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PMC:1435744 / 131-2235 JSONTXT 4 Projects

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Id Subject Object Predicate Lexical cue
T1025 0-10 sentence denotes Background
T1026 0-10 NN denotes Background
T1027 10-136 sentence denotes Sterile alpha motif (SAM) domains are ~70 residues long and have been reported as common protein-protein interaction modules.
T1028 11-18 JJ denotes Sterile
T1030 19-24 NN denotes alpha
T1029 25-30 NN denotes motif
T1032 31-32 -LRB- denotes (
T1033 32-35 NN denotes SAM
T1034 35-36 -RRB- denotes )
T1031 37-44 NNS denotes domains
T1035 45-48 VBP denotes are
T1036 49-50 SYM denotes ~
T1037 50-52 CD denotes 70
T1038 53-61 NNS denotes residues
T1039 62-66 JJ denotes long
T1040 67-70 CC denotes and
T1041 71-75 VBP denotes have
T1043 76-80 VBN denotes been
T1042 81-89 VBN denotes reported
T1044 90-92 IN denotes as
T1045 93-99 JJ denotes common
T1047 100-107 NN denotes protein
T1049 107-108 HYPH denotes -
T1048 108-115 NN denotes protein
T1050 116-127 NN denotes interaction
T1046 128-135 NNS denotes modules
T1051 135-136 . denotes .
T1052 136-266 sentence denotes This domain is found in a large number of proteins, including Polycomb group (PcG) proteins and ETS family transcription factors.
T1053 137-141 DT denotes This
T1054 142-148 NN denotes domain
T1056 149-151 VBZ denotes is
T1055 152-157 VBN denotes found
T1057 158-160 IN denotes in
T1058 161-162 DT denotes a
T1060 163-168 JJ denotes large
T1059 169-175 NN denotes number
T1061 176-178 IN denotes of
T1062 179-187 NN denotes proteins
T1063 187-189 , denotes ,
T1064 189-198 VBG denotes including
T1065 199-207 NN denotes Polycomb
T1066 208-213 NN denotes group
T1068 214-215 -LRB- denotes (
T1069 215-218 NN denotes PcG
T1070 218-219 -RRB- denotes )
T1067 220-228 NN denotes proteins
T1071 229-232 CC denotes and
T1072 233-236 NN denotes ETS
T1073 237-243 NN denotes family
T1075 244-257 NN denotes transcription
T1074 258-265 NNS denotes factors
T1076 265-266 . denotes .
T1077 266-521 sentence denotes In this work, we report the cloning and functional characterization of a novel SAM domain-containing protein, which is predominantly expressed in retinal photoreceptors and the pineal gland and is designated mouse mr-s (major retinal SAM domain protein).
T1078 267-269 IN denotes In
T1080 270-274 DT denotes this
T1081 275-279 NN denotes work
T1082 279-281 , denotes ,
T1083 281-283 PRP denotes we
T1079 284-290 VBP denotes report
T1084 291-294 DT denotes the
T1085 295-302 NN denotes cloning
T1086 303-306 CC denotes and
T1087 307-317 JJ denotes functional
T1088 318-334 NN denotes characterization
T1089 335-337 IN denotes of
T1090 338-339 DT denotes a
T1092 340-345 JJ denotes novel
T1093 346-349 NN denotes SAM
T1094 350-356 NN denotes domain
T1096 356-357 HYPH denotes -
T1095 357-367 VBG denotes containing
T1091 368-375 NN denotes protein
T1097 375-377 , denotes ,
T1098 377-382 WDT denotes which
T1100 383-385 VBZ denotes is
T1101 386-399 RB denotes predominantly
T1099 400-409 VBN denotes expressed
T1102 410-412 IN denotes in
T1103 413-420 JJ denotes retinal
T1104 421-435 NNS denotes photoreceptors
T1105 436-439 CC denotes and
T1106 440-443 DT denotes the
T1108 444-450 JJ denotes pineal
T1107 451-456 NN denotes gland
T1109 457-460 CC denotes and
T1110 461-463 VBZ denotes is
T1111 464-474 VBN denotes designated
T1112 475-480 NN denotes mouse
T1114 481-483 NN denotes mr
T1115 483-484 HYPH denotes -
T1113 484-485 NN denotes s
T1116 486-487 -LRB- denotes (
T1118 487-492 JJ denotes major
T1119 493-500 JJ denotes retinal
T1120 501-504 NN denotes SAM
T1121 505-511 NN denotes domain
T1117 512-519 NN denotes protein
T1122 519-520 -RRB- denotes )
T1123 520-521 . denotes .
T1124 521-530 sentence denotes Results
T1125 523-530 NNS denotes Results
T1126 530-686 sentence denotes mr-s is evolutionarily conserved from zebrafish through human, organisms through which the mechanism of photoreceptor development is also highly conserved.
T1127 531-533 NN denotes mr
T1129 533-534 HYPH denotes -
T1128 534-535 NN denotes s
T1131 536-538 VBZ denotes is
T1132 539-553 RB denotes evolutionarily
T1130 554-563 VBN denotes conserved
T1133 564-568 IN denotes from
T1134 569-578 NN denotes zebrafish
T1135 579-586 IN denotes through
T1136 587-592 JJ denotes human
T1137 592-594 , denotes ,
T1138 594-603 NNS denotes organisms
T1139 604-611 IN denotes through
T1141 612-617 WDT denotes which
T1142 618-621 DT denotes the
T1143 622-631 NN denotes mechanism
T1144 632-634 IN denotes of
T1145 635-648 NN denotes photoreceptor
T1146 649-660 NN denotes development
T1147 661-663 VBZ denotes is
T1148 664-668 RB denotes also
T1149 669-675 RB denotes highly
T1140 676-685 VBN denotes conserved
T1150 685-686 . denotes .
T1151 686-898 sentence denotes Phylogenetic analysis suggests that the SAM domain of mr-s is most closely related to a mouse polyhomeotic (ph) ortholog, Mph1/Rae28, which is known as an epigenetic molecule involved in chromatin modifications.
T1152 687-699 JJ denotes Phylogenetic
T1153 700-708 NN denotes analysis
T1154 709-717 VBZ denotes suggests
T1155 718-722 IN denotes that
T1157 723-726 DT denotes the
T1159 727-730 NN denotes SAM
T1158 731-737 NN denotes domain
T1160 738-740 IN denotes of
T1161 741-743 NN denotes mr
T1163 743-744 HYPH denotes -
T1162 744-745 NN denotes s
T1164 746-748 VBZ denotes is
T1165 749-753 RBS denotes most
T1166 754-761 RB denotes closely
T1156 762-769 VBN denotes related
T1167 770-772 IN denotes to
T1168 773-774 DT denotes a
T1170 775-780 NN denotes mouse
T1171 781-793 NN denotes polyhomeotic
T1172 794-795 -LRB- denotes (
T1173 795-797 NN denotes ph
T1174 797-798 -RRB- denotes )
T1169 799-807 NN denotes ortholog
T1175 807-809 , denotes ,
T1176 809-813 NN denotes Mph1
T1178 813-814 HYPH denotes /
T1177 814-819 NN denotes Rae28
T1179 819-821 , denotes ,
T1180 821-826 WDT denotes which
T1182 827-829 VBZ denotes is
T1181 830-835 VBN denotes known
T1183 836-838 IN denotes as
T1184 839-841 DT denotes an
T1186 842-852 JJ denotes epigenetic
T1185 853-861 NN denotes molecule
T1187 862-870 VBN denotes involved
T1188 871-873 IN denotes in
T1189 874-883 NN denotes chromatin
T1190 884-897 NNS denotes modifications
T1191 897-898 . denotes .
T1192 898-1032 sentence denotes These findings provide the possibility that mr-s may play a critical role by regulating gene expression in photoreceptor development.
T1193 899-904 DT denotes These
T1194 905-913 NNS denotes findings
T1195 914-921 VBP denotes provide
T1196 922-925 DT denotes the
T1197 926-937 NN denotes possibility
T1198 938-942 IN denotes that
T1200 943-945 NN denotes mr
T1202 945-946 HYPH denotes -
T1201 946-947 NN denotes s
T1203 948-951 MD denotes may
T1199 952-956 VB denotes play
T1204 957-958 DT denotes a
T1206 959-967 JJ denotes critical
T1205 968-972 NN denotes role
T1207 973-975 IN denotes by
T1208 976-986 VBG denotes regulating
T1209 987-991 NN denotes gene
T1210 992-1002 NN denotes expression
T1211 1003-1005 IN denotes in
T1212 1006-1019 NN denotes photoreceptor
T1213 1020-1031 NN denotes development
T1214 1031-1032 . denotes .
T1215 1032-1201 sentence denotes mr-s is preferentially expressed in the photoreceptors at postnatal day 3–6 (P3-6), when photoreceptors undergo terminal differentiation, and in the adult pineal gland.
T1216 1033-1035 NN denotes mr
T1218 1035-1036 HYPH denotes -
T1217 1036-1037 NN denotes s
T1220 1038-1040 VBZ denotes is
T1221 1041-1055 RB denotes preferentially
T1219 1056-1065 VBN denotes expressed
T1222 1066-1068 IN denotes in
T1223 1069-1072 DT denotes the
T1224 1073-1087 NNS denotes photoreceptors
T1225 1088-1090 IN denotes at
T1226 1091-1100 JJ denotes postnatal
T1228 1101-1104 NN denotes day
T1227 1105-1106 CD denotes 3
T1229 1106-1107 SYM denotes –
T1230 1107-1108 CD denotes 6
T1231 1109-1110 -LRB- denotes (
T1232 1110-1112 NN denotes P3
T1233 1112-1113 SYM denotes -
T1234 1113-1114 CD denotes 6
T1235 1114-1115 -RRB- denotes )
T1236 1115-1117 , denotes ,
T1237 1117-1121 WRB denotes when
T1239 1122-1136 NNS denotes photoreceptors
T1238 1137-1144 VBP denotes undergo
T1240 1145-1153 JJ denotes terminal
T1241 1154-1169 NN denotes differentiation
T1242 1169-1171 , denotes ,
T1243 1171-1174 CC denotes and
T1244 1175-1177 IN denotes in
T1245 1178-1181 DT denotes the
T1247 1182-1187 JJ denotes adult
T1248 1188-1194 JJ denotes pineal
T1246 1195-1200 NN denotes gland
T1249 1200-1201 . denotes .
T1250 1201-1286 sentence denotes Transcription of mr-s is directly regulated by the cone-rod homeodomain protein Crx.
T1251 1202-1215 NN denotes Transcription
T1253 1216-1218 IN denotes of
T1254 1219-1221 NN denotes mr
T1256 1221-1222 HYPH denotes -
T1255 1222-1223 NN denotes s
T1257 1224-1226 VBZ denotes is
T1258 1227-1235 RB denotes directly
T1252 1236-1245 VBN denotes regulated
T1259 1246-1248 IN denotes by
T1260 1249-1252 DT denotes the
T1262 1253-1257 NN denotes cone
T1264 1257-1258 HYPH denotes -
T1263 1258-1261 NN denotes rod
T1265 1262-1273 NN denotes homeodomain
T1261 1274-1281 NN denotes protein
T1266 1282-1285 NN denotes Crx
T1267 1285-1286 . denotes .
T1268 1286-1420 sentence denotes Immunoprecipitation assay showed that the mr-s protein self-associates mainly through the SAM domain-containing region as well as ph.
T1269 1287-1306 NN denotes Immunoprecipitation
T1270 1307-1312 NN denotes assay
T1271 1313-1319 VBD denotes showed
T1272 1320-1324 IN denotes that
T1274 1325-1328 DT denotes the
T1276 1329-1331 NN denotes mr
T1278 1331-1332 HYPH denotes -
T1277 1332-1333 NN denotes s
T1275 1334-1341 NN denotes protein
T1279 1342-1346 NN denotes self
T1280 1346-1347 HYPH denotes -
T1273 1347-1357 VBZ denotes associates
T1281 1358-1364 RB denotes mainly
T1282 1365-1372 IN denotes through
T1283 1373-1376 DT denotes the
T1285 1377-1380 NN denotes SAM
T1286 1381-1387 NN denotes domain
T1288 1387-1388 HYPH denotes -
T1287 1388-1398 VBG denotes containing
T1284 1399-1405 NN denotes region
T1289 1406-1408 RB denotes as
T1291 1409-1413 RB denotes well
T1290 1414-1416 IN denotes as
T1292 1417-1419 NN denotes ph
T1293 1419-1420 . denotes .
T1294 1420-1515 sentence denotes The mr-s protein localizes mainly in the nucleus, when mr-s is overexpressed in HEK293T cells.
T1295 1421-1424 DT denotes The
T1297 1425-1427 NN denotes mr
T1299 1427-1428 HYPH denotes -
T1298 1428-1429 NN denotes s
T1296 1430-1437 NN denotes protein
T1300 1438-1447 VBZ denotes localizes
T1301 1448-1454 RB denotes mainly
T1302 1455-1457 IN denotes in
T1303 1458-1461 DT denotes the
T1304 1462-1469 NN denotes nucleus
T1305 1469-1471 , denotes ,
T1306 1471-1475 WRB denotes when
T1308 1476-1478 NN denotes mr
T1310 1478-1479 HYPH denotes -
T1309 1479-1480 NN denotes s
T1311 1481-1483 VBZ denotes is
T1307 1484-1497 VBN denotes overexpressed
T1312 1498-1500 IN denotes in
T1313 1501-1508 NN denotes HEK293T
T1314 1509-1514 NNS denotes cells
T1315 1514-1515 . denotes .
T1316 1515-1653 sentence denotes Moreover, in the luciferase assays, we found that mr-s protein fused to GAL4 DNA-binding domain functions as a transcriptional repressor.
T1317 1516-1524 RB denotes Moreover
T1319 1524-1526 , denotes ,
T1320 1526-1528 IN denotes in
T1321 1529-1532 DT denotes the
T1323 1533-1543 NN denotes luciferase
T1322 1544-1550 NNS denotes assays
T1324 1550-1552 , denotes ,
T1325 1552-1554 PRP denotes we
T1318 1555-1560 VBD denotes found
T1326 1561-1565 IN denotes that
T1328 1566-1568 NN denotes mr
T1330 1568-1569 HYPH denotes -
T1329 1569-1570 NN denotes s
T1331 1571-1578 NN denotes protein
T1332 1579-1584 VBN denotes fused
T1333 1585-1587 IN denotes to
T1334 1588-1592 NN denotes GAL4
T1336 1593-1596 NN denotes DNA
T1338 1596-1597 HYPH denotes -
T1337 1597-1604 VBG denotes binding
T1335 1605-1611 NN denotes domain
T1327 1612-1621 VBZ denotes functions
T1339 1622-1624 IN denotes as
T1340 1625-1626 DT denotes a
T1342 1627-1642 JJ denotes transcriptional
T1341 1643-1652 NN denotes repressor
T1343 1652-1653 . denotes .
T1344 1653-1794 sentence denotes We revealed that the repression activity of mr-s is not due to a homophilic interaction through its SAM domain but to the C-terminal region.
T1345 1654-1656 PRP denotes We
T1346 1657-1665 VBD denotes revealed
T1347 1666-1670 IN denotes that
T1349 1671-1674 DT denotes the
T1351 1675-1685 NN denotes repression
T1350 1686-1694 NN denotes activity
T1352 1695-1697 IN denotes of
T1353 1698-1700 NN denotes mr
T1355 1700-1701 HYPH denotes -
T1354 1701-1702 NN denotes s
T1348 1703-1705 VBZ denotes is
T1356 1706-1709 RB denotes not
T1357 1710-1713 IN denotes due
T1358 1714-1716 IN denotes to
T1359 1717-1718 DT denotes a
T1361 1719-1729 JJ denotes homophilic
T1360 1730-1741 NN denotes interaction
T1362 1742-1749 IN denotes through
T1363 1750-1753 PRP$ denotes its
T1365 1754-1757 NN denotes SAM
T1364 1758-1764 NN denotes domain
T1366 1765-1768 CC denotes but
T1367 1769-1771 IN denotes to
T1368 1772-1775 DT denotes the
T1370 1776-1777 NN denotes C
T1372 1777-1778 HYPH denotes -
T1371 1778-1786 JJ denotes terminal
T1369 1787-1793 NN denotes region
T1373 1793-1794 . denotes .
T1374 1794-1806 sentence denotes Conclusion
T1375 1796-1806 NN denotes Conclusion
T1376 1806-1917 sentence denotes We identified a novel gene, mr-s, which is predominantly expressed in retinal photoreceptors and pineal gland.
T1377 1807-1809 PRP denotes We
T1378 1810-1820 VBD denotes identified
T1379 1821-1822 DT denotes a
T1381 1823-1828 JJ denotes novel
T1380 1829-1833 NN denotes gene
T1382 1833-1835 , denotes ,
T1383 1835-1837 NN denotes mr
T1385 1837-1838 HYPH denotes -
T1384 1838-1839 NN denotes s
T1386 1839-1841 , denotes ,
T1387 1841-1846 WDT denotes which
T1389 1847-1849 VBZ denotes is
T1390 1850-1863 RB denotes predominantly
T1388 1864-1873 VBN denotes expressed
T1391 1874-1876 IN denotes in
T1392 1877-1884 JJ denotes retinal
T1393 1885-1899 NNS denotes photoreceptors
T1394 1900-1903 CC denotes and
T1395 1904-1910 JJ denotes pineal
T1396 1911-1916 NN denotes gland
T1397 1916-1917 . denotes .
T1398 1917-2104 sentence denotes Based on its expression pattern and biochemical analysis, we predict that mr-s may function as a transcriptional repressor in photoreceptor cells and in pinealocytes of the pineal gland.
T1399 1918-1923 VBN denotes Based
T1401 1924-1926 IN denotes on
T1402 1927-1930 PRP$ denotes its
T1404 1931-1941 NN denotes expression
T1403 1942-1949 NN denotes pattern
T1405 1950-1953 CC denotes and
T1406 1954-1965 JJ denotes biochemical
T1407 1966-1974 NN denotes analysis
T1408 1974-1976 , denotes ,
T1409 1976-1978 PRP denotes we
T1400 1979-1986 VBP denotes predict
T1410 1987-1991 IN denotes that
T1412 1992-1994 NN denotes mr
T1414 1994-1995 HYPH denotes -
T1413 1995-1996 NN denotes s
T1415 1997-2000 MD denotes may
T1411 2001-2009 VB denotes function
T1416 2010-2012 IN denotes as
T1417 2013-2014 DT denotes a
T1419 2015-2030 JJ denotes transcriptional
T1418 2031-2040 NN denotes repressor
T1420 2041-2043 IN denotes in
T1421 2044-2057 NN denotes photoreceptor
T1422 2058-2063 NNS denotes cells
T1423 2064-2067 CC denotes and
T1424 2068-2070 IN denotes in
T1425 2071-2083 NNS denotes pinealocytes
T1426 2084-2086 IN denotes of
T1427 2087-2090 DT denotes the
T1429 2091-2097 JJ denotes pineal
T1428 2098-2103 NN denotes gland
T1430 2103-2104 . denotes .
R100 T1113 T1111 oprd s,designated
R101 T1114 T1113 compound mr,s
R102 T1115 T1113 punct -,s
R103 T1116 T1117 punct (,protein
R104 T1117 T1113 parataxis protein,s
R105 T1118 T1117 amod major,protein
R106 T1119 T1117 amod retinal,protein
R107 T1120 T1121 compound SAM,domain
R108 T1121 T1117 compound domain,protein
R109 T1122 T1117 punct ),protein
R110 T1123 T1079 punct .,report
R111 T1127 T1128 compound mr,s
R112 T1128 T1130 nsubjpass s,conserved
R113 T1129 T1128 punct -,s
R114 T1131 T1130 auxpass is,conserved
R115 T1132 T1130 advmod evolutionarily,conserved
R116 T1133 T1130 prep from,conserved
R117 T1134 T1133 pobj zebrafish,from
R118 T1135 T1133 prep through,from
R119 T1136 T1135 pobj human,through
R120 T1137 T1130 punct ", ",conserved
R121 T1138 T1130 npadvmod organisms,conserved
R122 T1139 T1140 prep through,conserved
R123 T1140 T1138 relcl conserved,organisms
R124 T1141 T1139 pobj which,through
R125 T1142 T1143 det the,mechanism
R126 T1143 T1140 nsubjpass mechanism,conserved
R127 T1144 T1143 prep of,mechanism
R128 T1145 T1146 compound photoreceptor,development
R129 T1146 T1144 pobj development,of
R130 T1147 T1140 auxpass is,conserved
R131 T1148 T1140 advmod also,conserved
R132 T1149 T1140 advmod highly,conserved
R133 T1150 T1130 punct .,conserved
R134 T1152 T1153 amod Phylogenetic,analysis
R135 T1153 T1154 nsubj analysis,suggests
R136 T1155 T1156 mark that,related
R137 T1156 T1154 ccomp related,suggests
R138 T1157 T1158 det the,domain
R139 T1158 T1156 nsubjpass domain,related
R140 T1159 T1158 compound SAM,domain
R141 T1160 T1158 prep of,domain
R142 T1161 T1162 compound mr,s
R143 T1162 T1160 pobj s,of
R144 T1163 T1162 punct -,s
R145 T1164 T1156 auxpass is,related
R146 T1165 T1166 advmod most,closely
R147 T1166 T1156 advmod closely,related
R148 T1167 T1156 prep to,related
R149 T1168 T1169 det a,ortholog
R150 T1169 T1167 pobj ortholog,to
R151 T1170 T1169 nmod mouse,ortholog
R152 T1171 T1169 nmod polyhomeotic,ortholog
R153 T1172 T1173 punct (,ph
R154 T1173 T1171 parataxis ph,polyhomeotic
R155 T1174 T1173 punct ),ph
R156 T1175 T1169 punct ", ",ortholog
R157 T1176 T1177 compound Mph1,Rae28
R158 T1177 T1169 appos Rae28,ortholog
R159 T1178 T1177 punct /,Rae28
R160 T1179 T1169 punct ", ",ortholog
R161 T1180 T1181 dep which,known
R162 T1181 T1169 relcl known,ortholog
R163 T1182 T1181 auxpass is,known
R164 T1183 T1181 prep as,known
R165 T1184 T1185 det an,molecule
R166 T1185 T1183 pobj molecule,as
R167 T1186 T1185 amod epigenetic,molecule
R168 T1187 T1185 acl involved,molecule
R169 T1188 T1187 prep in,involved
R170 T1189 T1190 compound chromatin,modifications
R171 T1190 T1188 pobj modifications,in
R172 T1191 T1154 punct .,suggests
R173 T1193 T1194 det These,findings
R174 T1194 T1195 nsubj findings,provide
R175 T1196 T1197 det the,possibility
R176 T1197 T1195 dobj possibility,provide
R177 T1198 T1199 mark that,play
R178 T1199 T1197 acl play,possibility
R179 T1200 T1201 compound mr,s
R180 T1201 T1199 nsubj s,play
R181 T1202 T1201 punct -,s
R182 T1203 T1199 aux may,play
R183 T1204 T1205 det a,role
R184 T1205 T1199 dobj role,play
R185 T1206 T1205 amod critical,role
R186 T1207 T1199 prep by,play
R187 T1208 T1207 pcomp regulating,by
R188 T1209 T1210 compound gene,expression
R189 T1210 T1208 dobj expression,regulating
R190 T1211 T1208 prep in,regulating
R191 T1212 T1213 compound photoreceptor,development
R192 T1213 T1211 pobj development,in
R193 T1214 T1195 punct .,provide
R194 T1216 T1217 compound mr,s
R195 T1217 T1219 nsubjpass s,expressed
R196 T1218 T1217 punct -,s
R197 T1220 T1219 auxpass is,expressed
R198 T1221 T1219 advmod preferentially,expressed
R199 T1222 T1219 prep in,expressed
R20 T1028 T1029 amod Sterile,motif
R200 T1223 T1224 det the,photoreceptors
R201 T1224 T1222 pobj photoreceptors,in
R202 T1225 T1219 prep at,expressed
R203 T1226 T1227 amod postnatal,3
R204 T1227 T1225 pobj 3,at
R205 T1228 T1227 nmod day,3
R206 T1229 T1230 punct –,6
R207 T1230 T1227 prep 6,3
R208 T1231 T1232 punct (,P3
R209 T1232 T1227 parataxis P3,3
R21 T1029 T1031 nmod motif,domains
R210 T1233 T1234 punct -,6
R211 T1234 T1232 prep 6,P3
R212 T1235 T1232 punct ),P3
R213 T1236 T1227 punct ", ",3
R214 T1237 T1238 advmod when,undergo
R215 T1238 T1227 advcl undergo,3
R216 T1239 T1238 nsubj photoreceptors,undergo
R217 T1240 T1241 amod terminal,differentiation
R218 T1241 T1238 dobj differentiation,undergo
R219 T1242 T1219 punct ", ",expressed
R22 T1030 T1029 nmod alpha,motif
R220 T1243 T1244 cc and,in
R221 T1244 T1219 prep in,expressed
R222 T1245 T1246 det the,gland
R223 T1246 T1244 pobj gland,in
R224 T1247 T1246 amod adult,gland
R225 T1248 T1246 amod pineal,gland
R226 T1249 T1219 punct .,expressed
R227 T1251 T1252 nsubjpass Transcription,regulated
R228 T1253 T1251 prep of,Transcription
R229 T1254 T1255 compound mr,s
R23 T1031 T1035 nsubj domains,are
R230 T1255 T1253 pobj s,of
R231 T1256 T1255 punct -,s
R232 T1257 T1252 auxpass is,regulated
R233 T1258 T1252 advmod directly,regulated
R234 T1259 T1252 agent by,regulated
R235 T1260 T1261 det the,protein
R236 T1261 T1259 pobj protein,by
R237 T1262 T1263 compound cone,rod
R238 T1263 T1261 compound rod,protein
R239 T1264 T1263 punct -,rod
R24 T1032 T1029 punct (,motif
R240 T1265 T1261 compound homeodomain,protein
R241 T1266 T1261 appos Crx,protein
R242 T1267 T1252 punct .,regulated
R243 T1269 T1270 compound Immunoprecipitation,assay
R244 T1270 T1271 nsubj assay,showed
R245 T1272 T1273 mark that,associates
R246 T1273 T1271 ccomp associates,showed
R247 T1274 T1275 det the,protein
R248 T1275 T1273 nsubj protein,associates
R249 T1276 T1277 compound mr,s
R25 T1033 T1029 appos SAM,motif
R250 T1277 T1275 compound s,protein
R251 T1278 T1277 punct -,s
R252 T1279 T1273 dep self,associates
R253 T1280 T1273 punct -,associates
R254 T1281 T1282 advmod mainly,through
R255 T1282 T1273 prep through,associates
R256 T1283 T1284 det the,region
R257 T1284 T1282 pobj region,through
R258 T1285 T1286 compound SAM,domain
R259 T1286 T1287 npadvmod domain,containing
R26 T1034 T1031 punct ),domains
R260 T1287 T1284 amod containing,region
R261 T1288 T1287 punct -,containing
R262 T1289 T1290 advmod as,as
R263 T1290 T1284 cc as,region
R264 T1291 T1290 advmod well,as
R265 T1292 T1284 conj ph,region
R266 T1293 T1271 punct .,showed
R267 T1295 T1296 det The,protein
R268 T1296 T1300 nsubj protein,localizes
R269 T1297 T1298 compound mr,s
R27 T1036 T1037 punct ~,70
R270 T1298 T1296 compound s,protein
R271 T1299 T1298 punct -,s
R272 T1301 T1302 advmod mainly,in
R273 T1302 T1300 prep in,localizes
R274 T1303 T1304 det the,nucleus
R275 T1304 T1302 pobj nucleus,in
R276 T1305 T1300 punct ", ",localizes
R277 T1306 T1307 advmod when,overexpressed
R278 T1307 T1300 advcl overexpressed,localizes
R279 T1308 T1309 compound mr,s
R28 T1037 T1038 nummod 70,residues
R280 T1309 T1307 nsubjpass s,overexpressed
R281 T1310 T1309 punct -,s
R282 T1311 T1307 auxpass is,overexpressed
R283 T1312 T1307 prep in,overexpressed
R284 T1313 T1314 compound HEK293T,cells
R285 T1314 T1312 pobj cells,in
R286 T1315 T1300 punct .,localizes
R287 T1317 T1318 advmod Moreover,found
R288 T1319 T1318 punct ", ",found
R289 T1320 T1318 prep in,found
R29 T1038 T1039 npadvmod residues,long
R290 T1321 T1322 det the,assays
R291 T1322 T1320 pobj assays,in
R292 T1323 T1322 compound luciferase,assays
R293 T1324 T1318 punct ", ",found
R294 T1325 T1318 nsubj we,found
R295 T1326 T1327 mark that,functions
R296 T1327 T1318 ccomp functions,found
R297 T1328 T1329 compound mr,s
R298 T1329 T1331 compound s,protein
R299 T1330 T1329 punct -,s
R30 T1039 T1035 acomp long,are
R300 T1331 T1327 nsubj protein,functions
R301 T1332 T1331 acl fused,protein
R302 T1333 T1332 prep to,fused
R303 T1334 T1335 nmod GAL4,domain
R304 T1335 T1333 pobj domain,to
R305 T1336 T1337 npadvmod DNA,binding
R306 T1337 T1335 amod binding,domain
R307 T1338 T1337 punct -,binding
R308 T1339 T1327 prep as,functions
R309 T1340 T1341 det a,repressor
R31 T1040 T1035 cc and,are
R310 T1341 T1339 pobj repressor,as
R311 T1342 T1341 amod transcriptional,repressor
R312 T1343 T1318 punct .,found
R313 T1345 T1346 nsubj We,revealed
R314 T1347 T1348 mark that,is
R315 T1348 T1346 ccomp is,revealed
R316 T1349 T1350 det the,activity
R317 T1350 T1348 nsubj activity,is
R318 T1351 T1350 compound repression,activity
R319 T1352 T1350 prep of,activity
R32 T1041 T1042 aux have,reported
R320 T1353 T1354 compound mr,s
R321 T1354 T1352 pobj s,of
R322 T1355 T1354 punct -,s
R323 T1356 T1348 neg not,is
R324 T1357 T1348 prep due,is
R325 T1358 T1357 prep to,due
R326 T1359 T1360 det a,interaction
R327 T1360 T1358 pobj interaction,to
R328 T1361 T1360 amod homophilic,interaction
R329 T1362 T1360 prep through,interaction
R33 T1042 T1035 conj reported,are
R330 T1363 T1364 poss its,domain
R331 T1364 T1362 pobj domain,through
R332 T1365 T1364 compound SAM,domain
R333 T1366 T1358 cc but,to
R334 T1367 T1358 conj to,to
R335 T1368 T1369 det the,region
R336 T1369 T1367 pobj region,to
R337 T1370 T1371 npadvmod C,terminal
R338 T1371 T1369 amod terminal,region
R339 T1372 T1371 punct -,terminal
R34 T1043 T1042 auxpass been,reported
R340 T1373 T1346 punct .,revealed
R341 T1377 T1378 nsubj We,identified
R342 T1379 T1380 det a,gene
R343 T1380 T1378 dobj gene,identified
R344 T1381 T1380 amod novel,gene
R345 T1382 T1380 punct ", ",gene
R346 T1383 T1384 compound mr,s
R347 T1384 T1380 appos s,gene
R348 T1385 T1384 punct -,s
R349 T1386 T1380 punct ", ",gene
R35 T1044 T1042 prep as,reported
R350 T1387 T1388 dep which,expressed
R351 T1388 T1380 relcl expressed,gene
R352 T1389 T1388 auxpass is,expressed
R353 T1390 T1388 advmod predominantly,expressed
R354 T1391 T1388 prep in,expressed
R355 T1392 T1393 amod retinal,photoreceptors
R356 T1393 T1391 pobj photoreceptors,in
R357 T1394 T1393 cc and,photoreceptors
R358 T1395 T1396 amod pineal,gland
R359 T1396 T1393 conj gland,photoreceptors
R36 T1045 T1046 amod common,modules
R360 T1397 T1378 punct .,identified
R361 T1399 T1400 prep Based,predict
R362 T1401 T1399 prep on,Based
R363 T1402 T1403 poss its,pattern
R364 T1403 T1401 pobj pattern,on
R365 T1404 T1403 compound expression,pattern
R366 T1405 T1403 cc and,pattern
R367 T1406 T1407 amod biochemical,analysis
R368 T1407 T1403 conj analysis,pattern
R369 T1408 T1400 punct ", ",predict
R37 T1046 T1044 pobj modules,as
R370 T1409 T1400 nsubj we,predict
R371 T1410 T1411 mark that,function
R372 T1411 T1400 ccomp function,predict
R373 T1412 T1413 compound mr,s
R374 T1413 T1411 nsubj s,function
R375 T1414 T1413 punct -,s
R376 T1415 T1411 aux may,function
R377 T1416 T1411 prep as,function
R378 T1417 T1418 det a,repressor
R379 T1418 T1416 pobj repressor,as
R38 T1047 T1048 compound protein,protein
R380 T1419 T1418 amod transcriptional,repressor
R381 T1420 T1411 prep in,function
R382 T1421 T1422 compound photoreceptor,cells
R383 T1422 T1420 pobj cells,in
R384 T1423 T1420 cc and,in
R385 T1424 T1420 conj in,in
R386 T1425 T1424 pobj pinealocytes,in
R387 T1426 T1425 prep of,pinealocytes
R388 T1427 T1428 det the,gland
R389 T1428 T1426 pobj gland,of
R39 T1048 T1050 compound protein,interaction
R390 T1429 T1428 amod pineal,gland
R391 T1430 T1400 punct .,predict
R40 T1049 T1048 punct -,protein
R41 T1050 T1046 compound interaction,modules
R42 T1051 T1035 punct .,are
R43 T1053 T1054 det This,domain
R44 T1054 T1055 nsubjpass domain,found
R45 T1056 T1055 auxpass is,found
R46 T1057 T1055 prep in,found
R47 T1058 T1059 det a,number
R48 T1059 T1057 pobj number,in
R49 T1060 T1059 amod large,number
R50 T1061 T1059 prep of,number
R51 T1062 T1061 pobj proteins,of
R52 T1063 T1059 punct ", ",number
R53 T1064 T1059 prep including,number
R54 T1065 T1066 nmod Polycomb,group
R55 T1066 T1067 nmod group,proteins
R56 T1067 T1064 pobj proteins,including
R57 T1068 T1066 punct (,group
R58 T1069 T1066 appos PcG,group
R59 T1070 T1067 punct ),proteins
R60 T1071 T1067 cc and,proteins
R61 T1072 T1073 compound ETS,family
R62 T1073 T1074 compound family,factors
R63 T1074 T1067 conj factors,proteins
R64 T1075 T1074 compound transcription,factors
R65 T1076 T1055 punct .,found
R66 T1078 T1079 prep In,report
R67 T1080 T1081 det this,work
R68 T1081 T1078 pobj work,In
R69 T1082 T1079 punct ", ",report
R70 T1083 T1079 nsubj we,report
R71 T1084 T1085 det the,cloning
R72 T1085 T1079 dobj cloning,report
R73 T1086 T1085 cc and,cloning
R74 T1087 T1088 amod functional,characterization
R75 T1088 T1085 conj characterization,cloning
R76 T1089 T1085 prep of,cloning
R77 T1090 T1091 det a,protein
R78 T1091 T1089 pobj protein,of
R79 T1092 T1091 amod novel,protein
R80 T1093 T1094 compound SAM,domain
R81 T1094 T1095 npadvmod domain,containing
R82 T1095 T1091 amod containing,protein
R83 T1096 T1095 punct -,containing
R84 T1097 T1091 punct ", ",protein
R85 T1098 T1099 dep which,expressed
R86 T1099 T1091 relcl expressed,protein
R87 T1100 T1099 auxpass is,expressed
R88 T1101 T1099 advmod predominantly,expressed
R89 T1102 T1099 prep in,expressed
R90 T1103 T1104 amod retinal,photoreceptors
R91 T1104 T1102 pobj photoreceptors,in
R92 T1105 T1104 cc and,photoreceptors
R93 T1106 T1107 det the,gland
R94 T1107 T1104 conj gland,photoreceptors
R95 T1108 T1107 amod pineal,gland
R96 T1109 T1099 cc and,expressed
R97 T1110 T1111 auxpass is,designated
R98 T1111 T1099 conj designated,expressed
R99 T1112 T1113 compound mouse,s