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PMC:1435744 / 13924-14987 JSONTXT 4 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T9726 0-13 NN denotes Transcription
T9727 14-21 NNS denotes factors
T9729 22-26 NN denotes Otx2
T9730 27-30 CC denotes and
T9731 31-34 NN denotes Crx
T9732 35-38 VBP denotes are
T9728 39-44 VBN denotes known
T9733 45-47 TO denotes to
T9734 48-50 VB denotes be
T9735 51-54 JJ denotes key
T9736 55-65 NNS denotes regulators
T9737 66-68 IN denotes of
T9738 69-76 JJ denotes retinal
T9740 77-90 NN denotes photoreceptor
T9739 91-102 NN denotes development
T9741 103-104 -LRB- denotes [
T9743 104-105 CD denotes 3
T9744 105-106 , denotes ,
T9745 106-107 CD denotes 8
T9746 107-108 , denotes ,
T9742 108-109 CD denotes 9
T9747 109-110 -RRB- denotes ]
T9748 110-111 . denotes .
T9749 111-319 sentence denotes Although both Otx2 and Crx are expressed in developing photoreceptor cells in the embryonic retina, only Crx is highly expressed in the postnatal photoreceptors, suggesting that mr-s may be regulated by Crx.
T9750 112-120 IN denotes Although
T9752 121-125 CC denotes both
T9753 126-130 NN denotes Otx2
T9754 131-134 CC denotes and
T9755 135-138 NN denotes Crx
T9756 139-142 VBP denotes are
T9751 143-152 VBN denotes expressed
T9758 153-155 IN denotes in
T9759 156-166 VBG denotes developing
T9761 167-180 NN denotes photoreceptor
T9760 181-186 NNS denotes cells
T9762 187-189 IN denotes in
T9763 190-193 DT denotes the
T9765 194-203 JJ denotes embryonic
T9764 204-210 NN denotes retina
T9766 210-212 , denotes ,
T9767 212-216 RB denotes only
T9768 217-220 NN denotes Crx
T9769 221-223 VBZ denotes is
T9770 224-230 RB denotes highly
T9757 231-240 VBN denotes expressed
T9771 241-243 IN denotes in
T9772 244-247 DT denotes the
T9774 248-257 JJ denotes postnatal
T9773 258-272 NNS denotes photoreceptors
T9775 272-274 , denotes ,
T9776 274-284 VBG denotes suggesting
T9777 285-289 IN denotes that
T9779 290-292 NN denotes mr
T9781 292-293 HYPH denotes -
T9780 293-294 NN denotes s
T9782 295-298 MD denotes may
T9783 299-301 VB denotes be
T9778 302-311 VBN denotes regulated
T9784 312-314 IN denotes by
T9785 315-318 NN denotes Crx
T9786 318-319 . denotes .
T9787 319-466 sentence denotes To test whether Crx regulates mr-s transcription, we performed in situ hybridization of mr-s mRNA on wild-type and Crx KO P5 retinas (Fig. 3A, B).
T9788 320-322 TO denotes To
T9789 323-327 VB denotes test
T9791 328-335 IN denotes whether
T9793 336-339 NN denotes Crx
T9792 340-349 VBZ denotes regulates
T9794 350-352 NN denotes mr
T9796 352-353 HYPH denotes -
T9795 353-354 NN denotes s
T9797 355-368 NN denotes transcription
T9798 368-370 , denotes ,
T9799 370-372 PRP denotes we
T9790 373-382 VBD denotes performed
T9800 383-385 FW denotes in
T9801 386-390 FW denotes situ
T9802 391-404 NN denotes hybridization
T9803 405-407 IN denotes of
T9804 408-410 NN denotes mr
T9806 410-411 HYPH denotes -
T9805 411-412 NN denotes s
T9807 413-417 NN denotes mRNA
T9808 418-420 IN denotes on
T9809 421-425 JJ denotes wild
T9811 425-426 HYPH denotes -
T9810 426-430 NN denotes type
T9813 431-434 CC denotes and
T9814 435-438 NN denotes Crx
T9815 439-441 NN denotes KO
T9816 442-444 NN denotes P5
T9812 445-452 NNS denotes retinas
T9817 453-454 -LRB- denotes (
T9819 454-458 NN denotes Fig.
T9820 459-461 NN denotes 3A
T9821 461-463 , denotes ,
T9818 463-464 NN denotes B
T9822 464-465 -RRB- denotes )
T9823 465-466 . denotes .
T9824 466-544 sentence denotes In the Crx KO retina, the mr-s transcript was dramatically reduced (Fig. 3B).
T9825 467-469 IN denotes In
T9827 470-473 DT denotes the
T9829 474-477 NN denotes Crx
T9830 478-480 NN denotes KO
T9828 481-487 NN denotes retina
T9831 487-489 , denotes ,
T9832 489-492 DT denotes the
T9834 493-495 NN denotes mr
T9836 495-496 HYPH denotes -
T9835 496-497 NN denotes s
T9833 498-508 NN denotes transcript
T9837 509-512 VBD denotes was
T9838 513-525 RB denotes dramatically
T9826 526-533 VBN denotes reduced
T9839 534-535 -LRB- denotes (
T9841 535-539 NN denotes Fig.
T9840 540-542 NN denotes 3B
T9842 542-543 -RRB- denotes )
T9843 543-544 . denotes .
T9844 544-610 sentence denotes This indicates that Crx is essential for transactivation of mr-s.
T9845 545-549 DT denotes This
T9846 550-559 VBZ denotes indicates
T9847 560-564 IN denotes that
T9849 565-568 NN denotes Crx
T9848 569-571 VBZ denotes is
T9850 572-581 JJ denotes essential
T9851 582-585 IN denotes for
T9852 586-601 NN denotes transactivation
T9853 602-604 IN denotes of
T9854 605-607 NN denotes mr
T9856 607-608 HYPH denotes -
T9855 608-609 NN denotes s
T9857 609-610 . denotes .
T9858 610-827 sentence denotes Moreover, to test whether the transcription of mr-s is also regulated by Crx in the pineal gland, RT-PCR analysis was used to compare transcriptional levels of mr-s in P28 wild-type and Crx KO pineal gland (Fig. 3C).
T9859 611-619 RB denotes Moreover
T9861 619-621 , denotes ,
T9862 621-623 TO denotes to
T9863 624-628 VB denotes test
T9864 629-636 IN denotes whether
T9866 637-640 DT denotes the
T9867 641-654 NN denotes transcription
T9868 655-657 IN denotes of
T9869 658-660 NN denotes mr
T9871 660-661 HYPH denotes -
T9870 661-662 NN denotes s
T9872 663-665 VBZ denotes is
T9873 666-670 RB denotes also
T9865 671-680 VBN denotes regulated
T9874 681-683 IN denotes by
T9875 684-687 NN denotes Crx
T9876 688-690 IN denotes in
T9877 691-694 DT denotes the
T9879 695-701 JJ denotes pineal
T9878 702-707 NN denotes gland
T9880 707-709 , denotes ,
T9881 709-711 NN denotes RT
T9883 711-712 HYPH denotes -
T9882 712-715 NN denotes PCR
T9884 716-724 NN denotes analysis
T9885 725-728 VBD denotes was
T9860 729-733 VBN denotes used
T9886 734-736 TO denotes to
T9887 737-744 VB denotes compare
T9888 745-760 JJ denotes transcriptional
T9889 761-767 NNS denotes levels
T9890 768-770 IN denotes of
T9891 771-773 NN denotes mr
T9893 773-774 HYPH denotes -
T9892 774-775 NN denotes s
T9894 776-778 IN denotes in
T9895 779-782 NN denotes P28
T9897 783-787 JJ denotes wild
T9899 787-788 HYPH denotes -
T9898 788-792 NN denotes type
T9900 793-796 CC denotes and
T9901 797-800 NN denotes Crx
T9902 801-803 NN denotes KO
T9903 804-810 JJ denotes pineal
T9896 811-816 NN denotes gland
T9904 817-818 -LRB- denotes (
T9906 818-822 NN denotes Fig.
T9905 823-825 NN denotes 3C
T9907 825-826 -RRB- denotes )
T9908 826-827 . denotes .
T9909 827-932 sentence denotes The results revealed that mr-s transcription was significantly downregulated in the Crx KO pineal gland.
T9910 828-831 DT denotes The
T9911 832-839 NNS denotes results
T9912 840-848 VBD denotes revealed
T9913 849-853 IN denotes that
T9915 854-856 NN denotes mr
T9917 856-857 HYPH denotes -
T9916 857-858 NN denotes s
T9918 859-872 NN denotes transcription
T9919 873-876 VBD denotes was
T9920 877-890 RB denotes significantly
T9914 891-904 VBN denotes downregulated
T9921 905-907 IN denotes in
T9922 908-911 DT denotes the
T9924 912-915 NN denotes Crx
T9925 916-918 NN denotes KO
T9926 919-925 JJ denotes pineal
T9923 926-931 NN denotes gland
T9927 931-932 . denotes .
T9928 932-1063 sentence denotes Taken together, these data indicate that mr-s transcription is regulated by Crx in the developing photoreceptors and pineal gland.
T9929 933-938 VBN denotes Taken
T9931 939-947 RB denotes together
T9932 947-949 , denotes ,
T9933 949-954 DT denotes these
T9934 955-959 NNS denotes data
T9930 960-968 VBP denotes indicate
T9935 969-973 IN denotes that
T9937 974-976 NN denotes mr
T9939 976-977 HYPH denotes -
T9938 977-978 NN denotes s
T9940 979-992 NN denotes transcription
T9941 993-995 VBZ denotes is
T9936 996-1005 VBN denotes regulated
T9942 1006-1008 IN denotes by
T9943 1009-1012 NN denotes Crx
T9944 1013-1015 IN denotes in
T9945 1016-1019 DT denotes the
T9947 1020-1030 VBG denotes developing
T9946 1031-1045 NNS denotes photoreceptors
T9948 1046-1049 CC denotes and
T9949 1050-1056 JJ denotes pineal
T9950 1057-1062 NN denotes gland
T9951 1062-1063 . denotes .
R2252 T9726 T9727 compound Transcription,factors
R2253 T9727 T9728 nsubjpass factors,known
R2254 T9729 T9727 appos Otx2,factors
R2255 T9730 T9729 cc and,Otx2
R2256 T9731 T9729 conj Crx,Otx2
R2257 T9732 T9728 auxpass are,known
R2258 T9733 T9734 aux to,be
R2259 T9734 T9728 xcomp be,known
R2260 T9735 T9736 amod key,regulators
R2261 T9736 T9734 attr regulators,be
R2262 T9737 T9736 prep of,regulators
R2263 T9738 T9739 amod retinal,development
R2264 T9739 T9737 pobj development,of
R2265 T9740 T9739 compound photoreceptor,development
R2266 T9741 T9742 punct [,9
R2267 T9742 T9728 parataxis 9,known
R2268 T9743 T9742 nummod 3,9
R2269 T9744 T9742 punct ",",9
R2270 T9745 T9742 nummod 8,9
R2271 T9746 T9742 punct ",",9
R2272 T9747 T9742 punct ],9
R2273 T9748 T9728 punct .,known
R2274 T9750 T9751 mark Although,expressed
R2275 T9751 T9757 advcl expressed,expressed
R2276 T9752 T9753 preconj both,Otx2
R2277 T9753 T9751 nsubjpass Otx2,expressed
R2278 T9754 T9753 cc and,Otx2
R2279 T9755 T9753 conj Crx,Otx2
R2280 T9756 T9751 auxpass are,expressed
R2281 T9758 T9751 prep in,expressed
R2282 T9759 T9760 amod developing,cells
R2283 T9760 T9758 pobj cells,in
R2284 T9761 T9760 compound photoreceptor,cells
R2285 T9762 T9751 prep in,expressed
R2286 T9763 T9764 det the,retina
R2287 T9764 T9762 pobj retina,in
R2288 T9765 T9764 amod embryonic,retina
R2289 T9766 T9757 punct ", ",expressed
R2290 T9767 T9768 advmod only,Crx
R2291 T9768 T9757 nsubjpass Crx,expressed
R2292 T9769 T9757 auxpass is,expressed
R2293 T9770 T9757 advmod highly,expressed
R2294 T9771 T9757 prep in,expressed
R2295 T9772 T9773 det the,photoreceptors
R2296 T9773 T9771 pobj photoreceptors,in
R2297 T9774 T9773 amod postnatal,photoreceptors
R2298 T9775 T9757 punct ", ",expressed
R2299 T9776 T9757 advcl suggesting,expressed
R2300 T9777 T9778 mark that,regulated
R2301 T9778 T9776 ccomp regulated,suggesting
R2302 T9779 T9780 compound mr,s
R2303 T9780 T9778 nsubjpass s,regulated
R2304 T9781 T9780 punct -,s
R2305 T9782 T9778 aux may,regulated
R2306 T9783 T9778 auxpass be,regulated
R2307 T9784 T9778 agent by,regulated
R2308 T9785 T9784 pobj Crx,by
R2309 T9786 T9757 punct .,expressed
R2310 T9788 T9789 aux To,test
R2311 T9789 T9790 advcl test,performed
R2312 T9791 T9792 mark whether,regulates
R2313 T9792 T9789 ccomp regulates,test
R2314 T9793 T9792 nsubj Crx,regulates
R2315 T9794 T9795 compound mr,s
R2316 T9795 T9797 compound s,transcription
R2317 T9796 T9795 punct -,s
R2318 T9797 T9792 dobj transcription,regulates
R2319 T9798 T9790 punct ", ",performed
R2320 T9799 T9790 nsubj we,performed
R2321 T9800 T9801 advmod in,situ
R2322 T9801 T9802 amod situ,hybridization
R2323 T9802 T9790 dobj hybridization,performed
R2324 T9803 T9802 prep of,hybridization
R2325 T9804 T9805 compound mr,s
R2326 T9805 T9807 compound s,mRNA
R2327 T9806 T9805 punct -,s
R2328 T9807 T9803 pobj mRNA,of
R2329 T9808 T9790 prep on,performed
R2330 T9809 T9810 amod wild,type
R2331 T9810 T9812 nmod type,retinas
R2332 T9811 T9810 punct -,type
R2333 T9812 T9808 pobj retinas,on
R2334 T9813 T9810 cc and,type
R2335 T9814 T9815 compound Crx,KO
R2336 T9815 T9810 conj KO,type
R2337 T9816 T9812 compound P5,retinas
R2338 T9817 T9818 punct (,B
R2339 T9818 T9790 parataxis B,performed
R2340 T9819 T9818 nmod Fig.,B
R2341 T9820 T9818 nmod 3A,B
R2342 T9821 T9818 punct ", ",B
R2343 T9822 T9818 punct ),B
R2344 T9823 T9790 punct .,performed
R2345 T9825 T9826 prep In,reduced
R2346 T9827 T9828 det the,retina
R2347 T9828 T9825 pobj retina,In
R2348 T9829 T9830 compound Crx,KO
R2349 T9830 T9828 compound KO,retina
R2350 T9831 T9826 punct ", ",reduced
R2351 T9832 T9833 det the,transcript
R2352 T9833 T9826 nsubjpass transcript,reduced
R2353 T9834 T9835 compound mr,s
R2354 T9835 T9833 compound s,transcript
R2355 T9836 T9835 punct -,s
R2356 T9837 T9826 auxpass was,reduced
R2357 T9838 T9826 advmod dramatically,reduced
R2358 T9839 T9840 punct (,3B
R2359 T9840 T9826 parataxis 3B,reduced
R2360 T9841 T9840 compound Fig.,3B
R2361 T9842 T9840 punct ),3B
R2362 T9843 T9826 punct .,reduced
R2363 T9845 T9846 nsubj This,indicates
R2364 T9847 T9848 mark that,is
R2365 T9848 T9846 ccomp is,indicates
R2366 T9849 T9848 nsubj Crx,is
R2367 T9850 T9848 acomp essential,is
R2368 T9851 T9850 prep for,essential
R2369 T9852 T9851 pobj transactivation,for
R2370 T9853 T9852 prep of,transactivation
R2371 T9854 T9855 compound mr,s
R2372 T9855 T9853 pobj s,of
R2373 T9856 T9855 punct -,s
R2374 T9857 T9846 punct .,indicates
R2375 T9859 T9860 advmod Moreover,used
R2376 T9861 T9860 punct ", ",used
R2377 T9862 T9863 aux to,test
R2378 T9863 T9860 advcl test,used
R2379 T9864 T9865 mark whether,regulated
R2380 T9865 T9863 ccomp regulated,test
R2381 T9866 T9867 det the,transcription
R2382 T9867 T9865 nsubjpass transcription,regulated
R2383 T9868 T9867 prep of,transcription
R2384 T9869 T9870 compound mr,s
R2385 T9870 T9868 pobj s,of
R2386 T9871 T9870 punct -,s
R2387 T9872 T9865 auxpass is,regulated
R2388 T9873 T9865 advmod also,regulated
R2389 T9874 T9865 agent by,regulated
R2390 T9875 T9874 pobj Crx,by
R2391 T9876 T9865 prep in,regulated
R2392 T9877 T9878 det the,gland
R2393 T9878 T9876 pobj gland,in
R2394 T9879 T9878 amod pineal,gland
R2395 T9880 T9860 punct ", ",used
R2396 T9881 T9882 compound RT,PCR
R2397 T9882 T9884 compound PCR,analysis
R2398 T9883 T9882 punct -,PCR
R2399 T9884 T9860 nsubjpass analysis,used
R2400 T9885 T9860 auxpass was,used
R2401 T9886 T9887 aux to,compare
R2402 T9887 T9860 advcl compare,used
R2403 T9888 T9889 amod transcriptional,levels
R2404 T9889 T9887 dobj levels,compare
R2405 T9890 T9889 prep of,levels
R2406 T9891 T9892 compound mr,s
R2407 T9892 T9890 pobj s,of
R2408 T9893 T9892 punct -,s
R2409 T9894 T9887 prep in,compare
R2410 T9895 T9896 nmod P28,gland
R2411 T9896 T9894 pobj gland,in
R2412 T9897 T9898 amod wild,type
R2413 T9898 T9896 nmod type,gland
R2414 T9899 T9898 punct -,type
R2415 T9900 T9898 cc and,type
R2416 T9901 T9902 compound Crx,KO
R2417 T9902 T9898 conj KO,type
R2418 T9903 T9896 amod pineal,gland
R2419 T9904 T9905 punct (,3C
R2420 T9905 T9860 parataxis 3C,used
R2421 T9906 T9905 compound Fig.,3C
R2422 T9907 T9905 punct ),3C
R2423 T9908 T9860 punct .,used
R2424 T9910 T9911 det The,results
R2425 T9911 T9912 nsubj results,revealed
R2426 T9913 T9914 mark that,downregulated
R2427 T9914 T9912 ccomp downregulated,revealed
R2428 T9915 T9916 compound mr,s
R2429 T9916 T9918 compound s,transcription
R2430 T9917 T9916 punct -,s
R2431 T9918 T9914 nsubjpass transcription,downregulated
R2432 T9919 T9914 auxpass was,downregulated
R2433 T9920 T9914 advmod significantly,downregulated
R2434 T9921 T9914 prep in,downregulated
R2435 T9922 T9923 det the,gland
R2436 T9923 T9921 pobj gland,in
R2437 T9924 T9925 nmod Crx,KO
R2438 T9925 T9923 nmod KO,gland
R2439 T9926 T9923 amod pineal,gland
R2440 T9927 T9912 punct .,revealed
R2441 T9929 T9930 advcl Taken,indicate
R2442 T9931 T9929 advmod together,Taken
R2443 T9932 T9930 punct ", ",indicate
R2444 T9933 T9934 det these,data
R2445 T9934 T9930 nsubj data,indicate
R2446 T9935 T9936 mark that,regulated
R2447 T9936 T9930 ccomp regulated,indicate
R2448 T9937 T9938 compound mr,s
R2449 T9938 T9940 compound s,transcription
R2450 T9939 T9938 punct -,s
R2451 T9940 T9936 nsubjpass transcription,regulated
R2452 T9941 T9936 auxpass is,regulated
R2453 T9942 T9936 agent by,regulated
R2454 T9943 T9942 pobj Crx,by
R2455 T9944 T9936 prep in,regulated
R2456 T9945 T9946 det the,photoreceptors
R2457 T9946 T9944 pobj photoreceptors,in
R2458 T9947 T9946 amod developing,photoreceptors
R2459 T9948 T9946 cc and,photoreceptors
R2460 T9949 T9950 amod pineal,gland
R2461 T9950 T9946 conj gland,photoreceptors
R2462 T9951 T9930 punct .,indicate