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PMC:1435744 / 15507-16433 JSONTXT 4 Projects

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Id Subject Object Predicate Lexical cue
T30382 0-3 NN denotes PCR
T30380 4-12 NN denotes reaction
T30384 12-13 . denotes .
T30385 13-58 sentence denotes (D-F) Crx transactivates mr-s transcription.
T30386 14-15 -LRB- denotes (
T30387 15-16 LS denotes D
T30389 16-17 SYM denotes -
T30390 17-18 LS denotes F
T30391 18-19 -RRB- denotes )
T30392 20-23 NN denotes Crx
T30388 24-38 VBZ denotes transactivates
T30393 39-41 NN denotes mr
T30395 41-42 HYPH denotes -
T30394 42-43 NN denotes s
T30396 44-57 NN denotes transcription
T30397 57-58 . denotes .
T30398 58-112 sentence denotes Reporter plasmids for the luciferase assay are shown.
T30399 59-67 NN denotes Reporter
T30400 68-76 NNS denotes plasmids
T30402 77-80 IN denotes for
T30403 81-84 DT denotes the
T30405 85-95 NN denotes luciferase
T30404 96-101 NN denotes assay
T30406 102-105 VBP denotes are
T30401 106-111 VBN denotes shown
T30407 111-112 . denotes .
T30408 112-156 sentence denotes Blue boxes represent Crx binding sites (D).
T30409 113-117 JJ denotes Blue
T30410 118-123 NNS denotes boxes
T30411 124-133 VBP denotes represent
T30412 134-137 NN denotes Crx
T30414 138-145 NN denotes binding
T30413 146-151 NNS denotes sites
T30415 152-153 -LRB- denotes (
T30416 153-154 NN denotes D
T30417 154-155 -RRB- denotes )
T30418 155-156 . denotes .
T30419 156-289 sentence denotes Relative activity of the luciferase is indicated when Pro1.2k was co-transfected with Crx, Otx2, Nrl, and Crx+Nrl, respectively (E).
T30420 157-165 JJ denotes Relative
T30421 166-174 NN denotes activity
T30423 175-177 IN denotes of
T30424 178-181 DT denotes the
T30425 182-192 NN denotes luciferase
T30426 193-195 VBZ denotes is
T30422 196-205 VBN denotes indicated
T30427 206-210 WRB denotes when
T30429 211-218 NN denotes Pro1.2k
T30430 219-222 VBD denotes was
T30428 223-237 VBN denotes co-transfected
T30431 238-242 IN denotes with
T30432 243-246 NN denotes Crx
T30433 246-248 , denotes ,
T30434 248-252 NN denotes Otx2
T30435 252-254 , denotes ,
T30436 254-257 NN denotes Nrl
T30437 257-259 , denotes ,
T30438 259-262 CC denotes and
T30439 263-266 NN denotes Crx
T30441 266-267 SYM denotes +
T30440 267-270 NN denotes Nrl
T30442 270-272 , denotes ,
T30443 272-284 RB denotes respectively
T30444 285-286 -LRB- denotes (
T30445 286-287 NN denotes E
T30446 287-288 -RRB- denotes )
T30447 288-289 . denotes .
T30448 289-476 sentence denotes Fold activation is indicated when Pro1.2k, mut1259, mut198, mut72 and mut all were co-transfected with the Crx expression vector (Crx+) or the empty vector (Crx-) into HEK293T cells (F).
T30449 290-294 NN denotes Fold
T30450 295-305 NN denotes activation
T30452 306-308 VBZ denotes is
T30451 309-318 VBN denotes indicated
T30453 319-323 WRB denotes when
T30455 324-331 NN denotes Pro1.2k
T30456 331-333 , denotes ,
T30457 333-340 NN denotes mut1259
T30458 340-342 , denotes ,
T30459 342-348 NN denotes mut198
T30460 348-350 , denotes ,
T30461 350-355 NN denotes mut72
T30462 356-359 CC denotes and
T30463 360-363 NN denotes mut
T30464 364-367 NN denotes all
T30465 368-372 VBD denotes were
T30454 373-387 VBN denotes co-transfected
T30466 388-392 IN denotes with
T30467 393-396 DT denotes the
T30469 397-400 NN denotes Crx
T30470 401-411 NN denotes expression
T30468 412-418 NN denotes vector
T30471 419-420 -LRB- denotes (
T30472 420-423 NN denotes Crx
T30473 423-424 SYM denotes +
T30474 424-425 -RRB- denotes )
T30475 426-428 CC denotes or
T30476 429-432 DT denotes the
T30478 433-438 JJ denotes empty
T30477 439-445 NN denotes vector
T30479 446-447 -LRB- denotes (
T30480 447-450 NN denotes Crx
T30481 450-451 SYM denotes -
T30482 451-452 -RRB- denotes )
T30483 453-457 IN denotes into
T30484 458-465 NN denotes HEK293T
T30485 466-471 NNS denotes cells
T30486 472-473 -LRB- denotes (
T30487 473-474 NN denotes F
T30488 474-475 -RRB- denotes )
T30489 475-476 . denotes .
T30490 476-521 sentence denotes Error bars represent standard error of mean.
T30491 477-482 NN denotes Error
T30492 483-487 NNS denotes bars
T30493 488-497 VBP denotes represent
T30494 498-506 JJ denotes standard
T30495 507-512 NN denotes error
T30496 513-515 IN denotes of
T30497 516-520 NN denotes mean
T30498 520-521 . denotes .
T9954 522-523 DT denotes T
T9953 522-528 sentence denotes To fur
T9955 523-524 NN denotes o
T9957 525-526 IN denotes f
T9956 526-527 VBN denotes u
T9958 527-528 NN denotes r
T9960 528-529 FW denotes t
T9959 528-536 sentence denotes ther exa
T9961 529-530 NN denotes h
T9962 530-531 NN denotes e
T9963 531-532 IN denotes r
T9964 533-534 NN denotes e
T9966 534-535 NN denotes x
T9965 535-536 NNS denotes a
T9968 536-537 NN denotes m
T9967 536-541 sentence denotes mine
T9969 537-539 NN denotes in
T9970 539-540 VBN denotes e
T9971 541-542 sentence denotes w
T9972 541-542 JJ denotes w
T9974 542-544 DT denotes he
T9973 542-549 sentence denotes hether
T9975 544-545 NNS denotes t
T9976 545-547 DT denotes he
T9977 547-548 NN denotes r
T9980 549-550 NN denotes C
T9978 549-551 sentence denotes Cr
T9979 550-551 NN denotes r
T9983 551-552 NN denotes x
T9981 551-555 sentence denotes x re
T9982 553-555 VBZ denotes re
T9984 555-556 sentence denotes g
T9985 555-556 NN denotes g
T9987 556-557 NN denotes u
T9986 556-561 sentence denotes ulate
T9988 557-558 NN denotes l
T9989 558-559 CC denotes a
T9990 559-561 RB denotes te
T9992 561-562 VBZ denotes s
T9991 561-570 sentence denotes s mr-s tr
T9994 563-564 NN denotes m
T9995 564-565 VBD denotes r
T9993 565-567 VBN denotes -s
T9996 568-569 IN denotes t
T9997 569-570 NN denotes r
T9999 570-571 NNS denotes a
T9998 570-573 sentence denotes ans
T10000 571-572 VBP denotes n
T10001 572-573 JJ denotes s
T10004 573-581 NN denotes cription
T10002 573-813 sentence denotes cription directly or not, we next performed a luciferase assay using the 1.2-kb proximal promoter region of mr-s fused to a luciferase gene as a luciferase reporter (Fig. 3D, Pro1.2k) and the Crx, Otx2, Nrl expression vectors, respectively.
T10005 582-590 RB denotes directly
T10006 591-593 CC denotes or
T10007 594-597 RB denotes not
T10008 597-599 , denotes ,
T10009 599-601 PRP denotes we
T10010 602-606 RB denotes next
T10003 607-616 VBD denotes performed
T10011 617-618 DT denotes a
T10013 619-629 NN denotes luciferase
T10012 630-635 NN denotes assay
T10014 636-641 VBG denotes using
T10015 642-645 DT denotes the
T10017 646-649 CD denotes 1.2
T10019 649-650 HYPH denotes -
T10018 650-652 NN denotes kb
T10020 653-661 JJ denotes proximal
T10021 662-670 NN denotes promoter
T10016 671-677 NN denotes region
T10022 678-680 IN denotes of
T10023 681-683 NN denotes mr
T10025 683-684 HYPH denotes -
T10024 684-685 NN denotes s
T10026 686-691 VBN denotes fused
T10027 692-694 IN denotes to
T10028 695-696 DT denotes a
T10030 697-707 NN denotes luciferase
T10029 708-712 NN denotes gene
T10031 713-715 IN denotes as
T10032 716-717 DT denotes a
T10034 718-728 NN denotes luciferase
T10033 729-737 NN denotes reporter
T10035 738-739 -LRB- denotes (
T10037 739-743 NN denotes Fig.
T10036 744-746 NN denotes 3D
T10038 746-748 , denotes ,
T10039 748-755 NN denotes Pro1.2k
T10040 755-756 -RRB- denotes )
T10041 757-760 CC denotes and
T10042 761-764 DT denotes the
T10044 765-768 NN denotes Crx
T10046 768-770 , denotes ,
T10047 770-774 NN denotes Otx2
T10048 774-776 , denotes ,
T10045 776-779 NN denotes Nrl
T10049 780-790 NN denotes expression
T10043 791-798 NNS denotes vectors
T10050 798-800 , denotes ,
T10051 800-812 RB denotes respectively
T10052 812-813 . denotes .
T10053 813-910 sentence denotes This 1.2-kb region of the mr-s upstream sequence contains three Crx binding consensus sequences.
T10054 814-818 DT denotes This
T10056 819-822 CD denotes 1.2
T10058 822-823 HYPH denotes -
T10057 823-825 NN denotes kb
T10055 826-832 NN denotes region
T10060 833-835 IN denotes of
T10061 836-839 DT denotes the
T10063 840-842 NN denotes mr
T10065 842-843 HYPH denotes -
T10064 843-844 NN denotes s
T10066 845-853 JJ denotes upstream
T10062 854-862 NN denotes sequence
T10059 863-871 VBZ denotes contains
T10067 872-877 CD denotes three
T10069 878-881 NN denotes Crx
T10070 882-889 NN denotes binding
T10071 890-899 NN denotes consensus
T10068 900-909 NNS denotes sequences
T10072 909-910 . denotes .
T10074 911-913 IN denotes As
T10075 914-919 VBN denotes shown
T10077 920-922 IN denotes in
R2463 T9954 T9955 det T,o
R2464 T9955 T9956 nsubjpass o,u
R2465 T9957 T9955 prep f,o
R2466 T9960 T9961 amod t,h
R2467 T9963 T9962 prep r,e
R2468 T9969 T9970 nsubjpass in,e
R2469 T9980 T9979 compound C,r
R2470 T9983 T9982 nsubj x,re
R2471 T9989 T9988 cc a,l
R2472 T9995 T9993 auxpass r,-s
R2473 T9996 T9993 prep t,-s
R2474 T9999 T10000 nsubj a,n
R2475 T10008 T10003 punct ", ",performed
R2476 T10009 T10003 nsubj we,performed
R2477 T10010 T10003 advmod next,performed
R2478 T10011 T10012 det a,assay
R2479 T10012 T10003 dobj assay,performed
R2480 T10013 T10012 compound luciferase,assay
R2481 T10014 T10003 advcl using,performed
R2482 T10015 T10016 det the,region
R2483 T10016 T10014 dobj region,using
R2484 T10017 T10018 nummod 1.2,kb
R2485 T10018 T10016 nmod kb,region
R2486 T10019 T10018 punct -,kb
R2487 T10020 T10016 amod proximal,region
R2488 T10021 T10016 compound promoter,region
R2489 T10022 T10016 prep of,region
R2490 T10023 T10024 compound mr,s
R2491 T10024 T10022 pobj s,of
R2492 T10025 T10024 punct -,s
R2493 T10026 T10016 acl fused,region
R2494 T10027 T10026 prep to,fused
R2495 T10028 T10029 det a,gene
R2496 T10029 T10027 pobj gene,to
R2497 T10030 T10029 compound luciferase,gene
R2498 T10031 T10029 prep as,gene
R2499 T10032 T10033 det a,reporter
R2500 T10033 T10031 pobj reporter,as
R2501 T10034 T10033 compound luciferase,reporter
R2502 T10035 T10036 punct (,3D
R2503 T10036 T10033 parataxis 3D,reporter
R2504 T10037 T10036 compound Fig.,3D
R2505 T10038 T10036 punct ", ",3D
R2506 T10039 T10036 appos Pro1.2k,3D
R2507 T10040 T10036 punct ),3D
R2508 T10041 T10029 cc and,gene
R2509 T10042 T10043 det the,vectors
R2510 T10043 T10029 conj vectors,gene
R2511 T10044 T10045 nmod Crx,Nrl
R2512 T10045 T10043 compound Nrl,vectors
R2513 T10046 T10045 punct ", ",Nrl
R2514 T10047 T10045 nmod Otx2,Nrl
R2515 T10048 T10045 punct ", ",Nrl
R2516 T10049 T10043 compound expression,vectors
R2517 T10050 T10026 punct ", ",fused
R2518 T10051 T10026 advmod respectively,fused
R2519 T10052 T10003 punct .,performed
R2520 T10054 T10055 det This,region
R2521 T10055 T10059 nsubj region,contains
R2522 T10056 T10057 nummod 1.2,kb
R2523 T10057 T10055 compound kb,region
R2524 T10058 T10057 punct -,kb
R2525 T10060 T10055 prep of,region
R2526 T10061 T10062 det the,sequence
R2527 T10062 T10060 pobj sequence,of
R2528 T10063 T10064 nmod mr,s
R2529 T10064 T10062 nmod s,sequence
R2530 T10065 T10064 punct -,s
R2531 T10066 T10062 amod upstream,sequence
R2532 T10067 T10068 nummod three,sequences
R2533 T10068 T10059 dobj sequences,contains
R2534 T10069 T10070 compound Crx,binding
R2535 T10070 T10068 compound binding,sequences
R2536 T10071 T10068 compound consensus,sequences
R2537 T10072 T10059 punct .,contains
R2538 T10074 T10075 mark As,shown
R2540 T10077 T10075 prep in,shown
R8692 T30382 T30380 compound PCR,reaction
R8695 T30386 T30387 punct (,D
R8696 T30387 T30388 meta D,transactivates
R8697 T30389 T30387 punct -,D
R8698 T30390 T30387 dep F,D
R8699 T30391 T30387 punct ),D
R8700 T30392 T30388 nsubj Crx,transactivates
R8701 T30393 T30394 compound mr,s
R8702 T30394 T30396 compound s,transcription
R8703 T30395 T30394 punct -,s
R8704 T30396 T30388 dobj transcription,transactivates
R8705 T30397 T30388 punct .,transactivates
R8706 T30399 T30400 compound Reporter,plasmids
R8707 T30400 T30401 nsubjpass plasmids,shown
R8708 T30402 T30400 prep for,plasmids
R8709 T30403 T30404 det the,assay
R8710 T30404 T30402 pobj assay,for
R8711 T30405 T30404 compound luciferase,assay
R8712 T30406 T30401 auxpass are,shown
R8713 T30407 T30401 punct .,shown
R8714 T30409 T30410 amod Blue,boxes
R8715 T30410 T30411 nsubj boxes,represent
R8716 T30412 T30413 compound Crx,sites
R8717 T30413 T30411 dobj sites,represent
R8718 T30414 T30413 compound binding,sites
R8719 T30415 T30416 punct (,D
R8720 T30416 T30411 parataxis D,represent
R8721 T30417 T30416 punct ),D
R8722 T30418 T30411 punct .,represent
R8723 T30420 T30421 amod Relative,activity
R8724 T30421 T30422 nsubjpass activity,indicated
R8725 T30423 T30421 prep of,activity
R8726 T30424 T30425 det the,luciferase
R8727 T30425 T30423 pobj luciferase,of
R8728 T30426 T30422 auxpass is,indicated
R8729 T30427 T30428 advmod when,co-transfected
R8730 T30428 T30422 advcl co-transfected,indicated
R8731 T30429 T30428 nsubjpass Pro1.2k,co-transfected
R8732 T30430 T30428 auxpass was,co-transfected
R8733 T30431 T30428 prep with,co-transfected
R8734 T30432 T30431 pobj Crx,with
R8735 T30433 T30432 punct ", ",Crx
R8736 T30434 T30432 conj Otx2,Crx
R8737 T30435 T30434 punct ", ",Otx2
R8738 T30436 T30434 conj Nrl,Otx2
R8739 T30437 T30436 punct ", ",Nrl
R8740 T30438 T30436 cc and,Nrl
R8741 T30439 T30440 nmod Crx,Nrl
R8742 T30440 T30436 conj Nrl,Nrl
R8743 T30441 T30440 punct +,Nrl
R8744 T30442 T30428 punct ", ",co-transfected
R8745 T30443 T30428 advmod respectively,co-transfected
R8746 T30444 T30445 punct (,E
R8747 T30445 T30428 parataxis E,co-transfected
R8748 T30446 T30445 punct ),E
R8749 T30447 T30422 punct .,indicated
R8750 T30449 T30450 compound Fold,activation
R8751 T30450 T30451 nsubjpass activation,indicated
R8752 T30452 T30451 auxpass is,indicated
R8753 T30453 T30454 advmod when,co-transfected
R8754 T30454 T30451 advcl co-transfected,indicated
R8755 T30455 T30454 nsubjpass Pro1.2k,co-transfected
R8756 T30456 T30455 punct ", ",Pro1.2k
R8757 T30457 T30455 conj mut1259,Pro1.2k
R8758 T30458 T30457 punct ", ",mut1259
R8759 T30459 T30457 conj mut198,mut1259
R8760 T30460 T30459 punct ", ",mut198
R8761 T30461 T30459 conj mut72,mut198
R8762 T30462 T30461 cc and,mut72
R8763 T30463 T30464 compound mut,all
R8764 T30464 T30461 conj all,mut72
R8765 T30465 T30454 auxpass were,co-transfected
R8766 T30466 T30454 prep with,co-transfected
R8767 T30467 T30468 det the,vector
R8768 T30468 T30466 pobj vector,with
R8769 T30469 T30468 compound Crx,vector
R8770 T30470 T30468 compound expression,vector
R8771 T30471 T30472 punct (,Crx
R8772 T30472 T30468 parataxis Crx,vector
R8773 T30473 T30472 punct +,Crx
R8774 T30474 T30472 punct ),Crx
R8775 T30475 T30468 cc or,vector
R8776 T30476 T30477 det the,vector
R8777 T30477 T30468 conj vector,vector
R8778 T30478 T30477 amod empty,vector
R8779 T30479 T30480 punct (,Crx
R8780 T30480 T30477 parataxis Crx,vector
R8781 T30481 T30480 punct -,Crx
R8782 T30482 T30480 punct ),Crx
R8783 T30483 T30454 prep into,co-transfected
R8784 T30484 T30485 compound HEK293T,cells
R8785 T30485 T30483 pobj cells,into
R8786 T30486 T30487 punct (,F
R8787 T30487 T30451 parataxis F,indicated
R8788 T30488 T30487 punct ),F
R8789 T30489 T30451 punct .,indicated
R8790 T30491 T30492 compound Error,bars
R8791 T30492 T30493 nsubj bars,represent
R8792 T30494 T30495 amod standard,error
R8793 T30495 T30493 dobj error,represent
R8794 T30496 T30495 prep of,error
R8795 T30497 T30496 pobj mean,of
R8796 T30498 T30493 punct .,represent