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PMC:1435744 / 7022-10255 JSONTXT 4 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T5546 0-7 NN denotes Cloning
T5547 8-10 IN denotes of
T5548 11-16 NN denotes mouse
T5550 17-19 NN denotes mr
T5551 19-20 HYPH denotes -
T5549 20-21 NN denotes s
T5552 21-329 sentence denotes In order to identify novel mouse genes preferentially expressed in the developing retina, we screened the National Institute for Biotechnology Information (NCBI) database, UniGene, using Digital Differential Display (DDD) and found EST fragments which are frequently present in mouse retinal cDNA libraries.
T5553 22-24 IN denotes In
T5555 25-30 NN denotes order
T5556 31-33 TO denotes to
T5557 34-42 VB denotes identify
T5558 43-48 JJ denotes novel
T5560 49-54 NN denotes mouse
T5559 55-60 NNS denotes genes
T5561 61-75 RB denotes preferentially
T5562 76-85 VBN denotes expressed
T5563 86-88 IN denotes in
T5564 89-92 DT denotes the
T5566 93-103 VBG denotes developing
T5565 104-110 NN denotes retina
T5567 110-112 , denotes ,
T5568 112-114 PRP denotes we
T5554 115-123 VBD denotes screened
T5569 124-127 DT denotes the
T5571 128-136 NNP denotes National
T5572 137-146 NNP denotes Institute
T5573 147-150 IN denotes for
T5574 151-164 NNP denotes Biotechnology
T5575 165-176 NNP denotes Information
T5576 177-178 -LRB- denotes (
T5577 178-182 NNP denotes NCBI
T5578 182-183 -RRB- denotes )
T5570 184-192 NN denotes database
T5579 192-194 , denotes ,
T5580 194-201 NNP denotes UniGene
T5581 201-203 , denotes ,
T5582 203-208 VBG denotes using
T5583 209-216 NNP denotes Digital
T5585 217-229 NNP denotes Differential
T5584 230-237 NNP denotes Display
T5586 238-239 -LRB- denotes (
T5587 239-242 NNP denotes DDD
T5588 242-243 -RRB- denotes )
T5589 244-247 CC denotes and
T5590 248-253 VBD denotes found
T5591 254-257 NN denotes EST
T5592 258-267 NNS denotes fragments
T5593 268-273 WDT denotes which
T5594 274-277 VBP denotes are
T5595 278-288 RB denotes frequently
T5596 289-296 JJ denotes present
T5597 297-299 IN denotes in
T5598 300-305 NN denotes mouse
T5600 306-313 JJ denotes retinal
T5601 314-318 NN denotes cDNA
T5599 319-328 NNS denotes libraries
T5602 328-329 . denotes .
T5603 329-451 sentence denotes We found that one clone in these cDNAs encodes a protein containing a SAM domain related to that of polyhomeotic protein.
T5604 330-332 PRP denotes We
T5605 333-338 VBD denotes found
T5606 339-343 IN denotes that
T5608 344-347 CD denotes one
T5609 348-353 NN denotes clone
T5610 354-356 IN denotes in
T5611 357-362 DT denotes these
T5612 363-368 NNS denotes cDNAs
T5607 369-376 VBZ denotes encodes
T5613 377-378 DT denotes a
T5614 379-386 NN denotes protein
T5615 387-397 VBG denotes containing
T5616 398-399 DT denotes a
T5618 400-403 NN denotes SAM
T5617 404-410 NN denotes domain
T5619 411-418 VBN denotes related
T5620 419-421 IN denotes to
T5621 422-426 DT denotes that
T5622 427-429 IN denotes of
T5623 430-442 JJ denotes polyhomeotic
T5624 443-450 NN denotes protein
T5625 450-451 . denotes .
T5626 451-590 sentence denotes A PCR fragment corresponding to this mouse clone was used to screen a mouse P0-P3 retinal cDNA library to obtain a full-length cDNA clone.
T5627 452-453 DT denotes A
T5629 454-457 NN denotes PCR
T5628 458-466 NN denotes fragment
T5631 467-480 VBG denotes corresponding
T5632 481-483 IN denotes to
T5633 484-488 DT denotes this
T5635 489-494 NN denotes mouse
T5634 495-500 NN denotes clone
T5636 501-504 VBD denotes was
T5630 505-509 VBN denotes used
T5637 510-512 TO denotes to
T5638 513-519 VB denotes screen
T5639 520-521 DT denotes a
T5641 522-527 NN denotes mouse
T5642 528-530 NN denotes P0
T5644 530-531 SYM denotes -
T5643 531-533 NN denotes P3
T5645 534-541 JJ denotes retinal
T5646 542-546 NN denotes cDNA
T5640 547-554 NN denotes library
T5647 555-557 TO denotes to
T5648 558-564 VB denotes obtain
T5649 565-566 DT denotes a
T5651 567-571 JJ denotes full
T5653 571-572 HYPH denotes -
T5652 572-578 NN denotes length
T5654 579-583 NN denotes cDNA
T5650 584-589 NN denotes clone
T5655 589-590 . denotes .
T5656 590-689 sentence denotes Sequence analysis showed that this cDNA was a novel gene encoding a SAM domain-containing protein.
T5657 591-599 NN denotes Sequence
T5658 600-608 NN denotes analysis
T5659 609-615 VBD denotes showed
T5660 616-620 IN denotes that
T5662 621-625 DT denotes this
T5663 626-630 NN denotes cDNA
T5661 631-634 VBD denotes was
T5664 635-636 DT denotes a
T5666 637-642 JJ denotes novel
T5665 643-647 NN denotes gene
T5667 648-656 VBG denotes encoding
T5668 657-658 DT denotes a
T5670 659-662 NN denotes SAM
T5671 663-669 NN denotes domain
T5673 669-670 HYPH denotes -
T5672 670-680 VBG denotes containing
T5669 681-688 NN denotes protein
T5674 688-689 . denotes .
T5675 689-761 sentence denotes We referred to this protein as mr-s (major retinal SAM domain protein).
T5676 690-692 PRP denotes We
T5677 693-701 VBD denotes referred
T5678 702-704 IN denotes to
T5679 705-709 DT denotes this
T5680 710-717 NN denotes protein
T5681 718-720 IN denotes as
T5682 721-723 NN denotes mr
T5684 723-724 HYPH denotes -
T5683 724-725 NN denotes s
T5685 726-727 -LRB- denotes (
T5686 727-732 JJ denotes major
T5688 733-740 JJ denotes retinal
T5689 741-744 NN denotes SAM
T5690 745-751 NN denotes domain
T5687 752-759 NN denotes protein
T5691 759-760 -RRB- denotes )
T5692 760-761 . denotes .
T5693 761-874 sentence denotes As shown in Fig. 1A, a translation initiation codon is present in the same open reading frame as the SAM domain.
T5694 762-764 IN denotes As
T5695 765-770 VBN denotes shown
T5697 771-773 IN denotes in
T5698 774-778 NN denotes Fig.
T5699 779-781 NN denotes 1A
T5700 781-783 , denotes ,
T5701 783-784 DT denotes a
T5703 785-796 NN denotes translation
T5704 797-807 NN denotes initiation
T5702 808-813 NN denotes codon
T5696 814-816 VBZ denotes is
T5705 817-824 JJ denotes present
T5706 825-827 IN denotes in
T5707 828-831 DT denotes the
T5709 832-836 JJ denotes same
T5710 837-841 JJ denotes open
T5711 842-849 NN denotes reading
T5708 850-855 NN denotes frame
T5712 856-858 IN denotes as
T5713 859-862 DT denotes the
T5715 863-866 NN denotes SAM
T5714 867-873 NN denotes domain
T5716 873-874 . denotes .
T5717 874-1031 sentence denotes This initiation site shows similarity to the consensus sequence proposed by Kozak [32] including the presence of the highly conserved purine at position -3.
T5718 875-879 DT denotes This
T5720 880-890 NN denotes initiation
T5719 891-895 NN denotes site
T5721 896-901 VBZ denotes shows
T5722 902-912 NN denotes similarity
T5723 913-915 IN denotes to
T5724 916-919 DT denotes the
T5726 920-929 NN denotes consensus
T5725 930-938 NN denotes sequence
T5727 939-947 VBN denotes proposed
T5728 948-950 IN denotes by
T5729 951-956 NN denotes Kozak
T5730 957-958 -LRB- denotes [
T5731 958-960 CD denotes 32
T5732 960-961 -RRB- denotes ]
T5733 962-971 VBG denotes including
T5734 972-975 DT denotes the
T5735 976-984 NN denotes presence
T5736 985-987 IN denotes of
T5737 988-991 DT denotes the
T5739 992-998 RB denotes highly
T5740 999-1008 VBN denotes conserved
T5738 1009-1015 NN denotes purine
T5741 1016-1018 IN denotes at
T5742 1019-1027 NN denotes position
T5743 1028-1029 SYM denotes -
T5744 1029-1030 CD denotes 3
T5745 1030-1031 . denotes .
T5746 1031-1106 sentence denotes The stop codon of the predicted mr-s protein is also indicated in Fig. 1A.
T5747 1032-1035 DT denotes The
T5749 1036-1040 NN denotes stop
T5748 1041-1046 NN denotes codon
T5751 1047-1049 IN denotes of
T5752 1050-1053 DT denotes the
T5754 1054-1063 VBN denotes predicted
T5755 1064-1066 NN denotes mr
T5757 1066-1067 HYPH denotes -
T5756 1067-1068 NN denotes s
T5753 1069-1076 NN denotes protein
T5758 1077-1079 VBZ denotes is
T5759 1080-1084 RB denotes also
T5750 1085-1094 VBN denotes indicated
T5760 1095-1097 IN denotes in
T5761 1098-1102 NN denotes Fig.
T5762 1103-1105 NN denotes 1A
T5763 1105-1106 . denotes .
T5764 1106-1273 sentence denotes The amino acid sequence of the SAM domain of mr-s protein (Fig. 1A, boxed sequence) exhibits homology with SAM domains of EphB2, EphA4, MPH1, TEL and Smaug (Fig. 1B).
T5765 1107-1110 DT denotes The
T5767 1111-1116 NN denotes amino
T5768 1117-1121 NN denotes acid
T5766 1122-1130 NN denotes sequence
T5770 1131-1133 IN denotes of
T5771 1134-1137 DT denotes the
T5773 1138-1141 NN denotes SAM
T5772 1142-1148 NN denotes domain
T5774 1149-1151 IN denotes of
T5775 1152-1154 NN denotes mr
T5777 1154-1155 HYPH denotes -
T5776 1155-1156 NN denotes s
T5778 1157-1164 NN denotes protein
T5779 1165-1166 -LRB- denotes (
T5781 1166-1170 NN denotes Fig.
T5780 1171-1173 NN denotes 1A
T5782 1173-1175 , denotes ,
T5783 1175-1180 VBN denotes boxed
T5784 1181-1189 NN denotes sequence
T5785 1189-1190 -RRB- denotes )
T5769 1191-1199 VBZ denotes exhibits
T5786 1200-1208 NN denotes homology
T5787 1209-1213 IN denotes with
T5788 1214-1217 NN denotes SAM
T5789 1218-1225 NNS denotes domains
T5790 1226-1228 IN denotes of
T5791 1229-1234 NN denotes EphB2
T5792 1234-1236 , denotes ,
T5793 1236-1241 NN denotes EphA4
T5794 1241-1243 , denotes ,
T5795 1243-1247 NN denotes MPH1
T5796 1247-1249 , denotes ,
T5797 1249-1252 NN denotes TEL
T5798 1253-1256 CC denotes and
T5799 1257-1262 NN denotes Smaug
T5800 1263-1264 -LRB- denotes (
T5802 1264-1268 NN denotes Fig.
T5801 1269-1271 NN denotes 1B
T5803 1271-1272 -RRB- denotes )
T5804 1272-1273 . denotes .
T5805 1273-1402 sentence denotes By phylogenetic analysis, the SAM domain of mr-s is most closely related to that of Mph1/Rae28, a mouse homolog of ph (Fig. 1C).
T5806 1274-1276 IN denotes By
T5808 1277-1289 JJ denotes phylogenetic
T5809 1290-1298 NN denotes analysis
T5810 1298-1300 , denotes ,
T5811 1300-1303 DT denotes the
T5813 1304-1307 NN denotes SAM
T5812 1308-1314 NN denotes domain
T5814 1315-1317 IN denotes of
T5815 1318-1320 NN denotes mr
T5817 1320-1321 HYPH denotes -
T5816 1321-1322 NN denotes s
T5818 1323-1325 VBZ denotes is
T5819 1326-1330 RBS denotes most
T5820 1331-1338 RB denotes closely
T5807 1339-1346 VBN denotes related
T5821 1347-1349 IN denotes to
T5822 1350-1354 DT denotes that
T5823 1355-1357 IN denotes of
T5824 1358-1362 NN denotes Mph1
T5826 1362-1363 HYPH denotes /
T5825 1363-1368 NN denotes Rae28
T5827 1368-1370 , denotes ,
T5828 1370-1371 DT denotes a
T5830 1372-1377 NN denotes mouse
T5829 1378-1385 NN denotes homolog
T5831 1386-1388 IN denotes of
T5832 1389-1391 NN denotes ph
T5833 1392-1393 -LRB- denotes (
T5835 1393-1397 NN denotes Fig.
T5834 1398-1400 NN denotes 1C
T5836 1400-1401 -RRB- denotes )
T5837 1401-1402 . denotes .
T5838 1402-1556 sentence denotes Mouse mr-s protein is conserved in rat, human, chick and zebrafish, which display 91%, 70%, 36% and 26% identity with mouse mr-s, respectively (Fig. 1D).
T5839 1403-1408 NN denotes Mouse
T5841 1409-1411 NN denotes mr
T5843 1411-1412 HYPH denotes -
T5842 1412-1413 NN denotes s
T5840 1414-1421 NN denotes protein
T5845 1422-1424 VBZ denotes is
T5844 1425-1434 VBN denotes conserved
T5846 1435-1437 IN denotes in
T5847 1438-1441 NN denotes rat
T5848 1441-1443 , denotes ,
T5849 1443-1448 JJ denotes human
T5850 1448-1450 , denotes ,
T5851 1450-1455 NN denotes chick
T5852 1456-1459 CC denotes and
T5853 1460-1469 NN denotes zebrafish
T5854 1469-1471 , denotes ,
T5855 1471-1476 WDT denotes which
T5856 1477-1484 VBP denotes display
T5857 1485-1487 CD denotes 91
T5858 1487-1488 NN denotes %
T5860 1488-1490 , denotes ,
T5861 1490-1492 CD denotes 70
T5862 1492-1493 NN denotes %
T5863 1493-1495 , denotes ,
T5864 1495-1497 CD denotes 36
T5865 1497-1498 NN denotes %
T5866 1499-1502 CC denotes and
T5867 1503-1505 CD denotes 26
T5868 1505-1506 NN denotes %
T5859 1507-1515 NN denotes identity
T5869 1516-1520 IN denotes with
T5870 1521-1526 NN denotes mouse
T5872 1527-1529 NN denotes mr
T5873 1529-1530 HYPH denotes -
T5871 1530-1531 NN denotes s
T5874 1531-1533 , denotes ,
T5875 1533-1545 RB denotes respectively
T5876 1546-1547 -LRB- denotes (
T5878 1547-1551 NN denotes Fig.
T5877 1552-1554 NN denotes 1D
T5879 1554-1555 -RRB- denotes )
T5880 1555-1556 . denotes .
T5881 1556-1727 sentence denotes The SAM domains of rat, human, chick and zebrafish mr-s protein are highly conserved and display 96%, 90%, 76% and 72% identity with the SAM domain of mouse mr-s protein.
T5882 1557-1560 DT denotes The
T5884 1561-1564 NN denotes SAM
T5883 1565-1572 NNS denotes domains
T5886 1573-1575 IN denotes of
T5887 1576-1579 NN denotes rat
T5889 1579-1581 , denotes ,
T5890 1581-1586 JJ denotes human
T5891 1586-1588 , denotes ,
T5892 1588-1593 NN denotes chick
T5893 1594-1597 CC denotes and
T5894 1598-1607 NN denotes zebrafish
T5895 1608-1610 NN denotes mr
T5897 1610-1611 HYPH denotes -
T5896 1611-1612 NN denotes s
T5888 1613-1620 NN denotes protein
T5898 1621-1624 VBP denotes are
T5899 1625-1631 RB denotes highly
T5885 1632-1641 VBN denotes conserved
T5900 1642-1645 CC denotes and
T5901 1646-1653 VBP denotes display
T5902 1654-1656 CD denotes 96
T5903 1656-1657 NN denotes %
T5905 1657-1659 , denotes ,
T5906 1659-1661 CD denotes 90
T5907 1661-1662 NN denotes %
T5908 1662-1664 , denotes ,
T5909 1664-1666 CD denotes 76
T5910 1666-1667 NN denotes %
T5911 1668-1671 CC denotes and
T5912 1672-1674 CD denotes 72
T5913 1674-1675 NN denotes %
T5904 1676-1684 NN denotes identity
T5914 1685-1689 IN denotes with
T5915 1690-1693 DT denotes the
T5917 1694-1697 NN denotes SAM
T5916 1698-1704 NN denotes domain
T5918 1705-1707 IN denotes of
T5919 1708-1713 NN denotes mouse
T5921 1714-1716 NN denotes mr
T5923 1716-1717 HYPH denotes -
T5922 1717-1718 NN denotes s
T5920 1719-1726 NN denotes protein
T5924 1726-1727 . denotes .
T5925 1727-1875 sentence denotes The chromosomal localizations of mouse and human mr-s genes were determined by searching the mouse and human genome databases (NCBI), respectively.
T5926 1728-1731 DT denotes The
T5928 1732-1743 JJ denotes chromosomal
T5927 1744-1757 NNS denotes localizations
T5930 1758-1760 IN denotes of
T5931 1761-1766 NN denotes mouse
T5933 1767-1770 CC denotes and
T5934 1771-1776 JJ denotes human
T5935 1777-1779 NN denotes mr
T5937 1779-1780 HYPH denotes -
T5936 1780-1781 NN denotes s
T5932 1782-1787 NNS denotes genes
T5938 1788-1792 VBD denotes were
T5929 1793-1803 VBN denotes determined
T5939 1804-1806 IN denotes by
T5940 1807-1816 VBG denotes searching
T5941 1817-1820 DT denotes the
T5943 1821-1826 NN denotes mouse
T5944 1827-1830 CC denotes and
T5945 1831-1836 JJ denotes human
T5946 1837-1843 NN denotes genome
T5942 1844-1853 NNS denotes databases
T5947 1854-1855 -LRB- denotes (
T5948 1855-1859 NN denotes NCBI
T5949 1859-1860 -RRB- denotes )
T5950 1860-1862 , denotes ,
T5951 1862-1874 RB denotes respectively
T5952 1874-1875 . denotes .
T5953 1875-1963 sentence denotes Mouse mr-s is mapped to chromosome 4E2, and human MR-S is mapped to chromosome 1p36.33.
T5954 1876-1881 NN denotes Mouse
T5956 1882-1884 NN denotes mr
T5957 1884-1885 HYPH denotes -
T5955 1885-1886 NN denotes s
T5959 1887-1889 VBZ denotes is
T5958 1890-1896 VBN denotes mapped
T5960 1897-1899 IN denotes to
T5961 1900-1910 NN denotes chromosome
T5962 1911-1914 NN denotes 4E2
T5963 1914-1916 , denotes ,
T5964 1916-1919 CC denotes and
T5965 1920-1925 JJ denotes human
T5967 1926-1928 NN denotes MR
T5968 1928-1929 HYPH denotes -
T5966 1929-1930 NN denotes S
T5970 1931-1933 VBZ denotes is
T5969 1934-1940 VBN denotes mapped
T5971 1941-1943 IN denotes to
T5972 1944-1954 NN denotes chromosome
T5973 1955-1962 NN denotes 1p36.33
T5974 1962-1963 . denotes .
T5975 1963-2026 sentence denotes LCA is the most common cause of inherited childhood blindness.
T5976 1964-1967 NN denotes LCA
T5977 1968-1970 VBZ denotes is
T5978 1971-1974 DT denotes the
T5980 1975-1979 RBS denotes most
T5981 1980-1986 JJ denotes common
T5979 1987-1992 NN denotes cause
T5982 1993-1995 IN denotes of
T5983 1996-2005 VBN denotes inherited
T5985 2006-2015 NN denotes childhood
T5984 2016-2025 NN denotes blindness
T5986 2025-2026 . denotes .
T5987 2026-2127 sentence denotes Human MR-S maps in the vicinity region of the LCA9, recently identified as a new locus for LCA [33].
T5988 2027-2032 JJ denotes Human
T5990 2033-2035 NN denotes MR
T5991 2035-2036 HYPH denotes -
T5989 2036-2037 NN denotes S
T5992 2038-2042 VBZ denotes maps
T5993 2043-2045 IN denotes in
T5994 2046-2049 DT denotes the
T5996 2050-2058 NN denotes vicinity
T5995 2059-2065 NN denotes region
T5997 2066-2068 IN denotes of
T5998 2069-2072 DT denotes the
T5999 2073-2077 NN denotes LCA9
T6000 2077-2079 , denotes ,
T6001 2079-2087 RB denotes recently
T6002 2088-2098 VBN denotes identified
T6003 2099-2101 IN denotes as
T6004 2102-2103 DT denotes a
T6006 2104-2107 JJ denotes new
T6005 2108-2113 NN denotes locus
T6007 2114-2117 IN denotes for
T6008 2118-2121 NN denotes LCA
T6009 2122-2123 -LRB- denotes [
T6010 2123-2125 CD denotes 33
T6011 2125-2126 -RRB- denotes ]
T6012 2126-2127 . denotes .
T28701 2138-2140 NN denotes mr
T28703 2140-2141 HYPH denotes -
T28702 2141-2142 NN denotes s
T28704 2143-2153 NN denotes nucleotide
T28706 2154-2157 CC denotes and
T28707 2158-2163 NN denotes amino
T28708 2164-2168 NN denotes acid
T28705 2169-2178 NNS denotes sequences
T28709 2178-2179 . denotes .
T28710 2179-2226 sentence denotes (A) mr-s nucleotide and amino acids sequences.
T28711 2180-2181 -LRB- denotes (
T28712 2181-2182 LS denotes A
T28714 2182-2183 -RRB- denotes )
T28715 2184-2186 NN denotes mr
T28717 2186-2187 HYPH denotes -
T28716 2187-2188 NN denotes s
T28718 2189-2199 NN denotes nucleotide
T28719 2200-2203 CC denotes and
T28720 2204-2209 NN denotes amino
T28721 2210-2215 NNS denotes acids
T28713 2216-2225 NNS denotes sequences
T28722 2225-2226 . denotes .
T28723 2226-2341 sentence denotes Boxed amino acids are the SAM domain sequence and the dashed box indicates a putative nuclear localization signal.
T28724 2227-2232 VBN denotes Boxed
T28726 2233-2238 NN denotes amino
T28725 2239-2244 NNS denotes acids
T28727 2245-2248 VBP denotes are
T28728 2249-2252 DT denotes the
T28730 2253-2256 NN denotes SAM
T28731 2257-2263 NN denotes domain
T28729 2264-2272 NN denotes sequence
T28732 2273-2276 CC denotes and
T28733 2277-2280 DT denotes the
T28735 2281-2287 JJ denotes dashed
T28734 2288-2291 NN denotes box
T28736 2292-2301 VBZ denotes indicates
T28737 2302-2303 DT denotes a
T28739 2304-2312 JJ denotes putative
T28740 2313-2320 JJ denotes nuclear
T28741 2321-2333 NN denotes localization
T28738 2334-2340 NN denotes signal
T28742 2340-2341 . denotes .
T28743 2341-2412 sentence denotes The underline indicates a putative polyadenylation termination signal.
T28744 2342-2345 DT denotes The
T28745 2346-2355 NN denotes underline
T28746 2356-2365 VBZ denotes indicates
T28747 2366-2367 DT denotes a
T28749 2368-2376 JJ denotes putative
T28750 2377-2392 NN denotes polyadenylation
T28751 2393-2404 NN denotes termination
T28748 2405-2411 NN denotes signal
T28752 2411-2412 . denotes .
T28753 2412-2486 sentence denotes (B) Alignment of SAM domain sequences for SAM domain-containing proteins.
T28754 2413-2414 -LRB- denotes (
T28755 2414-2415 LS denotes B
T28757 2415-2416 -RRB- denotes )
T28756 2417-2426 NN denotes Alignment
T28758 2427-2429 IN denotes of
T28759 2430-2433 NN denotes SAM
T28760 2434-2440 NN denotes domain
T28761 2441-2450 NNS denotes sequences
T28762 2451-2454 IN denotes for
T28763 2455-2458 NN denotes SAM
T28764 2459-2465 NN denotes domain
T28766 2465-2466 HYPH denotes -
T28765 2466-2476 VBG denotes containing
T28767 2477-2485 NN denotes proteins
T28768 2485-2486 . denotes .
T28769 2486-2527 sentence denotes The five alpha helices are marked H1-H5.
T28770 2487-2490 DT denotes The
T28772 2491-2495 CD denotes five
T28773 2496-2501 NN denotes alpha
T28771 2502-2509 NNS denotes helices
T28775 2510-2513 VBP denotes are
T28774 2514-2520 VBN denotes marked
T28776 2521-2523 NN denotes H1
T28777 2523-2524 SYM denotes -
T28778 2524-2526 NN denotes H5
T28779 2526-2527 . denotes .
T28780 2527-2651 sentence denotes Conserved amino acid residues are shown with a dark shadow and functionally similar residues are shown with a light shadow.
T28781 2528-2537 VBN denotes Conserved
T28783 2538-2543 NN denotes amino
T28784 2544-2548 NN denotes acid
T28782 2549-2557 NNS denotes residues
T28786 2558-2561 VBP denotes are
T28785 2562-2567 VBN denotes shown
T28787 2568-2572 IN denotes with
T28788 2573-2574 DT denotes a
T28790 2575-2579 JJ denotes dark
T28789 2580-2586 NN denotes shadow
T28791 2587-2590 CC denotes and
T28792 2591-2603 RB denotes functionally
T28793 2604-2611 JJ denotes similar
T28794 2612-2620 NNS denotes residues
T28796 2621-2624 VBP denotes are
T28795 2625-2630 VBN denotes shown
T28797 2631-2635 IN denotes with
T28798 2636-2637 DT denotes a
T28800 2638-2643 JJ denotes light
T28799 2644-2650 NN denotes shadow
T28801 2650-2651 . denotes .
T28802 2651-2721 sentence denotes The sites that were targeted for mutagenesis are indicated by arrows.
T28803 2652-2655 DT denotes The
T28804 2656-2661 NNS denotes sites
T28806 2662-2666 WDT denotes that
T28808 2667-2671 VBD denotes were
T28807 2672-2680 VBN denotes targeted
T28809 2681-2684 IN denotes for
T28810 2685-2696 NN denotes mutagenesis
T28811 2697-2700 VBP denotes are
T28805 2701-2710 VBN denotes indicated
T28812 2711-2713 IN denotes by
T28813 2714-2720 NNS denotes arrows
T28814 2720-2721 . denotes .
T28815 2721-2778 sentence denotes (C) Phylogenetic tree of SAM domain-containing proteins.
T28816 2722-2723 -LRB- denotes (
T28817 2723-2724 LS denotes C
T28819 2724-2725 -RRB- denotes )
T28820 2726-2738 JJ denotes Phylogenetic
T28818 2739-2743 NN denotes tree
T28821 2744-2746 IN denotes of
T28822 2747-2750 NN denotes SAM
T28823 2751-2757 NN denotes domain
T28825 2757-2758 HYPH denotes -
T28824 2758-2768 VBG denotes containing
T28826 2769-2777 NN denotes proteins
T28827 2777-2778 . denotes .
T28828 2778-2862 sentence denotes Amino acid sequences were analyzed by the neighbor-joining method in MacVector 7.2.
T28829 2779-2784 NN denotes Amino
T28830 2785-2789 NN denotes acid
T28831 2790-2799 NNS denotes sequences
T28833 2800-2804 VBD denotes were
T28832 2805-2813 VBN denotes analyzed
T28834 2814-2816 IN denotes by
T28835 2817-2820 DT denotes the
T28837 2821-2829 NN denotes neighbor
T28839 2829-2830 HYPH denotes -
T28838 2830-2837 VBG denotes joining
T28836 2838-2844 NN denotes method
T28840 2845-2847 IN denotes in
T28841 2848-2857 NNP denotes MacVector
T28842 2858-2861 CD denotes 7.2
T28843 2861-2862 . denotes .
T28844 2862-2928 sentence denotes Branch lengths reflect the mean number of substitutions per site.
T28845 2863-2869 NN denotes Branch
T28846 2870-2877 NNS denotes lengths
T28847 2878-2885 VBP denotes reflect
T28848 2886-2889 DT denotes the
T28850 2890-2894 NN denotes mean
T28849 2895-2901 NN denotes number
T28851 2902-2904 IN denotes of
T28852 2905-2918 NNS denotes substitutions
T28853 2919-2922 IN denotes per
T28854 2923-2927 NN denotes site
T28855 2927-2928 . denotes .
T28856 2928-3039 sentence denotes (D) Schematic comparison of the amino acid sequences for mouse, rat, human, chick and zebrafish mr-s proteins.
T28857 2929-2930 -LRB- denotes (
T28858 2930-2931 LS denotes D
T28860 2931-2932 -RRB- denotes )
T28861 2933-2942 JJ denotes Schematic
T28859 2943-2953 NN denotes comparison
T28862 2954-2956 IN denotes of
T28863 2957-2960 DT denotes the
T28865 2961-2966 NN denotes amino
T28866 2967-2971 NN denotes acid
T28864 2972-2981 NNS denotes sequences
T28867 2982-2985 IN denotes for
T28868 2986-2991 NN denotes mouse
T28870 2991-2993 , denotes ,
T28871 2993-2996 NN denotes rat
T28872 2996-2998 , denotes ,
T28873 2998-3003 JJ denotes human
T28874 3003-3005 , denotes ,
T28875 3005-3010 NN denotes chick
T28876 3011-3014 CC denotes and
T28877 3015-3024 NN denotes zebrafish
T28878 3025-3027 NN denotes mr
T28880 3027-3028 HYPH denotes -
T28879 3028-3029 NN denotes s
T28869 3030-3038 NN denotes proteins
T28881 3038-3039 . denotes .
T28882 3039-3159 sentence denotes The percent similarity of the SAM domains and other regions to the corresponding regions of the mouse protein is shown.
T28883 3040-3043 DT denotes The
T28885 3044-3051 NN denotes percent
T28884 3052-3062 NN denotes similarity
T28887 3063-3065 IN denotes of
T28888 3066-3069 DT denotes the
T28890 3070-3073 NN denotes SAM
T28889 3074-3081 NNS denotes domains
T28891 3082-3085 CC denotes and
T28892 3086-3091 JJ denotes other
T28893 3092-3099 NNS denotes regions
T28894 3100-3102 IN denotes to
T28895 3103-3106 DT denotes the
T28897 3107-3120 VBG denotes corresponding
T28896 3121-3128 NNS denotes regions
T28898 3129-3131 IN denotes of
T28899 3132-3135 DT denotes the
T28901 3136-3141 NN denotes mouse
T28900 3142-3149 NN denotes protein
T28902 3150-3152 VBZ denotes is
T28886 3153-3158 VBN denotes shown
T28903 3158-3159 . denotes .
T28904 3159-3233 sentence denotes Overall sequence similarity with the mouse protein is shown on the right.
T28905 3160-3167 JJ denotes Overall
T28907 3168-3176 NN denotes sequence
T28906 3177-3187 NN denotes similarity
T28909 3188-3192 IN denotes with
T28910 3193-3196 DT denotes the
T28912 3197-3202 NN denotes mouse
T28911 3203-3210 NN denotes protein
T28913 3211-3213 VBZ denotes is
T28908 3214-3219 VBN denotes shown
T28914 3220-3222 IN denotes on
T28915 3223-3226 DT denotes the
T28916 3227-3232 NN denotes right
T28917 3232-3233 . denotes .
R1266 T5547 T5546 prep of,Cloning
R1267 T5548 T5549 compound mouse,s
R1268 T5549 T5547 pobj s,of
R1269 T5550 T5549 compound mr,s
R1270 T5551 T5549 punct -,s
R1271 T5553 T5554 prep In,screened
R1272 T5555 T5553 pobj order,In
R1273 T5556 T5557 aux to,identify
R1274 T5557 T5555 acl identify,order
R1275 T5558 T5559 amod novel,genes
R1276 T5559 T5557 dobj genes,identify
R1277 T5560 T5559 compound mouse,genes
R1278 T5561 T5562 advmod preferentially,expressed
R1279 T5562 T5559 acl expressed,genes
R1280 T5563 T5562 prep in,expressed
R1281 T5564 T5565 det the,retina
R1282 T5565 T5563 pobj retina,in
R1283 T5566 T5565 amod developing,retina
R1284 T5567 T5554 punct ", ",screened
R1285 T5568 T5554 nsubj we,screened
R1286 T5569 T5570 det the,database
R1287 T5570 T5554 dobj database,screened
R1288 T5571 T5572 nmod National,Institute
R1289 T5572 T5570 nmod Institute,database
R1290 T5573 T5572 prep for,Institute
R1291 T5574 T5575 compound Biotechnology,Information
R1292 T5575 T5573 pobj Information,for
R1293 T5576 T5572 punct (,Institute
R1294 T5577 T5572 appos NCBI,Institute
R1295 T5578 T5570 punct ),database
R1296 T5579 T5570 punct ", ",database
R1297 T5580 T5570 appos UniGene,database
R1298 T5581 T5554 punct ", ",screened
R1299 T5582 T5554 advcl using,screened
R1300 T5583 T5584 compound Digital,Display
R1301 T5584 T5582 dobj Display,using
R1302 T5585 T5584 compound Differential,Display
R1303 T5586 T5584 punct (,Display
R1304 T5587 T5584 appos DDD,Display
R1305 T5588 T5554 punct ),screened
R1306 T5589 T5554 cc and,screened
R1307 T5590 T5554 conj found,screened
R1308 T5591 T5592 compound EST,fragments
R1309 T5592 T5590 dobj fragments,found
R1310 T5593 T5594 dep which,are
R1311 T5594 T5592 relcl are,fragments
R1312 T5595 T5594 advmod frequently,are
R1313 T5596 T5594 acomp present,are
R1314 T5597 T5594 prep in,are
R1315 T5598 T5599 nmod mouse,libraries
R1316 T5599 T5597 pobj libraries,in
R1317 T5600 T5599 amod retinal,libraries
R1318 T5601 T5599 compound cDNA,libraries
R1319 T5602 T5554 punct .,screened
R1320 T5604 T5605 nsubj We,found
R1321 T5606 T5607 mark that,encodes
R1322 T5607 T5605 ccomp encodes,found
R1323 T5608 T5609 nummod one,clone
R1324 T5609 T5607 nsubj clone,encodes
R1325 T5610 T5609 prep in,clone
R1326 T5611 T5612 det these,cDNAs
R1327 T5612 T5610 pobj cDNAs,in
R1328 T5613 T5614 det a,protein
R1329 T5614 T5607 dobj protein,encodes
R1330 T5615 T5614 acl containing,protein
R1331 T5616 T5617 det a,domain
R1332 T5617 T5615 dobj domain,containing
R1333 T5618 T5617 compound SAM,domain
R1334 T5619 T5617 acl related,domain
R1335 T5620 T5619 prep to,related
R1336 T5621 T5620 pobj that,to
R1337 T5622 T5621 prep of,that
R1338 T5623 T5624 amod polyhomeotic,protein
R1339 T5624 T5622 pobj protein,of
R1340 T5625 T5605 punct .,found
R1341 T5627 T5628 det A,fragment
R1342 T5628 T5630 nsubjpass fragment,used
R1343 T5629 T5628 compound PCR,fragment
R1344 T5631 T5628 acl corresponding,fragment
R1345 T5632 T5631 prep to,corresponding
R1346 T5633 T5634 det this,clone
R1347 T5634 T5632 pobj clone,to
R1348 T5635 T5634 compound mouse,clone
R1349 T5636 T5630 auxpass was,used
R1350 T5637 T5638 aux to,screen
R1351 T5638 T5630 advcl screen,used
R1352 T5639 T5640 det a,library
R1353 T5640 T5638 dobj library,screen
R1354 T5641 T5640 nmod mouse,library
R1355 T5642 T5643 nmod P0,P3
R1356 T5643 T5640 nmod P3,library
R1357 T5644 T5643 punct -,P3
R1358 T5645 T5640 amod retinal,library
R1359 T5646 T5640 compound cDNA,library
R1360 T5647 T5648 aux to,obtain
R1361 T5648 T5638 advcl obtain,screen
R1362 T5649 T5650 det a,clone
R1363 T5650 T5648 dobj clone,obtain
R1364 T5651 T5652 amod full,length
R1365 T5652 T5650 compound length,clone
R1366 T5653 T5652 punct -,length
R1367 T5654 T5650 compound cDNA,clone
R1368 T5655 T5630 punct .,used
R1369 T5657 T5658 compound Sequence,analysis
R1370 T5658 T5659 nsubj analysis,showed
R1371 T5660 T5661 mark that,was
R1372 T5661 T5659 ccomp was,showed
R1373 T5662 T5663 det this,cDNA
R1374 T5663 T5661 nsubj cDNA,was
R1375 T5664 T5665 det a,gene
R1376 T5665 T5661 attr gene,was
R1377 T5666 T5665 amod novel,gene
R1378 T5667 T5665 acl encoding,gene
R1379 T5668 T5669 det a,protein
R1380 T5669 T5667 dobj protein,encoding
R1381 T5670 T5671 compound SAM,domain
R1382 T5671 T5672 npadvmod domain,containing
R1383 T5672 T5669 amod containing,protein
R1384 T5673 T5672 punct -,containing
R1385 T5674 T5659 punct .,showed
R1386 T5676 T5677 nsubj We,referred
R1387 T5678 T5677 prep to,referred
R1388 T5679 T5680 det this,protein
R1389 T5680 T5678 pobj protein,to
R1390 T5681 T5677 prep as,referred
R1391 T5682 T5683 compound mr,s
R1392 T5683 T5681 pobj s,as
R1393 T5684 T5683 punct -,s
R1394 T5685 T5683 punct (,s
R1395 T5686 T5687 amod major,protein
R1396 T5687 T5683 appos protein,s
R1397 T5688 T5687 amod retinal,protein
R1398 T5689 T5690 compound SAM,domain
R1399 T5690 T5687 compound domain,protein
R1400 T5691 T5677 punct ),referred
R1401 T5692 T5677 punct .,referred
R1402 T5694 T5695 mark As,shown
R1403 T5695 T5696 advcl shown,is
R1404 T5697 T5695 prep in,shown
R1405 T5698 T5699 compound Fig.,1A
R1406 T5699 T5697 pobj 1A,in
R1407 T5700 T5696 punct ", ",is
R1408 T5701 T5702 det a,codon
R1409 T5702 T5696 nsubj codon,is
R1410 T5703 T5702 compound translation,codon
R1411 T5704 T5702 compound initiation,codon
R1412 T5705 T5696 acomp present,is
R1413 T5706 T5696 prep in,is
R1414 T5707 T5708 det the,frame
R1415 T5708 T5706 pobj frame,in
R1416 T5709 T5708 amod same,frame
R1417 T5710 T5708 amod open,frame
R1418 T5711 T5708 compound reading,frame
R1419 T5712 T5708 prep as,frame
R1420 T5713 T5714 det the,domain
R1421 T5714 T5712 pobj domain,as
R1422 T5715 T5714 compound SAM,domain
R1423 T5716 T5696 punct .,is
R1424 T5718 T5719 det This,site
R1425 T5719 T5721 nsubj site,shows
R1426 T5720 T5719 compound initiation,site
R1427 T5722 T5721 dobj similarity,shows
R1428 T5723 T5722 prep to,similarity
R1429 T5724 T5725 det the,sequence
R1430 T5725 T5723 pobj sequence,to
R1431 T5726 T5725 compound consensus,sequence
R1432 T5727 T5725 acl proposed,sequence
R1433 T5728 T5727 agent by,proposed
R1434 T5729 T5728 pobj Kozak,by
R1435 T5730 T5731 punct [,32
R1436 T5731 T5729 parataxis 32,Kozak
R1437 T5732 T5731 punct ],32
R1438 T5733 T5725 prep including,sequence
R1439 T5734 T5735 det the,presence
R1440 T5735 T5733 pobj presence,including
R1441 T5736 T5735 prep of,presence
R1442 T5737 T5738 det the,purine
R1443 T5738 T5736 pobj purine,of
R1444 T5739 T5740 advmod highly,conserved
R1445 T5740 T5738 amod conserved,purine
R1446 T5741 T5735 prep at,presence
R1447 T5742 T5741 pobj position,at
R1448 T5743 T5742 punct -,position
R1449 T5744 T5742 nummod 3,position
R1450 T5745 T5721 punct .,shows
R1451 T5747 T5748 det The,codon
R1452 T5748 T5750 nsubjpass codon,indicated
R1453 T5749 T5748 compound stop,codon
R1454 T5751 T5748 prep of,codon
R1455 T5752 T5753 det the,protein
R1456 T5753 T5751 pobj protein,of
R1457 T5754 T5753 amod predicted,protein
R1458 T5755 T5756 compound mr,s
R1459 T5756 T5753 compound s,protein
R1460 T5757 T5756 punct -,s
R1461 T5758 T5750 auxpass is,indicated
R1462 T5759 T5750 advmod also,indicated
R1463 T5760 T5750 prep in,indicated
R1464 T5761 T5762 compound Fig.,1A
R1465 T5762 T5760 pobj 1A,in
R1466 T5763 T5750 punct .,indicated
R1467 T5765 T5766 det The,sequence
R1468 T5766 T5769 nsubj sequence,exhibits
R1469 T5767 T5768 compound amino,acid
R1470 T5768 T5766 compound acid,sequence
R1471 T5770 T5766 prep of,sequence
R1472 T5771 T5772 det the,domain
R1473 T5772 T5770 pobj domain,of
R1474 T5773 T5772 compound SAM,domain
R1475 T5774 T5772 prep of,domain
R1476 T5775 T5776 compound mr,s
R1477 T5776 T5778 compound s,protein
R1478 T5777 T5776 punct -,s
R1479 T5778 T5774 pobj protein,of
R1480 T5779 T5780 punct (,1A
R1481 T5780 T5766 parataxis 1A,sequence
R1482 T5781 T5780 compound Fig.,1A
R1483 T5782 T5780 punct ", ",1A
R1484 T5783 T5784 amod boxed,sequence
R1485 T5784 T5780 appos sequence,1A
R1486 T5785 T5780 punct ),1A
R1487 T5786 T5769 dobj homology,exhibits
R1488 T5787 T5786 prep with,homology
R1489 T5788 T5789 compound SAM,domains
R1490 T5789 T5787 pobj domains,with
R1491 T5790 T5789 prep of,domains
R1492 T5791 T5790 pobj EphB2,of
R1493 T5792 T5791 punct ", ",EphB2
R1494 T5793 T5791 conj EphA4,EphB2
R1495 T5794 T5793 punct ", ",EphA4
R1496 T5795 T5793 conj MPH1,EphA4
R1497 T5796 T5795 punct ", ",MPH1
R1498 T5797 T5795 conj TEL,MPH1
R1499 T5798 T5797 cc and,TEL
R1500 T5799 T5797 conj Smaug,TEL
R1501 T5800 T5801 punct (,1B
R1502 T5801 T5769 parataxis 1B,exhibits
R1503 T5802 T5801 compound Fig.,1B
R1504 T5803 T5801 punct ),1B
R1505 T5804 T5769 punct .,exhibits
R1506 T5806 T5807 prep By,related
R1507 T5808 T5809 amod phylogenetic,analysis
R1508 T5809 T5806 pobj analysis,By
R1509 T5810 T5807 punct ", ",related
R1510 T5811 T5812 det the,domain
R1511 T5812 T5807 nsubjpass domain,related
R1512 T5813 T5812 compound SAM,domain
R1513 T5814 T5812 prep of,domain
R1514 T5815 T5816 compound mr,s
R1515 T5816 T5814 pobj s,of
R1516 T5817 T5816 punct -,s
R1517 T5818 T5807 auxpass is,related
R1518 T5819 T5820 advmod most,closely
R1519 T5820 T5807 advmod closely,related
R1520 T5821 T5807 prep to,related
R1521 T5822 T5821 pobj that,to
R1522 T5823 T5822 prep of,that
R1523 T5824 T5825 compound Mph1,Rae28
R1524 T5825 T5823 pobj Rae28,of
R1525 T5826 T5825 punct /,Rae28
R1526 T5827 T5825 punct ", ",Rae28
R1527 T5828 T5829 det a,homolog
R1528 T5829 T5825 appos homolog,Rae28
R1529 T5830 T5829 compound mouse,homolog
R1530 T5831 T5829 prep of,homolog
R1531 T5832 T5831 pobj ph,of
R1532 T5833 T5834 punct (,1C
R1533 T5834 T5807 parataxis 1C,related
R1534 T5835 T5834 compound Fig.,1C
R1535 T5836 T5834 punct ),1C
R1536 T5837 T5807 punct .,related
R1537 T5839 T5840 compound Mouse,protein
R1538 T5840 T5844 nsubjpass protein,conserved
R1539 T5841 T5842 compound mr,s
R1540 T5842 T5840 compound s,protein
R1541 T5843 T5842 punct -,s
R1542 T5845 T5844 auxpass is,conserved
R1543 T5846 T5844 prep in,conserved
R1544 T5847 T5846 pobj rat,in
R1545 T5848 T5847 punct ", ",rat
R1546 T5849 T5847 amod human,rat
R1547 T5850 T5847 punct ", ",rat
R1548 T5851 T5847 conj chick,rat
R1549 T5852 T5851 cc and,chick
R1550 T5853 T5851 conj zebrafish,chick
R1551 T5854 T5847 punct ", ",rat
R1552 T5855 T5856 dep which,display
R1553 T5856 T5847 relcl display,rat
R1554 T5857 T5858 nummod 91,%
R1555 T5858 T5859 nmod %,identity
R1556 T5859 T5856 dobj identity,display
R1557 T5860 T5858 punct ", ",%
R1558 T5861 T5862 nummod 70,%
R1559 T5862 T5858 conj %,%
R1560 T5863 T5862 punct ", ",%
R1561 T5864 T5865 nummod 36,%
R1562 T5865 T5862 conj %,%
R1563 T5866 T5865 cc and,%
R1564 T5867 T5868 nummod 26,%
R1565 T5868 T5865 conj %,%
R1566 T5869 T5859 prep with,identity
R1567 T5870 T5871 compound mouse,s
R1568 T5871 T5869 pobj s,with
R1569 T5872 T5871 compound mr,s
R1570 T5873 T5871 punct -,s
R1571 T5874 T5856 punct ", ",display
R1572 T5875 T5856 advmod respectively,display
R1573 T5876 T5877 punct (,1D
R1574 T5877 T5844 parataxis 1D,conserved
R1575 T5878 T5877 compound Fig.,1D
R1576 T5879 T5877 punct ),1D
R1577 T5880 T5844 punct .,conserved
R1578 T5882 T5883 det The,domains
R1579 T5883 T5885 nsubjpass domains,conserved
R1580 T5884 T5883 compound SAM,domains
R1581 T5886 T5883 prep of,domains
R1582 T5887 T5888 nmod rat,protein
R1583 T5888 T5886 pobj protein,of
R1584 T5889 T5887 punct ", ",rat
R1585 T5890 T5887 amod human,rat
R1586 T5891 T5887 punct ", ",rat
R1587 T5892 T5887 conj chick,rat
R1588 T5893 T5892 cc and,chick
R1589 T5894 T5892 conj zebrafish,chick
R1590 T5895 T5896 compound mr,s
R1591 T5896 T5888 compound s,protein
R1592 T5897 T5896 punct -,s
R1593 T5898 T5885 auxpass are,conserved
R1594 T5899 T5885 advmod highly,conserved
R1595 T5900 T5885 cc and,conserved
R1596 T5901 T5885 conj display,conserved
R1597 T5902 T5903 nummod 96,%
R1598 T5903 T5904 nmod %,identity
R1599 T5904 T5901 dobj identity,display
R1600 T5905 T5903 punct ", ",%
R1601 T5906 T5907 nummod 90,%
R1602 T5907 T5903 conj %,%
R1603 T5908 T5907 punct ", ",%
R1604 T5909 T5910 nummod 76,%
R1605 T5910 T5907 conj %,%
R1606 T5911 T5910 cc and,%
R1607 T5912 T5913 nummod 72,%
R1608 T5913 T5910 conj %,%
R1609 T5914 T5904 prep with,identity
R1610 T5915 T5916 det the,domain
R1611 T5916 T5914 pobj domain,with
R1612 T5917 T5916 compound SAM,domain
R1613 T5918 T5916 prep of,domain
R1614 T5919 T5920 compound mouse,protein
R1615 T5920 T5918 pobj protein,of
R1616 T5921 T5922 compound mr,s
R1617 T5922 T5920 compound s,protein
R1618 T5923 T5922 punct -,s
R1619 T5924 T5885 punct .,conserved
R1620 T5926 T5927 det The,localizations
R1621 T5927 T5929 nsubjpass localizations,determined
R1622 T5928 T5927 amod chromosomal,localizations
R1623 T5930 T5927 prep of,localizations
R1624 T5931 T5932 nmod mouse,genes
R1625 T5932 T5930 pobj genes,of
R1626 T5933 T5931 cc and,mouse
R1627 T5934 T5931 conj human,mouse
R1628 T5935 T5936 compound mr,s
R1629 T5936 T5932 compound s,genes
R1630 T5937 T5936 punct -,s
R1631 T5938 T5929 auxpass were,determined
R1632 T5939 T5929 prep by,determined
R1633 T5940 T5939 pcomp searching,by
R1634 T5941 T5942 det the,databases
R1635 T5942 T5940 dobj databases,searching
R1636 T5943 T5942 nmod mouse,databases
R1637 T5944 T5943 cc and,mouse
R1638 T5945 T5943 conj human,mouse
R1639 T5946 T5942 compound genome,databases
R1640 T5947 T5948 punct (,NCBI
R1641 T5948 T5942 parataxis NCBI,databases
R1642 T5949 T5948 punct ),NCBI
R1643 T5950 T5940 punct ", ",searching
R1644 T5951 T5940 advmod respectively,searching
R1645 T5952 T5929 punct .,determined
R1646 T5954 T5955 compound Mouse,s
R1647 T5955 T5958 nsubjpass s,mapped
R1648 T5956 T5955 compound mr,s
R1649 T5957 T5955 punct -,s
R1650 T5959 T5958 auxpass is,mapped
R1651 T5960 T5958 prep to,mapped
R1652 T5961 T5962 compound chromosome,4E2
R1653 T5962 T5960 pobj 4E2,to
R1654 T5963 T5958 punct ", ",mapped
R1655 T5964 T5958 cc and,mapped
R1656 T5965 T5966 amod human,S
R1657 T5966 T5969 nsubjpass S,mapped
R1658 T5967 T5966 compound MR,S
R1659 T5968 T5966 punct -,S
R1660 T5969 T5958 conj mapped,mapped
R1661 T5970 T5969 auxpass is,mapped
R1662 T5971 T5969 prep to,mapped
R1663 T5972 T5973 compound chromosome,1p36.33
R1664 T5973 T5971 pobj 1p36.33,to
R1665 T5974 T5969 punct .,mapped
R1666 T5976 T5977 nsubj LCA,is
R1667 T5978 T5979 det the,cause
R1668 T5979 T5977 attr cause,is
R1669 T5980 T5981 advmod most,common
R1670 T5981 T5979 amod common,cause
R1671 T5982 T5979 prep of,cause
R1672 T5983 T5984 amod inherited,blindness
R1673 T5984 T5982 pobj blindness,of
R1674 T5985 T5984 compound childhood,blindness
R1675 T5986 T5977 punct .,is
R1676 T5988 T5989 amod Human,S
R1677 T5989 T5992 nsubj S,maps
R1678 T5990 T5989 compound MR,S
R1679 T5991 T5989 punct -,S
R1680 T5993 T5992 prep in,maps
R1681 T5994 T5995 det the,region
R1682 T5995 T5993 pobj region,in
R1683 T5996 T5995 compound vicinity,region
R1684 T5997 T5995 prep of,region
R1685 T5998 T5999 det the,LCA9
R1686 T5999 T5997 pobj LCA9,of
R1687 T6000 T5999 punct ", ",LCA9
R1688 T6001 T6002 advmod recently,identified
R1689 T6002 T5999 acl identified,LCA9
R1690 T6003 T6002 prep as,identified
R1691 T6004 T6005 det a,locus
R1692 T6005 T6003 pobj locus,as
R1693 T6006 T6005 amod new,locus
R1694 T6007 T6005 prep for,locus
R1695 T6008 T6007 pobj LCA,for
R1696 T6009 T6010 punct [,33
R1697 T6010 T5992 parataxis 33,maps
R1698 T6011 T6010 punct ],33
R1699 T6012 T5992 punct .,maps
R8157 T28701 T28702 nmod mr,s
R8158 T28702 T28704 nmod s,nucleotide
R8159 T28703 T28702 punct -,s
R8160 T28704 T28705 nmod nucleotide,sequences
R8161 T28706 T28704 cc and,nucleotide
R8162 T28707 T28708 compound amino,acid
R8163 T28708 T28704 conj acid,nucleotide
R8164 T28709 T28705 punct .,sequences
R8165 T28711 T28712 punct (,A
R8166 T28712 T28713 meta A,sequences
R8167 T28714 T28712 punct ),A
R8168 T28715 T28716 nmod mr,s
R8169 T28716 T28718 nmod s,nucleotide
R8170 T28717 T28716 punct -,s
R8171 T28718 T28713 nmod nucleotide,sequences
R8172 T28719 T28718 cc and,nucleotide
R8173 T28720 T28721 compound amino,acids
R8174 T28721 T28718 conj acids,nucleotide
R8175 T28722 T28713 punct .,sequences
R8176 T28724 T28725 amod Boxed,acids
R8177 T28725 T28727 nsubj acids,are
R8178 T28726 T28725 compound amino,acids
R8179 T28728 T28729 det the,sequence
R8180 T28729 T28727 attr sequence,are
R8181 T28730 T28731 compound SAM,domain
R8182 T28731 T28729 compound domain,sequence
R8183 T28732 T28727 cc and,are
R8184 T28733 T28734 det the,box
R8185 T28734 T28736 nsubj box,indicates
R8186 T28735 T28734 amod dashed,box
R8187 T28736 T28727 conj indicates,are
R8188 T28737 T28738 det a,signal
R8189 T28738 T28736 dobj signal,indicates
R8190 T28739 T28738 amod putative,signal
R8191 T28740 T28741 amod nuclear,localization
R8192 T28741 T28738 compound localization,signal
R8193 T28742 T28736 punct .,indicates
R8194 T28744 T28745 det The,underline
R8195 T28745 T28746 nsubj underline,indicates
R8196 T28747 T28748 det a,signal
R8197 T28748 T28746 dobj signal,indicates
R8198 T28749 T28748 amod putative,signal
R8199 T28750 T28751 compound polyadenylation,termination
R8200 T28751 T28748 compound termination,signal
R8201 T28752 T28746 punct .,indicates
R8202 T28754 T28755 punct (,B
R8203 T28755 T28756 meta B,Alignment
R8204 T28757 T28755 punct ),B
R8205 T28758 T28756 prep of,Alignment
R8206 T28759 T28760 compound SAM,domain
R8207 T28760 T28761 compound domain,sequences
R8208 T28761 T28758 pobj sequences,of
R8209 T28762 T28761 prep for,sequences
R8210 T28763 T28764 compound SAM,domain
R8211 T28764 T28765 npadvmod domain,containing
R8212 T28765 T28767 amod containing,proteins
R8213 T28766 T28765 punct -,containing
R8214 T28767 T28762 pobj proteins,for
R8215 T28768 T28756 punct .,Alignment
R8216 T28770 T28771 det The,helices
R8217 T28771 T28774 nsubjpass helices,marked
R8218 T28772 T28771 nummod five,helices
R8219 T28773 T28771 compound alpha,helices
R8220 T28775 T28774 auxpass are,marked
R8221 T28776 T28774 oprd H1,marked
R8222 T28777 T28778 punct -,H5
R8223 T28778 T28776 prep H5,H1
R8224 T28779 T28774 punct .,marked
R8225 T28781 T28782 amod Conserved,residues
R8226 T28782 T28785 nsubjpass residues,shown
R8227 T28783 T28784 compound amino,acid
R8228 T28784 T28782 compound acid,residues
R8229 T28786 T28785 auxpass are,shown
R8230 T28787 T28785 prep with,shown
R8231 T28788 T28789 det a,shadow
R8232 T28789 T28787 pobj shadow,with
R8233 T28790 T28789 amod dark,shadow
R8234 T28791 T28785 cc and,shown
R8235 T28792 T28793 advmod functionally,similar
R8236 T28793 T28794 amod similar,residues
R8237 T28794 T28795 nsubjpass residues,shown
R8238 T28795 T28785 conj shown,shown
R8239 T28796 T28795 auxpass are,shown
R8240 T28797 T28795 prep with,shown
R8241 T28798 T28799 det a,shadow
R8242 T28799 T28797 pobj shadow,with
R8243 T28800 T28799 amod light,shadow
R8244 T28801 T28795 punct .,shown
R8245 T28803 T28804 det The,sites
R8246 T28804 T28805 nsubjpass sites,indicated
R8247 T28806 T28807 dep that,targeted
R8248 T28807 T28804 relcl targeted,sites
R8249 T28808 T28807 auxpass were,targeted
R8250 T28809 T28807 prep for,targeted
R8251 T28810 T28809 pobj mutagenesis,for
R8252 T28811 T28805 auxpass are,indicated
R8253 T28812 T28805 prep by,indicated
R8254 T28813 T28812 pobj arrows,by
R8255 T28814 T28805 punct .,indicated
R8256 T28816 T28817 punct (,C
R8257 T28817 T28818 meta C,tree
R8258 T28819 T28817 punct ),C
R8259 T28820 T28818 amod Phylogenetic,tree
R8260 T28821 T28818 prep of,tree
R8261 T28822 T28823 compound SAM,domain
R8262 T28823 T28824 npadvmod domain,containing
R8263 T28824 T28826 amod containing,proteins
R8264 T28825 T28824 punct -,containing
R8265 T28826 T28821 pobj proteins,of
R8266 T28827 T28818 punct .,tree
R8267 T28829 T28830 compound Amino,acid
R8268 T28830 T28831 compound acid,sequences
R8269 T28831 T28832 nsubjpass sequences,analyzed
R8270 T28833 T28832 auxpass were,analyzed
R8271 T28834 T28832 prep by,analyzed
R8272 T28835 T28836 det the,method
R8273 T28836 T28834 pobj method,by
R8274 T28837 T28838 npadvmod neighbor,joining
R8275 T28838 T28836 amod joining,method
R8276 T28839 T28838 punct -,joining
R8277 T28840 T28832 prep in,analyzed
R8278 T28841 T28840 pobj MacVector,in
R8279 T28842 T28841 nummod 7.2,MacVector
R8280 T28843 T28832 punct .,analyzed
R8281 T28845 T28846 compound Branch,lengths
R8282 T28846 T28847 nsubj lengths,reflect
R8283 T28848 T28849 det the,number
R8284 T28849 T28847 dobj number,reflect
R8285 T28850 T28849 compound mean,number
R8286 T28851 T28849 prep of,number
R8287 T28852 T28851 pobj substitutions,of
R8288 T28853 T28852 prep per,substitutions
R8289 T28854 T28853 pobj site,per
R8290 T28855 T28847 punct .,reflect
R8291 T28857 T28858 punct (,D
R8292 T28858 T28859 meta D,comparison
R8293 T28860 T28858 punct ),D
R8294 T28861 T28859 amod Schematic,comparison
R8295 T28862 T28859 prep of,comparison
R8296 T28863 T28864 det the,sequences
R8297 T28864 T28862 pobj sequences,of
R8298 T28865 T28866 compound amino,acid
R8299 T28866 T28864 compound acid,sequences
R8300 T28867 T28864 prep for,sequences
R8301 T28868 T28869 nmod mouse,proteins
R8302 T28869 T28867 pobj proteins,for
R8303 T28870 T28868 punct ", ",mouse
R8304 T28871 T28868 conj rat,mouse
R8305 T28872 T28871 punct ", ",rat
R8306 T28873 T28871 amod human,rat
R8307 T28874 T28871 punct ", ",rat
R8308 T28875 T28871 conj chick,rat
R8309 T28876 T28875 cc and,chick
R8310 T28877 T28875 conj zebrafish,chick
R8311 T28878 T28879 compound mr,s
R8312 T28879 T28869 compound s,proteins
R8313 T28880 T28879 punct -,s
R8314 T28881 T28859 punct .,comparison
R8315 T28883 T28884 det The,similarity
R8316 T28884 T28886 nsubjpass similarity,shown
R8317 T28885 T28884 compound percent,similarity
R8318 T28887 T28884 prep of,similarity
R8319 T28888 T28889 det the,domains
R8320 T28889 T28887 pobj domains,of
R8321 T28890 T28889 compound SAM,domains
R8322 T28891 T28889 cc and,domains
R8323 T28892 T28893 amod other,regions
R8324 T28893 T28889 conj regions,domains
R8325 T28894 T28884 prep to,similarity
R8326 T28895 T28896 det the,regions
R8327 T28896 T28894 pobj regions,to
R8328 T28897 T28896 amod corresponding,regions
R8329 T28898 T28896 prep of,regions
R8330 T28899 T28900 det the,protein
R8331 T28900 T28898 pobj protein,of
R8332 T28901 T28900 compound mouse,protein
R8333 T28902 T28886 auxpass is,shown
R8334 T28903 T28886 punct .,shown
R8335 T28905 T28906 amod Overall,similarity
R8336 T28906 T28908 nsubjpass similarity,shown
R8337 T28907 T28906 compound sequence,similarity
R8338 T28909 T28906 prep with,similarity
R8339 T28910 T28911 det the,protein
R8340 T28911 T28909 pobj protein,with
R8341 T28912 T28911 compound mouse,protein
R8342 T28913 T28908 auxpass is,shown
R8343 T28914 T28908 prep on,shown
R8344 T28915 T28916 det the,right
R8345 T28916 T28914 pobj right,on
R8346 T28917 T28908 punct .,shown