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PMC:1448208 / 6533-7183 JSONTXT 4 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T4200 0-3 DT denotes The
T4201 4-13 NN denotes objective
T4203 14-16 IN denotes of
T4204 17-20 DT denotes the
T4206 21-28 JJ denotes present
T4205 29-34 NN denotes study
T4202 35-38 VBD denotes was
T4207 39-41 TO denotes to
T4208 42-48 VB denotes create
T4209 49-60 RB denotes genetically
T4210 61-71 VBN denotes engineered
T4212 72-78 JJ denotes murine
T4211 79-85 NNS denotes models
T4213 86-88 IN denotes of
T4214 89-93 NN denotes MSUD
T4215 94-98 WDT denotes that
T4216 99-104 VBP denotes mimic
T4217 105-108 DT denotes the
T4218 109-118 NN denotes pathology
T4219 119-121 IN denotes of
T4220 122-125 DT denotes the
T4222 126-133 JJ denotes classic
T4223 134-137 CC denotes and
T4224 138-150 JJ denotes intermediate
T4225 151-158 JJ denotes variant
T4221 159-164 NNS denotes forms
T4226 165-167 IN denotes of
T4227 168-171 DT denotes the
T4229 172-177 JJ denotes human
T4228 178-185 NN denotes disease
T4230 185-186 . denotes .
T4231 186-326 sentence denotes The classic model was created by targeted inactivation of the E2 subunit of BCKDH by homologous recombination in embryonic stem (ES) cells.
T4232 187-190 DT denotes The
T4234 191-198 JJ denotes classic
T4233 199-204 NN denotes model
T4236 205-208 VBD denotes was
T4235 209-216 VBN denotes created
T4237 217-219 IN denotes by
T4238 220-228 VBN denotes targeted
T4239 229-241 NN denotes inactivation
T4240 242-244 IN denotes of
T4241 245-248 DT denotes the
T4243 249-251 NN denotes E2
T4242 252-259 NN denotes subunit
T4244 260-262 IN denotes of
T4245 263-268 NN denotes BCKDH
T4246 269-271 IN denotes by
T4247 272-282 JJ denotes homologous
T4248 283-296 NN denotes recombination
T4249 297-299 IN denotes in
T4250 300-309 JJ denotes embryonic
T4252 310-314 NN denotes stem
T4253 315-316 -LRB- denotes (
T4251 316-318 NN denotes ES
T4255 318-319 -RRB- denotes )
T4254 320-325 NNS denotes cells
T4256 325-326 . denotes .
T4257 326-423 sentence denotes The model of intermediate MSUD was created by partial transgenic rescue of the E2 gene knockout.
T4258 327-330 DT denotes The
T4259 331-336 NN denotes model
T4261 337-339 IN denotes of
T4262 340-352 JJ denotes intermediate
T4263 353-357 NN denotes MSUD
T4264 358-361 VBD denotes was
T4260 362-369 VBN denotes created
T4265 370-372 IN denotes by
T4266 373-380 JJ denotes partial
T4268 381-391 JJ denotes transgenic
T4267 392-398 NN denotes rescue
T4269 399-401 IN denotes of
T4270 402-405 DT denotes the
T4272 406-408 NN denotes E2
T4273 409-413 NN denotes gene
T4271 414-422 NN denotes knockout
T4274 422-423 . denotes .
T4275 423-513 sentence denotes This report describes the generation and characterization of these murine models of MSUD.
T4276 424-428 DT denotes This
T4277 429-435 NN denotes report
T4278 436-445 VBZ denotes describes
T4279 446-449 DT denotes the
T4280 450-460 NN denotes generation
T4281 461-464 CC denotes and
T4282 465-481 NN denotes characterization
T4283 482-484 IN denotes of
T4284 485-490 DT denotes these
T4286 491-497 JJ denotes murine
T4285 498-504 NNS denotes models
T4287 505-507 IN denotes of
T4288 508-512 NN denotes MSUD
T4289 512-513 . denotes .
T4290 513-650 sentence denotes These models will allow for the development of novel treatment approaches, such as gene or stem cell therapies, to ultimately cure MSUD.
T4291 514-519 DT denotes These
T4292 520-526 NNS denotes models
T4294 527-531 MD denotes will
T4293 532-537 VB denotes allow
T4295 538-541 IN denotes for
T4296 542-545 DT denotes the
T4297 546-557 NN denotes development
T4298 558-560 IN denotes of
T4299 561-566 JJ denotes novel
T4301 567-576 NN denotes treatment
T4300 577-587 NNS denotes approaches
T4302 587-589 , denotes ,
T4303 589-593 JJ denotes such
T4304 594-596 IN denotes as
T4305 597-601 NN denotes gene
T4307 602-604 CC denotes or
T4308 605-609 NN denotes stem
T4309 610-614 NN denotes cell
T4306 615-624 NNS denotes therapies
T4310 624-626 , denotes ,
T4311 626-628 TO denotes to
T4313 629-639 RB denotes ultimately
T4312 640-644 VB denotes cure
T4314 645-649 NN denotes MSUD
T4315 649-650 . denotes .
R1111 T4200 T4201 det The,objective
R1113 T4201 T4202 nsubj objective,was
R1114 T4203 T4201 prep of,objective
R1116 T4204 T4205 det the,study
R1117 T4205 T4203 pobj study,of
R1118 T4206 T4205 amod present,study
R1120 T4207 T4208 aux to,create
R1121 T4208 T4202 xcomp create,was
R1122 T4209 T4210 advmod genetically,engineered
R1123 T4210 T4211 amod engineered,models
R1124 T4211 T4208 dobj models,create
R1125 T4212 T4211 amod murine,models
R1127 T4213 T4211 prep of,models
R1128 T4214 T4213 pobj MSUD,of
R1130 T4215 T4216 dep that,mimic
R1131 T4216 T4211 relcl mimic,models
R1132 T4217 T4218 det the,pathology
R1134 T4218 T4216 dobj pathology,mimic
R1135 T4219 T4218 prep of,pathology
R1136 T4220 T4221 det the,forms
R1137 T4221 T4219 pobj forms,of
R1139 T4222 T4221 amod classic,forms
R1140 T4223 T4222 cc and,classic
R1141 T4224 T4222 conj intermediate,classic
R1143 T4225 T4221 amod variant,forms
R1144 T4226 T4221 prep of,forms
R1146 T4227 T4228 det the,disease
R1147 T4228 T4226 pobj disease,of
R1148 T4229 T4228 amod human,disease
R1150 T4230 T4202 punct .,was
R1151 T4232 T4233 det The,model
R1153 T4233 T4235 nsubjpass model,created
R1154 T4234 T4233 amod classic,model
R1156 T4236 T4235 auxpass was,created
R1157 T4237 T4235 prep by,created
R1159 T4238 T4239 amod targeted,inactivation
R1160 T4239 T4237 pobj inactivation,by
R1161 T4240 T4239 prep of,inactivation
R1164 T4241 T4242 det the,subunit
R1166 T4242 T4240 pobj subunit,of
R1167 T4243 T4242 compound E2,subunit
R1169 T4244 T4242 prep of,subunit
R1170 T4245 T4244 pobj BCKDH,of
R1171 T4246 T4239 prep by,inactivation
R1173 T4247 T4248 amod homologous,recombination
R1174 T4248 T4246 pobj recombination,by
R1175 T4249 T4239 prep in,inactivation
R1176 T4250 T4251 nmod embryonic,ES
R1177 T4251 T4254 nmod ES,cells
R1179 T4252 T4251 nmod stem,ES
R1180 T4253 T4251 punct (,ES
R1182 T4254 T4249 pobj cells,in
R1183 T4255 T4254 punct ),cells
R1184 T4256 T4235 punct .,created
R1186 T4258 T4259 det The,model
R1187 T4259 T4260 nsubjpass model,created
R1189 T4261 T4259 prep of,model
R1190 T4262 T4263 amod intermediate,MSUD
R1192 T4263 T4261 pobj MSUD,of
R1193 T4264 T4260 auxpass was,created
R1194 T4265 T4260 prep by,created
R1196 T4266 T4267 amod partial,rescue
R1197 T4267 T4265 pobj rescue,by
R1200 T4268 T4267 amod transgenic,rescue
R1201 T4269 T4267 prep of,rescue
R1203 T4270 T4271 det the,knockout
R1204 T4271 T4269 pobj knockout,of
R1206 T4272 T4271 compound E2,knockout
R1207 T4273 T4271 compound gene,knockout
R1208 T4274 T4260 punct .,created
R1210 T4276 T4277 det This,report
R1211 T4277 T4278 nsubj report,describes
R1213 T4279 T4280 det the,generation
R1214 T4280 T4278 dobj generation,describes
R1215 T4281 T4280 cc and,generation
R1216 T4282 T4280 conj characterization,generation
R1218 T4283 T4280 prep of,generation
R1219 T4284 T4285 det these,models
R1220 T4285 T4283 pobj models,of
R1221 T4286 T4285 amod murine,models
R1223 T4287 T4285 prep of,models
R1224 T4288 T4287 pobj MSUD,of
R1225 T4289 T4278 punct .,describes
R1226 T4291 T4292 det These,models
R1228 T4292 T4293 nsubj models,allow
R1229 T4294 T4293 aux will,allow
R1230 T4295 T4293 prep for,allow
R1232 T4296 T4297 det the,development
R1233 T4297 T4295 pobj development,for
R1234 T4298 T4297 prep of,development
R1236 T4299 T4300 amod novel,approaches
R1237 T4300 T4298 pobj approaches,of
R1238 T4301 T4300 compound treatment,approaches
R1240 T4302 T4300 punct ", ",approaches
R1241 T4303 T4304 amod such,as
R1242 T4304 T4300 prep as,approaches
R1244 T4305 T4306 nmod gene,therapies
R1245 T4306 T4304 pobj therapies,as
R1246 T4307 T4305 cc or,gene
R1248 T4308 T4309 compound stem,cell
R1249 T4309 T4305 conj cell,gene
R1250 T4310 T4293 punct ", ",allow
R1251 T4311 T4312 aux to,cure
R1253 T4312 T4293 advcl cure,allow
R1254 T4313 T4312 advmod ultimately,cure
R1255 T4314 T4312 dobj MSUD,cure
R1257 T4315 T4293 punct .,allow