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PMC:1440874 / 10404-11597 JSONTXT 5 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T1837 0-2 TO denotes To
T1838 3-11 VB denotes generate
T1840 12-15 DT denotes the
T1842 16-20 JJ denotes full
T1841 21-29 NN denotes deletion
T1843 30-32 IN denotes in
T1844 33-35 NN denotes ES
T1845 36-41 NNS denotes cells
T1846 41-43 , denotes ,
T1847 43-46 DT denotes the
T1849 47-56 NN denotes Atrx flox
T1848 57-63 NNS denotes clones
T1850 64-65 -LRB- denotes (
T1852 65-66 CD denotes 1
T1853 66-67 HYPH denotes /
T1851 67-70 NN denotes F12
T1854 71-74 CC denotes and
T1855 75-76 CD denotes 1
T1857 76-77 HYPH denotes /
T1856 77-80 NN denotes G11
T1858 80-81 -RRB- denotes )
T1859 82-86 VBD denotes were
T1860 87-98 RB denotes transiently
T1839 99-110 VBN denotes transfected
T1861 111-115 IN denotes with
T1862 116-117 DT denotes a
T1864 118-121 NN denotes Cre
T1866 121-122 HYPH denotes -
T1865 122-133 NN denotes recombinase
T1867 134-144 NN denotes expression
T1863 145-152 NN denotes plasmid
T1868 153-154 -LRB- denotes (
T1869 154-160 NN denotes pCAGGS
T1871 160-161 HYPH denotes -
T1872 161-164 NN denotes Cre
T1873 164-165 HYPH denotes -
T1870 165-173 NN denotes IRESpuro
T1874 173-174 -RRB- denotes )
T1875 174-176 , denotes ,
T1876 176-179 CC denotes and
T1877 180-189 NNS denotes subclones
T1879 190-194 VBD denotes were
T1880 195-204 VBN denotes recovered
T1878 205-212 VBG denotes bearing
T1881 213-215 DT denotes an
T1882 216-222 NN denotes allele
T1883 223-224 -LRB- denotes (
T1884 224-236 NN denotes Atrx Δ18Δneo
T1885 237-239 IN denotes in
T1886 240-246 NN denotes Figure
T1887 247-249 NN denotes 2A
T1888 249-250 -RRB- denotes )
T1889 251-253 IN denotes in
T1891 254-259 WDT denotes which
T1892 260-264 CC denotes both
T1893 265-269 NN denotes exon
T1894 270-272 CD denotes 18
T1895 273-276 CC denotes and
T1896 277-280 DT denotes the
T1898 281-285 NN denotes neor
T1897 286-294 NN denotes cassette
T1899 295-298 VBD denotes had
T1900 299-303 VBN denotes been
T1890 304-311 VBN denotes deleted
T1901 312-314 IN denotes by
T1902 315-318 DT denotes the
T1904 319-322 NN denotes Cre
T1903 323-334 NN denotes recombinase
T1905 335-336 -LRB- denotes (
T1906 336-345 VBG denotes resulting
T1907 346-350 IN denotes from
T1908 351-354 DT denotes the
T1910 355-368 NN denotes recombination
T1909 369-374 NN denotes event
T1911 375-383 VBN denotes labelled
T1912 384-385 `` denotes “
T1913 385-386 NN denotes C
T1914 386-387 '' denotes ”
T1915 388-390 IN denotes in
T1916 391-394 DT denotes the
T1918 395-404 NN denotes Atrx flox
T1917 405-411 NN denotes allele
T1919 412-417 VBN denotes shown
T1920 418-420 IN denotes in
T1921 421-427 NN denotes Figure
T1922 428-430 NN denotes 2A
T1923 430-431 -RRB- denotes )
T1924 432-433 -LRB- denotes (
T1926 433-439 NN denotes Figure
T1925 440-442 NN denotes 2C
T1927 442-443 -RRB- denotes )
T1928 443-444 . denotes .
T1929 444-725 sentence denotes Northern and Western blot analyses (Figure 2D and 2E) revealed that the full-length Atrx transcript and protein is completely abolished in the Atrx Δ18Δneo recombinant clones, suggesting that deletion of this region has a highly destabilising effect on the full-length transcript.
T1930 445-453 NNP denotes Northern
T1932 454-457 CC denotes and
T1933 458-465 NNP denotes Western
T1931 466-470 NN denotes blot
T1934 471-479 NNS denotes analyses
T1936 480-481 -LRB- denotes (
T1938 481-487 NN denotes Figure
T1937 488-490 NN denotes 2D
T1939 491-494 CC denotes and
T1940 495-497 NN denotes 2E
T1941 497-498 -RRB- denotes )
T1935 499-507 VBD denotes revealed
T1942 508-512 IN denotes that
T1944 513-516 DT denotes the
T1946 517-521 JJ denotes full
T1948 521-522 HYPH denotes -
T1947 522-528 NN denotes length
T1949 529-533 NN denotes Atrx
T1945 534-544 NN denotes transcript
T1950 545-548 CC denotes and
T1951 549-556 NN denotes protein
T1952 557-559 VBZ denotes is
T1953 560-570 RB denotes completely
T1943 571-580 VBN denotes abolished
T1954 581-583 IN denotes in
T1955 584-587 DT denotes the
T1957 588-600 NN denotes Atrx Δ18Δneo
T1958 601-612 JJ denotes recombinant
T1956 613-619 NNS denotes clones
T1959 619-621 , denotes ,
T1960 621-631 VBG denotes suggesting
T1961 632-636 IN denotes that
T1963 637-645 NN denotes deletion
T1964 646-648 IN denotes of
T1965 649-653 DT denotes this
T1966 654-660 NN denotes region
T1962 661-664 VBZ denotes has
T1967 665-666 DT denotes a
T1969 667-673 RB denotes highly
T1970 674-687 JJ denotes destabilising
T1968 688-694 NN denotes effect
T1971 695-697 IN denotes on
T1972 698-701 DT denotes the
T1974 702-706 JJ denotes full
T1976 706-707 HYPH denotes -
T1975 707-713 NN denotes length
T1973 714-724 NN denotes transcript
T1977 724-725 . denotes .
T1978 725-881 sentence denotes As expected, the truncated Atrxt isoform, the transcript of which is terminated within intron 11 [4], is unaffected by the deletion of exon 18 (Figure 2E).
T1979 726-728 IN denotes As
T1980 729-737 VBN denotes expected
T1982 737-739 , denotes ,
T1983 739-742 DT denotes the
T1985 743-752 VBN denotes truncated
T1986 753-758 NN denotes Atrxt
T1984 759-766 NN denotes isoform
T1987 766-768 , denotes ,
T1988 768-771 DT denotes the
T1989 772-782 NN denotes transcript
T1991 783-785 IN denotes of
T1992 786-791 WDT denotes which
T1993 792-794 VBZ denotes is
T1990 795-805 VBN denotes terminated
T1994 806-812 IN denotes within
T1995 813-819 NN denotes intron
T1996 820-822 CD denotes 11
T1997 823-824 -LRB- denotes [
T1998 824-825 CD denotes 4
T1999 825-826 -RRB- denotes ]
T2000 826-828 , denotes ,
T1981 828-830 VBZ denotes is
T2001 831-841 JJ denotes unaffected
T2002 842-844 IN denotes by
T2003 845-848 DT denotes the
T2004 849-857 NN denotes deletion
T2005 858-860 IN denotes of
T2006 861-865 NN denotes exon
T2007 866-868 CD denotes 18
T2008 869-870 -LRB- denotes (
T2010 870-876 NN denotes Figure
T2009 877-879 NN denotes 2E
T2011 879-880 -RRB- denotes )
T2012 880-881 . denotes .
T2013 881-1085 sentence denotes While the function of Atrxt is not yet clear, this isoform, which contains the PHD-like domain but not the SWI/SNF motifs (Figure 1), is unlikely to be functionally equivalent to the full-length protein.
T2014 882-887 IN denotes While
T2016 888-891 DT denotes the
T2017 892-900 NN denotes function
T2018 901-903 IN denotes of
T2019 904-909 NN denotes Atrxt
T2015 910-912 VBZ denotes is
T2021 913-916 RB denotes not
T2022 917-920 RB denotes yet
T2023 921-926 JJ denotes clear
T2024 926-928 , denotes ,
T2025 928-932 DT denotes this
T2026 933-940 NN denotes isoform
T2027 940-942 , denotes ,
T2028 942-947 WDT denotes which
T2029 948-956 VBZ denotes contains
T2030 957-960 DT denotes the
T2032 961-964 NN denotes PHD
T2034 964-965 HYPH denotes -
T2033 965-969 JJ denotes like
T2031 970-976 NN denotes domain
T2035 977-980 CC denotes but
T2036 981-984 RB denotes not
T2037 985-988 DT denotes the
T2039 989-992 NN denotes SWI
T2041 992-993 HYPH denotes /
T2040 993-996 NN denotes SNF
T2038 997-1003 NNS denotes motifs
T2042 1004-1005 -LRB- denotes (
T2043 1005-1011 NN denotes Figure
T2044 1012-1013 CD denotes 1
T2045 1013-1014 -RRB- denotes )
T2046 1014-1016 , denotes ,
T2020 1016-1018 VBZ denotes is
T2047 1019-1027 JJ denotes unlikely
T2048 1028-1030 TO denotes to
T2049 1031-1033 VB denotes be
T2050 1034-1046 RB denotes functionally
T2051 1047-1057 JJ denotes equivalent
T2052 1058-1060 IN denotes to
T2053 1061-1064 DT denotes the
T2055 1065-1069 JJ denotes full
T2057 1069-1070 HYPH denotes -
T2056 1070-1076 NN denotes length
T2054 1077-1084 NN denotes protein
T2058 1084-1085 . denotes .
T2059 1085-1193 sentence denotes Thus, a conditional knockout strategy allowed the isolation of ES cells that are null for full-length Atrx.
T2060 1086-1090 RB denotes Thus
T2062 1090-1092 , denotes ,
T2063 1092-1093 DT denotes a
T2065 1094-1105 JJ denotes conditional
T2066 1106-1114 NN denotes knockout
T2064 1115-1123 NN denotes strategy
T2061 1124-1131 VBD denotes allowed
T2067 1132-1135 DT denotes the
T2068 1136-1145 NN denotes isolation
T2069 1146-1148 IN denotes of
T2070 1149-1151 NN denotes ES
T2071 1152-1157 NNS denotes cells
T2072 1158-1162 WDT denotes that
T2073 1163-1166 VBP denotes are
T2074 1167-1171 JJ denotes null
T2075 1172-1175 IN denotes for
T2076 1176-1180 JJ denotes full
T2078 1180-1181 HYPH denotes -
T2077 1181-1187 NN denotes length
T2079 1188-1192 NN denotes Atrx
T2080 1192-1193 . denotes .
R1077 T1837 T1838 aux To,generate
R1078 T1838 T1839 advcl generate,transfected
R1079 T1840 T1841 det the,deletion
R1080 T1841 T1838 dobj deletion,generate
R1081 T1842 T1841 amod full,deletion
R1082 T1843 T1838 prep in,generate
R1083 T1844 T1845 compound ES,cells
R1084 T1845 T1843 pobj cells,in
R1085 T1846 T1839 punct ", ",transfected
R1086 T1847 T1848 det the,clones
R1087 T1848 T1839 nsubjpass clones,transfected
R1088 T1849 T1848 compound Atrx flox,clones
R1089 T1850 T1851 punct (,F12
R1090 T1851 T1848 parataxis F12,clones
R1091 T1852 T1851 nummod 1,F12
R1092 T1853 T1851 punct /,F12
R1093 T1854 T1851 cc and,F12
R1094 T1855 T1856 nummod 1,G11
R1095 T1856 T1851 conj G11,F12
R1096 T1857 T1856 punct /,G11
R1097 T1858 T1851 punct ),F12
R1098 T1859 T1839 auxpass were,transfected
R1099 T1860 T1839 advmod transiently,transfected
R1100 T1861 T1839 prep with,transfected
R1101 T1862 T1863 det a,plasmid
R1102 T1863 T1861 pobj plasmid,with
R1103 T1864 T1865 compound Cre,recombinase
R1104 T1865 T1863 compound recombinase,plasmid
R1105 T1866 T1865 punct -,recombinase
R1106 T1867 T1863 compound expression,plasmid
R1107 T1868 T1863 punct (,plasmid
R1108 T1869 T1870 compound pCAGGS,IRESpuro
R1109 T1870 T1863 appos IRESpuro,plasmid
R1110 T1871 T1870 punct -,IRESpuro
R1111 T1872 T1870 compound Cre,IRESpuro
R1112 T1873 T1870 punct -,IRESpuro
R1113 T1874 T1839 punct ),transfected
R1114 T1875 T1839 punct ", ",transfected
R1115 T1876 T1839 cc and,transfected
R1116 T1877 T1878 nsubjpass subclones,bearing
R1117 T1878 T1839 conj bearing,transfected
R1118 T1879 T1878 auxpass were,bearing
R1119 T1880 T1878 aux recovered,bearing
R1120 T1881 T1882 det an,allele
R1121 T1882 T1878 dobj allele,bearing
R1122 T1883 T1884 punct (,Atrx Δ18Δneo
R1123 T1884 T1882 parataxis Atrx Δ18Δneo,allele
R1124 T1885 T1884 prep in,Atrx Δ18Δneo
R1125 T1886 T1887 compound Figure,2A
R1126 T1887 T1885 pobj 2A,in
R1127 T1888 T1884 punct ),Atrx Δ18Δneo
R1128 T1889 T1890 prep in,deleted
R1129 T1890 T1882 relcl deleted,allele
R1130 T1891 T1889 pobj which,in
R1131 T1892 T1893 preconj both,exon
R1132 T1893 T1890 nsubjpass exon,deleted
R1133 T1894 T1893 nummod 18,exon
R1134 T1895 T1893 cc and,exon
R1135 T1896 T1897 det the,cassette
R1136 T1897 T1893 conj cassette,exon
R1137 T1898 T1897 compound neor,cassette
R1138 T1899 T1890 aux had,deleted
R1139 T1900 T1890 auxpass been,deleted
R1140 T1901 T1890 agent by,deleted
R1141 T1902 T1903 det the,recombinase
R1142 T1903 T1901 pobj recombinase,by
R1143 T1904 T1903 compound Cre,recombinase
R1144 T1905 T1906 punct (,resulting
R1145 T1906 T1890 parataxis resulting,deleted
R1146 T1907 T1906 prep from,resulting
R1147 T1908 T1909 det the,event
R1148 T1909 T1907 pobj event,from
R1149 T1910 T1909 compound recombination,event
R1150 T1911 T1909 acl labelled,event
R1151 T1912 T1913 punct “,C
R1152 T1913 T1911 oprd C,labelled
R1153 T1914 T1911 punct ”,labelled
R1154 T1915 T1911 prep in,labelled
R1155 T1916 T1917 det the,allele
R1156 T1917 T1915 pobj allele,in
R1157 T1918 T1917 compound Atrx flox,allele
R1158 T1919 T1917 acl shown,allele
R1159 T1920 T1919 prep in,shown
R1160 T1921 T1922 compound Figure,2A
R1161 T1922 T1920 pobj 2A,in
R1162 T1923 T1906 punct ),resulting
R1163 T1924 T1925 punct (,2C
R1164 T1925 T1890 parataxis 2C,deleted
R1165 T1926 T1925 compound Figure,2C
R1166 T1927 T1925 punct ),2C
R1167 T1928 T1878 punct .,bearing
R1168 T1930 T1931 nmod Northern,blot
R1169 T1931 T1934 compound blot,analyses
R1170 T1932 T1930 cc and,Northern
R1171 T1933 T1930 conj Western,Northern
R1172 T1934 T1935 nsubj analyses,revealed
R1173 T1936 T1937 punct (,2D
R1174 T1937 T1934 parataxis 2D,analyses
R1175 T1938 T1937 compound Figure,2D
R1176 T1939 T1937 cc and,2D
R1177 T1940 T1937 conj 2E,2D
R1178 T1941 T1937 punct ),2D
R1179 T1942 T1943 mark that,abolished
R1180 T1943 T1935 ccomp abolished,revealed
R1181 T1944 T1945 det the,transcript
R1182 T1945 T1943 nsubjpass transcript,abolished
R1183 T1946 T1947 amod full,length
R1184 T1947 T1945 compound length,transcript
R1185 T1948 T1947 punct -,length
R1186 T1949 T1945 compound Atrx,transcript
R1187 T1950 T1945 cc and,transcript
R1188 T1951 T1945 conj protein,transcript
R1189 T1952 T1943 auxpass is,abolished
R1190 T1953 T1943 advmod completely,abolished
R1191 T1954 T1943 prep in,abolished
R1192 T1955 T1956 det the,clones
R1193 T1956 T1954 pobj clones,in
R1194 T1957 T1958 npadvmod Atrx Δ18Δneo,recombinant
R1195 T1958 T1956 amod recombinant,clones
R1196 T1959 T1943 punct ", ",abolished
R1197 T1960 T1943 advcl suggesting,abolished
R1198 T1961 T1962 mark that,has
R1199 T1962 T1960 ccomp has,suggesting
R1200 T1963 T1962 nsubj deletion,has
R1201 T1964 T1963 prep of,deletion
R1202 T1965 T1966 det this,region
R1203 T1966 T1964 pobj region,of
R1204 T1967 T1968 det a,effect
R1205 T1968 T1962 dobj effect,has
R1206 T1969 T1970 advmod highly,destabilising
R1207 T1970 T1968 amod destabilising,effect
R1208 T1971 T1962 prep on,has
R1209 T1972 T1973 det the,transcript
R1210 T1973 T1971 pobj transcript,on
R1211 T1974 T1975 amod full,length
R1212 T1975 T1973 compound length,transcript
R1213 T1976 T1975 punct -,length
R1214 T1977 T1935 punct .,revealed
R1215 T1979 T1980 mark As,expected
R1216 T1980 T1981 advcl expected,is
R1217 T1982 T1981 punct ", ",is
R1218 T1983 T1984 det the,isoform
R1219 T1984 T1981 nsubj isoform,is
R1220 T1985 T1984 amod truncated,isoform
R1221 T1986 T1984 compound Atrxt,isoform
R1222 T1987 T1984 punct ", ",isoform
R1223 T1988 T1989 det the,transcript
R1224 T1989 T1990 dep transcript,terminated
R1225 T1990 T1984 relcl terminated,isoform
R1226 T1991 T1989 prep of,transcript
R1227 T1992 T1991 pobj which,of
R1228 T1993 T1990 auxpass is,terminated
R1229 T1994 T1990 prep within,terminated
R1230 T1995 T1994 pobj intron,within
R1231 T1996 T1995 nummod 11,intron
R1232 T1997 T1998 punct [,4
R1233 T1998 T1990 parataxis 4,terminated
R1234 T1999 T1998 punct ],4
R1235 T2000 T1981 punct ", ",is
R1236 T2001 T1981 acomp unaffected,is
R1237 T2002 T2001 prep by,unaffected
R1238 T2003 T2004 det the,deletion
R1239 T2004 T2002 pobj deletion,by
R1240 T2005 T2004 prep of,deletion
R1241 T2006 T2005 pobj exon,of
R1242 T2007 T2006 nummod 18,exon
R1243 T2008 T2009 punct (,2E
R1244 T2009 T1981 parataxis 2E,is
R1245 T2010 T2009 compound Figure,2E
R1246 T2011 T2009 punct ),2E
R1247 T2012 T1981 punct .,is
R1248 T2014 T2015 mark While,is
R1249 T2015 T2020 advcl is,is
R1250 T2016 T2017 det the,function
R1251 T2017 T2015 nsubj function,is
R1252 T2018 T2017 prep of,function
R1253 T2019 T2018 pobj Atrxt,of
R1254 T2021 T2015 neg not,is
R1255 T2022 T2015 advmod yet,is
R1256 T2023 T2015 acomp clear,is
R1257 T2024 T2020 punct ", ",is
R1258 T2025 T2026 det this,isoform
R1259 T2026 T2020 nsubj isoform,is
R1260 T2027 T2026 punct ", ",isoform
R1261 T2028 T2029 dep which,contains
R1262 T2029 T2026 relcl contains,isoform
R1263 T2030 T2031 det the,domain
R1264 T2031 T2029 dobj domain,contains
R1265 T2032 T2033 npadvmod PHD,like
R1266 T2033 T2031 amod like,domain
R1267 T2034 T2033 punct -,like
R1268 T2035 T2031 cc but,domain
R1269 T2036 T2035 neg not,but
R1270 T2037 T2038 det the,motifs
R1271 T2038 T2031 conj motifs,domain
R1272 T2039 T2040 compound SWI,SNF
R1273 T2040 T2038 compound SNF,motifs
R1274 T2041 T2040 punct /,SNF
R1275 T2042 T2043 punct (,Figure
R1276 T2043 T2029 parataxis Figure,contains
R1277 T2044 T2043 nummod 1,Figure
R1278 T2045 T2043 punct ),Figure
R1279 T2046 T2020 punct ", ",is
R1280 T2047 T2020 acomp unlikely,is
R1281 T2048 T2049 aux to,be
R1282 T2049 T2047 xcomp be,unlikely
R1283 T2050 T2051 advmod functionally,equivalent
R1284 T2051 T2049 acomp equivalent,be
R1285 T2052 T2051 prep to,equivalent
R1286 T2053 T2054 det the,protein
R1287 T2054 T2052 pobj protein,to
R1288 T2055 T2056 amod full,length
R1289 T2056 T2054 compound length,protein
R1290 T2057 T2056 punct -,length
R1291 T2058 T2020 punct .,is
R1292 T2060 T2061 advmod Thus,allowed
R1293 T2062 T2061 punct ", ",allowed
R1294 T2063 T2064 det a,strategy
R1295 T2064 T2061 nsubj strategy,allowed
R1296 T2065 T2066 amod conditional,knockout
R1297 T2066 T2064 compound knockout,strategy
R1298 T2067 T2068 det the,isolation
R1299 T2068 T2061 dobj isolation,allowed
R1300 T2069 T2068 prep of,isolation
R1301 T2070 T2071 compound ES,cells
R1302 T2071 T2069 pobj cells,of
R1303 T2072 T2073 dep that,are
R1304 T2073 T2068 relcl are,isolation
R1305 T2074 T2073 acomp null,are
R1306 T2075 T2074 prep for,null
R1307 T2076 T2077 amod full,length
R1308 T2077 T2079 compound length,Atrx
R1309 T2078 T2077 punct -,length
R1310 T2079 T2075 pobj Atrx,for
R1311 T2080 T2061 punct .,allowed