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PMC:1448208 / 3457-4406 JSONTXT 4 Projects

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Id Subject Object Predicate Lexical cue
T3590 0-3 DT denotes The
T3592 4-9 NN denotes BCKDH
T3591 10-17 NN denotes complex
T3594 17-19 , denotes ,
T3595 19-22 DT denotes the
T3597 23-32 JJ denotes deficient
T3596 33-39 NN denotes enzyme
T3598 40-42 IN denotes in
T3599 43-47 NN denotes MSUD
T3600 47-49 , denotes ,
T3593 49-57 VBZ denotes consists
T3601 58-60 IN denotes of
T3602 61-66 CD denotes three
T3604 67-76 JJ denotes catalytic
T3603 77-85 NN denotes proteins
T3605 85-87 , denotes ,
T3606 87-88 DT denotes a
T3607 89-102 NN denotes decarboxylase
T3608 103-104 -LRB- denotes (
T3609 104-106 NN denotes E1
T3610 106-107 -RRB- denotes )
T3611 107-109 , denotes ,
T3612 109-110 DT denotes a
T3614 111-124 NN denotes dihydrolipoyl
T3613 125-137 NN denotes transacylase
T3615 138-139 -LRB- denotes (
T3616 139-141 NN denotes E2
T3617 141-142 -RRB- denotes )
T3618 142-144 , denotes ,
T3619 144-147 CC denotes and
T3620 148-149 DT denotes a
T3622 150-163 NN denotes dihydrolipoyl
T3621 164-177 NN denotes dehydrogenase
T3623 178-179 -LRB- denotes (
T3624 179-181 NN denotes E3
T3625 181-182 -RRB- denotes )
T3626 182-183 . denotes .
T3627 183-262 sentence denotes The E1 component is a heterotetramer composed of two α and two β subunits [3].
T3628 184-187 DT denotes The
T3630 188-190 NN denotes E1
T3629 191-200 NN denotes component
T3631 201-203 VBZ denotes is
T3632 204-205 DT denotes a
T3633 206-220 NN denotes heterotetramer
T3634 221-229 VBN denotes composed
T3635 230-232 IN denotes of
T3636 233-236 CD denotes two
T3637 237-238 NN denotes α
T3639 239-242 CC denotes and
T3640 243-246 CD denotes two
T3641 247-248 NN denotes β
T3638 249-257 NNS denotes subunits
T3642 258-259 -LRB- denotes [
T3643 259-260 CD denotes 3
T3644 260-261 -RRB- denotes ]
T3645 261-262 . denotes .
T3646 262-431 sentence denotes The E1 and E2 components are specific to BCKDH, whereas E3 is also used by pyruvate and α-ketoglutarate dehydrogenase complexes [3] and the glycine cleavage system [4].
T3647 263-266 DT denotes The
T3649 267-269 NN denotes E1
T3650 270-273 CC denotes and
T3651 274-276 NN denotes E2
T3648 277-287 NNS denotes components
T3652 288-291 VBP denotes are
T3653 292-300 JJ denotes specific
T3654 301-303 IN denotes to
T3655 304-309 NN denotes BCKDH
T3656 309-311 , denotes ,
T3657 311-318 IN denotes whereas
T3659 319-321 NN denotes E3
T3660 322-324 VBZ denotes is
T3661 325-329 RB denotes also
T3658 330-334 VBN denotes used
T3662 335-337 IN denotes by
T3663 338-346 NN denotes pyruvate
T3665 347-350 CC denotes and
T3666 351-352 NN denotes α
T3668 352-353 HYPH denotes -
T3667 353-366 NN denotes ketoglutarate
T3669 367-380 NN denotes dehydrogenase
T3664 381-390 NNS denotes complexes
T3670 391-392 -LRB- denotes [
T3671 392-393 CD denotes 3
T3672 393-394 -RRB- denotes ]
T3673 395-398 CC denotes and
T3674 399-402 DT denotes the
T3676 403-410 NN denotes glycine
T3677 411-419 NN denotes cleavage
T3675 420-426 NN denotes system
T3678 427-428 -LRB- denotes [
T3679 428-429 CD denotes 4
T3680 429-430 -RRB- denotes ]
T3681 430-431 . denotes .
T3682 431-674 sentence denotes BCKDH is also associated with two regulatory proteins, a specific kinase and a phosphatase which regulate the activity of this enzyme through a phosphorylation (inactivation) and dephosphorylation (activation) cycle of the E1 α subunit [5,6].
T3683 432-437 NN denotes BCKDH
T3685 438-440 VBZ denotes is
T3686 441-445 RB denotes also
T3684 446-456 VBN denotes associated
T3687 457-461 IN denotes with
T3688 462-465 CD denotes two
T3690 466-476 JJ denotes regulatory
T3689 477-485 NN denotes proteins
T3691 485-487 , denotes ,
T3692 487-488 DT denotes a
T3694 489-497 JJ denotes specific
T3693 498-504 NN denotes kinase
T3695 505-508 CC denotes and
T3696 509-510 DT denotes a
T3697 511-522 NN denotes phosphatase
T3698 523-528 WDT denotes which
T3699 529-537 VBP denotes regulate
T3700 538-541 DT denotes the
T3701 542-550 NN denotes activity
T3702 551-553 IN denotes of
T3703 554-558 DT denotes this
T3704 559-565 NN denotes enzyme
T3705 566-573 IN denotes through
T3706 574-575 DT denotes a
T3708 576-591 NN denotes phosphorylation
T3709 592-593 -LRB- denotes (
T3710 593-605 NN denotes inactivation
T3711 605-606 -RRB- denotes )
T3712 607-610 CC denotes and
T3713 611-628 NN denotes dephosphorylation
T3714 629-630 -LRB- denotes (
T3715 630-640 NN denotes activation
T3716 640-641 -RRB- denotes )
T3707 642-647 NN denotes cycle
T3717 648-650 IN denotes of
T3718 651-654 DT denotes the
T3720 655-657 NN denotes E1
T3721 658-659 NN denotes α
T3719 660-667 NN denotes subunit
T3722 668-669 -LRB- denotes [
T3724 669-670 CD denotes 5
T3725 670-671 , denotes ,
T3723 671-672 CD denotes 6
T3726 672-673 -RRB- denotes ]
T3727 673-674 . denotes .
T3728 674-842 sentence denotes Mutations in the genes of the E1 and E2 subunits of BCKDH have been described, however, the majority of MSUD mutations identified thus far are in the E2 subunit [1,7].
T3729 675-684 NNS denotes Mutations
T3731 685-687 IN denotes in
T3732 688-691 DT denotes the
T3733 692-697 NNS denotes genes
T3734 698-700 IN denotes of
T3735 701-704 DT denotes the
T3737 705-707 NN denotes E1
T3738 708-711 CC denotes and
T3739 712-714 NN denotes E2
T3736 715-723 NNS denotes subunits
T3740 724-726 IN denotes of
T3741 727-732 NN denotes BCKDH
T3742 733-737 VBP denotes have
T3743 738-742 VBN denotes been
T3730 743-752 VBN denotes described
T3745 752-754 , denotes ,
T3746 754-761 RB denotes however
T3747 761-763 , denotes ,
T3748 763-766 DT denotes the
T3749 767-775 NN denotes majority
T3750 776-778 IN denotes of
T3751 779-783 NN denotes MSUD
T3752 784-793 NNS denotes mutations
T3753 794-804 VBN denotes identified
T3754 805-809 RB denotes thus
T3755 810-813 RB denotes far
T3744 814-817 VBP denotes are
T3756 818-820 IN denotes in
T3757 821-824 DT denotes the
T3759 825-827 NN denotes E2
T3758 828-835 NN denotes subunit
T3760 836-837 -LRB- denotes [
T3762 837-838 CD denotes 1
T3763 838-839 , denotes ,
T3761 839-840 CD denotes 7
T3764 840-841 -RRB- denotes ]
T3765 841-842 . denotes .
T3766 842-949 sentence denotes To date, cases of MSUD have not been associated with defects in the regulatory kinase and phosphatase [1].
T3767 843-845 IN denotes To
T3769 846-850 NN denotes date
T3770 850-852 , denotes ,
T3771 852-857 NNS denotes cases
T3772 858-860 IN denotes of
T3773 861-865 NN denotes MSUD
T3774 866-870 VBP denotes have
T3775 871-874 RB denotes not
T3776 875-879 VBN denotes been
T3768 880-890 VBN denotes associated
T3777 891-895 IN denotes with
T3778 896-903 NNS denotes defects
T3779 904-906 IN denotes in
T3780 907-910 DT denotes the
T3782 911-921 JJ denotes regulatory
T3781 922-928 NN denotes kinase
T3783 929-932 CC denotes and
T3784 933-944 NN denotes phosphatase
T3785 945-946 -LRB- denotes [
T3786 946-947 CD denotes 1
T3787 947-948 -RRB- denotes ]
T3788 948-949 . denotes .
R595 T3590 T3591 det The,complex
R597 T3591 T3593 nsubj complex,consists
R598 T3592 T3591 compound BCKDH,complex
R599 T3594 T3591 punct ", ",complex
R600 T3595 T3596 det the,enzyme
R601 T3596 T3591 appos enzyme,complex
R603 T3597 T3596 amod deficient,enzyme
R604 T3598 T3596 prep in,enzyme
R605 T3599 T3598 pobj MSUD,in
R606 T3600 T3593 punct ", ",consists
R607 T3601 T3593 prep of,consists
R609 T3602 T3603 nummod three,proteins
R610 T3603 T3601 pobj proteins,of
R611 T3604 T3603 amod catalytic,proteins
R613 T3605 T3603 punct ", ",proteins
R614 T3606 T3607 det a,decarboxylase
R615 T3607 T3603 appos decarboxylase,proteins
R617 T3608 T3609 punct (,E1
R618 T3609 T3607 parataxis E1,decarboxylase
R619 T3610 T3609 punct ),E1
R621 T3611 T3607 punct ", ",decarboxylase
R622 T3612 T3613 det a,transacylase
R624 T3613 T3607 conj transacylase,decarboxylase
R625 T3614 T3613 compound dihydrolipoyl,transacylase
R626 T3615 T3616 punct (,E2
R628 T3616 T3613 parataxis E2,transacylase
R629 T3617 T3616 punct ),E2
R630 T3618 T3613 punct ", ",transacylase
R632 T3619 T3613 cc and,transacylase
R633 T3620 T3621 det a,dehydrogenase
R634 T3621 T3613 conj dehydrogenase,transacylase
R635 T3622 T3621 compound dihydrolipoyl,dehydrogenase
R637 T3623 T3624 punct (,E3
R638 T3624 T3621 parataxis E3,dehydrogenase
R639 T3625 T3624 punct ),E3
R641 T3626 T3593 punct .,consists
R643 T3628 T3629 det The,component
R644 T3629 T3631 nsubj component,is
R645 T3630 T3629 compound E1,component
R647 T3632 T3633 det a,heterotetramer
R648 T3633 T3631 attr heterotetramer,is
R651 T3634 T3633 acl composed,heterotetramer
R653 T3635 T3634 prep of,composed
R654 T3636 T3637 nummod two,α
R655 T3637 T3638 nmod α,subunits
R657 T3638 T3635 pobj subunits,of
R658 T3639 T3637 cc and,α
R660 T3640 T3641 nummod two,β
R661 T3641 T3637 conj β,α
R662 T3642 T3643 punct [,3
R664 T3643 T3631 parataxis 3,is
R665 T3644 T3643 punct ],3
R666 T3645 T3631 punct .,is
R668 T3647 T3648 det The,components
R670 T3648 T3652 nsubj components,are
R671 T3649 T3648 nmod E1,components
R672 T3650 T3649 cc and,E1
R673 T3739 T3737 conj E2,E1
R674 T3651 T3649 conj E2,E1
R675 T3653 T3652 acomp specific,are
R676 T3654 T3653 prep to,specific
R677 T3655 T3654 pobj BCKDH,to
R678 T3740 T3736 prep of,subunits
R679 T3656 T3652 punct ", ",are
R680 T3657 T3658 mark whereas,used
R681 T3658 T3652 advcl used,are
R682 T3741 T3740 pobj BCKDH,of
R683 T3659 T3658 nsubjpass E3,used
R684 T3660 T3658 auxpass is,used
R685 T3661 T3658 advmod also,used
R686 T3742 T3730 aux have,described
R687 T3662 T3658 agent by,used
R688 T3663 T3664 nmod pyruvate,complexes
R689 T3664 T3662 pobj complexes,by
R690 T3743 T3730 auxpass been,described
R691 T3665 T3663 cc and,pyruvate
R692 T3666 T3667 compound α,ketoglutarate
R693 T3745 T3744 punct ", ",are
R694 T3667 T3663 conj ketoglutarate,pyruvate
R695 T3668 T3667 punct -,ketoglutarate
R696 T3669 T3664 compound dehydrogenase,complexes
R697 T3670 T3671 punct [,3
R698 T3671 T3664 parataxis 3,complexes
R699 T3746 T3744 advmod however,are
R700 T3672 T3671 punct ],3
R701 T3673 T3664 cc and,complexes
R702 T3674 T3675 det the,system
R703 T3675 T3664 conj system,complexes
R704 T3676 T3677 compound glycine,cleavage
R705 T3677 T3675 compound cleavage,system
R706 T3678 T3679 punct [,4
R707 T3747 T3744 punct ", ",are
R708 T3679 T3675 parataxis 4,system
R709 T3680 T3679 punct ],4
R710 T3681 T3652 punct .,are
R711 T3748 T3749 det the,majority
R712 T3683 T3684 nsubjpass BCKDH,associated
R713 T3749 T3744 nsubj majority,are
R714 T3685 T3684 auxpass is,associated
R715 T3686 T3684 advmod also,associated
R716 T3750 T3749 prep of,majority
R717 T3687 T3684 prep with,associated
R718 T3688 T3689 nummod two,proteins
R719 T3689 T3687 pobj proteins,with
R720 T3751 T3752 compound MSUD,mutations
R721 T3690 T3689 amod regulatory,proteins
R722 T3691 T3689 punct ", ",proteins
R723 T3692 T3693 det a,kinase
R724 T3693 T3689 appos kinase,proteins
R725 T3752 T3750 pobj mutations,of
R726 T3694 T3693 amod specific,kinase
R727 T3695 T3693 cc and,kinase
R728 T3753 T3752 acl identified,mutations
R729 T3696 T3697 det a,phosphatase
R730 T3697 T3693 conj phosphatase,kinase
R731 T3698 T3699 dep which,regulate
R732 T3699 T3689 relcl regulate,proteins
R733 T3754 T3755 advmod thus,far
R734 T3700 T3701 det the,activity
R735 T3701 T3699 dobj activity,regulate
R736 T3702 T3701 prep of,activity
R737 T3755 T3753 advmod far,identified
R738 T3703 T3704 det this,enzyme
R739 T3704 T3702 pobj enzyme,of
R740 T3705 T3699 prep through,regulate
R741 T3756 T3744 prep in,are
R742 T3706 T3707 det a,cycle
R743 T3707 T3705 pobj cycle,through
R744 T3757 T3758 det the,subunit
R745 T3708 T3707 nmod phosphorylation,cycle
R746 T3709 T3710 punct (,inactivation
R747 T3710 T3708 parataxis inactivation,phosphorylation
R748 T3758 T3756 pobj subunit,in
R749 T3711 T3710 punct ),inactivation
R750 T3712 T3708 cc and,phosphorylation
R751 T3713 T3708 conj dephosphorylation,phosphorylation
R752 T3759 T3758 compound E2,subunit
R753 T3714 T3715 punct (,activation
R754 T3715 T3713 parataxis activation,dephosphorylation
R755 T3716 T3715 punct ),activation
R756 T3717 T3707 prep of,cycle
R757 T3718 T3719 det the,subunit
R758 T3719 T3717 pobj subunit,of
R759 T3760 T3761 punct [,7
R760 T3720 T3719 compound E1,subunit
R761 T3721 T3719 compound α,subunit
R762 T3722 T3723 punct [,6
R763 T3761 T3744 parataxis 7,are
R764 T3723 T3684 parataxis 6,associated
R765 T3762 T3761 nummod 1,7
R766 T3724 T3723 nummod 5,6
R767 T3725 T3723 punct ",",6
R768 T3726 T3723 punct ],6
R769 T3763 T3761 punct ",",7
R770 T3727 T3684 punct .,associated
R771 T3764 T3761 punct ],7
R772 T3765 T3744 punct .,are
R773 T3767 T3768 prep To,associated
R774 T3729 T3730 nsubjpass Mutations,described
R775 T3730 T3744 ccomp described,are
R776 T3731 T3729 prep in,Mutations
R777 T3769 T3767 pobj date,To
R778 T3732 T3733 det the,genes
R779 T3733 T3731 pobj genes,in
R780 T3734 T3733 prep of,genes
R781 T3735 T3736 det the,subunits
R782 T3770 T3768 punct ", ",associated
R783 T3736 T3734 pobj subunits,of
R784 T3737 T3736 nmod E1,subunits
R785 T3738 T3737 cc and,E1
R786 T3771 T3768 nsubjpass cases,associated
R787 T3772 T3771 prep of,cases
R788 T3773 T3772 pobj MSUD,of
R790 T3774 T3768 aux have,associated
R793 T3775 T3768 neg not,associated
R797 T3776 T3768 auxpass been,associated
R800 T3777 T3768 prep with,associated
R803 T3778 T3777 pobj defects,with
R810 T3779 T3778 prep in,defects
R815 T3780 T3781 det the,kinase
R819 T3781 T3779 pobj kinase,in
R823 T3782 T3781 amod regulatory,kinase
R825 T3783 T3781 cc and,kinase
R828 T3784 T3781 conj phosphatase,kinase
R832 T3785 T3786 punct [,1
R836 T3786 T3768 parataxis 1,associated
R840 T3787 T3786 punct ],1
R844 T3788 T3768 punct .,associated