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PMC:1435744 / 32096-33206 JSONTXT 4 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T20821 0-2 PRP denotes We
T20823 3-13 RB denotes previously
T20822 14-22 VBD denotes reported
T20824 23-27 IN denotes that
T20826 28-32 NN denotes Otx2
T20827 33-36 CC denotes and
T20828 37-40 NN denotes Crx
T20825 41-45 VBP denotes have
T20829 46-47 DT denotes a
T20831 48-56 JJ denotes critical
T20830 57-61 NN denotes role
T20832 62-64 IN denotes in
T20833 65-78 NN denotes photoreceptor
T20834 79-90 NN denotes development
T20835 91-94 CC denotes and
T20836 95-99 IN denotes that
T20838 100-104 NN denotes Otx2
T20839 105-113 RB denotes directly
T20837 114-123 VBZ denotes regulates
T20840 124-127 NN denotes Crx
T20841 128-141 NN denotes transcription
T20842 142-143 -LRB- denotes [
T20844 143-144 CD denotes 3
T20845 144-145 , denotes ,
T20843 145-146 CD denotes 9
T20846 146-147 -RRB- denotes ]
T20847 147-148 . denotes .
T20848 148-264 sentence denotes In situ hybridization and RT-PCR showed significant reduction of mr-s signal in the Crx KO retina and pineal gland.
T20849 149-151 FW denotes In
T20850 152-156 FW denotes situ
T20851 157-170 NN denotes hybridization
T20853 171-174 CC denotes and
T20854 175-177 NN denotes RT
T20856 177-178 HYPH denotes -
T20855 178-181 NN denotes PCR
T20852 182-188 VBD denotes showed
T20857 189-200 JJ denotes significant
T20858 201-210 NN denotes reduction
T20859 211-213 IN denotes of
T20860 214-216 NN denotes mr
T20862 216-217 HYPH denotes -
T20861 217-218 NN denotes s
T20863 219-225 NN denotes signal
T20864 226-228 IN denotes in
T20865 229-232 DT denotes the
T20867 233-236 NN denotes Crx
T20866 237-239 NN denotes KO
T20868 240-246 NN denotes retina
T20869 247-250 CC denotes and
T20870 251-257 JJ denotes pineal
T20871 258-263 NN denotes gland
T20872 263-264 . denotes .
T20873 264-399 sentence denotes Furthermore, the luciferase assay demonstrated that Otx2 and Crx may directly upregulate the transcription of mr-s in mammalian cells.
T20874 265-276 RB denotes Furthermore
T20876 276-278 , denotes ,
T20877 278-281 DT denotes the
T20879 282-292 NN denotes luciferase
T20878 293-298 NN denotes assay
T20875 299-311 VBD denotes demonstrated
T20880 312-316 IN denotes that
T20882 317-321 NN denotes Otx2
T20883 322-325 CC denotes and
T20884 326-329 NN denotes Crx
T20885 330-333 MD denotes may
T20886 334-342 RB denotes directly
T20881 343-353 VB denotes upregulate
T20887 354-357 DT denotes the
T20888 358-371 NN denotes transcription
T20889 372-374 IN denotes of
T20890 375-377 NN denotes mr
T20892 377-378 HYPH denotes -
T20891 378-379 NN denotes s
T20893 380-382 IN denotes in
T20894 383-392 JJ denotes mammalian
T20895 393-398 NNS denotes cells
T20896 398-399 . denotes .
T20897 399-546 sentence denotes In retinal photoreceptor cells, the Otx2 transcripts are not highly expressed at P6-P9, while the Crx transcripts are strongly detected around P6.
T20898 400-402 IN denotes In
T20900 403-410 JJ denotes retinal
T20902 411-424 NN denotes photoreceptor
T20901 425-430 NNS denotes cells
T20903 430-432 , denotes ,
T20904 432-435 DT denotes the
T20906 436-440 NN denotes Otx2
T20905 441-452 NNS denotes transcripts
T20899 453-456 VBP denotes are
T20907 457-460 RB denotes not
T20908 461-467 RB denotes highly
T20909 468-477 JJ denotes expressed
T20910 478-480 IN denotes at
T20911 481-483 NN denotes P6
T20912 483-484 SYM denotes -
T20913 484-486 NN denotes P9
T20914 486-488 , denotes ,
T20915 488-493 IN denotes while
T20917 494-497 DT denotes the
T20919 498-501 NN denotes Crx
T20918 502-513 NNS denotes transcripts
T20920 514-517 VBP denotes are
T20921 518-526 RB denotes strongly
T20916 527-535 VBN denotes detected
T20922 536-542 IN denotes around
T20923 543-545 NN denotes P6
T20924 545-546 . denotes .
T20925 546-640 sentence denotes Therefore, our results strongly suggest that mr-s transcription is directly regulated by Crx.
T20926 547-556 RB denotes Therefore
T20928 556-558 , denotes ,
T20929 558-561 PRP$ denotes our
T20930 562-569 NNS denotes results
T20931 570-578 RB denotes strongly
T20927 579-586 VBP denotes suggest
T20932 587-591 IN denotes that
T20934 592-594 NN denotes mr
T20936 594-595 HYPH denotes -
T20935 595-596 NN denotes s
T20937 597-610 NN denotes transcription
T20938 611-613 VBZ denotes is
T20939 614-622 RB denotes directly
T20933 623-632 VBN denotes regulated
T20940 633-635 IN denotes by
T20941 636-639 NN denotes Crx
T20942 639-640 . denotes .
T20943 640-822 sentence denotes In the present study, Nrl, a photoreceptor-specific transcription factor that is highly expressed in photoreceptors at the postnatal stage, did not affect the transcription of mr-s.
T20944 641-643 IN denotes In
T20946 644-647 DT denotes the
T20948 648-655 JJ denotes present
T20947 656-661 NN denotes study
T20949 661-663 , denotes ,
T20950 663-666 NN denotes Nrl
T20951 666-668 , denotes ,
T20952 668-669 DT denotes a
T20954 670-683 NN denotes photoreceptor
T20956 683-684 HYPH denotes -
T20955 684-692 JJ denotes specific
T20957 693-706 NN denotes transcription
T20953 707-713 NN denotes factor
T20958 714-718 WDT denotes that
T20960 719-721 VBZ denotes is
T20961 722-728 RB denotes highly
T20959 729-738 VBN denotes expressed
T20962 739-741 IN denotes in
T20963 742-756 NNS denotes photoreceptors
T20964 757-759 IN denotes at
T20965 760-763 DT denotes the
T20967 764-773 JJ denotes postnatal
T20966 774-779 NN denotes stage
T20968 779-781 , denotes ,
T20969 781-784 VBD denotes did
T20970 785-788 RB denotes not
T20945 789-795 VB denotes affect
T20971 796-799 DT denotes the
T20972 800-813 NN denotes transcription
T20973 814-816 IN denotes of
T20974 817-819 NN denotes mr
T20976 819-820 HYPH denotes -
T20975 820-821 NN denotes s
T20977 821-822 . denotes .
T20978 822-930 sentence denotes This finding is actually consistent with the analysis of the Nrl KO mouse which was recently reported [40].
T20979 823-827 DT denotes This
T20980 828-835 NN denotes finding
T20981 836-838 VBZ denotes is
T20982 839-847 RB denotes actually
T20983 848-858 JJ denotes consistent
T20984 859-863 IN denotes with
T20985 864-867 DT denotes the
T20986 868-876 NN denotes analysis
T20987 877-879 IN denotes of
T20988 880-883 DT denotes the
T20990 884-887 NN denotes Nrl
T20991 888-890 NN denotes KO
T20989 891-896 NN denotes mouse
T20992 897-902 WDT denotes which
T20994 903-906 VBD denotes was
T20995 907-915 RB denotes recently
T20993 916-924 VBN denotes reported
T20996 925-926 -LRB- denotes [
T20997 926-928 CD denotes 40
T20998 928-929 -RRB- denotes ]
T20999 929-930 . denotes .
T21000 930-1110 sentence denotes The expression profiles of wild-type and Nrl KO retinas at P2, P10 and 2 months were analyzed and mr-s was not included in 161 differentially expressed genes in the Nrl KO retina.
T21001 931-934 DT denotes The
T21003 935-945 NN denotes expression
T21002 946-954 NNS denotes profiles
T21005 955-957 IN denotes of
T21006 958-962 JJ denotes wild
T21008 962-963 HYPH denotes -
T21007 963-967 NN denotes type
T21010 968-971 CC denotes and
T21011 972-975 NN denotes Nrl
T21012 976-978 NN denotes KO
T21009 979-986 NNS denotes retinas
T21013 987-989 IN denotes at
T21014 990-992 NN denotes P2
T21015 992-994 , denotes ,
T21016 994-997 NN denotes P10
T21017 998-1001 CC denotes and
T21018 1002-1003 CD denotes 2
T21019 1004-1010 NNS denotes months
T21020 1011-1015 VBD denotes were
T21004 1016-1024 VBN denotes analyzed
T21021 1025-1028 CC denotes and
T21022 1029-1031 NN denotes mr
T21024 1031-1032 HYPH denotes -
T21023 1032-1033 NN denotes s
T21026 1034-1037 VBD denotes was
T21027 1038-1041 RB denotes not
T21025 1042-1050 VBN denotes included
T21028 1051-1053 IN denotes in
T21029 1054-1057 CD denotes 161
T21031 1058-1072 RB denotes differentially
T21032 1073-1082 VBN denotes expressed
T21030 1083-1088 NNS denotes genes
T21033 1089-1091 IN denotes in
T21034 1092-1095 DT denotes the
T21036 1096-1099 NN denotes Nrl
T21037 1100-1102 NN denotes KO
T21035 1103-1109 NN denotes retina
T21038 1109-1110 . denotes .
R4991 T20821 T20822 nsubj We,reported
R4992 T20823 T20822 advmod previously,reported
R4993 T20824 T20825 mark that,have
R4994 T20825 T20822 advcl have,reported
R4995 T20826 T20825 nsubj Otx2,have
R4996 T20827 T20826 cc and,Otx2
R4997 T20828 T20826 conj Crx,Otx2
R4998 T20829 T20830 det a,role
R4999 T20830 T20825 dobj role,have
R5000 T20831 T20830 amod critical,role
R5001 T20832 T20830 prep in,role
R5002 T20833 T20834 compound photoreceptor,development
R5003 T20834 T20832 pobj development,in
R5004 T20835 T20825 cc and,have
R5005 T20836 T20837 mark that,regulates
R5006 T20837 T20825 conj regulates,have
R5007 T20838 T20837 nsubj Otx2,regulates
R5008 T20839 T20837 advmod directly,regulates
R5009 T20840 T20841 compound Crx,transcription
R5010 T20841 T20837 dobj transcription,regulates
R5011 T20842 T20843 punct [,9
R5012 T20843 T20822 parataxis 9,reported
R5013 T20844 T20843 nummod 3,9
R5014 T20845 T20843 punct ",",9
R5015 T20846 T20843 punct ],9
R5016 T20847 T20822 punct .,reported
R5017 T20849 T20850 advmod In,situ
R5018 T20850 T20851 amod situ,hybridization
R5019 T20851 T20852 nsubj hybridization,showed
R5020 T20853 T20851 cc and,hybridization
R5021 T20854 T20855 compound RT,PCR
R5022 T20855 T20851 conj PCR,hybridization
R5023 T20856 T20855 punct -,PCR
R5024 T20857 T20858 amod significant,reduction
R5025 T20858 T20852 dobj reduction,showed
R5026 T20859 T20858 prep of,reduction
R5027 T20860 T20861 compound mr,s
R5028 T20861 T20863 compound s,signal
R5029 T20862 T20861 punct -,s
R5030 T20863 T20859 pobj signal,of
R5031 T20864 T20852 prep in,showed
R5032 T20865 T20866 det the,KO
R5033 T20866 T20864 pobj KO,in
R5034 T20867 T20866 compound Crx,KO
R5035 T20868 T20866 appos retina,KO
R5036 T20869 T20868 cc and,retina
R5037 T20870 T20871 amod pineal,gland
R5038 T20871 T20868 conj gland,retina
R5039 T20872 T20852 punct .,showed
R5040 T20874 T20875 advmod Furthermore,demonstrated
R5041 T20876 T20875 punct ", ",demonstrated
R5042 T20877 T20878 det the,assay
R5043 T20878 T20875 nsubj assay,demonstrated
R5044 T20879 T20878 compound luciferase,assay
R5045 T20880 T20881 mark that,upregulate
R5046 T20881 T20875 ccomp upregulate,demonstrated
R5047 T20882 T20881 nsubj Otx2,upregulate
R5048 T20883 T20882 cc and,Otx2
R5049 T20884 T20882 conj Crx,Otx2
R5050 T20885 T20881 aux may,upregulate
R5051 T20886 T20881 advmod directly,upregulate
R5052 T20887 T20888 det the,transcription
R5053 T20888 T20881 dobj transcription,upregulate
R5054 T20889 T20888 prep of,transcription
R5055 T20890 T20891 compound mr,s
R5056 T20891 T20889 pobj s,of
R5057 T20892 T20891 punct -,s
R5058 T20893 T20881 prep in,upregulate
R5059 T20894 T20895 amod mammalian,cells
R5060 T20895 T20893 pobj cells,in
R5061 T20896 T20875 punct .,demonstrated
R5062 T20898 T20899 prep In,are
R5063 T20900 T20901 amod retinal,cells
R5064 T20901 T20898 pobj cells,In
R5065 T20902 T20901 compound photoreceptor,cells
R5066 T20903 T20899 punct ", ",are
R5067 T20904 T20905 det the,transcripts
R5068 T20905 T20899 nsubj transcripts,are
R5069 T20906 T20905 compound Otx2,transcripts
R5070 T20907 T20899 neg not,are
R5071 T20908 T20909 advmod highly,expressed
R5072 T20909 T20899 acomp expressed,are
R5073 T20910 T20899 prep at,are
R5074 T20911 T20910 pobj P6,at
R5075 T20912 T20913 punct -,P9
R5076 T20913 T20911 prep P9,P6
R5077 T20914 T20899 punct ", ",are
R5078 T20915 T20916 mark while,detected
R5079 T20916 T20899 advcl detected,are
R5080 T20917 T20918 det the,transcripts
R5081 T20918 T20916 nsubjpass transcripts,detected
R5082 T20919 T20918 compound Crx,transcripts
R5083 T20920 T20916 auxpass are,detected
R5084 T20921 T20916 advmod strongly,detected
R5085 T20922 T20916 prep around,detected
R5086 T20923 T20922 pobj P6,around
R5087 T20924 T20899 punct .,are
R5088 T20926 T20927 advmod Therefore,suggest
R5089 T20928 T20927 punct ", ",suggest
R5090 T20929 T20930 poss our,results
R5091 T20930 T20927 nsubj results,suggest
R5092 T20931 T20927 advmod strongly,suggest
R5093 T20932 T20933 mark that,regulated
R5094 T20933 T20927 ccomp regulated,suggest
R5095 T20934 T20935 compound mr,s
R5096 T20935 T20937 compound s,transcription
R5097 T20936 T20935 punct -,s
R5098 T20937 T20933 nsubjpass transcription,regulated
R5099 T20938 T20933 auxpass is,regulated
R5100 T20939 T20933 advmod directly,regulated
R5101 T20940 T20933 agent by,regulated
R5102 T20941 T20940 pobj Crx,by
R5103 T20942 T20927 punct .,suggest
R5104 T20944 T20945 prep In,affect
R5105 T20946 T20947 det the,study
R5106 T20947 T20944 pobj study,In
R5107 T20948 T20947 amod present,study
R5108 T20949 T20945 punct ", ",affect
R5109 T20950 T20945 nsubj Nrl,affect
R5110 T20951 T20950 punct ", ",Nrl
R5111 T20952 T20953 det a,factor
R5112 T20953 T20950 appos factor,Nrl
R5113 T20954 T20955 npadvmod photoreceptor,specific
R5114 T20955 T20953 amod specific,factor
R5115 T20956 T20955 punct -,specific
R5116 T20957 T20953 compound transcription,factor
R5117 T20958 T20959 dep that,expressed
R5118 T20959 T20953 relcl expressed,factor
R5119 T20960 T20959 auxpass is,expressed
R5120 T20961 T20959 advmod highly,expressed
R5121 T20962 T20959 prep in,expressed
R5122 T20963 T20962 pobj photoreceptors,in
R5123 T20964 T20959 prep at,expressed
R5124 T20965 T20966 det the,stage
R5125 T20966 T20964 pobj stage,at
R5126 T20967 T20966 amod postnatal,stage
R5127 T20968 T20945 punct ", ",affect
R5128 T20969 T20945 aux did,affect
R5129 T20970 T20945 neg not,affect
R5130 T20971 T20972 det the,transcription
R5131 T20972 T20945 dobj transcription,affect
R5132 T20973 T20972 prep of,transcription
R5133 T20974 T20975 compound mr,s
R5134 T20975 T20973 pobj s,of
R5135 T20976 T20975 punct -,s
R5136 T20977 T20945 punct .,affect
R5137 T20979 T20980 det This,finding
R5138 T20980 T20981 nsubj finding,is
R5139 T20982 T20981 advmod actually,is
R5140 T20983 T20981 acomp consistent,is
R5141 T20984 T20983 prep with,consistent
R5142 T20985 T20986 det the,analysis
R5143 T20986 T20984 pobj analysis,with
R5144 T20987 T20986 prep of,analysis
R5145 T20988 T20989 det the,mouse
R5146 T20989 T20987 pobj mouse,of
R5147 T20990 T20991 compound Nrl,KO
R5148 T20991 T20989 compound KO,mouse
R5149 T20992 T20993 dep which,reported
R5150 T20993 T20989 relcl reported,mouse
R5151 T20994 T20993 auxpass was,reported
R5152 T20995 T20993 advmod recently,reported
R5153 T20996 T20997 punct [,40
R5154 T20997 T20981 parataxis 40,is
R5155 T20998 T20997 punct ],40
R5156 T20999 T20981 punct .,is
R5157 T21001 T21002 det The,profiles
R5158 T21002 T21004 nsubjpass profiles,analyzed
R5159 T21003 T21002 compound expression,profiles
R5160 T21005 T21002 prep of,profiles
R5161 T21006 T21007 amod wild,type
R5162 T21007 T21009 nmod type,retinas
R5163 T21008 T21007 punct -,type
R5164 T21009 T21005 pobj retinas,of
R5165 T21010 T21007 cc and,type
R5166 T21011 T21012 compound Nrl,KO
R5167 T21012 T21007 conj KO,type
R5168 T21013 T21002 prep at,profiles
R5169 T21014 T21013 pobj P2,at
R5170 T21015 T21014 punct ", ",P2
R5171 T21016 T21014 conj P10,P2
R5172 T21017 T21016 cc and,P10
R5173 T21018 T21019 nummod 2,months
R5174 T21019 T21016 conj months,P10
R5175 T21020 T21004 auxpass were,analyzed
R5176 T21021 T21004 cc and,analyzed
R5177 T21022 T21023 compound mr,s
R5178 T21023 T21025 nsubjpass s,included
R5179 T21024 T21023 punct -,s
R5180 T21025 T21004 conj included,analyzed
R5181 T21026 T21025 auxpass was,included
R5182 T21027 T21025 neg not,included
R5183 T21028 T21025 prep in,included
R5184 T21029 T21030 nummod 161,genes
R5185 T21030 T21028 pobj genes,in
R5186 T21031 T21032 advmod differentially,expressed
R5187 T21032 T21030 amod expressed,genes
R5188 T21033 T21025 prep in,included
R5189 T21034 T21035 det the,retina
R5190 T21035 T21033 pobj retina,in
R5191 T21036 T21037 compound Nrl,KO
R5192 T21037 T21035 compound KO,retina
R5193 T21038 T21025 punct .,included