Id |
Subject |
Object |
Predicate |
Lexical cue |
T9954 |
0-1 |
DT |
denotes |
T |
T9953 |
0-6 |
sentence |
denotes |
To fur |
T9955 |
1-2 |
NN |
denotes |
o |
T9957 |
3-4 |
IN |
denotes |
f |
T9956 |
4-5 |
VBN |
denotes |
u |
T9958 |
5-6 |
NN |
denotes |
r |
T9960 |
6-7 |
FW |
denotes |
t |
T9959 |
6-14 |
sentence |
denotes |
ther exa |
T9961 |
7-8 |
NN |
denotes |
h |
T9962 |
8-9 |
NN |
denotes |
e |
T9963 |
9-10 |
IN |
denotes |
r |
T9964 |
11-12 |
NN |
denotes |
e |
T9966 |
12-13 |
NN |
denotes |
x |
T9965 |
13-14 |
NNS |
denotes |
a |
T9968 |
14-15 |
NN |
denotes |
m |
T9967 |
14-19 |
sentence |
denotes |
mine |
T9969 |
15-17 |
NN |
denotes |
in |
T9970 |
17-18 |
VBN |
denotes |
e |
T9971 |
19-20 |
sentence |
denotes |
w |
T9972 |
19-20 |
JJ |
denotes |
w |
T9974 |
20-22 |
DT |
denotes |
he |
T9973 |
20-27 |
sentence |
denotes |
hether |
T9975 |
22-23 |
NNS |
denotes |
t |
T9976 |
23-25 |
DT |
denotes |
he |
T9977 |
25-26 |
NN |
denotes |
r |
T9980 |
27-28 |
NN |
denotes |
C |
T9978 |
27-29 |
sentence |
denotes |
Cr |
T9979 |
28-29 |
NN |
denotes |
r |
T9983 |
29-30 |
NN |
denotes |
x |
T9981 |
29-33 |
sentence |
denotes |
x re |
T9982 |
31-33 |
VBZ |
denotes |
re |
T9984 |
33-34 |
sentence |
denotes |
g |
T9985 |
33-34 |
NN |
denotes |
g |
T9987 |
34-35 |
NN |
denotes |
u |
T9986 |
34-39 |
sentence |
denotes |
ulate |
T9988 |
35-36 |
NN |
denotes |
l |
T9989 |
36-37 |
CC |
denotes |
a |
T9990 |
37-39 |
RB |
denotes |
te |
T9992 |
39-40 |
VBZ |
denotes |
s |
T9991 |
39-48 |
sentence |
denotes |
s mr-s tr |
T9994 |
41-42 |
NN |
denotes |
m |
T9995 |
42-43 |
VBD |
denotes |
r |
T9993 |
43-45 |
VBN |
denotes |
-s |
T9996 |
46-47 |
IN |
denotes |
t |
T9997 |
47-48 |
NN |
denotes |
r |
T9999 |
48-49 |
NNS |
denotes |
a |
T9998 |
48-51 |
sentence |
denotes |
ans |
T10000 |
49-50 |
VBP |
denotes |
n |
T10001 |
50-51 |
JJ |
denotes |
s |
T10004 |
51-59 |
NN |
denotes |
cription |
T10002 |
51-291 |
sentence |
denotes |
cription directly or not, we next performed a luciferase assay using the 1.2-kb proximal promoter region of mr-s fused to a luciferase gene as a luciferase reporter (Fig. 3D, Pro1.2k) and the Crx, Otx2, Nrl expression vectors, respectively. |
T10005 |
60-68 |
RB |
denotes |
directly |
T10006 |
69-71 |
CC |
denotes |
or |
T10007 |
72-75 |
RB |
denotes |
not |
T10008 |
75-77 |
, |
denotes |
, |
T10009 |
77-79 |
PRP |
denotes |
we |
T10010 |
80-84 |
RB |
denotes |
next |
T10003 |
85-94 |
VBD |
denotes |
performed |
T10011 |
95-96 |
DT |
denotes |
a |
T10013 |
97-107 |
NN |
denotes |
luciferase |
T10012 |
108-113 |
NN |
denotes |
assay |
T10014 |
114-119 |
VBG |
denotes |
using |
T10015 |
120-123 |
DT |
denotes |
the |
T10017 |
124-127 |
CD |
denotes |
1.2 |
T10019 |
127-128 |
HYPH |
denotes |
- |
T10018 |
128-130 |
NN |
denotes |
kb |
T10020 |
131-139 |
JJ |
denotes |
proximal |
T10021 |
140-148 |
NN |
denotes |
promoter |
T10016 |
149-155 |
NN |
denotes |
region |
T10022 |
156-158 |
IN |
denotes |
of |
T10023 |
159-161 |
NN |
denotes |
mr |
T10025 |
161-162 |
HYPH |
denotes |
- |
T10024 |
162-163 |
NN |
denotes |
s |
T10026 |
164-169 |
VBN |
denotes |
fused |
T10027 |
170-172 |
IN |
denotes |
to |
T10028 |
173-174 |
DT |
denotes |
a |
T10030 |
175-185 |
NN |
denotes |
luciferase |
T10029 |
186-190 |
NN |
denotes |
gene |
T10031 |
191-193 |
IN |
denotes |
as |
T10032 |
194-195 |
DT |
denotes |
a |
T10034 |
196-206 |
NN |
denotes |
luciferase |
T10033 |
207-215 |
NN |
denotes |
reporter |
T10035 |
216-217 |
-LRB- |
denotes |
( |
T10037 |
217-221 |
NN |
denotes |
Fig. |
T10036 |
222-224 |
NN |
denotes |
3D |
T10038 |
224-226 |
, |
denotes |
, |
T10039 |
226-233 |
NN |
denotes |
Pro1.2k |
T10040 |
233-234 |
-RRB- |
denotes |
) |
T10041 |
235-238 |
CC |
denotes |
and |
T10042 |
239-242 |
DT |
denotes |
the |
T10044 |
243-246 |
NN |
denotes |
Crx |
T10046 |
246-248 |
, |
denotes |
, |
T10047 |
248-252 |
NN |
denotes |
Otx2 |
T10048 |
252-254 |
, |
denotes |
, |
T10045 |
254-257 |
NN |
denotes |
Nrl |
T10049 |
258-268 |
NN |
denotes |
expression |
T10043 |
269-276 |
NNS |
denotes |
vectors |
T10050 |
276-278 |
, |
denotes |
, |
T10051 |
278-290 |
RB |
denotes |
respectively |
T10052 |
290-291 |
. |
denotes |
. |
T10053 |
291-388 |
sentence |
denotes |
This 1.2-kb region of the mr-s upstream sequence contains three Crx binding consensus sequences. |
T10054 |
292-296 |
DT |
denotes |
This |
T10056 |
297-300 |
CD |
denotes |
1.2 |
T10058 |
300-301 |
HYPH |
denotes |
- |
T10057 |
301-303 |
NN |
denotes |
kb |
T10055 |
304-310 |
NN |
denotes |
region |
T10060 |
311-313 |
IN |
denotes |
of |
T10061 |
314-317 |
DT |
denotes |
the |
T10063 |
318-320 |
NN |
denotes |
mr |
T10065 |
320-321 |
HYPH |
denotes |
- |
T10064 |
321-322 |
NN |
denotes |
s |
T10066 |
323-331 |
JJ |
denotes |
upstream |
T10062 |
332-340 |
NN |
denotes |
sequence |
T10059 |
341-349 |
VBZ |
denotes |
contains |
T10067 |
350-355 |
CD |
denotes |
three |
T10069 |
356-359 |
NN |
denotes |
Crx |
T10070 |
360-367 |
NN |
denotes |
binding |
T10071 |
368-377 |
NN |
denotes |
consensus |
T10068 |
378-387 |
NNS |
denotes |
sequences |
T10072 |
387-388 |
. |
denotes |
. |
T10073 |
388-649 |
sentence |
denotes |
As shown in Fig. 3E, the luciferase activity was significantly upregulated when the Crx or Otx2 expression vector was co-introduced with Pro1.2k into HEK293T cells, while the luciferase activity was not altered when the Nrl expression vector was co-introduced. |
T10074 |
389-391 |
IN |
denotes |
As |
T10075 |
392-397 |
VBN |
denotes |
shown |
T10077 |
398-400 |
IN |
denotes |
in |
T10078 |
401-405 |
NN |
denotes |
Fig. |
T10079 |
406-408 |
NN |
denotes |
3E |
T10080 |
408-410 |
, |
denotes |
, |
T10081 |
410-413 |
DT |
denotes |
the |
T10083 |
414-424 |
NN |
denotes |
luciferase |
T10082 |
425-433 |
NN |
denotes |
activity |
T10084 |
434-437 |
VBD |
denotes |
was |
T10085 |
438-451 |
RB |
denotes |
significantly |
T10076 |
452-463 |
VBN |
denotes |
upregulated |
T10086 |
464-468 |
WRB |
denotes |
when |
T10088 |
469-472 |
DT |
denotes |
the |
T10090 |
473-476 |
NN |
denotes |
Crx |
T10091 |
477-479 |
CC |
denotes |
or |
T10092 |
480-484 |
NN |
denotes |
Otx2 |
T10093 |
485-495 |
NN |
denotes |
expression |
T10089 |
496-502 |
NN |
denotes |
vector |
T10094 |
503-506 |
VBD |
denotes |
was |
T10087 |
507-520 |
VBN |
denotes |
co-introduced |
T10095 |
521-525 |
IN |
denotes |
with |
T10096 |
526-533 |
NN |
denotes |
Pro1.2k |
T10097 |
534-538 |
IN |
denotes |
into |
T10098 |
539-546 |
NN |
denotes |
HEK293T |
T10099 |
547-552 |
NNS |
denotes |
cells |
T10100 |
552-554 |
, |
denotes |
, |
T10101 |
554-559 |
IN |
denotes |
while |
T10103 |
560-563 |
DT |
denotes |
the |
T10105 |
564-574 |
NN |
denotes |
luciferase |
T10104 |
575-583 |
NN |
denotes |
activity |
T10106 |
584-587 |
VBD |
denotes |
was |
T10107 |
588-591 |
RB |
denotes |
not |
T10102 |
592-599 |
VBN |
denotes |
altered |
T10108 |
600-604 |
WRB |
denotes |
when |
T10110 |
605-608 |
DT |
denotes |
the |
T10112 |
609-612 |
NN |
denotes |
Nrl |
T10113 |
613-623 |
NN |
denotes |
expression |
T10111 |
624-630 |
NN |
denotes |
vector |
T10114 |
631-634 |
VBD |
denotes |
was |
T10109 |
635-648 |
VBN |
denotes |
co-introduced |
T10115 |
648-649 |
. |
denotes |
. |
T10116 |
649-801 |
sentence |
denotes |
A previous report suggested that the transcriptional activity of Crx is augmented with Nrl when the rhodopsin promoter was used as a reporter gene [6]. |
T10117 |
650-651 |
DT |
denotes |
A |
T10119 |
652-660 |
JJ |
denotes |
previous |
T10118 |
661-667 |
NN |
denotes |
report |
T10120 |
668-677 |
VBD |
denotes |
suggested |
T10121 |
678-682 |
IN |
denotes |
that |
T10123 |
683-686 |
DT |
denotes |
the |
T10125 |
687-702 |
JJ |
denotes |
transcriptional |
T10124 |
703-711 |
NN |
denotes |
activity |
T10126 |
712-714 |
IN |
denotes |
of |
T10127 |
715-718 |
NN |
denotes |
Crx |
T10128 |
719-721 |
VBZ |
denotes |
is |
T10122 |
722-731 |
VBN |
denotes |
augmented |
T10129 |
732-736 |
IN |
denotes |
with |
T10130 |
737-740 |
NN |
denotes |
Nrl |
T10131 |
741-745 |
WRB |
denotes |
when |
T10133 |
746-749 |
DT |
denotes |
the |
T10135 |
750-759 |
NN |
denotes |
rhodopsin |
T10134 |
760-768 |
NN |
denotes |
promoter |
T10136 |
769-772 |
VBD |
denotes |
was |
T10132 |
773-777 |
VBN |
denotes |
used |
T10137 |
778-780 |
IN |
denotes |
as |
T10138 |
781-782 |
DT |
denotes |
a |
T10140 |
783-791 |
NN |
denotes |
reporter |
T10139 |
792-796 |
NN |
denotes |
gene |
T10141 |
797-798 |
-LRB- |
denotes |
[ |
T10142 |
798-799 |
CD |
denotes |
6 |
T10143 |
799-800 |
-RRB- |
denotes |
] |
T10144 |
800-801 |
. |
denotes |
. |
T10145 |
801-1050 |
sentence |
denotes |
On the other hand, our present data showed that the luciferase gene expression was not upregulated when both Crx and Nrl expression vectors were co-introduced with Pro1.2k compared to the activity when the Crx only expression vector was introduced. |
T10146 |
802-804 |
IN |
denotes |
On |
T10148 |
805-808 |
DT |
denotes |
the |
T10150 |
809-814 |
JJ |
denotes |
other |
T10149 |
815-819 |
NN |
denotes |
hand |
T10151 |
819-821 |
, |
denotes |
, |
T10152 |
821-824 |
PRP$ |
denotes |
our |
T10154 |
825-832 |
JJ |
denotes |
present |
T10153 |
833-837 |
NNS |
denotes |
data |
T10147 |
838-844 |
VBD |
denotes |
showed |
T10155 |
845-849 |
IN |
denotes |
that |
T10157 |
850-853 |
DT |
denotes |
the |
T10159 |
854-864 |
NN |
denotes |
luciferase |
T10160 |
865-869 |
NN |
denotes |
gene |
T10158 |
870-880 |
NN |
denotes |
expression |
T10161 |
881-884 |
VBD |
denotes |
was |
T10162 |
885-888 |
RB |
denotes |
not |
T10156 |
889-900 |
VBN |
denotes |
upregulated |
T10163 |
901-905 |
WRB |
denotes |
when |
T10165 |
906-910 |
CC |
denotes |
both |
T10166 |
911-914 |
NN |
denotes |
Crx |
T10168 |
915-918 |
CC |
denotes |
and |
T10169 |
919-922 |
NN |
denotes |
Nrl |
T10170 |
923-933 |
NN |
denotes |
expression |
T10167 |
934-941 |
NNS |
denotes |
vectors |
T10171 |
942-946 |
VBD |
denotes |
were |
T10164 |
947-960 |
VBN |
denotes |
co-introduced |
T10172 |
961-965 |
IN |
denotes |
with |
T10173 |
966-973 |
NN |
denotes |
Pro1.2k |
T10174 |
974-982 |
VBN |
denotes |
compared |
T10175 |
983-985 |
IN |
denotes |
to |
T10176 |
986-989 |
DT |
denotes |
the |
T10177 |
990-998 |
NN |
denotes |
activity |
T10178 |
999-1003 |
WRB |
denotes |
when |
T10180 |
1004-1007 |
DT |
denotes |
the |
T10182 |
1008-1011 |
NN |
denotes |
Crx |
T10183 |
1012-1016 |
JJ |
denotes |
only |
T10184 |
1017-1027 |
NN |
denotes |
expression |
T10181 |
1028-1034 |
NN |
denotes |
vector |
T10185 |
1035-1038 |
VBD |
denotes |
was |
T10179 |
1039-1049 |
VBN |
denotes |
introduced |
T10186 |
1049-1050 |
. |
denotes |
. |
T10187 |
1050-1174 |
sentence |
denotes |
This may be due to cell type differences because a cell type of retinal/pineal origin was not used in our luciferase assay. |
T10188 |
1051-1055 |
DT |
denotes |
This |
T10190 |
1056-1059 |
MD |
denotes |
may |
T10189 |
1060-1062 |
VB |
denotes |
be |
T10191 |
1063-1066 |
IN |
denotes |
due |
T10192 |
1067-1069 |
IN |
denotes |
to |
T10193 |
1070-1074 |
NN |
denotes |
cell |
T10194 |
1075-1079 |
NN |
denotes |
type |
T10195 |
1080-1091 |
NNS |
denotes |
differences |
T10196 |
1092-1099 |
IN |
denotes |
because |
T10198 |
1100-1101 |
DT |
denotes |
a |
T10200 |
1102-1106 |
NN |
denotes |
cell |
T10199 |
1107-1111 |
NN |
denotes |
type |
T10201 |
1112-1114 |
IN |
denotes |
of |
T10202 |
1115-1122 |
JJ |
denotes |
retinal |
T10204 |
1122-1123 |
HYPH |
denotes |
/ |
T10203 |
1123-1129 |
JJ |
denotes |
pineal |
T10205 |
1130-1136 |
NN |
denotes |
origin |
T10206 |
1137-1140 |
VBD |
denotes |
was |
T10207 |
1141-1144 |
RB |
denotes |
not |
T10197 |
1145-1149 |
VBN |
denotes |
used |
T10208 |
1150-1152 |
IN |
denotes |
in |
T10209 |
1153-1156 |
PRP$ |
denotes |
our |
T10211 |
1157-1167 |
NN |
denotes |
luciferase |
T10210 |
1168-1173 |
NN |
denotes |
assay |
T10212 |
1173-1174 |
. |
denotes |
. |
T10213 |
1174-1320 |
sentence |
denotes |
In addition, our present data showed that Otx2, which is reported to have the same binding consensus as Crx, also transactivated mr-s expression. |
T10214 |
1175-1177 |
IN |
denotes |
In |
T10216 |
1178-1186 |
NN |
denotes |
addition |
T10217 |
1186-1188 |
, |
denotes |
, |
T10218 |
1188-1191 |
PRP$ |
denotes |
our |
T10220 |
1192-1199 |
JJ |
denotes |
present |
T10219 |
1200-1204 |
NNS |
denotes |
data |
T10215 |
1205-1211 |
VBD |
denotes |
showed |
T10221 |
1212-1216 |
IN |
denotes |
that |
T10223 |
1217-1221 |
NN |
denotes |
Otx2 |
T10224 |
1221-1223 |
, |
denotes |
, |
T10225 |
1223-1228 |
WDT |
denotes |
which |
T10227 |
1229-1231 |
VBZ |
denotes |
is |
T10226 |
1232-1240 |
VBN |
denotes |
reported |
T10228 |
1241-1243 |
TO |
denotes |
to |
T10229 |
1244-1248 |
VB |
denotes |
have |
T10230 |
1249-1252 |
DT |
denotes |
the |
T10232 |
1253-1257 |
JJ |
denotes |
same |
T10233 |
1258-1265 |
NN |
denotes |
binding |
T10231 |
1266-1275 |
NN |
denotes |
consensus |
T10234 |
1276-1278 |
IN |
denotes |
as |
T10235 |
1279-1282 |
NN |
denotes |
Crx |
T10236 |
1282-1284 |
, |
denotes |
, |
T10237 |
1284-1288 |
RB |
denotes |
also |
T10222 |
1289-1303 |
VBN |
denotes |
transactivated |
T10238 |
1304-1306 |
NN |
denotes |
mr |
T10240 |
1306-1307 |
HYPH |
denotes |
- |
T10239 |
1307-1308 |
NN |
denotes |
s |
T10241 |
1309-1319 |
NN |
denotes |
expression |
T10242 |
1319-1320 |
. |
denotes |
. |
T10243 |
1320-1403 |
sentence |
denotes |
As shown in Fig. 2A–F, the expression pattern of mr-s correlates with that of Crx. |
T10244 |
1321-1323 |
IN |
denotes |
As |
T10245 |
1324-1329 |
VBN |
denotes |
shown |
T10247 |
1330-1332 |
IN |
denotes |
in |
T10248 |
1333-1337 |
NN |
denotes |
Fig. |
T10249 |
1338-1340 |
NN |
denotes |
2A |
T10250 |
1340-1341 |
SYM |
denotes |
– |
T10251 |
1341-1342 |
NN |
denotes |
F |
T10252 |
1342-1344 |
, |
denotes |
, |
T10253 |
1344-1347 |
DT |
denotes |
the |
T10255 |
1348-1358 |
NN |
denotes |
expression |
T10254 |
1359-1366 |
NN |
denotes |
pattern |
T10256 |
1367-1369 |
IN |
denotes |
of |
T10257 |
1370-1372 |
NN |
denotes |
mr |
T10259 |
1372-1373 |
HYPH |
denotes |
- |
T10258 |
1373-1374 |
NN |
denotes |
s |
T10246 |
1375-1385 |
VBZ |
denotes |
correlates |
T10260 |
1386-1390 |
IN |
denotes |
with |
T10261 |
1391-1395 |
DT |
denotes |
that |
T10262 |
1396-1398 |
IN |
denotes |
of |
T10263 |
1399-1402 |
NN |
denotes |
Crx |
T10264 |
1402-1403 |
. |
denotes |
. |
T10265 |
1403-1508 |
sentence |
denotes |
In contrast, the transcripts of Otx2 are mainly detected in the photoreceptor layer at embryonic stages. |
T10266 |
1404-1406 |
IN |
denotes |
In |
T10268 |
1407-1415 |
NN |
denotes |
contrast |
T10269 |
1415-1417 |
, |
denotes |
, |
T10270 |
1417-1420 |
DT |
denotes |
the |
T10271 |
1421-1432 |
NNS |
denotes |
transcripts |
T10272 |
1433-1435 |
IN |
denotes |
of |
T10273 |
1436-1440 |
NN |
denotes |
Otx2 |
T10274 |
1441-1444 |
VBP |
denotes |
are |
T10275 |
1445-1451 |
RB |
denotes |
mainly |
T10267 |
1452-1460 |
VBN |
denotes |
detected |
T10276 |
1461-1463 |
IN |
denotes |
in |
T10277 |
1464-1467 |
DT |
denotes |
the |
T10279 |
1468-1481 |
NN |
denotes |
photoreceptor |
T10278 |
1482-1487 |
NN |
denotes |
layer |
T10280 |
1488-1490 |
IN |
denotes |
at |
T10281 |
1491-1500 |
JJ |
denotes |
embryonic |
T10282 |
1501-1507 |
NNS |
denotes |
stages |
T10283 |
1507-1508 |
. |
denotes |
. |
T10284 |
1508-1593 |
sentence |
denotes |
Therefore, we concluded that mr-s transcription is directly regulated mainly by Crx. |
T10285 |
1509-1518 |
RB |
denotes |
Therefore |
T10287 |
1518-1520 |
, |
denotes |
, |
T10288 |
1520-1522 |
PRP |
denotes |
we |
T10286 |
1523-1532 |
VBD |
denotes |
concluded |
T10289 |
1533-1537 |
IN |
denotes |
that |
T10291 |
1538-1540 |
NN |
denotes |
mr |
T10293 |
1540-1541 |
HYPH |
denotes |
- |
T10292 |
1541-1542 |
NN |
denotes |
s |
T10294 |
1543-1556 |
NN |
denotes |
transcription |
T10295 |
1557-1559 |
VBZ |
denotes |
is |
T10296 |
1560-1568 |
RB |
denotes |
directly |
T10290 |
1569-1578 |
VBN |
denotes |
regulated |
T10297 |
1579-1585 |
RB |
denotes |
mainly |
T10298 |
1586-1588 |
IN |
denotes |
by |
T10299 |
1589-1592 |
NN |
denotes |
Crx |
T10300 |
1592-1593 |
. |
denotes |
. |
R2463 |
T9954 |
T9955 |
det |
T,o |
R2464 |
T9955 |
T9956 |
nsubjpass |
o,u |
R2465 |
T9957 |
T9955 |
prep |
f,o |
R2466 |
T9960 |
T9961 |
amod |
t,h |
R2467 |
T9963 |
T9962 |
prep |
r,e |
R2468 |
T9969 |
T9970 |
nsubjpass |
in,e |
R2469 |
T9980 |
T9979 |
compound |
C,r |
R2470 |
T9983 |
T9982 |
nsubj |
x,re |
R2471 |
T9989 |
T9988 |
cc |
a,l |
R2472 |
T9995 |
T9993 |
auxpass |
r,-s |
R2473 |
T9996 |
T9993 |
prep |
t,-s |
R2474 |
T9999 |
T10000 |
nsubj |
a,n |
R2475 |
T10008 |
T10003 |
punct |
", ",performed |
R2476 |
T10009 |
T10003 |
nsubj |
we,performed |
R2477 |
T10010 |
T10003 |
advmod |
next,performed |
R2478 |
T10011 |
T10012 |
det |
a,assay |
R2479 |
T10012 |
T10003 |
dobj |
assay,performed |
R2480 |
T10013 |
T10012 |
compound |
luciferase,assay |
R2481 |
T10014 |
T10003 |
advcl |
using,performed |
R2482 |
T10015 |
T10016 |
det |
the,region |
R2483 |
T10016 |
T10014 |
dobj |
region,using |
R2484 |
T10017 |
T10018 |
nummod |
1.2,kb |
R2485 |
T10018 |
T10016 |
nmod |
kb,region |
R2486 |
T10019 |
T10018 |
punct |
-,kb |
R2487 |
T10020 |
T10016 |
amod |
proximal,region |
R2488 |
T10021 |
T10016 |
compound |
promoter,region |
R2489 |
T10022 |
T10016 |
prep |
of,region |
R2490 |
T10023 |
T10024 |
compound |
mr,s |
R2491 |
T10024 |
T10022 |
pobj |
s,of |
R2492 |
T10025 |
T10024 |
punct |
-,s |
R2493 |
T10026 |
T10016 |
acl |
fused,region |
R2494 |
T10027 |
T10026 |
prep |
to,fused |
R2495 |
T10028 |
T10029 |
det |
a,gene |
R2496 |
T10029 |
T10027 |
pobj |
gene,to |
R2497 |
T10030 |
T10029 |
compound |
luciferase,gene |
R2498 |
T10031 |
T10029 |
prep |
as,gene |
R2499 |
T10032 |
T10033 |
det |
a,reporter |
R2500 |
T10033 |
T10031 |
pobj |
reporter,as |
R2501 |
T10034 |
T10033 |
compound |
luciferase,reporter |
R2502 |
T10035 |
T10036 |
punct |
(,3D |
R2503 |
T10036 |
T10033 |
parataxis |
3D,reporter |
R2504 |
T10037 |
T10036 |
compound |
Fig.,3D |
R2505 |
T10038 |
T10036 |
punct |
", ",3D |
R2506 |
T10039 |
T10036 |
appos |
Pro1.2k,3D |
R2507 |
T10040 |
T10036 |
punct |
),3D |
R2508 |
T10041 |
T10029 |
cc |
and,gene |
R2509 |
T10042 |
T10043 |
det |
the,vectors |
R2510 |
T10043 |
T10029 |
conj |
vectors,gene |
R2511 |
T10044 |
T10045 |
nmod |
Crx,Nrl |
R2512 |
T10045 |
T10043 |
compound |
Nrl,vectors |
R2513 |
T10046 |
T10045 |
punct |
", ",Nrl |
R2514 |
T10047 |
T10045 |
nmod |
Otx2,Nrl |
R2515 |
T10048 |
T10045 |
punct |
", ",Nrl |
R2516 |
T10049 |
T10043 |
compound |
expression,vectors |
R2517 |
T10050 |
T10026 |
punct |
", ",fused |
R2518 |
T10051 |
T10026 |
advmod |
respectively,fused |
R2519 |
T10052 |
T10003 |
punct |
.,performed |
R2520 |
T10054 |
T10055 |
det |
This,region |
R2521 |
T10055 |
T10059 |
nsubj |
region,contains |
R2522 |
T10056 |
T10057 |
nummod |
1.2,kb |
R2523 |
T10057 |
T10055 |
compound |
kb,region |
R2524 |
T10058 |
T10057 |
punct |
-,kb |
R2525 |
T10060 |
T10055 |
prep |
of,region |
R2526 |
T10061 |
T10062 |
det |
the,sequence |
R2527 |
T10062 |
T10060 |
pobj |
sequence,of |
R2528 |
T10063 |
T10064 |
nmod |
mr,s |
R2529 |
T10064 |
T10062 |
nmod |
s,sequence |
R2530 |
T10065 |
T10064 |
punct |
-,s |
R2531 |
T10066 |
T10062 |
amod |
upstream,sequence |
R2532 |
T10067 |
T10068 |
nummod |
three,sequences |
R2533 |
T10068 |
T10059 |
dobj |
sequences,contains |
R2534 |
T10069 |
T10070 |
compound |
Crx,binding |
R2535 |
T10070 |
T10068 |
compound |
binding,sequences |
R2536 |
T10071 |
T10068 |
compound |
consensus,sequences |
R2537 |
T10072 |
T10059 |
punct |
.,contains |
R2538 |
T10074 |
T10075 |
mark |
As,shown |
R2539 |
T10075 |
T10076 |
advcl |
shown,upregulated |
R2540 |
T10077 |
T10075 |
prep |
in,shown |
R2541 |
T10078 |
T10079 |
compound |
Fig.,3E |
R2542 |
T10079 |
T10077 |
pobj |
3E,in |
R2543 |
T10080 |
T10076 |
punct |
", ",upregulated |
R2544 |
T10081 |
T10082 |
det |
the,activity |
R2545 |
T10082 |
T10076 |
nsubjpass |
activity,upregulated |
R2546 |
T10083 |
T10082 |
compound |
luciferase,activity |
R2547 |
T10084 |
T10076 |
auxpass |
was,upregulated |
R2548 |
T10085 |
T10076 |
advmod |
significantly,upregulated |
R2549 |
T10086 |
T10087 |
advmod |
when,co-introduced |
R2550 |
T10087 |
T10076 |
advcl |
co-introduced,upregulated |
R2551 |
T10088 |
T10089 |
det |
the,vector |
R2552 |
T10089 |
T10087 |
nsubjpass |
vector,co-introduced |
R2553 |
T10090 |
T10089 |
nmod |
Crx,vector |
R2554 |
T10091 |
T10090 |
cc |
or,Crx |
R2555 |
T10092 |
T10090 |
conj |
Otx2,Crx |
R2556 |
T10093 |
T10089 |
compound |
expression,vector |
R2557 |
T10094 |
T10087 |
auxpass |
was,co-introduced |
R2558 |
T10095 |
T10087 |
prep |
with,co-introduced |
R2559 |
T10096 |
T10095 |
pobj |
Pro1.2k,with |
R2560 |
T10097 |
T10087 |
prep |
into,co-introduced |
R2561 |
T10098 |
T10099 |
compound |
HEK293T,cells |
R2562 |
T10099 |
T10097 |
pobj |
cells,into |
R2563 |
T10100 |
T10087 |
punct |
", ",co-introduced |
R2564 |
T10101 |
T10102 |
mark |
while,altered |
R2565 |
T10102 |
T10087 |
advcl |
altered,co-introduced |
R2566 |
T10103 |
T10104 |
det |
the,activity |
R2567 |
T10104 |
T10102 |
nsubjpass |
activity,altered |
R2568 |
T10105 |
T10104 |
compound |
luciferase,activity |
R2569 |
T10106 |
T10102 |
auxpass |
was,altered |
R2570 |
T10107 |
T10102 |
neg |
not,altered |
R2571 |
T10108 |
T10109 |
advmod |
when,co-introduced |
R2572 |
T10109 |
T10102 |
advcl |
co-introduced,altered |
R2573 |
T10110 |
T10111 |
det |
the,vector |
R2574 |
T10111 |
T10109 |
nsubjpass |
vector,co-introduced |
R2575 |
T10112 |
T10111 |
compound |
Nrl,vector |
R2576 |
T10113 |
T10111 |
compound |
expression,vector |
R2577 |
T10114 |
T10109 |
auxpass |
was,co-introduced |
R2578 |
T10115 |
T10076 |
punct |
.,upregulated |
R2579 |
T10117 |
T10118 |
det |
A,report |
R2580 |
T10118 |
T10120 |
nsubj |
report,suggested |
R2581 |
T10119 |
T10118 |
amod |
previous,report |
R2582 |
T10121 |
T10122 |
mark |
that,augmented |
R2583 |
T10122 |
T10120 |
ccomp |
augmented,suggested |
R2584 |
T10123 |
T10124 |
det |
the,activity |
R2585 |
T10124 |
T10122 |
nsubjpass |
activity,augmented |
R2586 |
T10125 |
T10124 |
amod |
transcriptional,activity |
R2587 |
T10126 |
T10124 |
prep |
of,activity |
R2588 |
T10127 |
T10126 |
pobj |
Crx,of |
R2589 |
T10128 |
T10122 |
auxpass |
is,augmented |
R2590 |
T10129 |
T10122 |
prep |
with,augmented |
R2591 |
T10130 |
T10129 |
pobj |
Nrl,with |
R2592 |
T10131 |
T10132 |
advmod |
when,used |
R2593 |
T10132 |
T10122 |
advcl |
used,augmented |
R2594 |
T10133 |
T10134 |
det |
the,promoter |
R2595 |
T10134 |
T10132 |
nsubjpass |
promoter,used |
R2596 |
T10135 |
T10134 |
compound |
rhodopsin,promoter |
R2597 |
T10136 |
T10132 |
auxpass |
was,used |
R2598 |
T10137 |
T10132 |
prep |
as,used |
R2599 |
T10138 |
T10139 |
det |
a,gene |
R2600 |
T10139 |
T10137 |
pobj |
gene,as |
R2601 |
T10140 |
T10139 |
compound |
reporter,gene |
R2602 |
T10141 |
T10142 |
punct |
[,6 |
R2603 |
T10142 |
T10120 |
parataxis |
6,suggested |
R2604 |
T10143 |
T10142 |
punct |
],6 |
R2605 |
T10144 |
T10120 |
punct |
.,suggested |
R2606 |
T10146 |
T10147 |
prep |
On,showed |
R2607 |
T10148 |
T10149 |
det |
the,hand |
R2608 |
T10149 |
T10146 |
pobj |
hand,On |
R2609 |
T10150 |
T10149 |
amod |
other,hand |
R2610 |
T10151 |
T10147 |
punct |
", ",showed |
R2611 |
T10152 |
T10153 |
poss |
our,data |
R2612 |
T10153 |
T10147 |
nsubj |
data,showed |
R2613 |
T10154 |
T10153 |
amod |
present,data |
R2614 |
T10155 |
T10156 |
mark |
that,upregulated |
R2615 |
T10156 |
T10147 |
ccomp |
upregulated,showed |
R2616 |
T10157 |
T10158 |
det |
the,expression |
R2617 |
T10158 |
T10156 |
nsubjpass |
expression,upregulated |
R2618 |
T10159 |
T10158 |
compound |
luciferase,expression |
R2619 |
T10160 |
T10158 |
compound |
gene,expression |
R2620 |
T10161 |
T10156 |
auxpass |
was,upregulated |
R2621 |
T10162 |
T10156 |
neg |
not,upregulated |
R2622 |
T10163 |
T10164 |
advmod |
when,co-introduced |
R2623 |
T10164 |
T10156 |
advcl |
co-introduced,upregulated |
R2624 |
T10165 |
T10166 |
preconj |
both,Crx |
R2625 |
T10166 |
T10167 |
nmod |
Crx,vectors |
R2626 |
T10167 |
T10164 |
nsubjpass |
vectors,co-introduced |
R2627 |
T10168 |
T10166 |
cc |
and,Crx |
R2628 |
T10169 |
T10166 |
conj |
Nrl,Crx |
R2629 |
T10170 |
T10167 |
compound |
expression,vectors |
R2630 |
T10171 |
T10164 |
auxpass |
were,co-introduced |
R2631 |
T10172 |
T10164 |
prep |
with,co-introduced |
R2632 |
T10173 |
T10172 |
pobj |
Pro1.2k,with |
R2633 |
T10174 |
T10156 |
prep |
compared,upregulated |
R2634 |
T10175 |
T10174 |
prep |
to,compared |
R2635 |
T10176 |
T10177 |
det |
the,activity |
R2636 |
T10177 |
T10175 |
pobj |
activity,to |
R2637 |
T10178 |
T10179 |
advmod |
when,introduced |
R2638 |
T10179 |
T10177 |
relcl |
introduced,activity |
R2639 |
T10180 |
T10181 |
det |
the,vector |
R2640 |
T10181 |
T10179 |
nsubjpass |
vector,introduced |
R2641 |
T10182 |
T10181 |
nmod |
Crx,vector |
R2642 |
T10183 |
T10182 |
amod |
only,Crx |
R2643 |
T10184 |
T10181 |
compound |
expression,vector |
R2644 |
T10185 |
T10179 |
auxpass |
was,introduced |
R2645 |
T10186 |
T10147 |
punct |
.,showed |
R2646 |
T10188 |
T10189 |
nsubj |
This,be |
R2647 |
T10190 |
T10189 |
aux |
may,be |
R2648 |
T10191 |
T10189 |
prep |
due,be |
R2649 |
T10192 |
T10191 |
pcomp |
to,due |
R2650 |
T10193 |
T10194 |
compound |
cell,type |
R2651 |
T10194 |
T10195 |
compound |
type,differences |
R2652 |
T10195 |
T10191 |
pobj |
differences,due |
R2653 |
T10196 |
T10197 |
mark |
because,used |
R2654 |
T10197 |
T10189 |
advcl |
used,be |
R2655 |
T10198 |
T10199 |
det |
a,type |
R2656 |
T10199 |
T10197 |
nsubjpass |
type,used |
R2657 |
T10200 |
T10199 |
compound |
cell,type |
R2658 |
T10201 |
T10199 |
prep |
of,type |
R2659 |
T10202 |
T10203 |
amod |
retinal,pineal |
R2660 |
T10203 |
T10205 |
amod |
pineal,origin |
R2661 |
T10204 |
T10203 |
punct |
/,pineal |
R2662 |
T10205 |
T10201 |
pobj |
origin,of |
R2663 |
T10206 |
T10197 |
auxpass |
was,used |
R2664 |
T10207 |
T10197 |
neg |
not,used |
R2665 |
T10208 |
T10197 |
prep |
in,used |
R2666 |
T10209 |
T10210 |
poss |
our,assay |
R2667 |
T10210 |
T10208 |
pobj |
assay,in |
R2668 |
T10211 |
T10210 |
compound |
luciferase,assay |
R2669 |
T10212 |
T10189 |
punct |
.,be |
R2670 |
T10214 |
T10215 |
prep |
In,showed |
R2671 |
T10216 |
T10214 |
pobj |
addition,In |
R2672 |
T10217 |
T10215 |
punct |
", ",showed |
R2673 |
T10218 |
T10219 |
poss |
our,data |
R2674 |
T10219 |
T10215 |
nsubj |
data,showed |
R2675 |
T10220 |
T10219 |
amod |
present,data |
R2676 |
T10221 |
T10222 |
mark |
that,transactivated |
R2677 |
T10222 |
T10215 |
ccomp |
transactivated,showed |
R2678 |
T10223 |
T10222 |
nsubj |
Otx2,transactivated |
R2679 |
T10224 |
T10223 |
punct |
", ",Otx2 |
R2680 |
T10225 |
T10226 |
dep |
which,reported |
R2681 |
T10226 |
T10223 |
relcl |
reported,Otx2 |
R2682 |
T10227 |
T10226 |
auxpass |
is,reported |
R2683 |
T10228 |
T10229 |
aux |
to,have |
R2684 |
T10229 |
T10226 |
xcomp |
have,reported |
R2685 |
T10230 |
T10231 |
det |
the,consensus |
R2686 |
T10231 |
T10229 |
dobj |
consensus,have |
R2687 |
T10232 |
T10231 |
amod |
same,consensus |
R2688 |
T10233 |
T10231 |
compound |
binding,consensus |
R2689 |
T10234 |
T10231 |
prep |
as,consensus |
R2690 |
T10235 |
T10234 |
pobj |
Crx,as |
R2691 |
T10236 |
T10222 |
punct |
", ",transactivated |
R2692 |
T10237 |
T10222 |
advmod |
also,transactivated |
R2693 |
T10238 |
T10239 |
compound |
mr,s |
R2694 |
T10239 |
T10241 |
compound |
s,expression |
R2695 |
T10240 |
T10239 |
punct |
-,s |
R2696 |
T10241 |
T10222 |
dobj |
expression,transactivated |
R2697 |
T10242 |
T10215 |
punct |
.,showed |
R2698 |
T10244 |
T10245 |
mark |
As,shown |
R2699 |
T10245 |
T10246 |
advcl |
shown,correlates |
R2700 |
T10247 |
T10245 |
prep |
in,shown |
R2701 |
T10248 |
T10249 |
compound |
Fig.,2A |
R2702 |
T10249 |
T10247 |
pobj |
2A,in |
R2703 |
T10250 |
T10251 |
punct |
–,F |
R2704 |
T10251 |
T10249 |
prep |
F,2A |
R2705 |
T10252 |
T10246 |
punct |
", ",correlates |
R2706 |
T10253 |
T10254 |
det |
the,pattern |
R2707 |
T10254 |
T10246 |
nsubj |
pattern,correlates |
R2708 |
T10255 |
T10254 |
compound |
expression,pattern |
R2709 |
T10256 |
T10254 |
prep |
of,pattern |
R2710 |
T10257 |
T10258 |
compound |
mr,s |
R2711 |
T10258 |
T10256 |
pobj |
s,of |
R2712 |
T10259 |
T10258 |
punct |
-,s |
R2713 |
T10260 |
T10246 |
prep |
with,correlates |
R2714 |
T10261 |
T10260 |
pobj |
that,with |
R2715 |
T10262 |
T10261 |
prep |
of,that |
R2716 |
T10263 |
T10262 |
pobj |
Crx,of |
R2717 |
T10264 |
T10246 |
punct |
.,correlates |
R2718 |
T10266 |
T10267 |
prep |
In,detected |
R2719 |
T10268 |
T10266 |
pobj |
contrast,In |
R2720 |
T10269 |
T10267 |
punct |
", ",detected |
R2721 |
T10270 |
T10271 |
det |
the,transcripts |
R2722 |
T10271 |
T10267 |
nsubjpass |
transcripts,detected |
R2723 |
T10272 |
T10271 |
prep |
of,transcripts |
R2724 |
T10273 |
T10272 |
pobj |
Otx2,of |
R2725 |
T10274 |
T10267 |
auxpass |
are,detected |
R2726 |
T10275 |
T10267 |
advmod |
mainly,detected |
R2727 |
T10276 |
T10267 |
prep |
in,detected |
R2728 |
T10277 |
T10278 |
det |
the,layer |
R2729 |
T10278 |
T10276 |
pobj |
layer,in |
R2730 |
T10279 |
T10278 |
compound |
photoreceptor,layer |
R2731 |
T10280 |
T10267 |
prep |
at,detected |
R2732 |
T10281 |
T10282 |
amod |
embryonic,stages |
R2733 |
T10282 |
T10280 |
pobj |
stages,at |
R2734 |
T10283 |
T10267 |
punct |
.,detected |
R2735 |
T10285 |
T10286 |
advmod |
Therefore,concluded |
R2736 |
T10287 |
T10286 |
punct |
", ",concluded |
R2737 |
T10288 |
T10286 |
nsubj |
we,concluded |
R2738 |
T10289 |
T10290 |
mark |
that,regulated |
R2739 |
T10290 |
T10286 |
ccomp |
regulated,concluded |
R2740 |
T10291 |
T10292 |
compound |
mr,s |
R2741 |
T10292 |
T10294 |
compound |
s,transcription |
R2742 |
T10293 |
T10292 |
punct |
-,s |
R2743 |
T10294 |
T10290 |
nsubjpass |
transcription,regulated |
R2744 |
T10295 |
T10290 |
auxpass |
is,regulated |
R2745 |
T10296 |
T10290 |
advmod |
directly,regulated |
R2746 |
T10297 |
T10298 |
advmod |
mainly,by |
R2747 |
T10298 |
T10290 |
agent |
by,regulated |
R2748 |
T10299 |
T10298 |
pobj |
Crx,by |
R2749 |
T10300 |
T10286 |
punct |
.,concluded |