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PMC:1440874 / 6836-8116 JSONTXT 5 Projects

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Id Subject Object Predicate Lexical cue
T1584 0-4 IN denotes Like
T1586 5-8 DT denotes the
T1588 9-14 JJ denotes human
T1587 15-19 NN denotes gene
T1589 19-21 , denotes ,
T1590 21-24 DT denotes the
T1592 25-30 NN denotes mouse
T1593 31-35 NN denotes Atrx
T1591 36-40 NN denotes gene
T1585 41-43 VBZ denotes is
T1594 44-48 RB denotes also
T1595 49-50 NN denotes X
T1597 50-51 HYPH denotes -
T1596 51-57 VBN denotes linked
T1598 57-59 , denotes ,
T1599 59-63 JJ denotes such
T1601 64-68 IN denotes that
T1602 69-70 DT denotes a
T1604 71-77 JJ denotes direct
T1603 78-88 NN denotes disruption
T1605 89-91 IN denotes of
T1606 92-95 DT denotes the
T1608 96-102 JJ denotes single
T1609 103-107 NN denotes Atrx
T1607 108-114 NN denotes allele
T1610 115-117 IN denotes in
T1611 118-122 JJ denotes male
T1613 123-125 NN denotes ES
T1612 126-131 NNS denotes cells
T1614 132-137 MD denotes would
T1615 138-149 RB denotes immediately
T1600 150-154 VB denotes give
T1616 155-159 NN denotes rise
T1617 160-162 IN denotes to
T1618 163-166 DT denotes the
T1620 167-171 JJ denotes null
T1619 172-177 NN denotes state
T1621 177-178 . denotes .
T1622 178-345 sentence denotes No targeted clones were recovered after attempted homologous recombination in male E14TG2a ES cells using two different vectors that removed exon 18 of the Atrx gene.
T1623 179-181 DT denotes No
T1625 182-190 VBN denotes targeted
T1624 191-197 NNS denotes clones
T1627 198-202 VBD denotes were
T1626 203-212 VBN denotes recovered
T1628 213-218 IN denotes after
T1629 219-228 VBN denotes attempted
T1631 229-239 JJ denotes homologous
T1630 240-253 NN denotes recombination
T1632 254-256 IN denotes in
T1633 257-261 JJ denotes male
T1635 262-269 NN denotes E14TG2a
T1636 270-272 NN denotes ES
T1634 273-278 NNS denotes cells
T1637 279-284 VBG denotes using
T1638 285-288 CD denotes two
T1640 289-298 JJ denotes different
T1639 299-306 NNS denotes vectors
T1641 307-311 WDT denotes that
T1642 312-319 VBD denotes removed
T1643 320-324 NN denotes exon
T1644 325-327 CD denotes 18
T1645 328-330 IN denotes of
T1646 331-334 DT denotes the
T1648 335-339 NN denotes Atrx
T1647 340-344 NN denotes gene
T1649 344-345 . denotes .
T1650 345-588 sentence denotes Exon 18 encodes the first of the seven motifs composing the conserved SNF2-like domain of Atrx (Figure 1); mutation of the corresponding motif of the yeast SNF2 protein has been shown to severely impair SWI/SNF-dependent gene expression [12].
T1651 346-350 NN denotes Exon
T1653 351-353 CD denotes 18
T1652 354-361 VBZ denotes encodes
T1655 362-365 DT denotes the
T1656 366-371 JJ denotes first
T1657 372-374 IN denotes of
T1658 375-378 DT denotes the
T1660 379-384 CD denotes seven
T1659 385-391 NNS denotes motifs
T1661 392-401 VBG denotes composing
T1662 402-405 DT denotes the
T1664 406-415 VBN denotes conserved
T1665 416-420 NN denotes SNF2
T1667 420-421 HYPH denotes -
T1666 421-425 JJ denotes like
T1663 426-432 NN denotes domain
T1668 433-435 IN denotes of
T1669 436-440 NN denotes Atrx
T1670 441-442 -LRB- denotes (
T1671 442-448 NN denotes Figure
T1672 449-450 CD denotes 1
T1673 450-451 -RRB- denotes )
T1674 451-452 : denotes ;
T1675 453-461 NN denotes mutation
T1676 462-464 IN denotes of
T1677 465-468 DT denotes the
T1679 469-482 VBG denotes corresponding
T1678 483-488 NN denotes motif
T1680 489-491 IN denotes of
T1681 492-495 DT denotes the
T1683 496-501 NN denotes yeast
T1684 502-506 NN denotes SNF2
T1682 507-514 NN denotes protein
T1685 515-518 VBZ denotes has
T1686 519-523 VBN denotes been
T1654 524-529 VBN denotes shown
T1687 530-532 TO denotes to
T1689 533-541 RB denotes severely
T1688 542-548 VB denotes impair
T1690 549-552 NN denotes SWI
T1692 552-553 HYPH denotes /
T1691 553-556 NN denotes SNF
T1694 556-557 HYPH denotes -
T1693 557-566 JJ denotes dependent
T1696 567-571 NN denotes gene
T1695 572-582 NN denotes expression
T1697 583-584 -LRB- denotes [
T1698 584-586 CD denotes 12
T1699 586-587 -RRB- denotes ]
T1700 587-588 . denotes .
T1701 588-790 sentence denotes The failure to recover targeted clones with these vectors suggested that Atrx may be important for normal ES cell growth and expansion and that direct targeting of the single locus may not be possible.
T1702 589-592 DT denotes The
T1703 593-600 NN denotes failure
T1705 601-603 TO denotes to
T1706 604-611 VB denotes recover
T1707 612-620 VBN denotes targeted
T1708 621-627 NNS denotes clones
T1709 628-632 IN denotes with
T1710 633-638 DT denotes these
T1711 639-646 NNS denotes vectors
T1704 647-656 VBD denotes suggested
T1712 657-661 IN denotes that
T1714 662-666 NN denotes Atrx
T1715 667-670 MD denotes may
T1713 671-673 VB denotes be
T1716 674-683 JJ denotes important
T1717 684-687 IN denotes for
T1718 688-694 JJ denotes normal
T1720 695-697 NN denotes ES
T1719 698-702 NN denotes cell
T1721 703-709 NN denotes growth
T1722 710-713 CC denotes and
T1723 714-723 NN denotes expansion
T1724 724-727 CC denotes and
T1725 728-732 IN denotes that
T1727 733-739 JJ denotes direct
T1728 740-749 NN denotes targeting
T1729 750-752 IN denotes of
T1730 753-756 DT denotes the
T1732 757-763 JJ denotes single
T1731 764-769 NN denotes locus
T1733 770-773 MD denotes may
T1734 774-777 RB denotes not
T1726 778-780 VB denotes be
T1735 781-789 JJ denotes possible
T1736 789-790 . denotes .
T1737 790-1021 sentence denotes We therefore adopted a conditional strategy for targeting exon 18 (Figure 2) and recovered two clones in which exon 18 has been flanked by loxP recognition sites for the Cre recombinase (Atrx flox allele in Figure 2A) (Figure 2B).
T1738 791-793 PRP denotes We
T1740 794-803 RB denotes therefore
T1739 804-811 VBD denotes adopted
T1741 812-813 DT denotes a
T1743 814-825 JJ denotes conditional
T1742 826-834 NN denotes strategy
T1744 835-838 IN denotes for
T1745 839-848 VBG denotes targeting
T1746 849-853 NN denotes exon
T1747 854-856 CD denotes 18
T1748 857-858 -LRB- denotes (
T1749 858-864 NN denotes Figure
T1750 865-866 CD denotes 2
T1751 866-867 -RRB- denotes )
T1752 868-871 CC denotes and
T1753 872-881 VBD denotes recovered
T1754 882-885 CD denotes two
T1755 886-892 NNS denotes clones
T1756 893-895 IN denotes in
T1758 896-901 WDT denotes which
T1759 902-906 NN denotes exon
T1760 907-909 CD denotes 18
T1761 910-913 VBZ denotes has
T1762 914-918 VBN denotes been
T1757 919-926 VBN denotes flanked
T1763 927-929 IN denotes by
T1764 930-934 NN denotes loxP
T1766 935-946 NN denotes recognition
T1765 947-952 NNS denotes sites
T1767 953-956 IN denotes for
T1768 957-960 DT denotes the
T1770 961-964 NN denotes Cre
T1769 965-976 NN denotes recombinase
T1771 977-978 -LRB- denotes (
T1773 978-987 NN denotes Atrx flox
T1772 988-994 NN denotes allele
T1774 995-997 IN denotes in
T1775 998-1004 NN denotes Figure
T1776 1005-1007 NN denotes 2A
T1777 1007-1008 -RRB- denotes )
T1778 1009-1010 -LRB- denotes (
T1780 1010-1016 NN denotes Figure
T1779 1017-1019 NN denotes 2B
T1781 1019-1020 -RRB- denotes )
T1782 1020-1021 . denotes .
T1783 1021-1106 sentence denotes This allele also contains a loxP-flanked MC1-neor cassette in intron 17 (Figure 2A).
T1784 1022-1026 DT denotes This
T1785 1027-1033 NN denotes allele
T1787 1034-1038 RB denotes also
T1786 1039-1047 VBZ denotes contains
T1788 1048-1049 DT denotes a
T1790 1050-1054 NN denotes loxP
T1792 1054-1055 HYPH denotes -
T1791 1055-1062 VBN denotes flanked
T1793 1063-1066 NN denotes MC1
T1795 1066-1067 HYPH denotes -
T1794 1067-1071 NN denotes neor
T1789 1072-1080 NN denotes cassette
T1796 1081-1083 IN denotes in
T1797 1084-1090 NN denotes intron
T1798 1091-1093 CD denotes 17
T1799 1094-1095 -LRB- denotes (
T1801 1095-1101 NN denotes Figure
T1800 1102-1104 NN denotes 2A
T1802 1104-1105 -RRB- denotes )
T1803 1105-1106 . denotes .
T1804 1106-1280 sentence denotes Northern and Western blot analyses (Figure 2D and 2E) confirmed that the Atrx flox clones continued to express both full-length Atrx protein and the truncated Atrxt isoform.
T1805 1107-1115 NNP denotes Northern
T1807 1116-1119 CC denotes and
T1808 1120-1127 NNP denotes Western
T1806 1128-1132 NN denotes blot
T1809 1133-1141 NNS denotes analyses
T1811 1142-1143 -LRB- denotes (
T1813 1143-1149 NN denotes Figure
T1812 1150-1152 NN denotes 2D
T1814 1153-1156 CC denotes and
T1815 1157-1159 NN denotes 2E
T1816 1159-1160 -RRB- denotes )
T1810 1161-1170 VBD denotes confirmed
T1817 1171-1175 IN denotes that
T1819 1176-1179 DT denotes the
T1821 1180-1189 NN denotes Atrx flox
T1820 1190-1196 NNS denotes clones
T1818 1197-1206 VBD denotes continued
T1822 1207-1209 TO denotes to
T1823 1210-1217 VB denotes express
T1824 1218-1222 CC denotes both
T1826 1223-1227 JJ denotes full
T1828 1227-1228 HYPH denotes -
T1827 1228-1234 NN denotes length
T1829 1235-1239 NN denotes Atrx
T1825 1240-1247 NN denotes protein
T1830 1248-1251 CC denotes and
T1831 1252-1255 DT denotes the
T1833 1256-1265 VBN denotes truncated
T1834 1266-1271 NN denotes Atrxt
T1832 1272-1279 NN denotes isoform
T1835 1279-1280 . denotes .
R1000 T1755 T1753 dobj clones,recovered
R1001 T1756 T1757 prep in,flanked
R1002 T1757 T1755 relcl flanked,clones
R1003 T1758 T1756 pobj which,in
R1004 T1759 T1757 nsubjpass exon,flanked
R1005 T1760 T1759 nummod 18,exon
R1006 T1761 T1757 aux has,flanked
R1007 T1762 T1757 auxpass been,flanked
R1008 T1763 T1757 agent by,flanked
R1009 T1764 T1765 compound loxP,sites
R1010 T1765 T1763 pobj sites,by
R1011 T1766 T1765 compound recognition,sites
R1012 T1767 T1765 prep for,sites
R1013 T1768 T1769 det the,recombinase
R1014 T1769 T1767 pobj recombinase,for
R1015 T1770 T1769 compound Cre,recombinase
R1016 T1771 T1772 punct (,allele
R1017 T1772 T1769 parataxis allele,recombinase
R1018 T1773 T1772 compound Atrx flox,allele
R1019 T1774 T1772 prep in,allele
R1020 T1775 T1776 compound Figure,2A
R1021 T1776 T1774 pobj 2A,in
R1022 T1777 T1772 punct ),allele
R1023 T1778 T1779 punct (,2B
R1024 T1779 T1753 parataxis 2B,recovered
R1025 T1780 T1779 compound Figure,2B
R1026 T1781 T1779 punct ),2B
R1027 T1782 T1739 punct .,adopted
R1028 T1784 T1785 det This,allele
R1029 T1785 T1786 nsubj allele,contains
R1030 T1787 T1786 advmod also,contains
R1031 T1788 T1789 det a,cassette
R1032 T1789 T1786 dobj cassette,contains
R1033 T1790 T1791 npadvmod loxP,flanked
R1034 T1791 T1789 amod flanked,cassette
R1035 T1792 T1791 punct -,flanked
R1036 T1793 T1794 compound MC1,neor
R1037 T1794 T1789 compound neor,cassette
R1038 T1795 T1794 punct -,neor
R1039 T1796 T1786 prep in,contains
R1040 T1797 T1796 pobj intron,in
R1041 T1798 T1797 nummod 17,intron
R1042 T1799 T1800 punct (,2A
R1043 T1800 T1786 parataxis 2A,contains
R1044 T1801 T1800 compound Figure,2A
R1045 T1802 T1800 punct ),2A
R1046 T1803 T1786 punct .,contains
R1047 T1805 T1806 nmod Northern,blot
R1048 T1806 T1809 compound blot,analyses
R1049 T1807 T1805 cc and,Northern
R1050 T1808 T1805 conj Western,Northern
R1051 T1809 T1810 nsubj analyses,confirmed
R1052 T1811 T1812 punct (,2D
R1053 T1812 T1809 parataxis 2D,analyses
R1054 T1813 T1812 compound Figure,2D
R1055 T1814 T1812 cc and,2D
R1056 T1815 T1812 conj 2E,2D
R1057 T1816 T1812 punct ),2D
R1058 T1817 T1818 mark that,continued
R1059 T1818 T1810 ccomp continued,confirmed
R1060 T1819 T1820 det the,clones
R1061 T1820 T1818 nsubj clones,continued
R1062 T1821 T1820 compound Atrx flox,clones
R1063 T1822 T1823 aux to,express
R1064 T1823 T1818 xcomp express,continued
R1065 T1824 T1825 preconj both,protein
R1066 T1825 T1823 dobj protein,express
R1067 T1826 T1827 amod full,length
R1068 T1827 T1825 compound length,protein
R1069 T1828 T1827 punct -,length
R1070 T1829 T1825 compound Atrx,protein
R1071 T1830 T1825 cc and,protein
R1072 T1831 T1832 det the,isoform
R1073 T1832 T1825 conj isoform,protein
R1074 T1833 T1832 amod truncated,isoform
R1075 T1834 T1832 compound Atrxt,isoform
R1076 T1835 T1810 punct .,confirmed
R838 T1584 T1585 prep Like,is
R839 T1586 T1587 det the,gene
R840 T1587 T1584 pobj gene,Like
R841 T1588 T1587 amod human,gene
R842 T1589 T1585 punct ", ",is
R843 T1590 T1591 det the,gene
R844 T1591 T1585 nsubj gene,is
R845 T1592 T1591 compound mouse,gene
R846 T1593 T1591 compound Atrx,gene
R847 T1594 T1585 advmod also,is
R848 T1595 T1596 npadvmod X,linked
R849 T1596 T1585 acomp linked,is
R850 T1597 T1596 punct -,linked
R851 T1598 T1585 punct ", ",is
R852 T1599 T1600 amod such,give
R853 T1600 T1585 advcl give,is
R854 T1601 T1600 mark that,give
R855 T1602 T1603 det a,disruption
R856 T1603 T1600 nsubj disruption,give
R857 T1604 T1603 amod direct,disruption
R858 T1605 T1603 prep of,disruption
R859 T1606 T1607 det the,allele
R860 T1607 T1605 pobj allele,of
R861 T1608 T1607 amod single,allele
R862 T1609 T1607 compound Atrx,allele
R863 T1610 T1603 prep in,disruption
R864 T1611 T1612 amod male,cells
R865 T1612 T1610 pobj cells,in
R866 T1613 T1612 compound ES,cells
R867 T1614 T1600 aux would,give
R868 T1615 T1600 advmod immediately,give
R869 T1616 T1600 dobj rise,give
R870 T1617 T1600 prep to,give
R871 T1618 T1619 det the,state
R872 T1619 T1617 pobj state,to
R873 T1620 T1619 amod null,state
R874 T1621 T1585 punct .,is
R875 T1623 T1624 det No,clones
R876 T1624 T1626 nsubjpass clones,recovered
R877 T1625 T1624 amod targeted,clones
R878 T1627 T1626 auxpass were,recovered
R879 T1628 T1626 prep after,recovered
R880 T1629 T1630 amod attempted,recombination
R881 T1630 T1628 pobj recombination,after
R882 T1631 T1630 amod homologous,recombination
R883 T1632 T1630 prep in,recombination
R884 T1633 T1634 amod male,cells
R885 T1634 T1632 pobj cells,in
R886 T1635 T1636 compound E14TG2a,ES
R887 T1636 T1634 compound ES,cells
R888 T1637 T1626 advcl using,recovered
R889 T1638 T1639 nummod two,vectors
R890 T1639 T1637 dobj vectors,using
R891 T1640 T1639 amod different,vectors
R892 T1641 T1642 dep that,removed
R893 T1642 T1639 relcl removed,vectors
R894 T1643 T1642 dobj exon,removed
R895 T1644 T1643 nummod 18,exon
R896 T1645 T1643 prep of,exon
R897 T1646 T1647 det the,gene
R898 T1647 T1645 pobj gene,of
R899 T1648 T1647 compound Atrx,gene
R900 T1649 T1626 punct .,recovered
R901 T1651 T1652 nsubj Exon,encodes
R902 T1652 T1654 ccomp encodes,shown
R903 T1653 T1651 nummod 18,Exon
R904 T1655 T1656 det the,first
R905 T1656 T1652 dobj first,encodes
R906 T1657 T1656 prep of,first
R907 T1658 T1659 det the,motifs
R908 T1659 T1657 pobj motifs,of
R909 T1660 T1659 nummod seven,motifs
R910 T1661 T1656 acl composing,first
R911 T1662 T1663 det the,domain
R912 T1663 T1661 dobj domain,composing
R913 T1664 T1663 amod conserved,domain
R914 T1665 T1666 npadvmod SNF2,like
R915 T1666 T1663 amod like,domain
R916 T1667 T1666 punct -,like
R917 T1668 T1663 prep of,domain
R918 T1669 T1668 pobj Atrx,of
R919 T1670 T1671 punct (,Figure
R920 T1671 T1652 parataxis Figure,encodes
R921 T1672 T1671 nummod 1,Figure
R922 T1673 T1671 punct ),Figure
R923 T1674 T1654 punct ;,shown
R924 T1675 T1654 nsubjpass mutation,shown
R925 T1676 T1675 prep of,mutation
R926 T1677 T1678 det the,motif
R927 T1678 T1676 pobj motif,of
R928 T1679 T1678 amod corresponding,motif
R929 T1680 T1678 prep of,motif
R930 T1681 T1682 det the,protein
R931 T1682 T1680 pobj protein,of
R932 T1683 T1682 compound yeast,protein
R933 T1684 T1682 compound SNF2,protein
R934 T1685 T1654 aux has,shown
R935 T1686 T1654 auxpass been,shown
R936 T1687 T1688 aux to,impair
R937 T1688 T1654 xcomp impair,shown
R938 T1689 T1688 advmod severely,impair
R939 T1690 T1691 compound SWI,SNF
R940 T1691 T1693 npadvmod SNF,dependent
R941 T1692 T1691 punct /,SNF
R942 T1693 T1695 amod dependent,expression
R943 T1694 T1693 punct -,dependent
R944 T1695 T1688 dobj expression,impair
R945 T1696 T1695 compound gene,expression
R946 T1697 T1698 punct [,12
R947 T1698 T1654 parataxis 12,shown
R948 T1699 T1698 punct ],12
R949 T1700 T1654 punct .,shown
R950 T1702 T1703 det The,failure
R951 T1703 T1704 nsubj failure,suggested
R952 T1705 T1706 aux to,recover
R953 T1706 T1703 acl recover,failure
R954 T1707 T1708 amod targeted,clones
R955 T1708 T1706 dobj clones,recover
R956 T1709 T1706 prep with,recover
R957 T1710 T1711 det these,vectors
R958 T1711 T1709 pobj vectors,with
R959 T1712 T1713 mark that,be
R960 T1713 T1704 advcl be,suggested
R961 T1714 T1713 nsubj Atrx,be
R962 T1715 T1713 aux may,be
R963 T1716 T1713 acomp important,be
R964 T1717 T1716 prep for,important
R965 T1718 T1719 amod normal,cell
R966 T1719 T1717 pobj cell,for
R967 T1720 T1719 compound ES,cell
R968 T1721 T1719 appos growth,cell
R969 T1722 T1721 cc and,growth
R970 T1723 T1721 conj expansion,growth
R971 T1724 T1713 cc and,be
R972 T1725 T1726 mark that,be
R973 T1726 T1713 conj be,be
R974 T1727 T1728 amod direct,targeting
R975 T1728 T1726 nsubj targeting,be
R976 T1729 T1728 prep of,targeting
R977 T1730 T1731 det the,locus
R978 T1731 T1729 pobj locus,of
R979 T1732 T1731 amod single,locus
R980 T1733 T1726 aux may,be
R981 T1734 T1726 neg not,be
R982 T1735 T1726 acomp possible,be
R983 T1736 T1704 punct .,suggested
R984 T1738 T1739 nsubj We,adopted
R985 T1740 T1739 advmod therefore,adopted
R986 T1741 T1742 det a,strategy
R987 T1742 T1739 dobj strategy,adopted
R988 T1743 T1742 amod conditional,strategy
R989 T1744 T1742 prep for,strategy
R990 T1745 T1744 pcomp targeting,for
R991 T1746 T1745 dobj exon,targeting
R992 T1747 T1746 nummod 18,exon
R993 T1748 T1749 punct (,Figure
R994 T1749 T1739 parataxis Figure,adopted
R995 T1750 T1749 nummod 2,Figure
R996 T1751 T1749 punct ),Figure
R997 T1752 T1739 cc and,adopted
R998 T1753 T1739 conj recovered,adopted
R999 T1754 T1755 nummod two,clones