 T18614 T18611 advcl represent,are
R5139 T18079 T18080 nsubj we,selected
R514 T2994 T2992 dobj number,reduce
R5140 T18615 T18614 nsubj they,represent
R5141 T18616 T18614 dobj epistasis,represent
R5142 T18080 T18076 ccomp selected,screened
R5143 T18617 T18616 prep between,epistasis
R5144 T18618 T18617 pobj hg,between
R5145 T18619 T18618 cc and,hg
R5146 T18081 T18080 preconj not,selected
R5147 T18620 T18621 det the,gene
R5148 T18621 T18618 conj gene,hg
R5149 T18622 T18621 compound modifier,gene
R515 T2995 T2994 prep of,number
R5150 T18082 T18081 advmod only,not
R5151 T18623 T18611 punct .,are
R5152 T18083 T18080 conj against,selected
R5153 T18625 T18626 compound QTL,hg
R5154 T18626 T18628 compound hg,epistasis
R5155 T18627 T18626 punct -,hg
R5156 T18084 T18085 amod known,QTL
R5157 T18628 T18629 nsubj epistasis,implies
R5158 T18085 T18083 pobj QTL,against
R5159 T18086 T18076 punct ", ",screened
R516 T2878 T2868 conj reducing,eliminating
R5160 T18630 T18631 mark that,are
R5161 T18631 T18629 ccomp are,implies
R5162 T18087 T18076 nsubj we,screened
R5163 T18632 T18631 nsubj Socs2,are
R5164 T18633 T18632 cc and,Socs2
R5165 T18634 T18635 det the,modifiers
R5166 T18635 T18632 conj modifiers,Socs2
R5167 T18636 T18635 compound hg,modifiers
R5168 T18088 T18076 advmod also,screened
R5169 T18637 T18631 prep in,are
R517 T2996 T2997 amod required,backcrosses
R5170 T18638 T18639 det the,pathway
R5171 T18639 T18637 pobj pathway,in
R5172 T18089 T18076 prep for,screened
R5173 T18640 T18639 amod same,pathway
R5174 T18641 T18639 amod biological,pathway
R5175 T18090 T18091 npadvmod genome,wide
R5176 T18642 T18629 punct .,implies
R5177 T18091 T18092 amod wide,heterozygosity
R5178 T18644 T18645 advmod Therefore,are
R5179 T18646 T18645 punct ", ",are
R518 T2997 T2995 pobj backcrosses,of
R5180 T18092 T18089 pobj heterozygosity,for
R5181 T18647 T18648 det these,QTL
R5182 T18648 T18645 nsubj QTL,are
R5183 T18093 T18076 advcl increasing,screened
R5184 T18649 T18645 advmod likely,are
R5185 T18650 T18645 prep due,are
R5186 T18651 T18650 pcomp to,due
R5187 T18094 T18095 det the,probability
R5188 T18652 T18650 pobj polymorphism,due
R5189 T18653 T18652 prep in,polymorphism
R519 T2998 T2992 prep from,reduce
R5190 T18654 T18653 pobj genes,in
R5191 T18095 T18093 dobj probability,increasing
R5192 T18655 T18654 acl interacting,genes
R5193 T18656 T18655 prep with,interacting
R5194 T18096 T18097 mark that,are
R5195 T18097 T18095 acl are,probability
R5196 T18098 T18097 nsubj effects,are
R5197 T18099 T18098 acl observed,effects
R5198 T18657 T18656 pobj Gh,with
R5199 T18100 T18097 prep due,are
R52 T632 T631 punct ", ",9
R520 T2879 T2880 det the,variation
R5200 T18658 T18655 punct ", ",interacting
R5201 T18659 T18655 conj responsive,interacting
R5202 T18660 T18659 prep to,responsive
R5203 T18101 T18100 pcomp to,due
R5204 T18661 T18660 pobj Gh,to
R5205 T18662 T18659 cc or,responsive
R5206 T18102 T18103 amod genetic,variation
R5207 T18663 T18664 dep which,modulate
R5208 T18664 T18659 conj modulate,responsive
R5209 T18665 T18664 prep in,modulate
R521 T2999 T2998 pobj 10,from
R5210 T18836 T18837 prep In,is
R5211 T18666 T18667 det some,way
R5212 T18667 T18665 pobj way,in
R5213 T18668 T18669 compound Gh,function
R5214 T18669 T18664 dobj function,modulate
R5215 T18670 T18645 punct .,are
R5216 T18672 T18673 det This,information
R5217 T18673 T18674 nsubj information,aid
R5218 T18675 T18674 aux will,aid
R5219 T18676 T18674 advmod significantly,aid
R522 T3000 T2992 prep to,reduce
R5220 T18677 T18678 compound QTL,cloning
R5221 T18678 T18674 dobj cloning,aid
R5222 T18679 T18674 prep by,aid
R5223 T18680 T18679 pcomp providing,by
R5224 T18681 T18682 det another,filter
R5225 T18682 T18680 dobj filter,providing
R5226 T18683 T18684 aux to,screen
R5227 T18684 T18682 advcl screen,filter
R5228 T18685 T18684 dobj candidates,screen
R5229 T18686 T18674 punct .,aid
R523 T3001 T3000 pobj five,to
R5230 T18688 T18689 amod Cloning,QTL
R5231 T18689 T18691 nsubj QTL,has
R5232 T18690 T18689 det these,QTL
R5233 T18692 T18693 amod major,implications
R5234 T18693 T18691 dobj implications,has
R5235 T18694 T18695 aux to,improve
R5236 T18695 T18693 advcl improve,implications
R5237 T18696 T18697 poss our,understanding
R5238 T18838 T18836 pobj contrast,In
R5239 T18697 T18695 dobj understanding,improve
R524 T2880 T2878 dobj variation,reducing
R5240 T18698 T18697 prep of,understanding
R5241 T18699 T18698 pobj Gh,of
R5242 T18700 T18699 cc and,Gh
R5243 T18701 T18702 poss its,regulation
R5244 T18702 T18699 conj regulation,Gh
R5245 T18839 T18837 punct ", ",is
R5246 T18703 T18702 prep of,regulation
R5247 T18704 T18703 pobj growth,of
R5248 T18840 T18841 det the,strain
R5249 T18705 T18704 cc and,growth
R525 T3002 T3003 punct [,6
R5250 T18706 T18704 conj adiposity,growth
R5251 T18707 T18695 cc and,improve
R5252 T18841 T18837 nsubj strain,is
R5253 T18708 T18695 conj in,improve
R5254 T18709 T18710 det the,administration
R5255 T18842 T18841 compound HG9,strain
R5256 T18710 T18708 pobj administration,in
R5257 T18711 T18710 prep of,administration
R5258 T18712 T18713 amod human,Gh
R5259 T18843 T18844 det an,model
R526 T3003 T2992 parataxis 6,reduce
R5260 T18713 T18714 compound Gh,therapeutics
R5261 T18714 T18711 pobj therapeutics,of
R5262 T18715 T18691 punct .,has
R5263 T18844 T18837 attr model,is
R5264 T18717 T18718 compound HG1,mice
R5265 T18845 T18846 amod obese,mouse
R5266 T18718 T18719 nsubj mice,displayed
R5267 T18720 T18719 dobj differences,displayed
R5268 T18846 T18844 compound mouse,model
R5269 T18721 T18722 advmod only,in
R527 T3004 T3003 nummod 5,6
R5270 T18722 T18720 prep in,differences
R5271 T18723 T18724 compound growth,traits
R5272 T18724 T18722 pobj traits,in
R5273 T18725 T18719 punct .,displayed
R5274 T18847 T18837 punct .,is
R5275 T18727 T18728 advmod Originally,had
R5276 T18849 T18850 det The,strain
R5277 T18729 T18728 punct ", ",had
R5278 T18730 T18728 nsubj Q1Ucd1,had
R5279 T18731 T18732 amod small,effects
R528 T2881 T2880 amod environmental,variation
R5280 T18732 T18728 dobj effects,had
R5281 T18850 T18851 nsubj strain,is
R5282 T18733 T18728 cc and,had
R5283 T18734 T18735 det these,results
R5284 T18852 T18853 advmod quite,novel
R5285 T18735 T18736 nsubj results,illustrate
R5286 T18853 T18851 acomp novel,is
R5287 T18736 T18728 conj illustrate,had
R5288 T18854 T18851 prep for,is
R5289 T18737 T18738 det the,power
R529 T3005 T3003 punct ",",6
R5290 T18738 T18736 dobj power,illustrate
R5291 T18739 T18738 prep of,power
R5292 T18740 T18741 amod congenic,strain
R5293 T18855 T18856 nummod two,reasons
R5294 T18856 T18854 pobj reasons,for
R5295 T18857 T18851 punct .,is
R5296 T18741 T18742 compound strain,analysis
R5297 T18859 T18860 advmod First,was
R5298 T18742 T18739 pobj analysis,of
R5299 T18743 T18744 aux to,isolate
R53 T633 T631 conj 11,9
R530 T3006 T3003 punct ],6
R5300 T18861 T18860 punct ", ",was
R5301 T18744 T18738 acl isolate,power
R5302 T18745 T18746 amod small,effect
R5303 T18862 T18863 det the,size
R5304 T18863 T18865 nsubj size,is
R5305 T18864 T18863 compound effect,size
R5306 T18865 T18860 ccomp is,was
R5307 T18746 T18747 compound effect,QTL
R5308 T18866 T18865 acomp large,is
R5309 T18747 T18744 dobj QTL,isolate
R531 T3007 T2983 punct .,is
R5310 T18867 T18860 punct ;,was
R5311 T18748 T18736 punct ", ",illustrate
R5312 T18749 T18750 mark although,is
R5313 T18750 T18736 advcl is,illustrate
R5314 T18868 T18860 nsubj AI,was
R5315 T18751 T18750 nsubj it,is
R5316 T18752 T18750 acomp likely,is
R5317 T18869 T18870 nummod 57,%
R5318 T18753 T18754 det this,QTL
R5319 T18754 T18755 nsubj QTL,represents
R532 T2882 T2880 acl influencing,variation
R5320 T18755 T18752 advcl represents,likely
R5321 T18756 T18757 det the,boundary
R5322 T18757 T18755 dobj boundary,represents
R5323 T18870 T18871 npadvmod %,higher
R5324 T18758 T18757 amod lower,boundary
R5325 T18759 T18757 prep of,boundary
R5326 T18760 T18759 pobj detection,of
R5327 T18871 T18860 acomp higher,was
R5328 T18761 T18757 acl using,boundary
R5329 T18762 T18763 advmod only,30
R533 T2883 T2884 det a,trait
R5330 T18872 T18871 prep in,higher
R5331 T18763 T18766 nummod 30,mice
R5332 T18764 T18763 quantmod 20,30
R5333 T18765 T18763 punct –,30
R5334 T18873 T18874 compound HG9,females
R5335 T18766 T18761 dobj mice,using
R5336 T18767 T18766 amod congenic,mice
R5337 T18768 T18736 punct .,illustrate
R5338 T18874 T18872 pobj females,in
R5339 T18770 T18771 det The,genes
R534 T2884 T2882 dobj trait,influencing
R5340 T18771 T18775 nsubj genes,are
R5341 T18875 T18871 cc and,higher
R5342 T18772 T18773 advmod most,notable
R5343 T18773 T18771 amod notable,genes
R5344 T18774 T18771 compound candidate,genes
R5345 T18876 T18877 nummod 30,%
R5346 T18776 T18771 acl located,genes
R5347 T18877 T18878 npadvmod %,higher
R5348 T18777 T18776 prep within,located
R5349 T18778 T18779 det the,interval
R535 T3009 T3010 det This,strategy
R5350 T18878 T18871 conj higher,higher
R5351 T18779 T18777 pobj interval,within
R5352 T18780 T18779 compound HG1,interval
R5353 T18879 T18878 prep in,higher
R5354 T18781 T18782 det the,transducer
R5355 T18782 T18775 attr transducer,are
R5356 T18783 T18782 compound signal,transducer
R5357 T18880 T18879 pobj males,in
R5358 T18784 T18782 cc and,transducer
R5359 T18785 T18782 conj activator,transducer
R536 T2885 T2878 prep by,reducing
R5360 T18881 T18860 punct .,was
R5361 T18786 T18785 prep of,activator
R5362 T18787 T18786 pobj transcription,of
R5363 T18788 T18787 nummod 1,transcription
R5364 T18883 T18884 advmod Secondly,is
R5365 T18789 T18787 punct (,transcription
R5366 T18790 T18787 appos Stat1,transcription
R5367 T18791 T18787 punct ),transcription
R5368 T18885 T18884 punct ", ",is
R5369 T18792 T18787 cc and,transcription
R537 T3010 T3011 nsubj strategy,uses
R5370 T18793 T18787 conj Stat4,transcription
R5371 T18794 T18775 punct .,are
R5372 T18886 T18884 nsubj it,is
R5373 T18796 T18797 nsubj Two,had
R5374 T18798 T18796 prep of,Two
R5375 T18799 T18800 det the,congenics
R5376 T18800 T18798 pobj congenics,of
R5377 T18887 T18884 acomp dependent,is
R5378 T18801 T18802 amod major,alterations
R5379 T18802 T18797 dative alterations,had
R538 T3012 T3013 npadvmod marker,assisted
R5380 T18888 T18887 prep on,dependent
R5381 T18803 T18802 prep in,alterations
R5382 T18804 T18805 det the,deposition
R5383 T18805 T18803 pobj deposition,in
R5384 T18889 T18888 pobj hg,on
R5385 T18806 T18805 prep of,deposition
R5386 T18807 T18808 compound adipose,tissue
R5387 T18808 T18806 pobj tissue,of
R5388 T18890 T18884 prep for,is
R5389 T18809 T18797 punct ", ",had
R539 T3013 T3015 amod assisted,selection
R5390 T18810 T18797 dobj HG8,had
R5391 T18811 T18810 cc and,HG8
R5392 T18891 T18892 poss its,expression
R5393 T18812 T18810 conj HG9,HG8
R5394 T18813 T18797 punct .,had
R5395 T18892 T18890 pobj expression,for
R5396 T18815 T18816 det The,region
R5397 T18893 T18884 punct .,is
R5398 T18816 T18819 nsubj region,promotes
R5399 T18817 T18816 compound HG8,region
R54 T634 T633 cc and,11
R540 T3014 T3013 punct -,assisted
R5400 T18895 T18896 det The,strain
R5401 T18818 T18816 compound donor,region
R5402 T18820 T18819 dobj leanness,promotes
R5403 T18821 T18819 punct .,promotes
R5404 T18896 T18898 nsubj strain,represents
R5405 T18823 T18824 amod Congenic,females
R5406 T18897 T18896 compound HG9,strain
R5407 T18824 T18825 nsubj females,displayed
R5408 T18826 T18827 det a,reduction
R5409 T18899 T18900 det a,model
R541 T3015 T3011 dobj selection,uses
R5410 T18827 T18825 dobj reduction,displayed
R5411 T18828 T18827 prep of,reduction
R5412 T18829 T18830 quantmod over,25
R5413 T18900 T18898 dobj model,represents
R5414 T18830 T18831 nummod 25,%
R5415 T18831 T18828 pobj %,of
R5416 T18901 T18900 amod major,model
R5417 T18832 T18827 prep in,reduction
R5418 T18833 T18832 pobj AI,in
R5419 T18834 T18825 punct .,displayed
R542 T2886 T2885 pcomp characterizing,by
R5420 T18902 T18903 npadvmod epistasis,based
R5421 T18903 T18900 amod based,model
R5422 T18904 T18903 punct -,based
R5423 T18905 T18906 amod obese,mouse
R5424 T18906 T18900 compound mouse,model
R5425 T18907 T18898 cc and,represents
R5426 T18908 T18898 conj promises,represents
R5427 T18909 T18910 aux to,aid
R5428 T18910 T18908 xcomp aid,promises
R5429 T18911 T18910 prep in,aid
R543 T3016 T3017 aux to,identify
R5430 T18912 T18913 det the,understanding
R5431 T18913 T18911 pobj understanding,in
R5432 T18914 T18913 prep of,understanding
R5433 T18915 T18914 pobj obesity,of
R5434 T19201 T19202 npadvmod sex,specific
R5435 T18916 T18913 cc and,understanding
R5436 T19202 T19200 amod specific,phenotypes
R5437 T19203 T19202 punct -,specific
R5438 T18917 T18918 advmod specifically,modulation
R5439 T19204 T19200 prep in,phenotypes
R544 T3017 T3011 advcl identify,uses
R5440 T19205 T19206 compound HG11,mice
R5441 T19206 T19204 pobj mice,in
R5442 T18918 T18913 conj modulation,understanding
R5443 T19207 T19208 mark since,is
R5444 T19208 T19192 advcl is,explain
R5445 T18919 T18918 det the,modulation
R5446 T19209 T19208 nsubj it,is
R5447 T19210 T19211 det the,factor
R5448 T19211 T19208 attr factor,is
R5449 T18920 T18918 prep of,modulation
R545 T3018 T3019 amod male,mice
R5450 T19212 T19211 amod primary,factor
R5451 T19213 T19211 compound transcription,factor
R5452 T19214 T19211 amod responsible,factor
R5453 T18921 T18922 compound adipose,tissue
R5454 T19215 T19214 prep for,responsible
R5455 T19216 T19217 npadvmod Gh,induced
R5456 T19217 T19218 amod induced,expression
R5457 T18922 T18923 compound tissue,deposition
R5458 T19218 T19215 pobj expression,for
R5459 T19219 T19220 npadvmod sex,specific
R546 T2887 T2888 amod large,numbers
R5460 T19220 T19218 amod specific,expression
R5461 T18923 T18920 pobj deposition,of
R5462 T19221 T19220 punct -,specific
R5463 T19222 T19223 compound liver,gene
R5464 T18924 T18918 prep by,modulation
R5465 T19223 T19218 compound gene,expression
R5466 T19224 T19225 punct [,44
R5467 T19225 T19192 parataxis 44,explain
R5468 T18925 T18924 pobj Gh,by
R5469 T19226 T19225 punct ],44
R547 T3019 T3017 dobj mice,identify
R5470 T19227 T19192 punct .,explain
R5471 T18926 T18898 punct .,represents
R5472 T19229 T19230 amod Future,studies
R5473 T19230 T19231 nsubj studies,include
R5474 T19232 T19230 acl aimed,studies
R5475 T19233 T19232 prep at,aimed
R5476 T19234 T19233 pcomp identifying,at
R5477 T19235 T19236 det the,QTG
R5478 T19236 T19234 dobj QTG,identifying
R5479 T19237 T19236 compound HG11,QTG
R548 T2888 T2886 dobj numbers,characterizing
R5480 T19238 T19231 punct ", ",include
R5481 T19239 T19231 aux will,include
R5482 T19240 T19231 advmod certainly,include
R5483 T19241 T19242 det a,characterization
R5484 T18928 T18929 nsubj Studies,are
R5485 T19242 T19231 dobj characterization,include
R5486 T19243 T19242 amod thorough,characterization
R5487 T19244 T19242 prep of,characterization
R5488 T19245 T19246 nmod Gh,patterns
R5489 T18930 T18929 advmod currently,are
R549 T3020 T3019 acl inheriting,mice
R5490 T19246 T19244 pobj patterns,of
R5491 T19247 T19245 cc and,Gh
R5492 T19248 T19245 conj Stat5b,Gh
R5493 T19249 T19246 nmod sequence,patterns
R5494 T18931 T18929 acomp underway,are
R5495 T19250 T19249 cc and,sequence
R5496 T19251 T19249 conj expression,sequence
R5497 T18932 T18933 aux to,identify
R5498 T19252 T19246 prep in,patterns
R5499 T19253 T19254 amod congenic,mice
R55 T635 T633 conj 17,11
R550 T3021 T3022 amod fewer,alleles
R5500 T19254 T19252 pobj mice,in
R5501 T18933 T18929 advcl identify,are
R5502 T19255 T19231 punct .,include
R5503 T18934 T18935 det the,mutation
R5504 T19257 T19258 det The,QTL
R5505 T19258 T19261 nsubj QTL,had
R5506 T19259 T19260 compound hg,modifier
R5507 T18935 T18933 dobj mutation,identify
R5508 T19260 T19258 compound modifier,QTL
R5509 T19262 T19258 acl located,QTL
R551 T2889 T2888 prep of,numbers
R5510 T18936 T18935 amod causative,mutation
R5511 T19263 T19262 prep within,located
R5512 T19264 T19265 det the,strain
R5513 T19265 T19263 pobj strain,within
R5514 T18937 T18933 cc and,identify
R5515 T18938 T18939 aux to,characterize
R5516 T19266 T19265 compound HG17,strain
R5517 T18939 T18933 conj characterize,identify
R5518 T19267 T19268 amod large,effects
R5519 T19268 T19261 dobj effects,had
R552 T2890 T2891 advmod genetically,identical
R5520 T18940 T18941 det the,effects
R5521 T19269 T19268 prep on,effects
R5522 T19270 T19269 pobj growth,on
R5523 T19271 T19270 punct ", ",growth
R5524 T18941 T18939 dobj effects,characterize
R5525 T19272 T19273 compound body,length
R5526 T19273 T19270 conj length,growth
R5527 T18942 T18941 prep of,effects
R5528 T19274 T19273 cc and,length
R5529 T19275 T19276 compound carcass,components
R553 T3022 T3020 dobj alleles,inheriting
R5530 T18943 T18942 pobj age,of
R5531 T18944 T18943 cc and,age
R5532 T18945 T18943 conj diet,age
R5533 T19276 T19273 conj components,length
R5534 T18946 T18941 prep on,effects
R5535 T19277 T19261 punct .,had
R5536 T18947 T18946 pobj obesity,on
R5537 T19279 T19280 det The,gene
R5538 T18948 T18947 prep in,obesity
R5539 T19280 T19284 nsubj gene,is
R554 T3023 T3022 compound donor,alleles
R5540 T19281 T19282 advmod most,intriguing
R5541 T19282 T19280 amod intriguing,gene
R5542 T18949 T18950 det this,strain
R5543 T19283 T19280 compound candidate,gene
R5544 T18950 T18948 pobj strain,in
R5545 T19285 T19280 acl located,gene
R5546 T19286 T19285 prep in,located
R5547 T19287 T19288 det the,congenic
R5548 T18951 T18952 advmod as,as
R5549 T19288 T19286 pobj congenic,in
R555 T2891 T2892 amod identical,mice
R5550 T19289 T19284 attr Sstr5,is
R5551 T19290 T19284 punct .,is
R5552 T18952 T18941 cc as,effects
R5553 T19292 T19293 nsubj Somatostatin,is
R5554 T18953 T18952 advmod well,as
R5555 T19294 T19295 det a,inhibitor
R5556 T18954 T18941 conj testing,effects
R5557 T19295 T19293 attr inhibitor,is
R5558 T19296 T19295 amod potent,inhibitor
R5559 T18955 T18954 prep for,testing
R556 T3024 T3022 punct ", ",alleles
R5560 T19297 T19295 prep of,inhibitor
R5561 T19298 T19297 pobj Gh,of
R5562 T19299 T19293 cc and,is
R5563 T18956 T18957 amod other,consequences
R5564 T19300 T19301 nsubj Sstr5,is
R5565 T19301 T19293 conj is,is
R5566 T19302 T19301 attr one,is
R5567 T18957 T18955 pobj consequences,for
R5568 T19303 T19302 prep of,one
R5569 T19304 T19305 nummod five,receptors
R557 T3025 T3026 mark than,expected
R5570 T18958 T18957 amod physiological,consequences
R5571 T19305 T19303 pobj receptors,of
R5572 T19306 T19307 dep which,mediate
R5573 T19307 T19305 relcl mediate,receptors
R5574 T18959 T18960 amod such,as
R5575 T19308 T19309 det these,effects
R5576 T19309 T19307 dobj effects,mediate
R5577 T18960 T18957 prep as,consequences
R5578 T19310 T19311 punct [,46
R5579 T19311 T19301 parataxis 46,is
R558 T3026 T3022 advcl expected,alleles
R5580 T19312 T19311 nummod 45,46
R5581 T19313 T19311 punct ",",46
R5582 T19314 T19311 punct ],46
R5583 T19315 T19301 punct .,is
R5584 T18961 T18960 pobj alterations,as
R5585 T19317 T19318 amod Ubiquitous,knockout
R5586 T18962 T18961 prep in,alterations
R5587 T19318 T19324 nsubj knockout,leads
R5588 T19319 T19317 cc and,Ubiquitous
R5589 T19320 T19321 amod pancreatic,cell
R559 T2892 T2889 pobj mice,of
R5590 T18963 T18964 compound food,intake
R5591 T19321 T19323 npadvmod cell,specific
R5592 T19322 T19321 compound beta,cell
R5593 T19323 T19317 conj specific,Ubiquitous
R5594 T18964 T18962 pobj intake,in
R5595 T19325 T19318 prep of,knockout
R5596 T19326 T19325 pobj Sstr5,of
R5597 T18965 T18964 cc and,intake
R5598 T19327 T19324 prep to,leads
R5599 T19328 T19327 pobj alterations,to
R56 T636 T598 punct .,identified
R560 T3027 T3020 prep on,inheriting
R5600 T18966 T18967 compound insulin,sensitivity
R5601 T19329 T19328 prep in,alterations
R5602 T19330 T19331 compound insulin,secretion
R5603 T19331 T19329 pobj secretion,in
R5604 T18967 T18964 conj sensitivity,intake
R5605 T19332 T19331 cc and,secretion
R5606 T19333 T19334 compound glucose,homeostasis
R5607 T18968 T18929 punct .,are
R5608 T19334 T19331 conj homeostasis,secretion
R5609 T19335 T19336 punct [,48
R561 T3028 T3027 amod average,on
R5610 T19336 T19324 parataxis 48,leads
R5611 T18970 T18971 det The,strain
R5612 T19337 T19336 nummod 47,48
R5613 T19338 T19336 punct ",",48
R5614 T19339 T19336 punct ],48
R5615 T19340 T19324 punct .,leads
R5616 T18971 T18973 nsubj strain,is
R5617 T19342 T19343 nsubj We,sequenced
R5618 T18972 T18971 compound HG11,strain
R5619 T19344 T19345 compound candidate,genes
R562 T3029 T3011 punct ", ",uses
R5620 T19345 T19343 dobj genes,sequenced
R5621 T18974 T18973 prep of,is
R5622 T19346 T19347 compound hg,modifier
R5623 T19347 T19345 compound modifier,genes
R5624 T19348 T19349 aux to,complement
R5625 T19349 T19343 advcl complement,sequenced
R5626 T18975 T18976 amod particular,interest
R5627 T19350 T19351 det the,characterization
R5628 T19351 T19349 dobj characterization,complement
R5629 T18976 T18974 pobj interest,of
R563 T2893 T2865 punct .,accomplished
R5630 T19352 T19351 prep of,characterization
R5631 T19353 T19354 det the,congenics
R5632 T19354 T19352 pobj congenics,of
R5633 T19355 T19354 compound speed,congenics
R5634 T19356 T19354 prep on,congenics
R5635 T19357 T19358 nmod MMU,2
R5636 T18977 T18973 prep for,is
R5637 T19358 T19356 pobj 2,on
R5638 T19359 T19358 punct ", ",2
R5639 T19360 T19358 conj 9,2
R564 T3030 T3011 prep during,uses
R5640 T18978 T18979 det a,number
R5641 T19361 T19360 punct ", ",9
R5642 T19362 T19360 conj 11,9
R5643 T18979 T18977 pobj number,for
R5644 T19363 T19362 cc and,11
R5645 T19364 T19362 conj 17,11
R5646 T18980 T18979 prep of,number
R5647 T18981 T18980 pobj reasons,of
R5648 T18982 T18973 punct .,is
R5649 T18984 T18985 advmod First,demonstrated
R565 T3031 T3032 det each,backcross
R5650 T19365 T19343 punct .,sequenced
R5651 T18986 T18985 punct ", ",demonstrated
R5652 T19367 T19368 det A,number
R5653 T19368 T19370 nsubj number,identified
R5654 T19369 T19368 amod limited,number
R5655 T18987 T18988 npadvmod HG11,congenic
R5656 T19371 T19368 prep of,number
R5657 T18988 T18989 amod congenic,mice
R5658 T18989 T18985 nsubj mice,demonstrated
R5659 T19372 T19371 pobj studies,of
R566 T2895 T2896 det The,Consortium
R5660 T19373 T19370 aux have,identified
R5661 T18990 T18991 amod significant,interactions
R5662 T19374 T19370 dobj variation,identified
R5663 T19375 T19374 prep within,variation
R5664 T18991 T18985 dobj interactions,demonstrated
R5665 T19376 T19377 compound CAST,sequence
R5666 T19377 T19375 pobj sequence,within
R5667 T19378 T19377 compound coding,sequence
R5668 T18992 T18991 nmod strain,interactions
R5669 T19379 T19370 punct ;,identified
R567 T3032 T3030 pobj backcross,during
R5670 T19380 T19370 cc so,identified
R5671 T18993 T18992 prep by,strain
R5672 T19381 T19382 amod sequencing,candidates
R5673 T19382 T19383 nsubj candidates,gave
R5674 T19383 T19370 conj gave,identified
R5675 T18994 T18993 pobj sex,by
R5676 T19384 T19383 dative us,gave
R5677 T19385 T19386 det the,opportunity
R5678 T18995 T18985 prep for,demonstrated
R5679 T19386 T19383 dobj opportunity,gave
R568 T3033 T3011 punct .,uses
R5680 T19387 T19388 aux to,estimate
R5681 T18996 T18997 det a,number
R5682 T19388 T19386 acl estimate,opportunity
R5683 T19389 T19390 det the,frequency
R5684 T19390 T19388 dobj frequency,estimate
R5685 T19391 T19390 compound SNP,frequency
R5686 T19392 T19390 prep in,frequency
R5687 T18997 T18995 pobj number,for
R5688 T19393 T19394 compound coding,sequence
R5689 T19394 T19392 pobj sequence,in
R569 T2896 T2899 nsubj Consortium,considers
R5690 T19395 T19388 advcl relative,estimate
R5691 T18998 T18997 prep of,number
R5692 T19396 T19395 prep to,relative
R5693 T19397 T19396 pobj B6,to
R5694 T19398 T19383 punct .,gave
R5695 T18999 T18998 pobj traits,of
R5696 T19400 T19401 det This,information
R5697 T19000 T18985 punct .,demonstrated
R5698 T19401 T19402 nsubj information,be
R5699 T19403 T19402 aux will,be
R57 T638 T639 aux To,confirm
R570 T3035 T3036 amod Numerous,congenics
R5700 T19002 T19003 nsubj Males,were
R5701 T19404 T19402 acomp vital,be
R5702 T19405 T19404 prep to,vital
R5703 T19406 T19407 amod future,studies
R5704 T19004 T19005 advmod generally,larger
R5705 T19407 T19405 pobj studies,to
R5706 T19408 T19409 amod fine,mapping
R5707 T19409 T19407 compound mapping,studies
R5708 T19410 T19407 punct ", ",studies
R5709 T19005 T19003 acomp larger,were
R571 T3036 T3041 nsubjpass congenics,used
R5710 T19411 T19412 dep which,include
R5711 T19412 T19407 relcl include,studies
R5712 T19413 T19412 aux will,include
R5713 T19006 T19005 punct ", ",larger
R5714 T19414 T19415 compound gene,expression
R5715 T19415 T19416 compound expression,analysis
R5716 T19416 T19412 dobj analysis,include
R5717 T19007 T19008 amod faster,growing
R5718 T19417 T19402 punct .,be
R5719 T19008 T19005 conj growing,larger
R572 T3037 T3038 advmod traditionally,developed
R5720 T19419 T19420 det The,frequency
R5721 T19420 T19423 nsubj frequency,lead
R5722 T19421 T19420 amod high,frequency
R5723 T19009 T19008 cc and,growing
R5724 T19422 T19420 compound SNP,frequency
R5725 T19424 T19425 punct (,SNP
R5726 T19010 T19008 conj longer,growing
R5727 T19425 T19420 parataxis SNP,frequency
R5728 T19426 T19427 nummod 0.312,%
R5729 T19427 T19425 dep %,SNP
R573 T2897 T2898 compound Complex,Trait
R5730 T19011 T19003 cc and,were
R5731 T19428 T19425 punct ;,SNP
R5732 T19429 T19425 nummod 295,SNP
R5733 T19012 T19013 det the,converse
R5734 T19430 T19425 prep in,SNP
R5735 T19431 T19432 nummod 94.492,kbp
R5736 T19432 T19430 pobj kbp,in
R5737 T19433 T19425 punct ),SNP
R5738 T19434 T19420 prep in,frequency
R5739 T19435 T19436 compound CAST,genes
R574 T3038 T3036 amod developed,congenics
R5740 T19013 T19014 nsubjpass converse,seen
R5741 T19436 T19434 pobj genes,in
R5742 T19437 T19423 aux may,lead
R5743 T19438 T19423 prep to,lead
R5744 T19014 T19003 conj seen,were
R5745 T19439 T19440 det a,rate
R5746 T19440 T19438 pobj rate,to
R5747 T19441 T19440 amod higher,rate
R5748 T19442 T19440 prep of,rate
R5749 T19443 T19444 amod false,positives
R575 T3039 T3038 cc and,developed
R5750 T19444 T19442 pobj positives,of
R5751 T19445 T19444 acl using,positives
R5752 T19446 T19447 compound DNA,microarrays
R5753 T19447 T19445 dobj microarrays,using
R5754 T19448 T19447 cc or,microarrays
R5755 T19015 T19014 auxpass was,seen
R5756 T19449 T19450 amod quantitative,assays
R5757 T19016 T19014 prep in,seen
R5758 T19017 T19016 pobj females,in
R5759 T19018 T19014 punct .,seen
R576 T3040 T3038 conj speed,developed
R5760 T19020 T19021 det The,effects
R5761 T19450 T19447 conj assays,microarrays
R5762 T19021 T19023 nsubj effects,are
R5763 T19451 T19452 amod real,time
R5764 T19452 T19450 compound time,assays
R5765 T19453 T19452 punct -,time
R5766 T19022 T19021 amod confounding,effects
R5767 T19454 T19450 compound PCR,assays
R5768 T19455 T19447 punct ", ",microarrays
R5769 T19024 T19021 prep of,effects
R577 T2898 T2896 compound Trait,Consortium
R5770 T19456 T19457 dep most,based
R5771 T19457 T19447 relcl based,microarrays
R5772 T19458 T19456 prep of,most
R5773 T19459 T19458 pobj which,of
R5774 T19025 T19024 pobj sex,of
R5775 T19460 T19457 auxpass are,based
R5776 T19461 T19457 prep on,based
R5777 T19462 T19463 compound B6,sequence
R5778 T19026 T19023 advmod likely,are
R5779 T19463 T19461 pobj sequence,on
R578 T3042 T3041 aux have,used
R5780 T19464 T19423 punct .,lead
R5781 T19027 T19028 det the,reason
R5782 T19466 T19467 advmod Therefore,used
R5783 T19028 T19023 attr reason,are
R5784 T19468 T19467 punct ", ",used
R5785 T19469 T19470 det these,data
R5786 T19470 T19467 nsubjpass data,used
R5787 T19029 T19028 prep for,reason
R5788 T19471 T19470 compound sequence,data
R5789 T19472 T19467 aux can,used
R579 T3043 T3041 auxpass been,used
R5790 T19473 T19467 auxpass be,used
R5791 T19474 T19475 aux to,guide
R5792 T19475 T19467 advcl guide,used
R5793 T19476 T19477 det the,development
R5794 T19030 T19031 det the,discrepancies
R5795 T19477 T19475 dobj development,guide
R5796 T19031 T19029 pobj discrepancies,for
R5797 T19032 T19031 prep between,discrepancies
R5798 T19478 T19477 prep of,development
R5799 T19479 T19480 compound gene,expression
R58 T639 T640 advcl confirm,developed
R580 T2900 T2896 punct (,Consortium
R5800 T19480 T19481 compound expression,assays
R5801 T19033 T19034 det the,results
R5802 T19481 T19478 pobj assays,of
R5803 T19482 T19483 aux to,confirm
R5804 T19034 T19032 pobj results,between
R5805 T19483 T19475 advcl confirm,guide
R5806 T19484 T19485 amod differential,expression
R5807 T19485 T19483 dobj expression,confirm
R5808 T19035 T19036 amod congenic,genome
R5809 T19486 T19483 prep for,confirm
R581 T3044 T3045 aux to,isolate
R5810 T19487 T19486 pobj candidates,for
R5811 T19036 T19038 compound genome,scan
R5812 T19488 T19467 cc and,used
R5813 T19489 T19467 conj suggests,used
R5814 T19037 T19036 cc and,genome
R5815 T19490 T19491 mark that,sequenced
R5816 T19491 T19489 ccomp sequenced,suggests
R5817 T19492 T19491 nsubjpass genes,sequenced
R5818 T19493 T19492 acl identified,genes
R5819 T19038 T19034 compound scan,results
R582 T3045 T3041 advcl isolate,used
R5820 T19494 T19493 prep by,identified
R5821 T19495 T19496 amod downstream,experiments
R5822 T19039 T19034 punct ", ",results
R5823 T19496 T19494 pobj experiments,by
R5824 T19497 T19491 aux should,sequenced
R5825 T19498 T19491 advmod also,sequenced
R5826 T19040 T19041 advmod where,analyzed
R5827 T19499 T19491 auxpass be,sequenced
R5828 T19500 T19467 punct .,used
R5829 T19041 T19034 relcl analyzed,results
R583 T3046 T3045 advmod successfully,isolate
R5830 T19502 T19503 advmod More,importantly
R5831 T19503 T19504 advmod importantly,allowed
R5832 T19042 T19043 det both,sexes
R5833 T19505 T19504 punct ", ",allowed
R5834 T19506 T19504 csubj sequencing,allowed
R5835 T19043 T19041 nsubjpass sexes,analyzed
R5836 T19507 T19508 compound hg,modifier
R5837 T19508 T19509 compound modifier,candidates
R5838 T19509 T19506 dobj candidates,sequencing
R5839 T19044 T19041 auxpass were,analyzed
R584 T3047 T3048 compound mouse,QTL
R5840 T19510 T19511 nsubj us,identify
R5841 T19511 T19504 ccomp identify,allowed
R5842 T19512 T19511 aux to,identify
R5843 T19513 T19514 amod nonsynonomous,polymorphism
R5844 T19514 T19511 dobj polymorphism,identify
R5845 T19515 T19514 punct ", ",polymorphism
R5846 T19045 T19041 advmod together,analyzed
R5847 T19516 T19517 dep which,underlie
R5848 T19517 T19514 relcl underlie,polymorphism
R5849 T19518 T19517 aux may,underlie
R585 T2901 T2896 appos CTC,Consortium
R5850 T19046 T19023 punct .,are
R5851 T19519 T19517 dobj QTL,underlie
R5852 T19520 T19504 punct .,allowed
R5853 T19048 T19049 advmod Secondly,found
R5854 T19522 T19523 nsubj SIFT,predicted
R5855 T19524 T19522 cc and,SIFT
R5856 T19525 T19524 punct /,and
R5857 T19050 T19049 punct ", ",found
R5858 T19526 T19524 cc or,and
R5859 T19527 T19522 conj PolyPhen,SIFT
R586 T3048 T3045 dobj QTL,isolate
R5860 T19528 T19523 dobj alterations,predicted
R5861 T19529 T19528 prep in,alterations
R5862 T19051 T19049 nsubjpass Carp2,found
R5863 T19530 T19531 compound protein,function
R5864 T19531 T19529 pobj function,in
R5865 T19052 T19049 auxpass was,found
R5866 T19532 T19528 prep for,alterations
R5867 T19533 T19532 pobj 15,for
R5868 T19534 T19533 prep of,15
R5869 T19053 T19054 aux to,interact
R587 T3049 T3045 prep for,isolate
R5870 T19535 T19536 det the,nsSNP
R5871 T19536 T19534 pobj nsSNP,of
R5872 T19054 T19049 xcomp interact,found
R5873 T19055 T19054 prep with,interact
R5874 T19056 T19055 pobj hg,with
R5875 T19057 T19049 cc and,found
R5876 T19058 T19059 nsubjpass MMU11,saturated
R5877 T19537 T19536 nummod 56,nsSNP
R5878 T19538 T19536 amod total,nsSNP
R5879 T19059 T19049 conj saturated,found
R588 T2902 T2899 punct ),considers
R5880 T19060 T19059 auxpass is,saturated
R5881 T19061 T19059 prep with,saturated
R5882 T19062 T19061 pobj genes,with
R5883 T19063 T19062 acl involved,genes
R5884 T19539 T19540 punct (,%
R5885 T19064 T19063 prep in,involved
R5886 T19540 T19533 parataxis %,15
R5887 T19541 T19540 nummod 27,%
R5888 T19065 T19066 det the,pathway
R5889 T19542 T19540 punct ),%
R589 T3050 T3051 det a,array
R5890 T19543 T19533 prep in,15
R5891 T19066 T19064 pobj pathway,in
R5892 T19544 T19543 pobj nine,in
R5893 T19545 T19544 prep of,nine
R5894 T19546 T19547 det the,genes
R5895 T19547 T19545 pobj genes,of
R5896 T19548 T19547 nummod 44,genes
R5897 T19067 T19066 amod central,pathway
R5898 T19549 T19547 amod total,genes
R5899 T19550 T19551 punct (,%
R59 T641 T639 cc and,confirm
R590 T3051 T3049 pobj array,for
R5900 T19551 T19543 parataxis %,in
R5901 T19068 T19066 nmod Gh,pathway
R5902 T19552 T19551 nummod 20,%
R5903 T19553 T19551 punct ),%
R5904 T19069 T19066 amod intracellular,pathway
R5905 T19554 T19555 punct (,Table
R5906 T19555 T19523 parataxis Table,predicted
R5907 T19556 T19555 nummod 7,Table
R5908 T19070 T19066 compound signaling,pathway
R5909 T19557 T19555 punct ),Table
R591 T3052 T3051 amod wide,array
R5910 T19558 T19523 punct .,predicted
R5911 T19071 T19062 punct ", ",genes
R5912 T19560 T19561 nsubjpass It,shown
R5913 T19072 T19073 amod such,as
R5914 T19562 T19561 aux has,shown
R5915 T19563 T19561 auxpass been,shown
R5916 T19073 T19062 prep as,genes
R5917 T19564 T19565 mark that,is
R5918 T19565 T19561 ccomp is,shown
R5919 T19566 T19565 csubj predicting,is
R592 T3053 T3051 prep of,array
R5920 T19074 T19073 pobj Gh,as
R5921 T19075 T19074 punct ", ",Gh
R5922 T19076 T19074 conj Stat5b,Gh
R5923 T19077 T19076 cc and,Stat5b
R5924 T19567 T19566 dobj function,predicting
R5925 T19568 T19566 prep based,predicting
R5926 T19078 T19076 conj Stat5a,Stat5b
R5927 T19569 T19568 prep on,based
R5928 T19570 T19571 amod evolutionary,conservation
R5929 T19571 T19569 pobj conservation,on
R593 T3054 T3053 pobj traits,of
R5930 T19079 T19049 punct .,found
R5931 T19572 T19566 advcl using,predicting
R5932 T19573 T19572 dobj programs,using
R5933 T19574 T19575 amod such,as
R5934 T19081 T19082 advmod Thirdly,identified
R5935 T19575 T19573 prep as,programs
R5936 T19576 T19575 pobj SIFT,as
R5937 T19577 T19576 cc and,SIFT
R5938 T19083 T19082 punct ", ",identified
R5939 T19578 T19576 conj PolyPhen,SIFT
R594 T3055 T3051 punct ", ",array
R5940 T19579 T19580 advmod very,accurate
R5941 T19580 T19565 acomp accurate,is
R5942 T19581 T19582 punct [,49
R5943 T19084 T19085 compound MMU11,QTL
R5944 T19582 T19561 parataxis 49,shown
R5945 T19583 T19582 punct ],49
R5946 T19085 T19082 nsubjpass QTL,identified
R5947 T19584 T19561 punct .,shown
R5948 T19586 T19587 nsubj Four,are
R5949 T19086 T19085 compound growth,QTL
R595 T3114 T3115 det The,role
R5950 T19588 T19586 prep of,Four
R5951 T19589 T19590 det the,genes
R5952 T19087 T19085 acl overlapping,QTL
R5953 T19590 T19588 pobj genes,of
R5954 T19591 T19590 nummod nine,genes
R5955 T19088 T19087 dobj HG11,overlapping
R5956 T19592 T19586 punct (,Four
R5957 T19593 T19586 appos Ubr1,Four
R5958 T19594 T19593 punct ", ",Ubr1
R5959 T19089 T19082 aux have,identified
R596 T3056 T3051 prep including,array
R5960 T19595 T19593 conj Ptpns1,Ubr1
R5961 T19596 T19595 punct ", ",Ptpns1
R5962 T19090 T19082 auxpass been,identified
R5963 T19597 T19595 conj Ubce7ip5,Ptpns1
R5964 T19598 T19597 cc and,Ubce7ip5
R5965 T19091 T19082 prep in,identified
R5966 T19599 T19597 conj Mmp9,Ubce7ip5
R5967 T19600 T19593 punct ;,Ubr1
R5968 T19092 T19093 det a,number
R5969 T19601 T19602 dep all,are
R597 T3057 T3056 pobj growth,including
R5970 T19602 T19593 relcl are,Ubr1
R5971 T19603 T19601 prep of,all
R5972 T19093 T19091 pobj number,in
R5973 T19604 T19603 pobj which,of
R5974 T19605 T19602 prep on,are
R5975 T19606 T19605 pobj MMU2,on
R5976 T19094 T19093 prep of,number
R5977 T19607 T19587 punct ),are
R5978 T19608 T19587 prep of,are
R5979 T19609 T19610 amod particular,interest
R598 T3058 T3057 cc and,growth
R5980 T19095 T19094 pobj crosses,of
R5981 T19610 T19608 pobj interest,of
R5982 T19611 T19587 punct .,are
R5983 T19096 T19082 advcl using,identified
R5984 T19613 T19614 nsubjpass It,suggested
R5985 T19097 T19098 amod different,strains
R5986 T19615 T19614 aux has,suggested
R5987 T19616 T19614 auxpass been,suggested
R5988 T19098 T19096 dobj strains,using
R5989 T19617 T19618 det the,Socs2
R599 T3059 T3057 conj obesity,growth
R5990 T19618 T19619 nsubj Socs2,rely
R5991 T19619 T19614 advcl rely,suggested
R5992 T19099 T19098 compound mouse,strains
R5993 T19620 T19619 aux may,rely
R5994 T19621 T19619 prep on,rely
R5995 T19100 T19101 punct [,37
R5996 T19622 T19623 npadvmod ubiquitination,dependent
R5997 T19623 T19624 amod dependent,degradation
R5998 T19624 T19621 pobj degradation,on
R5999 T19625 T19624 amod proteasomal,degradation
R6 T581 T579 cc and,growth
R60 T642 T643 advmod further,characterize
R600 T3115 T3116 nsubjpass role,confirmed
R6000 T19101 T19082 parataxis 37,identified
R6001 T19102 T19103 punct -,41
R6002 T19626 T19627 aux to,inhibit
R6003 T19627 T19619 advcl inhibit,rely
R6004 T19628 T19629 compound Gh,signaling
R6005 T19629 T19627 dobj signaling,inhibit
R6006 T19630 T19631 punct [,23
R6007 T19103 T19101 prep 41,37
R6008 T19631 T19614 parataxis 23,suggested
R6009 T19632 T19631 punct ],23
R601 T3060 T3061 punct [,7
R6010 T19633 T19614 punct .,suggested
R6011 T19104 T19101 punct ],37
R6012 T19635 T19636 nsubjpass Ubr1,involved
R6013 T19105 T19082 punct .,identified
R6014 T19637 T19635 cc and,Ubr1
R6015 T19638 T19635 conj Ubce7ip5,Ubr1
R6016 T19107 T19108 advcl Given,is
R6017 T19639 T19636 auxpass are,involved
R6018 T19640 T19636 advmod both,involved
R6019 T19641 T19636 prep in,involved
R602 T3061 T3041 parataxis 7,used
R6020 T19642 T19643 compound protein,ubiquitination
R6021 T19109 T19110 det the,nature
R6022 T19643 T19641 pobj ubiquitination,in
R6023 T19644 T19636 cc and,involved
R6024 T19645 T19646 compound Ubr1,knockout
R6025 T19646 T19647 compound knockout,mice
R6026 T19110 T19107 dobj nature,Given
R6027 T19647 T19648 nsubj mice,show
R6028 T19648 T19636 conj show,involved
R6029 T19111 T19112 advmod well,documented
R603 T3062 T3063 punct -,13
R6030 T19649 T19650 det an,decrease
R6031 T19650 T19648 dobj decrease,show
R6032 T19651 T19652 nummod 20,%
R6033 T19112 T19110 amod documented,nature
R6034 T19652 T19650 compound %,decrease
R6035 T19653 T19650 prep in,decrease
R6036 T19654 T19655 compound body,weight
R6037 T19113 T19114 advmod sexually,dimorphic
R6038 T19655 T19653 pobj weight,in
R6039 T19656 T19657 advmod partly,due
R604 T3117 T3115 prep of,role
R6040 T19114 T19110 amod dimorphic,nature
R6041 T19657 T19648 prep due,show
R6042 T19658 T19657 pcomp to,due
R6043 T19659 T19660 det a,reduction
R6044 T19115 T19110 prep of,nature
R6045 T19660 T19657 pobj reduction,due
R6046 T19661 T19660 prep in,reduction
R6047 T19116 T19117 compound Gh,secretion
R6048 T19662 T19663 compound adipose,tissue
R6049 T19663 T19661 pobj tissue,in
R605 T3063 T3061 prep 13,7
R6050 T19664 T19665 punct [,51
R6051 T19665 T19648 parataxis 51,show
R6052 T19666 T19665 nummod 50,51
R6053 T19667 T19665 punct ",",51
R6054 T19117 T19115 pobj secretion,of
R6055 T19668 T19665 punct ],51
R6056 T19669 T19648 punct .,show
R6057 T19118 T19117 cc and,secretion
R6058 T19671 T19672 compound Ptpns1,mice
R6059 T19672 T19674 nsubj mice,displayed
R606 T3064 T3061 punct ],7
R6060 T19119 T19120 npadvmod Gh,induced
R6061 T19673 T19672 compound knockout,mice
R6062 T19120 T19121 amod induced,expression
R6063 T19675 T19676 det a,reduction
R6064 T19676 T19674 dobj reduction,displayed
R6065 T19677 T19678 nummod 10,%
R6066 T19121 T19117 conj expression,secretion
R6067 T19678 T19676 compound %,reduction
R6068 T19679 T19676 prep in,reduction
R6069 T19680 T19681 compound body,weight
R607 T3065 T3041 punct .,used
R6070 T19122 T19121 compound gene,expression
R6071 T19681 T19679 pobj weight,in
R6072 T19682 T19683 punct [,52
R6073 T19123 T19124 punct [,43
R6074 T19683 T19674 parataxis 52,displayed
R6075 T19684 T19683 punct ],52
R6076 T19685 T19674 cc and,displayed
R6077 T19124 T19107 parataxis 43,Given
R6078 T19686 T19687 compound Mmp9,mice
R6079 T19687 T19689 nsubj mice,show
R608 T3067 T3068 det The,mouse
R6080 T19125 T19124 nummod 42,43
R6081 T19688 T19687 compound knockout,mice
R6082 T19689 T19674 conj show,displayed
R6083 T19126 T19124 punct ",",43
R6084 T19127 T19124 punct ],43
R6085 T19690 T19691 det a,reduction
R6086 T19691 T19689 dobj reduction,show
R6087 T19128 T19108 punct ", ",is
R6088 T19692 T19691 prep in,reduction
R6089 T19693 T19692 pobj size,in
R609 T3118 T3117 pobj Socs2,of
R6090 T19694 T19691 cc and,reduction
R6091 T19129 T19108 nsubj it,is
R6092 T19695 T19696 advmod drastically,reduced
R6093 T19696 T19697 amod reduced,length
R6094 T19130 T19108 acomp probable,is
R6095 T19697 T19691 conj length,reduction
R6096 T19698 T19697 compound bone,length
R6097 T19699 T19700 punct [,53
R6098 T19131 T19132 mark that,reside
R6099 T19700 T19689 parataxis 53,show
R61 T643 T639 conj characterize,confirm
R610 T3068 T3079 nsubj mouse,is
R6100 T19701 T19700 punct ],53
R6101 T19702 T19689 punct .,show
R6102 T19132 T19108 ccomp reside,is
R6103 T19704 T19705 nsubj All,are
R6104 T19706 T19704 prep of,All
R6105 T19133 T19134 det the,mutation
R6106 T19707 T19708 det these,genes
R6107 T19708 T19706 pobj genes,of
R6108 T19134 T19132 nsubj mutation,reside
R6109 T19709 T19710 amod excellent,genes
R611 T3069 T3070 nmod C57Bl,hg
R6110 T19135 T19134 amod underlying,mutation
R6111 T19136 T19134 prep in,mutation
R6112 T19710 T19705 attr genes,are
R6113 T19137 T19138 det the,HG11
R6114 T19711 T19710 amod functional,genes
R6115 T19712 T19711 cc and,functional
R6116 T19138 T19136 pobj HG11,in
R6117 T19713 T19711 conj positional,functional
R6118 T19714 T19715 compound hg,modifier
R6119 T19139 T19138 amod congenic,HG11
R612 T3070 T3068 nmod hg,mouse
R6120 T19715 T19710 compound modifier,genes
R6121 T19716 T19710 compound candidate,genes
R6122 T19717 T19705 cc and,are
R6123 T19140 T19132 aux may,reside
R6124 T19718 T19719 det this,information
R6125 T19719 T19720 nsubjpass information,incorporated
R6126 T19141 T19132 prep in,reside
R6127 T19720 T19705 conj incorporated,are
R6128 T19721 T19720 aux can,incorporated
R6129 T19722 T19720 auxpass be,incorporated
R613 T3119 T3115 prep in,role
R6130 T19723 T19720 prep into,incorporated
R6131 T19724 T19725 amod future,studies
R6132 T19142 T19143 det a,gene
R6133 T19725 T19723 pobj studies,into
R6134 T19726 T19727 amod fine,mapping
R6135 T19727 T19725 compound mapping,studies
R6136 T19728 T19720 punct .,incorporated
R6137 T19143 T19141 pobj gene,in
R6138 T19144 T19143 acl enhancing,gene
R6139 T19145 T19146 npadvmod Gh,induced
R614 T3071 T3070 punct /,hg
R6140 T19146 T19147 amod induced,effects
R6141 T19147 T19144 dobj effects,enhancing
R6142 T19148 T19149 npadvmod sex,specific
R6143 T19149 T19147 amod specific,effects
R6144 T19150 T19149 punct -,specific
R6145 T19151 T19108 punct .,is
R6146 T19153 T19154 det The,gene
R6147 T19154 T19157 nsubj gene,are
R6148 T19155 T19154 amod structural,gene
R6149 T19156 T19154 compound Gh,gene
R615 T3072 T3070 nmod 6J,hg
R6150 T19158 T19154 appos itself,gene
R6151 T19159 T19154 cc and,gene
R6152 T19160 T19154 conj Stat5b,gene
R6153 T19161 T19162 amod excellent,candidates
R6154 T19162 T19157 attr candidates,are
R6155 T19163 T19157 punct .,are
R6156 T19165 T19166 det The,role
R6157 T19166 T19168 nsubj role,include
R6158 T19167 T19166 amod potential,role
R6159 T19169 T19166 prep of,role
R616 T3073 T3070 punct -,hg
R6160 T19170 T19169 pobj Gh,of
R6161 T19171 T19168 aux would,include
R6162 T19172 T19168 dobj polymorphism,include
R6163 T19173 T19174 dep that,alters
R6164 T19174 T19172 advcl alters,polymorphism
R6165 T19175 T19176 compound protein,function
R6166 T19176 T19174 dobj function,alters
R6167 T19177 T19174 prep in,alters
R6168 T19178 T19179 det the,absence
R6169 T19179 T19177 pobj absence,in
R617 T3074 T3070 nmod hg,hg
R6170 T19180 T19179 prep of,absence
R6171 T19181 T19180 pobj Socs2,of
R6172 T19182 T19174 cc or,alters
R6173 T19183 T19184 dep that,causes
R6174 T19184 T19174 conj causes,alters
R6175 T19185 T19186 amod transcriptional,deregulation
R6176 T19186 T19184 dobj deregulation,causes
R6177 T19187 T19186 prep of,deregulation
R6178 T19188 T19187 pobj Gh,of
R6179 T19189 T19168 punct .,include
R618 T3120 T3121 det the,phenotype
R6180 T19191 T19192 advmod Additionally,explain
R6181 T19193 T19192 punct ", ",explain
R6182 T19194 T19195 amod functional,variation
R6183 T19195 T19192 nsubj variation,explain
R6184 T19196 T19195 prep in,variation
R6185 T19197 T19196 pobj Stat5b,in
R6186 T19198 T19192 aux may,explain
R6187 T19199 T19200 det the,phenotypes
R6188 T19200 T19192 dobj phenotypes,explain
R6189 T19896 T19897 det The,strains
R619 T3075 T3070 punct /,hg
R6190 T19897 T19900 nsubj strains,confirm
R6191 T19898 T19899 npadvmod speed,congenic
R6192 T19899 T19897 amod congenic,strains
R6193 T19901 T19897 acl developed,strains
R6194 T19902 T19901 advmod herein,developed
R6195 T19903 T19904 advmod previously,identified
R6196 T19904 T19905 amod identified,QTL
R6197 T19905 T19900 dobj QTL,confirm
R6198 T19906 T19907 npadvmod genome,wide
R6199 T19907 T19905 amod wide,QTL
R62 T644 T645 det each,QTL
R620 T3076 T3077 punct (,HG
R6200 T19908 T19907 punct -,wide
R6201 T19909 T19905 acl affecting,QTL
R6202 T19910 T19909 dobj growth,affecting
R6203 T19911 T19910 punct ", ",growth
R6204 T19912 T19910 conj obesity,growth
R6205 T19913 T19912 cc and,obesity
R6206 T19914 T19915 compound carcass,composition
R6207 T19915 T19912 conj composition,obesity
R6208 T19916 T19900 punct .,confirm
R6209 T19918 T19919 poss Our,approach
R621 T3077 T3070 parataxis HG,hg
R6210 T19919 T19923 nsubj approach,provided
R6211 T19920 T19919 amod novel,approach
R6212 T19921 T19922 amod congenic,development
R6213 T19922 T19919 compound development,approach
R6214 T19924 T19919 prep on,approach
R6215 T19925 T19924 pobj MMU2,on
R6216 T19926 T19923 dobj confirmation,provided
R6217 T19927 T19926 prep of,confirmation
R6218 T19928 T19929 compound QTL,hg
R6219 T19929 T19931 compound hg,interactions
R622 T3121 T3119 pobj phenotype,in
R6220 T19930 T19929 punct -,hg
R6221 T19931 T19927 pobj interactions,of
R6222 T19932 T19926 punct ", ",confirmation
R6223 T19933 T19934 dep which,aid
R6224 T19934 T19926 relcl aid,confirmation
R6225 T19935 T19934 aux will,aid
R6226 T19936 T19934 advmod significantly,aid
R6227 T19937 T19934 prep in,aid
R6228 T19938 T19939 amod future,experiments
R6229 T19939 T19937 pobj experiments,in
R623 T3078 T3077 punct ),HG
R6230 T19940 T19941 amod fine,mapping
R6231 T19941 T19939 compound mapping,experiments
R6232 T19942 T19923 punct .,provided
R6233 T19944 T19945 det The,identification
R6234 T19945 T19946 nsubj identification,provide
R6235 T19947 T19945 prep of,identification
R6236 T19948 T19949 det the,mediators
R6237 T19949 T19947 pobj mediators,of
R6238 T19950 T19949 amod molecular,mediators
R6239 T19951 T19949 prep of,mediators
R624 T3080 T3081 det a,model
R6240 T19952 T19953 compound QTL,hg
R6241 T19953 T19955 compound hg,epistasis
R6242 T19954 T19953 punct -,hg
R6243 T19955 T19951 pobj epistasis,of
R6244 T19956 T19957 advmod as,as
R6245 T19957 T19949 cc as,mediators
R6246 T19958 T19957 advmod well,as
R6247 T19959 T19960 det the,QTG
R6248 T19960 T19949 conj QTG,mediators
R6249 T19961 T19960 prep for,QTG
R625 T3122 T3121 compound HG,phenotype
R6250 T19962 T19963 det the,congenics
R6251 T19963 T19961 pobj congenics,for
R6252 T19964 T19963 amod remaining,congenics
R6253 T19965 T19946 aux will,provide
R6254 T19966 T19967 amod essential,information
R6255 T19967 T19946 dobj information,provide
R6256 T19968 T19967 prep on,information
R6257 T19969 T19970 det the,architecture
R6258 T19970 T19968 pobj architecture,on
R6259 T19971 T19970 amod molecular,architecture
R626 T3081 T3079 attr model,is
R6260 T19972 T19970 amod genetic,architecture
R6261 T19973 T19970 prep of,architecture
R6262 T19974 T19973 pobj growth,of
R6263 T19975 T19974 cc and,growth
R6264 T19976 T19974 conj obesity,growth
R6265 T19977 T19946 punct .,provide
R6266 T20228 T20229 compound Mouse,strains
R6267 T20230 T20229 cc and,strains
R6268 T20231 T20229 conj husbandry,strains
R6269 T20233 T20234 nmod CAST,EiJ
R627 T3082 T3081 prep of,model
R6270 T20234 T20236 nmod EiJ,mice
R6271 T20235 T20234 punct /,EiJ
R6272 T20236 T20242 nsubjpass mice,purchased
R6273 T20237 T20238 punct (,#
R6274 T20238 T20236 parataxis #,mice
R6275 T20239 T20238 compound stock,#
R6276 T20240 T20238 nummod 000928,#
R6277 T20241 T20238 punct ),#
R6278 T20243 T20242 auxpass were,purchased
R6279 T20244 T20242 prep from,purchased
R628 T3083 T3084 amod systemic,overgrowth
R6280 T20245 T20246 det the,Laboratory
R6281 T20246 T20244 pobj Laboratory,from
R6282 T20247 T20246 compound Jackson,Laboratory
R6283 T20248 T20242 punct .,purchased
R6284 T20250 T20251 det The,mutation
R6285 T20251 T20253 nsubjpass mutation,identified
R6286 T20252 T20251 compound hg,mutation
R6287 T20254 T20253 auxpass was,identified
R6288 T20255 T20253 advmod originally,identified
R6289 T20256 T20253 prep in,identified
R629 T3123 T3116 auxpass was,confirmed
R6290 T20257 T20258 det a,line
R6291 T20258 T20256 pobj line,in
R6292 T20259 T20258 amod selected,line
R6293 T20260 T20258 compound outcross,line
R6294 T20261 T20262 punct [,22
R6295 T20262 T20253 parataxis 22,identified
R6296 T20263 T20262 punct ],22
R6297 T20264 T20253 cc and,identified
R6298 T20265 T20266 aux has,introgressed
R6299 T20266 T20253 conj introgressed,identified
R63 T645 T643 dobj QTL,characterize
R630 T3084 T3082 pobj overgrowth,of
R6300 T20267 T20266 auxpass been,introgressed
R6301 T20268 T20266 prep onto,introgressed
R6302 T20269 T20270 det a,background
R6303 T20270 T20268 pobj background,onto
R6304 T20271 T20270 compound B6,background
R6305 T20272 T20266 prep via,introgressed
R6306 T20273 T20274 nummod nine,backcrosses
R6307 T20274 T20272 pobj backcrosses,via
R6308 T20275 T20276 aux to,create
R6309 T20276 T20266 advcl create,introgressed
R631 T3085 T3081 acl resulting,model
R6310 T20277 T20278 det the,strain
R6311 T20278 T20276 dobj strain,create
R6312 T20279 T20278 compound HG,strain
R6313 T20280 T20253 punct .,identified
R6314 T20282 T20283 compound HG,mice
R6315 T20283 T20284 nsubj mice,were
R6316 T20285 T20283 acl used,mice
R6317 T20286 T20285 prep in,used
R6318 T20287 T20288 det this,experiment
R6319 T20288 T20286 pobj experiment,in
R632 T3124 T3116 agent by,confirmed
R6320 T20289 T20284 prep from,were
R6321 T20290 T20291 det the,generation
R6322 T20291 T20289 pobj generation,from
R6323 T20292 T20291 amod 17th,generation
R6324 T20293 T20292 cc or,17th
R6325 T20294 T20292 conj later,17th
R6326 T20295 T20291 prep of,generation
R6327 T20296 T20295 pobj inbreeding,of
R6328 T20297 T20284 punct .,were
R6329 T20299 T20300 nsubjpass Mice,housed
R633 T3086 T3085 prep from,resulting
R6330 T20301 T20300 auxpass were,housed
R6331 T20302 T20300 prep in,housed
R6332 T20303 T20304 compound polycarbonate,cages
R6333 T20304 T20302 pobj cages,in
R6334 T20305 T20300 prep under,housed
R6335 T20306 T20307 amod controlled,conditions
R6336 T20307 T20305 pobj conditions,under
R6337 T20308 T20307 prep of,conditions
R6338 T20309 T20308 pobj temperature,of
R6339 T20310 T20311 punct (,°C
R634 T3087 T3088 det a,deletion
R6340 T20311 T20309 parataxis °C,temperature
R6341 T20312 T20311 nummod 21,°C
R6342 T20313 T20311 punct ±,°C
R6343 T20314 T20315 nummod 2,°C
R6344 T20315 T20311 appos °C,°C
R6345 T20316 T20311 punct ),°C
R6346 T20317 T20309 punct ", ",temperature
R6347 T20318 T20309 conj humidity,temperature
R6348 T20319 T20320 punct (,%
R6349 T20320 T20318 parataxis %,humidity
R635 T3088 T3086 pobj deletion,from
R6350 T20321 T20322 quantmod 40,70
R6351 T20322 T20320 nummod 70,%
R6352 T20323 T20322 punct –,70
R6353 T20324 T20320 punct ),%
R6354 T20325 T20318 cc and,humidity
R6355 T20326 T20318 conj lighting,humidity
R6356 T20327 T20328 punct (,dark
R6357 T20328 T20326 parataxis dark,lighting
R6358 T20329 T20330 nummod 14,h
R6359 T20330 T20331 compound h,light
R636 T3125 T3126 det an,mouse
R6360 T20331 T20328 dep light,dark
R6361 T20332 T20328 punct ", ",dark
R6362 T20333 T20334 nummod 10,h
R6363 T20334 T20328 compound h,dark
R6364 T20335 T20328 punct ", ",dark
R6365 T20336 T20337 nsubj lights,on
R6366 T20337 T20328 advmod on,dark
R6367 T20338 T20337 prep at,on
R6368 T20339 T20340 nummod 7,AM
R6369 T20340 T20338 pobj AM,at
R637 T3089 T3088 amod spontaneous,deletion
R6370 T20341 T20328 punct ),dark
R6371 T20342 T20300 punct ", ",housed
R6372 T20343 T20300 cc and,housed
R6373 T20344 T20300 conj managed,housed
R6374 T20345 T20344 prep according,managed
R6375 T20346 T20345 prep to,according
R6376 T20347 T20348 det the,guidelines
R6377 T20348 T20346 pobj guidelines,to
R6378 T20349 T20348 prep of,guidelines
R6379 T20350 T20351 det the,Association
R638 T3090 T3088 prep on,deletion
R6380 T20351 T20349 pobj Association,of
R6381 T20352 T20351 compound American,Association
R6382 T20353 T20351 prep for,Association
R6383 T20354 T20353 pobj Accreditation,for
R6384 T20355 T20354 prep of,Accreditation
R6385 T20356 T20357 compound Laboratory,Animal
R6386 T20357 T20358 compound Animal,Care
R6387 T20358 T20355 pobj Care,of
R6388 T20359 T20351 punct (,Association
R6389 T20360 T20351 appos AAALAC,Association
R639 T3091 T3090 pobj MMU10,on
R6390 T20361 T20300 punct ),housed
R6391 T20362 T20300 punct .,housed
R6392 T20781 T20782 nsubjpass DNA,isolated
R6393 T20783 T20781 prep for,DNA
R6394 T20784 T20783 pobj genotyping,for
R6395 T20785 T20782 auxpass was,isolated
R6396 T20786 T20782 prep from,isolated
R6397 T20787 T20788 quantmod 1.0,2.0
R6398 T20788 T20790 nummod 2.0,mm
R6399 T20789 T20788 punct –,2.0
R64 T646 T640 punct ", ",developed
R640 T3126 T3124 pobj mouse,by
R6400 T20790 T20791 compound mm,clips
R6401 T20791 T20786 pobj clips,from
R6402 T20792 T20791 compound tail,clips
R6403 T20793 T20782 prep by,isolated
R6404 T20794 T20793 pcomp digesting,by
R6405 T20795 T20794 prep with,digesting
R6406 T20796 T20797 compound Proteinase,K
R6407 T20797 T20795 pobj K,with
R6408 T20798 T20799 punct (,Fisher
R6409 T20799 T20797 parataxis Fisher,K
R641 T3092 T3091 punct ", ",MMU10
R6410 T20800 T20799 punct ),Fisher
R6411 T20801 T20794 prep at,digesting
R6412 T20802 T20803 nummod 55,°C
R6413 T20803 T20801 pobj °C,at
R6414 T20804 T20794 prep in,digesting
R6415 T20805 T20806 det a,buffer
R6416 T20806 T20804 pobj buffer,in
R6417 T20807 T20806 acl composed,buffer
R6418 T20808 T20807 prep of,composed
R6419 T20809 T20810 nummod 0.45,%
R642 T3093 T3094 dep which,eliminates
R6420 T20810 T20811 compound %,NP40
R6421 T20811 T20808 pobj NP40,of
R6422 T20812 T20813 punct (,Sigma
R6423 T20813 T20811 parataxis Sigma,NP40
R6424 T20814 T20813 punct ),Sigma
R6425 T20815 T20811 punct ", ",NP40
R6426 T20816 T20817 nummod 0.45,%
R6427 T20817 T20818 compound %,Tween
R6428 T20818 T20811 conj Tween,NP40
R6429 T20819 T20818 nummod 20,Tween
R643 T3094 T3091 relcl eliminates,MMU10
R6430 T20820 T20821 punct (,Fisher
R6431 T20821 T20818 parataxis Fisher,Tween
R6432 T20822 T20821 punct ),Fisher
R6433 T20823 T20818 cc and,Tween
R6434 T20824 T20825 compound 1X,buffer
R6435 T20825 T20818 conj buffer,Tween
R6436 T20826 T20825 compound PCR,buffer
R6437 T20827 T20828 punct (,Promega
R6438 T20828 T20825 parataxis Promega,buffer
R6439 T20829 T20828 punct ),Promega
R644 T3095 T3094 dobj expression,eliminates
R6440 T20830 T20782 punct .,isolated
R6441 T20832 T20833 det The,product
R6442 T20833 T20834 nsubjpass product,diluted
R6443 T20835 T20833 prep of,product
R6444 T20836 T20837 det this,digestion
R6445 T20837 T20835 pobj digestion,of
R6446 T20838 T20834 auxpass was,diluted
R6447 T20839 T20840 punct (,1
R6448 T20840 T20834 parataxis 1,diluted
R6449 T20841 T20842 punct :,10
R645 T3096 T3095 prep of,expression
R6450 T20842 T20840 prep 10,1
R6451 T20843 T20840 punct ),1
R6452 T20844 T20834 prep in,diluted
R6453 T20845 T20846 amod sterile,H2O
R6454 T20846 T20844 pobj H2O,in
R6455 T20847 T20834 cc and,diluted
R6456 T20848 T20834 conj used,diluted
R6457 T20849 T20848 prep for,used
R6458 T20850 T20849 pobj genotyping,for
R6459 T20851 T20848 prep without,used
R646 T3097 T3098 det the,gene
R6460 T20852 T20853 amod further,purification
R6461 T20853 T20851 pobj purification,without
R6462 T20854 T20834 punct .,diluted
R6463 T20856 T20857 compound Microsatellite,genotyping
R6464 T20857 T20858 nsubjpass genotyping,performed
R6465 T20859 T20858 auxpass was,performed
R6466 T20860 T20858 advcl using,performed
R6467 T20861 T20862 amod standard,protocols
R6468 T20862 T20860 dobj protocols,using
R6469 T20863 T20862 nmod PCR,protocols
R647 T3127 T3128 advmod independently,engineered
R6470 T20864 T20863 cc and,PCR
R6471 T20865 T20866 compound gel,electrophoresis
R6472 T20866 T20863 conj electrophoresis,PCR
R6473 T20867 T20858 punct .,performed
R6474 T20869 T20870 compound Reaction,conditions
R6475 T20870 T20871 nsubjpass conditions,listed
R6476 T20872 T20870 prep for,conditions
R6477 T20873 T20874 det each,marker
R6478 T20874 T20872 pobj marker,for
R6479 T20875 T20871 auxpass are,listed
R648 T3098 T3096 pobj gene,of
R6480 T20876 T20871 prep in,listed
R6481 T20877 T20878 amod Additional,1
R6482 T20878 T20876 pobj 1,in
R6483 T20879 T20878 nmod File,1
R6484 T20880 T20878 cc and,1
R6485 T20881 T20878 conj 2,1
R6486 T20882 T20871 punct .,listed
R6487 T20884 T20885 npadvmod MMU2,congenic
R6488 T20885 T20886 amod congenic,mice
R6489 T20886 T20887 nsubjpass mice,genotyped
R649 T3099 T3098 nmod Socs2,gene
R6490 T20888 T20887 auxpass were,genotyped
R6491 T20889 T20887 prep for,genotyped
R6492 T20890 T20889 pobj hg,for
R6493 T20891 T20887 advcl using,genotyped
R6494 T20892 T20893 det a,assay
R6495 T20893 T20891 dobj assay,using
R6496 T20894 T20895 nummod two,primer
R6497 T20895 T20893 compound primer,assay
R6498 T20896 T20893 compound genotyping,assay
R6499 T20897 T20887 punct .,genotyped
R65 T647 T648 nummod two,panels
R650 T3100 T3099 punct (,Socs2
R6500 T20899 T20900 nummod One,set
R6501 T20900 T20902 nsubj set,spanned
R6502 T20901 T20900 compound primer,set
R6503 T20903 T20900 punct (,set
R6504 T20904 T20905 compound HG,F
R6505 T20905 T20900 appos F,set
R6506 T20906 T20905 punct -,F
R6507 T20907 T20905 punct ", ",F
R6508 T20908 T20905 appos ctcctgtctgggctgtgag,F
R6509 T20909 T20905 cc and,F
R651 T3101 T3099 appos suppressor,Socs2
R6510 T20910 T20911 compound HG,R
R6511 T20911 T20905 conj R,F
R6512 T20912 T20911 punct -,R
R6513 T20913 T20911 punct ", ",R
R6514 T20914 T20911 appos caaaggcagaagtggggtaa,R
R6515 T20915 T20902 punct ),spanned
R6516 T20916 T20917 det the,deletion
R6517 T20917 T20902 dobj deletion,spanned
R6518 T20918 T20917 compound hg,deletion
R6519 T20919 T20902 advcl producing,spanned
R652 T3128 T3126 amod engineered,mouse
R6520 T20920 T20921 det a,product
R6521 T20921 T20919 dobj product,producing
R6522 T20922 T20923 nummod 447,bp
R6523 T20923 T20921 compound bp,product
R6524 T20924 T20919 prep in,producing
R6525 T20925 T20926 nmod hg,hg
R6526 T20926 T20928 nmod hg,mice
R6527 T20927 T20926 punct /,hg
R6528 T20928 T20924 pobj mice,in
R6529 T20929 T20926 cc and,hg
R653 T3102 T3101 prep of,suppressor
R6530 T20930 T20931 punct +,hg
R6531 T20931 T20926 conj hg,hg
R6532 T20932 T20931 punct /,hg
R6533 T20933 T20902 punct .,spanned
R6534 T20935 T20936 det The,set
R6535 T20936 T20938 nsubj set,amplified
R6536 T20937 T20936 amod other,set
R6537 T20939 T20936 punct (,set
R6538 T20940 T20936 appos CRADD3a.F,set
R6539 T20941 T20940 punct ", ",CRADD3a.F
R654 T3103 T3104 compound cytokine,signaling
R6540 T20942 T20940 appos gtccatcagcattcctgaaa,CRADD3a.F
R6541 T20943 T20940 cc and,CRADD3a.F
R6542 T20944 T20940 conj CRADD3.R,CRADD3a.F
R6543 T20945 T20944 punct ", ",CRADD3.R
R6544 T20946 T20944 appos tgtccagcaacagcattgtc,CRADD3.R
R6545 T20947 T20938 punct ),amplified
R6546 T20948 T20949 det a,amplicon
R6547 T20949 T20938 dobj amplicon,amplified
R6548 T20950 T20951 nummod 232,bp
R6549 T20951 T20949 compound bp,amplicon
R655 T3104 T3102 pobj signaling,of
R6550 T20952 T20949 compound Cradd,amplicon
R6551 T20953 T20949 punct (,amplicon
R6552 T20954 T20949 acl located,amplicon
R6553 T20955 T20954 prep within,located
R6554 T20956 T20957 det the,deletion
R6555 T20957 T20955 pobj deletion,within
R6556 T20958 T20957 compound hg,deletion
R6557 T20959 T20938 punct ),amplified
R6558 T20960 T20938 prep in,amplified
R6559 T20961 T20962 punct +,+
R656 T3129 T3130 nmod Socs2,knockout
R6560 T20962 T20964 punct +,mice
R6561 T20963 T20962 punct /,+
R6562 T20964 T20960 pobj mice,in
R6563 T20965 T20962 cc and,+
R6564 T20966 T20967 punct +,hg
R6565 T20967 T20962 conj hg,+
R6566 T20968 T20967 punct /,hg
R6567 T20969 T20970 punct [,54
R6568 T20970 T20938 parataxis 54,amplified
R6569 T20971 T20970 punct ],54
R657 T3105 T3104 nummod 2,signaling
R6570 T20972 T20938 punct .,amplified
R6571 T20974 T20975 det The,temperature
R6572 T20975 T20978 nsubj temperature,was
R6573 T20976 T20977 npadvmod PCR,annealing
R6574 T20977 T20975 amod annealing,temperature
R6575 T20979 T20980 nummod 55,°C
R6576 T20980 T20978 attr °C,was
R6577 T20981 T20978 cc and,was
R6578 T20982 T20983 det the,concentration
R6579 T20983 T20985 nsubj concentration,was
R658 T3106 T3098 punct ),gene
R6580 T20984 T20983 compound MgCl2,concentration
R6581 T20985 T20978 conj was,was
R6582 T20986 T20987 nummod 1.5,mM
R6583 T20987 T20985 attr mM,was
R6584 T20988 T20985 punct .,was
R6585 T21608 T21607 prep of,Development
R6586 T21609 T21610 nmod B6.CAST,MMU2
R6587 T21610 T21613 nmod MMU2,strains
R6588 T21611 T21609 cc and,B6.CAST
R6589 T21612 T21609 conj HG.CAST,B6.CAST
R659 T3107 T3108 punct [,14
R6590 T21613 T21608 pobj strains,of
R6591 T21614 T21615 npadvmod speed,congenic
R6592 T21615 T21613 amod congenic,strains
R6593 T21617 T21618 det All,strains
R6594 T21618 T21621 nsubjpass strains,developed
R6595 T21619 T21620 npadvmod speed,congenic
R6596 T21620 T21618 amod congenic,strains
R6597 T21622 T21621 auxpass were,developed
R6598 T21623 T21621 advcl starting,developed
R6599 T21624 T21623 prep with,starting
R66 T648 T640 nsubjpass panels,developed
R660 T3130 T3126 compound knockout,mouse
R6600 T21625 T21626 det an,cross
R6601 T21626 T21624 pobj cross,with
R6602 T21627 T21626 amod initial,cross
R6603 T21628 T21626 prep between,cross
R6604 T21629 T21630 det a,male
R6605 T21630 T21628 pobj male,between
R6606 T21631 T21630 compound CAST,male
R6607 T21632 T21630 cc and,male
R6608 T21633 T21634 compound HG,females
R6609 T21634 T21630 conj females,male
R661 T3131 T3129 punct -,Socs2
R6610 T21635 T21636 punct (,Figure
R6611 T21636 T21623 parataxis Figure,starting
R6612 T21637 T21636 nummod 1,Figure
R6613 T21638 T21636 punct ),Figure
R6614 T21639 T21640 punct [,6
R6615 T21640 T21621 parataxis 6,developed
R6616 T21641 T21640 nummod 5,6
R6617 T21642 T21640 punct ",",6
R6618 T21643 T21640 punct ],6
R6619 T21644 T21621 punct .,developed
R662 T3108 T3079 parataxis 14,is
R6620 T21646 T21647 amod Male,mice
R6621 T21647 T21649 nsubjpass mice,backcrossed
R6622 T21648 T21647 compound F1,mice
R6623 T21650 T21649 auxpass were,backcrossed
R6624 T21651 T21649 advmod then,backcrossed
R6625 T21652 T21649 prep to,backcrossed
R6626 T21653 T21654 compound HG,females
R6627 T21654 T21652 pobj females,to
R6628 T21655 T21649 punct .,backcrossed
R6629 T21657 T21658 det All,males
R663 T3109 T3110 punct -,16
R6630 T21658 T21677 nsubjpass males,genotyped
R6631 T21659 T21658 nmod agouti,males
R6632 T21660 T21661 punct (,located
R6633 T21661 T21658 parataxis located,males
R6634 T21662 T21663 det the,locus
R6635 T21663 T21661 nsubjpass locus,located
R6636 T21664 T21663 amod dominant,locus
R6637 T21665 T21666 amod nonagouti,a
R6638 T21666 T21663 amod a,locus
R6639 T21667 T21666 punct (,a
R664 T3132 T3129 punct /,Socs2
R6640 T21668 T21663 punct ),locus
R6641 T21669 T21661 auxpass is,located
R6642 T21670 T21661 prep at,located
R6643 T21671 T21672 nummod 154.8,Mbp
R6644 T21672 T21670 pobj Mbp,at
R6645 T21673 T21661 prep on,located
R6646 T21674 T21673 pobj MMU2,on
R6647 T21675 T21661 punct ),located
R6648 T21676 T21658 compound N2,males
R6649 T21678 T21677 auxpass were,genotyped
R665 T3133 T3129 punct -,Socs2
R6650 T21679 T21677 prep for,genotyped
R6651 T21680 T21681 nummod 79,markers
R6652 T21681 T21679 pobj markers,for
R6653 T21682 T21681 compound microsatellite,markers
R6654 T21683 T21684 punct (,File
R6655 T21684 T21677 parataxis File,genotyped
R6656 T21685 T21684 amod Additional,File
R6657 T21686 T21684 nummod 1,File
R6658 T21687 T21684 punct ),File
R6659 T21688 T21677 punct .,genotyped
R666 T3110 T3108 prep 16,14
R6660 T21690 T21691 det These,markers
R6661 T21691 T21692 nsubjpass markers,spaced
R6662 T21693 T21692 auxpass were,spaced
R6663 T21694 T21692 advmod evenly,spaced
R6664 T21695 T21692 prep across,spaced
R6665 T21696 T21697 det the,genome
R6666 T21697 T21695 pobj genome,across
R6667 T21698 T21692 punct ", ",spaced
R6668 T21699 T21700 advmod except,in
R6669 T21700 T21692 prep in,spaced
R667 T3134 T3135 dep which,shared
R6670 T21701 T21700 pobj regions,in
R6671 T21702 T21703 advmod previously,identified
R6672 T21703 T21701 acl identified,regions
R6673 T21704 T21703 prep as,identified
R6674 T21705 T21704 pcomp harboring,as
R6675 T21706 T21705 dobj QTL,harboring
R6676 T21707 T21708 punct [,1
R6677 T21708 T21705 parataxis 1,harboring
R6678 T21709 T21708 punct ],1
R6679 T21710 T21701 punct ", ",regions
R668 T3111 T3108 punct ],14
R6680 T21711 T21712 dep which,screened
R6681 T21712 T21701 relcl screened,regions
R6682 T21713 T21712 auxpass were,screened
R6683 T21714 T21715 advmod more,densely
R6684 T21715 T21712 advmod densely,screened
R6685 T21716 T21692 punct .,spaced
R6686 T21718 T21719 det The,male
R6687 T21719 T21725 nsubjpass male,selected
R6688 T21720 T21719 punct """",male
R6689 T21721 T21719 amod best,male
R669 T3112 T3079 punct .,is
R6690 T21722 T21719 punct """",male
R6691 T21723 T21724 compound N2,agouti
R6692 T21724 T21719 compound agouti,male
R6693 T21726 T21719 prep with,male
R6694 T21727 T21728 det the,level
R6695 T21728 T21726 pobj level,with
R6696 T21729 T21728 amod lowest,level
R6697 T21730 T21728 prep of,level
R6698 T21731 T21732 npadvmod genome,wide
R6699 T21732 T21734 amod wide,heterozygosity
R67 T649 T648 prep of,panels
R670 T3135 T3126 relcl shared,mouse
R6700 T21733 T21732 punct -,wide
R6701 T21734 T21730 pobj heterozygosity,of
R6702 T21735 T21734 amod unwanted,heterozygosity
R6703 T21736 T21737 mark while,maintaining
R6704 T21737 T21725 advcl maintaining,selected
R6705 T21738 T21739 compound CAST,alleles
R6706 T21739 T21737 dobj alleles,maintaining
R6707 T21740 T21739 prep for,alleles
R6708 T21741 T21742 det all,markers
R6709 T21742 T21740 pobj markers,for
R671 T3136 T3137 det a,number
R6710 T21743 T21742 compound MMU2,markers
R6711 T21744 T21725 auxpass was,selected
R6712 T21745 T21725 prep for,selected
R6713 T21746 T21745 pobj breeding,for
R6714 T21747 T21725 punct .,selected
R6715 T21749 T21750 det This,scheme
R6716 T21750 T21752 nsubjpass scheme,used
R6717 T21751 T21750 compound selection,scheme
R6718 T21753 T21752 auxpass was,used
R6719 T21754 T21752 prep at,used
R672 T3137 T3135 dobj number,shared
R6720 T21755 T21756 det each,generation
R6721 T21756 T21754 pobj generation,at
R6722 T21757 T21758 mark until,identified
R6723 T21758 T21752 advcl identified,used
R6724 T21759 T21760 det a,male
R6725 T21760 T21758 nsubjpass male,identified
R6726 T21761 T21760 compound N4,male
R6727 T21762 T21758 auxpass was,identified
R6728 T21763 T21758 prep as,identified
R6729 T21764 T21765 amod homozygous,HG
R673 T3138 T3137 prep of,number
R6730 T21765 T21763 pobj HG,as
R6731 T21766 T21765 prep for,HG
R6732 T21767 T21768 det all,markers
R6733 T21768 T21766 pobj markers,for
R6734 T21769 T21768 acl typed,markers
R6735 T21770 T21769 prep outside,typed
R6736 T21771 T21770 pobj MMU2,outside
R6737 T21772 T21752 punct .,used
R6738 T21774 T21775 prep After,identified
R6739 T21776 T21777 det an,backcross
R674 T3220 T3219 prep of,basis
R6740 T21777 T21774 pobj backcross,After
R6741 T21778 T21777 amod additional,backcross
R6742 T21779 T21777 prep to,backcross
R6743 T21780 T21781 compound HG,females
R6744 T21781 T21779 pobj females,to
R6745 T21782 T21775 punct ", ",identified
R6746 T21783 T21784 amod recombinant,males
R6747 T21784 T21775 nsubjpass males,identified
R6748 T21785 T21775 auxpass were,identified
R6749 T21786 T21775 advcl providing,identified
R675 T3221 T3222 det these,interactions
R6750 T21787 T21788 det the,foundation
R6751 T21788 T21786 dobj foundation,providing
R6752 T21789 T21788 prep for,foundation
R6753 T21790 T21791 det the,regions
R6754 T21791 T21789 pobj regions,for
R6755 T21792 T21791 nummod four,regions
R6756 T21793 T21791 amod overlapping,regions
R6757 T21794 T21791 compound donor,regions
R6758 T21795 T21775 punct .,identified
R6759 T21797 T21798 amod Selected,males
R676 T3139 T3138 pobj phenotypes,of
R6760 T21798 T21800 nsubjpass males,backcrossed
R6761 T21799 T21798 amod recombinant,males
R6762 T21801 T21800 auxpass were,backcrossed
R6763 T21802 T21800 advmod then,backcrossed
R6764 T21803 T21800 prep to,backcrossed
R6765 T21804 T21805 preconj both,B6
R6766 T21805 T21806 nmod B6,females
R6767 T21806 T21803 pobj females,to
R6768 T21807 T21805 cc and,B6
R6769 T21808 T21805 conj HG,B6
R677 T3222 T3220 pobj interactions,of
R6770 T21809 T21810 aux to,create
R6771 T21810 T21800 advcl create,backcrossed
R6772 T21811 T21810 dobj strains,create
R6773 T21812 T21811 punct ", ",strains
R6774 T21813 T21814 dep which,were
R6775 T21814 T21811 relcl were,strains
R6776 T21815 T21816 npadvmod B6,congenic
R6777 T21816 T21814 acomp congenic,were
R6778 T21817 T21818 punct (,+
R6779 T21818 T21815 punct +,B6
R678 T3223 T3217 punct ", ",forms
R6780 T21819 T21818 punct +,+
R6781 T21820 T21818 punct /,+
R6782 T21821 T21818 punct ),+
R6783 T21822 T21815 cc or,B6
R6784 T21823 T21815 conj HG,B6
R6785 T21824 T21825 punct (,hg
R6786 T21825 T21823 parataxis hg,HG
R6787 T21826 T21825 compound hg,hg
R6788 T21827 T21825 punct /,hg
R6789 T21828 T21825 punct ),hg
R679 T3224 T3217 advcl implying,forms
R6790 T21829 T21815 cc and,B6
R6791 T21830 T21815 conj heterozygous,B6
R6792 T21831 T21800 punct .,backcrossed
R6793 T21833 T21834 det These,mice
R6794 T21834 T21835 nsubjpass mice,intermated
R6795 T21836 T21835 auxpass were,intermated
R6796 T21837 T21838 aux to,produce
R6797 T21838 T21835 advcl produce,intermated
R6798 T21839 T21840 amod homozygous,founders
R6799 T21840 T21838 dobj founders,produce
R68 T650 T651 npadvmod speed,congenic
R680 T3140 T3137 prep in,number
R6800 T21841 T21838 prep for,produce
R6801 T21842 T21843 det each,strain
R6802 T21843 T21841 pobj strain,for
R6803 T21844 T21835 punct .,intermated
R6804 T21846 T21847 det This,scheme
R6805 T21847 T21850 nsubj scheme,created
R6806 T21848 T21847 amod novel,scheme
R6807 T21849 T21847 amod breeding,scheme
R6808 T21851 T21852 nummod four,congenics
R6809 T21852 T21850 dobj congenics,created
R681 T3225 T3226 mark that,are
R6810 T21853 T21852 amod identical,congenics
R6811 T21854 T21852 compound founder,congenics
R6812 T21855 T21852 prep on,congenics
R6813 T21856 T21857 nummod two,backgrounds
R6814 T21857 T21855 pobj backgrounds,on
R6815 T21858 T21857 appos B6,backgrounds
R6816 T21859 T21860 punct (,+
R6817 T21860 T21858 punct +,B6
R6818 T21861 T21860 punct +,+
R6819 T21862 T21860 punct /,+
R682 T3226 T3224 ccomp are,implying
R6820 T21863 T21860 punct ),+
R6821 T21864 T21858 cc and,B6
R6822 T21865 T21858 conj HG,B6
R6823 T21866 T21867 punct (,hg
R6824 T21867 T21865 parataxis hg,HG
R6825 T21868 T21867 compound hg,hg
R6826 T21869 T21867 punct /,hg
R6827 T21870 T21867 punct ),hg
R6828 T21871 T21857 punct ", ",backgrounds
R6829 T21872 T21873 dep which,formed
R683 T3141 T3140 pobj common,in
R6830 T21873 T21857 relcl formed,backgrounds
R6831 T21874 T21875 det the,basis
R6832 T21875 T21873 dobj basis,formed
R6833 T21876 T21875 prep for,basis
R6834 T21877 T21878 poss our,examination
R6835 T21878 T21876 pobj examination,for
R6836 T21879 T21878 prep of,examination
R6837 T21880 T21879 pobj interactions,of
R6838 T21881 T21880 acl caused,interactions
R6839 T21882 T21881 agent by,caused
R684 T3227 T3228 det the,gene
R6840 T21883 T21884 det the,presence
R6841 T21884 T21882 pobj presence,by
R6842 T21885 T21884 prep of,presence
R6843 T21886 T21887 det the,deletion
R6844 T21887 T21885 pobj deletion,of
R6845 T21888 T21887 compound hg,deletion
R6846 T21889 T21850 punct .,created
R6847 T21891 T21892 nmod MMU2,strains
R6848 T21892 T21895 nsubjpass strains,maintained
R6849 T21893 T21894 npadvmod speed,congenic
R685 T3228 T3226 nsubj gene,are
R6850 T21894 T21892 amod congenic,strains
R6851 T21896 T21895 auxpass were,maintained
R6852 T21897 T21895 prep through,maintained
R6853 T21898 T21899 compound brother,sister
R6854 T21899 T21901 compound sister,mating
R6855 T21900 T21899 punct -,sister
R6856 T21901 T21897 pobj mating,through
R6857 T21902 T21895 punct .,maintained
R6858 T21904 T21905 advmod Once,stabilized
R6859 T21905 T21909 advcl stabilized,used
R686 T3229 T3228 amod known,gene
R6860 T21906 T21907 det each,congenic
R6861 T21907 T21905 nsubjpass congenic,stabilized
R6862 T21908 T21905 auxpass was,stabilized
R6863 T21910 T21909 punct ", ",used
R6864 T21911 T21912 nummod 20,markers
R6865 T21912 T21909 nsubjpass markers,used
R6866 T21913 T21912 amod additional,markers
R6867 T21914 T21912 compound microsatellite,markers
R6868 T21915 T21909 auxpass were,used
R6869 T21916 T21917 aux to,refine
R687 T3230 T3228 cc and,gene
R6870 T21917 T21909 advcl refine,used
R6871 T21918 T21919 det the,position
R6872 T21919 T21917 dobj position,refine
R6873 T21920 T21919 prep of,position
R6874 T21921 T21922 det each,point
R6875 T21922 T21920 pobj point,of
R6876 T21923 T21922 amod congenic,point
R6877 T21924 T21922 amod recombinant,point
R6878 T21925 T21922 compound end,point
R6879 T21926 T21927 punct (,File
R688 T3142 T3141 prep with,common
R6880 T21927 T21909 parataxis File,used
R6881 T21928 T21927 amod Additional,File
R6882 T21929 T21927 nummod 2,File
R6883 T21930 T21927 punct ),File
R6884 T21931 T21909 punct .,used
R6885 T22599 T22598 prep of,Development
R6886 T22600 T22601 nmod HG.CAST,strains
R6887 T22601 T22599 pobj strains,of
R6888 T22602 T22603 npadvmod speed,congenic
R6889 T22603 T22601 amod congenic,strains
R689 T3231 T3232 poss its,modifiers
R6890 T22604 T22601 prep for,strains
R6891 T22605 T22606 nmod MMU,1
R6892 T22606 T22604 pobj 1,for
R6893 T22607 T22606 punct ", ",1
R6894 T22608 T22606 conj 5,1
R6895 T22609 T22608 punct ", ",5
R6896 T22610 T22608 conj 8,5
R6897 T22611 T22610 punct ", ",8
R6898 T22612 T22610 conj 9,8
R6899 T22613 T22612 punct ", ",9
R69 T651 T652 amod congenic,strains
R690 T3232 T3228 conj modifiers,gene
R6900 T22614 T22612 conj 11,9
R6901 T22615 T22614 cc and,11
R6902 T22616 T22614 conj 17,11
R6903 T22618 T22619 det All,males
R6904 T22619 T22622 nsubjpass males,genotyped
R6905 T22620 T22619 amod black,males
R6906 T22621 T22619 compound N2,males
R6907 T22623 T22619 prep from,males
R6908 T22624 T22625 det the,crosses
R6909 T22625 T22623 pobj crosses,from
R691 T3143 T3142 pobj HG,with
R6910 T22626 T22625 amod first,crosses
R6911 T22627 T22625 nummod two,crosses
R6912 T22628 T22625 acl described,crosses
R6913 T22629 T22628 advmod above,described
R6914 T22630 T22622 auxpass were,genotyped
R6915 T22631 T22622 prep for,genotyped
R6916 T22632 T22633 nummod 12,markers
R6917 T22633 T22631 pobj markers,for
R6918 T22634 T22633 punct (,markers
R6919 T22635 T22633 appos D1Mit432,markers
R692 T3233 T3226 attr members,are
R6920 T22636 T22635 punct ", ",D1Mit432
R6921 T22637 T22638 punct -,480
R6922 T22638 T22635 conj 480,D1Mit432
R6923 T22639 T22638 punct ", ",480
R6924 T22640 T22638 conj D5Mit353,480
R6925 T22641 T22640 punct ", ",D5Mit353
R6926 T22642 T22643 punct -,311
R6927 T22643 T22640 conj 311,D5Mit353
R6928 T22644 T22643 punct ", ",311
R6929 T22645 T22643 conj D9Mit60,311
R693 T3234 T3233 prep of,members
R6930 T22646 T22645 punct ", ",D9Mit60
R6931 T22647 T22648 punct -,262
R6932 T22648 T22645 conj 262,D9Mit60
R6933 T22649 T22648 punct ", ",262
R6934 T22650 T22648 conj D11Mit5,262
R6935 T22651 T22650 punct ", ",D11Mit5
R6936 T22652 T22653 punct -,67
R6937 T22653 T22650 conj 67,D11Mit5
R6938 T22654 T22653 punct ", ",67
R6939 T22655 T22653 conj D8Mit234,67
R694 T3144 T3137 punct ", ",number
R6940 T22656 T22655 punct ", ",D8Mit234
R6941 T22657 T22658 punct -,211
R6942 T22658 T22655 conj 211,D8Mit234
R6943 T22659 T22658 cc and,211
R6944 T22660 T22658 conj D17Mit28,211
R6945 T22661 T22660 cc and,D17Mit28
R6946 T22662 T22663 punct -,142
R6947 T22663 T22660 conj 142,D17Mit28
R6948 T22664 T22633 punct ),markers
R6949 T22665 T22633 punct ", ",markers
R695 T3235 T3236 det the,pathway
R6950 T22666 T22633 appos two,markers
R6951 T22667 T22666 acl spanning,two
R6952 T22668 T22667 dobj each,spanning
R6953 T22669 T22668 prep of,each
R6954 T22670 T22671 det the,regions
R6955 T22671 T22669 pobj regions,of
R6956 T22672 T22671 nummod six,regions
R6957 T22673 T22674 npadvmod QTL,harboring
R6958 T22674 T22671 amod harboring,regions
R6959 T22675 T22671 punct (,regions
R696 T3236 T3234 pobj pathway,of
R6960 T22676 T22677 nmod MMU,1
R6961 T22677 T22671 appos 1,regions
R6962 T22678 T22677 punct ", ",1
R6963 T22679 T22677 conj 5,1
R6964 T22680 T22679 punct ", ",5
R6965 T22681 T22679 conj 8,5
R6966 T22682 T22681 punct ", ",8
R6967 T22683 T22681 conj 9,8
R6968 T22684 T22683 punct ", ",9
R6969 T22685 T22683 conj 11,9
R697 T3237 T3236 amod same,pathway
R6970 T22686 T22685 cc and,11
R6971 T22687 T22685 conj 17,11
R6972 T22688 T22689 punct ;,Table
R6973 T22689 T22622 parataxis Table,genotyped
R6974 T22690 T22689 nummod 1,Table
R6975 T22691 T22689 cc and,Table
R6976 T22692 T22693 amod Additional,File
R6977 T22693 T22689 conj File,Table
R6978 T22694 T22693 nummod 1,File
R6979 T22695 T22689 punct ),Table
R698 T3238 T3236 amod biochemical,pathway
R6980 T22696 T22622 punct .,genotyped
R6981 T22698 T22699 nsubjpass Markers,selected
R6982 T22700 T22699 auxpass were,selected
R6983 T22701 T22702 aux to,capture
R6984 T22702 T22699 advcl capture,selected
R6985 T22703 T22702 punct ", ",capture
R6986 T22704 T22702 prep at,capture
R6987 T22705 T22706 det a,minimum
R6988 T22706 T22704 pobj minimum,at
R6989 T22707 T22702 punct ", ",capture
R699 T3239 T3238 cc or,biochemical
R6990 T22708 T22709 det the,interval
R6991 T22709 T22702 dobj interval,capture
R6992 T22710 T22711 nummod 2,LOD
R6993 T22711 T22709 compound LOD,interval
R6994 T22712 T22711 punct -,LOD
R6995 T22713 T22709 compound support,interval
R6996 T22714 T22699 punct .,selected
R6997 T22716 T22717 nummod Two,males
R6998 T22717 T22719 nsubjpass males,selected
R6999 T22718 T22717 compound N2,males
R7 T582 T579 conj obesity,growth
R70 T652 T649 pobj strains,of
R700 T3240 T3238 conj metabolic,biochemical
R7000 T22720 T22719 auxpass were,selected
R7001 T22721 T22722 aux to,propagate
R7002 T22722 T22719 xcomp propagate,selected
R7003 T22723 T22724 det the,generation
R7004 T22724 T22722 dobj generation,propagate
R7005 T22725 T22724 compound N3,generation
R7006 T22726 T22719 punct ;,selected
R7007 T22727 T22719 dobj one,selected
R7008 T22728 T22727 amod heterozygous,one
R7009 T22729 T22728 prep for,heterozygous
R701 T3241 T3217 punct .,forms
R7010 T22730 T22729 pobj QTL,for
R7011 T22731 T22730 prep on,QTL
R7012 T22732 T22733 nmod MMU,1
R7013 T22733 T22731 pobj 1,on
R7014 T22734 T22733 cc and,1
R7015 T22735 T22733 conj 9,1
R7016 T22736 T22727 cc and,one
R7017 T22737 T22738 det the,other
R7018 T22738 T22727 conj other,one
R7019 T22739 T22738 amod heterozygous,other
R702 T3145 T3137 prep including,number
R7020 T22740 T22739 prep for,heterozygous
R7021 T22741 T22740 pobj QTL,for
R7022 T22742 T22741 prep on,QTL
R7023 T22743 T22744 nmod MMU,5
R7024 T22744 T22742 pobj 5,on
R7025 T22745 T22744 punct ", ",5
R7026 T22746 T22744 conj 8,5
R7027 T22747 T22746 punct ", ",8
R7028 T22748 T22746 conj 11,8
R7029 T22749 T22748 cc and,11
R703 T3243 T3244 amod Different,backgrounds
R7030 T22750 T22748 conj 17,11
R7031 T22751 T22752 punct (,Figure
R7032 T22752 T22719 parataxis Figure,selected
R7033 T22753 T22752 nummod 1,Figure
R7034 T22754 T22752 punct ),Figure
R7035 T22755 T22719 punct .,selected
R7036 T22757 T22758 det Both,males
R7037 T22758 T22759 nsubj males,were
R7038 T22760 T22759 acomp homozygous,were
R7039 T22761 T22760 prep for,homozygous
R704 T3244 T3246 nsubjpass backgrounds,shown
R7040 T22762 T22763 compound HG,alleles
R7041 T22763 T22761 pobj alleles,for
R7042 T22764 T22759 prep at,were
R7043 T22765 T22766 det all,QTL
R7044 T22766 T22764 pobj QTL,at
R7045 T22767 T22766 amod other,QTL
R7046 T22768 T22766 amod known,QTL
R7047 T22769 T22759 punct .,were
R7048 T22771 T22772 det These,males
R7049 T22772 T22773 nsubjpass males,backcrossed
R705 T3245 T3244 amod genetic,backgrounds
R7050 T22774 T22773 auxpass were,backcrossed
R7051 T22775 T22773 prep to,backcrossed
R7052 T22776 T22777 compound HG,females
R7053 T22777 T22775 pobj females,to
R7054 T22778 T22773 cc and,backcrossed
R7055 T22779 T22780 nsubjpass two,selected
R7056 T22780 T22773 conj selected,backcrossed
R7057 T22781 T22779 prep of,two
R7058 T22782 T22783 det the,males
R7059 T22783 T22781 pobj males,of
R706 T3146 T3145 pobj gigantism,including
R7060 T22784 T22783 amod resulting,males
R7061 T22785 T22783 compound N3,males
R7062 T22786 T22783 acl inheriting,males
R7063 T22787 T22788 det the,sets
R7064 T22788 T22786 dobj sets,inheriting
R7065 T22789 T22788 amod same,sets
R7066 T22790 T22788 prep of,sets
R7067 T22791 T22790 pobj QTL,of
R7068 T22792 T22788 prep as,sets
R7069 T22793 T22794 poss their,sire
R707 T3247 T3246 aux have,shown
R7070 T22794 T22792 pobj sire,as
R7071 T22795 T22780 auxpass were,selected
R7072 T22796 T22780 prep for,selected
R7073 T22797 T22796 pobj breeding,for
R7074 T22798 T22780 punct .,selected
R7075 T22800 T22801 det These,males
R7076 T22801 T22802 nsubjpass males,backcrossed
R7077 T22803 T22802 auxpass were,backcrossed
R7078 T22804 T22802 advmod subsequently,backcrossed
R7079 T22805 T22802 prep to,backcrossed
R708 T3248 T3246 auxpass been,shown
R7080 T22806 T22807 compound HG,females
R7081 T22807 T22805 pobj females,to
R7082 T22808 T22802 cc and,backcrossed
R7083 T22809 T22810 nummod three,males
R7084 T22810 T22812 nsubjpass males,identified
R7085 T22811 T22810 compound N4,males
R7086 T22812 T22802 conj identified,backcrossed
R7087 T22813 T22812 auxpass were,identified
R7088 T22814 T22812 acomp heterozygous,identified
R7089 T22815 T22814 prep for,heterozygous
R709 T3147 T3148 punct [,17
R7090 T22816 T22817 det the,regions
R7091 T22817 T22815 pobj regions,for
R7092 T22818 T22817 amod following,regions
R7093 T22819 T22817 punct : ,regions
R7094 T22820 T22821 meta 1,1
R7095 T22821 T22817 appos 1,regions
R7096 T22822 T22820 punct ),1
R7097 T22823 T22821 nmod MMU,1
R7098 T22824 T22821 cc and,1
R7099 T22825 T22821 conj 9,1
R71 T653 T640 auxpass were,developed
R710 T3249 T3250 aux to,modify
R7100 T22826 T22821 punct ;,1
R7101 T22827 T22828 meta 2,5
R7102 T22828 T22821 appos 5,1
R7103 T22829 T22827 punct ),2
R7104 T22830 T22828 nmod MMU,5
R7105 T22831 T22828 cc and,5
R7106 T22832 T22828 conj 11,5
R7107 T22833 T22821 punct ;,1
R7108 T22834 T22835 meta 3,8
R7109 T22835 T22821 appos 8,1
R711 T3148 T3116 parataxis 17,confirmed
R7110 T22836 T22834 punct ),3
R7111 T22837 T22835 nmod MMU,8
R7112 T22838 T22835 punct ", ",8
R7113 T22839 T22835 conj 11,8
R7114 T22840 T22839 cc and,11
R7115 T22841 T22839 conj 17,11
R7116 T22842 T22843 punct (,Figure
R7117 T22843 T22812 parataxis Figure,identified
R7118 T22844 T22843 nummod 1,Figure
R7119 T22845 T22843 punct ),Figure
R712 T3250 T3246 xcomp modify,shown
R7120 T22846 T22812 punct .,identified
R7121 T22848 T22849 advcl Starting,selected
R7122 T22850 T22848 prep at,Starting
R7123 T22851 T22850 pobj N4,at
R7124 T22852 T22848 cc and,Starting
R7125 T22853 T22848 conj continuing,Starting
R7126 T22854 T22853 prep through,continuing
R7127 T22855 T22854 pobj N6,through
R7128 T22856 T22849 punct ", ",selected
R7129 T22857 T22858 det the,male
R713 T3251 T3252 det the,effects
R7130 T22858 T22849 nsubjpass male,selected
R7131 T22859 T22858 punct """",male
R7132 T22860 T22858 amod best,male
R7133 T22861 T22858 punct """",male
R7134 T22862 T22858 prep with,male
R7135 T22863 T22864 det the,percent
R7136 T22864 T22862 pobj percent,with
R7137 T22865 T22864 amod lowest,percent
R7138 T22866 T22864 prep of,percent
R7139 T22867 T22868 amod unwanted,alleles
R714 T3252 T3250 dobj effects,modify
R7140 T22868 T22866 pobj alleles,of
R7141 T22869 T22868 compound donor,alleles
R7142 T22870 T22849 auxpass was,selected
R7143 T22871 T22849 prep after,selected
R7144 T22872 T22871 pcomp performing,after
R7145 T22873 T22874 det a,scan
R7146 T22874 T22872 dobj scan,performing
R7147 T22875 T22874 compound genome,scan
R7148 T22876 T22872 advcl using,performing
R7149 T22877 T22878 det the,markers
R715 T3149 T3148 punct ],17
R7150 T22878 T22876 dobj markers,using
R7151 T22879 T22878 amod remaining,markers
R7152 T22880 T22878 nummod 67,markers
R7153 T22881 T22882 npadvmod genome,wide
R7154 T22882 T22878 amod wide,markers
R7155 T22883 T22882 punct -,wide
R7156 T22884 T22885 punct (,markers
R7157 T22885 T22878 parataxis markers,markers
R7158 T22886 T22885 nummod 79,markers
R7159 T22887 T22885 amod total,markers
R716 T3253 T3254 npadvmod growth,enhancing
R7160 T22888 T22885 cc minus,markers
R7161 T22889 T22890 det the,markers
R7162 T22890 T22885 conj markers,markers
R7163 T22891 T22890 nummod 12,markers
R7164 T22892 T22890 acl genotyped,markers
R7165 T22893 T22892 prep in,genotyped
R7166 T22894 T22895 det the,backcrosses
R7167 T22895 T22893 pobj backcrosses,in
R7168 T22896 T22895 amod first,backcrosses
R7169 T22897 T22895 nummod two,backcrosses
R717 T3254 T3252 amod enhancing,effects
R7170 T22898 T22895 acl spanning,backcrosses
R7171 T22899 T22900 det the,intervals
R7172 T22900 T22898 dobj intervals,spanning
R7173 T22901 T22900 amod know,intervals
R7174 T22902 T22900 compound QTL,intervals
R7175 T22903 T22885 punct ),markers
R7176 T22904 T22849 punct .,selected
R7177 T22906 T22907 prep At,created
R7178 T22908 T22906 pobj N5,At
R7179 T22909 T22910 det a,strain
R718 T3255 T3254 punct -,enhancing
R7180 T22910 T22907 nsubjpass strain,created
R7181 T22911 T22910 amod distinct,strain
R7182 T22912 T22907 auxpass was,created
R7183 T22913 T22907 prep for,created
R7184 T22914 T22913 pobj each,for
R7185 T22915 T22914 prep of,each
R7186 T22916 T22917 det the,regions
R7187 T22917 T22915 pobj regions,of
R7188 T22918 T22917 nummod six,regions
R7189 T22919 T22917 amod individual,regions
R719 T3150 T3116 punct .,confirmed
R7190 T22920 T22917 compound donor,regions
R7191 T22921 T22907 cc and,created
R7192 T22922 T22923 amod heterozygous,mice
R7193 T22923 T22924 nsubjpass mice,intermated
R7194 T22924 T22907 conj intermated,created
R7195 T22925 T22924 auxpass were,intermated
R7196 T22926 T22927 punct (,Figure
R7197 T22927 T22907 parataxis Figure,created
R7198 T22928 T22927 nummod 1,Figure
R7199 T22929 T22927 punct ),Figure
R72 T654 T640 prep by,developed
R720 T3256 T3252 prep of,effects
R7200 T22930 T22907 punct .,created
R7201 T22932 T22933 amod Homozygous,strains
R7202 T22933 T22937 nsubjpass strains,maintained
R7203 T22934 T22933 nmod HG.CAST,strains
R7204 T22935 T22936 npadvmod speed,congenic
R7205 T22936 T22933 amod congenic,strains
R7206 T22938 T22937 auxpass were,maintained
R7207 T22939 T22937 prep through,maintained
R7208 T22940 T22941 compound brother,sister
R7209 T22941 T22943 compound sister,mating
R721 T3257 T3256 pobj hg,of
R7210 T22942 T22941 punct -,sister
R7211 T22943 T22939 pobj mating,through
R7212 T22944 T22937 punct .,maintained
R7213 T22946 T22947 mark Once,stabilized
R7214 T22947 T22951 advcl stabilized,used
R7215 T22948 T22949 det each,congenic
R7216 T22949 T22947 nsubjpass congenic,stabilized
R7217 T22950 T22947 auxpass was,stabilized
R7218 T22952 T22951 punct ", ",used
R7219 T22953 T22954 nummod 19,markers
R722 T3258 T3259 punct [,22
R7220 T22954 T22951 nsubjpass markers,used
R7221 T22955 T22954 amod additional,markers
R7222 T22956 T22954 compound microsatellite,markers
R7223 T22957 T22951 auxpass were,used
R7224 T22958 T22959 aux to,refine
R7225 T22959 T22951 advcl refine,used
R7226 T22960 T22961 det the,position
R7227 T22961 T22959 dobj position,refine
R7228 T22962 T22961 prep of,position
R7229 T22963 T22964 det each,point
R723 T3259 T3246 parataxis 22,shown
R7230 T22964 T22962 pobj point,of
R7231 T22965 T22964 amod congenic,point
R7232 T22966 T22964 amod recombinant,point
R7233 T22967 T22964 compound end,point
R7234 T22968 T22969 punct (,File
R7235 T22969 T22951 parataxis File,used
R7236 T22970 T22969 amod Additional,File
R7237 T22971 T22969 nummod 2,File
R7238 T22972 T22969 punct ),File
R7239 T22973 T22951 punct .,used
R724 T3152 T3153 nsubjpass QTL,referred
R7240 T23421 T23420 prep of,Development
R7241 T23422 T23423 nmod B6.CASTC,strains
R7242 T23423 T23421 pobj strains,of
R7243 T23424 T23422 cc and,B6.CASTC
R7244 T23425 T23422 conj HG.CASTC,B6.CASTC
R7245 T23426 T23423 compound control,strains
R7246 T23428 T23429 nsubj HG,is
R7247 T23429 T23430 ccomp is,be
R7248 T23431 T23432 det a,strain
R7249 T23432 T23429 attr strain,is
R725 T3260 T3259 nummod 15,22
R7250 T23433 T23434 prep in,introgressed
R7251 T23434 T23432 relcl introgressed,strain
R7252 T23435 T23433 pobj which,in
R7253 T23436 T23437 det the,deletion
R7254 T23437 T23434 nsubjpass deletion,introgressed
R7255 T23438 T23437 compound hg,deletion
R7256 T23439 T23434 aux has,introgressed
R7257 T23440 T23434 auxpass been,introgressed
R7258 T23441 T23434 prep onto,introgressed
R7259 T23442 T23443 det a,background
R726 T3261 T3259 punct ",",22
R7260 T23443 T23441 pobj background,onto
R7261 T23444 T23443 compound B6,background
R7262 T23445 T23430 punct ", ",be
R7263 T23446 T23430 advmod therefore,be
R7264 T23447 T23448 det the,differences
R7265 T23448 T23430 nsubj differences,be
R7266 T23449 T23448 amod only,differences
R7267 T23450 T23448 amod genetic,differences
R7268 T23451 T23448 prep between,differences
R7269 T23452 T23453 det the,strains
R727 T3262 T3259 punct ],22
R7270 T23453 T23451 pobj strains,between
R7271 T23454 T23430 aux would,be
R7272 T23455 T23456 det the,locus
R7273 T23456 T23430 attr locus,be
R7274 T23457 T23456 compound hg,locus
R7275 T23458 T23456 punct ", ",locus
R7276 T23459 T23460 advmod tightly,linked
R7277 T23460 T23461 amod linked,alleles
R7278 T23461 T23456 conj alleles,locus
R7279 T23462 T23461 prep from,alleles
R728 T3154 T3155 dep which,alter
R7280 T23463 T23464 det the,strain
R7281 T23464 T23462 pobj strain,from
R7282 T23465 T23464 amod outbred,strain
R7283 T23466 T23467 prep on,arose
R7284 T23467 T23464 relcl arose,strain
R7285 T23468 T23466 pobj which,on
R7286 T23469 T23467 nsubj hg,arose
R7287 T23470 T23461 cc and,alleles
R7288 T23471 T23472 amod contaminating,alleles
R7289 T23472 T23461 conj alleles,alleles
R729 T3263 T3246 punct .,shown
R7290 T23473 T23472 acl remaining,alleles
R7291 T23474 T23473 prep after,remaining
R7292 T23475 T23476 det the,backcrosses
R7293 T23476 T23474 pobj backcrosses,after
R7294 T23477 T23476 nummod nine,backcrosses
R7295 T23478 T23473 cc and,remaining
R7296 T23479 T23473 conj fixed,remaining
R7297 T23480 T23479 prep during,fixed
R7298 T23481 T23480 pobj inbreeding,during
R7299 T23482 T23430 punct .,be
R73 T655 T654 pcomp introgressing,by
R730 T3265 T3266 mark Since,is
R7300 T23484 T23485 advmod Instead,of
R7301 T23485 T23486 prep of,choose
R7302 T23487 T23485 pcomp using,of
R7303 T23488 T23489 amod parental,strains
R7304 T23489 T23487 dobj strains,using
R7305 T23490 T23489 nmod B6,strains
R7306 T23491 T23490 cc and,B6
R7307 T23492 T23490 conj HG,B6
R7308 T23493 T23487 prep as,using
R7309 T23494 T23493 pobj controls,as
R731 T3266 T3272 advcl is,is
R7310 T23495 T23494 prep for,controls
R7311 T23496 T23497 amod phenotypic,comparisons
R7312 T23497 T23495 pobj comparisons,for
R7313 T23498 T23497 prep with,comparisons
R7314 T23499 T23500 det each,speed
R7315 T23500 T23498 pobj speed,with
R7316 T23501 T23500 amod congenic,speed
R7317 T23502 T23486 punct ", ",choose
R7318 T23503 T23486 nsubj we,choose
R7319 T23504 T23505 aux to,develop
R732 T3267 T3268 det the,function
R7320 T23505 T23486 xcomp develop,choose
R7321 T23506 T23507 amod independent,strains
R7322 T23507 T23505 dobj strains,develop
R7323 T23508 T23507 compound control,strains
R7324 T23509 T23507 acl originating,strains
R7325 T23510 T23509 prep from,originating
R7326 T23511 T23512 det the,cross
R7327 T23512 T23510 pobj cross,from
R7328 T23513 T23512 amod same,cross
R7329 T23514 T23512 prep as,cross
R733 T3155 T3152 relcl alter,QTL
R7330 T23515 T23516 det the,panels
R7331 T23516 T23514 pobj panels,as
R7332 T23517 T23516 amod congenic,panels
R7333 T23518 T23486 punct .,choose
R7334 T23520 T23521 amod Separate,strains
R7335 T23521 T23533 nsubjpass strains,developed
R7336 T23522 T23523 nmod B6.CAST,control
R7337 T23523 T23521 nmod control,strains
R7338 T23524 T23523 punct (,control
R7339 T23525 T23523 appos B6C,control
R734 T3268 T3266 nsubj function,is
R7340 T23526 T23523 punct ),control
R7341 T23527 T23523 cc and,control
R7342 T23528 T23529 compound HG.CAST,control
R7343 T23529 T23523 conj control,control
R7344 T23530 T23529 punct (,control
R7345 T23531 T23529 appos HGC,control
R7346 T23532 T23521 punct ),strains
R7347 T23534 T23533 auxpass were,developed
R7348 T23535 T23533 advcl using,developed
R7349 T23536 T23535 dobj mice,using
R735 T3269 T3268 amod primary,function
R7350 T23537 T23536 prep from,mice
R7351 T23538 T23539 det the,experiment
R7352 T23539 T23537 pobj experiment,from
R7353 T23540 T23539 compound MMU2,experiment
R7354 T23541 T23533 punct .,developed
R7355 T23543 T23544 nsubjpass Mice,intermated
R7356 T23545 T23543 prep from,Mice
R7357 T23546 T23547 det the,backcross
R7358 T23547 T23545 pobj backcross,from
R7359 T23548 T23547 amod last,backcross
R736 T3270 T3268 prep of,function
R7360 T23549 T23543 acl inheriting,Mice
R7361 T23550 T23551 advmod only,alleles
R7362 T23551 T23549 dobj alleles,inheriting
R7363 T23552 T23551 nmod B6,alleles
R7364 T23553 T23552 cc or,B6
R7365 T23554 T23552 conj HG,B6
R7366 T23555 T23551 compound MMU2,alleles
R7367 T23556 T23549 prep at,inheriting
R7368 T23557 T23556 pobj markers,at
R7369 T23558 T23557 acl spanning,markers
R737 T3156 T3157 det the,effects
R7370 T23559 T23558 dobj MMU2,spanning
R7371 T23560 T23544 auxpass were,intermated
R7372 T23561 T23562 aux to,serve
R7373 T23562 T23544 advcl serve,intermated
R7374 T23563 T23562 prep as,serve
R7375 T23564 T23565 det the,basis
R7376 T23565 T23563 pobj basis,as
R7377 T23566 T23565 prep for,basis
R7378 T23567 T23568 det each,control
R7379 T23568 T23566 pobj control,for
R738 T3271 T3270 pobj Socs2,of
R7380 T23569 T23544 punct .,intermated
R7381 T23571 T23572 det Both,strains
R7382 T23572 T23574 nsubjpass strains,maintained
R7383 T23573 T23572 compound control,strains
R7384 T23575 T23574 auxpass were,maintained
R7385 T23576 T23574 advmod subsequently,maintained
R7386 T23577 T23574 prep through,maintained
R7387 T23578 T23579 compound brother,sister
R7388 T23579 T23581 compound sister,mating
R7389 T23580 T23579 punct -,sister
R739 T3157 T3155 dobj effects,alter
R7390 T23581 T23577 pobj mating,through
R7391 T23582 T23574 punct .,maintained
R7392 T23584 T23585 det The,strains
R7393 T23585 T23587 nsubj strains,were
R7394 T23586 T23585 compound control,strains
R7395 T23588 T23587 acomp coisogenic,were
R7396 T23589 T23588 prep with,coisogenic
R7397 T23590 T23591 det the,strain
R7398 T23591 T23589 pobj strain,with
R7399 T23592 T23591 amod parental,strain
R74 T656 T657 nmod CAST,EiJ
R740 T3273 T3274 aux to,regulate
R7400 T23593 T23591 nmod B6,strain
R7401 T23594 T23593 cc or,B6
R7402 T23595 T23593 conj HG,B6
R7403 T23596 T23587 prep with,were
R7404 T23597 T23598 det the,exception
R7405 T23598 T23596 pobj exception,with
R7406 T23599 T23598 prep of,exception
R7407 T23600 T23599 pobj mutations,of
R7408 T23601 T23602 dep that,arose
R7409 T23602 T23600 relcl arose,mutations
R741 T3274 T3266 xcomp regulate,is
R7410 T23603 T23602 prep during,arose
R7411 T23604 T23605 amod congenic,construction
R7412 T23605 T23603 pobj construction,during
R7413 T23606 T23600 cc and,mutations
R7414 T23607 T23608 det a,percentage
R7415 T23608 T23600 conj percentage,mutations
R7416 T23609 T23608 amod small,percentage
R7417 T23610 T23608 prep of,percentage
R7418 T23611 T23612 amod contaminating,alleles
R7419 T23612 T23610 pobj alleles,of
R742 T3275 T3274 advmod negatively,regulate
R7420 T23613 T23612 compound donor,alleles
R7421 T23614 T23612 acl missed,alleles
R7422 T23615 T23614 prep after,missed
R7423 T23616 T23617 nummod 6,backcrosses
R7424 T23617 T23615 pobj backcrosses,after
R7425 T23618 T23587 punct .,were
R7426 T23620 T23621 advmod Therefore,are
R7427 T23622 T23621 punct ", ",are
R7428 T23623 T23624 mark since,developed
R7429 T23624 T23621 advcl developed,are
R743 T3276 T3277 compound growth,hormone
R7430 T23625 T23626 det the,congenics
R7431 T23626 T23624 nsubjpass congenics,developed
R7432 T23627 T23626 cc and,congenics
R7433 T23628 T23626 conj controls,congenics
R7434 T23629 T23624 auxpass were,developed
R7435 T23630 T23624 prep through,developed
R7436 T23631 T23632 det the,scheme
R7437 T23632 T23630 pobj scheme,through
R7438 T23633 T23632 amod same,scheme
R7439 T23634 T23632 compound selection,scheme
R744 T3158 T3157 amod phenotypic,effects
R7440 T23635 T23624 cc and,developed
R7441 T23636 T23637 advmod possibly,share
R7442 T23637 T23624 conj share,developed
R7443 T23638 T23639 amod common,regions
R7444 T23639 T23637 dobj regions,share
R7445 T23640 T23639 amod contaminating,regions
R7446 T23641 T23621 punct ", ",are
R7447 T23642 T23643 det the,strains
R7448 T23643 T23621 nsubj strains,are
R7449 T23644 T23643 nmod B6C,strains
R745 T3277 T3274 dobj hormone,regulate
R7450 T23645 T23644 cc and,B6C
R7451 T23646 T23644 conj HGC,B6C
R7452 T23647 T23648 det the,control
R7453 T23648 T23621 attr control,are
R7454 T23649 T23648 advmod most,control
R7455 T23650 T23648 amod ideal,control
R7456 T23651 T23652 aux to,compare
R7457 T23652 T23648 advcl compare,control
R7458 T23653 T23654 det each,congenic
R7459 T23654 T23652 dobj congenic,compare
R746 T3278 T3277 punct (,hormone
R7460 T23655 T23621 punct .,are
R7463 T24427 T24428 amod Phenotypic,characterization
R7464 T24430 T24431 compound Trait,data
R7465 T24431 T24432 nsubjpass data,collected
R7466 T24433 T24432 auxpass were,collected
R7467 T24434 T24432 prep on,collected
R7468 T24435 T24436 advmod approximately,40
R7469 T24436 T24437 nummod 40,mice
R747 T3159 T3157 prep of,effects
R7470 T24437 T24434 pobj mice,on
R7471 T24438 T24439 punct (,20
R7472 T24439 T24437 parataxis 20,mice
R7473 T24440 T24439 prep of,20
R7474 T24441 T24442 det each,sex
R7475 T24442 T24440 pobj sex,of
R7476 T24443 T24439 punct ),20
R7477 T24444 T24437 prep from,mice
R7478 T24445 T24446 det each,strain
R7479 T24446 T24444 pobj strain,from
R748 T3279 T3277 appos Gh,hormone
R7480 T24447 T24446 amod congenic,strain
R7481 T24448 T24447 cc and,congenic
R7482 T24449 T24447 conj control,congenic
R7483 T24450 T24432 punct .,collected
R7484 T24452 T24453 aux To,eliminate
R7485 T24453 T24454 advcl eliminate,characterized
R7486 T24455 T24453 dobj parity,eliminate
R7487 T24456 T24453 cc and,eliminate
R7488 T24457 T24453 conj reduce,eliminate
R7489 T24458 T24459 compound litter,size
R749 T3280 T3266 punct ),is
R7490 T24459 T24460 compound size,effects
R7491 T24460 T24457 dobj effects,reduce
R7492 T24461 T24462 advmod only,progeny
R7493 T24462 T24454 nsubjpass progeny,characterized
R7494 T24463 T24462 prep from,progeny
R7495 T24464 T24465 amod uniparous,dams
R7496 T24465 T24463 pobj dams,from
R7497 T24466 T24454 auxpass were,characterized
R7498 T24467 T24454 cc and,characterized
R7499 T24468 T24469 det all,litters
R75 T657 T659 nmod EiJ,alleles
R750 T3281 T3282 punct [,23
R7500 T24469 T24470 nsubjpass litters,standardized
R7501 T24470 T24454 conj standardized,characterized
R7502 T24471 T24470 auxpass were,standardized
R7503 T24472 T24470 prep to,standardized
R7504 T24473 T24474 quantmod 5,7
R7505 T24474 T24476 nummod 7,pups
R7506 T24475 T24474 punct –,7
R7507 T24476 T24472 pobj pups,to
R7508 T24477 T24478 punct /,litter
R7509 T24478 T24476 prep litter,pups
R751 T3282 T3266 parataxis 23,is
R7510 T24479 T24470 punct .,standardized
R7511 T24481 T24482 nsubjpass Mice,weaned
R7512 T24483 T24482 auxpass were,weaned
R7513 T24484 T24482 prep at,weaned
R7514 T24485 T24486 nummod 3,weeks
R7515 T24486 T24484 pobj weeks,at
R7516 T24487 T24486 prep of,weeks
R7517 T24488 T24487 pobj age,of
R7518 T24489 T24482 punct .,weaned
R7519 T24491 T24492 nsubjpass Feed,offered
R752 T3160 T3161 det another,locus
R7520 T24493 T24494 punct (,protein
R7521 T24494 T24491 parataxis protein,Feed
R7522 T24495 T24494 dep Purina,protein
R7523 T24496 T24495 nummod 5008,Purina
R7524 T24497 T24494 punct ;,protein
R7525 T24498 T24499 nummod 23.5,%
R7526 T24499 T24494 compound %,protein
R7527 T24500 T24494 punct ", ",protein
R7528 T24501 T24502 nummod 6.5,%
R7529 T24502 T24503 compound %,fat
R753 T3283 T3282 punct ],23
R7530 T24503 T24494 appos fat,protein
R7531 T24504 T24494 punct ", ",protein
R7532 T24505 T24506 nummod 3.3,Kcal
R7533 T24506 T24494 appos Kcal,protein
R7534 T24507 T24508 punct /,g
R7535 T24508 T24506 prep g,Kcal
R7536 T24509 T24494 punct ),protein
R7537 T24510 T24491 cc and,Feed
R7538 T24511 T24491 conj water,Feed
R7539 T24512 T24492 auxpass were,offered
R754 T3284 T3272 punct ", ",is
R7540 T24513 T24514 advmod ad,libitum
R7541 T24514 T24492 advmod libitum,offered
R7542 T24515 T24492 punct .,offered
R7543 T24517 T24518 nsubjpass Mice,weighed
R7544 T24519 T24518 auxpass were,weighed
R7545 T24520 T24518 prep to,weighed
R7546 T24521 T24522 det the,g
R7547 T24522 T24520 pobj g,to
R7548 T24523 T24522 amod nearest,g
R7549 T24524 T24522 nummod 0.1,g
R755 T3285 T3272 nsubj it,is
R7550 T24525 T24518 prep at,weighed
R7551 T24526 T24525 pobj 2WK,at
R7552 T24527 T24526 punct ", ",2WK
R7553 T24528 T24526 conj 3WK,2WK
R7554 T24529 T24528 punct ", ",3WK
R7555 T24530 T24528 conj 6WK,3WK
R7556 T24531 T24530 punct ", ",6WK
R7557 T24532 T24530 cc and,6WK
R7558 T24533 T24530 conj 9WK,6WK
R7559 T24534 T24526 prep of,2WK
R756 T3161 T3159 pobj locus,of
R7560 T24535 T24534 pobj age,of
R7561 T24536 T24518 punct .,weighed
R7562 T24538 T24539 prep At,anesthetized
R7563 T24540 T24538 pobj 9WK,At
R7564 T24541 T24540 punct (,9WK
R7565 T24542 T24540 punct ±,9WK
R7566 T24543 T24544 nummod 5,days
R7567 T24544 T24540 appos days,9WK
R7568 T24545 T24540 punct ),9WK
R7569 T24546 T24539 nsubjpass mice,anesthetized
R757 T3286 T3272 acomp likely,is
R7570 T24547 T24539 auxpass were,anesthetized
R7571 T24548 T24539 prep under,anesthetized
R7572 T24549 T24548 pobj isoflurane,under
R7573 T24550 T24539 cc and,anesthetized
R7574 T24551 T24552 amod nasal,anal
R7575 T24552 T24554 amod anal,length
R7576 T24553 T24552 punct -,anal
R7577 T24554 T24555 nsubjpass length,measured
R7578 T24555 T24539 conj measured,anesthetized
R7579 T24556 T24554 punct (,length
R758 T3287 T3288 det these,effects
R7580 T24557 T24554 appos NA,length
R7581 T24558 T24554 punct ),length
R7582 T24559 T24554 cc and,length
R7583 T24560 T24561 amod nasal,tail
R7584 T24561 T24554 conj tail,length
R7585 T24562 T24561 punct -,tail
R7586 T24563 T24561 punct (,tail
R7587 T24564 T24561 appos NT,tail
R7588 T24565 T24555 punct ),measured
R7589 T24566 T24555 auxpass were,measured
R759 T3162 T3153 auxpass are,referred
R7590 T24567 T24555 prep to,measured
R7591 T24568 T24569 det the,mm
R7592 T24569 T24567 pobj mm,to
R7593 T24570 T24569 amod nearest,mm
R7594 T24571 T24539 punct .,anesthetized
R7595 T24573 T24574 compound Tail,length
R7596 T24574 T24575 nsubjpass length,calculated
R7597 T24576 T24575 auxpass was,calculated
R7598 T24577 T24575 prep as,calculated
R7599 T24578 T24577 pobj NA,as
R76 T658 T657 punct /,EiJ
R760 T3288 T3290 nsubj effects,are
R7600 T24579 T24578 cc minus,NA
R7601 T24580 T24578 conj NT,NA
R7602 T24581 T24575 punct .,calculated
R7603 T24583 T24584 amod Anesthetized,mice
R7604 T24584 T24585 nsubjpass mice,sacrificed
R7605 T24586 T24585 auxpass were,sacrificed
R7606 T24587 T24585 advmod then,sacrificed
R7607 T24588 T24585 prep by,sacrificed
R7608 T24589 T24588 pobj decapitation,by
R7609 T24590 T24585 cc and,sacrificed
R761 T3289 T3288 compound background,effects
R7610 T24591 T24585 conj exsanguinated,sacrificed
R7611 T24592 T24585 punct .,sacrificed
R7612 T24594 T24595 amod Femoral,pad
R7613 T24595 T24597 nsubjpass pad,removed
R7614 T24596 T24595 compound fat,pad
R7615 T24598 T24595 punct (,pad
R7616 T24599 T24595 appos FFP,pad
R7617 T24600 T24595 punct ),pad
R7618 T24601 T24595 punct ", ",pad
R7619 T24602 T24603 amod gonadal,pad
R762 T3163 T3153 prep to,referred
R7620 T24603 T24595 conj pad,pad
R7621 T24604 T24603 compound fat,pad
R7622 T24605 T24603 punct (,pad
R7623 T24606 T24603 appos GFP,pad
R7624 T24607 T24603 punct ),pad
R7625 T24608 T24603 punct ", ",pad
R7626 T24609 T24610 amod mesenteric,pad
R7627 T24610 T24603 conj pad,pad
R7628 T24611 T24610 compound fat,pad
R7629 T24612 T24610 punct (,pad
R763 T3290 T3286 advcl are,likely
R7630 T24613 T24610 appos MFP,pad
R7631 T24614 T24610 punct ),pad
R7632 T24615 T24610 cc and,pad
R7633 T24616 T24617 amod retroperitoneal,pad
R7634 T24617 T24610 conj pad,pad
R7635 T24618 T24617 compound fat,pad
R7636 T24619 T24617 punct (,pad
R7637 T24620 T24617 appos RFP,pad
R7638 T24621 T24597 punct ),removed
R7639 T24622 T24597 auxpass were,removed
R764 T3291 T3292 det the,result
R7640 T24623 T24597 cc and,removed
R7641 T24624 T24597 conj weighed,removed
R7642 T24625 T24624 prep to,weighed
R7643 T24626 T24627 det the,mg
R7644 T24627 T24625 pobj mg,to
R7645 T24628 T24627 amod nearest,mg
R7646 T24629 T24597 punct .,removed
R7647 T24631 T24632 amod Chemical,analysis
R7648 T24632 T24634 nsubjpass analysis,performed
R7649 T24633 T24632 amod compositional,analysis
R765 T3164 T3153 prep as,referred
R7650 T24635 T24634 auxpass was,performed
R7651 T24636 T24634 prep for,performed
R7652 T24637 T24638 nmod HGC,carcasses
R7653 T24638 T24636 pobj carcasses,for
R7654 T24639 T24637 punct ", ",HGC
R7655 T24640 T24637 conj HG11,HGC
R7656 T24641 T24640 cc and,HG11
R7657 T24642 T24640 conj HG17,HG11
R7658 T24643 T24644 mark as,described
R7659 T24644 T24634 advcl described,performed
R766 T3292 T3290 attr result,are
R7660 T24645 T24644 advmod previously,described
R7661 T24646 T24634 prep with,performed
R7662 T24647 T24648 amod slight,modifications
R7663 T24648 T24646 pobj modifications,with
R7664 T24649 T24650 punct [,24
R7665 T24650 T24634 parataxis 24,performed
R7666 T24651 T24650 punct ],24
R7667 T24652 T24634 punct .,performed
R7668 T24654 T24655 advmod Briefly,returned
R7669 T24656 T24655 punct ", ",returned
R767 T3293 T3292 prep of,result
R7670 T24657 T24655 prep after,returned
R7671 T24658 T24657 pobj weighing,after
R7672 T24659 T24660 det each,pad
R7673 T24660 T24655 nsubjpass pad,returned
R7674 T24661 T24660 compound fat,pad
R7675 T24662 T24655 auxpass was,returned
R7676 T24663 T24655 prep to,returned
R7677 T24664 T24665 det the,carcass
R7678 T24665 T24663 pobj carcass,to
R7679 T24666 T24655 punct .,returned
R768 T3294 T3295 nsubj polymorphism,influencing
R7680 T24668 T24669 det The,tract
R7681 T24669 T24675 nsubjpass tract,removed
R7682 T24670 T24669 amod entire,tract
R7683 T24671 T24669 amod gastrointestinal,tract
R7684 T24672 T24673 punct (,GI
R7685 T24673 T24669 parataxis GI,tract
R7686 T24674 T24673 punct ),GI
R7687 T24676 T24675 auxpass was,removed
R7688 T24677 T24675 advmod subsequently,removed
R7689 T24678 T24675 cc and,removed
R769 T3295 T3293 pcomp influencing,of
R7690 T24679 T24680 nsubjpass carcasses,weighed
R7691 T24680 T24675 conj weighed,removed
R7692 T24681 T24680 auxpass were,weighed
R7693 T24682 T24680 advmod again,weighed
R7694 T24683 T24680 punct .,weighed
R7695 T24685 T24686 nsubj This,represented
R7696 T24687 T24688 det the,weight
R7697 T24688 T24686 dobj weight,represented
R7698 T24689 T24690 amod empty,carcass
R7699 T24690 T24688 compound carcass,weight
R77 T659 T655 dobj alleles,introgressing
R770 T3165 T3166 compound modifier,QTL
R7700 T24691 T24688 punct (,weight
R7701 T24692 T24688 appos ECW,weight
R7702 T24693 T24686 punct ),represented
R7703 T24694 T24686 punct .,represented
R7704 T24696 T24697 nsubjpass Carcasses,labeled
R7705 T24698 T24697 auxpass were,labeled
R7706 T24699 T24697 cc and,labeled
R7707 T24700 T24697 conj secured,labeled
R7708 T24701 T24700 prep in,secured
R7709 T24702 T24703 nummod two,layers
R771 T3296 T3295 dobj interactions,influencing
R7710 T24703 T24701 pobj layers,in
R7711 T24704 T24703 prep of,layers
R7712 T24705 T24704 pobj cheesecloth,of
R7713 T24706 T24707 punct (,Fisher
R7714 T24707 T24705 parataxis Fisher,cheesecloth
R7715 T24708 T24707 punct ),Fisher
R7716 T24709 T24700 cc and,secured
R7717 T24710 T24700 conj frozen,secured
R7718 T24711 T24710 prep at,frozen
R7719 T24712 T24713 punct -,20
R772 T3297 T3296 prep between,interactions
R7720 T24713 T24714 nummod 20,°C
R7721 T24714 T24711 pobj °C,at
R7722 T24715 T24710 prep until,frozen
R7723 T24716 T24715 pobj analysis,until
R7724 T24717 T24697 punct .,labeled
R7725 T24719 T24720 prep At,dried
R7726 T24721 T24722 det this,time
R7727 T24722 T24719 pobj time,At
R7728 T24723 T24720 punct ", ",dried
R7729 T24724 T24720 nsubjpass carcasses,dried
R773 T3298 T3297 pobj members,between
R7730 T24725 T24720 auxpass were,dried
R7731 T24726 T24720 dep freeze,dried
R7732 T24727 T24720 punct -,dried
R7733 T24728 T24720 prep for,dried
R7734 T24729 T24730 nummod seven,days
R7735 T24730 T24728 pobj days,for
R7736 T24731 T24720 cc and,dried
R7737 T24732 T24733 compound water,content
R7738 T24733 T24734 nsubjpass content,determined
R7739 T24734 T24720 conj determined,dried
R774 T3166 T3164 pobj QTL,as
R7740 T24735 T24734 auxpass was,determined
R7741 T24736 T24734 prep by,determined
R7742 T24737 T24736 pcomp subtracting,by
R7743 T24738 T24739 det the,weight
R7744 T24739 T24737 dobj weight,subtracting
R7745 T24740 T24741 npadvmod freeze,dried
R7746 T24741 T24739 amod dried,weight
R7747 T24742 T24741 punct -,dried
R7748 T24743 T24737 prep from,subtracting
R7749 T24744 T24743 pobj ECW,from
R775 T3299 T3298 prep of,members
R7750 T24745 T24720 punct .,dried
R7751 T24747 T24748 nsubjpass FAT,followed
R7752 T24749 T24748 auxpass was,followed
R7753 T24750 T24748 advmod then,followed
R7754 T24751 T24748 aux extracted,followed
R7755 T24752 T24748 prep with,followed
R7756 T24753 T24752 pobj ether,with
R7757 T24754 T24748 prep for,followed
R7758 T24755 T24756 nummod 7,days
R7759 T24756 T24754 pobj days,for
R776 T3300 T3301 det the,pathway
R7760 T24757 T24748 punct ", ",followed
R7761 T24758 T24748 agent by,followed
R7762 T24759 T24758 pobj acetone,by
R7763 T24760 T24748 prep for,followed
R7764 T24761 T24762 det an,days
R7765 T24762 T24760 pobj days,for
R7766 T24763 T24762 amod additional,days
R7767 T24764 T24762 nummod 7,days
R7768 T24765 T24748 prep in,followed
R7769 T24766 T24767 det a,apparatus
R777 T3301 T3299 pobj pathway,of
R7770 T24767 T24765 pobj apparatus,in
R7771 T24768 T24767 compound Soxhlet,apparatus
R7772 T24769 T24748 punct .,followed
R7773 T24771 T24772 compound Carcass,ash
R7774 T24772 T24773 nsubjpass ash,determined
R7775 T24774 T24772 punct (,ash
R7776 T24775 T24772 appos ASH,ash
R7777 T24776 T24773 punct ),determined
R7778 T24777 T24773 auxpass was,determined
R7779 T24778 T24773 advcl measuring,determined
R778 T3167 T3168 punct [,18
R7780 T24779 T24780 det the,remains
R7781 T24780 T24778 dobj remains,measuring
R7782 T24781 T24778 prep after,measuring
R7783 T24782 T24783 det a,incineration
R7784 T24783 T24781 pobj incineration,after
R7785 T24784 T24785 nummod 16,hour
R7786 T24785 T24783 compound hour,incineration
R7787 T24786 T24783 prep at,incineration
R7788 T24787 T24788 nummod 575,°C
R7789 T24788 T24786 pobj °C,at
R779 T3302 T3303 compound Gh,signaling
R7790 T24789 T24773 punct .,determined
R7791 T24791 T24792 compound Carcass,protein
R7792 T24792 T24793 nsubjpass protein,calculated
R7793 T24794 T24792 punct (,protein
R7794 T24795 T24792 appos PROT,protein
R7795 T24796 T24793 punct ),calculated
R7796 T24797 T24793 auxpass was,calculated
R7797 T24798 T24793 prep as,calculated
R7798 T24799 T24800 det the,portion
R7799 T24800 T24798 pobj portion,as
R78 T660 T657 punct (,EiJ
R780 T3303 T3301 compound signaling,pathway
R7800 T24801 T24800 amod remaining,portion
R7801 T24802 T24803 mark after,subtracted
R7802 T24803 T24800 advcl subtracted,portion
R7803 T24804 T24805 compound carcass,fat
R7804 T24805 T24803 nsubjpass fat,subtracted
R7805 T24806 T24805 punct (,fat
R7806 T24807 T24805 appos FAT,fat
R7807 T24808 T24805 punct ),fat
R7808 T24809 T24805 cc and,fat
R7809 T24810 T24805 conj ASH,fat
R781 T3304 T3272 punct .,is
R7810 T24811 T24803 auxpass were,subtracted
R7811 T24812 T24803 prep from,subtracted
R7812 T24813 T24812 pobj ECW,from
R7813 T24814 T24793 punct .,calculated
R7814 T25106 T25107 amod Statistical,analysis
R7815 T25109 T25110 det The,procedures
R7816 T25110 T25114 nsubjpass procedures,used
R7817 T25111 T25110 nmod MEANS,procedures
R7818 T25112 T25111 cc and,MEANS
R7819 T25113 T25111 conj UNIVARIATE,MEANS
R782 T3168 T3153 parataxis 18,referred
R7820 T25115 T25110 prep of,procedures
R7821 T25116 T25115 pobj SAS,of
R7822 T25117 T25114 auxpass were,used
R7823 T25118 T25119 aux to,generate
R7824 T25119 T25114 advcl generate,used
R7825 T25120 T25121 amod descriptive,statistics
R7826 T25121 T25119 dobj statistics,generate
R7827 T25122 T25119 cc and,generate
R7828 T25123 T25119 conj test,generate
R7829 T25124 T25125 compound normality,assumptions
R783 T3306 T3307 advmod Thus,has
R7830 T25125 T25123 dobj assumptions,test
R7831 T25126 T25125 prep for,assumptions
R7832 T25127 T25128 det each,trait
R7833 T25128 T25126 pobj trait,for
R7834 T25129 T25130 punct [,55
R7835 T25130 T25114 parataxis 55,used
R7836 T25131 T25130 punct ],55
R7837 T25132 T25114 punct .,used
R7838 T25134 T25135 det All,data
R7839 T25135 T25136 nsubjpass data,analyzed
R784 T3169 T3168 punct ],18
R7840 T25136 T25139 ccomp analyzed,used
R7841 T25137 T25136 auxpass were,analyzed
R7842 T25138 T25136 advmod then,analyzed
R7843 T25140 T25136 advcl using,analyzed
R7844 T25141 T25142 det the,procedure
R7845 T25142 T25140 dobj procedure,using
R7846 T25143 T25142 compound GLM,procedure
R7847 T25144 T25142 prep of,procedure
R7848 T25145 T25144 pobj SAS,of
R7849 T25146 T25147 punct [,55
R785 T3308 T3307 punct ", ",has
R7850 T25147 T25140 parataxis 55,using
R7851 T25148 T25147 punct ],55
R7852 T25149 T25140 prep with,using
R7853 T25150 T25151 det a,model
R7854 T25151 T25149 pobj model,with
R7855 T25152 T25151 amod linear,model
R7856 T25153 T25154 dep that,included
R7857 T25154 T25151 relcl included,model
R7858 T25155 T25156 det the,effects
R7859 T25156 T25154 dobj effects,included
R786 T3309 T3307 nsubj identification,has
R7860 T25157 T25156 amod fixed,effects
R7861 T25158 T25156 prep of,effects
R7862 T25159 T25158 pobj strain,of
R7863 T25160 T25159 punct ", ",strain
R7864 T25161 T25159 conj sex,strain
R7865 T25162 T25161 cc and,sex
R7866 T25163 T25164 nmod strain,interaction
R7867 T25164 T25161 conj interaction,sex
R7868 T25165 T25163 prep by,strain
R7869 T25166 T25165 pobj sex,by
R787 T3170 T3153 punct .,referred
R7870 T25167 T25139 punct ;,used
R7871 T25168 T25169 poss dam,weight
R7872 T25169 T25139 nsubjpass weight,used
R7873 T25170 T25168 case 's,dam
R7874 T25171 T25169 prep at,weight
R7875 T25172 T25171 pobj breeding,at
R7876 T25173 T25172 prep by,breeding
R7877 T25174 T25173 pobj strain,by
R7878 T25175 T25139 auxpass was,used
R7879 T25176 T25139 prep as,used
R788 T3310 T3309 prep of,identification
R7880 T25177 T25178 det a,covariate
R7881 T25178 T25176 pobj covariate,as
R7882 T25179 T25139 punct .,used
R7883 T25181 T25182 det A,model
R7884 T25182 T25185 nsubjpass model,used
R7885 T25183 T25182 amod second,model
R7886 T25184 T25182 amod linear,model
R7887 T25186 T25185 auxpass was,used
R7888 T25187 T25188 aux to,test
R7889 T25188 T25185 advcl test,used
R789 T3311 T3312 compound hg,modifiers
R7890 T25189 T25188 prep for,test
R7891 T25190 T25191 nmod strain,interactions
R7892 T25191 T25189 pobj interactions,for
R7893 T25192 T25190 prep by,strain
R7894 T25193 T25194 compound hg,genotype
R7895 T25194 T25192 pobj genotype,by
R7896 T25195 T25196 punct (,+
R7897 T25196 T25191 punct +,interactions
R7898 T25197 T25196 punct +,+
R7899 T25198 T25196 punct /,+
R79 T661 T657 appos CAST,EiJ
R790 T3312 T3310 pobj modifiers,of
R7900 T25199 T25196 cc or,+
R7901 T25200 T25201 compound hg,hg
R7902 T25201 T25196 conj hg,+
R7903 T25202 T25201 punct /,hg
R7904 T25203 T25196 punct ),+
R7905 T25204 T25185 punct .,used
R7906 T25206 T25207 det This,model
R7907 T25207 T25208 nsubj model,included
R7908 T25209 T25210 det the,effects
R7909 T25210 T25208 dobj effects,included
R791 T3172 T3173 compound Modifier,QTL
R7910 T25211 T25210 amod fixed,effects
R7911 T25212 T25210 prep of,effects
R7912 T25213 T25214 compound donor,region
R7913 T25214 T25212 pobj region,of
R7914 T25215 T25214 punct ", ",region
R7915 T25216 T25214 conj sex,region
R7916 T25217 T25216 cc and,sex
R7917 T25218 T25219 compound HG,genotype
R7918 T25219 T25216 conj genotype,sex
R7919 T25220 T25210 cc and,effects
R792 T3313 T3314 det the,potential
R7920 T25221 T25222 det all,interactions
R7921 T25222 T25210 conj interactions,effects
R7922 T25223 T25222 amod possible,interactions
R7923 T25224 T25225 nummod two,way
R7924 T25225 T25222 compound way,interactions
R7925 T25226 T25224 cc and,two
R7926 T25227 T25224 conj three,two
R7927 T25228 T25225 punct -,way
R7928 T25229 T25208 punct .,included
R7929 T25231 T25232 csubj Choosing,established
R793 T3314 T3307 dobj potential,has
R7930 T25233 T25234 det a,value
R7931 T25234 T25231 dobj value,Choosing
R7932 T25235 T25234 amod nominal,value
R7933 T25236 T25234 compound P,value
R7934 T25237 T25234 prep of,value
R7935 T25238 T25237 pobj 0.05,of
R7936 T25239 T25231 cc and,Choosing
R7937 T25240 T25231 conj applying,Choosing
R7938 T25241 T25242 det the,correction
R7939 T25242 T25240 dobj correction,applying
R794 T3315 T3316 aux to,uncover
R7940 T25243 T25242 compound Bonferroni,correction
R7941 T25244 T25242 prep for,correction
R7942 T25245 T25246 amod multiple,comparisons
R7943 T25246 T25244 pobj comparisons,for
R7944 T25247 T25248 amod significant,differences
R7945 T25248 T25232 dobj differences,established
R7946 T25249 T25248 prep in,differences
R7947 T25250 T25251 det the,ANOVA
R7948 T25251 T25249 pobj ANOVA,in
R7949 T25252 T25251 nmod 's,ANOVA
R795 T3316 T3314 acl uncover,potential
R7950 T25253 T25232 punct .,established
R7951 T25255 T25256 det The,values
R7952 T25256 T25259 nsubjpass values,indicated
R7953 T25257 T25256 amod critical,values
R7954 T25258 T25256 compound P,values
R7955 T25260 T25256 acl used,values
R7956 T25261 T25259 auxpass are,indicated
R7957 T25262 T25259 prep in,indicated
R7958 T25263 T25264 det each,table
R7959 T25264 T25262 pobj table,in
R796 T3173 T3174 nsubjpass QTL,mapped
R7960 T25265 T25259 punct .,indicated
R7961 T25441 T25440 prep of,Identification
R7962 T25442 T25443 compound candidate,genes
R7963 T25443 T25441 pobj genes,of
R7964 T25445 T25446 nsubjpass Genes,identified
R7965 T25447 T25446 auxpass were,identified
R7966 T25448 T25446 agent by,identified
R7967 T25449 T25450 amod manual,mining
R7968 T25450 T25448 pobj mining,by
R7969 T25451 T25450 compound data,mining
R797 T3317 T3318 amod novel,members
R7970 T25452 T25450 prep of,mining
R7971 T25453 T25454 amod primary,literature
R7972 T25454 T25452 pobj literature,of
R7973 T25455 T25454 punct ", ",literature
R7974 T25456 T25454 conj reviews,literature
R7975 T25457 T25456 cc and,reviews
R7976 T25458 T25459 compound book,chapters
R7977 T25459 T25456 conj chapters,reviews
R7978 T25460 T25446 punct .,identified
R7979 T25462 T25463 aux To,organize
R798 T3318 T3316 dobj members,uncover
R7980 T25463 T25464 advcl organize,created
R7981 T25465 T25463 cc and,organize
R7982 T25466 T25463 conj collate,organize
R7983 T25467 T25468 amod genomic,information
R7984 T25468 T25466 dobj information,collate
R7985 T25469 T25467 cc and,genomic
R7986 T25470 T25467 conj functional,genomic
R7987 T25471 T25468 prep for,information
R7988 T25472 T25473 det each,gene
R7989 T25473 T25471 pobj gene,for
R799 T3319 T3318 prep of,members
R7990 T25474 T25464 nsubj we,created
R7991 T25475 T25476 det a,Annotator
R7992 T25476 T25464 dobj Annotator,created
R7993 T25477 T25478 compound custom,Gh
R7994 T25478 T25479 compound Gh,signaling
R7995 T25479 T25476 compound signaling,Annotator
R7996 T25480 T25481 compound Gene,Map
R7997 T25481 T25476 compound Map,Annotator
R7998 T25482 T25476 cc and,Annotator
R7999 T25483 T25484 nmod Pathway,Profiler
R8 T583 T577 acl using,isolation
R80 T662 T659 punct ),alleles
R800 T3320 T3321 advmod metabolically,important
R8000 T25484 T25485 nmod Profiler,pathway
R8001 T25485 T25476 conj pathway,Annotator
R8002 T25486 T25487 punct (,GenMAPP
R8003 T25487 T25484 parataxis GenMAPP,Profiler
R8004 T25488 T25487 punct ),GenMAPP
R8005 T25489 T25490 punct [,56
R8006 T25490 T25464 parataxis 56,created
R8007 T25491 T25490 punct ],56
R8008 T25492 T25493 punct (,Figure
R8009 T25493 T25464 parataxis Figure,created
R801 T3321 T3322 amod important,pathways
R8010 T25494 T25493 nummod 5,Figure
R8011 T25495 T25493 punct ),Figure
R8012 T25496 T25464 punct .,created
R8013 T25498 T25499 nsubj Visualization,aided
R8014 T25500 T25498 cc and,Visualization
R8015 T25501 T25498 conj color,Visualization
R8016 T25502 T25501 punct -,color
R8017 T25503 T25501 amod coding,color
R8018 T25504 T25498 prep of,Visualization
R8019 T25505 T25504 pobj genes,of
R802 T3322 T3319 pobj pathways,of
R8020 T25506 T25498 acl using,Visualization
R8021 T25507 T25506 dobj GenMAPP,using
R8022 T25508 T25509 det the,selection
R8023 T25509 T25499 dobj selection,aided
R8024 T25510 T25509 prep of,selection
R8025 T25511 T25512 compound candidate,genes
R8026 T25512 T25510 pobj genes,of
R8027 T25513 T25512 acl mapping,genes
R8028 T25514 T25513 prep within,mapping
R8029 T25515 T25516 compound QTL,regions
R803 T3175 T3174 aux have,mapped
R8030 T25516 T25514 pobj regions,within
R8031 T25517 T25516 prep on,regions
R8032 T25518 T25519 nmod MMU,2
R8033 T25519 T25517 pobj 2,on
R8034 T25520 T25519 punct ", ",2
R8035 T25521 T25519 conj 9,2
R8036 T25522 T25521 punct ", ",9
R8037 T25523 T25521 conj 11,9
R8038 T25524 T25523 cc and,11
R8039 T25525 T25523 conj 17,11
R804 T3323 T3318 cc or,members
R8040 T25526 T25499 punct .,aided
R8043 T26350 T26351 compound Candidate,gene
R8044 T26351 T26352 compound gene,sequencing
R8045 T26354 T26355 compound PCR,amplicons
R8046 T26355 T26356 nsubjpass amplicons,amplified
R8047 T26357 T26355 acl covering,amplicons
R8048 T26358 T26359 det the,sequence
R8049 T26359 T26357 dobj sequence,covering
R805 T3324 T3325 advmod previously,unknown
R8050 T26360 T26359 compound coding,sequence
R8051 T26361 T26355 cc and,amplicons
R8052 T26362 T26363 amod partial,regions
R8053 T26363 T26355 conj regions,amplicons
R8054 T26364 T26363 nummod 5,regions
R8055 T26365 T26364 punct ',5
R8056 T26366 T26364 cc and,5
R8057 T26367 T26364 conj 3,5
R8058 T26368 T26367 punct ',3
R8059 T26369 T26363 amod untranslated,regions
R806 T3325 T3326 amod unknown,convergences
R8060 T26370 T26363 prep for,regions
R8061 T26371 T26372 det each,gene
R8062 T26372 T26370 pobj gene,for
R8063 T26373 T26372 amod selected,gene
R8064 T26374 T26372 compound candidate,gene
R8065 T26375 T26356 auxpass were,amplified
R8066 T26376 T26356 punct ", ",amplified
R8067 T26377 T26356 conj purified,amplified
R8068 T26378 T26377 cc and,purified
R8069 T26379 T26377 conj sequenced,purified
R807 T3176 T3174 auxpass been,mapped
R8070 T26380 T26379 prep from,sequenced
R8071 T26381 T26382 det the,strain
R8072 T26382 T26380 pobj strain,from
R8073 T26383 T26382 compound CAST,strain
R8074 T26384 T26379 advcl using,sequenced
R8075 T26385 T26384 dobj protocols,using
R8076 T26386 T26385 acl outlined,protocols
R8077 T26387 T26386 prep in,outlined
R8078 T26388 T26389 punct [,57
R8079 T26389 T26387 pobj 57,in
R808 T3177 T3174 prep for,mapped
R8080 T26390 T26389 punct ],57
R8081 T26391 T26385 prep with,protocols
R8082 T26392 T26393 amod slight,modifications
R8083 T26393 T26391 pobj modifications,with
R8084 T26394 T26356 punct .,amplified
R8085 T26396 T26397 amod Total,RNA
R8086 T26397 T26398 nsubjpass RNA,isolated
R8087 T26399 T26397 prep from,RNA
R8088 T26400 T26399 pobj brain,from
R8089 T26401 T26400 punct ", ",brain
R809 T3326 T3318 conj convergences,members
R8090 T26402 T26400 conj liver,brain
R8091 T26403 T26402 punct ", ",liver
R8092 T26404 T26402 conj spleen,liver
R8093 T26405 T26404 punct ", ",spleen
R8094 T26406 T26404 conj lung,spleen
R8095 T26407 T26406 cc and,lung
R8096 T26408 T26406 conj testis,lung
R8097 T26409 T26398 auxpass was,isolated
R8098 T26410 T26398 prep from,isolated
R8099 T26411 T26412 det an,mouse
R81 T663 T659 compound QTL,alleles
R810 T3178 T3179 amod numerous,traits
R8100 T26412 T26410 pobj mouse,from
R8101 T26413 T26412 amod adult,mouse
R8102 T26414 T26412 nmod CAST,mouse
R8103 T26415 T26412 amod male,mouse
R8104 T26416 T26398 advcl using,isolated
R8105 T26417 T26416 dobj Trizol,using
R8106 T26418 T26419 punct (,Ambion
R8107 T26419 T26417 parataxis Ambion,Trizol
R8108 T26420 T26419 punct ),Ambion
R8109 T26421 T26398 punct .,isolated
R811 T3327 T3326 prep between,convergences
R8110 T26423 T26424 nsubjpass cDNA,produced
R8111 T26425 T26424 auxpass was,produced
R8112 T26426 T26424 prep from,produced
R8113 T26427 T26428 amod total,RNA
R8114 T26428 T26426 pobj RNA,from
R8115 T26429 T26424 advcl using,produced
R8116 T26430 T26431 amod standard,procedures
R8117 T26431 T26429 dobj procedures,using
R8118 T26432 T26424 punct .,produced
R8119 T26434 T26435 compound PCR,sets
R812 T3328 T3327 pobj pathways,between
R8120 T26435 T26437 nsubjpass sets,designed
R8121 T26436 T26435 compound primer,sets
R8122 T26438 T26435 prep for,sets
R8123 T26439 T26440 det each,gene
R8124 T26440 T26438 pobj gene,for
R8125 T26441 T26437 auxpass were,designed
R8126 T26442 T26437 advcl using,designed
R8127 T26443 T26442 dobj Primer3,using
R8128 T26444 T26445 punct [,58
R8129 T26445 T26437 parataxis 58,designed
R813 T3329 T3307 punct .,has
R8130 T26446 T26445 punct ],58
R8131 T26447 T26448 punct (,File
R8132 T26448 T26437 parataxis File,designed
R8133 T26449 T26448 amod Additional,File
R8134 T26450 T26448 nummod 5,File
R8135 T26451 T26448 punct ),File
R8136 T26452 T26437 punct .,designed
R8137 T26454 T26455 det The,amplification
R8138 T26455 T26457 nsubjpass amplification,performed
R8139 T26456 T26455 amod initial,amplification
R814 T3179 T3177 pobj traits,for
R8140 T26458 T26457 auxpass was,performed
R8141 T26459 T26457 prep in,performed
R8142 T26460 T26461 nummod 10,μl
R8143 T26461 T26462 compound μl,reactions
R8144 T26462 T26459 pobj reactions,in
R8145 T26463 T26462 compound PCR,reactions
R8146 T26464 T26457 advcl using,performed
R8147 T26465 T26466 det the,system
R8148 T26466 T26464 dobj system,using
R8149 T26467 T26466 compound Invitrogen,system
R815 T3331 T3332 prep As,identified
R8150 T26468 T26466 compound Platinum,system
R8151 T26469 T26470 compound TaqPCRx,amplification
R8152 T26470 T26466 compound amplification,system
R8153 T26471 T26472 punct (,Invitrogen
R8154 T26472 T26466 parataxis Invitrogen,system
R8155 T26473 T26472 punct ),Invitrogen
R8156 T26474 T26457 punct .,performed
R8157 T26476 T26477 det The,reactions
R8158 T26477 T26478 nsubj reactions,contained
R8159 T26479 T26480 compound 1X,buffer
R816 T3180 T3174 cc and,mapped
R8160 T26480 T26478 dobj buffer,contained
R8161 T26481 T26480 compound PCR,buffer
R8162 T26482 T26480 punct ", ",buffer
R8163 T26483 T26484 compound 1X,solution
R8164 T26484 T26480 conj solution,buffer
R8165 T26485 T26484 compound Enhancer,solution
R8166 T26486 T26484 punct ", ",solution
R8167 T26487 T26488 nummod 1.5,mM
R8168 T26488 T26489 compound mM,MgSO4
R8169 T26489 T26484 conj MgSO4,solution
R817 T3333 T3334 det an,step
R8170 T26490 T26489 punct ", ",MgSO4
R8171 T26491 T26492 nummod 0.17,mM
R8172 T26492 T26493 compound mM,dNTPs
R8173 T26493 T26489 conj dNTPs,MgSO4
R8174 T26494 T26493 punct ", ",dNTPs
R8175 T26495 T26496 nummod 1,μM
R8176 T26496 T26497 nmod μM,primer
R8177 T26497 T26493 conj primer,dNTPs
R8178 T26498 T26497 det each,primer
R8179 T26499 T26497 punct ", ",primer
R818 T3334 T3331 pobj step,As
R8180 T26500 T26501 nummod 0.1,unit
R8181 T26501 T26497 conj unit,primer
R8182 T26502 T26501 prep of,unit
R8183 T26503 T26504 compound Platinum,Taq
R8184 T26504 T26502 pobj Taq,of
R8185 T26505 T26506 punct (,Invitrogen
R8186 T26506 T26504 parataxis Invitrogen,Taq
R8187 T26507 T26506 punct ),Invitrogen
R8188 T26508 T26501 cc and,unit
R8189 T26509 T26510 advmod approximately,25
R819 T3181 T3182 prep in,is
R8190 T26510 T26511 nummod 25,ng
R8191 T26511 T26501 conj ng,unit
R8192 T26512 T26511 prep of,ng
R8193 T26513 T26512 pobj cDNA,of
R8194 T26514 T26478 punct .,contained
R8195 T26516 T26517 nsubjpass Reactions,incubated
R8196 T26518 T26517 auxpass were,incubated
R8197 T26519 T26517 prep for,incubated
R8198 T26520 T26521 nummod 5,min
R8199 T26521 T26519 pobj min,for
R82 T664 T655 prep onto,introgressing
R820 T3335 T3334 amod initial,step
R8200 T26522 T26517 prep at,incubated
R8201 T26523 T26524 nummod 95,°C
R8202 T26524 T26522 pobj °C,at
R8203 T26525 T26517 punct ", ",incubated
R8204 T26526 T26527 advmod then,cycled
R8205 T26527 T26517 dep cycled,incubated
R8206 T26528 T26527 prep for,cycled
R8207 T26529 T26530 nummod 45,s
R8208 T26530 T26528 pobj s,for
R8209 T26531 T26530 prep at,s
R821 T3336 T3332 punct ", ",identified
R8210 T26532 T26533 nummod 95,°C
R8211 T26533 T26531 pobj °C,at
R8212 T26534 T26530 punct ", ",s
R8213 T26535 T26536 nummod 45,s
R8214 T26536 T26530 appos s,s
R8215 T26537 T26536 prep at,s
R8216 T26538 T26539 nummod 55,°C
R8217 T26539 T26537 pobj °C,at
R8218 T26540 T26530 punct ", ",s
R8219 T26541 T26542 nummod 1,min
R822 T3337 T3338 nmod growth,QTL
R8220 T26542 T26530 appos min,s
R8221 T26543 T26542 prep at,min
R8222 T26544 T26545 nummod 72,°C
R8223 T26545 T26543 pobj °C,at
R8224 T26546 T26542 prep for,min
R8225 T26547 T26548 nummod 35,cycles
R8226 T26548 T26546 pobj cycles,for
R8227 T26549 T26527 prep with,cycled
R8228 T26550 T26551 det a,extension
R8229 T26551 T26549 pobj extension,with
R823 T3182 T3174 conj is,mapped
R8230 T26552 T26551 amod final,extension
R8231 T26553 T26554 nummod 72,°C
R8232 T26554 T26551 compound °C,extension
R8233 T26555 T26551 prep for,extension
R8234 T26556 T26557 nummod 10,min
R8235 T26557 T26555 pobj min,for
R8236 T26558 T26551 prep on,extension
R8237 T26559 T26560 det a,PTC
R8238 T26560 T26558 pobj PTC,on
R8239 T26561 T26562 compound MJ,Research
R824 T3338 T3332 nsubjpass QTL,identified
R8240 T26562 T26560 compound Research,PTC
R8241 T26563 T26560 punct -,PTC
R8242 T26564 T26560 nummod 200,PTC
R8243 T26565 T26517 punct .,incubated
R8244 T26567 T26568 det The,products
R8245 T26568 T26569 nsubjpass products,visualized
R8246 T26570 T26569 auxpass were,visualized
R8247 T26571 T26569 prep on,visualized
R8248 T26572 T26573 nummod 1.5,%
R8249 T26573 T26574 compound %,agarose
R825 T3339 T3337 cc and,growth
R8250 T26574 T26575 compound agarose,gels
R8251 T26575 T26571 pobj gels,on
R8252 T26576 T26575 acl containing,gels
R8253 T26577 T26578 nummod 0.06,μg
R8254 T26578 T26579 nmod μg,EtBr
R8255 T26579 T26576 dobj EtBr,containing
R8256 T26580 T26581 punct /,ml
R8257 T26581 T26578 prep ml,μg
R8258 T26582 T26569 punct .,visualized
R8259 T26584 T26585 nsubjpass Bands,excised
R826 T3340 T3341 compound carcass,composition
R8260 T26586 T26584 prep of,Bands
R8261 T26587 T26588 det the,size
R8262 T26588 T26586 pobj size,of
R8263 T26589 T26588 amod correct,size
R8264 T26590 T26585 auxpass were,excised
R8265 T26591 T26585 cc and,excised
R8266 T26592 T26585 conj incubated,excised
R8267 T26593 T26592 prep in,incubated
R8268 T26594 T26595 nummod 100,μl
R8269 T26595 T26593 pobj μl,in
R827 T3183 T3184 det these,studies
R8270 T26596 T26595 prep of,μl
R8271 T26597 T26598 amod sterile,H2O
R8272 T26598 T26596 pobj H2O,of
R8273 T26599 T26598 prep at,H2O
R8274 T26600 T26601 nummod 80,°C
R8275 T26601 T26599 pobj °C,at
R8276 T26602 T26592 prep for,incubated
R8277 T26603 T26604 nummod 10,min
R8278 T26604 T26602 pobj min,for
R8279 T26605 T26606 aux to,elute
R828 T3341 T3337 conj composition,growth
R8280 T26606 T26592 advcl elute,incubated
R8281 T26607 T26606 dobj DNA,elute
R8282 T26608 T26585 punct .,excised
R8283 T26610 T26611 compound Reamplification,reactions
R8284 T26611 T26612 nsubj reactions,consisted
R8285 T26613 T26612 prep of,consisted
R8286 T26614 T26615 compound 1X,buffer
R8287 T26615 T26613 pobj buffer,of
R8288 T26616 T26615 compound PCR,buffer
R8289 T26617 T26615 punct ", ",buffer
R829 T3342 T3332 auxpass were,identified
R8290 T26618 T26619 nummod 1.5,mM
R8291 T26619 T26620 compound mM,MgCl2
R8292 T26620 T26615 conj MgCl2,buffer
R8293 T26621 T26620 punct ", ",MgCl2
R8294 T26622 T26623 nummod 0.17,mM
R8295 T26623 T26624 compound mM,dNTPs
R8296 T26624 T26620 conj dNTPs,MgCl2
R8297 T26625 T26624 punct ", ",dNTPs
R8298 T26626 T26627 nummod 1,μM
R8299 T26627 T26628 nmod μM,primer
R83 T665 T666 preconj either,hg
R830 T3343 T3332 prep in,identified
R8300 T26628 T26624 conj primer,dNTPs
R8301 T26629 T26628 det each,primer
R8302 T26630 T26628 punct ", ",primer
R8303 T26631 T26632 nummod 0.1,unit
R8304 T26632 T26628 conj unit,primer
R8305 T26633 T26632 prep of,unit
R8306 T26634 T26633 pobj Taq,of
R8307 T26635 T26636 punct (,Promega
R8308 T26636 T26634 parataxis Promega,Taq
R8309 T26637 T26636 punct ),Promega
R831 T3184 T3181 pobj studies,in
R8310 T26638 T26632 cc and,unit
R8311 T26639 T26640 nummod 10,μl
R8312 T26640 T26632 conj μl,unit
R8313 T26641 T26640 prep of,μl
R8314 T26642 T26641 pobj eluate,of
R8315 T26643 T26615 prep in,buffer
R8316 T26644 T26645 det a,volume
R8317 T26645 T26643 pobj volume,in
R8318 T26646 T26645 amod total,volume
R8319 T26647 T26645 prep of,volume
R832 T3344 T3345 det a,cross
R8320 T26648 T26649 nummod 50,μl
R8321 T26649 T26647 pobj μl,of
R8322 T26650 T26612 punct .,consisted
R8323 T26652 T26653 det The,parameters
R8324 T26653 T26656 nsubjpass parameters,used
R8325 T26654 T26653 amod same,parameters
R8326 T26655 T26653 compound cycling,parameters
R8327 T26657 T26656 auxpass were,used
R8328 T26658 T26656 prep for,used
R8329 T26659 T26660 compound reamplification,reactions
R833 T3345 T3343 pobj cross,in
R8330 T26660 T26658 pobj reactions,for
R8331 T26661 T26656 punct .,used
R8332 T26663 T26664 nsubjpass Products,visualized
R8333 T26665 T26664 auxpass were,visualized
R8334 T26666 T26664 prep on,visualized
R8335 T26667 T26668 nummod 1,%
R8336 T26668 T26669 compound %,gels
R8337 T26669 T26666 pobj gels,on
R8338 T26670 T26669 compound 0.5X,gels
R8339 T26671 T26669 compound TBE,gels
R834 T3346 T3345 prep between,cross
R8340 T26672 T26669 compound agarose,gels
R8341 T26673 T26669 acl containing,gels
R8342 T26674 T26675 nummod 0.06,μg
R8343 T26675 T26676 nmod μg,EtBr
R8344 T26676 T26673 dobj EtBr,containing
R8345 T26677 T26678 punct /,ml
R8346 T26678 T26675 prep ml,μg
R8347 T26679 T26664 punct ", ",visualized
R8348 T26680 T26664 conj excised,visualized
R8349 T26681 T26680 cc and,excised
R835 T3185 T3186 det the,locus
R8350 T26682 T26680 conj purfied,excised
R8351 T26683 T26682 advcl using,purfied
R8352 T26684 T26685 compound PCR,purification
R8353 T26685 T26686 compound purification,columns
R8354 T26686 T26683 dobj columns,using
R8355 T26687 T26688 punct (,Promega
R8356 T26688 T26686 parataxis Promega,columns
R8357 T26689 T26688 punct ),Promega
R8358 T26690 T26664 punct .,visualized
R8359 T26692 T26693 aux To,quantity
R836 T3347 T3348 compound CAST,EiJ
R8360 T26693 T26694 advcl quantity,run
R8361 T26695 T26696 det each,fragment
R8362 T26696 T26693 dobj fragment,quantity
R8363 T26697 T26698 nummod 1,μl
R8364 T26698 T26694 nsubjpass μl,run
R8365 T26699 T26698 prep of,μl
R8366 T26700 T26701 det each,product
R8367 T26701 T26699 pobj product,of
R8368 T26702 T26701 amod purified,product
R8369 T26703 T26694 auxpass was,run
R837 T3348 T3346 pobj EiJ,between
R8370 T26704 T26694 prep on,run
R8371 T26705 T26706 det a,gel
R8372 T26706 T26704 pobj gel,on
R8373 T26707 T26708 nummod 1.0,%
R8374 T26708 T26706 compound %,gel
R8375 T26709 T26706 compound agarose,gel
R8376 T26710 T26706 acl containing,gel
R8377 T26711 T26712 nummod 0.06,μg
R8378 T26712 T26713 nmod μg,EtBr
R8379 T26713 T26710 dobj EtBr,containing
R838 T3349 T3348 punct /,EiJ
R8380 T26714 T26715 punct /,ml
R8381 T26715 T26712 prep ml,μg
R8382 T26716 T26706 punct ", ",gel
R8383 T26717 T26706 prep along,gel
R8384 T26718 T26717 prep with,along
R8385 T26719 T26720 det a,ladder
R8386 T26720 T26718 pobj ladder,with
R8387 T26721 T26720 compound DNA,ladder
R8388 T26722 T26720 compound mass,ladder
R8389 T26723 T26724 punct (,Invitrogen
R839 T3186 T3182 nsubj locus,is
R8390 T26724 T26720 parataxis Invitrogen,ladder
R8391 T26725 T26724 punct ),Invitrogen
R8392 T26726 T26694 punct .,run
R8393 T26728 T26729 prep In,added
R8394 T26730 T26731 det a,plate
R8395 T26731 T26728 pobj plate,In
R8396 T26732 T26733 nummod 96,well
R8397 T26733 T26731 compound well,plate
R8398 T26734 T26729 punct ", ",added
R8399 T26735 T26736 nummod 15,ng
R84 T666 T674 nmod hg,backgrounds
R840 T3350 T3348 punct (,EiJ
R8400 T26736 T26729 nsubjpass ng,added
R8401 T26737 T26736 prep of,ng
R8402 T26738 T26739 det each,product
R8403 T26739 T26737 pobj product,of
R8404 T26740 T26739 compound PCR,product
R8405 T26741 T26729 auxpass was,added
R8406 T26742 T26729 prep to,added
R8407 T26743 T26744 nummod 5,pM
R8408 T26744 T26742 pobj pM,to
R8409 T26745 T26744 prep of,pM
R841 T3351 T3348 appos CAST,EiJ
R8410 T26746 T26745 pobj primer,of
R8411 T26747 T26729 prep for,added
R8412 T26748 T26747 pobj sequencing,for
R8413 T26749 T26729 punct .,added
R8414 T26751 T26752 det The,College
R8415 T26752 T26753 nmod College,Facility
R8416 T26753 T26763 nsubj Facility,performed
R8417 T26754 T26752 prep of,College
R8418 T26755 T26756 nmod Agriculture,Sciences
R8419 T26756 T26754 pobj Sciences,of
R842 T3352 T3348 punct ),EiJ
R8420 T26757 T26755 cc and,Agriculture
R8421 T26758 T26755 conj Environmental,Agriculture
R8422 T26759 T26752 punct (,College
R8423 T26760 T26752 appos CAES,College
R8424 T26761 T26753 punct ),Facility
R8425 T26762 T26753 compound Genomics,Facility
R8426 T26764 T26753 prep at,Facility
R8427 T26765 T26766 det the,University
R8428 T26766 T26764 pobj University,at
R8429 T26767 T26766 prep of,University
R843 T3187 T3186 amod modified,locus
R8430 T26768 T26767 pobj California,of
R8431 T26769 T26766 punct ", ",University
R8432 T26770 T26766 npadvmod Davis,University
R8433 T26771 T26763 punct ", ",performed
R8434 T26772 T26773 amod bidirectional,sequencing
R8435 T26773 T26763 dobj sequencing,performed
R8436 T26774 T26773 prep of,sequencing
R8437 T26775 T26776 det each,amplicon
R8438 T26776 T26774 pobj amplicon,of
R8439 T26777 T26763 punct .,performed
R844 T3353 T3348 cc and,EiJ
R8440 T26935 T26936 compound Sequence,analysis
R8441 T26938 T26939 compound B6,sequences
R8442 T26939 T26941 nsubjpass sequences,downloaded
R8443 T26940 T26939 compound mRNA,sequences
R8444 T26942 T26939 prep for,sequences
R8445 T26943 T26944 det each,gene
R8446 T26944 T26942 pobj gene,for
R8447 T26945 T26941 auxpass were,downloaded
R8448 T26946 T26941 prep from,downloaded
R8449 T26947 T26948 det the,assembly
R845 T3354 T3348 conj HG,EiJ
R8450 T26948 T26946 pobj assembly,from
R8451 T26949 T26948 nmod May,assembly
R8452 T26950 T26949 nummod 2004,May
R8453 T26951 T26952 punct (,mm5
R8454 T26952 T26948 parataxis mm5,assembly
R8455 T26953 T26952 punct ),mm5
R8456 T26954 T26948 nmod UCSC,assembly
R8457 T26955 T26956 punct (,Build
R8458 T26956 T26948 parataxis Build,assembly
R8459 T26957 T26956 compound NCBI,Build
R846 T3355 T3356 punct [,24
R8460 T26958 T26956 nummod 33,Build
R8461 T26959 T26956 punct ),Build
R8462 T26960 T26948 compound genome,assembly
R8463 T26961 T26962 punct [,28
R8464 T26962 T26941 parataxis 28,downloaded
R8465 T26963 T26962 punct ],28
R8466 T26964 T26941 punct .,downloaded
R8467 T26966 T26967 det These,sequences
R8468 T26967 T26968 nsubjpass sequences,imported
R8469 T26969 T26968 auxpass were,imported
R847 T3188 T3182 advmod typically,is
R8470 T26970 T26968 prep along,imported
R8471 T26971 T26970 prep with,along
R8472 T26972 T26973 det all,traces
R8473 T26973 T26971 pobj traces,with
R8474 T26974 T26975 compound CAST,sequence
R8475 T26975 T26973 compound sequence,traces
R8476 T26976 T26968 prep into,imported
R8477 T26977 T26978 det the,program
R8478 T26978 T26976 pobj program,into
R8479 T26979 T26978 compound SeqMan,program
R848 T3356 T3332 parataxis 24,identified
R8480 T26980 T26981 compound sequence,assembly
R8481 T26981 T26978 compound assembly,program
R8482 T26982 T26983 punct (,DNASTAR
R8483 T26983 T26978 parataxis DNASTAR,program
R8484 T26984 T26983 punct ),DNASTAR
R8485 T26985 T26968 cc and,imported
R8486 T26986 T26987 advmod manually,curated
R8487 T26987 T26968 conj curated,imported
R8488 T26988 T26987 prep for,curated
R8489 T26989 T26988 pobj quality,for
R849 T3357 T3356 punct ],24
R8490 T26990 T26968 punct .,imported
R8491 T26992 T26993 amod Poor,quality
R8492 T26993 T26994 compound quality,reads
R8493 T26994 T26995 nsubjpass reads,resequenced
R8494 T26996 T26995 auxpass were,resequenced
R8495 T26997 T26995 punct .,resequenced
R8496 T26999 T27000 amod Individual,contigs
R8497 T27000 T27001 nsubjpass contigs,created
R8498 T27002 T27001 auxpass were,created
R8499 T27003 T27001 prep for,created
R85 T667 T666 nmod mutant,hg
R850 T3358 T3332 punct .,identified
R8500 T27004 T27005 det each,gene
R8501 T27005 T27003 pobj gene,for
R8502 T27006 T27001 cc and,created
R8503 T27007 T27008 nsubjpass polymorphisms,detected
R8504 T27008 T27001 conj detected,created
R8505 T27009 T27008 auxpass were,detected
R8506 T27010 T27008 cc and,detected
R8507 T27011 T27008 conj curated,detected
R8508 T27012 T27011 prep by,curated
R8509 T27013 T27014 amod manual,inspection
R851 T3189 T3190 det a,gene
R8510 T27014 T27012 pobj inspection,by
R8511 T27015 T27008 punct .,detected
R852 T3360 T3361 prep In,assayed
R853 T3362 T3363 det the,F2
R854 T3363 T3360 pobj F2,In
R855 T3364 T3361 punct ", ",assayed
R856 T3190 T3182 attr gene,is
R857 T3365 T3361 nsubjpass mice,assayed
R858 T3366 T3365 amod homozygous,mice
R859 T3191 T3190 amod known,gene
R86 T668 T666 nmod C57Bl,hg
R860 T3367 T3366 prep for,homozygous
R861 T3192 T3190 acl containing,gene
R862 T3368 T3369 det the,deletion
R863 T3369 T3367 pobj deletion,for
R864 T3193 T3194 det a,mutation
R865 T3370 T3369 compound hg,deletion
R866 T3371 T3372 punct (,hg
R867 T3372 T3369 parataxis hg,deletion
R868 T3194 T3192 dobj mutation,containing
R869 T3373 T3372 compound hg,hg
R87 T669 T666 punct /,hg
R870 T3374 T3372 punct /,hg
R871 T3375 T3372 punct ),hg
R872 T3195 T3196 advmod spontaneously,arisen
R873 T3376 T3366 cc and,homozygous
R874 T3196 T3194 amod arisen,mutation
R875 T3377 T3378 amod wild,type
R876 T3378 T3366 conj type,homozygous
R877 T3379 T3378 punct (,type
R878 T3380 T3381 punct +,+
R879 T3197 T3196 cc or,arisen
R88 T670 T666 nmod 6J,hg
R880 T3381 T3378 appos +,type
R881 T3382 T3381 punct /,+
R882 T3383 T3361 punct ),assayed
R883 T3198 T3196 conj engineered,arisen
R884 T3384 T3361 auxpass were,assayed
R885 T3385 T3361 cc and,assayed
R886 T3199 T3194 prep with,mutation
R887 T3386 T3387 compound hg,modifier
R888 T3387 T3388 compound modifier,QTL
R889 T3388 T3389 nsubjpass QTL,defined
R89 T671 T666 punct -,hg
R890 T3389 T3361 conj defined,assayed
R891 T3200 T3201 amod major,effects
R892 T3390 T3389 auxpass were,defined
R893 T3391 T3389 prep as,defined
R894 T3392 T3391 pobj those,as
R895 T3201 T3199 pobj effects,with
R896 T3393 T3392 preconj either,those
R897 T3394 T3392 amod absent,those
R898 T3202 T3201 amod phenotypic,effects
R899 T3395 T3394 prep in,absent
R9 T584 T585 compound mouse,speed
R90 T672 T666 nmod hg,hg
R900 T3396 T3397 punct +,+
R901 T3397 T3399 punct +,mice
R902 T3398 T3397 punct /,+
R903 T3203 T3194 punct ", ",mutation
R904 T3399 T3395 pobj mice,in
R905 T3400 T3394 cc and,absent
R906 T3401 T3394 conj segregating,absent
R907 T3402 T3401 prep in,segregating
R908 T3403 T3404 compound hg,hg
R909 T3404 T3402 pobj hg,in
R91 T673 T666 punct /,hg
R910 T3204 T3205 amod such,as
R911 T3405 T3404 punct /,hg
R912 T3406 T3392 cc or,those
R913 T3407 T3392 conj loci,those
R914 T3408 T3407 prep with,loci
R915 T3205 T3194 prep as,mutation
R916 T3409 T3410 amod altered,action
R917 T3410 T3408 pobj action,with
R918 T3411 T3410 compound gene,action
R919 T3206 T3205 pobj hg,as
R92 T674 T664 pobj backgrounds,onto
R920 T3412 T3410 amod dependent,action
R921 T3413 T3412 prep on,dependent
R922 T3414 T3413 pobj background,on
R923 T3207 T3208 punct [,11
R924 T3415 T3389 punct .,defined
R925 T3208 T3182 parataxis 11,is
R926 T3417 T3418 nummod Four,hg
R927 T3418 T3419 compound hg,QTL
R928 T3419 T3421 nsubjpass QTL,identified
R929 T3420 T3419 compound modifier,QTL
R93 T675 T676 punct (,HG
R930 T3209 T3208 punct ",",11
R931 T3422 T3419 punct (,QTL
R932 T3423 T3419 appos Wg2,QTL
R933 T3210 T3208 appos 19,11
R934 T3424 T3423 prep on,Wg2
R935 T3425 T3424 pobj MMU2,on
R936 T3426 T3423 punct ", ",Wg2
R937 T3211 T3212 punct -,21
R938 T3427 T3423 conj Carfhg2,Wg2
R939 T3428 T3427 prep on,Carfhg2
R94 T676 T666 parataxis HG,hg
R940 T3429 T3428 pobj MMU9,on
R941 T3212 T3210 prep 21,19
R942 T3430 T3427 punct ", ",Carfhg2
R943 T3213 T3208 punct ],11
R944 T3214 T3182 punct .,is
R945 T3431 T3427 conj Carp2,Carfhg2
R946 T3216 T3217 nsubj Epistasis,forms
R947 T3432 T3431 prep on,Carp2
R948 T3433 T3432 pobj MMU11,on
R949 T3434 T3431 cc and,Carp2
R95 T677 T676 punct ),HG
R950 T3435 T3431 conj Feml3,Carp2
R951 T3218 T3219 det the,basis
R952 T3436 T3435 prep on,Feml3
R953 T3437 T3436 pobj MMU17,on
R954 T3438 T3419 punct ),QTL
R955 T3219 T3217 dobj basis,forms
R956 T3439 T3421 auxpass were,identified
R957 T3440 T3421 punct ", ",identified
R958 T3441 T3421 prep along,identified
R959 T3442 T3441 prep with,along
R96 T678 T666 cc or,hg
R960 T3443 T3444 nummod 12,QTL
R961 T3444 T3442 pobj QTL,with
R962 T3445 T3444 amod additional,QTL
R963 T3537 T3536 prep of,outside
R964 T3446 T3444 punct (,QTL
R965 T3447 T3444 appos Q1Ucd1,QTL
R966 T3448 T3447 prep on,Q1Ucd1
R967 T3538 T3537 pobj MMU2,of
R968 T3449 T3448 pobj MMU1,on
R969 T3450 T3444 punct (,QTL
R97 T679 T680 amod wild,type
R970 T3539 T3526 punct ", ",created
R971 T3451 T3452 dep which,reached
R972 T3452 T3444 relcl reached,QTL
R973 T3453 T3452 advmod only,reached
R974 T3540 T3541 mark while,developed
R975 T3454 T3455 det a,level
R976 T3455 T3452 dobj level,reached
R977 T3456 T3455 amod suggestive,level
R978 T3541 T3526 advcl developed,created
R979 T3457 T3455 prep of,level
R98 T680 T666 conj type,hg
R980 T3458 T3459 amod statistical,significance
R981 T3459 T3457 pobj significance,of
R982 T3460 T3444 punct ),QTL
R983 T3542 T3543 det a,panel
R984 T3461 T3444 punct ", ",QTL
R985 T3462 T3444 appos Wg1,QTL
R986 T3543 T3541 nsubjpass panel,developed
R987 T3463 T3462 punct ", ",Wg1
R988 T3464 T3462 conj Carp1,Wg1
R989 T3465 T3464 punct ", ",Carp1
R99 T681 T682 compound C57Bl,6J
R990 T3544 T3543 amod comprehensive,panel
R991 T3466 T3464 conj Cara1,Carp1
R992 T3467 T3466 cc and,Cara1
R993 T3468 T3466 conj Feml1,Cara1
R994 T3545 T3543 prep of,panel
R995 T3469 T3466 prep on,Cara1
R996 T3470 T3469 pobj MMU2,on
R997 T3471 T3466 punct ", ",Cara1
R998 T3546 T3547 amod overlapping,strains
R999 T3472 T3466 conj Carfhg1,Cara1