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PMC:1435744 / 14998-16028 JSONTXT 4 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T30251 0-3 DT denotes The
T30252 4-17 NN denotes transcription
T30254 18-20 IN denotes of
T30255 21-23 NN denotes mr
T30257 23-24 HYPH denotes -
T30256 24-25 NN denotes s
T30258 26-28 VBZ denotes is
T30253 29-38 VBN denotes regulated
T30259 39-41 IN denotes by
T30260 42-45 NN denotes Crx
T30261 45-46 . denotes .
T30262 46-169 sentence denotes (A, B) In situ hybridization using a probe for mouse mr-s was performed on the wild-type (A) and Crx KO retinas (B) at P5.
T30263 47-48 -LRB- denotes (
T30264 48-49 LS denotes A
T30266 49-51 , denotes ,
T30267 51-52 LS denotes B
T30268 52-53 -RRB- denotes )
T30269 54-56 FW denotes In
T30270 57-61 FW denotes situ
T30271 62-75 NN denotes hybridization
T30272 76-81 VBG denotes using
T30273 82-83 DT denotes a
T30274 84-89 NN denotes probe
T30275 90-93 IN denotes for
T30276 94-99 NN denotes mouse
T30278 100-102 NN denotes mr
T30279 102-103 HYPH denotes -
T30277 103-104 NN denotes s
T30280 105-108 VBD denotes was
T30265 109-118 VBN denotes performed
T30281 119-121 IN denotes on
T30282 122-125 DT denotes the
T30284 126-130 JJ denotes wild
T30286 130-131 HYPH denotes -
T30285 131-135 NN denotes type
T30287 136-137 -LRB- denotes (
T30288 137-138 NN denotes A
T30289 138-139 -RRB- denotes )
T30290 140-143 CC denotes and
T30291 144-147 NN denotes Crx
T30292 148-150 NN denotes KO
T30283 151-158 NNS denotes retinas
T30293 159-160 -LRB- denotes (
T30294 160-161 NN denotes B
T30295 161-162 -RRB- denotes )
T30296 163-165 IN denotes at
T30297 166-168 NN denotes P5
T30298 168-169 . denotes .
T30299 169-235 sentence denotes mr-s expression was drastically reduced in the Crx KO retina (B).
T30300 170-172 NN denotes mr
T30302 172-173 HYPH denotes -
T30301 173-174 NN denotes s
T30303 175-185 NN denotes expression
T30305 186-189 VBD denotes was
T30306 190-201 RB denotes drastically
T30304 202-209 VBN denotes reduced
T30307 210-212 IN denotes in
T30308 213-216 DT denotes the
T30310 217-220 NN denotes Crx
T30311 221-223 NN denotes KO
T30309 224-230 NN denotes retina
T30312 231-232 -LRB- denotes (
T30313 232-233 NN denotes B
T30314 233-234 -RRB- denotes )
T30315 234-235 . denotes .
T30316 235-254 sentence denotes Scale bar, 100 μm.
T30317 236-241 NN denotes Scale
T30318 242-245 NN denotes bar
T30319 245-247 , denotes ,
T30320 247-250 CD denotes 100
T30321 251-253 NN denotes μm
T30322 253-254 . denotes .
T30323 254-355 sentence denotes (C) RT-PCR analysis of total RNAs extracted from the pineal glands of P5 wild-type and Crx KO mouse.
T30324 255-256 -LRB- denotes (
T30325 256-257 LS denotes C
T30327 257-258 -RRB- denotes )
T30328 259-261 NN denotes RT
T30330 261-262 HYPH denotes -
T30329 262-265 NN denotes PCR
T30326 266-274 NN denotes analysis
T30331 275-277 IN denotes of
T30332 278-283 JJ denotes total
T30333 284-288 NNS denotes RNAs
T30334 289-298 VBN denotes extracted
T30335 299-303 IN denotes from
T30336 304-307 DT denotes the
T30338 308-314 JJ denotes pineal
T30337 315-321 NNS denotes glands
T30339 322-324 IN denotes of
T30340 325-327 NN denotes P5
T30342 328-332 JJ denotes wild
T30344 332-333 HYPH denotes -
T30343 333-337 NN denotes type
T30345 338-341 CC denotes and
T30346 342-345 NN denotes Crx
T30347 346-348 NN denotes KO
T30341 349-354 NN denotes mouse
T30348 354-355 . denotes .
T30349 355-478 sentence denotes The upper and lower lanes show PCR products amplified by the primer pairs specific for mr-s and G3PDH cDNAs, respectively.
T30350 356-359 DT denotes The
T30352 360-365 JJ denotes upper
T30353 366-369 CC denotes and
T30354 370-375 JJ denotes lower
T30351 376-381 NNS denotes lanes
T30355 382-386 VBP denotes show
T30356 387-390 NN denotes PCR
T30357 391-399 NNS denotes products
T30358 400-409 VBN denotes amplified
T30359 410-412 IN denotes by
T30360 413-416 DT denotes the
T30362 417-423 NN denotes primer
T30361 424-429 NNS denotes pairs
T30363 430-438 JJ denotes specific
T30364 439-442 IN denotes for
T30365 443-445 NN denotes mr
T30367 445-446 HYPH denotes -
T30366 446-447 NN denotes s
T30368 448-451 CC denotes and
T30369 452-457 NN denotes G3PDH
T30370 458-463 NNS denotes cDNAs
T30371 463-465 , denotes ,
T30372 465-477 RB denotes respectively
T30373 477-478 . denotes .
T30374 478-522 sentence denotes Water was used for control RT-PCR reaction.
T30375 479-484 NN denotes Water
T30377 485-488 VBD denotes was
T30376 489-493 VBN denotes used
T30378 494-497 IN denotes for
T30379 498-505 NN denotes control
T30381 506-508 NN denotes RT
T30383 508-509 HYPH denotes -
T30382 509-512 NN denotes PCR
T30380 513-521 NN denotes reaction
T30384 521-522 . denotes .
T30385 522-567 sentence denotes (D-F) Crx transactivates mr-s transcription.
T30386 523-524 -LRB- denotes (
T30387 524-525 LS denotes D
T30389 525-526 SYM denotes -
T30390 526-527 LS denotes F
T30391 527-528 -RRB- denotes )
T30392 529-532 NN denotes Crx
T30388 533-547 VBZ denotes transactivates
T30393 548-550 NN denotes mr
T30395 550-551 HYPH denotes -
T30394 551-552 NN denotes s
T30396 553-566 NN denotes transcription
T30397 566-567 . denotes .
T30398 567-621 sentence denotes Reporter plasmids for the luciferase assay are shown.
T30399 568-576 NN denotes Reporter
T30400 577-585 NNS denotes plasmids
T30402 586-589 IN denotes for
T30403 590-593 DT denotes the
T30405 594-604 NN denotes luciferase
T30404 605-610 NN denotes assay
T30406 611-614 VBP denotes are
T30401 615-620 VBN denotes shown
T30407 620-621 . denotes .
T30408 621-665 sentence denotes Blue boxes represent Crx binding sites (D).
T30409 622-626 JJ denotes Blue
T30410 627-632 NNS denotes boxes
T30411 633-642 VBP denotes represent
T30412 643-646 NN denotes Crx
T30414 647-654 NN denotes binding
T30413 655-660 NNS denotes sites
T30415 661-662 -LRB- denotes (
T30416 662-663 NN denotes D
T30417 663-664 -RRB- denotes )
T30418 664-665 . denotes .
T30419 665-798 sentence denotes Relative activity of the luciferase is indicated when Pro1.2k was co-transfected with Crx, Otx2, Nrl, and Crx+Nrl, respectively (E).
T30420 666-674 JJ denotes Relative
T30421 675-683 NN denotes activity
T30423 684-686 IN denotes of
T30424 687-690 DT denotes the
T30425 691-701 NN denotes luciferase
T30426 702-704 VBZ denotes is
T30422 705-714 VBN denotes indicated
T30427 715-719 WRB denotes when
T30429 720-727 NN denotes Pro1.2k
T30430 728-731 VBD denotes was
T30428 732-746 VBN denotes co-transfected
T30431 747-751 IN denotes with
T30432 752-755 NN denotes Crx
T30433 755-757 , denotes ,
T30434 757-761 NN denotes Otx2
T30435 761-763 , denotes ,
T30436 763-766 NN denotes Nrl
T30437 766-768 , denotes ,
T30438 768-771 CC denotes and
T30439 772-775 NN denotes Crx
T30441 775-776 SYM denotes +
T30440 776-779 NN denotes Nrl
T30442 779-781 , denotes ,
T30443 781-793 RB denotes respectively
T30444 794-795 -LRB- denotes (
T30445 795-796 NN denotes E
T30446 796-797 -RRB- denotes )
T30447 797-798 . denotes .
T30448 798-985 sentence denotes Fold activation is indicated when Pro1.2k, mut1259, mut198, mut72 and mut all were co-transfected with the Crx expression vector (Crx+) or the empty vector (Crx-) into HEK293T cells (F).
T30449 799-803 NN denotes Fold
T30450 804-814 NN denotes activation
T30452 815-817 VBZ denotes is
T30451 818-827 VBN denotes indicated
T30453 828-832 WRB denotes when
T30455 833-840 NN denotes Pro1.2k
T30456 840-842 , denotes ,
T30457 842-849 NN denotes mut1259
T30458 849-851 , denotes ,
T30459 851-857 NN denotes mut198
T30460 857-859 , denotes ,
T30461 859-864 NN denotes mut72
T30462 865-868 CC denotes and
T30463 869-872 NN denotes mut
T30464 873-876 NN denotes all
T30465 877-881 VBD denotes were
T30454 882-896 VBN denotes co-transfected
T30466 897-901 IN denotes with
T30467 902-905 DT denotes the
T30469 906-909 NN denotes Crx
T30470 910-920 NN denotes expression
T30468 921-927 NN denotes vector
T30471 928-929 -LRB- denotes (
T30472 929-932 NN denotes Crx
T30473 932-933 SYM denotes +
T30474 933-934 -RRB- denotes )
T30475 935-937 CC denotes or
T30476 938-941 DT denotes the
T30478 942-947 JJ denotes empty
T30477 948-954 NN denotes vector
T30479 955-956 -LRB- denotes (
T30480 956-959 NN denotes Crx
T30481 959-960 SYM denotes -
T30482 960-961 -RRB- denotes )
T30483 962-966 IN denotes into
T30484 967-974 NN denotes HEK293T
T30485 975-980 NNS denotes cells
T30486 981-982 -LRB- denotes (
T30487 982-983 NN denotes F
T30488 983-984 -RRB- denotes )
T30489 984-985 . denotes .
T30490 985-1030 sentence denotes Error bars represent standard error of mean.
T30491 986-991 NN denotes Error
T30492 992-996 NNS denotes bars
T30493 997-1006 VBP denotes represent
T30494 1007-1015 JJ denotes standard
T30495 1016-1021 NN denotes error
T30496 1022-1024 IN denotes of
T30497 1025-1029 NN denotes mean
T30498 1029-1030 . denotes .
R8574 T30251 T30252 det The,transcription
R8575 T30252 T30253 nsubjpass transcription,regulated
R8576 T30254 T30252 prep of,transcription
R8577 T30255 T30256 compound mr,s
R8578 T30256 T30254 pobj s,of
R8579 T30257 T30256 punct -,s
R8580 T30258 T30253 auxpass is,regulated
R8581 T30259 T30253 agent by,regulated
R8582 T30260 T30259 pobj Crx,by
R8583 T30261 T30253 punct .,regulated
R8584 T30263 T30264 punct (,A
R8585 T30264 T30265 meta A,performed
R8586 T30266 T30264 punct ", ",A
R8587 T30267 T30264 dep B,A
R8588 T30268 T30264 punct ),A
R8589 T30269 T30270 advmod In,situ
R8590 T30270 T30271 amod situ,hybridization
R8591 T30271 T30265 nsubjpass hybridization,performed
R8592 T30272 T30271 acl using,hybridization
R8593 T30273 T30274 det a,probe
R8594 T30274 T30272 dobj probe,using
R8595 T30275 T30274 prep for,probe
R8596 T30276 T30277 compound mouse,s
R8597 T30277 T30275 pobj s,for
R8598 T30278 T30277 compound mr,s
R8599 T30279 T30277 punct -,s
R8600 T30280 T30265 auxpass was,performed
R8601 T30281 T30265 prep on,performed
R8602 T30282 T30283 det the,retinas
R8603 T30283 T30281 pobj retinas,on
R8604 T30284 T30285 amod wild,type
R8605 T30285 T30283 nmod type,retinas
R8606 T30286 T30285 punct -,type
R8607 T30287 T30288 punct (,A
R8608 T30288 T30285 parataxis A,type
R8609 T30289 T30288 punct ),A
R8610 T30290 T30285 cc and,type
R8611 T30291 T30292 compound Crx,KO
R8612 T30292 T30285 conj KO,type
R8613 T30293 T30294 punct (,B
R8614 T30294 T30283 parataxis B,retinas
R8615 T30295 T30294 punct ),B
R8616 T30296 T30265 prep at,performed
R8617 T30297 T30296 pobj P5,at
R8618 T30298 T30265 punct .,performed
R8619 T30300 T30301 compound mr,s
R8620 T30301 T30303 compound s,expression
R8621 T30302 T30301 punct -,s
R8622 T30303 T30304 nsubjpass expression,reduced
R8623 T30305 T30304 auxpass was,reduced
R8624 T30306 T30304 advmod drastically,reduced
R8625 T30307 T30304 prep in,reduced
R8626 T30308 T30309 det the,retina
R8627 T30309 T30307 pobj retina,in
R8628 T30310 T30311 compound Crx,KO
R8629 T30311 T30309 compound KO,retina
R8630 T30312 T30313 punct (,B
R8631 T30313 T30309 parataxis B,retina
R8632 T30314 T30313 punct ),B
R8633 T30315 T30304 punct .,reduced
R8634 T30317 T30318 compound Scale,bar
R8635 T30319 T30318 punct ", ",bar
R8636 T30320 T30321 nummod 100,μm
R8637 T30321 T30318 appos μm,bar
R8638 T30322 T30318 punct .,bar
R8639 T30324 T30325 punct (,C
R8640 T30325 T30326 meta C,analysis
R8641 T30327 T30325 punct ),C
R8642 T30328 T30329 compound RT,PCR
R8643 T30329 T30326 compound PCR,analysis
R8644 T30330 T30329 punct -,PCR
R8645 T30331 T30326 prep of,analysis
R8646 T30332 T30333 amod total,RNAs
R8647 T30333 T30331 pobj RNAs,of
R8648 T30334 T30333 acl extracted,RNAs
R8649 T30335 T30334 prep from,extracted
R8650 T30336 T30337 det the,glands
R8651 T30337 T30335 pobj glands,from
R8652 T30338 T30337 amod pineal,glands
R8653 T30339 T30337 prep of,glands
R8654 T30340 T30341 nmod P5,mouse
R8655 T30341 T30339 pobj mouse,of
R8656 T30342 T30343 amod wild,type
R8657 T30343 T30341 nmod type,mouse
R8658 T30344 T30343 punct -,type
R8659 T30345 T30343 cc and,type
R8660 T30346 T30347 compound Crx,KO
R8661 T30347 T30343 conj KO,type
R8662 T30348 T30326 punct .,analysis
R8663 T30350 T30351 det The,lanes
R8664 T30351 T30355 nsubj lanes,show
R8665 T30352 T30351 amod upper,lanes
R8666 T30353 T30352 cc and,upper
R8667 T30354 T30352 conj lower,upper
R8668 T30356 T30357 compound PCR,products
R8669 T30357 T30355 dobj products,show
R8670 T30358 T30357 acl amplified,products
R8671 T30359 T30358 agent by,amplified
R8672 T30360 T30361 det the,pairs
R8673 T30361 T30359 pobj pairs,by
R8674 T30362 T30361 compound primer,pairs
R8675 T30363 T30361 amod specific,pairs
R8676 T30364 T30363 prep for,specific
R8677 T30365 T30366 compound mr,s
R8678 T30366 T30364 pobj s,for
R8679 T30367 T30366 punct -,s
R8680 T30368 T30366 cc and,s
R8681 T30369 T30370 compound G3PDH,cDNAs
R8682 T30370 T30366 conj cDNAs,s
R8683 T30371 T30358 punct ", ",amplified
R8684 T30372 T30358 advmod respectively,amplified
R8685 T30373 T30355 punct .,show
R8686 T30375 T30376 nsubjpass Water,used
R8687 T30377 T30376 auxpass was,used
R8688 T30378 T30376 prep for,used
R8689 T30379 T30380 compound control,reaction
R8690 T30380 T30378 pobj reaction,for
R8691 T30381 T30382 compound RT,PCR
R8692 T30382 T30380 compound PCR,reaction
R8693 T30383 T30382 punct -,PCR
R8694 T30384 T30376 punct .,used
R8695 T30386 T30387 punct (,D
R8696 T30387 T30388 meta D,transactivates
R8697 T30389 T30387 punct -,D
R8698 T30390 T30387 dep F,D
R8699 T30391 T30387 punct ),D
R8700 T30392 T30388 nsubj Crx,transactivates
R8701 T30393 T30394 compound mr,s
R8702 T30394 T30396 compound s,transcription
R8703 T30395 T30394 punct -,s
R8704 T30396 T30388 dobj transcription,transactivates
R8705 T30397 T30388 punct .,transactivates
R8706 T30399 T30400 compound Reporter,plasmids
R8707 T30400 T30401 nsubjpass plasmids,shown
R8708 T30402 T30400 prep for,plasmids
R8709 T30403 T30404 det the,assay
R8710 T30404 T30402 pobj assay,for
R8711 T30405 T30404 compound luciferase,assay
R8712 T30406 T30401 auxpass are,shown
R8713 T30407 T30401 punct .,shown
R8714 T30409 T30410 amod Blue,boxes
R8715 T30410 T30411 nsubj boxes,represent
R8716 T30412 T30413 compound Crx,sites
R8717 T30413 T30411 dobj sites,represent
R8718 T30414 T30413 compound binding,sites
R8719 T30415 T30416 punct (,D
R8720 T30416 T30411 parataxis D,represent
R8721 T30417 T30416 punct ),D
R8722 T30418 T30411 punct .,represent
R8723 T30420 T30421 amod Relative,activity
R8724 T30421 T30422 nsubjpass activity,indicated
R8725 T30423 T30421 prep of,activity
R8726 T30424 T30425 det the,luciferase
R8727 T30425 T30423 pobj luciferase,of
R8728 T30426 T30422 auxpass is,indicated
R8729 T30427 T30428 advmod when,co-transfected
R8730 T30428 T30422 advcl co-transfected,indicated
R8731 T30429 T30428 nsubjpass Pro1.2k,co-transfected
R8732 T30430 T30428 auxpass was,co-transfected
R8733 T30431 T30428 prep with,co-transfected
R8734 T30432 T30431 pobj Crx,with
R8735 T30433 T30432 punct ", ",Crx
R8736 T30434 T30432 conj Otx2,Crx
R8737 T30435 T30434 punct ", ",Otx2
R8738 T30436 T30434 conj Nrl,Otx2
R8739 T30437 T30436 punct ", ",Nrl
R8740 T30438 T30436 cc and,Nrl
R8741 T30439 T30440 nmod Crx,Nrl
R8742 T30440 T30436 conj Nrl,Nrl
R8743 T30441 T30440 punct +,Nrl
R8744 T30442 T30428 punct ", ",co-transfected
R8745 T30443 T30428 advmod respectively,co-transfected
R8746 T30444 T30445 punct (,E
R8747 T30445 T30428 parataxis E,co-transfected
R8748 T30446 T30445 punct ),E
R8749 T30447 T30422 punct .,indicated
R8750 T30449 T30450 compound Fold,activation
R8751 T30450 T30451 nsubjpass activation,indicated
R8752 T30452 T30451 auxpass is,indicated
R8753 T30453 T30454 advmod when,co-transfected
R8754 T30454 T30451 advcl co-transfected,indicated
R8755 T30455 T30454 nsubjpass Pro1.2k,co-transfected
R8756 T30456 T30455 punct ", ",Pro1.2k
R8757 T30457 T30455 conj mut1259,Pro1.2k
R8758 T30458 T30457 punct ", ",mut1259
R8759 T30459 T30457 conj mut198,mut1259
R8760 T30460 T30459 punct ", ",mut198
R8761 T30461 T30459 conj mut72,mut198
R8762 T30462 T30461 cc and,mut72
R8763 T30463 T30464 compound mut,all
R8764 T30464 T30461 conj all,mut72
R8765 T30465 T30454 auxpass were,co-transfected
R8766 T30466 T30454 prep with,co-transfected
R8767 T30467 T30468 det the,vector
R8768 T30468 T30466 pobj vector,with
R8769 T30469 T30468 compound Crx,vector
R8770 T30470 T30468 compound expression,vector
R8771 T30471 T30472 punct (,Crx
R8772 T30472 T30468 parataxis Crx,vector
R8773 T30473 T30472 punct +,Crx
R8774 T30474 T30472 punct ),Crx
R8775 T30475 T30468 cc or,vector
R8776 T30476 T30477 det the,vector
R8777 T30477 T30468 conj vector,vector
R8778 T30478 T30477 amod empty,vector
R8779 T30479 T30480 punct (,Crx
R8780 T30480 T30477 parataxis Crx,vector
R8781 T30481 T30480 punct -,Crx
R8782 T30482 T30480 punct ),Crx
R8783 T30483 T30454 prep into,co-transfected
R8784 T30484 T30485 compound HEK293T,cells
R8785 T30485 T30483 pobj cells,into
R8786 T30486 T30487 punct (,F
R8787 T30487 T30451 parataxis F,indicated
R8788 T30488 T30487 punct ),F
R8789 T30489 T30451 punct .,indicated
R8790 T30491 T30492 compound Error,bars
R8791 T30492 T30493 nsubj bars,represent
R8792 T30494 T30495 amod standard,error
R8793 T30495 T30493 dobj error,represent
R8794 T30496 T30495 prep of,error
R8795 T30497 T30496 pobj mean,of
R8796 T30498 T30493 punct .,represent