PMC:1420314 JSON TXT 7 Projects

Annnotations TAB TSV DIC JSON TextAE

Id	Subject	Object	Predicate	Lexical cue
T565	0-8	NNS	denotes	Deficits
T566	0-76	sentence	denotes	Deficits in spatial learning and motor coordination in ADAM11-deficient mice
T567	9-11	IN	denotes	in
T568	12-19	JJ	denotes	spatial
T569	20-28	NN	denotes	learning
T570	29-32	CC	denotes	and
T571	33-38	NN	denotes	motor
T572	39-51	NN	denotes	coordination
T573	52-54	IN	denotes	in
T574	55-61	NN	denotes	ADAM11
T576	61-62	HYPH	denotes	-
T575	62-71	JJ	denotes	deficient
T577	72-76	NNS	denotes	mice
T578	76-77	sentence	denotes
T579	87-97	sentence	denotes	Background
T580	87-97	NN	denotes	Background
T581	97-187	sentence	denotes	ADAM11 is a member of the ADAM gene family and is mainly expressed in the nervous system.
T582	98-104	NN	denotes	ADAM11
T583	105-107	VBZ	denotes	is
T584	108-109	DT	denotes	a
T585	110-116	NN	denotes	member
T586	117-119	IN	denotes	of
T587	120-123	DT	denotes	the
T589	124-128	NN	denotes	ADAM
T590	129-133	NN	denotes	gene
T588	134-140	NN	denotes	family
T591	141-144	CC	denotes	and
T592	145-147	VBZ	denotes	is
T594	148-154	RB	denotes	mainly
T593	155-164	VBN	denotes	expressed
T595	165-167	IN	denotes	in
T596	168-171	DT	denotes	the
T598	172-179	JJ	denotes	nervous
T597	180-186	NN	denotes	system
T599	186-187	.	denotes	.
T600	187-318	sentence	denotes	It is thought to be an adhesion molecule, since it has a disintegrin-like domain related to cell-cell or cell-matrix interactions.
T601	188-190	PRP	denotes	It
T603	191-193	VBZ	denotes	is
T602	194-201	VBN	denotes	thought
T604	202-204	TO	denotes	to
T605	205-207	VB	denotes	be
T606	208-210	DT	denotes	an
T608	211-219	NN	denotes	adhesion
T607	220-228	NN	denotes	molecule
T609	228-230	,	denotes	,
T610	230-235	IN	denotes	since
T612	236-238	PRP	denotes	it
T611	239-242	VBZ	denotes	has
T613	243-244	DT	denotes	a
T615	245-256	NN	denotes	disintegrin
T617	256-257	HYPH	denotes	-
T616	257-261	JJ	denotes	like
T614	262-268	NN	denotes	domain
T618	269-276	VBN	denotes	related
T619	277-279	IN	denotes	to
T620	280-284	NN	denotes	cell
T622	284-285	SYM	denotes	-
T621	285-289	NN	denotes	cell
T624	290-292	CC	denotes	or
T625	293-297	NN	denotes	cell
T627	297-298	SYM	denotes	-
T626	298-304	NN	denotes	matrix
T623	305-317	NNS	denotes	interactions
T628	317-318	.	denotes	.
T629	318-433	sentence	denotes	To elucidate the physiological functions of ADAM11, we generated ADAM11-deficient mice by means of gene targeting.
T630	319-321	TO	denotes	To
T631	322-331	VB	denotes	elucidate
T633	332-335	DT	denotes	the
T635	336-349	JJ	denotes	physiological
T634	350-359	NNS	denotes	functions
T636	360-362	IN	denotes	of
T637	363-369	NN	denotes	ADAM11
T638	369-371	,	denotes	,
T639	371-373	PRP	denotes	we
T632	374-383	VBD	denotes	generated
T640	384-390	NN	denotes	ADAM11
T642	390-391	HYPH	denotes	-
T641	391-400	JJ	denotes	deficient
T643	401-405	NNS	denotes	mice
T644	406-408	IN	denotes	by
T645	409-414	NNS	denotes	means
T646	415-417	IN	denotes	of
T647	418-422	NN	denotes	gene
T648	423-432	NN	denotes	targeting
T649	432-433	.	denotes	.
T650	433-442	sentence	denotes	Results
T651	435-442	NNS	denotes	Results
T652	442-590	sentence	denotes	ADAM11-deficient mice were apparently normal, and survived more than one year with no major histological abnormalities in the brain or spinal cord.
T653	443-449	NN	denotes	ADAM11
T655	449-450	HYPH	denotes	-
T654	450-459	JJ	denotes	deficient
T656	460-464	NNS	denotes	mice
T657	465-469	VBD	denotes	were
T658	470-480	RB	denotes	apparently
T659	481-487	JJ	denotes	normal
T660	487-489	,	denotes	,
T661	489-492	CC	denotes	and
T662	493-501	VBD	denotes	survived
T663	502-506	JJR	denotes	more
T665	507-511	IN	denotes	than
T664	512-515	CD	denotes	one
T666	516-520	NN	denotes	year
T667	521-525	IN	denotes	with
T668	526-528	DT	denotes	no
T670	529-534	JJ	denotes	major
T671	535-547	JJ	denotes	histological
T669	548-561	NNS	denotes	abnormalities
T672	562-564	IN	denotes	in
T673	565-568	DT	denotes	the
T674	569-574	NN	denotes	brain
T675	575-577	CC	denotes	or
T676	578-584	JJ	denotes	spinal
T677	585-589	NN	denotes	cord
T678	589-590	.	denotes	.
T679	590-807	sentence	denotes	Because ADAM11 is highly expressed in the hippocampus and cerebellum, we have examined ADAM11 mutant mice for learning using visual and hidden water maze tasks, and their motor coordination using a rotating rod task.
T680	591-598	IN	denotes	Because
T682	599-605	NN	denotes	ADAM11
T681	606-608	VBZ	denotes	is
T684	609-615	RB	denotes	highly
T685	616-625	VBN	denotes	expressed
T686	626-628	IN	denotes	in
T687	629-632	DT	denotes	the
T688	633-644	NN	denotes	hippocampus
T689	645-648	CC	denotes	and
T690	649-659	NN	denotes	cerebellum
T691	659-661	,	denotes	,
T692	661-663	PRP	denotes	we
T693	664-668	VBP	denotes	have
T683	669-677	VBN	denotes	examined
T694	678-684	NN	denotes	ADAM11
T696	685-691	NN	denotes	mutant
T695	692-696	NNS	denotes	mice
T697	697-700	IN	denotes	for
T698	701-709	VBG	denotes	learning
T699	710-715	VBG	denotes	using
T700	716-722	JJ	denotes	visual
T702	723-726	CC	denotes	and
T703	727-733	JJ	denotes	hidden
T704	734-739	NN	denotes	water
T705	740-744	NN	denotes	maze
T701	745-750	NNS	denotes	tasks
T706	750-752	,	denotes	,
T707	752-755	CC	denotes	and
T708	756-761	PRP$	denotes	their
T710	762-767	JJ	denotes	motor
T709	768-780	NN	denotes	coordination
T711	781-786	VBG	denotes	using
T712	787-788	DT	denotes	a
T714	789-797	VBG	denotes	rotating
T715	798-801	NN	denotes	rod
T713	802-806	NN	denotes	task
T716	806-807	.	denotes	.
T717	807-974	sentence	denotes	Our results showed that their visual water maze task results are normal, but the hidden water maze and rotating rod task skills are impaired in ADAM11-deficient mice.
T718	808-811	PRP$	denotes	Our
T719	812-819	NNS	denotes	results
T720	820-826	VBD	denotes	showed
T721	827-831	IN	denotes	that
T723	832-837	PRP$	denotes	their
T725	838-844	JJ	denotes	visual
T727	845-850	NN	denotes	water
T726	851-855	NN	denotes	maze
T728	856-860	NN	denotes	task
T724	861-868	NNS	denotes	results
T722	869-872	VBP	denotes	are
T729	873-879	JJ	denotes	normal
T730	879-881	,	denotes	,
T731	881-884	CC	denotes	but
T732	885-888	DT	denotes	the
T734	889-895	JJ	denotes	hidden
T736	896-901	NN	denotes	water
T735	902-906	NN	denotes	maze
T738	907-910	CC	denotes	and
T739	911-919	VBG	denotes	rotating
T740	920-923	NN	denotes	rod
T737	924-928	NN	denotes	task
T733	929-935	NNS	denotes	skills
T741	936-939	VBP	denotes	are
T742	940-948	JJ	denotes	impaired
T743	949-951	IN	denotes	in
T744	952-958	NN	denotes	ADAM11
T746	958-959	HYPH	denotes	-
T745	959-968	JJ	denotes	deficient
T747	969-973	NNS	denotes	mice
T748	973-974	.	denotes	.
T749	974-986	sentence	denotes	Conclusion
T750	976-986	NN	denotes	Conclusion
T751	986-1144	sentence	denotes	Our results indicate that ADAM11 mutation does not affect cell migration and differentiation during development, but affects learning and motor coordination.
T752	987-990	PRP$	denotes	Our
T753	991-998	NNS	denotes	results
T754	999-1007	VBP	denotes	indicate
T755	1008-1012	IN	denotes	that
T757	1013-1019	NN	denotes	ADAM11
T758	1020-1028	NN	denotes	mutation
T759	1029-1033	VBZ	denotes	does
T760	1034-1037	RB	denotes	not
T756	1038-1044	VB	denotes	affect
T761	1045-1049	NN	denotes	cell
T762	1050-1059	NN	denotes	migration
T763	1060-1063	CC	denotes	and
T764	1064-1079	NN	denotes	differentiation
T765	1080-1086	IN	denotes	during
T766	1087-1098	NN	denotes	development
T767	1098-1100	,	denotes	,
T768	1100-1103	CC	denotes	but
T769	1104-1111	VBZ	denotes	affects
T770	1112-1120	NN	denotes	learning
T771	1121-1124	CC	denotes	and
T772	1125-1130	NN	denotes	motor
T773	1131-1143	NN	denotes	coordination
T774	1143-1144	.	denotes	.
T775	1144-1335	sentence	denotes	Thus, ADAM11 might play an important signalling or structural role as a cell adhesion molecule at the synapse, and may thus participate in synaptic regulation underlying behavioural changes.
T776	1145-1149	RB	denotes	Thus
T778	1149-1151	,	denotes	,
T779	1151-1157	NN	denotes	ADAM11
T780	1158-1163	MD	denotes	might
T777	1164-1168	VB	denotes	play
T781	1169-1171	DT	denotes	an
T783	1172-1181	JJ	denotes	important
T784	1182-1192	NN	denotes	signalling
T785	1193-1195	CC	denotes	or
T786	1196-1206	JJ	denotes	structural
T782	1207-1211	NN	denotes	role
T787	1212-1214	IN	denotes	as
T788	1215-1216	DT	denotes	a
T790	1217-1221	NN	denotes	cell
T791	1222-1230	NN	denotes	adhesion
T789	1231-1239	NN	denotes	molecule
T792	1240-1242	IN	denotes	at
T793	1243-1246	DT	denotes	the
T794	1247-1254	NN	denotes	synapse
T795	1254-1256	,	denotes	,
T796	1256-1259	CC	denotes	and
T797	1260-1263	MD	denotes	may
T799	1264-1268	RB	denotes	thus
T798	1269-1280	VB	denotes	participate
T800	1281-1283	IN	denotes	in
T801	1284-1292	JJ	denotes	synaptic
T802	1293-1303	NN	denotes	regulation
T803	1304-1314	VBG	denotes	underlying
T804	1315-1326	JJ	denotes	behavioural
T805	1327-1334	NNS	denotes	changes
T806	1334-1335	.	denotes	.
T2208	1348-1351	DT	denotes	The
T2210	1352-1356	NN	denotes	ADAM
T2211	1357-1358	-LRB-	denotes	(
T2212	1358-1359	DT	denotes	A
T2213	1360-1371	NN	denotes	Disintegrin
T2214	1372-1375	CC	denotes	And
T2215	1376-1391	NN	denotes	Metalloprotease
T2216	1391-1392	-RRB-	denotes	)
T2209	1393-1399	NN	denotes	family
T2217	1400-1409	VBZ	denotes	comprises
T2218	1410-1418	NN	denotes	membrane
T2220	1418-1419	HYPH	denotes	-
T2219	1419-1427	VBG	denotes	spanning
T2222	1428-1440	JJ	denotes	multi-domain
T2221	1441-1449	NN	denotes	proteins
T2223	1450-1460	VBG	denotes	containing
T2224	1461-1462	DT	denotes	a
T2226	1463-1480	NN	denotes	metalloproteinase
T2228	1480-1481	HYPH	denotes	-
T2227	1481-1485	JJ	denotes	like
T2225	1486-1492	NN	denotes	domain
T2229	1493-1496	CC	denotes	and
T2230	1497-1498	DT	denotes	a
T2232	1499-1510	NN	denotes	disintegrin
T2234	1510-1511	HYPH	denotes	-
T2233	1511-1515	JJ	denotes	like
T2231	1516-1522	NN	denotes	domain
T2235	1522-1523	.	denotes	.
T2236	1523-1708	sentence	denotes	Approximately half of the ADAMs are catalytically active metalloproteases that shed a broad range of substrates, such as cytokines, growth factors, receptors, adhesion molecules [1,2].
T2237	1524-1537	RB	denotes	Approximately
T2238	1538-1542	NN	denotes	half
T2240	1543-1545	IN	denotes	of
T2241	1546-1549	DT	denotes	the
T2242	1550-1555	NNS	denotes	ADAMs
T2239	1556-1559	VBP	denotes	are
T2243	1560-1573	RB	denotes	catalytically
T2244	1574-1580	JJ	denotes	active
T2245	1581-1597	NNS	denotes	metalloproteases
T2246	1598-1602	WDT	denotes	that
T2247	1603-1607	VBD	denotes	shed
T2248	1608-1609	DT	denotes	a
T2250	1610-1615	JJ	denotes	broad
T2249	1616-1621	NN	denotes	range
T2251	1622-1624	IN	denotes	of
T2252	1625-1635	NNS	denotes	substrates
T2253	1635-1637	,	denotes	,
T2254	1637-1641	JJ	denotes	such
T2255	1642-1644	IN	denotes	as
T2256	1645-1654	NNS	denotes	cytokines
T2257	1654-1656	,	denotes	,
T2258	1656-1662	NN	denotes	growth
T2259	1663-1670	NNS	denotes	factors
T2260	1670-1672	,	denotes	,
T2261	1672-1681	NNS	denotes	receptors
T2262	1681-1683	,	denotes	,
T2263	1683-1691	NN	denotes	adhesion
T2264	1692-1701	NNS	denotes	molecules
T2265	1702-1703	-LRB-	denotes	[
T2267	1703-1704	CD	denotes	1
T2268	1704-1705	,	denotes	,
T2266	1705-1706	CD	denotes	2
T2269	1706-1707	-RRB-	denotes	]
T2270	1707-1708	.	denotes	.
T2271	1708-1797	sentence	denotes	Recent gene-disruption studies in mice have disclosed a physiological role of each ADAM.
T2272	1709-1715	JJ	denotes	Recent
T2274	1716-1720	NN	denotes	gene
T2276	1720-1721	HYPH	denotes	-
T2275	1721-1731	NN	denotes	disruption
T2273	1732-1739	NNS	denotes	studies
T2278	1740-1742	IN	denotes	in
T2279	1743-1747	NNS	denotes	mice
T2280	1748-1752	VBP	denotes	have
T2277	1753-1762	VBN	denotes	disclosed
T2281	1763-1764	DT	denotes	a
T2283	1765-1778	JJ	denotes	physiological
T2282	1779-1783	NN	denotes	role
T2284	1784-1786	IN	denotes	of
T2285	1787-1791	DT	denotes	each
T2286	1792-1796	NN	denotes	ADAM
T2287	1796-1797	.	denotes	.
T2288	1797-1939	sentence	denotes	For example, ADAM10, ADAM17 and ADAM19 are critical for normal development by providing growth signals at the correct times and places [3-6].
T2289	1798-1801	IN	denotes	For
T2291	1802-1809	NN	denotes	example
T2292	1809-1811	,	denotes	,
T2293	1811-1817	NN	denotes	ADAM10
T2294	1817-1819	,	denotes	,
T2295	1819-1825	NN	denotes	ADAM17
T2296	1826-1829	CC	denotes	and
T2297	1830-1836	NN	denotes	ADAM19
T2290	1837-1840	VBP	denotes	are
T2298	1841-1849	JJ	denotes	critical
T2299	1850-1853	IN	denotes	for
T2300	1854-1860	JJ	denotes	normal
T2301	1861-1872	NN	denotes	development
T2302	1873-1875	IN	denotes	by
T2303	1876-1885	VBG	denotes	providing
T2304	1886-1892	NN	denotes	growth
T2305	1893-1900	NNS	denotes	signals
T2306	1901-1903	IN	denotes	at
T2307	1904-1907	DT	denotes	the
T2309	1908-1915	JJ	denotes	correct
T2308	1916-1921	NNS	denotes	times
T2310	1922-1925	CC	denotes	and
T2311	1926-1932	NNS	denotes	places
T2312	1933-1934	-LRB-	denotes	[
T2313	1934-1935	CD	denotes	3
T2314	1935-1936	SYM	denotes	-
T2315	1936-1937	CD	denotes	6
T2316	1937-1938	-RRB-	denotes	]
T2317	1938-1939	.	denotes	.
T2318	1939-2110	sentence	denotes	In contrast, the functions of ADAM8, ADAM9, ADAM12 and ADAM15 are not essential for embryogenesis, suggesting a possible functional redundancy with other protease [7-10].
T2319	1940-1942	IN	denotes	In
T2321	1943-1951	NN	denotes	contrast
T2322	1951-1953	,	denotes	,
T2323	1953-1956	DT	denotes	the
T2324	1957-1966	NNS	denotes	functions
T2325	1967-1969	IN	denotes	of
T2326	1970-1975	NN	denotes	ADAM8
T2327	1975-1977	,	denotes	,
T2328	1977-1982	NN	denotes	ADAM9
T2329	1982-1984	,	denotes	,
T2330	1984-1990	NN	denotes	ADAM12
T2331	1991-1994	CC	denotes	and
T2332	1995-2001	NN	denotes	ADAM15
T2320	2002-2005	VBP	denotes	are
T2333	2006-2009	RB	denotes	not
T2334	2010-2019	JJ	denotes	essential
T2335	2020-2023	IN	denotes	for
T2336	2024-2037	NN	denotes	embryogenesis
T2337	2037-2039	,	denotes	,
T2338	2039-2049	VBG	denotes	suggesting
T2339	2050-2051	DT	denotes	a
T2341	2052-2060	JJ	denotes	possible
T2342	2061-2071	JJ	denotes	functional
T2340	2072-2082	NN	denotes	redundancy
T2343	2083-2087	IN	denotes	with
T2344	2088-2093	JJ	denotes	other
T2345	2094-2102	NN	denotes	protease
T2346	2103-2104	-LRB-	denotes	[
T2347	2104-2105	CD	denotes	7
T2348	2105-2106	SYM	denotes	-
T2349	2106-2108	CD	denotes	10
T2350	2108-2109	-RRB-	denotes	]
T2351	2109-2110	.	denotes	.
T2352	2110-2198	sentence	denotes	The remaining half, which are non-protease-ADAMs, are thought to be adhesion molecules.
T2353	2111-2114	DT	denotes	The
T2355	2115-2124	VBG	denotes	remaining
T2354	2125-2129	NN	denotes	half
T2357	2129-2131	,	denotes	,
T2358	2131-2136	WDT	denotes	which
T2359	2137-2140	VBP	denotes	are
T2360	2141-2153	JJ	denotes	non-protease
T2362	2153-2154	HYPH	denotes	-
T2361	2154-2159	NNS	denotes	ADAMs
T2363	2159-2161	,	denotes	,
T2364	2161-2164	VBP	denotes	are
T2356	2165-2172	VBN	denotes	thought
T2365	2173-2175	TO	denotes	to
T2366	2176-2178	VB	denotes	be
T2367	2179-2187	NN	denotes	adhesion
T2368	2188-2197	NNS	denotes	molecules
T2369	2197-2198	.	denotes	.
T2370	2198-2292	sentence	denotes	More than ten ADAMs have been shown to support integrin-mediated cell adhesion in vitro [11].
T2371	2199-2203	JJR	denotes	More
T2373	2204-2208	IN	denotes	than
T2372	2209-2212	CD	denotes	ten
T2374	2213-2218	NNS	denotes	ADAMs
T2376	2219-2223	VBP	denotes	have
T2377	2224-2228	VBN	denotes	been
T2375	2229-2234	VBN	denotes	shown
T2378	2235-2237	TO	denotes	to
T2379	2238-2245	VB	denotes	support
T2380	2246-2254	NN	denotes	integrin
T2382	2254-2255	HYPH	denotes	-
T2381	2255-2263	VBN	denotes	mediated
T2384	2264-2268	NN	denotes	cell
T2383	2269-2277	NN	denotes	adhesion
T2385	2278-2280	FW	denotes	in
T2386	2281-2286	FW	denotes	vitro
T2387	2287-2288	-LRB-	denotes	[
T2388	2288-2290	CD	denotes	11
T2389	2290-2291	-RRB-	denotes	]
T2390	2291-2292	.	denotes	.
T2391	2292-2441	sentence	denotes	More recently, the finding has been reported that integrin-mediated cell migration of tissue culture cells can be controlled by distinct ADAMs [12].
T2392	2293-2297	RBR	denotes	More
T2393	2298-2306	RB	denotes	recently
T2395	2306-2308	,	denotes	,
T2396	2308-2311	DT	denotes	the
T2397	2312-2319	NN	denotes	finding
T2398	2320-2323	VBZ	denotes	has
T2399	2324-2328	VBN	denotes	been
T2394	2329-2337	VBN	denotes	reported
T2400	2338-2342	IN	denotes	that
T2402	2343-2351	NN	denotes	integrin
T2404	2351-2352	HYPH	denotes	-
T2403	2352-2360	VBN	denotes	mediated
T2406	2361-2365	NN	denotes	cell
T2405	2366-2375	NN	denotes	migration
T2407	2376-2378	IN	denotes	of
T2408	2379-2385	NN	denotes	tissue
T2409	2386-2393	NN	denotes	culture
T2410	2394-2399	NNS	denotes	cells
T2411	2400-2403	MD	denotes	can
T2412	2404-2406	VB	denotes	be
T2401	2407-2417	VBN	denotes	controlled
T2413	2418-2420	IN	denotes	by
T2414	2421-2429	JJ	denotes	distinct
T2415	2430-2435	NNS	denotes	ADAMs
T2416	2436-2437	-LRB-	denotes	[
T2417	2437-2439	CD	denotes	12
T2418	2439-2440	-RRB-	denotes	]
T2419	2440-2441	.	denotes	.
T2420	2441-2573	sentence	denotes	In C. elegans, unc-71 gene coding a non-protease-ADAM protein have been shown to be involved in cell migration events in vivo [13].
T2421	2442-2444	IN	denotes	In
T2423	2445-2447	NNP	denotes	C.
T2424	2448-2455	NNP	denotes	elegans
T2425	2455-2457	,	denotes	,
T2426	2457-2460	NN	denotes	unc
T2428	2460-2461	HYPH	denotes	-
T2429	2461-2463	CD	denotes	71
T2427	2464-2468	NN	denotes	gene
T2430	2469-2475	VBG	denotes	coding
T2431	2476-2477	DT	denotes	a
T2433	2478-2490	JJ	denotes	non-protease
T2434	2490-2491	HYPH	denotes	-
T2435	2491-2495	NN	denotes	ADAM
T2432	2496-2503	NN	denotes	protein
T2436	2504-2508	VBP	denotes	have
T2437	2509-2513	VBN	denotes	been
T2422	2514-2519	VBN	denotes	shown
T2438	2520-2522	TO	denotes	to
T2440	2523-2525	VB	denotes	be
T2439	2526-2534	VBN	denotes	involved
T2441	2535-2537	IN	denotes	in
T2442	2538-2542	NN	denotes	cell
T2443	2543-2552	NN	denotes	migration
T2444	2553-2559	NNS	denotes	events
T2445	2560-2562	FW	denotes	in
T2446	2563-2567	FW	denotes	vivo
T2447	2568-2569	-LRB-	denotes	[
T2448	2569-2571	CD	denotes	13
T2449	2571-2572	-RRB-	denotes	]
T2450	2572-2573	.	denotes	.
T2451	2573-2669	sentence	denotes	However, the physiological roles of mammalian non-protease-ADAMs are poorly understood in vivo.
T2452	2574-2581	RB	denotes	However
T2454	2581-2583	,	denotes	,
T2455	2583-2586	DT	denotes	the
T2457	2587-2600	JJ	denotes	physiological
T2456	2601-2606	NNS	denotes	roles
T2458	2607-2609	IN	denotes	of
T2459	2610-2619	JJ	denotes	mammalian
T2461	2620-2632	JJ	denotes	non-protease
T2462	2632-2633	HYPH	denotes	-
T2460	2633-2638	NNS	denotes	ADAMs
T2453	2639-2642	VBP	denotes	are
T2463	2643-2649	RB	denotes	poorly
T2464	2650-2660	VBN	denotes	understood
T2465	2661-2663	FW	denotes	in
T2466	2664-2668	FW	denotes	vivo
T2467	2668-2669	.	denotes	.
T2468	2669-2834	sentence	denotes	Genetic deletion studies in mice have shown that both Adam2-null and Adam3-null male mutants are infertile and their spermatozoa lack egg-binding abilities [14-16].
T2469	2670-2677	JJ	denotes	Genetic
T2470	2678-2686	NN	denotes	deletion
T2471	2687-2694	NNS	denotes	studies
T2473	2695-2697	IN	denotes	in
T2474	2698-2702	NNS	denotes	mice
T2475	2703-2707	VBP	denotes	have
T2472	2708-2713	VBN	denotes	shown
T2476	2714-2718	IN	denotes	that
T2478	2719-2723	CC	denotes	both
T2480	2724-2729	NN	denotes	Adam2
T2482	2729-2730	HYPH	denotes	-
T2481	2730-2734	JJ	denotes	null
T2483	2735-2738	CC	denotes	and
T2484	2739-2744	NN	denotes	Adam3
T2486	2744-2745	HYPH	denotes	-
T2485	2745-2749	JJ	denotes	null
T2487	2750-2754	JJ	denotes	male
T2479	2755-2762	NNS	denotes	mutants
T2477	2763-2766	VBP	denotes	are
T2488	2767-2776	JJ	denotes	infertile
T2489	2777-2780	CC	denotes	and
T2490	2781-2786	PRP$	denotes	their
T2491	2787-2798	NNS	denotes	spermatozoa
T2492	2799-2803	VBP	denotes	lack
T2493	2804-2807	NN	denotes	egg
T2495	2807-2808	HYPH	denotes	-
T2496	2808-2815	VBG	denotes	binding
T2494	2816-2825	NNS	denotes	abilities
T2497	2826-2827	-LRB-	denotes	[
T2498	2827-2829	CD	denotes	14
T2499	2829-2830	SYM	denotes	-
T2500	2830-2832	CD	denotes	16
T2501	2832-2833	-RRB-	denotes	]
T2502	2833-2834	.	denotes	.
T2503	2834-2885	sentence	denotes	The precise mechanism is under investigation [17].
T2504	2835-2838	DT	denotes	The
T2506	2839-2846	JJ	denotes	precise
T2505	2847-2856	NN	denotes	mechanism
T2507	2857-2859	VBZ	denotes	is
T2508	2860-2865	IN	denotes	under
T2509	2866-2879	NN	denotes	investigation
T2510	2880-2881	-LRB-	denotes	[
T2511	2881-2883	CD	denotes	17
T2512	2883-2884	-RRB-	denotes	]
T2513	2884-2885	.	denotes	.
T2514	2885-3031	sentence	denotes	We have reported the findings of ADAM11, ADAM22 and ADAM23 genes and their restricted expression in the human and murine nervous systems [18,19].
T2515	2886-2888	PRP	denotes	We
T2517	2889-2893	VBP	denotes	have
T2516	2894-2902	VBN	denotes	reported
T2518	2903-2906	DT	denotes	the
T2519	2907-2915	NNS	denotes	findings
T2520	2916-2918	IN	denotes	of
T2521	2919-2925	NN	denotes	ADAM11
T2523	2925-2927	,	denotes	,
T2524	2927-2933	NN	denotes	ADAM22
T2525	2934-2937	CC	denotes	and
T2526	2938-2944	NN	denotes	ADAM23
T2522	2945-2950	NNS	denotes	genes
T2527	2951-2954	CC	denotes	and
T2528	2955-2960	PRP$	denotes	their
T2530	2961-2971	VBN	denotes	restricted
T2529	2972-2982	NN	denotes	expression
T2531	2983-2985	IN	denotes	in
T2532	2986-2989	DT	denotes	the
T2534	2990-2995	JJ	denotes	human
T2535	2996-2999	CC	denotes	and
T2536	3000-3006	JJ	denotes	murine
T2537	3007-3014	JJ	denotes	nervous
T2533	3015-3022	NNS	denotes	systems
T2538	3023-3024	-LRB-	denotes	[
T2540	3024-3026	CD	denotes	18
T2541	3026-3027	,	denotes	,
T2539	3027-3029	CD	denotes	19
T2542	3029-3030	-RRB-	denotes	]
T2543	3030-3031	.	denotes	.
T2544	3031-3151	sentence	denotes	These ADAMs lack a catalytic motif critical for the metalloproteinase activity, suggesting that they are not proteases.
T2545	3032-3037	DT	denotes	These
T2546	3038-3043	NNS	denotes	ADAMs
T2547	3044-3048	VBP	denotes	lack
T2548	3049-3050	DT	denotes	a
T2550	3051-3060	JJ	denotes	catalytic
T2549	3061-3066	NN	denotes	motif
T2551	3067-3075	JJ	denotes	critical
T2552	3076-3079	IN	denotes	for
T2553	3080-3083	DT	denotes	the
T2555	3084-3101	NN	denotes	metalloproteinase
T2554	3102-3110	NN	denotes	activity
T2556	3110-3112	,	denotes	,
T2557	3112-3122	VBG	denotes	suggesting
T2558	3123-3127	IN	denotes	that
T2560	3128-3132	PRP	denotes	they
T2559	3133-3136	VBP	denotes	are
T2561	3137-3140	RB	denotes	not
T2562	3141-3150	NNS	denotes	proteases
T2563	3150-3151	.	denotes	.
T2564	3151-3360	sentence	denotes	We assume that these ADAMs might contribute to cell migration, differentiation and survival or synaptic regulation by binding to integrins, cell-surface proteins or intracellular signalling molecules [20,21].
T2565	3152-3154	PRP	denotes	We
T2566	3155-3161	VBP	denotes	assume
T2567	3162-3166	IN	denotes	that
T2569	3167-3172	DT	denotes	these
T2570	3173-3178	NNS	denotes	ADAMs
T2571	3179-3184	MD	denotes	might
T2568	3185-3195	VB	denotes	contribute
T2572	3196-3198	IN	denotes	to
T2573	3199-3203	NN	denotes	cell
T2574	3204-3213	NN	denotes	migration
T2575	3213-3215	,	denotes	,
T2576	3215-3230	NN	denotes	differentiation
T2577	3231-3234	CC	denotes	and
T2578	3235-3243	NN	denotes	survival
T2579	3244-3246	CC	denotes	or
T2580	3247-3255	JJ	denotes	synaptic
T2581	3256-3266	NN	denotes	regulation
T2582	3267-3269	IN	denotes	by
T2583	3270-3277	VBG	denotes	binding
T2584	3278-3280	IN	denotes	to
T2585	3281-3290	NNS	denotes	integrins
T2586	3290-3292	,	denotes	,
T2587	3292-3296	NN	denotes	cell
T2589	3296-3297	HYPH	denotes	-
T2588	3297-3304	NN	denotes	surface
T2590	3305-3313	NN	denotes	proteins
T2591	3314-3316	CC	denotes	or
T2592	3317-3330	JJ	denotes	intracellular
T2594	3331-3341	NN	denotes	signalling
T2593	3342-3351	NNS	denotes	molecules
T2595	3352-3353	-LRB-	denotes	[
T2597	3353-3355	CD	denotes	20
T2598	3355-3356	,	denotes	,
T2596	3356-3358	CD	denotes	21
T2599	3358-3359	-RRB-	denotes	]
T2600	3359-3360	.	denotes	.
T2601	3360-3527	sentence	denotes	We have reported severe ataxia, seizures, and death before weaning, accompanied with hypomyelination of the peripheral nervous system in Adam22-null mutant mice [22].
T2602	3361-3363	PRP	denotes	We
T2604	3364-3368	VBP	denotes	have
T2603	3369-3377	VBN	denotes	reported
T2605	3378-3384	JJ	denotes	severe
T2606	3385-3391	NN	denotes	ataxia
T2607	3391-3393	,	denotes	,
T2608	3393-3401	NNS	denotes	seizures
T2609	3401-3403	,	denotes	,
T2610	3403-3406	CC	denotes	and
T2611	3407-3412	NN	denotes	death
T2612	3413-3419	IN	denotes	before
T2613	3420-3427	NN	denotes	weaning
T2614	3427-3429	,	denotes	,
T2615	3429-3440	VBN	denotes	accompanied
T2616	3441-3445	IN	denotes	with
T2617	3446-3461	NN	denotes	hypomyelination
T2618	3462-3464	IN	denotes	of
T2619	3465-3468	DT	denotes	the
T2621	3469-3479	JJ	denotes	peripheral
T2622	3480-3487	JJ	denotes	nervous
T2620	3488-3494	NN	denotes	system
T2623	3495-3497	IN	denotes	in
T2624	3498-3504	NN	denotes	Adam22
T2626	3504-3505	HYPH	denotes	-
T2625	3505-3509	JJ	denotes	null
T2628	3510-3516	NN	denotes	mutant
T2627	3517-3521	NNS	denotes	mice
T2629	3522-3523	-LRB-	denotes	[
T2630	3523-3525	CD	denotes	22
T2631	3525-3526	-RRB-	denotes	]
T2632	3526-3527	.	denotes	.
T2633	3527-3663	sentence	denotes	It has been reported that the disruption of Adam23 gene in the mouse results in premature death associated with ataxia and tremor [23].
T2634	3528-3530	PRP	denotes	It
T2636	3531-3534	VBZ	denotes	has
T2637	3535-3539	VBN	denotes	been
T2635	3540-3548	VBN	denotes	reported
T2638	3549-3553	IN	denotes	that
T2640	3554-3557	DT	denotes	the
T2641	3558-3568	NN	denotes	disruption
T2642	3569-3571	IN	denotes	of
T2643	3572-3578	NN	denotes	Adam23
T2644	3579-3583	NN	denotes	gene
T2645	3584-3586	IN	denotes	in
T2646	3587-3590	DT	denotes	the
T2647	3591-3596	NN	denotes	mouse
T2639	3597-3604	VBZ	denotes	results
T2648	3605-3607	IN	denotes	in
T2649	3608-3617	JJ	denotes	premature
T2650	3618-3623	NN	denotes	death
T2651	3624-3634	VBN	denotes	associated
T2652	3635-3639	IN	denotes	with
T2653	3640-3646	NN	denotes	ataxia
T2654	3647-3650	CC	denotes	and
T2655	3651-3657	NN	denotes	tremor
T2656	3658-3659	-LRB-	denotes	[
T2657	3659-3661	CD	denotes	23
T2658	3661-3662	-RRB-	denotes	]
T2659	3662-3663	.	denotes	.
T2660	3663-3799	sentence	denotes	Is spite of such extreme phenotypes, no histological defects in the brain has been observed in either Adam22-null nor Adam23-null mice.
T2661	3664-3666	IN	denotes	Is
T2663	3667-3672	NN	denotes	spite
T2664	3673-3675	IN	denotes	of
T2665	3676-3680	JJ	denotes	such
T2667	3681-3688	JJ	denotes	extreme
T2666	3689-3699	NNS	denotes	phenotypes
T2668	3699-3701	,	denotes	,
T2669	3701-3703	DT	denotes	no
T2671	3704-3716	JJ	denotes	histological
T2670	3717-3724	NNS	denotes	defects
T2672	3725-3727	IN	denotes	in
T2673	3728-3731	DT	denotes	the
T2674	3732-3737	NN	denotes	brain
T2675	3738-3741	VBZ	denotes	has
T2676	3742-3746	VBN	denotes	been
T2662	3747-3755	VBN	denotes	observed
T2677	3756-3758	IN	denotes	in
T2678	3759-3765	CC	denotes	either
T2680	3766-3772	NN	denotes	Adam22
T2682	3772-3773	HYPH	denotes	-
T2681	3773-3777	JJ	denotes	null
T2683	3778-3781	CC	denotes	nor
T2684	3782-3788	NN	denotes	Adam23
T2686	3788-3789	HYPH	denotes	-
T2685	3789-3793	JJ	denotes	null
T2679	3794-3798	NNS	denotes	mice
T2687	3798-3799	.	denotes	.
T2688	3799-3927	sentence	denotes	ADAM11 is the closest paralog of ADAM22 and ADAM23, and its orthologs have been found in vertebrates, but not in invertebrates.
T2689	3800-3806	NN	denotes	ADAM11
T2690	3807-3809	VBZ	denotes	is
T2691	3810-3813	DT	denotes	the
T2693	3814-3821	JJS	denotes	closest
T2692	3822-3829	NN	denotes	paralog
T2694	3830-3832	IN	denotes	of
T2695	3833-3839	NN	denotes	ADAM22
T2696	3840-3843	CC	denotes	and
T2697	3844-3850	NN	denotes	ADAM23
T2698	3850-3852	,	denotes	,
T2699	3852-3855	CC	denotes	and
T2700	3856-3859	PRP$	denotes	its
T2701	3860-3869	NNS	denotes	orthologs
T2703	3870-3874	VBP	denotes	have
T2704	3875-3879	VBN	denotes	been
T2702	3880-3885	VBN	denotes	found
T2705	3886-3888	IN	denotes	in
T2706	3889-3900	NNS	denotes	vertebrates
T2707	3900-3902	,	denotes	,
T2708	3902-3905	CC	denotes	but
T2709	3906-3909	RB	denotes	not
T2710	3910-3912	IN	denotes	in
T2711	3913-3926	NNS	denotes	invertebrates
T2712	3926-3927	.	denotes	.
T2713	3927-4287	sentence	denotes	It has been reported that the Xenopus ADAM11 ortholog, xMDC11a, has an expression pattern associated with neural development, with a proposed role in cell migration [24]; and it has been reported in analyses using Northern blot and in situ hybridisation methods that the murine Adam11 gene is expressed in both the developing and adult nervous system [19,25].
T2714	3928-3930	PRP	denotes	It
T2716	3931-3934	VBZ	denotes	has
T2717	3935-3939	VBN	denotes	been
T2715	3940-3948	VBN	denotes	reported
T2718	3949-3953	IN	denotes	that
T2720	3954-3957	DT	denotes	the
T2722	3958-3965	NNP	denotes	Xenopus
T2723	3966-3972	NN	denotes	ADAM11
T2721	3973-3981	NN	denotes	ortholog
T2724	3981-3983	,	denotes	,
T2725	3983-3990	NN	denotes	xMDC11a
T2726	3990-3992	,	denotes	,
T2719	3992-3995	VBZ	denotes	has
T2727	3996-3998	DT	denotes	an
T2729	3999-4009	NN	denotes	expression
T2728	4010-4017	NN	denotes	pattern
T2730	4018-4028	VBN	denotes	associated
T2731	4029-4033	IN	denotes	with
T2732	4034-4040	JJ	denotes	neural
T2733	4041-4052	NN	denotes	development
T2734	4052-4054	,	denotes	,
T2735	4054-4058	IN	denotes	with
T2736	4059-4060	DT	denotes	a
T2738	4061-4069	VBN	denotes	proposed
T2737	4070-4074	NN	denotes	role
T2739	4075-4077	IN	denotes	in
T2740	4078-4082	NN	denotes	cell
T2741	4083-4092	NN	denotes	migration
T2742	4093-4094	-LRB-	denotes	[
T2743	4094-4096	CD	denotes	24
T2744	4096-4097	-RRB-	denotes	]
T2745	4097-4098	:	denotes	;
T2746	4099-4102	CC	denotes	and
T2747	4103-4105	PRP	denotes	it
T2749	4106-4109	VBZ	denotes	has
T2750	4110-4114	VBN	denotes	been
T2748	4115-4123	VBN	denotes	reported
T2751	4124-4126	IN	denotes	in
T2752	4127-4135	NNS	denotes	analyses
T2753	4136-4141	VBG	denotes	using
T2754	4142-4150	NNP	denotes	Northern
T2755	4151-4155	NN	denotes	blot
T2757	4156-4159	CC	denotes	and
T2758	4160-4162	FW	denotes	in
T2759	4163-4167	FW	denotes	situ
T2760	4168-4181	NN	denotes	hybridisation
T2756	4182-4189	NNS	denotes	methods
T2761	4190-4194	IN	denotes	that
T2763	4195-4198	DT	denotes	the
T2765	4199-4205	JJ	denotes	murine
T2766	4206-4212	NN	denotes	Adam11
T2764	4213-4217	NN	denotes	gene
T2767	4218-4220	VBZ	denotes	is
T2762	4221-4230	VBN	denotes	expressed
T2768	4231-4233	IN	denotes	in
T2769	4234-4238	CC	denotes	both
T2771	4239-4242	DT	denotes	the
T2772	4243-4253	VBG	denotes	developing
T2773	4254-4257	CC	denotes	and
T2774	4258-4263	JJ	denotes	adult
T2775	4264-4271	JJ	denotes	nervous
T2770	4272-4278	NN	denotes	system
T2776	4279-4280	-LRB-	denotes	[
T2778	4280-4282	CD	denotes	19
T2779	4282-4283	,	denotes	,
T2777	4283-4285	CD	denotes	25
T2780	4285-4286	-RRB-	denotes	]
T2781	4286-4287	.	denotes	.
T2782	4287-4435	sentence	denotes	These findings led us to hypothesise that ADAM11 is an integrin binder that plays an important role in the nervous system, as do ADAM22 and ADAM23.
T2783	4288-4293	DT	denotes	These
T2784	4294-4302	NNS	denotes	findings
T2785	4303-4306	VBD	denotes	led
T2786	4307-4309	PRP	denotes	us
T2787	4310-4312	TO	denotes	to
T2788	4313-4324	VB	denotes	hypothesise
T2789	4325-4329	IN	denotes	that
T2791	4330-4336	NN	denotes	ADAM11
T2790	4337-4339	VBZ	denotes	is
T2792	4340-4342	DT	denotes	an
T2794	4343-4351	NN	denotes	integrin
T2793	4352-4358	NN	denotes	binder
T2795	4359-4363	WDT	denotes	that
T2796	4364-4369	VBZ	denotes	plays
T2797	4370-4372	DT	denotes	an
T2799	4373-4382	JJ	denotes	important
T2798	4383-4387	NN	denotes	role
T2800	4388-4390	IN	denotes	in
T2801	4391-4394	DT	denotes	the
T2803	4395-4402	JJ	denotes	nervous
T2802	4403-4409	NN	denotes	system
T2804	4409-4411	,	denotes	,
T2805	4411-4413	IN	denotes	as
T2806	4414-4416	VBP	denotes	do
T2807	4417-4423	NN	denotes	ADAM22
T2808	4424-4427	CC	denotes	and
T2809	4428-4434	NN	denotes	ADAM23
T2810	4434-4435	.	denotes	.
T2811	4435-4540	sentence	denotes	To determine the physiological functions of ADAM11, we generated and analysed Adam11 gene-targeted mice.
T2812	4436-4438	TO	denotes	To
T2813	4439-4448	VB	denotes	determine
T2815	4449-4452	DT	denotes	the
T2817	4453-4466	JJ	denotes	physiological
T2816	4467-4476	NNS	denotes	functions
T2818	4477-4479	IN	denotes	of
T2819	4480-4486	NN	denotes	ADAM11
T2820	4486-4488	,	denotes	,
T2821	4488-4490	PRP	denotes	we
T2814	4491-4500	VBD	denotes	generated
T2822	4501-4504	CC	denotes	and
T2823	4505-4513	VBD	denotes	analysed
T2824	4514-4520	NN	denotes	Adam11
T2826	4521-4525	NN	denotes	gene
T2828	4525-4526	HYPH	denotes	-
T2827	4526-4534	VBN	denotes	targeted
T2825	4535-4539	NNS	denotes	mice
T2829	4539-4540	.	denotes	.
T3214	4551-4561	NN	denotes	Generation
T3215	4562-4564	IN	denotes	of
T3216	4565-4571	NN	denotes	ADAM11
T3218	4571-4572	HYPH	denotes	-
T3217	4572-4581	JJ	denotes	deficient
T3219	4582-4586	NNS	denotes	mice
T3220	4586-4695	sentence	denotes	Mice carrying a targeted mutation in their Adam11 gene were generated by homologous recombination (Fig. 1A).
T3221	4587-4591	NNS	denotes	Mice
T3223	4592-4600	VBG	denotes	carrying
T3224	4601-4602	DT	denotes	a
T3226	4603-4611	VBN	denotes	targeted
T3225	4612-4620	NN	denotes	mutation
T3227	4621-4623	IN	denotes	in
T3228	4624-4629	PRP$	denotes	their
T3230	4630-4636	NN	denotes	Adam11
T3229	4637-4641	NN	denotes	gene
T3231	4642-4646	VBD	denotes	were
T3222	4647-4656	VBN	denotes	generated
T3232	4657-4659	IN	denotes	by
T3233	4660-4670	JJ	denotes	homologous
T3234	4671-4684	NN	denotes	recombination
T3235	4685-4686	-LRB-	denotes	(
T3237	4686-4690	NN	denotes	Fig.
T3236	4691-4693	NN	denotes	1A
T3238	4693-4694	-RRB-	denotes	)
T3239	4694-4695	.	denotes	.
T3240	4695-4772	sentence	denotes	Correct targeting events were confirmed by Southern blot analysis (Fig. 1B).
T3241	4696-4703	JJ	denotes	Correct
T3243	4704-4713	NN	denotes	targeting
T3242	4714-4720	NNS	denotes	events
T3245	4721-4725	VBD	denotes	were
T3244	4726-4735	VBN	denotes	confirmed
T3246	4736-4738	IN	denotes	by
T3247	4739-4747	NNP	denotes	Southern
T3248	4748-4752	NN	denotes	blot
T3249	4753-4761	NN	denotes	analysis
T3250	4762-4763	-LRB-	denotes	(
T3252	4763-4767	NN	denotes	Fig.
T3251	4768-4770	NN	denotes	1B
T3253	4770-4771	-RRB-	denotes	)
T3254	4771-4772	.	denotes	.
T3255	4772-4975	sentence	denotes	As a result of this procedure, since a termination codon was introduced in exon 5 in the pro-protein domain, only the truncated form of the ADAM11 protein would be synthesised from this targeted allele.
T3256	4773-4775	IN	denotes	As
T3258	4776-4777	DT	denotes	a
T3259	4778-4784	NN	denotes	result
T3260	4785-4787	IN	denotes	of
T3261	4788-4792	DT	denotes	this
T3262	4793-4802	NN	denotes	procedure
T3263	4802-4804	,	denotes	,
T3264	4804-4809	IN	denotes	since
T3266	4810-4811	DT	denotes	a
T3268	4812-4823	NN	denotes	termination
T3267	4824-4829	NN	denotes	codon
T3269	4830-4833	VBD	denotes	was
T3265	4834-4844	VBN	denotes	introduced
T3270	4845-4847	IN	denotes	in
T3271	4848-4852	NN	denotes	exon
T3272	4853-4854	CD	denotes	5
T3273	4855-4857	IN	denotes	in
T3274	4858-4861	DT	denotes	the
T3276	4862-4873	JJ	denotes	pro-protein
T3275	4874-4880	NN	denotes	domain
T3277	4880-4882	,	denotes	,
T3278	4882-4886	RB	denotes	only
T3280	4887-4890	DT	denotes	the
T3281	4891-4900	VBN	denotes	truncated
T3279	4901-4905	NN	denotes	form
T3282	4906-4908	IN	denotes	of
T3283	4909-4912	DT	denotes	the
T3285	4913-4919	NN	denotes	ADAM11
T3284	4920-4927	NN	denotes	protein
T3286	4928-4933	MD	denotes	would
T3287	4934-4936	VB	denotes	be
T3257	4937-4948	VBN	denotes	synthesised
T3288	4949-4953	IN	denotes	from
T3289	4954-4958	DT	denotes	this
T3291	4959-4967	VBN	denotes	targeted
T3290	4968-4974	NN	denotes	allele
T3292	4974-4975	.	denotes	.
T3293	4975-5209	sentence	denotes	Because pro-protein domains are always removed in mature functional ADAM-proteins by furin-like proteases and are thus thought to be non-functional, we concluded that this truncated form of ADAM11 protein would have no function [26].
T3294	4976-4983	IN	denotes	Because
T3296	4984-4995	JJ	denotes	pro-protein
T3297	4996-5003	NNS	denotes	domains
T3298	5004-5007	VBP	denotes	are
T3299	5008-5014	RB	denotes	always
T3295	5015-5022	VBN	denotes	removed
T3301	5023-5025	IN	denotes	in
T3302	5026-5032	JJ	denotes	mature
T3304	5033-5043	JJ	denotes	functional
T3305	5044-5048	NN	denotes	ADAM
T3306	5048-5049	HYPH	denotes	-
T3303	5049-5057	NN	denotes	proteins
T3307	5058-5060	IN	denotes	by
T3308	5061-5066	NN	denotes	furin
T3310	5066-5067	HYPH	denotes	-
T3309	5067-5071	JJ	denotes	like
T3311	5072-5081	NNS	denotes	proteases
T3312	5082-5085	CC	denotes	and
T3313	5086-5089	VBP	denotes	are
T3315	5090-5094	RB	denotes	thus
T3314	5095-5102	VBN	denotes	thought
T3316	5103-5105	TO	denotes	to
T3317	5106-5108	VB	denotes	be
T3318	5109-5123	JJ	denotes	non-functional
T3319	5123-5125	,	denotes	,
T3320	5125-5127	PRP	denotes	we
T3300	5128-5137	VBD	denotes	concluded
T3321	5138-5142	IN	denotes	that
T3323	5143-5147	DT	denotes	this
T3325	5148-5157	VBN	denotes	truncated
T3324	5158-5162	NN	denotes	form
T3326	5163-5165	IN	denotes	of
T3327	5166-5172	NN	denotes	ADAM11
T3328	5173-5180	NN	denotes	protein
T3329	5181-5186	MD	denotes	would
T3322	5187-5191	VB	denotes	have
T3330	5192-5194	DT	denotes	no
T3331	5195-5203	NN	denotes	function
T3332	5204-5205	-LRB-	denotes	[
T3333	5205-5207	CD	denotes	26
T3334	5207-5208	-RRB-	denotes	]
T3335	5208-5209	.	denotes	.
T3336	5209-5375	sentence	denotes	Absence of mature ADAM11 protein in homozygous mutants was confirmed by Western blot analysis using a specific antibody that recognises the ADAM11 protein (Fig. 1C).
T3337	5210-5217	NN	denotes	Absence
T3339	5218-5220	IN	denotes	of
T3340	5221-5227	JJ	denotes	mature
T3342	5228-5234	NN	denotes	ADAM11
T3341	5235-5242	NN	denotes	protein
T3343	5243-5245	IN	denotes	in
T3344	5246-5256	JJ	denotes	homozygous
T3345	5257-5264	NNS	denotes	mutants
T3346	5265-5268	VBD	denotes	was
T3338	5269-5278	VBN	denotes	confirmed
T3347	5279-5281	IN	denotes	by
T3348	5282-5289	NNP	denotes	Western
T3349	5290-5294	NN	denotes	blot
T3350	5295-5303	NN	denotes	analysis
T3351	5304-5309	VBG	denotes	using
T3352	5310-5311	DT	denotes	a
T3354	5312-5320	JJ	denotes	specific
T3353	5321-5329	NN	denotes	antibody
T3355	5330-5334	WDT	denotes	that
T3356	5335-5345	VBZ	denotes	recognises
T3357	5346-5349	DT	denotes	the
T3359	5350-5356	NN	denotes	ADAM11
T3358	5357-5364	NN	denotes	protein
T3360	5365-5366	-LRB-	denotes	(
T3362	5366-5370	NN	denotes	Fig.
T3361	5371-5373	NN	denotes	1C
T3363	5373-5374	-RRB-	denotes	)
T3364	5374-5375	.	denotes	.
T3365	5375-5504	sentence	denotes	Analysis by Western blot showed that heterozygous mutants produced approximately half of the wild-type levels of ADAM11 protein.
T3366	5376-5384	NN	denotes	Analysis
T3368	5385-5387	IN	denotes	by
T3369	5388-5395	NNP	denotes	Western
T3370	5396-5400	NN	denotes	blot
T3367	5401-5407	VBD	denotes	showed
T3371	5408-5412	IN	denotes	that
T3373	5413-5425	JJ	denotes	heterozygous
T3374	5426-5433	NNS	denotes	mutants
T3372	5434-5442	VBD	denotes	produced
T3375	5443-5456	RB	denotes	approximately
T3376	5457-5461	NN	denotes	half
T3377	5462-5464	IN	denotes	of
T3378	5465-5468	DT	denotes	the
T3380	5469-5473	JJ	denotes	wild
T3382	5473-5474	HYPH	denotes	-
T3381	5474-5478	NN	denotes	type
T3379	5479-5485	NNS	denotes	levels
T3383	5486-5488	IN	denotes	of
T3384	5489-5495	NN	denotes	ADAM11
T3385	5496-5503	NN	denotes	protein
T3386	5503-5504	.	denotes	.
T3987	5506-5512	NN	denotes	ADAM11
T3989	5512-5513	HYPH	denotes	-
T3988	5513-5522	JJ	denotes	deficient
T3990	5523-5527	NNS	denotes	mice
T3991	5528-5531	VBP	denotes	are
T3992	5532-5538	JJ	denotes	viable
T3993	5539-5542	CC	denotes	and
T3994	5543-5549	VB	denotes	appear
T3995	5550-5556	JJ	denotes	normal
T3996	5556-5756	sentence	denotes	Mating of mice heterozygous for the ADAM11 mutation yielded a near-Mendelian distribution of genotypes in the offspring and the ratio of females and males was the same in all groups (data not shown).
T3997	5557-5563	VBG	denotes	Mating
T3999	5564-5566	IN	denotes	of
T4000	5567-5571	NNS	denotes	mice
T4001	5572-5584	JJ	denotes	heterozygous
T4002	5585-5588	IN	denotes	for
T4003	5589-5592	DT	denotes	the
T4005	5593-5599	NN	denotes	ADAM11
T4004	5600-5608	NN	denotes	mutation
T3998	5609-5616	VBD	denotes	yielded
T4006	5617-5618	DT	denotes	a
T4008	5619-5623	JJ	denotes	near
T4010	5623-5624	HYPH	denotes	-
T4009	5624-5633	JJ	denotes	Mendelian
T4007	5634-5646	NN	denotes	distribution
T4011	5647-5649	IN	denotes	of
T4012	5650-5659	NNS	denotes	genotypes
T4013	5660-5662	IN	denotes	in
T4014	5663-5666	DT	denotes	the
T4015	5667-5676	NN	denotes	offspring
T4016	5677-5680	CC	denotes	and
T4017	5681-5684	DT	denotes	the
T4018	5685-5690	NN	denotes	ratio
T4020	5691-5693	IN	denotes	of
T4021	5694-5701	NNS	denotes	females
T4022	5702-5705	CC	denotes	and
T4023	5706-5711	NNS	denotes	males
T4019	5712-5715	VBD	denotes	was
T4024	5716-5719	DT	denotes	the
T4025	5720-5724	JJ	denotes	same
T4026	5725-5727	IN	denotes	in
T4027	5728-5731	DT	denotes	all
T4028	5732-5738	NNS	denotes	groups
T4029	5739-5740	-LRB-	denotes	(
T4031	5740-5744	NNS	denotes	data
T4032	5745-5748	RB	denotes	not
T4030	5749-5754	VBN	denotes	shown
T4033	5754-5755	-RRB-	denotes	)
T4034	5755-5756	.	denotes	.
T4035	5756-5938	sentence	denotes	For the present experiments, ADAM11-deficient male mice (backcrossed generations into C57BL/6NCrj, n = 14) were used in all behavioural analyses and anatomical-histological studies.
T4036	5757-5760	IN	denotes	For
T4038	5761-5764	DT	denotes	the
T4040	5765-5772	JJ	denotes	present
T4039	5773-5784	NNS	denotes	experiments
T4041	5784-5786	,	denotes	,
T4042	5786-5792	NN	denotes	ADAM11
T4044	5792-5793	HYPH	denotes	-
T4043	5793-5802	JJ	denotes	deficient
T4046	5803-5807	JJ	denotes	male
T4045	5808-5812	NNS	denotes	mice
T4047	5813-5814	-LRB-	denotes	(
T4049	5814-5825	VBN	denotes	backcrossed
T4048	5826-5837	NNS	denotes	generations
T4050	5838-5842	IN	denotes	into
T4051	5843-5848	NN	denotes	C57BL
T4053	5848-5849	HYPH	denotes	/
T4052	5849-5854	NN	denotes	6NCrj
T4054	5854-5856	,	denotes	,
T4055	5856-5857	NN	denotes	n
T4057	5858-5859	SYM	denotes	=
T4056	5860-5862	CD	denotes	14
T4058	5862-5863	-RRB-	denotes	)
T4059	5864-5868	VBD	denotes	were
T4037	5869-5873	VBN	denotes	used
T4060	5874-5876	IN	denotes	in
T4061	5877-5880	DT	denotes	all
T4063	5881-5892	JJ	denotes	behavioural
T4062	5893-5901	NNS	denotes	analyses
T4064	5902-5905	CC	denotes	and
T4065	5906-5916	JJ	denotes	anatomical
T4067	5916-5917	HYPH	denotes	-
T4066	5917-5929	JJ	denotes	histological
T4068	5930-5937	NNS	denotes	studies
T4069	5937-5938	.	denotes	.
T4070	5938-6082	sentence	denotes	Homozygous ADAM11-deficient mice were viable and appeared normal, indicating that the Adam11 gene is not essential to development and survival.
T4071	5939-5949	JJ	denotes	Homozygous
T4073	5950-5956	NN	denotes	ADAM11
T4075	5956-5957	HYPH	denotes	-
T4074	5957-5966	JJ	denotes	deficient
T4072	5967-5971	NNS	denotes	mice
T4076	5972-5976	VBD	denotes	were
T4077	5977-5983	JJ	denotes	viable
T4078	5984-5987	CC	denotes	and
T4079	5988-5996	VBD	denotes	appeared
T4080	5997-6003	JJ	denotes	normal
T4081	6003-6005	,	denotes	,
T4082	6005-6015	VBG	denotes	indicating
T4083	6016-6020	IN	denotes	that
T4085	6021-6024	DT	denotes	the
T4087	6025-6031	NN	denotes	Adam11
T4086	6032-6036	NN	denotes	gene
T4084	6037-6039	VBZ	denotes	is
T4088	6040-6043	RB	denotes	not
T4089	6044-6053	JJ	denotes	essential
T4090	6054-6056	IN	denotes	to
T4091	6057-6068	NN	denotes	development
T4092	6069-6072	CC	denotes	and
T4093	6073-6081	NN	denotes	survival
T4094	6081-6082	.	denotes	.
T4095	6082-6216	sentence	denotes	The gain in body weight of (-/-) mice was comparable to that of (+/+) and (+/-) mice at least until 24 weeks of age (data not shown).
T4096	6083-6086	DT	denotes	The
T4097	6087-6091	NN	denotes	gain
T4099	6092-6094	IN	denotes	in
T4100	6095-6099	NN	denotes	body
T4101	6100-6106	NN	denotes	weight
T4102	6107-6109	IN	denotes	of
T4103	6110-6111	-LRB-	denotes	(
T4105	6111-6112	SYM	denotes	-
T4107	6112-6113	HYPH	denotes	/
T4106	6113-6114	SYM	denotes	-
T4108	6114-6115	-RRB-	denotes	)
T4104	6116-6120	NNS	denotes	mice
T4098	6121-6124	VBD	denotes	was
T4109	6125-6135	JJ	denotes	comparable
T4110	6136-6138	IN	denotes	to
T4111	6139-6143	DT	denotes	that
T4112	6144-6146	IN	denotes	of
T4113	6147-6148	-LRB-	denotes	(
T4115	6148-6149	SYM	denotes	+
T4117	6149-6150	HYPH	denotes	/
T4116	6150-6151	SYM	denotes	+
T4118	6151-6152	-RRB-	denotes	)
T4119	6153-6156	CC	denotes	and
T4120	6157-6158	-LRB-	denotes	(
T4122	6158-6159	SYM	denotes	+
T4123	6159-6160	HYPH	denotes	/
T4121	6160-6161	SYM	denotes	-
T4124	6161-6162	-RRB-	denotes	)
T4114	6163-6167	NNS	denotes	mice
T4125	6168-6170	RB	denotes	at
T4126	6171-6176	RBS	denotes	least
T4127	6177-6182	IN	denotes	until
T4128	6183-6185	CD	denotes	24
T4129	6186-6191	NNS	denotes	weeks
T4130	6192-6194	IN	denotes	of
T4131	6195-6198	NN	denotes	age
T4132	6199-6200	-LRB-	denotes	(
T4134	6200-6204	NNS	denotes	data
T4135	6205-6208	RB	denotes	not
T4133	6209-6214	VBN	denotes	shown
T4136	6214-6215	-RRB-	denotes	)
T4137	6215-6216	.	denotes	.
T4138	6216-6331	sentence	denotes	There was no significant difference in locomotor activity among (+/+), (+/-) and (-/-) genotypes (data not shown).
T4139	6217-6222	EX	denotes	There
T4140	6223-6226	VBD	denotes	was
T4141	6227-6229	DT	denotes	no
T4143	6230-6241	JJ	denotes	significant
T4142	6242-6252	NN	denotes	difference
T4144	6253-6255	IN	denotes	in
T4145	6256-6265	NN	denotes	locomotor
T4146	6266-6274	NN	denotes	activity
T4147	6275-6280	IN	denotes	among
T4148	6281-6282	-LRB-	denotes	(
T4150	6282-6283	SYM	denotes	+
T4152	6283-6284	HYPH	denotes	/
T4151	6284-6285	SYM	denotes	+
T4153	6285-6286	-RRB-	denotes	)
T4154	6286-6288	,	denotes	,
T4155	6288-6289	-LRB-	denotes	(
T4157	6289-6290	SYM	denotes	+
T4158	6290-6291	HYPH	denotes	/
T4156	6291-6292	SYM	denotes	-
T4159	6292-6293	-RRB-	denotes	)
T4160	6294-6297	CC	denotes	and
T4161	6298-6299	-LRB-	denotes	(
T4163	6299-6300	SYM	denotes	-
T4164	6300-6301	HYPH	denotes	/
T4162	6301-6302	SYM	denotes	-
T4165	6302-6303	-RRB-	denotes	)
T4149	6304-6313	NNS	denotes	genotypes
T4166	6314-6315	-LRB-	denotes	(
T4168	6315-6319	NNS	denotes	data
T4169	6320-6323	RB	denotes	not
T4167	6324-6329	VBN	denotes	shown
T4170	6329-6330	-RRB-	denotes	)
T4171	6330-6331	.	denotes	.
T4172	6331-6477	sentence	denotes	No apparent anatomical-histological change was observed in the spinal cord, heart, lung, liver, kidney, spleen, testis or ovary (data not shown).
T4173	6332-6334	DT	denotes	No
T4175	6335-6343	JJ	denotes	apparent
T4176	6344-6354	JJ	denotes	anatomical
T4178	6354-6355	HYPH	denotes	-
T4177	6355-6367	JJ	denotes	histological
T4174	6368-6374	NN	denotes	change
T4180	6375-6378	VBD	denotes	was
T4179	6379-6387	VBN	denotes	observed
T4181	6388-6390	IN	denotes	in
T4182	6391-6394	DT	denotes	the
T4184	6395-6401	JJ	denotes	spinal
T4183	6402-6406	NN	denotes	cord
T4185	6406-6408	,	denotes	,
T4186	6408-6413	NN	denotes	heart
T4187	6413-6415	,	denotes	,
T4188	6415-6419	NN	denotes	lung
T4189	6419-6421	,	denotes	,
T4190	6421-6426	NN	denotes	liver
T4191	6426-6428	,	denotes	,
T4192	6428-6434	NN	denotes	kidney
T4193	6434-6436	,	denotes	,
T4194	6436-6442	NN	denotes	spleen
T4195	6442-6444	,	denotes	,
T4196	6444-6450	NN	denotes	testis
T4197	6451-6453	CC	denotes	or
T4198	6454-6459	NN	denotes	ovary
T4199	6460-6461	-LRB-	denotes	(
T4201	6461-6465	NNS	denotes	data
T4202	6466-6469	RB	denotes	not
T4200	6470-6475	VBN	denotes	shown
T4203	6475-6476	-RRB-	denotes	)
T4204	6476-6477	.	denotes	.
T4205	6477-6645	sentence	denotes	The brain of (-/-) mice, including the hippocampus (Fig. 1D) and cerebellum (Fig. 1E) appeared normal after HE staining when (+/+), (+/-) and (-/-) mice were compared.
T4206	6478-6481	DT	denotes	The
T4207	6482-6487	NN	denotes	brain
T4209	6488-6490	IN	denotes	of
T4210	6491-6492	-LRB-	denotes	(
T4212	6492-6493	SYM	denotes	-
T4214	6493-6494	HYPH	denotes	/
T4213	6494-6495	SYM	denotes	-
T4215	6495-6496	-RRB-	denotes	)
T4211	6497-6501	NNS	denotes	mice
T4216	6501-6503	,	denotes	,
T4217	6503-6512	VBG	denotes	including
T4218	6513-6516	DT	denotes	the
T4219	6517-6528	NN	denotes	hippocampus
T4220	6529-6530	-LRB-	denotes	(
T4222	6530-6534	NN	denotes	Fig.
T4221	6535-6537	NN	denotes	1D
T4223	6537-6538	-RRB-	denotes	)
T4224	6539-6542	CC	denotes	and
T4225	6543-6553	NN	denotes	cerebellum
T4226	6554-6555	-LRB-	denotes	(
T4228	6555-6559	NN	denotes	Fig.
T4227	6560-6562	NN	denotes	1E
T4229	6562-6563	-RRB-	denotes	)
T4208	6564-6572	VBD	denotes	appeared
T4230	6573-6579	JJ	denotes	normal
T4231	6580-6585	IN	denotes	after
T4232	6586-6588	NN	denotes	HE
T4233	6589-6597	NN	denotes	staining
T4234	6598-6602	WRB	denotes	when
T4236	6603-6604	-LRB-	denotes	(
T4238	6604-6605	SYM	denotes	+
T4240	6605-6606	HYPH	denotes	/
T4239	6606-6607	SYM	denotes	+
T4241	6607-6608	-RRB-	denotes	)
T4242	6608-6610	,	denotes	,
T4243	6610-6611	-LRB-	denotes	(
T4245	6611-6612	SYM	denotes	+
T4246	6612-6613	HYPH	denotes	/
T4244	6613-6614	SYM	denotes	-
T4247	6614-6615	-RRB-	denotes	)
T4248	6616-6619	CC	denotes	and
T4249	6620-6621	-LRB-	denotes	(
T4251	6621-6622	SYM	denotes	-
T4252	6622-6623	HYPH	denotes	/
T4250	6623-6624	SYM	denotes	-
T4253	6624-6625	-RRB-	denotes	)
T4237	6626-6630	NNS	denotes	mice
T4254	6631-6635	VBD	denotes	were
T4235	6636-6644	VBN	denotes	compared
T4255	6644-6645	.	denotes	.
T4256	6645-6790	sentence	denotes	Since Adam11 is predominantly expressed in the hippocampus and cerebellum, we applied hippocampus- or cerebellum-dependent behavioural analyses.
T4257	6646-6651	IN	denotes	Since
T4259	6652-6658	NN	denotes	Adam11
T4260	6659-6661	VBZ	denotes	is
T4261	6662-6675	RB	denotes	predominantly
T4258	6676-6685	VBN	denotes	expressed
T4263	6686-6688	IN	denotes	in
T4264	6689-6692	DT	denotes	the
T4265	6693-6704	NN	denotes	hippocampus
T4266	6705-6708	CC	denotes	and
T4267	6709-6719	NN	denotes	cerebellum
T4268	6719-6721	,	denotes	,
T4269	6721-6723	PRP	denotes	we
T4262	6724-6731	VBD	denotes	applied
T4270	6732-6743	NN	denotes	hippocampus
T4272	6743-6744	HYPH	denotes	-
T4273	6745-6747	CC	denotes	or
T4274	6748-6758	NN	denotes	cerebellum
T4275	6758-6759	HYPH	denotes	-
T4271	6759-6768	JJ	denotes	dependent
T4277	6769-6780	JJ	denotes	behavioural
T4276	6781-6789	NNS	denotes	analyses
T4278	6789-6790	.	denotes	.
T5242	6792-6799	JJ	denotes	Spatial
T5243	6800-6808	NN	denotes	learning
T5244	6809-6811	IN	denotes	in
T5245	6812-6818	NN	denotes	ADAM11
T5247	6818-6819	HYPH	denotes	-
T5246	6819-6828	JJ	denotes	deficient
T5248	6829-6833	NNS	denotes	mice
T5249	6833-6991	sentence	denotes	To study the functions of ADAM11 in the hippocampus, we examined the spatial learning ability of ADAM11-deficient mice using the Morris Water Maze task [27].
T5250	6834-6836	TO	denotes	To
T5251	6837-6842	VB	denotes	study
T5253	6843-6846	DT	denotes	the
T5254	6847-6856	NNS	denotes	functions
T5255	6857-6859	IN	denotes	of
T5256	6860-6866	NN	denotes	ADAM11
T5257	6867-6869	IN	denotes	in
T5258	6870-6873	DT	denotes	the
T5259	6874-6885	NN	denotes	hippocampus
T5260	6885-6887	,	denotes	,
T5261	6887-6889	PRP	denotes	we
T5252	6890-6898	VBD	denotes	examined
T5262	6899-6902	DT	denotes	the
T5264	6903-6910	JJ	denotes	spatial
T5265	6911-6919	NN	denotes	learning
T5263	6920-6927	NN	denotes	ability
T5266	6928-6930	IN	denotes	of
T5267	6931-6937	NN	denotes	ADAM11
T5269	6937-6938	HYPH	denotes	-
T5268	6938-6947	JJ	denotes	deficient
T5270	6948-6952	NNS	denotes	mice
T5271	6953-6958	VBG	denotes	using
T5272	6959-6962	DT	denotes	the
T5274	6963-6969	NNP	denotes	Morris
T5276	6970-6975	NNP	denotes	Water
T5275	6976-6980	NNP	denotes	Maze
T5273	6981-6985	NN	denotes	task
T5277	6986-6987	-LRB-	denotes	[
T5278	6987-6989	CD	denotes	27
T5279	6989-6990	-RRB-	denotes	]
T5280	6990-6991	.	denotes	.
T5281	6991-7117	sentence	denotes	First, mice were trained in a hidden platform task, in which mice searched for a submerged platform to escape from the water.
T5282	6992-6997	RB	denotes	First
T5284	6997-6999	,	denotes	,
T5285	6999-7003	NNS	denotes	mice
T5286	7004-7008	VBD	denotes	were
T5283	7009-7016	VBN	denotes	trained
T5287	7017-7019	IN	denotes	in
T5288	7020-7021	DT	denotes	a
T5290	7022-7028	JJ	denotes	hidden
T5291	7029-7037	NN	denotes	platform
T5289	7038-7042	NN	denotes	task
T5292	7042-7044	,	denotes	,
T5293	7044-7046	IN	denotes	in
T5295	7047-7052	WDT	denotes	which
T5296	7053-7057	NNS	denotes	mice
T5294	7058-7066	VBD	denotes	searched
T5297	7067-7070	IN	denotes	for
T5298	7071-7072	DT	denotes	a
T5300	7073-7082	VBN	denotes	submerged
T5299	7083-7091	NN	denotes	platform
T5301	7092-7094	TO	denotes	to
T5302	7095-7101	VB	denotes	escape
T5303	7102-7106	IN	denotes	from
T5304	7107-7110	DT	denotes	the
T5305	7111-7116	NN	denotes	water
T5306	7116-7117	.	denotes	.
T5307	7117-7249	sentence	denotes	Adam11 (-/-) mice were found to take a significantly longer time to locate the hidden platform than (+/+) and (+/-) mice (Fig. 2A).
T5308	7118-7124	NN	denotes	Adam11
T5310	7125-7126	-LRB-	denotes	(
T5311	7126-7127	SYM	denotes	-
T5312	7127-7128	HYPH	denotes	/
T5313	7128-7129	SYM	denotes	-
T5314	7129-7130	-RRB-	denotes	)
T5309	7131-7135	NNS	denotes	mice
T5316	7136-7140	VBD	denotes	were
T5315	7141-7146	VBN	denotes	found
T5317	7147-7149	TO	denotes	to
T5318	7150-7154	VB	denotes	take
T5319	7155-7156	DT	denotes	a
T5321	7157-7170	RB	denotes	significantly
T5322	7171-7177	JJR	denotes	longer
T5320	7178-7182	NN	denotes	time
T5323	7183-7185	TO	denotes	to
T5324	7186-7192	VB	denotes	locate
T5325	7193-7196	DT	denotes	the
T5327	7197-7203	JJ	denotes	hidden
T5326	7204-7212	NN	denotes	platform
T5328	7213-7217	IN	denotes	than
T5329	7218-7219	-LRB-	denotes	(
T5331	7219-7220	SYM	denotes	+
T5333	7220-7221	HYPH	denotes	/
T5332	7221-7222	SYM	denotes	+
T5334	7222-7223	-RRB-	denotes	)
T5335	7224-7227	CC	denotes	and
T5336	7228-7229	-LRB-	denotes	(
T5338	7229-7230	SYM	denotes	+
T5339	7230-7231	HYPH	denotes	/
T5337	7231-7232	SYM	denotes	-
T5340	7232-7233	-RRB-	denotes	)
T5330	7234-7238	NNS	denotes	mice
T5341	7239-7240	-LRB-	denotes	(
T5343	7240-7244	NN	denotes	Fig.
T5342	7245-7247	NN	denotes	2A
T5344	7247-7248	-RRB-	denotes	)
T5345	7248-7249	.	denotes	.
T5346	7249-7372	sentence	denotes	Nonetheless, the ability of (+/+), (+/-) and (-/-) mice to find the hidden platform improved over test sessions (Fig. 2A).
T5347	7250-7261	RB	denotes	Nonetheless
T5349	7261-7263	,	denotes	,
T5350	7263-7266	DT	denotes	the
T5351	7267-7274	NN	denotes	ability
T5352	7275-7277	IN	denotes	of
T5353	7278-7279	-LRB-	denotes	(
T5355	7279-7280	SYM	denotes	+
T5357	7280-7281	HYPH	denotes	/
T5356	7281-7282	SYM	denotes	+
T5358	7282-7283	-RRB-	denotes	)
T5359	7283-7285	,	denotes	,
T5360	7285-7286	-LRB-	denotes	(
T5362	7286-7287	SYM	denotes	+
T5363	7287-7288	HYPH	denotes	/
T5361	7288-7289	SYM	denotes	-
T5364	7289-7290	-RRB-	denotes	)
T5365	7291-7294	CC	denotes	and
T5366	7295-7296	-LRB-	denotes	(
T5368	7296-7297	SYM	denotes	-
T5369	7297-7298	HYPH	denotes	/
T5367	7298-7299	SYM	denotes	-
T5370	7299-7300	-RRB-	denotes	)
T5354	7301-7305	NNS	denotes	mice
T5371	7306-7308	TO	denotes	to
T5372	7309-7313	VB	denotes	find
T5373	7314-7317	DT	denotes	the
T5375	7318-7324	JJ	denotes	hidden
T5374	7325-7333	NN	denotes	platform
T5348	7334-7342	VBN	denotes	improved
T5376	7343-7347	IN	denotes	over
T5377	7348-7352	NN	denotes	test
T5378	7353-7361	NNS	denotes	sessions
T5379	7362-7363	-LRB-	denotes	(
T5381	7363-7367	NN	denotes	Fig.
T5380	7368-7370	NN	denotes	2A
T5382	7370-7371	-RRB-	denotes	)
T5383	7371-7372	.	denotes	.
T5384	7372-7596	sentence	denotes	Thus, (+/+), (+/-) and (-/-) mice were able to learn the location of the hidden platform during the course of the trials, although the capacity of (-/-) mice to find the platform was lower than that of (+/+) and (+/-) mice.
T5385	7373-7377	RB	denotes	Thus
T5387	7377-7379	,	denotes	,
T5388	7379-7380	-LRB-	denotes	(
T5390	7380-7381	SYM	denotes	+
T5392	7381-7382	HYPH	denotes	/
T5391	7382-7383	SYM	denotes	+
T5393	7383-7384	-RRB-	denotes	)
T5394	7384-7386	,	denotes	,
T5395	7386-7387	-LRB-	denotes	(
T5397	7387-7388	SYM	denotes	+
T5398	7388-7389	HYPH	denotes	/
T5396	7389-7390	SYM	denotes	-
T5399	7390-7391	-RRB-	denotes	)
T5400	7392-7395	CC	denotes	and
T5401	7396-7397	-LRB-	denotes	(
T5403	7397-7398	SYM	denotes	-
T5404	7398-7399	HYPH	denotes	/
T5402	7399-7400	SYM	denotes	-
T5405	7400-7401	-RRB-	denotes	)
T5389	7402-7406	NNS	denotes	mice
T5386	7407-7411	VBD	denotes	were
T5406	7412-7416	JJ	denotes	able
T5407	7417-7419	TO	denotes	to
T5408	7420-7425	VB	denotes	learn
T5409	7426-7429	DT	denotes	the
T5410	7430-7438	NN	denotes	location
T5411	7439-7441	IN	denotes	of
T5412	7442-7445	DT	denotes	the
T5414	7446-7452	JJ	denotes	hidden
T5413	7453-7461	NN	denotes	platform
T5415	7462-7468	IN	denotes	during
T5416	7469-7472	DT	denotes	the
T5417	7473-7479	NN	denotes	course
T5418	7480-7482	IN	denotes	of
T5419	7483-7486	DT	denotes	the
T5420	7487-7493	NNS	denotes	trials
T5421	7493-7495	,	denotes	,
T5422	7495-7503	IN	denotes	although
T5424	7504-7507	DT	denotes	the
T5425	7508-7516	NN	denotes	capacity
T5426	7517-7519	IN	denotes	of
T5427	7520-7521	-LRB-	denotes	(
T5428	7521-7522	SYM	denotes	-
T5430	7522-7523	HYPH	denotes	/
T5429	7523-7524	SYM	denotes	-
T5432	7524-7525	-RRB-	denotes	)
T5431	7526-7530	NNS	denotes	mice
T5433	7531-7533	TO	denotes	to
T5434	7534-7538	VB	denotes	find
T5435	7539-7542	DT	denotes	the
T5436	7543-7551	NN	denotes	platform
T5423	7552-7555	VBD	denotes	was
T5437	7556-7561	JJR	denotes	lower
T5438	7562-7566	IN	denotes	than
T5439	7567-7571	DT	denotes	that
T5440	7572-7574	IN	denotes	of
T5441	7575-7576	-LRB-	denotes	(
T5443	7576-7577	SYM	denotes	+
T5445	7577-7578	HYPH	denotes	/
T5444	7578-7579	SYM	denotes	+
T5446	7579-7580	-RRB-	denotes	)
T5447	7581-7584	CC	denotes	and
T5448	7585-7586	-LRB-	denotes	(
T5450	7586-7587	SYM	denotes	+
T5451	7587-7588	HYPH	denotes	/
T5449	7588-7589	SYM	denotes	-
T5452	7589-7590	-RRB-	denotes	)
T5442	7591-7595	NNS	denotes	mice
T5453	7595-7596	.	denotes	.
T5454	7596-7786	sentence	denotes	We further performed a probe test, in which the platform was removed from the pool after completion of the hidden platform task, and the trained mice were allowed to swim freely for 60 sec.
T5455	7597-7599	PRP	denotes	We
T5457	7600-7607	RB	denotes	further
T5456	7608-7617	VBD	denotes	performed
T5458	7618-7619	DT	denotes	a
T5460	7620-7625	NN	denotes	probe
T5459	7626-7630	NN	denotes	test
T5461	7630-7632	,	denotes	,
T5462	7632-7634	IN	denotes	in
T5464	7635-7640	WDT	denotes	which
T5465	7641-7644	DT	denotes	the
T5466	7645-7653	NN	denotes	platform
T5467	7654-7657	VBD	denotes	was
T5463	7658-7665	VBN	denotes	removed
T5468	7666-7670	IN	denotes	from
T5469	7671-7674	DT	denotes	the
T5470	7675-7679	NN	denotes	pool
T5471	7680-7685	IN	denotes	after
T5472	7686-7696	NN	denotes	completion
T5473	7697-7699	IN	denotes	of
T5474	7700-7703	DT	denotes	the
T5476	7704-7710	JJ	denotes	hidden
T5477	7711-7719	NN	denotes	platform
T5475	7720-7724	NN	denotes	task
T5478	7724-7726	,	denotes	,
T5479	7726-7729	CC	denotes	and
T5480	7730-7733	DT	denotes	the
T5482	7734-7741	VBN	denotes	trained
T5481	7742-7746	NNS	denotes	mice
T5484	7747-7751	VBD	denotes	were
T5483	7752-7759	VBN	denotes	allowed
T5485	7760-7762	TO	denotes	to
T5486	7763-7767	VB	denotes	swim
T5487	7768-7774	RB	denotes	freely
T5488	7775-7778	IN	denotes	for
T5489	7779-7781	CD	denotes	60
T5490	7782-7785	NN	denotes	sec
T5491	7785-7786	.	denotes	.
T5492	7786-7891	sentence	denotes	The time spent in the target quadrant of (-/-) is significantly lower than that of (+/+) mice (Fig. 2B).
T5493	7787-7790	DT	denotes	The
T5494	7791-7795	NN	denotes	time
T5496	7796-7801	VBN	denotes	spent
T5497	7802-7804	IN	denotes	in
T5498	7805-7808	DT	denotes	the
T5500	7809-7815	NN	denotes	target
T5499	7816-7824	NN	denotes	quadrant
T5501	7825-7827	IN	denotes	of
T5502	7828-7829	-LRB-	denotes	(
T5503	7829-7830	SYM	denotes	-
T5505	7830-7831	HYPH	denotes	/
T5504	7831-7832	SYM	denotes	-
T5506	7832-7833	-RRB-	denotes	)
T5495	7834-7836	VBZ	denotes	is
T5507	7837-7850	RB	denotes	significantly
T5508	7851-7856	JJR	denotes	lower
T5509	7857-7861	IN	denotes	than
T5510	7862-7866	DT	denotes	that
T5511	7867-7869	IN	denotes	of
T5512	7870-7871	-LRB-	denotes	(
T5514	7871-7872	SYM	denotes	+
T5516	7872-7873	HYPH	denotes	/
T5515	7873-7874	SYM	denotes	+
T5517	7874-7875	-RRB-	denotes	)
T5513	7876-7880	NNS	denotes	mice
T5518	7881-7882	-LRB-	denotes	(
T5520	7882-7886	NN	denotes	Fig.
T5519	7887-7889	NN	denotes	2B
T5521	7889-7890	-RRB-	denotes	)
T5522	7890-7891	.	denotes	.
T5523	7891-8046	sentence	denotes	Adam11 (+/-) mice appeared to spend a shorter time in the target quadrant, but there was no significant difference between (+/+) and (+/-) mice (Fig. 2B).
T5524	7892-7898	NN	denotes	Adam11
T5526	7899-7900	-LRB-	denotes	(
T5527	7900-7901	SYM	denotes	+
T5528	7901-7902	HYPH	denotes	/
T5529	7902-7903	SYM	denotes	-
T5530	7903-7904	-RRB-	denotes	)
T5525	7905-7909	NNS	denotes	mice
T5531	7910-7918	VBD	denotes	appeared
T5532	7919-7921	TO	denotes	to
T5533	7922-7927	VB	denotes	spend
T5534	7928-7929	DT	denotes	a
T5536	7930-7937	JJR	denotes	shorter
T5535	7938-7942	NN	denotes	time
T5537	7943-7945	IN	denotes	in
T5538	7946-7949	DT	denotes	the
T5540	7950-7956	NN	denotes	target
T5539	7957-7965	NN	denotes	quadrant
T5541	7965-7967	,	denotes	,
T5542	7967-7970	CC	denotes	but
T5543	7971-7976	EX	denotes	there
T5544	7977-7980	VBD	denotes	was
T5545	7981-7983	DT	denotes	no
T5547	7984-7995	JJ	denotes	significant
T5546	7996-8006	NN	denotes	difference
T5548	8007-8014	IN	denotes	between
T5549	8015-8016	-LRB-	denotes	(
T5550	8016-8017	SYM	denotes	+
T5552	8017-8018	HYPH	denotes	/
T5551	8018-8019	SYM	denotes	+
T5554	8019-8020	-RRB-	denotes	)
T5555	8021-8024	CC	denotes	and
T5556	8025-8026	-LRB-	denotes	(
T5558	8026-8027	SYM	denotes	+
T5559	8027-8028	HYPH	denotes	/
T5557	8028-8029	SYM	denotes	-
T5560	8029-8030	-RRB-	denotes	)
T5553	8031-8035	NNS	denotes	mice
T5561	8036-8037	-LRB-	denotes	(
T5563	8037-8041	NN	denotes	Fig.
T5562	8042-8044	NN	denotes	2B
T5564	8044-8045	-RRB-	denotes	)
T5565	8045-8046	.	denotes	.
T5566	8046-8114	sentence	denotes	These results indicate a spatial learning impairment in (-/-) mice.
T5567	8047-8052	DT	denotes	These
T5568	8053-8060	NNS	denotes	results
T5569	8061-8069	VBP	denotes	indicate
T5570	8070-8071	DT	denotes	a
T5572	8072-8079	JJ	denotes	spatial
T5573	8080-8088	NN	denotes	learning
T5571	8089-8099	NN	denotes	impairment
T5574	8100-8102	IN	denotes	in
T5575	8103-8104	-LRB-	denotes	(
T5577	8104-8105	SYM	denotes	-
T5579	8105-8106	HYPH	denotes	/
T5578	8106-8107	SYM	denotes	-
T5580	8107-8108	-RRB-	denotes	)
T5576	8109-8113	NNS	denotes	mice
T5581	8113-8114	.	denotes	.
T5582	8114-8223	sentence	denotes	The swimming distance of (+/+), (+/-) and (-/-) mice, however, was similar during the probe trial (Fig. 2C).
T5583	8115-8118	DT	denotes	The
T5585	8119-8127	NN	denotes	swimming
T5584	8128-8136	NN	denotes	distance
T5587	8137-8139	IN	denotes	of
T5588	8140-8141	-LRB-	denotes	(
T5590	8141-8142	SYM	denotes	+
T5592	8142-8143	HYPH	denotes	/
T5591	8143-8144	SYM	denotes	+
T5593	8144-8145	-RRB-	denotes	)
T5594	8145-8147	,	denotes	,
T5595	8147-8148	-LRB-	denotes	(
T5597	8148-8149	SYM	denotes	+
T5598	8149-8150	HYPH	denotes	/
T5596	8150-8151	SYM	denotes	-
T5599	8151-8152	-RRB-	denotes	)
T5600	8153-8156	CC	denotes	and
T5601	8157-8158	-LRB-	denotes	(
T5603	8158-8159	SYM	denotes	-
T5604	8159-8160	HYPH	denotes	/
T5602	8160-8161	SYM	denotes	-
T5605	8161-8162	-RRB-	denotes	)
T5589	8163-8167	NNS	denotes	mice
T5606	8167-8169	,	denotes	,
T5607	8169-8176	RB	denotes	however
T5608	8176-8178	,	denotes	,
T5586	8178-8181	VBD	denotes	was
T5609	8182-8189	JJ	denotes	similar
T5610	8190-8196	IN	denotes	during
T5611	8197-8200	DT	denotes	the
T5613	8201-8206	NN	denotes	probe
T5612	8207-8212	NN	denotes	trial
T5614	8213-8214	-LRB-	denotes	(
T5616	8214-8218	NN	denotes	Fig.
T5615	8219-8221	NN	denotes	2C
T5617	8221-8222	-RRB-	denotes	)
T5618	8222-8223	.	denotes	.
T5619	8223-8553	sentence	denotes	In the visible platform task, the performance of mice with (+/+), (+/-) and (-/-) genotypes improved during the course of the test sessions, as indicated by a progressive decrease in the latency for locating the platform (Fig. 2D), suggesting that (-/-) mice learn this visible platform task just as well as (+/+) and (+/-) mice.
T5620	8224-8226	IN	denotes	In
T5622	8227-8230	DT	denotes	the
T5624	8231-8238	JJ	denotes	visible
T5625	8239-8247	NN	denotes	platform
T5623	8248-8252	NN	denotes	task
T5626	8252-8254	,	denotes	,
T5627	8254-8257	DT	denotes	the
T5628	8258-8269	NN	denotes	performance
T5629	8270-8272	IN	denotes	of
T5630	8273-8277	NNS	denotes	mice
T5631	8278-8282	IN	denotes	with
T5632	8283-8284	-LRB-	denotes	(
T5634	8284-8285	SYM	denotes	+
T5636	8285-8286	HYPH	denotes	/
T5635	8286-8287	SYM	denotes	+
T5637	8287-8288	-RRB-	denotes	)
T5638	8288-8290	,	denotes	,
T5639	8290-8291	-LRB-	denotes	(
T5641	8291-8292	SYM	denotes	+
T5642	8292-8293	HYPH	denotes	/
T5640	8293-8294	SYM	denotes	-
T5643	8294-8295	-RRB-	denotes	)
T5644	8296-8299	CC	denotes	and
T5645	8300-8301	-LRB-	denotes	(
T5647	8301-8302	SYM	denotes	-
T5648	8302-8303	HYPH	denotes	/
T5646	8303-8304	SYM	denotes	-
T5649	8304-8305	-RRB-	denotes	)
T5633	8306-8315	NNS	denotes	genotypes
T5621	8316-8324	VBD	denotes	improved
T5650	8325-8331	IN	denotes	during
T5651	8332-8335	DT	denotes	the
T5652	8336-8342	NN	denotes	course
T5653	8343-8345	IN	denotes	of
T5654	8346-8349	DT	denotes	the
T5656	8350-8354	NN	denotes	test
T5655	8355-8363	NNS	denotes	sessions
T5657	8363-8365	,	denotes	,
T5658	8365-8367	IN	denotes	as
T5659	8368-8377	VBN	denotes	indicated
T5660	8378-8380	IN	denotes	by
T5661	8381-8382	DT	denotes	a
T5663	8383-8394	JJ	denotes	progressive
T5662	8395-8403	NN	denotes	decrease
T5664	8404-8406	IN	denotes	in
T5665	8407-8410	DT	denotes	the
T5666	8411-8418	NN	denotes	latency
T5667	8419-8422	IN	denotes	for
T5668	8423-8431	VBG	denotes	locating
T5669	8432-8435	DT	denotes	the
T5670	8436-8444	NN	denotes	platform
T5671	8445-8446	-LRB-	denotes	(
T5673	8446-8450	NN	denotes	Fig.
T5672	8451-8453	NN	denotes	2D
T5674	8453-8454	-RRB-	denotes	)
T5675	8454-8456	,	denotes	,
T5676	8456-8466	VBG	denotes	suggesting
T5677	8467-8471	IN	denotes	that
T5679	8472-8473	-LRB-	denotes	(
T5681	8473-8474	SYM	denotes	-
T5683	8474-8475	HYPH	denotes	/
T5682	8475-8476	SYM	denotes	-
T5684	8476-8477	-RRB-	denotes	)
T5680	8478-8482	NNS	denotes	mice
T5678	8483-8488	VBP	denotes	learn
T5685	8489-8493	DT	denotes	this
T5687	8494-8501	JJ	denotes	visible
T5688	8502-8510	NN	denotes	platform
T5686	8511-8515	NN	denotes	task
T5689	8516-8520	RB	denotes	just
T5691	8521-8523	RB	denotes	as
T5690	8524-8528	RB	denotes	well
T5692	8529-8531	IN	denotes	as
T5693	8532-8533	-LRB-	denotes	(
T5695	8533-8534	SYM	denotes	+
T5697	8534-8535	HYPH	denotes	/
T5696	8535-8536	SYM	denotes	+
T5698	8536-8537	-RRB-	denotes	)
T5699	8538-8541	CC	denotes	and
T5700	8542-8543	-LRB-	denotes	(
T5702	8543-8544	SYM	denotes	+
T5703	8544-8545	HYPH	denotes	/
T5701	8545-8546	SYM	denotes	-
T5704	8546-8547	-RRB-	denotes	)
T5694	8548-8552	NNS	denotes	mice
T5705	8552-8553	.	denotes	.
T5706	8553-8687	sentence	denotes	These results also indicated that (-/-) mice have normal visible and motor function and the motivation needed in the water maze task.
T5707	8554-8559	DT	denotes	These
T5708	8560-8567	NNS	denotes	results
T5710	8568-8572	RB	denotes	also
T5709	8573-8582	VBD	denotes	indicated
T5711	8583-8587	IN	denotes	that
T5713	8588-8589	-LRB-	denotes	(
T5715	8589-8590	SYM	denotes	-
T5717	8590-8591	HYPH	denotes	/
T5716	8591-8592	SYM	denotes	-
T5718	8592-8593	-RRB-	denotes	)
T5714	8594-8598	NNS	denotes	mice
T5712	8599-8603	VBP	denotes	have
T5719	8604-8610	JJ	denotes	normal
T5721	8611-8618	JJ	denotes	visible
T5722	8619-8622	CC	denotes	and
T5723	8623-8628	JJ	denotes	motor
T5720	8629-8637	NN	denotes	function
T5724	8638-8641	CC	denotes	and
T5725	8642-8645	DT	denotes	the
T5726	8646-8656	NN	denotes	motivation
T5727	8657-8663	VBN	denotes	needed
T5728	8664-8666	IN	denotes	in
T5729	8667-8670	DT	denotes	the
T5731	8671-8676	NN	denotes	water
T5732	8677-8681	NN	denotes	maze
T5730	8682-8686	NN	denotes	task
T5733	8686-8687	.	denotes	.
T6623	8689-8694	NN	denotes	Motor
T6624	8695-8703	NN	denotes	function
T6625	8704-8706	IN	denotes	of
T6626	8707-8713	NN	denotes	ADAM11
T6628	8713-8714	HYPH	denotes	-
T6627	8714-8723	JJ	denotes	deficient
T6629	8724-8728	NNS	denotes	mice
T6630	8728-8868	sentence	denotes	To study the functions of ADAM11 in the cerebellum, we examined the motor function of ADAM11-deficient mice using a rotating rod task [28].
T6631	8729-8731	TO	denotes	To
T6632	8732-8737	VB	denotes	study
T6634	8738-8741	DT	denotes	the
T6635	8742-8751	NNS	denotes	functions
T6636	8752-8754	IN	denotes	of
T6637	8755-8761	NN	denotes	ADAM11
T6638	8762-8764	IN	denotes	in
T6639	8765-8768	DT	denotes	the
T6640	8769-8779	NN	denotes	cerebellum
T6641	8779-8781	,	denotes	,
T6642	8781-8783	PRP	denotes	we
T6633	8784-8792	VBD	denotes	examined
T6643	8793-8796	DT	denotes	the
T6645	8797-8802	JJ	denotes	motor
T6644	8803-8811	NN	denotes	function
T6646	8812-8814	IN	denotes	of
T6647	8815-8821	NN	denotes	ADAM11
T6649	8821-8822	HYPH	denotes	-
T6648	8822-8831	JJ	denotes	deficient
T6650	8832-8836	NNS	denotes	mice
T6651	8837-8842	VBG	denotes	using
T6652	8843-8844	DT	denotes	a
T6654	8845-8853	VBG	denotes	rotating
T6655	8854-8857	NN	denotes	rod
T6653	8858-8862	NN	denotes	task
T6656	8863-8864	-LRB-	denotes	[
T6657	8864-8866	CD	denotes	28
T6658	8866-8867	-RRB-	denotes	]
T6659	8867-8868	.	denotes	.
T6660	8868-9105	sentence	denotes	In the rotating rod test, the retention time of (+/-) and (-/-) mice on the rod was not significantly different from that of (+/+) mice at 0 rpm (stationary) [+/-: F (1, 80) = 1.67, p = 0.21; -/-: F (1, 88) = 0.002, p = 0.96] (Fig. 3A).
T6661	8869-8871	IN	denotes	In
T6663	8872-8875	DT	denotes	the
T6665	8876-8884	VBG	denotes	rotating
T6666	8885-8888	NN	denotes	rod
T6664	8889-8893	NN	denotes	test
T6667	8893-8895	,	denotes	,
T6668	8895-8898	DT	denotes	the
T6670	8899-8908	NN	denotes	retention
T6669	8909-8913	NN	denotes	time
T6671	8914-8916	IN	denotes	of
T6672	8917-8918	-LRB-	denotes	(
T6674	8918-8919	SYM	denotes	+
T6676	8919-8920	HYPH	denotes	/
T6675	8920-8921	SYM	denotes	-
T6677	8921-8922	-RRB-	denotes	)
T6678	8923-8926	CC	denotes	and
T6679	8927-8928	-LRB-	denotes	(
T6681	8928-8929	SYM	denotes	-
T6682	8929-8930	HYPH	denotes	/
T6680	8930-8931	SYM	denotes	-
T6683	8931-8932	-RRB-	denotes	)
T6673	8933-8937	NNS	denotes	mice
T6684	8938-8940	IN	denotes	on
T6685	8941-8944	DT	denotes	the
T6686	8945-8948	NN	denotes	rod
T6662	8949-8952	VBD	denotes	was
T6687	8953-8956	RB	denotes	not
T6688	8957-8970	RB	denotes	significantly
T6689	8971-8980	JJ	denotes	different
T6690	8981-8985	IN	denotes	from
T6691	8986-8990	DT	denotes	that
T6692	8991-8993	IN	denotes	of
T6693	8994-8995	-LRB-	denotes	(
T6695	8995-8996	SYM	denotes	+
T6697	8996-8997	HYPH	denotes	/
T6696	8997-8998	SYM	denotes	+
T6698	8998-8999	-RRB-	denotes	)
T6694	9000-9004	NNS	denotes	mice
T6699	9005-9007	IN	denotes	at
T6700	9008-9009	CD	denotes	0
T6701	9010-9013	NN	denotes	rpm
T6702	9014-9015	-LRB-	denotes	(
T6703	9015-9025	JJ	denotes	stationary
T6704	9025-9026	-RRB-	denotes	)
T6705	9027-9028	-LRB-	denotes	[
T6707	9028-9029	SYM	denotes	+
T6709	9029-9030	HYPH	denotes	/
T6708	9030-9031	SYM	denotes	-
T6711	9031-9033	:	denotes	:
T6712	9033-9034	NN	denotes	F
T6714	9035-9036	-LRB-	denotes	(
T6715	9036-9037	CD	denotes	1
T6716	9037-9039	,	denotes	,
T6717	9039-9041	CD	denotes	80
T6718	9041-9042	-RRB-	denotes	)
T6719	9043-9044	SYM	denotes	=
T6713	9045-9049	CD	denotes	1.67
T6720	9049-9051	,	denotes	,
T6721	9051-9052	NN	denotes	p
T6722	9053-9054	SYM	denotes	=
T6710	9055-9059	CD	denotes	0.21
T6723	9059-9060	:	denotes	;
T6724	9061-9062	SYM	denotes	-
T6726	9062-9063	HYPH	denotes	/
T6725	9063-9064	SYM	denotes	-
T6727	9064-9066	:	denotes	:
T6728	9066-9067	NN	denotes	F
T6730	9068-9069	-LRB-	denotes	(
T6731	9069-9070	CD	denotes	1
T6732	9070-9072	,	denotes	,
T6733	9072-9074	CD	denotes	88
T6734	9074-9075	-RRB-	denotes	)
T6735	9076-9077	SYM	denotes	=
T6729	9078-9083	CD	denotes	0.002
T6736	9083-9085	,	denotes	,
T6737	9085-9086	NN	denotes	p
T6738	9087-9088	SYM	denotes	=
T6706	9089-9093	CD	denotes	0.96
T6739	9093-9094	-RRB-	denotes	]
T6740	9095-9096	-LRB-	denotes	(
T6742	9096-9100	NN	denotes	Fig.
T6741	9101-9103	NN	denotes	3A
T6743	9103-9104	-RRB-	denotes	)
T6744	9104-9105	.	denotes	.
T6745	9105-9393	sentence	denotes	In (+/-) mice, the tendency of decreased retention times was seen at 5, 10 and 15 rpm, but there was no significant difference between (+/+) and (+/-) mice [5 rpm: F (1, 20) = 1.27, p = 0.27; 10 rpm: F (1, 20) = 1.07, p = 0.31; 15 rpm: F (1, 20) = 2.716, p = 0.11] (Figs. 3B, 3C and 3D).
T6746	9106-9108	IN	denotes	In
T6748	9109-9110	-LRB-	denotes	(
T6750	9110-9111	SYM	denotes	+
T6752	9111-9112	HYPH	denotes	/
T6751	9112-9113	SYM	denotes	-
T6753	9113-9114	-RRB-	denotes	)
T6749	9115-9119	NNS	denotes	mice
T6754	9119-9121	,	denotes	,
T6755	9121-9124	DT	denotes	the
T6756	9125-9133	NN	denotes	tendency
T6757	9134-9136	IN	denotes	of
T6758	9137-9146	VBN	denotes	decreased
T6760	9147-9156	NN	denotes	retention
T6759	9157-9162	NNS	denotes	times
T6761	9163-9166	VBD	denotes	was
T6747	9167-9171	VBN	denotes	seen
T6762	9172-9174	IN	denotes	at
T6763	9175-9176	CD	denotes	5
T6765	9176-9178	,	denotes	,
T6766	9178-9180	CD	denotes	10
T6767	9181-9184	CC	denotes	and
T6768	9185-9187	CD	denotes	15
T6764	9188-9191	NN	denotes	rpm
T6769	9191-9193	,	denotes	,
T6770	9193-9196	CC	denotes	but
T6771	9197-9202	EX	denotes	there
T6772	9203-9206	VBD	denotes	was
T6773	9207-9209	DT	denotes	no
T6775	9210-9221	JJ	denotes	significant
T6774	9222-9232	NN	denotes	difference
T6776	9233-9240	IN	denotes	between
T6777	9241-9242	-LRB-	denotes	(
T6779	9242-9243	SYM	denotes	+
T6781	9243-9244	HYPH	denotes	/
T6780	9244-9245	SYM	denotes	+
T6782	9245-9246	-RRB-	denotes	)
T6783	9247-9250	CC	denotes	and
T6784	9251-9252	-LRB-	denotes	(
T6786	9252-9253	SYM	denotes	+
T6787	9253-9254	HYPH	denotes	/
T6785	9254-9255	SYM	denotes	-
T6788	9255-9256	-RRB-	denotes	)
T6778	9257-9261	NNS	denotes	mice
T6789	9262-9263	-LRB-	denotes	[
T6791	9263-9264	CD	denotes	5
T6792	9265-9268	NN	denotes	rpm
T6794	9268-9270	:	denotes	:
T6795	9270-9271	NN	denotes	F
T6797	9272-9273	-LRB-	denotes	(
T6798	9273-9274	CD	denotes	1
T6799	9274-9276	,	denotes	,
T6800	9276-9278	CD	denotes	20
T6801	9278-9279	-RRB-	denotes	)
T6802	9280-9281	SYM	denotes	=
T6796	9282-9286	CD	denotes	1.27
T6803	9286-9288	,	denotes	,
T6804	9288-9289	NN	denotes	p
T6805	9290-9291	SYM	denotes	=
T6793	9292-9296	CD	denotes	0.27
T6806	9296-9297	:	denotes	;
T6807	9298-9300	CD	denotes	10
T6808	9301-9304	NN	denotes	rpm
T6810	9304-9306	:	denotes	:
T6811	9306-9307	NN	denotes	F
T6813	9308-9309	-LRB-	denotes	(
T6814	9309-9310	CD	denotes	1
T6815	9310-9312	,	denotes	,
T6816	9312-9314	CD	denotes	20
T6817	9314-9315	-RRB-	denotes	)
T6818	9316-9317	SYM	denotes	=
T6812	9318-9322	CD	denotes	1.07
T6819	9322-9324	,	denotes	,
T6820	9324-9325	NN	denotes	p
T6821	9326-9327	SYM	denotes	=
T6809	9328-9332	CD	denotes	0.31
T6822	9332-9333	:	denotes	;
T6823	9334-9336	CD	denotes	15
T6824	9337-9340	NN	denotes	rpm
T6825	9340-9342	:	denotes	:
T6826	9342-9343	NN	denotes	F
T6828	9344-9345	-LRB-	denotes	(
T6829	9345-9346	CD	denotes	1
T6830	9346-9348	,	denotes	,
T6831	9348-9350	CD	denotes	20
T6832	9350-9351	-RRB-	denotes	)
T6833	9352-9353	SYM	denotes	=
T6827	9354-9359	CD	denotes	2.716
T6834	9359-9361	,	denotes	,
T6835	9361-9362	NN	denotes	p
T6836	9363-9364	SYM	denotes	=
T6790	9365-9369	CD	denotes	0.11
T6837	9369-9370	-RRB-	denotes	]
T6838	9371-9372	-LRB-	denotes	(
T6840	9372-9377	NNS	denotes	Figs.
T6839	9378-9380	NN	denotes	3B
T6841	9380-9382	,	denotes	,
T6842	9382-9384	NN	denotes	3C
T6843	9385-9388	CC	denotes	and
T6844	9389-9391	NN	denotes	3D
T6845	9391-9392	-RRB-	denotes	)
T6846	9392-9393	.	denotes	.
T6847	9393-9621	sentence	denotes	However, (-/-) mice fell more quickly from the rod than (+/+) mice at 5, 10 and 15 rpm [5 rpm: F (1, 27.3) = 17.51, p = 0.0002; 10 rpm: F (1, 22) = 11.05, p = 0.003; 15 rpm: F (1, 22) = 19.22, p = 0.0002] (Figs. 3B, 3C and 3D).
T6848	9394-9401	RB	denotes	However
T6850	9401-9403	,	denotes	,
T6851	9403-9404	-LRB-	denotes	(
T6853	9404-9405	SYM	denotes	-
T6855	9405-9406	HYPH	denotes	/
T6854	9406-9407	SYM	denotes	-
T6856	9407-9408	-RRB-	denotes	)
T6852	9409-9413	NNS	denotes	mice
T6849	9414-9418	VBD	denotes	fell
T6857	9419-9423	RBR	denotes	more
T6858	9424-9431	RB	denotes	quickly
T6859	9432-9436	IN	denotes	from
T6860	9437-9440	DT	denotes	the
T6861	9441-9444	NN	denotes	rod
T6862	9445-9449	IN	denotes	than
T6863	9450-9451	-LRB-	denotes	(
T6864	9451-9452	SYM	denotes	+
T6866	9452-9453	HYPH	denotes	/
T6865	9453-9454	SYM	denotes	+
T6868	9454-9455	-RRB-	denotes	)
T6867	9456-9460	NNS	denotes	mice
T6869	9461-9463	IN	denotes	at
T6870	9464-9465	CD	denotes	5
T6872	9465-9467	,	denotes	,
T6873	9467-9469	CD	denotes	10
T6874	9470-9473	CC	denotes	and
T6875	9474-9476	CD	denotes	15
T6871	9477-9480	NN	denotes	rpm
T6876	9481-9482	-LRB-	denotes	[
T6878	9482-9483	CD	denotes	5
T6879	9484-9487	NN	denotes	rpm
T6881	9487-9489	:	denotes	:
T6882	9489-9490	NN	denotes	F
T6884	9491-9492	-LRB-	denotes	(
T6885	9492-9493	CD	denotes	1
T6886	9493-9495	,	denotes	,
T6887	9495-9499	CD	denotes	27.3
T6888	9499-9500	-RRB-	denotes	)
T6889	9501-9502	SYM	denotes	=
T6883	9503-9508	CD	denotes	17.51
T6890	9508-9510	,	denotes	,
T6891	9510-9511	NN	denotes	p
T6892	9512-9513	SYM	denotes	=
T6880	9514-9520	CD	denotes	0.0002
T6893	9520-9521	:	denotes	;
T6894	9522-9524	CD	denotes	10
T6895	9525-9528	NN	denotes	rpm
T6897	9528-9530	:	denotes	:
T6898	9530-9531	NN	denotes	F
T6900	9532-9533	-LRB-	denotes	(
T6901	9533-9534	CD	denotes	1
T6902	9534-9536	,	denotes	,
T6903	9536-9538	CD	denotes	22
T6904	9538-9539	-RRB-	denotes	)
T6905	9540-9541	SYM	denotes	=
T6899	9542-9547	CD	denotes	11.05
T6906	9547-9549	,	denotes	,
T6907	9549-9550	NN	denotes	p
T6908	9551-9552	SYM	denotes	=
T6896	9553-9558	CD	denotes	0.003
T6909	9558-9559	:	denotes	;
T6910	9560-9562	CD	denotes	15
T6911	9563-9566	NN	denotes	rpm
T6912	9566-9568	:	denotes	:
T6913	9568-9569	NN	denotes	F
T6915	9570-9571	-LRB-	denotes	(
T6916	9571-9572	CD	denotes	1
T6917	9572-9574	,	denotes	,
T6918	9574-9576	CD	denotes	22
T6919	9576-9577	-RRB-	denotes	)
T6920	9578-9579	SYM	denotes	=
T6914	9580-9585	CD	denotes	19.22
T6921	9585-9587	,	denotes	,
T6922	9587-9588	NN	denotes	p
T6923	9589-9590	SYM	denotes	=
T6877	9591-9597	CD	denotes	0.0002
T6924	9597-9598	-RRB-	denotes	]
T6925	9599-9600	-LRB-	denotes	(
T6927	9600-9605	NNS	denotes	Figs.
T6926	9606-9608	NN	denotes	3B
T6928	9608-9610	,	denotes	,
T6929	9610-9612	NN	denotes	3C
T6930	9613-9616	CC	denotes	and
T6931	9617-9619	NN	denotes	3D
T6932	9619-9620	-RRB-	denotes	)
T6933	9620-9621	.	denotes	.
T6934	9621-9867	sentence	denotes	The retention time was not significantly improved in (-/-) mice across trials of training at 5, 10 and 15 rpm [5 rpm: F (3, 15.3) = 2.05, p = 0.15; 10 rpm: F (7, 11) = 2.61, p = 0.07; 15 rpm: F (19, 26.6) = 1.57, p = 0.14] (Figs. 3B, 3C and 3D).
T6935	9622-9625	DT	denotes	The
T6937	9626-9635	NN	denotes	retention
T6936	9636-9640	NN	denotes	time
T6939	9641-9644	VBD	denotes	was
T6940	9645-9648	RB	denotes	not
T6941	9649-9662	RB	denotes	significantly
T6938	9663-9671	VBN	denotes	improved
T6942	9672-9674	IN	denotes	in
T6943	9675-9676	-LRB-	denotes	(
T6945	9676-9677	SYM	denotes	-
T6947	9677-9678	HYPH	denotes	/
T6946	9678-9679	SYM	denotes	-
T6948	9679-9680	-RRB-	denotes	)
T6944	9681-9685	NNS	denotes	mice
T6949	9686-9692	IN	denotes	across
T6950	9693-9699	NNS	denotes	trials
T6951	9700-9702	IN	denotes	of
T6952	9703-9711	NN	denotes	training
T6953	9712-9714	IN	denotes	at
T6954	9715-9716	CD	denotes	5
T6956	9716-9718	,	denotes	,
T6957	9718-9720	CD	denotes	10
T6958	9721-9724	CC	denotes	and
T6959	9725-9727	CD	denotes	15
T6955	9728-9731	NN	denotes	rpm
T6960	9732-9733	-LRB-	denotes	[
T6962	9733-9734	CD	denotes	5
T6963	9735-9738	NN	denotes	rpm
T6965	9738-9740	:	denotes	:
T6966	9740-9741	NN	denotes	F
T6968	9742-9743	-LRB-	denotes	(
T6969	9743-9744	CD	denotes	3
T6970	9744-9746	,	denotes	,
T6971	9746-9750	CD	denotes	15.3
T6972	9750-9751	-RRB-	denotes	)
T6973	9752-9753	SYM	denotes	=
T6967	9754-9758	CD	denotes	2.05
T6974	9758-9760	,	denotes	,
T6975	9760-9761	NN	denotes	p
T6976	9762-9763	SYM	denotes	=
T6964	9764-9768	CD	denotes	0.15
T6977	9768-9769	:	denotes	;
T6978	9770-9772	CD	denotes	10
T6979	9773-9776	NN	denotes	rpm
T6981	9776-9778	:	denotes	:
T6982	9778-9779	NN	denotes	F
T6984	9780-9781	-LRB-	denotes	(
T6985	9781-9782	CD	denotes	7
T6986	9782-9784	,	denotes	,
T6987	9784-9786	CD	denotes	11
T6988	9786-9787	-RRB-	denotes	)
T6989	9788-9789	SYM	denotes	=
T6983	9790-9794	CD	denotes	2.61
T6990	9794-9796	,	denotes	,
T6991	9796-9797	NN	denotes	p
T6992	9798-9799	SYM	denotes	=
T6980	9800-9804	CD	denotes	0.07
T6993	9804-9805	:	denotes	;
T6994	9806-9808	CD	denotes	15
T6995	9809-9812	NN	denotes	rpm
T6996	9812-9814	:	denotes	:
T6997	9814-9815	NN	denotes	F
T6999	9816-9817	-LRB-	denotes	(
T7000	9817-9819	CD	denotes	19
T7001	9819-9821	,	denotes	,
T7002	9821-9825	CD	denotes	26.6
T7003	9825-9826	-RRB-	denotes	)
T7004	9827-9828	SYM	denotes	=
T6998	9829-9833	CD	denotes	1.57
T7005	9833-9835	,	denotes	,
T7006	9835-9836	NN	denotes	p
T7007	9837-9838	SYM	denotes	=
T6961	9839-9843	CD	denotes	0.14
T7008	9843-9844	-RRB-	denotes	]
T7009	9845-9846	-LRB-	denotes	(
T7011	9846-9851	NNS	denotes	Figs.
T7010	9852-9854	NN	denotes	3B
T7012	9854-9856	,	denotes	,
T7013	9856-9858	NN	denotes	3C
T7014	9859-9862	CC	denotes	and
T7015	9863-9865	NN	denotes	3D
T7016	9865-9866	-RRB-	denotes	)
T7017	9866-9867	.	denotes	.
T7018	9867-9976	sentence	denotes	In a traction test, (-/-) mice showed a high grip strength similar to that of (+/+) and (+/-) mice (Fig. 4).
T7019	9868-9870	IN	denotes	In
T7021	9871-9872	DT	denotes	a
T7023	9873-9881	NN	denotes	traction
T7022	9882-9886	NN	denotes	test
T7024	9886-9888	,	denotes	,
T7025	9888-9889	-LRB-	denotes	(
T7027	9889-9890	SYM	denotes	-
T7029	9890-9891	HYPH	denotes	/
T7028	9891-9892	SYM	denotes	-
T7030	9892-9893	-RRB-	denotes	)
T7026	9894-9898	NNS	denotes	mice
T7020	9899-9905	VBD	denotes	showed
T7031	9906-9907	DT	denotes	a
T7033	9908-9912	JJ	denotes	high
T7034	9913-9917	NN	denotes	grip
T7032	9918-9926	NN	denotes	strength
T7035	9927-9934	JJ	denotes	similar
T7036	9935-9937	IN	denotes	to
T7037	9938-9942	DT	denotes	that
T7038	9943-9945	IN	denotes	of
T7039	9946-9947	-LRB-	denotes	(
T7041	9947-9948	SYM	denotes	+
T7043	9948-9949	HYPH	denotes	/
T7042	9949-9950	SYM	denotes	+
T7044	9950-9951	-RRB-	denotes	)
T7045	9952-9955	CC	denotes	and
T7046	9956-9957	-LRB-	denotes	(
T7048	9957-9958	SYM	denotes	+
T7049	9958-9959	HYPH	denotes	/
T7047	9959-9960	SYM	denotes	-
T7050	9960-9961	-RRB-	denotes	)
T7040	9962-9966	NNS	denotes	mice
T7051	9967-9968	-LRB-	denotes	(
T7052	9968-9972	NN	denotes	Fig.
T7053	9973-9974	CD	denotes	4
T7054	9974-9975	-RRB-	denotes	)
T7055	9975-9976	.	denotes	.
T7056	9976-10087	sentence	denotes	The hanging score and time of (-/-) mice were also similar to those of (+/+) and (+/-) mice (Figs. 5A and 5B).
T7057	9977-9980	DT	denotes	The
T7059	9981-9988	VBG	denotes	hanging
T7058	9989-9994	NN	denotes	score
T7061	9995-9998	CC	denotes	and
T7062	9999-10003	NN	denotes	time
T7063	10004-10006	IN	denotes	of
T7064	10007-10008	-LRB-	denotes	(
T7066	10008-10009	SYM	denotes	-
T7068	10009-10010	HYPH	denotes	/
T7067	10010-10011	SYM	denotes	-
T7069	10011-10012	-RRB-	denotes	)
T7065	10013-10017	NNS	denotes	mice
T7060	10018-10022	VBD	denotes	were
T7070	10023-10027	RB	denotes	also
T7071	10028-10035	JJ	denotes	similar
T7072	10036-10038	IN	denotes	to
T7073	10039-10044	DT	denotes	those
T7074	10045-10047	IN	denotes	of
T7075	10048-10049	-LRB-	denotes	(
T7077	10049-10050	SYM	denotes	+
T7079	10050-10051	HYPH	denotes	/
T7078	10051-10052	SYM	denotes	+
T7080	10052-10053	-RRB-	denotes	)
T7081	10054-10057	CC	denotes	and
T7082	10058-10059	-LRB-	denotes	(
T7084	10059-10060	SYM	denotes	+
T7085	10060-10061	HYPH	denotes	/
T7083	10061-10062	SYM	denotes	-
T7086	10062-10063	-RRB-	denotes	)
T7076	10064-10068	NNS	denotes	mice
T7087	10069-10070	-LRB-	denotes	(
T7089	10070-10075	NNS	denotes	Figs.
T7088	10076-10078	NN	denotes	5A
T7090	10079-10082	CC	denotes	and
T7091	10083-10085	NN	denotes	5B
T7092	10085-10086	-RRB-	denotes	)
T7093	10086-10087	.	denotes	.
T7094	10087-10244	sentence	denotes	A footprint test did not reveal any abnormalities in walking patterns, including stride length and step width, as a function of genotypes (Figs. 6A and 6B).
T7095	10088-10089	DT	denotes	A
T7097	10090-10099	NN	denotes	footprint
T7096	10100-10104	NN	denotes	test
T7099	10105-10108	VBD	denotes	did
T7100	10109-10112	RB	denotes	not
T7098	10113-10119	VB	denotes	reveal
T7101	10120-10123	DT	denotes	any
T7102	10124-10137	NNS	denotes	abnormalities
T7103	10138-10140	IN	denotes	in
T7104	10141-10148	VBG	denotes	walking
T7105	10149-10157	NNS	denotes	patterns
T7106	10157-10159	,	denotes	,
T7107	10159-10168	VBG	denotes	including
T7108	10169-10175	NN	denotes	stride
T7109	10176-10182	NN	denotes	length
T7110	10183-10186	CC	denotes	and
T7111	10187-10191	NN	denotes	step
T7112	10192-10197	NN	denotes	width
T7113	10197-10199	,	denotes	,
T7114	10199-10201	IN	denotes	as
T7115	10202-10203	DT	denotes	a
T7116	10204-10212	NN	denotes	function
T7117	10213-10215	IN	denotes	of
T7118	10216-10225	NNS	denotes	genotypes
T7119	10226-10227	-LRB-	denotes	(
T7121	10227-10232	NNS	denotes	Figs.
T7120	10233-10235	NN	denotes	6A
T7122	10236-10239	CC	denotes	and
T7123	10240-10242	NN	denotes	6B
T7124	10242-10243	-RRB-	denotes	)
T7125	10243-10244	.	denotes	.
T9981	10257-10259	IN	denotes	In
T9983	10260-10263	DT	denotes	the
T9985	10264-10271	JJ	denotes	present
T9984	10272-10277	NN	denotes	study
T9986	10277-10279	,	denotes	,
T9987	10279-10281	PRP	denotes	we
T9982	10282-10290	VBD	denotes	examined
T9988	10291-10294	DT	denotes	the
T9989	10295-10303	NN	denotes	function
T9990	10304-10306	IN	denotes	of
T9991	10307-10313	NN	denotes	ADAM11
T9992	10314-10316	IN	denotes	by
T9993	10317-10327	VBG	denotes	generating
T9994	10328-10332	NNS	denotes	mice
T9995	10333-10337	WDT	denotes	that
T9996	10338-10344	VBD	denotes	lacked
T9997	10345-10348	DT	denotes	the
T9999	10349-10355	NN	denotes	Adam11
T9998	10356-10360	NN	denotes	gene
T10000	10360-10361	.	denotes	.
T10001	10361-10501	sentence	denotes	It has been reported that the Adam11 gene is expressed in the brain, heart, liver and testis, as manifested in Northern blot analysis [19].
T10002	10362-10364	PRP	denotes	It
T10004	10365-10368	VBZ	denotes	has
T10005	10369-10373	VBN	denotes	been
T10003	10374-10382	VBN	denotes	reported
T10006	10383-10387	IN	denotes	that
T10008	10388-10391	DT	denotes	the
T10010	10392-10398	NN	denotes	Adam11
T10009	10399-10403	NN	denotes	gene
T10011	10404-10406	VBZ	denotes	is
T10007	10407-10416	VBN	denotes	expressed
T10012	10417-10419	IN	denotes	in
T10013	10420-10423	DT	denotes	the
T10014	10424-10429	NN	denotes	brain
T10015	10429-10431	,	denotes	,
T10016	10431-10436	NN	denotes	heart
T10017	10436-10438	,	denotes	,
T10018	10438-10443	NN	denotes	liver
T10019	10444-10447	CC	denotes	and
T10020	10448-10454	NN	denotes	testis
T10021	10454-10456	,	denotes	,
T10022	10456-10458	IN	denotes	as
T10023	10459-10469	VBN	denotes	manifested
T10024	10470-10472	IN	denotes	in
T10025	10473-10481	NNP	denotes	Northern
T10026	10482-10486	NN	denotes	blot
T10027	10487-10495	NN	denotes	analysis
T10028	10496-10497	-LRB-	denotes	[
T10029	10497-10499	CD	denotes	19
T10030	10499-10500	-RRB-	denotes	]
T10031	10500-10501	.	denotes	.
T10032	10501-10675	sentence	denotes	Interestingly, ADAM11-deficient mice appeared normal and survived more than one year without apparent histological abnormality, including the brain, heart, liver and testis.
T10033	10502-10515	RB	denotes	Interestingly
T10035	10515-10517	,	denotes	,
T10036	10517-10523	NN	denotes	ADAM11
T10038	10523-10524	HYPH	denotes	-
T10037	10524-10533	JJ	denotes	deficient
T10039	10534-10538	NNS	denotes	mice
T10034	10539-10547	VBD	denotes	appeared
T10040	10548-10554	JJ	denotes	normal
T10041	10555-10558	CC	denotes	and
T10042	10559-10567	VBD	denotes	survived
T10043	10568-10572	JJR	denotes	more
T10045	10573-10577	IN	denotes	than
T10044	10578-10581	CD	denotes	one
T10046	10582-10586	NN	denotes	year
T10047	10587-10594	IN	denotes	without
T10048	10595-10603	JJ	denotes	apparent
T10050	10604-10616	JJ	denotes	histological
T10049	10617-10628	NN	denotes	abnormality
T10051	10628-10630	,	denotes	,
T10052	10630-10639	VBG	denotes	including
T10053	10640-10643	DT	denotes	the
T10054	10644-10649	NN	denotes	brain
T10055	10649-10651	,	denotes	,
T10056	10651-10656	NN	denotes	heart
T10057	10656-10658	,	denotes	,
T10058	10658-10663	NN	denotes	liver
T10059	10664-10667	CC	denotes	and
T10060	10668-10674	NN	denotes	testis
T10061	10674-10675	.	denotes	.
T10062	10675-10783	sentence	denotes	The expression patterns of the Adam11 gene in the brain have been studied using in situ hybridisation [25].
T10063	10676-10679	DT	denotes	The
T10065	10680-10690	NN	denotes	expression
T10064	10691-10699	NNS	denotes	patterns
T10067	10700-10702	IN	denotes	of
T10068	10703-10706	DT	denotes	the
T10070	10707-10713	NN	denotes	Adam11
T10069	10714-10718	NN	denotes	gene
T10071	10719-10721	IN	denotes	in
T10072	10722-10725	DT	denotes	the
T10073	10726-10731	NN	denotes	brain
T10074	10732-10736	VBP	denotes	have
T10075	10737-10741	VBN	denotes	been
T10066	10742-10749	VBN	denotes	studied
T10076	10750-10755	VBG	denotes	using
T10077	10756-10758	FW	denotes	in
T10078	10759-10763	FW	denotes	situ
T10079	10764-10777	NN	denotes	hybridisation
T10080	10778-10779	-LRB-	denotes	[
T10081	10779-10781	CD	denotes	25
T10082	10781-10782	-RRB-	denotes	]
T10083	10782-10783	.	denotes	.
T10084	10783-10870	sentence	denotes	This study has shown high expression of ADAM11 mRNA in the hippocampus and cerebellum.
T10085	10784-10788	DT	denotes	This
T10086	10789-10794	NN	denotes	study
T10088	10795-10798	VBZ	denotes	has
T10087	10799-10804	VBN	denotes	shown
T10089	10805-10809	JJ	denotes	high
T10090	10810-10820	NN	denotes	expression
T10091	10821-10823	IN	denotes	of
T10092	10824-10830	NN	denotes	ADAM11
T10093	10831-10835	NN	denotes	mRNA
T10094	10836-10838	IN	denotes	in
T10095	10839-10842	DT	denotes	the
T10096	10843-10854	NN	denotes	hippocampus
T10097	10855-10858	CC	denotes	and
T10098	10859-10869	NN	denotes	cerebellum
T10099	10869-10870	.	denotes	.
T10100	10870-11020	sentence	denotes	We therefore focused on examining the hippocampus- and cerebellum-dependent behavioural tests to study the functions of ADAM11 in the nervous system.
T10101	10871-10873	PRP	denotes	We
T10103	10874-10883	RB	denotes	therefore
T10102	10884-10891	VBD	denotes	focused
T10104	10892-10894	IN	denotes	on
T10105	10895-10904	VBG	denotes	examining
T10106	10905-10908	DT	denotes	the
T10108	10909-10920	NN	denotes	hippocampus
T10110	10920-10921	HYPH	denotes	-
T10111	10922-10925	CC	denotes	and
T10112	10926-10936	NN	denotes	cerebellum
T10113	10936-10937	HYPH	denotes	-
T10109	10937-10946	JJ	denotes	dependent
T10114	10947-10958	JJ	denotes	behavioural
T10107	10959-10964	NNS	denotes	tests
T10115	10965-10967	TO	denotes	to
T10116	10968-10973	VB	denotes	study
T10117	10974-10977	DT	denotes	the
T10118	10978-10987	NNS	denotes	functions
T10119	10988-10990	IN	denotes	of
T10120	10991-10997	NN	denotes	ADAM11
T10121	10998-11000	IN	denotes	in
T10122	11001-11004	DT	denotes	the
T10124	11005-11012	JJ	denotes	nervous
T10123	11013-11019	NN	denotes	system
T10125	11019-11020	.	denotes	.
T10126	11020-11250	sentence	denotes	It is widely accepted that the hippocampus is involved in the performance of the hidden platform version of the water maze test, since lesions of the hippocampal pathways lead to a severe impairment of learning in this task [29].
T10127	11021-11023	PRP	denotes	It
T10129	11024-11026	VBZ	denotes	is
T10130	11027-11033	RB	denotes	widely
T10128	11034-11042	VBN	denotes	accepted
T10131	11043-11047	IN	denotes	that
T10133	11048-11051	DT	denotes	the
T10134	11052-11063	NN	denotes	hippocampus
T10135	11064-11066	VBZ	denotes	is
T10132	11067-11075	VBN	denotes	involved
T10136	11076-11078	IN	denotes	in
T10137	11079-11082	DT	denotes	the
T10138	11083-11094	NN	denotes	performance
T10139	11095-11097	IN	denotes	of
T10140	11098-11101	DT	denotes	the
T10142	11102-11108	JJ	denotes	hidden
T10143	11109-11117	NN	denotes	platform
T10141	11118-11125	NN	denotes	version
T10144	11126-11128	IN	denotes	of
T10145	11129-11132	DT	denotes	the
T10147	11133-11138	NN	denotes	water
T10148	11139-11143	NN	denotes	maze
T10146	11144-11148	NN	denotes	test
T10149	11148-11150	,	denotes	,
T10150	11150-11155	IN	denotes	since
T10152	11156-11163	NNS	denotes	lesions
T10153	11164-11166	IN	denotes	of
T10154	11167-11170	DT	denotes	the
T10156	11171-11182	JJ	denotes	hippocampal
T10155	11183-11191	NNS	denotes	pathways
T10151	11192-11196	VBP	denotes	lead
T10157	11197-11199	IN	denotes	to
T10158	11200-11201	DT	denotes	a
T10160	11202-11208	JJ	denotes	severe
T10159	11209-11219	NN	denotes	impairment
T10161	11220-11222	IN	denotes	of
T10162	11223-11231	VBG	denotes	learning
T10163	11232-11234	IN	denotes	in
T10164	11235-11239	DT	denotes	this
T10165	11240-11244	NN	denotes	task
T10166	11245-11246	-LRB-	denotes	[
T10167	11246-11248	CD	denotes	29
T10168	11248-11249	-RRB-	denotes	]
T10169	11249-11250	.	denotes	.
T10170	11250-11361	sentence	denotes	In the hidden platform task, ADAM11-deficient mice needed more time to reach the platform than wild-type mice.
T10171	11251-11253	IN	denotes	In
T10173	11254-11257	DT	denotes	the
T10175	11258-11264	JJ	denotes	hidden
T10176	11265-11273	NN	denotes	platform
T10174	11274-11278	NN	denotes	task
T10177	11278-11280	,	denotes	,
T10178	11280-11286	NN	denotes	ADAM11
T10180	11286-11287	HYPH	denotes	-
T10179	11287-11296	JJ	denotes	deficient
T10181	11297-11301	NNS	denotes	mice
T10172	11302-11308	VBD	denotes	needed
T10182	11309-11313	JJR	denotes	more
T10183	11314-11318	NN	denotes	time
T10184	11319-11321	TO	denotes	to
T10185	11322-11327	VB	denotes	reach
T10186	11328-11331	DT	denotes	the
T10187	11332-11340	NN	denotes	platform
T10188	11341-11345	IN	denotes	than
T10189	11346-11350	JJ	denotes	wild
T10191	11350-11351	HYPH	denotes	-
T10190	11351-11355	NN	denotes	type
T10192	11356-11360	NNS	denotes	mice
T10193	11360-11361	.	denotes	.
T10194	11361-11509	sentence	denotes	Spatial learning was also assessed using a probe trial, in which the platform was removed from the pool on the day following nine days of training.
T10195	11362-11369	JJ	denotes	Spatial
T10196	11370-11378	NN	denotes	learning
T10198	11379-11382	VBD	denotes	was
T10199	11383-11387	RB	denotes	also
T10197	11388-11396	VBN	denotes	assessed
T10200	11397-11402	VBG	denotes	using
T10201	11403-11404	DT	denotes	a
T10203	11405-11410	NN	denotes	probe
T10202	11411-11416	NN	denotes	trial
T10204	11416-11418	,	denotes	,
T10205	11418-11420	IN	denotes	in
T10207	11421-11426	WDT	denotes	which
T10208	11427-11430	DT	denotes	the
T10209	11431-11439	NN	denotes	platform
T10210	11440-11443	VBD	denotes	was
T10206	11444-11451	VBN	denotes	removed
T10211	11452-11456	IN	denotes	from
T10212	11457-11460	DT	denotes	the
T10213	11461-11465	NN	denotes	pool
T10214	11466-11468	IN	denotes	on
T10215	11469-11472	DT	denotes	the
T10216	11473-11476	NN	denotes	day
T10217	11477-11486	VBG	denotes	following
T10218	11487-11491	CD	denotes	nine
T10219	11492-11496	NNS	denotes	days
T10220	11497-11499	IN	denotes	of
T10221	11500-11508	NN	denotes	training
T10222	11508-11509	.	denotes	.
T10223	11509-11634	sentence	denotes	The wild-type mice spent significantly more time searching for the platform in the target quadrant than the other quadrants.
T10224	11510-11513	DT	denotes	The
T10226	11514-11518	JJ	denotes	wild
T10228	11518-11519	HYPH	denotes	-
T10227	11519-11523	NN	denotes	type
T10225	11524-11528	NNS	denotes	mice
T10229	11529-11534	VBD	denotes	spent
T10230	11535-11548	RB	denotes	significantly
T10231	11549-11553	JJR	denotes	more
T10232	11554-11558	NN	denotes	time
T10233	11559-11568	VBG	denotes	searching
T10234	11569-11572	IN	denotes	for
T10235	11573-11576	DT	denotes	the
T10236	11577-11585	NN	denotes	platform
T10237	11586-11588	IN	denotes	in
T10238	11589-11592	DT	denotes	the
T10240	11593-11599	NN	denotes	target
T10239	11600-11608	NN	denotes	quadrant
T10241	11609-11613	IN	denotes	than
T10242	11614-11617	DT	denotes	the
T10244	11618-11623	JJ	denotes	other
T10243	11624-11633	NNS	denotes	quadrants
T10245	11633-11634	.	denotes	.
T10246	11634-11716	sentence	denotes	However, ADAM11-deficient mice did not search selectively in the target quadrant.
T10247	11635-11642	RB	denotes	However
T10249	11642-11644	,	denotes	,
T10250	11644-11650	NN	denotes	ADAM11
T10252	11650-11651	HYPH	denotes	-
T10251	11651-11660	JJ	denotes	deficient
T10253	11661-11665	NNS	denotes	mice
T10254	11666-11669	VBD	denotes	did
T10255	11670-11673	RB	denotes	not
T10248	11674-11680	VB	denotes	search
T10256	11681-11692	RB	denotes	selectively
T10257	11693-11695	IN	denotes	in
T10258	11696-11699	DT	denotes	the
T10260	11700-11706	NN	denotes	target
T10259	11707-11715	NN	denotes	quadrant
T10261	11715-11716	.	denotes	.
T10262	11716-11873	sentence	denotes	On the other hand, in the visible platform version, in which the motor ability and visual acuity of the mouse are tested, ADAM11-defieient mice were normal.
T10263	11717-11719	IN	denotes	On
T10265	11720-11723	DT	denotes	the
T10267	11724-11729	JJ	denotes	other
T10266	11730-11734	NN	denotes	hand
T10268	11734-11736	,	denotes	,
T10269	11736-11738	IN	denotes	in
T10270	11739-11742	DT	denotes	the
T10272	11743-11750	JJ	denotes	visible
T10273	11751-11759	NN	denotes	platform
T10271	11760-11767	NN	denotes	version
T10274	11767-11769	,	denotes	,
T10275	11769-11771	IN	denotes	in
T10277	11772-11777	WDT	denotes	which
T10278	11778-11781	DT	denotes	the
T10280	11782-11787	JJ	denotes	motor
T10279	11788-11795	NN	denotes	ability
T10281	11796-11799	CC	denotes	and
T10282	11800-11806	JJ	denotes	visual
T10283	11807-11813	NN	denotes	acuity
T10284	11814-11816	IN	denotes	of
T10285	11817-11820	DT	denotes	the
T10286	11821-11826	NN	denotes	mouse
T10287	11827-11830	VBP	denotes	are
T10276	11831-11837	VBN	denotes	tested
T10288	11837-11839	,	denotes	,
T10289	11839-11845	NN	denotes	ADAM11
T10291	11845-11846	HYPH	denotes	-
T10290	11846-11855	JJ	denotes	defieient
T10292	11856-11860	NNS	denotes	mice
T10264	11861-11865	VBD	denotes	were
T10293	11866-11872	JJ	denotes	normal
T10294	11872-11873	.	denotes	.
T10295	11873-11962	sentence	denotes	These results indicated that ADAM11-deficient mice showed a spatial learning impairment.
T10296	11874-11879	DT	denotes	These
T10297	11880-11887	NNS	denotes	results
T10298	11888-11897	VBD	denotes	indicated
T10299	11898-11902	IN	denotes	that
T10301	11903-11909	NN	denotes	ADAM11
T10303	11909-11910	HYPH	denotes	-
T10302	11910-11919	JJ	denotes	deficient
T10304	11920-11924	NNS	denotes	mice
T10300	11925-11931	VBD	denotes	showed
T10305	11932-11933	DT	denotes	a
T10307	11934-11941	JJ	denotes	spatial
T10308	11942-11950	NN	denotes	learning
T10306	11951-11961	NN	denotes	impairment
T10309	11961-11962	.	denotes	.
T10310	11962-12132	sentence	denotes	The cerebellum is in charge of the smooth coordination of somatic motor activity, regulation of muscle tone, and mechanisms that influence and maintain equilibrium [30].
T10311	11963-11966	DT	denotes	The
T10312	11967-11977	NN	denotes	cerebellum
T10313	11978-11980	VBZ	denotes	is
T10314	11981-11983	IN	denotes	in
T10315	11984-11990	NN	denotes	charge
T10316	11991-11993	IN	denotes	of
T10317	11994-11997	DT	denotes	the
T10319	11998-12004	JJ	denotes	smooth
T10318	12005-12017	NN	denotes	coordination
T10320	12018-12020	IN	denotes	of
T10321	12021-12028	JJ	denotes	somatic
T10323	12029-12034	NN	denotes	motor
T10322	12035-12043	NN	denotes	activity
T10324	12043-12045	,	denotes	,
T10325	12045-12055	NN	denotes	regulation
T10326	12056-12058	IN	denotes	of
T10327	12059-12065	NN	denotes	muscle
T10328	12066-12070	NN	denotes	tone
T10329	12070-12072	,	denotes	,
T10330	12072-12075	CC	denotes	and
T10331	12076-12086	NNS	denotes	mechanisms
T10332	12087-12091	WDT	denotes	that
T10333	12092-12101	VBP	denotes	influence
T10334	12102-12105	CC	denotes	and
T10335	12106-12114	VBP	denotes	maintain
T10336	12115-12126	NN	denotes	equilibrium
T10337	12127-12128	-LRB-	denotes	[
T10338	12128-12130	CD	denotes	30
T10339	12130-12131	-RRB-	denotes	]
T10340	12131-12132	.	denotes	.
T10341	12132-12399	sentence	denotes	It is widely accepted that the cerebellum is involved in the performance of the rotating rod task, since mice with structural abnormalities in the cerebellum [31] or with disruptions in genes enriched in the cerebellum [32] exhibit performance deficits in this task.
T10342	12133-12135	PRP	denotes	It
T10344	12136-12138	VBZ	denotes	is
T10345	12139-12145	RB	denotes	widely
T10343	12146-12154	VBN	denotes	accepted
T10346	12155-12159	IN	denotes	that
T10348	12160-12163	DT	denotes	the
T10349	12164-12174	NN	denotes	cerebellum
T10350	12175-12177	VBZ	denotes	is
T10347	12178-12186	VBN	denotes	involved
T10351	12187-12189	IN	denotes	in
T10352	12190-12193	DT	denotes	the
T10353	12194-12205	NN	denotes	performance
T10354	12206-12208	IN	denotes	of
T10355	12209-12212	DT	denotes	the
T10357	12213-12221	VBG	denotes	rotating
T10358	12222-12225	NN	denotes	rod
T10356	12226-12230	NN	denotes	task
T10359	12230-12232	,	denotes	,
T10360	12232-12237	IN	denotes	since
T10362	12238-12242	NNS	denotes	mice
T10363	12243-12247	IN	denotes	with
T10364	12248-12258	JJ	denotes	structural
T10365	12259-12272	NNS	denotes	abnormalities
T10366	12273-12275	IN	denotes	in
T10367	12276-12279	DT	denotes	the
T10368	12280-12290	NN	denotes	cerebellum
T10369	12291-12292	-LRB-	denotes	[
T10370	12292-12294	CD	denotes	31
T10371	12294-12295	-RRB-	denotes	]
T10372	12296-12298	CC	denotes	or
T10373	12299-12303	IN	denotes	with
T10374	12304-12315	NNS	denotes	disruptions
T10375	12316-12318	IN	denotes	in
T10376	12319-12324	NNS	denotes	genes
T10377	12325-12333	VBN	denotes	enriched
T10378	12334-12336	IN	denotes	in
T10379	12337-12340	DT	denotes	the
T10380	12341-12351	NN	denotes	cerebellum
T10381	12352-12353	-LRB-	denotes	[
T10382	12353-12355	CD	denotes	32
T10383	12355-12356	-RRB-	denotes	]
T10361	12357-12364	VBP	denotes	exhibit
T10384	12365-12376	NN	denotes	performance
T10385	12377-12385	NNS	denotes	deficits
T10386	12386-12388	IN	denotes	in
T10387	12389-12393	DT	denotes	this
T10388	12394-12398	NN	denotes	task
T10389	12398-12399	.	denotes	.
T10390	12399-12658	sentence	denotes	In the rotating rod test in this study, although the retention time of ADAM11-deficient mice on the rod was not different from wild-type mice at 0 rpm (stationary), ADAM11-deficient mice fell more quickly from the rod than wild-type mice at 5, 10 and 15 rpm.
T10391	12400-12402	IN	denotes	In
T10393	12403-12406	DT	denotes	the
T10395	12407-12415	VBG	denotes	rotating
T10396	12416-12419	NN	denotes	rod
T10394	12420-12424	NN	denotes	test
T10397	12425-12427	IN	denotes	in
T10398	12428-12432	DT	denotes	this
T10399	12433-12438	NN	denotes	study
T10400	12438-12440	,	denotes	,
T10401	12440-12448	IN	denotes	although
T10403	12449-12452	DT	denotes	the
T10405	12453-12462	NN	denotes	retention
T10404	12463-12467	NN	denotes	time
T10406	12468-12470	IN	denotes	of
T10407	12471-12477	NN	denotes	ADAM11
T10409	12477-12478	HYPH	denotes	-
T10408	12478-12487	JJ	denotes	deficient
T10410	12488-12492	NNS	denotes	mice
T10411	12493-12495	IN	denotes	on
T10412	12496-12499	DT	denotes	the
T10413	12500-12503	NN	denotes	rod
T10402	12504-12507	VBD	denotes	was
T10414	12508-12511	RB	denotes	not
T10415	12512-12521	JJ	denotes	different
T10416	12522-12526	IN	denotes	from
T10417	12527-12531	JJ	denotes	wild
T10419	12531-12532	HYPH	denotes	-
T10418	12532-12536	NN	denotes	type
T10420	12537-12541	NNS	denotes	mice
T10421	12542-12544	IN	denotes	at
T10422	12545-12546	CD	denotes	0
T10423	12547-12550	NN	denotes	rpm
T10424	12551-12552	-LRB-	denotes	(
T10425	12552-12562	JJ	denotes	stationary
T10426	12562-12563	-RRB-	denotes	)
T10427	12563-12565	,	denotes	,
T10428	12565-12571	NN	denotes	ADAM11
T10430	12571-12572	HYPH	denotes	-
T10429	12572-12581	JJ	denotes	deficient
T10431	12582-12586	NNS	denotes	mice
T10392	12587-12591	VBD	denotes	fell
T10432	12592-12596	RBR	denotes	more
T10433	12597-12604	RB	denotes	quickly
T10434	12605-12609	IN	denotes	from
T10435	12610-12613	DT	denotes	the
T10436	12614-12617	NN	denotes	rod
T10437	12618-12622	IN	denotes	than
T10438	12623-12627	JJ	denotes	wild
T10440	12627-12628	HYPH	denotes	-
T10439	12628-12632	NN	denotes	type
T10441	12633-12637	NNS	denotes	mice
T10442	12638-12640	IN	denotes	at
T10443	12641-12642	CD	denotes	5
T10445	12642-12644	,	denotes	,
T10446	12644-12646	CD	denotes	10
T10447	12647-12650	CC	denotes	and
T10448	12651-12653	CD	denotes	15
T10444	12654-12657	NN	denotes	rpm
T10449	12657-12658	.	denotes	.
T10450	12658-12746	sentence	denotes	These results indicate that ADAM11-deficient mice have a deficit in motor coordination.
T10451	12659-12664	DT	denotes	These
T10452	12665-12672	NNS	denotes	results
T10453	12673-12681	VBP	denotes	indicate
T10454	12682-12686	IN	denotes	that
T10456	12687-12693	NN	denotes	ADAM11
T10458	12693-12694	HYPH	denotes	-
T10457	12694-12703	JJ	denotes	deficient
T10459	12704-12708	NNS	denotes	mice
T10455	12709-12713	VBP	denotes	have
T10460	12714-12715	DT	denotes	a
T10461	12716-12723	NN	denotes	deficit
T10462	12724-12726	IN	denotes	in
T10463	12727-12732	NN	denotes	motor
T10464	12733-12745	NN	denotes	coordination
T10465	12745-12746	.	denotes	.
T10466	12746-12884	sentence	denotes	On the other hand, in the visual platform version of the water maze task, motor ability for swimming in ADAM11-deficient mice was normal.
T10467	12747-12749	IN	denotes	On
T10469	12750-12753	DT	denotes	the
T10471	12754-12759	JJ	denotes	other
T10470	12760-12764	NN	denotes	hand
T10472	12764-12766	,	denotes	,
T10473	12766-12768	IN	denotes	in
T10474	12769-12772	DT	denotes	the
T10476	12773-12779	JJ	denotes	visual
T10477	12780-12788	NN	denotes	platform
T10475	12789-12796	NN	denotes	version
T10478	12797-12799	IN	denotes	of
T10479	12800-12803	DT	denotes	the
T10481	12804-12809	NN	denotes	water
T10482	12810-12814	NN	denotes	maze
T10480	12815-12819	NN	denotes	task
T10483	12819-12821	,	denotes	,
T10484	12821-12826	NN	denotes	motor
T10485	12827-12834	NN	denotes	ability
T10486	12835-12838	IN	denotes	for
T10487	12839-12847	NN	denotes	swimming
T10488	12848-12850	IN	denotes	in
T10489	12851-12857	NN	denotes	ADAM11
T10491	12857-12858	HYPH	denotes	-
T10490	12858-12867	JJ	denotes	deficient
T10492	12868-12872	NNS	denotes	mice
T10468	12873-12876	VBD	denotes	was
T10493	12877-12883	JJ	denotes	normal
T10494	12883-12884	.	denotes	.
T10495	12884-13012	sentence	denotes	These results suggested that there might be a different mechanism of motor function between swimming and the rotating rod task.
T10496	12885-12890	DT	denotes	These
T10497	12891-12898	NNS	denotes	results
T10498	12899-12908	VBD	denotes	suggested
T10499	12909-12913	IN	denotes	that
T10501	12914-12919	EX	denotes	there
T10502	12920-12925	MD	denotes	might
T10500	12926-12928	VB	denotes	be
T10503	12929-12930	DT	denotes	a
T10505	12931-12940	JJ	denotes	different
T10504	12941-12950	NN	denotes	mechanism
T10506	12951-12953	IN	denotes	of
T10507	12954-12959	NN	denotes	motor
T10508	12960-12968	NN	denotes	function
T10509	12969-12976	IN	denotes	between
T10510	12977-12985	NN	denotes	swimming
T10511	12986-12989	CC	denotes	and
T10512	12990-12993	DT	denotes	the
T10514	12994-13002	VBG	denotes	rotating
T10515	13003-13006	NN	denotes	rod
T10513	13007-13011	NN	denotes	task
T10516	13011-13012	.	denotes	.
T10517	13012-13177	sentence	denotes	It has been also reported that the cerebellum is involved in another important distinct function: learning associated with component movement (motor learning) [33].
T10518	13013-13015	PRP	denotes	It
T10520	13016-13019	VBZ	denotes	has
T10521	13020-13024	VBN	denotes	been
T10522	13025-13029	RB	denotes	also
T10519	13030-13038	VBN	denotes	reported
T10523	13039-13043	IN	denotes	that
T10525	13044-13047	DT	denotes	the
T10526	13048-13058	NN	denotes	cerebellum
T10527	13059-13061	VBZ	denotes	is
T10524	13062-13070	VBN	denotes	involved
T10528	13071-13073	IN	denotes	in
T10529	13074-13081	DT	denotes	another
T10531	13082-13091	JJ	denotes	important
T10532	13092-13100	JJ	denotes	distinct
T10530	13101-13109	NN	denotes	function
T10533	13109-13111	:	denotes	:
T10534	13111-13119	NN	denotes	learning
T10535	13120-13130	VBN	denotes	associated
T10536	13131-13135	IN	denotes	with
T10537	13136-13145	NN	denotes	component
T10538	13146-13154	NN	denotes	movement
T10539	13155-13156	-LRB-	denotes	(
T10540	13156-13161	NN	denotes	motor
T10541	13162-13170	NN	denotes	learning
T10542	13170-13171	-RRB-	denotes	)
T10543	13172-13173	-LRB-	denotes	[
T10544	13173-13175	CD	denotes	33
T10545	13175-13176	-RRB-	denotes	]
T10546	13176-13177	.	denotes	.
T10547	13177-13408	sentence	denotes	The retention time of synaptotagmin (Syt) IV-deficient mice on the rod was significantly shorter than wild-type mice, and they improved it approximately to the same rates as did wild-type mice during rotating rod performance [34].
T10548	13178-13181	DT	denotes	The
T10550	13182-13191	NN	denotes	retention
T10549	13192-13196	NN	denotes	time
T10552	13197-13199	IN	denotes	of
T10553	13200-13213	NN	denotes	synaptotagmin
T10555	13214-13215	-LRB-	denotes	(
T10556	13215-13218	NN	denotes	Syt
T10558	13218-13219	-RRB-	denotes	)
T10557	13220-13222	NN	denotes	IV
T10559	13222-13223	HYPH	denotes	-
T10554	13223-13232	JJ	denotes	deficient
T10560	13233-13237	NNS	denotes	mice
T10561	13238-13240	IN	denotes	on
T10562	13241-13244	DT	denotes	the
T10563	13245-13248	NN	denotes	rod
T10551	13249-13252	VBD	denotes	was
T10564	13253-13266	RB	denotes	significantly
T10565	13267-13274	JJR	denotes	shorter
T10566	13275-13279	IN	denotes	than
T10567	13280-13284	JJ	denotes	wild
T10569	13284-13285	HYPH	denotes	-
T10568	13285-13289	NN	denotes	type
T10570	13290-13294	NNS	denotes	mice
T10571	13294-13296	,	denotes	,
T10572	13296-13299	CC	denotes	and
T10573	13300-13304	PRP	denotes	they
T10574	13305-13313	VBD	denotes	improved
T10575	13314-13316	PRP	denotes	it
T10576	13317-13330	RB	denotes	approximately
T10577	13331-13333	IN	denotes	to
T10578	13334-13337	DT	denotes	the
T10580	13338-13342	JJ	denotes	same
T10579	13343-13348	NNS	denotes	rates
T10581	13349-13351	IN	denotes	as
T10582	13352-13355	VBD	denotes	did
T10583	13356-13360	JJ	denotes	wild
T10585	13360-13361	HYPH	denotes	-
T10584	13361-13365	NN	denotes	type
T10586	13366-13370	NNS	denotes	mice
T10587	13371-13377	IN	denotes	during
T10588	13378-13386	VBG	denotes	rotating
T10589	13387-13390	NN	denotes	rod
T10590	13391-13402	NN	denotes	performance
T10591	13403-13404	-LRB-	denotes	[
T10592	13404-13406	CD	denotes	34
T10593	13406-13407	-RRB-	denotes	]
T10594	13407-13408	.	denotes	.
T10595	13408-13568	sentence	denotes	These data suggest the basis for the performance deficit on the rotating rod task in the Syt IV mutants is in motor coordination rather than in motor learning.
T10596	13409-13414	DT	denotes	These
T10597	13415-13419	NNS	denotes	data
T10598	13420-13427	VBP	denotes	suggest
T10599	13428-13431	DT	denotes	the
T10600	13432-13437	NN	denotes	basis
T10602	13438-13441	IN	denotes	for
T10603	13442-13445	DT	denotes	the
T10605	13446-13457	NN	denotes	performance
T10604	13458-13465	NN	denotes	deficit
T10606	13466-13468	IN	denotes	on
T10607	13469-13472	DT	denotes	the
T10609	13473-13481	VBG	denotes	rotating
T10610	13482-13485	NN	denotes	rod
T10608	13486-13490	NN	denotes	task
T10611	13491-13493	IN	denotes	in
T10612	13494-13497	DT	denotes	the
T10614	13498-13501	NN	denotes	Syt
T10615	13502-13504	CD	denotes	IV
T10613	13505-13512	NNS	denotes	mutants
T10601	13513-13515	VBZ	denotes	is
T10616	13516-13518	IN	denotes	in
T10617	13519-13524	NN	denotes	motor
T10618	13525-13537	NN	denotes	coordination
T10619	13538-13544	RB	denotes	rather
T10620	13545-13549	IN	denotes	than
T10621	13550-13552	IN	denotes	in
T10622	13553-13558	NN	denotes	motor
T10623	13559-13567	NN	denotes	learning
T10624	13567-13568	.	denotes	.
T10625	13568-13736	sentence	denotes	The results in the present study showed that ADAM11-deficient mice slightly, though not significantly, improved motor learning ability during rotating rod performance.
T10626	13569-13572	DT	denotes	The
T10627	13573-13580	NNS	denotes	results
T10629	13581-13583	IN	denotes	in
T10630	13584-13587	DT	denotes	the
T10632	13588-13595	JJ	denotes	present
T10631	13596-13601	NN	denotes	study
T10628	13602-13608	VBD	denotes	showed
T10633	13609-13613	IN	denotes	that
T10635	13614-13620	NN	denotes	ADAM11
T10637	13620-13621	HYPH	denotes	-
T10636	13621-13630	JJ	denotes	deficient
T10638	13631-13635	NNS	denotes	mice
T10639	13636-13644	RB	denotes	slightly
T10640	13644-13646	,	denotes	,
T10641	13646-13652	IN	denotes	though
T10642	13653-13656	RB	denotes	not
T10643	13657-13670	RB	denotes	significantly
T10644	13670-13672	,	denotes	,
T10634	13672-13680	VBD	denotes	improved
T10645	13681-13686	NN	denotes	motor
T10646	13687-13695	NN	denotes	learning
T10647	13696-13703	NN	denotes	ability
T10648	13704-13710	IN	denotes	during
T10649	13711-13719	VBG	denotes	rotating
T10650	13720-13723	NN	denotes	rod
T10651	13724-13735	NN	denotes	performance
T10652	13735-13736	.	denotes	.
T10653	13736-13829	sentence	denotes	However, the deficit of motor learning in ADAM11-deficient mice was not clear in this study.
T10654	13737-13744	RB	denotes	However
T10656	13744-13746	,	denotes	,
T10657	13746-13749	DT	denotes	the
T10658	13750-13757	NN	denotes	deficit
T10659	13758-13760	IN	denotes	of
T10660	13761-13766	NN	denotes	motor
T10661	13767-13775	NN	denotes	learning
T10662	13776-13778	IN	denotes	in
T10663	13779-13785	NN	denotes	ADAM11
T10665	13785-13786	HYPH	denotes	-
T10664	13786-13795	JJ	denotes	deficient
T10666	13796-13800	NNS	denotes	mice
T10655	13801-13804	VBD	denotes	was
T10667	13805-13808	RB	denotes	not
T10668	13809-13814	JJ	denotes	clear
T10669	13815-13817	IN	denotes	in
T10670	13818-13822	DT	denotes	this
T10671	13823-13828	NN	denotes	study
T10672	13828-13829	.	denotes	.
T10673	13829-13910	sentence	denotes	Because they could not ride on the rotating rod, they might not learn this task.
T10674	13830-13837	IN	denotes	Because
T10676	13838-13842	PRP	denotes	they
T10677	13843-13848	MD	denotes	could
T10678	13849-13852	RB	denotes	not
T10675	13853-13857	VB	denotes	ride
T10680	13858-13860	IN	denotes	on
T10681	13861-13864	DT	denotes	the
T10683	13865-13873	VBG	denotes	rotating
T10682	13874-13877	NN	denotes	rod
T10684	13877-13879	,	denotes	,
T10685	13879-13883	PRP	denotes	they
T10686	13884-13889	MD	denotes	might
T10687	13890-13893	RB	denotes	not
T10679	13894-13899	VB	denotes	learn
T10688	13900-13904	DT	denotes	this
T10689	13905-13909	NN	denotes	task
T10690	13909-13910	.	denotes	.
T10691	13910-14089	sentence	denotes	To examine motor learning ability in ADAM11-deficient mice in detail, we will need to use other cerebellar-dependent learning tasks, such as a classical eyelid conditioning test.
T10692	13911-13913	TO	denotes	To
T10693	13914-13921	VB	denotes	examine
T10695	13922-13927	NN	denotes	motor
T10696	13928-13936	NN	denotes	learning
T10697	13937-13944	NN	denotes	ability
T10698	13945-13947	IN	denotes	in
T10699	13948-13954	NN	denotes	ADAM11
T10701	13954-13955	HYPH	denotes	-
T10700	13955-13964	JJ	denotes	deficient
T10702	13965-13969	NNS	denotes	mice
T10703	13970-13972	IN	denotes	in
T10704	13973-13979	NN	denotes	detail
T10705	13979-13981	,	denotes	,
T10706	13981-13983	PRP	denotes	we
T10707	13984-13988	MD	denotes	will
T10694	13989-13993	VB	denotes	need
T10708	13994-13996	TO	denotes	to
T10709	13997-14000	VB	denotes	use
T10710	14001-14006	JJ	denotes	other
T10712	14007-14017	JJ	denotes	cerebellar
T10714	14017-14018	HYPH	denotes	-
T10713	14018-14027	JJ	denotes	dependent
T10715	14028-14036	NN	denotes	learning
T10711	14037-14042	NNS	denotes	tasks
T10716	14042-14044	,	denotes	,
T10717	14044-14048	JJ	denotes	such
T10718	14049-14051	IN	denotes	as
T10719	14052-14053	DT	denotes	a
T10721	14054-14063	JJ	denotes	classical
T10722	14064-14070	NN	denotes	eyelid
T10723	14071-14083	VBG	denotes	conditioning
T10720	14084-14088	NN	denotes	test
T10724	14088-14089	.	denotes	.
T10725	14089-14185	sentence	denotes	There was no impairment in the grip strength and wire suspension test in ADAM11-deficient mice.
T10726	14090-14095	EX	denotes	There
T10727	14096-14099	VBD	denotes	was
T10728	14100-14102	DT	denotes	no
T10729	14103-14113	NN	denotes	impairment
T10730	14114-14116	IN	denotes	in
T10731	14117-14120	DT	denotes	the
T10733	14121-14125	NN	denotes	grip
T10734	14126-14134	NN	denotes	strength
T10735	14135-14138	CC	denotes	and
T10736	14139-14143	NN	denotes	wire
T10737	14144-14154	NN	denotes	suspension
T10732	14155-14159	NN	denotes	test
T10738	14160-14162	IN	denotes	in
T10739	14163-14169	NN	denotes	ADAM11
T10741	14169-14170	HYPH	denotes	-
T10740	14170-14179	JJ	denotes	deficient
T10742	14180-14184	NNS	denotes	mice
T10743	14184-14185	.	denotes	.
T10744	14185-14422	sentence	denotes	Spontaneous motor activity and walking patterns of ADAM11-deficient mice were also found to be normal, suggesting that the dysfunction found in the rotating rod test was not derived from muscle weakness or other peripheral disturbances.
T10745	14186-14197	JJ	denotes	Spontaneous
T10747	14198-14203	NN	denotes	motor
T10746	14204-14212	NN	denotes	activity
T10749	14213-14216	CC	denotes	and
T10750	14217-14224	VBG	denotes	walking
T10751	14225-14233	NNS	denotes	patterns
T10752	14234-14236	IN	denotes	of
T10753	14237-14243	NN	denotes	ADAM11
T10755	14243-14244	HYPH	denotes	-
T10754	14244-14253	JJ	denotes	deficient
T10756	14254-14258	NNS	denotes	mice
T10757	14259-14263	VBD	denotes	were
T10758	14264-14268	RB	denotes	also
T10748	14269-14274	VBN	denotes	found
T10759	14275-14277	TO	denotes	to
T10760	14278-14280	VB	denotes	be
T10761	14281-14287	JJ	denotes	normal
T10762	14287-14289	,	denotes	,
T10763	14289-14299	VBG	denotes	suggesting
T10764	14300-14304	IN	denotes	that
T10766	14305-14308	DT	denotes	the
T10767	14309-14320	NN	denotes	dysfunction
T10768	14321-14326	VBN	denotes	found
T10769	14327-14329	IN	denotes	in
T10770	14330-14333	DT	denotes	the
T10772	14334-14342	VBG	denotes	rotating
T10773	14343-14346	NN	denotes	rod
T10771	14347-14351	NN	denotes	test
T10774	14352-14355	VBD	denotes	was
T10775	14356-14359	RB	denotes	not
T10765	14360-14367	VBN	denotes	derived
T10776	14368-14372	IN	denotes	from
T10777	14373-14379	NN	denotes	muscle
T10778	14380-14388	NN	denotes	weakness
T10779	14389-14391	CC	denotes	or
T10780	14392-14397	JJ	denotes	other
T10782	14398-14408	JJ	denotes	peripheral
T10781	14409-14421	NNS	denotes	disturbances
T10783	14421-14422	.	denotes	.
T10784	14422-14633	sentence	denotes	These results suggest that limited brain sites, mainly the hippocampus and cerebellum, might contribute to the dominant phenotype, spatial learning impairment and motor discoordination in ADAM11-deficient mice.
T10785	14423-14428	DT	denotes	These
T10786	14429-14436	NNS	denotes	results
T10787	14437-14444	VBP	denotes	suggest
T10788	14445-14449	IN	denotes	that
T10790	14450-14457	JJ	denotes	limited
T10792	14458-14463	NN	denotes	brain
T10791	14464-14469	NNS	denotes	sites
T10793	14469-14471	,	denotes	,
T10794	14471-14477	RB	denotes	mainly
T10796	14478-14481	DT	denotes	the
T10795	14482-14493	NN	denotes	hippocampus
T10797	14494-14497	CC	denotes	and
T10798	14498-14508	NN	denotes	cerebellum
T10799	14508-14510	,	denotes	,
T10800	14510-14515	MD	denotes	might
T10789	14516-14526	VB	denotes	contribute
T10801	14527-14529	IN	denotes	to
T10802	14530-14533	DT	denotes	the
T10804	14534-14542	JJ	denotes	dominant
T10803	14543-14552	NN	denotes	phenotype
T10805	14552-14554	,	denotes	,
T10806	14554-14561	JJ	denotes	spatial
T10807	14562-14570	NN	denotes	learning
T10808	14571-14581	NN	denotes	impairment
T10809	14582-14585	CC	denotes	and
T10810	14586-14591	NN	denotes	motor
T10811	14592-14607	NN	denotes	discoordination
T10812	14608-14610	IN	denotes	in
T10813	14611-14617	NN	denotes	ADAM11
T10815	14617-14618	HYPH	denotes	-
T10814	14618-14627	JJ	denotes	deficient
T10816	14628-14632	NNS	denotes	mice
T10817	14632-14633	.	denotes	.
T10818	14633-14845	sentence	denotes	In situ hybridisation analysis has detected Adam11 gene expression in the pyramidal cells of CA1–CA3 fields and granule cells of the dentate gyrus in the hippocampus and in granular cells in the cerebellum [25].
T10819	14634-14636	FW	denotes	In
T10820	14637-14641	FW	denotes	situ
T10821	14642-14655	NN	denotes	hybridisation
T10822	14656-14664	NN	denotes	analysis
T10824	14665-14668	VBZ	denotes	has
T10823	14669-14677	VBN	denotes	detected
T10825	14678-14684	NN	denotes	Adam11
T10826	14685-14689	NN	denotes	gene
T10827	14690-14700	NN	denotes	expression
T10828	14701-14703	IN	denotes	in
T10829	14704-14707	DT	denotes	the
T10831	14708-14717	JJ	denotes	pyramidal
T10830	14718-14723	NNS	denotes	cells
T10832	14724-14726	IN	denotes	of
T10833	14727-14730	NN	denotes	CA1
T10835	14730-14731	SYM	denotes	–
T10836	14731-14734	NN	denotes	CA3
T10834	14735-14741	NNS	denotes	fields
T10837	14742-14745	CC	denotes	and
T10838	14746-14753	NN	denotes	granule
T10839	14754-14759	NNS	denotes	cells
T10840	14760-14762	IN	denotes	of
T10841	14763-14766	DT	denotes	the
T10843	14767-14774	NN	denotes	dentate
T10842	14775-14780	NN	denotes	gyrus
T10844	14781-14783	IN	denotes	in
T10845	14784-14787	DT	denotes	the
T10846	14788-14799	NN	denotes	hippocampus
T10847	14800-14803	CC	denotes	and
T10848	14804-14806	IN	denotes	in
T10849	14807-14815	JJ	denotes	granular
T10850	14816-14821	NNS	denotes	cells
T10851	14822-14824	IN	denotes	in
T10852	14825-14828	DT	denotes	the
T10853	14829-14839	NN	denotes	cerebellum
T10854	14840-14841	-LRB-	denotes	[
T10855	14841-14843	CD	denotes	25
T10856	14843-14844	-RRB-	denotes	]
T10857	14844-14845	.	denotes	.
T10858	14845-15151	sentence	denotes	It is unlikely that morphological changes during development led to impairment of spatial learning and motor coordination, and morphological alterations in the cytoarchitecture of the hippocampus and cerebellum were not observed in ADAM11-deficient mice after histological investigation using HE staining.
T10859	14846-14848	PRP	denotes	It
T10860	14849-14851	VBZ	denotes	is
T10862	14852-14860	JJ	denotes	unlikely
T10863	14861-14865	IN	denotes	that
T10865	14866-14879	JJ	denotes	morphological
T10866	14880-14887	NNS	denotes	changes
T10867	14888-14894	IN	denotes	during
T10868	14895-14906	NN	denotes	development
T10864	14907-14910	VBD	denotes	led
T10869	14911-14913	IN	denotes	to
T10870	14914-14924	NN	denotes	impairment
T10871	14925-14927	IN	denotes	of
T10872	14928-14935	JJ	denotes	spatial
T10873	14936-14944	NN	denotes	learning
T10874	14945-14948	CC	denotes	and
T10875	14949-14954	NN	denotes	motor
T10876	14955-14967	NN	denotes	coordination
T10877	14967-14969	,	denotes	,
T10878	14969-14972	CC	denotes	and
T10879	14973-14986	JJ	denotes	morphological
T10880	14987-14998	NNS	denotes	alterations
T10881	14999-15001	IN	denotes	in
T10882	15002-15005	DT	denotes	the
T10883	15006-15022	NN	denotes	cytoarchitecture
T10884	15023-15025	IN	denotes	of
T10885	15026-15029	DT	denotes	the
T10886	15030-15041	NN	denotes	hippocampus
T10887	15042-15045	CC	denotes	and
T10888	15046-15056	NN	denotes	cerebellum
T10889	15057-15061	VBD	denotes	were
T10890	15062-15065	RB	denotes	not
T10861	15066-15074	VBN	denotes	observed
T10891	15075-15077	IN	denotes	in
T10892	15078-15084	NN	denotes	ADAM11
T10894	15084-15085	HYPH	denotes	-
T10893	15085-15094	JJ	denotes	deficient
T10895	15095-15099	NNS	denotes	mice
T10896	15100-15105	IN	denotes	after
T10897	15106-15118	JJ	denotes	histological
T10898	15119-15132	NN	denotes	investigation
T10899	15133-15138	VBG	denotes	using
T10900	15139-15141	NN	denotes	HE
T10901	15142-15150	NN	denotes	staining
T10902	15150-15151	.	denotes	.
T10903	15151-15318	sentence	denotes	However, because it is thought that ADAM11 plays a role in neuron-neuron or neuron-glial cell interactions, a more precise morphological investigation will be needed.
T10904	15152-15159	RB	denotes	However
T10906	15159-15161	,	denotes	,
T10907	15161-15168	IN	denotes	because
T10909	15169-15171	PRP	denotes	it
T10910	15172-15174	VBZ	denotes	is
T10908	15175-15182	VBN	denotes	thought
T10911	15183-15187	IN	denotes	that
T10913	15188-15194	NN	denotes	ADAM11
T10912	15195-15200	VBZ	denotes	plays
T10914	15201-15202	DT	denotes	a
T10915	15203-15207	NN	denotes	role
T10916	15208-15210	IN	denotes	in
T10917	15211-15217	NN	denotes	neuron
T10919	15217-15218	SYM	denotes	-
T10918	15218-15224	NN	denotes	neuron
T10921	15225-15227	CC	denotes	or
T10922	15228-15234	NN	denotes	neuron
T10924	15234-15235	SYM	denotes	-
T10925	15235-15240	JJ	denotes	glial
T10923	15241-15245	NN	denotes	cell
T10920	15246-15258	NNS	denotes	interactions
T10926	15258-15260	,	denotes	,
T10927	15260-15261	DT	denotes	a
T10929	15262-15266	RBR	denotes	more
T10930	15267-15274	JJ	denotes	precise
T10931	15275-15288	JJ	denotes	morphological
T10928	15289-15302	NN	denotes	investigation
T10932	15303-15307	MD	denotes	will
T10933	15308-15310	VB	denotes	be
T10905	15311-15317	VBN	denotes	needed
T10934	15317-15318	.	denotes	.
T10935	15318-15594	sentence	denotes	It has been reported that adhesion molecules, such as neural cell adhesion molecule (NCAM), are not only implicated in cell interactions during nervous system development, but are also recognised as important mediators of synaptic plasticity in the adult nervous system [35].
T10936	15319-15321	PRP	denotes	It
T10938	15322-15325	VBZ	denotes	has
T10939	15326-15330	VBN	denotes	been
T10937	15331-15339	VBN	denotes	reported
T10940	15340-15344	IN	denotes	that
T10942	15345-15353	NN	denotes	adhesion
T10943	15354-15363	NNS	denotes	molecules
T10944	15363-15365	,	denotes	,
T10945	15365-15369	JJ	denotes	such
T10946	15370-15372	IN	denotes	as
T10947	15373-15379	JJ	denotes	neural
T10948	15380-15384	NN	denotes	cell
T10950	15385-15393	NN	denotes	adhesion
T10949	15394-15402	NN	denotes	molecule
T10951	15403-15404	-LRB-	denotes	(
T10952	15404-15408	NN	denotes	NCAM
T10953	15408-15409	-RRB-	denotes	)
T10954	15409-15411	,	denotes	,
T10955	15411-15414	VBP	denotes	are
T10956	15415-15418	RB	denotes	not
T10957	15419-15423	RB	denotes	only
T10941	15424-15434	VBN	denotes	implicated
T10958	15435-15437	IN	denotes	in
T10959	15438-15442	NN	denotes	cell
T10960	15443-15455	NNS	denotes	interactions
T10961	15456-15462	IN	denotes	during
T10962	15463-15470	JJ	denotes	nervous
T10963	15471-15477	NN	denotes	system
T10964	15478-15489	NN	denotes	development
T10965	15489-15491	,	denotes	,
T10966	15491-15494	CC	denotes	but
T10967	15495-15498	VBP	denotes	are
T10969	15499-15503	RB	denotes	also
T10968	15504-15514	VBN	denotes	recognised
T10970	15515-15517	IN	denotes	as
T10971	15518-15527	JJ	denotes	important
T10972	15528-15537	NNS	denotes	mediators
T10973	15538-15540	IN	denotes	of
T10974	15541-15549	JJ	denotes	synaptic
T10975	15550-15560	NN	denotes	plasticity
T10976	15561-15563	IN	denotes	in
T10977	15564-15567	DT	denotes	the
T10979	15568-15573	JJ	denotes	adult
T10980	15574-15581	JJ	denotes	nervous
T10978	15582-15588	NN	denotes	system
T10981	15589-15590	-LRB-	denotes	[
T10982	15590-15592	CD	denotes	35
T10983	15592-15593	-RRB-	denotes	]
T10984	15593-15594	.	denotes	.
T10985	15594-15867	sentence	denotes	Changes in neuron excitability in the hippocampus, such as decreases in the post-burst after hyperpolarization (AHP), have been thought to affect long-term potentiation (LTP) [36], an experimental model of the synaptic changes thought to underlie learning and memory [37].
T10986	15595-15602	NNS	denotes	Changes
T10988	15603-15605	IN	denotes	in
T10989	15606-15612	NN	denotes	neuron
T10990	15613-15625	NN	denotes	excitability
T10991	15626-15628	IN	denotes	in
T10992	15629-15632	DT	denotes	the
T10993	15633-15644	NN	denotes	hippocampus
T10994	15644-15646	,	denotes	,
T10995	15646-15650	JJ	denotes	such
T10996	15651-15653	IN	denotes	as
T10997	15654-15663	NNS	denotes	decreases
T10998	15664-15666	IN	denotes	in
T10999	15667-15670	DT	denotes	the
T11000	15671-15681	JJ	denotes	post-burst
T11001	15682-15687	IN	denotes	after
T11002	15688-15705	NN	denotes	hyperpolarization
T11003	15706-15707	-LRB-	denotes	(
T11004	15707-15710	NN	denotes	AHP
T11005	15710-15711	-RRB-	denotes	)
T11006	15711-15713	,	denotes	,
T11007	15713-15717	VBP	denotes	have
T11008	15718-15722	VBN	denotes	been
T10987	15723-15730	VBN	denotes	thought
T11009	15731-15733	TO	denotes	to
T11010	15734-15740	VB	denotes	affect
T11011	15741-15745	JJ	denotes	long
T11013	15745-15746	HYPH	denotes	-
T11012	15746-15750	NN	denotes	term
T11014	15751-15763	NN	denotes	potentiation
T11015	15764-15765	-LRB-	denotes	(
T11016	15765-15768	NN	denotes	LTP
T11017	15768-15769	-RRB-	denotes	)
T11018	15770-15771	-LRB-	denotes	[
T11019	15771-15773	CD	denotes	36
T11020	15773-15774	-RRB-	denotes	]
T11021	15774-15776	,	denotes	,
T11022	15776-15778	DT	denotes	an
T11024	15779-15791	JJ	denotes	experimental
T11023	15792-15797	NN	denotes	model
T11025	15798-15800	IN	denotes	of
T11026	15801-15804	DT	denotes	the
T11028	15805-15813	JJ	denotes	synaptic
T11027	15814-15821	NNS	denotes	changes
T11029	15822-15829	VBN	denotes	thought
T11030	15830-15832	TO	denotes	to
T11031	15833-15841	VB	denotes	underlie
T11032	15842-15850	NN	denotes	learning
T11033	15851-15854	CC	denotes	and
T11034	15855-15861	NN	denotes	memory
T11035	15862-15863	-LRB-	denotes	[
T11036	15863-15865	CD	denotes	37
T11037	15865-15866	-RRB-	denotes	]
T11038	15866-15867	.	denotes	.
T11039	15867-16106	sentence	denotes	It has also been reported that mice lacking NMDA receptor for both NR2A and NR2C subunits showed motor dysfunction and complete loss of both spontaneous and evoked excitatory postsynaptic currents (EPSCs) in cerebellar granule cells [38].
T11040	15868-15870	PRP	denotes	It
T11042	15871-15874	VBZ	denotes	has
T11043	15875-15879	RB	denotes	also
T11044	15880-15884	VBN	denotes	been
T11041	15885-15893	VBN	denotes	reported
T11045	15894-15898	IN	denotes	that
T11047	15899-15903	NNS	denotes	mice
T11048	15904-15911	VBG	denotes	lacking
T11049	15912-15916	NN	denotes	NMDA
T11050	15917-15925	NN	denotes	receptor
T11051	15926-15929	IN	denotes	for
T11052	15930-15934	CC	denotes	both
T11054	15935-15939	NN	denotes	NR2A
T11055	15940-15943	CC	denotes	and
T11056	15944-15948	NN	denotes	NR2C
T11053	15949-15957	NNS	denotes	subunits
T11046	15958-15964	VBD	denotes	showed
T11057	15965-15970	NN	denotes	motor
T11058	15971-15982	NN	denotes	dysfunction
T11059	15983-15986	CC	denotes	and
T11060	15987-15995	JJ	denotes	complete
T11061	15996-16000	NN	denotes	loss
T11062	16001-16003	IN	denotes	of
T11063	16004-16008	CC	denotes	both
T11064	16009-16020	JJ	denotes	spontaneous
T11066	16021-16024	CC	denotes	and
T11067	16025-16031	VBN	denotes	evoked
T11068	16032-16042	JJ	denotes	excitatory
T11069	16043-16055	JJ	denotes	postsynaptic
T11065	16056-16064	NNS	denotes	currents
T11070	16065-16066	-LRB-	denotes	(
T11071	16066-16071	NNS	denotes	EPSCs
T11072	16071-16072	-RRB-	denotes	)
T11073	16073-16075	IN	denotes	in
T11074	16076-16086	JJ	denotes	cerebellar
T11076	16087-16094	NN	denotes	granule
T11075	16095-16100	NNS	denotes	cells
T11077	16101-16102	-LRB-	denotes	[
T11078	16102-16104	CD	denotes	38
T11079	16104-16105	-RRB-	denotes	]
T11080	16105-16106	.	denotes	.
T11081	16106-16278	sentence	denotes	Therefore, electrophyological studies to enable analysis of synaptic transmission and plasticity in the hippocampus and cerebellum of ADAM11-deficient mice will be needed.
T11082	16107-16116	RB	denotes	Therefore
T11084	16116-16118	,	denotes	,
T11085	16118-16136	JJ	denotes	electrophyological
T11086	16137-16144	NNS	denotes	studies
T11087	16145-16147	TO	denotes	to
T11088	16148-16154	VB	denotes	enable
T11089	16155-16163	NN	denotes	analysis
T11090	16164-16166	IN	denotes	of
T11091	16167-16175	JJ	denotes	synaptic
T11092	16176-16188	NN	denotes	transmission
T11093	16189-16192	CC	denotes	and
T11094	16193-16203	NN	denotes	plasticity
T11095	16204-16206	IN	denotes	in
T11096	16207-16210	DT	denotes	the
T11097	16211-16222	NN	denotes	hippocampus
T11098	16223-16226	CC	denotes	and
T11099	16227-16237	NN	denotes	cerebellum
T11100	16238-16240	IN	denotes	of
T11101	16241-16247	NN	denotes	ADAM11
T11103	16247-16248	HYPH	denotes	-
T11102	16248-16257	JJ	denotes	deficient
T11104	16258-16262	NNS	denotes	mice
T11105	16263-16267	MD	denotes	will
T11106	16268-16270	VB	denotes	be
T11083	16271-16277	VBN	denotes	needed
T11107	16277-16278	.	denotes	.
T11108	16278-16444	sentence	denotes	These studies might clarify whether ADAM11 plays an important signalling or structural role at the synaptic level and whether it participates in synaptic regulation.
T11109	16279-16284	DT	denotes	These
T11110	16285-16292	NNS	denotes	studies
T11112	16293-16298	MD	denotes	might
T11111	16299-16306	VB	denotes	clarify
T11113	16307-16314	IN	denotes	whether
T11115	16315-16321	NN	denotes	ADAM11
T11114	16322-16327	VBZ	denotes	plays
T11116	16328-16330	DT	denotes	an
T11118	16331-16340	JJ	denotes	important
T11119	16341-16351	NN	denotes	signalling
T11120	16352-16354	CC	denotes	or
T11121	16355-16365	JJ	denotes	structural
T11117	16366-16370	NN	denotes	role
T11122	16371-16373	IN	denotes	at
T11123	16374-16377	DT	denotes	the
T11125	16378-16386	JJ	denotes	synaptic
T11124	16387-16392	NN	denotes	level
T11126	16393-16396	CC	denotes	and
T11127	16397-16404	IN	denotes	whether
T11129	16405-16407	PRP	denotes	it
T11128	16408-16420	VBZ	denotes	participates
T11130	16421-16423	IN	denotes	in
T11131	16424-16432	JJ	denotes	synaptic
T11132	16433-16443	NN	denotes	regulation
T11133	16443-16444	.	denotes	.
T11134	16444-16594	sentence	denotes	ADAM11-deficient mice remained alive for more than one year without ataxia or tremor, but showed a deficit in spatial learning and motor dysfunction.
T11135	16445-16451	NN	denotes	ADAM11
T11137	16451-16452	HYPH	denotes	-
T11136	16452-16461	JJ	denotes	deficient
T11138	16462-16466	NNS	denotes	mice
T11139	16467-16475	VBD	denotes	remained
T11140	16476-16481	JJ	denotes	alive
T11141	16482-16485	IN	denotes	for
T11142	16486-16490	JJR	denotes	more
T11144	16491-16495	IN	denotes	than
T11143	16496-16499	CD	denotes	one
T11145	16500-16504	NN	denotes	year
T11146	16505-16512	IN	denotes	without
T11147	16513-16519	NN	denotes	ataxia
T11148	16520-16522	CC	denotes	or
T11149	16523-16529	NN	denotes	tremor
T11150	16529-16531	,	denotes	,
T11151	16531-16534	CC	denotes	but
T11152	16535-16541	VBD	denotes	showed
T11153	16542-16543	DT	denotes	a
T11154	16544-16551	NN	denotes	deficit
T11155	16552-16554	IN	denotes	in
T11156	16555-16562	JJ	denotes	spatial
T11157	16563-16571	NN	denotes	learning
T11158	16572-16575	CC	denotes	and
T11159	16576-16581	NN	denotes	motor
T11160	16582-16593	NN	denotes	dysfunction
T11161	16593-16594	.	denotes	.
T11162	16594-16753	sentence	denotes	On the other hand, mice lacking the Adam22 gene showed severe ataxia, exhibited marked hypomyelination of the peripheral nerves, and died before weaning [22].
T11163	16595-16597	IN	denotes	On
T11165	16598-16601	DT	denotes	the
T11167	16602-16607	JJ	denotes	other
T11166	16608-16612	NN	denotes	hand
T11168	16612-16614	,	denotes	,
T11169	16614-16618	NNS	denotes	mice
T11170	16619-16626	VBG	denotes	lacking
T11171	16627-16630	DT	denotes	the
T11173	16631-16637	NN	denotes	Adam22
T11172	16638-16642	NN	denotes	gene
T11164	16643-16649	VBD	denotes	showed
T11174	16650-16656	JJ	denotes	severe
T11175	16657-16663	NN	denotes	ataxia
T11176	16663-16665	,	denotes	,
T11177	16665-16674	VBD	denotes	exhibited
T11178	16675-16681	JJ	denotes	marked
T11179	16682-16697	NN	denotes	hypomyelination
T11180	16698-16700	IN	denotes	of
T11181	16701-16704	DT	denotes	the
T11183	16705-16715	JJ	denotes	peripheral
T11182	16716-16722	NNS	denotes	nerves
T11184	16722-16724	,	denotes	,
T11185	16724-16727	CC	denotes	and
T11186	16728-16732	VBD	denotes	died
T11187	16733-16739	IN	denotes	before
T11188	16740-16747	NN	denotes	weaning
T11189	16748-16749	-LRB-	denotes	[
T11190	16749-16751	CD	denotes	22
T11191	16751-16752	-RRB-	denotes	]
T11192	16752-16753	.	denotes	.
T11193	16753-16844	sentence	denotes	Mice lacking the Adam23 gene showed severe ataxia and tremor and died before weaning [23].
T11194	16754-16758	NNS	denotes	Mice
T11196	16759-16766	VBG	denotes	lacking
T11197	16767-16770	DT	denotes	the
T11199	16771-16777	NN	denotes	Adam23
T11198	16778-16782	NN	denotes	gene
T11195	16783-16789	VBD	denotes	showed
T11200	16790-16796	JJ	denotes	severe
T11201	16797-16803	NN	denotes	ataxia
T11202	16804-16807	CC	denotes	and
T11203	16808-16814	NN	denotes	tremor
T11204	16815-16818	CC	denotes	and
T11205	16819-16823	VBD	denotes	died
T11206	16824-16830	IN	denotes	before
T11207	16831-16838	NN	denotes	weaning
T11208	16839-16840	-LRB-	denotes	[
T11209	16840-16842	CD	denotes	23
T11210	16842-16843	-RRB-	denotes	]
T11211	16843-16844	.	denotes	.
T11212	16844-16955	sentence	denotes	These findings suggest that ADAM11, ADAM22 and ADAM23 have separate and important roles in the nervous system.
T11213	16845-16850	DT	denotes	These
T11214	16851-16859	NNS	denotes	findings
T11215	16860-16867	VBP	denotes	suggest
T11216	16868-16872	IN	denotes	that
T11218	16873-16879	NN	denotes	ADAM11
T11219	16879-16881	,	denotes	,
T11220	16881-16887	NN	denotes	ADAM22
T11221	16888-16891	CC	denotes	and
T11222	16892-16898	NN	denotes	ADAM23
T11217	16899-16903	VBP	denotes	have
T11223	16904-16912	JJ	denotes	separate
T11225	16913-16916	CC	denotes	and
T11226	16917-16926	JJ	denotes	important
T11224	16927-16932	NNS	denotes	roles
T11227	16933-16935	IN	denotes	in
T11228	16936-16939	DT	denotes	the
T11230	16940-16947	JJ	denotes	nervous
T11229	16948-16954	NN	denotes	system
T11231	16954-16955	.	denotes	.
T11232	16955-17123	sentence	denotes	A genome database search revealed orthologs of ADAM11, ADAM22 and ADAM23 genes to exist in vertebrates such as mammals, fish, and amphibians, but not in invertebrates.
T11233	16956-16957	DT	denotes	A
T11235	16958-16964	NN	denotes	genome
T11236	16965-16973	NN	denotes	database
T11234	16974-16980	NN	denotes	search
T11237	16981-16989	VBD	denotes	revealed
T11238	16990-16999	NNS	denotes	orthologs
T11240	17000-17002	IN	denotes	of
T11241	17003-17009	NN	denotes	ADAM11
T11243	17009-17011	,	denotes	,
T11244	17011-17017	NN	denotes	ADAM22
T11245	17018-17021	CC	denotes	and
T11246	17022-17028	NN	denotes	ADAM23
T11242	17029-17034	NNS	denotes	genes
T11247	17035-17037	TO	denotes	to
T11239	17038-17043	VB	denotes	exist
T11248	17044-17046	IN	denotes	in
T11249	17047-17058	NNS	denotes	vertebrates
T11250	17059-17063	JJ	denotes	such
T11251	17064-17066	IN	denotes	as
T11252	17067-17074	NNS	denotes	mammals
T11253	17074-17076	,	denotes	,
T11254	17076-17080	NNS	denotes	fish
T11255	17080-17082	,	denotes	,
T11256	17082-17085	CC	denotes	and
T11257	17086-17096	NNS	denotes	amphibians
T11258	17096-17098	,	denotes	,
T11259	17098-17101	CC	denotes	but
T11260	17102-17105	RB	denotes	not
T11261	17106-17108	IN	denotes	in
T11262	17109-17122	NNS	denotes	invertebrates
T11263	17122-17123	.	denotes	.
T11264	17123-17297	sentence	denotes	Although the precise molecular functions of these ADAMs are still unclear, further investigations will provide clues to understanding the nervous system of higher organisms.
T11265	17124-17132	IN	denotes	Although
T11267	17133-17136	DT	denotes	the
T11269	17137-17144	JJ	denotes	precise
T11270	17145-17154	JJ	denotes	molecular
T11268	17155-17164	NNS	denotes	functions
T11271	17165-17167	IN	denotes	of
T11272	17168-17173	DT	denotes	these
T11273	17174-17179	NNS	denotes	ADAMs
T11266	17180-17183	VBP	denotes	are
T11275	17184-17189	RB	denotes	still
T11276	17190-17197	JJ	denotes	unclear
T11277	17197-17199	,	denotes	,
T11278	17199-17206	JJ	denotes	further
T11279	17207-17221	NNS	denotes	investigations
T11280	17222-17226	MD	denotes	will
T11274	17227-17234	VB	denotes	provide
T11281	17235-17240	NNS	denotes	clues
T11282	17241-17243	IN	denotes	to
T11283	17244-17257	VBG	denotes	understanding
T11284	17258-17261	DT	denotes	the
T11286	17262-17269	JJ	denotes	nervous
T11285	17270-17276	NN	denotes	system
T11287	17277-17279	IN	denotes	of
T11288	17280-17286	JJR	denotes	higher
T11289	17287-17296	NNS	denotes	organisms
T11290	17296-17297	.	denotes	.
T11498	17310-17316	NN	denotes	ADAM11
T11500	17316-17317	HYPH	denotes	-
T11499	17317-17326	JJ	denotes	deficient
T11501	17327-17331	NNS	denotes	mice
T11502	17332-17340	VBD	denotes	survived
T11503	17341-17345	JJR	denotes	more
T11505	17346-17350	IN	denotes	than
T11504	17351-17354	CD	denotes	one
T11506	17355-17359	NN	denotes	year
T11507	17360-17367	IN	denotes	without
T11508	17368-17374	NN	denotes	ataxia
T11509	17375-17377	CC	denotes	or
T11510	17378-17384	NN	denotes	tremor
T11511	17384-17386	,	denotes	,
T11512	17386-17392	VBD	denotes	showed
T11513	17393-17395	DT	denotes	no
T11514	17396-17409	NNS	denotes	abnormalities
T11515	17410-17412	IN	denotes	in
T11516	17413-17417	NN	denotes	body
T11517	17418-17424	NN	denotes	weight
T11518	17425-17429	NN	denotes	gain
T11519	17429-17431	,	denotes	,
T11520	17431-17442	JJ	denotes	spontaneous
T11522	17443-17448	NN	denotes	motor
T11521	17449-17457	NN	denotes	activity
T11523	17457-17459	,	denotes	,
T11524	17459-17465	NN	denotes	muscle
T11525	17466-17474	NN	denotes	strength
T11526	17474-17476	,	denotes	,
T11527	17476-17478	CC	denotes	or
T11528	17479-17486	NN	denotes	walking
T11529	17487-17495	NNS	denotes	patterns
T11530	17495-17497	,	denotes	,
T11531	17497-17500	CC	denotes	and
T11532	17501-17510	VBD	denotes	exhibited
T11533	17511-17513	DT	denotes	no
T11535	17514-17522	JJ	denotes	apparent
T11536	17523-17533	JJ	denotes	anatomical
T11538	17533-17534	HYPH	denotes	-
T11537	17534-17546	JJ	denotes	histological
T11534	17547-17554	NNS	denotes	changes
T11539	17554-17555	.	denotes	.
T11540	17555-17739	sentence	denotes	However, hippocampus-dependent spatial learning and cerebellum-dependent motor coordination in ADAM11-deficient mice were impaired when tested using water maze and rotating rod tasks.
T11541	17556-17563	RB	denotes	However
T11543	17563-17565	,	denotes	,
T11544	17565-17576	NN	denotes	hippocampus
T11546	17576-17577	HYPH	denotes	-
T11545	17577-17586	JJ	denotes	dependent
T11548	17587-17594	JJ	denotes	spatial
T11547	17595-17603	NN	denotes	learning
T11549	17604-17607	CC	denotes	and
T11550	17608-17618	NN	denotes	cerebellum
T11552	17618-17619	HYPH	denotes	-
T11551	17619-17628	JJ	denotes	dependent
T11554	17629-17634	NN	denotes	motor
T11553	17635-17647	NN	denotes	coordination
T11555	17648-17650	IN	denotes	in
T11556	17651-17657	NN	denotes	ADAM11
T11558	17657-17658	HYPH	denotes	-
T11557	17658-17667	JJ	denotes	deficient
T11559	17668-17672	NNS	denotes	mice
T11560	17673-17677	VBD	denotes	were
T11542	17678-17686	VBN	denotes	impaired
T11561	17687-17691	WRB	denotes	when
T11562	17692-17698	VBN	denotes	tested
T11563	17699-17704	VBG	denotes	using
T11564	17705-17710	NN	denotes	water
T11565	17711-17715	NN	denotes	maze
T11567	17716-17719	CC	denotes	and
T11568	17720-17728	VBG	denotes	rotating
T11569	17729-17732	NN	denotes	rod
T11566	17733-17738	NNS	denotes	tasks
T11570	17738-17739	.	denotes	.
T11571	17739-17908	sentence	denotes	Our genetically modified mouse strain has the potential to be a useful and sensitive tools for detailed investigation of ADAM proteins' functions in the nervous system.
T11572	17740-17743	PRP$	denotes	Our
T11574	17744-17755	RB	denotes	genetically
T11575	17756-17764	VBN	denotes	modified
T11576	17765-17770	NN	denotes	mouse
T11573	17771-17777	NN	denotes	strain
T11577	17778-17781	VBZ	denotes	has
T11578	17782-17785	DT	denotes	the
T11579	17786-17795	NN	denotes	potential
T11580	17796-17798	TO	denotes	to
T11581	17799-17801	VB	denotes	be
T11582	17802-17803	DT	denotes	a
T11584	17804-17810	JJ	denotes	useful
T11585	17811-17814	CC	denotes	and
T11586	17815-17824	JJ	denotes	sensitive
T11583	17825-17830	NNS	denotes	tools
T11587	17831-17834	IN	denotes	for
T11588	17835-17843	JJ	denotes	detailed
T11589	17844-17857	NN	denotes	investigation
T11590	17858-17860	IN	denotes	of
T11591	17861-17865	NN	denotes	ADAM
T11592	17866-17874	NN	denotes	proteins
T11594	17874-17875	POS	denotes	'
T11593	17876-17885	NNS	denotes	functions
T11595	17886-17888	IN	denotes	in
T11596	17889-17892	DT	denotes	the
T11598	17893-17900	JJ	denotes	nervous
T11597	17901-17907	NN	denotes	system
T11599	17907-17908	.	denotes	.
T11864	17919-17931	NN	denotes	Construction
T11865	17932-17934	IN	denotes	of
T11866	17935-17937	DT	denotes	an
T11868	17938-17944	NN	denotes	Adam11
T11869	17945-17949	NN	denotes	gene
T11870	17949-17950	HYPH	denotes	-
T11871	17950-17959	VBG	denotes	targeting
T11867	17960-17966	NN	denotes	vector
T11872	17966-18166	sentence	denotes	The 13.7-kb BamHI DNA fragment covering exons 2 – 20 of the Adam11 gene was amplified from C57BL/6 genomic DNA by the PCR using Expand Hi-Fidelity polymerase mix (Roche Diagnostics KK, Tokyo, Japan).
T11873	17967-17970	DT	denotes	The
T11875	17971-17975	CD	denotes	13.7
T11877	17975-17976	HYPH	denotes	-
T11876	17976-17978	NN	denotes	kb
T11878	17979-17984	NN	denotes	BamHI
T11879	17985-17988	NN	denotes	DNA
T11874	17989-17997	NN	denotes	fragment
T11881	17998-18006	VBG	denotes	covering
T11882	18007-18012	NNS	denotes	exons
T11883	18013-18014	CD	denotes	2
T11884	18015-18016	SYM	denotes	–
T11885	18017-18019	CD	denotes	20
T11886	18020-18022	IN	denotes	of
T11887	18023-18026	DT	denotes	the
T11889	18027-18033	NN	denotes	Adam11
T11888	18034-18038	NN	denotes	gene
T11890	18039-18042	VBD	denotes	was
T11880	18043-18052	VBN	denotes	amplified
T11891	18053-18057	IN	denotes	from
T11892	18058-18063	NN	denotes	C57BL
T11894	18063-18064	HYPH	denotes	/
T11895	18064-18065	CD	denotes	6
T11896	18066-18073	JJ	denotes	genomic
T11893	18074-18077	NN	denotes	DNA
T11897	18078-18080	IN	denotes	by
T11898	18081-18084	DT	denotes	the
T11899	18085-18088	NN	denotes	PCR
T11900	18089-18094	VBG	denotes	using
T11901	18095-18101	NN	denotes	Expand
T11903	18102-18104	NNP	denotes	Hi
T11905	18104-18105	HYPH	denotes	-
T11904	18105-18113	NNP	denotes	Fidelity
T11906	18114-18124	NN	denotes	polymerase
T11902	18125-18128	NN	denotes	mix
T11907	18129-18130	-LRB-	denotes	(
T11909	18130-18135	NNP	denotes	Roche
T11910	18136-18147	NNP	denotes	Diagnostics
T11908	18148-18150	NNP	denotes	KK
T11911	18150-18152	,	denotes	,
T11912	18152-18157	NNP	denotes	Tokyo
T11913	18157-18159	,	denotes	,
T11914	18159-18164	NNP	denotes	Japan
T11915	18164-18165	-RRB-	denotes	)
T11916	18165-18166	.	denotes	.
T11917	18166-18282	sentence	denotes	To generate a mutation in the mouse Adam11 gene, we inserted a PGKneo cassette into exons 5 – 7 of the Adam11 gene.
T11918	18167-18169	TO	denotes	To
T11919	18170-18178	VB	denotes	generate
T11921	18179-18180	DT	denotes	a
T11922	18181-18189	NN	denotes	mutation
T11923	18190-18192	IN	denotes	in
T11924	18193-18196	DT	denotes	the
T11926	18197-18202	NN	denotes	mouse
T11927	18203-18209	NN	denotes	Adam11
T11925	18210-18214	NN	denotes	gene
T11928	18214-18216	,	denotes	,
T11929	18216-18218	PRP	denotes	we
T11920	18219-18227	VBD	denotes	inserted
T11930	18228-18229	DT	denotes	a
T11932	18230-18236	NN	denotes	PGKneo
T11931	18237-18245	NN	denotes	cassette
T11933	18246-18250	IN	denotes	into
T11934	18251-18256	NNS	denotes	exons
T11935	18257-18258	CD	denotes	5
T11936	18259-18260	SYM	denotes	–
T11937	18261-18262	CD	denotes	7
T11938	18263-18265	IN	denotes	of
T11939	18266-18269	DT	denotes	the
T11941	18270-18276	NN	denotes	Adam11
T11940	18277-18281	NN	denotes	gene
T11942	18281-18282	.	denotes	.
T11943	18282-18513	sentence	denotes	The final targeting construct consisted of a 10.1-kb genomic DNA fragment that was interrupted by the insertion of the PGKneo cassette and contained a MC1/TK cassette as a negative selection marker against random integration [39].
T11944	18283-18286	DT	denotes	The
T11946	18287-18292	JJ	denotes	final
T11947	18293-18302	NN	denotes	targeting
T11945	18303-18312	NN	denotes	construct
T11948	18313-18322	VBD	denotes	consisted
T11949	18323-18325	IN	denotes	of
T11950	18326-18327	DT	denotes	a
T11952	18328-18332	CD	denotes	10.1
T11954	18332-18333	HYPH	denotes	-
T11953	18333-18335	NN	denotes	kb
T11955	18336-18343	JJ	denotes	genomic
T11956	18344-18347	NN	denotes	DNA
T11951	18348-18356	NN	denotes	fragment
T11957	18357-18361	WDT	denotes	that
T11959	18362-18365	VBD	denotes	was
T11958	18366-18377	VBN	denotes	interrupted
T11960	18378-18380	IN	denotes	by
T11961	18381-18384	DT	denotes	the
T11962	18385-18394	NN	denotes	insertion
T11963	18395-18397	IN	denotes	of
T11964	18398-18401	DT	denotes	the
T11966	18402-18408	NN	denotes	PGKneo
T11965	18409-18417	NN	denotes	cassette
T11967	18418-18421	CC	denotes	and
T11968	18422-18431	VBD	denotes	contained
T11969	18432-18433	DT	denotes	a
T11971	18434-18437	NN	denotes	MC1
T11973	18437-18438	HYPH	denotes	/
T11972	18438-18440	NN	denotes	TK
T11970	18441-18449	NN	denotes	cassette
T11974	18450-18452	IN	denotes	as
T11975	18453-18454	DT	denotes	a
T11977	18455-18463	JJ	denotes	negative
T11978	18464-18473	NN	denotes	selection
T11976	18474-18480	NN	denotes	marker
T11979	18481-18488	IN	denotes	against
T11980	18489-18495	JJ	denotes	random
T11981	18496-18507	NN	denotes	integration
T11982	18508-18509	-LRB-	denotes	[
T11983	18509-18511	CD	denotes	39
T11984	18511-18512	-RRB-	denotes	]
T11985	18512-18513	.	denotes	.
T12309	18515-18525	NN	denotes	Generation
T12310	18526-18528	IN	denotes	of
T12311	18529-18535	NN	denotes	Adam11
T12312	18536-18545	JJ	denotes	deficient
T12313	18546-18550	NNS	denotes	mice
T12314	18550-18642	sentence	denotes	The linearised targeting vector was electroporated into TT2 embryonic stem (ES) cells [40].
T12315	18551-18554	DT	denotes	The
T12317	18555-18565	VBN	denotes	linearised
T12318	18566-18575	NN	denotes	targeting
T12316	18576-18582	NN	denotes	vector
T12320	18583-18586	VBD	denotes	was
T12319	18587-18601	VBN	denotes	electroporated
T12321	18602-18606	IN	denotes	into
T12322	18607-18610	NN	denotes	TT2
T12324	18611-18620	JJ	denotes	embryonic
T12325	18621-18625	NN	denotes	stem
T12326	18626-18627	-LRB-	denotes	(
T12327	18627-18629	NN	denotes	ES
T12328	18629-18630	-RRB-	denotes	)
T12323	18631-18636	NNS	denotes	cells
T12329	18637-18638	-LRB-	denotes	[
T12330	18638-18640	CD	denotes	40
T12331	18640-18641	-RRB-	denotes	]
T12332	18641-18642	.	denotes	.
T12333	18642-18856	sentence	denotes	Homologous recombinants were selected by PCR using the following primers, AGN1: 5'-TCGTGCTTTACGGTATCGCCGCTCCCGATT-3' in the PGKneo cassette, and SGN033: 5'-GGACCCGGAAGACATTTGCACGGT-3' outside the targeting vector.
T12334	18643-18653	JJ	denotes	Homologous
T12335	18654-18666	NNS	denotes	recombinants
T12337	18667-18671	VBD	denotes	were
T12336	18672-18680	VBN	denotes	selected
T12338	18681-18683	IN	denotes	by
T12339	18684-18687	NN	denotes	PCR
T12340	18688-18693	VBG	denotes	using
T12341	18694-18697	DT	denotes	the
T12343	18698-18707	VBG	denotes	following
T12342	18708-18715	NNS	denotes	primers
T12344	18715-18717	,	denotes	,
T12345	18717-18721	NN	denotes	AGN1
T12346	18721-18723	:	denotes	:
T12347	18723-18724	CD	denotes	5
T12348	18724-18725	SYM	denotes	'
T12349	18725-18726	HYPH	denotes	-
T12350	18726-18756	NN	denotes	TCGTGCTTTACGGTATCGCCGCTCCCGATT
T12351	18756-18757	HYPH	denotes	-
T12352	18757-18758	CD	denotes	3
T12353	18758-18759	SYM	denotes	'
T12354	18760-18762	IN	denotes	in
T12355	18763-18766	DT	denotes	the
T12357	18767-18773	NN	denotes	PGKneo
T12356	18774-18782	NN	denotes	cassette
T12358	18782-18784	,	denotes	,
T12359	18784-18787	CC	denotes	and
T12360	18788-18794	NN	denotes	SGN033
T12361	18794-18796	:	denotes	:
T12362	18796-18797	CD	denotes	5
T12363	18797-18798	SYM	denotes	'
T12364	18798-18799	HYPH	denotes	-
T12365	18799-18823	NN	denotes	GGACCCGGAAGACATTTGCACGGT
T12366	18823-18824	HYPH	denotes	-
T12367	18824-18825	CD	denotes	3
T12368	18825-18826	SYM	denotes	'
T12369	18827-18834	IN	denotes	outside
T12370	18835-18838	DT	denotes	the
T12372	18839-18848	NN	denotes	targeting
T12371	18849-18855	NN	denotes	vector
T12373	18855-18856	.	denotes	.
T12374	18856-18988	sentence	denotes	Homologous recombined DNA was efficiently amplified by 35 cycles of the following amplification steps (94°C-30 sec and 68°C-5 min).
T12375	18857-18867	JJ	denotes	Homologous
T12377	18868-18878	VBN	denotes	recombined
T12376	18879-18882	NN	denotes	DNA
T12379	18883-18886	VBD	denotes	was
T12380	18887-18898	RB	denotes	efficiently
T12378	18899-18908	VBN	denotes	amplified
T12381	18909-18911	IN	denotes	by
T12382	18912-18914	CD	denotes	35
T12383	18915-18921	NNS	denotes	cycles
T12384	18922-18924	IN	denotes	of
T12385	18925-18928	DT	denotes	the
T12387	18929-18938	VBG	denotes	following
T12388	18939-18952	NN	denotes	amplification
T12386	18953-18958	NNS	denotes	steps
T12389	18959-18960	-LRB-	denotes	(
T12390	18960-18962	CD	denotes	94
T12391	18962-18964	NN	denotes	°C
T12392	18964-18965	SYM	denotes	-
T12393	18965-18967	CD	denotes	30
T12394	18968-18971	NN	denotes	sec
T12395	18972-18975	CC	denotes	and
T12396	18976-18978	CD	denotes	68
T12397	18978-18980	NN	denotes	°C
T12398	18980-18981	SYM	denotes	-
T12399	18981-18982	CD	denotes	5
T12400	18983-18986	NN	denotes	min
T12401	18986-18987	-RRB-	denotes	)
T12402	18987-18988	.	denotes	.
T12403	18988-19087	sentence	denotes	Correctly targeted ES clones were injected into fertilised ICR mouse eggs at the eight-cell stage.
T12404	18989-18998	RB	denotes	Correctly
T12405	18999-19007	VBN	denotes	targeted
T12407	19008-19010	NN	denotes	ES
T12406	19011-19017	NNS	denotes	clones
T12409	19018-19022	VBD	denotes	were
T12408	19023-19031	VBN	denotes	injected
T12410	19032-19036	IN	denotes	into
T12411	19037-19047	VBN	denotes	fertilised
T12413	19048-19051	NN	denotes	ICR
T12414	19052-19057	NN	denotes	mouse
T12412	19058-19062	NNS	denotes	eggs
T12415	19063-19065	IN	denotes	at
T12416	19066-19069	DT	denotes	the
T12418	19070-19075	CD	denotes	eight
T12420	19075-19076	HYPH	denotes	-
T12419	19076-19080	NN	denotes	cell
T12417	19081-19086	NN	denotes	stage
T12421	19086-19087	.	denotes	.
T12422	19087-19292	sentence	denotes	The resulting male chimeras were mated with C57BL/6NCrj females (Charles River Japan, Tokyo, Japan), and resulting heterozygous (+/-) male and female mice were interbred to generate homozygous (-/-) mice.
T12423	19088-19091	DT	denotes	The
T12425	19092-19101	VBG	denotes	resulting
T12426	19102-19106	JJ	denotes	male
T12424	19107-19115	NNS	denotes	chimeras
T12428	19116-19120	VBD	denotes	were
T12427	19121-19126	VBN	denotes	mated
T12429	19127-19131	IN	denotes	with
T12430	19132-19137	NN	denotes	C57BL
T12432	19137-19138	HYPH	denotes	/
T12431	19138-19143	NN	denotes	6NCrj
T12433	19144-19151	NNS	denotes	females
T12434	19152-19153	-LRB-	denotes	(
T12436	19153-19160	NNP	denotes	Charles
T12437	19161-19166	NNP	denotes	River
T12435	19167-19172	NNP	denotes	Japan
T12438	19172-19174	,	denotes	,
T12439	19174-19179	NNP	denotes	Tokyo
T12440	19179-19181	,	denotes	,
T12441	19181-19186	NNP	denotes	Japan
T12442	19186-19187	-RRB-	denotes	)
T12443	19187-19189	,	denotes	,
T12444	19189-19192	CC	denotes	and
T12445	19193-19202	VBG	denotes	resulting
T12447	19203-19215	JJ	denotes	heterozygous
T12448	19216-19217	-LRB-	denotes	(
T12449	19217-19218	SYM	denotes	+
T12451	19218-19219	HYPH	denotes	/
T12450	19219-19220	SYM	denotes	-
T12452	19220-19221	-RRB-	denotes	)
T12453	19222-19226	JJ	denotes	male
T12454	19227-19230	CC	denotes	and
T12455	19231-19237	JJ	denotes	female
T12446	19238-19242	NNS	denotes	mice
T12457	19243-19247	VBD	denotes	were
T12456	19248-19257	VBN	denotes	interbred
T12458	19258-19260	TO	denotes	to
T12459	19261-19269	VB	denotes	generate
T12460	19270-19280	JJ	denotes	homozygous
T12462	19281-19282	-LRB-	denotes	(
T12463	19282-19283	SYM	denotes	-
T12465	19283-19284	HYPH	denotes	/
T12464	19284-19285	SYM	denotes	-
T12466	19285-19286	-RRB-	denotes	)
T12461	19287-19291	NNS	denotes	mice
T12467	19291-19292	.	denotes	.
T12588	19294-19302	NNP	denotes	Southern
T12589	19303-19307	NN	denotes	blot
T12590	19308-19316	NN	denotes	analysis
T12591	19316-19413	sentence	denotes	Mouse genomic DNA used for Southern blot analysis was extracted from the liver of each genotype.
T12592	19317-19322	NN	denotes	Mouse
T12594	19323-19330	JJ	denotes	genomic
T12593	19331-19334	NN	denotes	DNA
T12596	19335-19339	VBN	denotes	used
T12597	19340-19343	IN	denotes	for
T12598	19344-19352	NNP	denotes	Southern
T12599	19353-19357	NN	denotes	blot
T12600	19358-19366	NN	denotes	analysis
T12601	19367-19370	VBD	denotes	was
T12595	19371-19380	VBN	denotes	extracted
T12602	19381-19385	IN	denotes	from
T12603	19386-19389	DT	denotes	the
T12604	19390-19395	NN	denotes	liver
T12605	19396-19398	IN	denotes	of
T12606	19399-19403	DT	denotes	each
T12607	19404-19412	NN	denotes	genotype
T12608	19412-19413	.	denotes	.
T12609	19413-19558	sentence	denotes	BamHI-digested genomic DNA was probed with the [32P]-labelled BE2K probe, which was a 2.0-kb BamHI – EcoRI genomic fragment located in intron 2.
T12610	19414-19419	NN	denotes	BamHI
T12612	19419-19420	HYPH	denotes	-
T12611	19420-19428	VBN	denotes	digested
T12614	19429-19436	JJ	denotes	genomic
T12613	19437-19440	NN	denotes	DNA
T12616	19441-19444	VBD	denotes	was
T12615	19445-19451	VBN	denotes	probed
T12617	19452-19456	IN	denotes	with
T12618	19457-19460	DT	denotes	the
T12620	19461-19462	-LRB-	denotes	[
T12621	19462-19465	NN	denotes	32P
T12623	19465-19466	-RRB-	denotes	]
T12624	19466-19467	HYPH	denotes	-
T12622	19467-19475	VBN	denotes	labelled
T12625	19476-19480	NN	denotes	BE2K
T12619	19481-19486	NN	denotes	probe
T12626	19486-19488	,	denotes	,
T12627	19488-19493	WDT	denotes	which
T12628	19494-19497	VBD	denotes	was
T12629	19498-19499	DT	denotes	a
T12631	19500-19503	CD	denotes	2.0
T12633	19503-19504	HYPH	denotes	-
T12632	19504-19506	NN	denotes	kb
T12634	19507-19512	NN	denotes	BamHI
T12636	19513-19514	HYPH	denotes	–
T12635	19515-19520	NN	denotes	EcoRI
T12637	19521-19528	JJ	denotes	genomic
T12630	19529-19537	NN	denotes	fragment
T12638	19538-19545	VBN	denotes	located
T12639	19546-19548	IN	denotes	in
T12640	19549-19555	NN	denotes	intron
T12641	19556-19557	CD	denotes	2
T12642	19557-19558	.	denotes	.
T13011	19560-19567	NNP	denotes	Western
T13012	19568-19572	NN	denotes	blot
T13013	19573-19581	NN	denotes	analysis
T13014	19581-19669	sentence	denotes	The absence of ADAM11 protein in the (-/-) mice was confirmed by Western blot analysis.
T13015	19582-19585	DT	denotes	The
T13016	19586-19593	NN	denotes	absence
T13018	19594-19596	IN	denotes	of
T13019	19597-19603	NN	denotes	ADAM11
T13020	19604-19611	NN	denotes	protein
T13021	19612-19614	IN	denotes	in
T13022	19615-19618	DT	denotes	the
T13024	19619-19620	-LRB-	denotes	(
T13025	19620-19621	SYM	denotes	-
T13027	19621-19622	HYPH	denotes	/
T13026	19622-19623	SYM	denotes	-
T13028	19623-19624	-RRB-	denotes	)
T13023	19625-19629	NNS	denotes	mice
T13029	19630-19633	VBD	denotes	was
T13017	19634-19643	VBN	denotes	confirmed
T13030	19644-19646	IN	denotes	by
T13031	19647-19654	NNP	denotes	Western
T13032	19655-19659	NN	denotes	blot
T13033	19660-19668	NN	denotes	analysis
T13034	19668-19669	.	denotes	.
T13035	19669-19889	sentence	denotes	To be brief, the cerebellum was isolated from a six month-old mouse of each genotype and homogenised in cell lysis buffer (50 mM Tris-HCl, pH 7.5, 100 mM NaCl, 1% NP-40, protease inhibitor cocktail [Roche Diagnostics]).
T13036	19670-19672	TO	denotes	To
T13037	19673-19675	VB	denotes	be
T13039	19676-19681	JJ	denotes	brief
T13040	19681-19683	,	denotes	,
T13041	19683-19686	DT	denotes	the
T13042	19687-19697	NN	denotes	cerebellum
T13043	19698-19701	VBD	denotes	was
T13038	19702-19710	VBN	denotes	isolated
T13044	19711-19715	IN	denotes	from
T13045	19716-19717	DT	denotes	a
T13047	19718-19721	CD	denotes	six
T13048	19722-19727	NN	denotes	month
T13050	19727-19728	HYPH	denotes	-
T13049	19728-19731	JJ	denotes	old
T13046	19732-19737	NN	denotes	mouse
T13051	19738-19740	IN	denotes	of
T13052	19741-19745	DT	denotes	each
T13053	19746-19754	NN	denotes	genotype
T13054	19755-19758	CC	denotes	and
T13055	19759-19770	VBN	denotes	homogenised
T13056	19771-19773	IN	denotes	in
T13057	19774-19778	NN	denotes	cell
T13058	19779-19784	NN	denotes	lysis
T13059	19785-19791	NN	denotes	buffer
T13060	19792-19793	-LRB-	denotes	(
T13062	19793-19795	CD	denotes	50
T13063	19796-19798	NN	denotes	mM
T13065	19799-19803	NN	denotes	Tris
T13066	19803-19804	HYPH	denotes	-
T13064	19804-19807	NN	denotes	HCl
T13067	19807-19809	,	denotes	,
T13068	19809-19811	NN	denotes	pH
T13069	19812-19815	CD	denotes	7.5
T13070	19815-19817	,	denotes	,
T13071	19817-19820	CD	denotes	100
T13072	19821-19823	NN	denotes	mM
T13073	19824-19828	NN	denotes	NaCl
T13074	19828-19830	,	denotes	,
T13075	19830-19831	CD	denotes	1
T13076	19831-19832	NN	denotes	%
T13077	19833-19835	NN	denotes	NP
T13078	19835-19836	HYPH	denotes	-
T13079	19836-19838	CD	denotes	40
T13080	19838-19840	,	denotes	,
T13081	19840-19848	NN	denotes	protease
T13082	19849-19858	NN	denotes	inhibitor
T13061	19859-19867	NN	denotes	cocktail
T13083	19868-19869	-LRB-	denotes	[
T13085	19869-19874	NNP	denotes	Roche
T13084	19875-19886	NNP	denotes	Diagnostics
T13086	19886-19887	-RRB-	denotes	]
T13087	19887-19888	-RRB-	denotes	)
T13088	19888-19889	.	denotes	.
T13089	19889-20086	sentence	denotes	After removal of cell debris by centrifugation, the glycosylated proteins in the supernatant were concentrated by the affinity chromatography using Con A Sepharose 4B (Amersham Biosciences Corp.).
T13090	19890-19895	IN	denotes	After
T13092	19896-19903	NN	denotes	removal
T13093	19904-19906	IN	denotes	of
T13094	19907-19911	NN	denotes	cell
T13095	19912-19918	NN	denotes	debris
T13096	19919-19921	IN	denotes	by
T13097	19922-19936	NN	denotes	centrifugation
T13098	19936-19938	,	denotes	,
T13099	19938-19941	DT	denotes	the
T13101	19942-19954	VBN	denotes	glycosylated
T13100	19955-19963	NN	denotes	proteins
T13102	19964-19966	IN	denotes	in
T13103	19967-19970	DT	denotes	the
T13104	19971-19982	NN	denotes	supernatant
T13105	19983-19987	VBD	denotes	were
T13091	19988-20000	VBN	denotes	concentrated
T13106	20001-20003	IN	denotes	by
T13107	20004-20007	DT	denotes	the
T13109	20008-20016	NN	denotes	affinity
T13108	20017-20031	NN	denotes	chromatography
T13110	20032-20037	VBG	denotes	using
T13111	20038-20041	NN	denotes	Con
T13113	20042-20043	NN	denotes	A
T13114	20044-20053	NN	denotes	Sepharose
T13112	20054-20056	NN	denotes	4B
T13115	20057-20058	-LRB-	denotes	(
T13117	20058-20066	NNP	denotes	Amersham
T13118	20067-20078	NNP	denotes	Biosciences
T13116	20079-20084	NNP	denotes	Corp.
T13119	20084-20085	-RRB-	denotes	)
T13120	20085-20086	.	denotes	.
T13121	20086-20165	sentence	denotes	Each sample was separated on 10% SDS-PAGE, and transferred to a PVDF membrane.
T13122	20087-20091	DT	denotes	Each
T13123	20092-20098	NN	denotes	sample
T13125	20099-20102	VBD	denotes	was
T13124	20103-20112	VBN	denotes	separated
T13126	20113-20115	IN	denotes	on
T13127	20116-20118	CD	denotes	10
T13128	20118-20119	NN	denotes	%
T13130	20120-20123	NN	denotes	SDS
T13131	20123-20124	HYPH	denotes	-
T13129	20124-20128	NN	denotes	PAGE
T13132	20128-20130	,	denotes	,
T13133	20130-20133	CC	denotes	and
T13134	20134-20145	VBN	denotes	transferred
T13135	20146-20148	IN	denotes	to
T13136	20149-20150	DT	denotes	a
T13138	20151-20155	NN	denotes	PVDF
T13137	20156-20164	NN	denotes	membrane
T13139	20164-20165	.	denotes	.
T13140	20165-20274	sentence	denotes	The blot was then incubated with monoclonal antibody against the ADAM11 (U. S. Patent 5,631,351) at 1 μg/ml.
T13141	20166-20169	DT	denotes	The
T13142	20170-20174	NN	denotes	blot
T13144	20175-20178	VBD	denotes	was
T13145	20179-20183	RB	denotes	then
T13143	20184-20193	VBN	denotes	incubated
T13146	20194-20198	IN	denotes	with
T13147	20199-20209	JJ	denotes	monoclonal
T13148	20210-20218	NN	denotes	antibody
T13149	20219-20226	IN	denotes	against
T13150	20227-20230	DT	denotes	the
T13151	20231-20237	NN	denotes	ADAM11
T13152	20238-20239	-LRB-	denotes	(
T13154	20239-20241	NNP	denotes	U.
T13155	20242-20244	NNP	denotes	S.
T13153	20245-20251	NN	denotes	Patent
T13156	20252-20261	CD	denotes	5,631,351
T13157	20261-20262	-RRB-	denotes	)
T13158	20263-20265	IN	denotes	at
T13159	20266-20267	CD	denotes	1
T13160	20268-20270	NN	denotes	μg
T13161	20270-20271	SYM	denotes	/
T13162	20271-20273	NN	denotes	ml
T13163	20273-20274	.	denotes	.
T13164	20274-20441	sentence	denotes	Bound antibodies were visualised with horseradish peroxidase-labelled second antibody and an ECL-plus chemiluminescence detection system (Amersham Biosciences Corp.).
T13165	20275-20280	JJ	denotes	Bound
T13166	20281-20291	NNS	denotes	antibodies
T13168	20292-20296	VBD	denotes	were
T13167	20297-20307	VBN	denotes	visualised
T13169	20308-20312	IN	denotes	with
T13170	20313-20324	NN	denotes	horseradish
T13171	20325-20335	NN	denotes	peroxidase
T13173	20335-20336	HYPH	denotes	-
T13172	20336-20344	VBN	denotes	labelled
T13175	20345-20351	JJ	denotes	second
T13174	20352-20360	NN	denotes	antibody
T13176	20361-20364	CC	denotes	and
T13177	20365-20367	DT	denotes	an
T13179	20368-20371	NN	denotes	ECL
T13181	20371-20372	HYPH	denotes	-
T13180	20372-20376	NN	denotes	plus
T13182	20377-20394	NN	denotes	chemiluminescence
T13183	20395-20404	NN	denotes	detection
T13178	20405-20411	NN	denotes	system
T13184	20412-20413	-LRB-	denotes	(
T13186	20413-20421	NNP	denotes	Amersham
T13187	20422-20433	NNP	denotes	Biosciences
T13185	20434-20439	NNP	denotes	Corp.
T13188	20439-20440	-RRB-	denotes	)
T13189	20440-20441	.	denotes	.
T13416	20443-20454	JJ	denotes	Behavioural
T13417	20455-20463	NN	denotes	analysis
T13418	20463-20734	sentence	denotes	All animal procedures conformed to the Japanese regulations on animal care and use, following the Guideline for Animal Experimentation of the Japanese Association for Laboratory of Animal Science, and were approved by the Animal Care and Use Committee of Eisai Co., Ltd.
T13419	20464-20467	DT	denotes	All
T13421	20468-20474	NN	denotes	animal
T13420	20475-20485	NNS	denotes	procedures
T13422	20486-20495	VBD	denotes	conformed
T13423	20496-20498	IN	denotes	to
T13424	20499-20502	DT	denotes	the
T13426	20503-20511	JJ	denotes	Japanese
T13425	20512-20523	NNS	denotes	regulations
T13427	20524-20526	IN	denotes	on
T13428	20527-20533	NN	denotes	animal
T13429	20534-20538	NN	denotes	care
T13430	20539-20542	CC	denotes	and
T13431	20543-20546	NN	denotes	use
T13432	20546-20548	,	denotes	,
T13433	20548-20557	VBG	denotes	following
T13434	20558-20561	DT	denotes	the
T13435	20562-20571	NNP	denotes	Guideline
T13436	20572-20575	IN	denotes	for
T13437	20576-20582	NNP	denotes	Animal
T13438	20583-20598	NNP	denotes	Experimentation
T13439	20599-20601	IN	denotes	of
T13440	20602-20605	DT	denotes	the
T13442	20606-20614	NNP	denotes	Japanese
T13441	20615-20626	NNP	denotes	Association
T13443	20627-20630	IN	denotes	for
T13444	20631-20641	NNP	denotes	Laboratory
T13445	20642-20644	IN	denotes	of
T13446	20645-20651	NNP	denotes	Animal
T13447	20652-20659	NNP	denotes	Science
T13448	20659-20661	,	denotes	,
T13449	20661-20664	CC	denotes	and
T13450	20665-20669	VBD	denotes	were
T13451	20670-20678	VBN	denotes	approved
T13452	20679-20681	IN	denotes	by
T13453	20682-20685	DT	denotes	the
T13455	20686-20692	NNP	denotes	Animal
T13456	20693-20697	NNP	denotes	Care
T13457	20698-20701	CC	denotes	and
T13458	20702-20705	NNP	denotes	Use
T13454	20706-20715	NNP	denotes	Committee
T13459	20716-20718	IN	denotes	of
T13460	20719-20724	NNP	denotes	Eisai
T13461	20725-20728	NNP	denotes	Co.
T13462	20728-20730	,	denotes	,
T13463	20730-20733	NNP	denotes	Ltd
T13464	20733-20734	.	denotes	.
T13465	20734-20901	sentence	denotes	For the present experiments, ADAM11-deficient male mice (backcrossed generations into C57BL/6NCrj, n = 14) were used in all behavioural analyses (22–24 weeks of age).
T13466	20735-20738	IN	denotes	For
T13468	20739-20742	DT	denotes	the
T13470	20743-20750	JJ	denotes	present
T13469	20751-20762	NNS	denotes	experiments
T13471	20762-20764	,	denotes	,
T13472	20764-20770	NN	denotes	ADAM11
T13474	20770-20771	HYPH	denotes	-
T13473	20771-20780	JJ	denotes	deficient
T13476	20781-20785	JJ	denotes	male
T13475	20786-20790	NNS	denotes	mice
T13477	20791-20792	-LRB-	denotes	(
T13479	20792-20803	VBN	denotes	backcrossed
T13478	20804-20815	NNS	denotes	generations
T13480	20816-20820	IN	denotes	into
T13481	20821-20826	NN	denotes	C57BL
T13483	20826-20827	HYPH	denotes	/
T13482	20827-20832	NN	denotes	6NCrj
T13484	20832-20834	,	denotes	,
T13485	20834-20835	NN	denotes	n
T13487	20836-20837	SYM	denotes	=
T13486	20838-20840	CD	denotes	14
T13488	20840-20841	-RRB-	denotes	)
T13489	20842-20846	VBD	denotes	were
T13467	20847-20851	VBN	denotes	used
T13490	20852-20854	IN	denotes	in
T13491	20855-20858	DT	denotes	all
T13493	20859-20870	JJ	denotes	behavioural
T13492	20871-20879	NNS	denotes	analyses
T13494	20880-20881	-LRB-	denotes	(
T13496	20881-20883	CD	denotes	22
T13498	20883-20884	SYM	denotes	–
T13497	20884-20886	CD	denotes	24
T13495	20887-20892	NNS	denotes	weeks
T13499	20893-20895	IN	denotes	of
T13500	20896-20899	NN	denotes	age
T13501	20899-20900	-RRB-	denotes	)
T13502	20900-20901	.	denotes	.
T13503	20901-21032	sentence	denotes	All of the behavioural studies were conducted between 10:00 and 16:00 by a well-trained experimenter blind to the mouse genotypes.
T13504	20902-20905	DT	denotes	All
T13506	20906-20908	IN	denotes	of
T13507	20909-20912	DT	denotes	the
T13509	20913-20924	JJ	denotes	behavioural
T13508	20925-20932	NNS	denotes	studies
T13510	20933-20937	VBD	denotes	were
T13505	20938-20947	VBN	denotes	conducted
T13511	20948-20955	IN	denotes	between
T13512	20956-20958	CD	denotes	10
T13514	20958-20959	:	denotes	:
T13513	20959-20961	CD	denotes	00
T13515	20962-20965	CC	denotes	and
T13516	20966-20968	CD	denotes	16
T13518	20968-20969	:	denotes	:
T13517	20969-20971	CD	denotes	00
T13519	20972-20974	IN	denotes	by
T13520	20975-20976	DT	denotes	a
T13522	20977-20981	RB	denotes	well
T13524	20981-20982	HYPH	denotes	-
T13523	20982-20989	VBN	denotes	trained
T13521	20990-21002	NN	denotes	experimenter
T13525	21003-21008	JJ	denotes	blind
T13526	21009-21011	IN	denotes	to
T13527	21012-21015	DT	denotes	the
T13529	21016-21021	NN	denotes	mouse
T13528	21022-21031	NNS	denotes	genotypes
T13530	21031-21032	.	denotes	.
T13661	21034-21045	JJ	denotes	Spontaneous
T13663	21046-21051	NN	denotes	motor
T13662	21052-21060	NN	denotes	activity
T13664	21060-21303	sentence	denotes	Locomotor activity in a novel environment was measured by introducing mice (+/+, +/- and -/-; n = 8, 8 and 8, respectively) for 90 min in a Plexiglas box (30 × 20 × 13 cm) using a VERSAMAX equipment and software (Accuscan, Columbus, OH, USA).
T13665	21061-21070	NN	denotes	Locomotor
T13666	21071-21079	NN	denotes	activity
T13668	21080-21082	IN	denotes	in
T13669	21083-21084	DT	denotes	a
T13671	21085-21090	JJ	denotes	novel
T13670	21091-21102	NN	denotes	environment
T13672	21103-21106	VBD	denotes	was
T13667	21107-21115	VBN	denotes	measured
T13673	21116-21118	IN	denotes	by
T13674	21119-21130	VBG	denotes	introducing
T13675	21131-21135	NNS	denotes	mice
T13676	21136-21137	-LRB-	denotes	(
T13678	21137-21138	SYM	denotes	+
T13679	21138-21139	HYPH	denotes	/
T13677	21139-21140	SYM	denotes	+
T13680	21140-21142	,	denotes	,
T13681	21142-21143	SYM	denotes	+
T13683	21143-21144	HYPH	denotes	/
T13682	21144-21145	SYM	denotes	-
T13684	21146-21149	CC	denotes	and
T13685	21150-21151	SYM	denotes	-
T13687	21151-21152	HYPH	denotes	/
T13686	21152-21153	SYM	denotes	-
T13688	21153-21154	:	denotes	;
T13689	21155-21156	NN	denotes	n
T13691	21157-21158	SYM	denotes	=
T13690	21159-21160	CD	denotes	8
T13692	21160-21162	,	denotes	,
T13693	21162-21163	CD	denotes	8
T13694	21164-21167	CC	denotes	and
T13695	21168-21169	CD	denotes	8
T13696	21169-21171	,	denotes	,
T13697	21171-21183	RB	denotes	respectively
T13698	21183-21184	-RRB-	denotes	)
T13699	21185-21188	IN	denotes	for
T13700	21189-21191	CD	denotes	90
T13701	21192-21195	NN	denotes	min
T13702	21196-21198	IN	denotes	in
T13703	21199-21200	DT	denotes	a
T13705	21201-21210	NN	denotes	Plexiglas
T13704	21211-21214	NN	denotes	box
T13706	21215-21216	-LRB-	denotes	(
T13708	21216-21218	CD	denotes	30
T13709	21219-21220	SYM	denotes	×
T13710	21221-21223	CD	denotes	20
T13711	21224-21225	SYM	denotes	×
T13712	21226-21228	CD	denotes	13
T13707	21229-21231	NN	denotes	cm
T13713	21231-21232	-RRB-	denotes	)
T13714	21233-21238	VBG	denotes	using
T13715	21239-21240	DT	denotes	a
T13717	21241-21249	NNP	denotes	VERSAMAX
T13716	21250-21259	NN	denotes	equipment
T13718	21260-21263	CC	denotes	and
T13719	21264-21272	NN	denotes	software
T13720	21273-21274	-LRB-	denotes	(
T13721	21274-21282	NNP	denotes	Accuscan
T13722	21282-21284	,	denotes	,
T13723	21284-21292	NNP	denotes	Columbus
T13724	21292-21294	,	denotes	,
T13725	21294-21296	NNP	denotes	OH
T13726	21296-21298	,	denotes	,
T13727	21298-21301	NNP	denotes	USA
T13728	21301-21302	-RRB-	denotes	)
T13729	21302-21303	.	denotes	.
T14364	21305-21310	NN	denotes	Water
T14365	21311-21315	NN	denotes	maze
T14366	21316-21320	NN	denotes	task
T14367	21320-21421	sentence	denotes	Spatial learning was assessed by three variants of the Morris water maze task [27] adapted for mice.
T14368	21321-21328	JJ	denotes	Spatial
T14369	21329-21337	NN	denotes	learning
T14371	21338-21341	VBD	denotes	was
T14370	21342-21350	VBN	denotes	assessed
T14372	21351-21353	IN	denotes	by
T14373	21354-21359	CD	denotes	three
T14374	21360-21368	NNS	denotes	variants
T14375	21369-21371	IN	denotes	of
T14376	21372-21375	DT	denotes	the
T14378	21376-21382	NNP	denotes	Morris
T14379	21383-21388	NN	denotes	water
T14380	21389-21393	NN	denotes	maze
T14377	21394-21398	NN	denotes	task
T14381	21399-21400	-LRB-	denotes	[
T14382	21400-21402	CD	denotes	27
T14383	21402-21403	-RRB-	denotes	]
T14384	21404-21411	VBN	denotes	adapted
T14385	21412-21415	IN	denotes	for
T14386	21416-21420	NNS	denotes	mice
T14387	21420-21421	.	denotes	.
T14388	21421-21581	sentence	denotes	Hidden platform task: The pool was divided into four quadrants with four starting locations, called north, east, south and west, at equal distances to the rim.
T14389	21422-21428	JJ	denotes	Hidden
T14391	21429-21437	NN	denotes	platform
T14390	21438-21442	NN	denotes	task
T14393	21442-21444	:	denotes	:
T14394	21444-21447	DT	denotes	The
T14395	21448-21452	NN	denotes	pool
T14396	21453-21456	VBD	denotes	was
T14392	21457-21464	VBN	denotes	divided
T14397	21465-21469	IN	denotes	into
T14398	21470-21474	CD	denotes	four
T14399	21475-21484	NNS	denotes	quadrants
T14400	21485-21489	IN	denotes	with
T14402	21490-21494	CD	denotes	four
T14404	21495-21503	NN	denotes	starting
T14403	21504-21513	NNS	denotes	locations
T14405	21513-21515	,	denotes	,
T14406	21515-21521	VBN	denotes	called
T14407	21522-21527	NN	denotes	north
T14408	21527-21529	,	denotes	,
T14409	21529-21533	NN	denotes	east
T14410	21533-21535	,	denotes	,
T14411	21535-21540	NN	denotes	south
T14412	21541-21544	CC	denotes	and
T14413	21545-21549	NN	denotes	west
T14414	21549-21551	,	denotes	,
T14401	21551-21553	IN	denotes	at
T14415	21554-21559	JJ	denotes	equal
T14416	21560-21569	NNS	denotes	distances
T14417	21570-21572	IN	denotes	to
T14418	21573-21576	DT	denotes	the
T14419	21577-21580	NN	denotes	rim
T14420	21580-21581	.	denotes	.
T14421	21581-21757	sentence	denotes	A circular, transparent acrylic platform (diameter 8 cm) was submerged 1 cm below the surface of the water in the centre of the southeast quadrant for each trial of this task.
T14422	21582-21583	DT	denotes	A
T14424	21584-21592	JJ	denotes	circular
T14425	21592-21594	,	denotes	,
T14426	21594-21605	JJ	denotes	transparent
T14427	21606-21613	JJ	denotes	acrylic
T14423	21614-21622	NN	denotes	platform
T14429	21623-21624	-LRB-	denotes	(
T14431	21624-21632	NN	denotes	diameter
T14432	21633-21634	CD	denotes	8
T14430	21635-21637	NN	denotes	cm
T14433	21637-21638	-RRB-	denotes	)
T14434	21639-21642	VBD	denotes	was
T14428	21643-21652	VBN	denotes	submerged
T14435	21653-21654	CD	denotes	1
T14436	21655-21657	NN	denotes	cm
T14437	21658-21663	IN	denotes	below
T14438	21664-21667	DT	denotes	the
T14439	21668-21675	NN	denotes	surface
T14440	21676-21678	IN	denotes	of
T14441	21679-21682	DT	denotes	the
T14442	21683-21688	NN	denotes	water
T14443	21689-21691	IN	denotes	in
T14444	21692-21695	DT	denotes	the
T14445	21696-21702	NN	denotes	centre
T14446	21703-21705	IN	denotes	of
T14447	21706-21709	DT	denotes	the
T14449	21710-21719	NN	denotes	southeast
T14448	21720-21728	NN	denotes	quadrant
T14450	21729-21732	IN	denotes	for
T14451	21733-21737	DT	denotes	each
T14452	21738-21743	NN	denotes	trial
T14453	21744-21746	IN	denotes	of
T14454	21747-21751	DT	denotes	this
T14455	21752-21756	NN	denotes	task
T14456	21756-21757	.	denotes	.
T14457	21757-21888	sentence	denotes	Each mouse was allowed to swim for 60 sec and the time required to reach the platform (escape latency) was recorded in each trial.
T14458	21758-21762	DT	denotes	Each
T14459	21763-21768	NN	denotes	mouse
T14461	21769-21772	VBD	denotes	was
T14460	21773-21780	VBN	denotes	allowed
T14462	21781-21783	TO	denotes	to
T14463	21784-21788	VB	denotes	swim
T14464	21789-21792	IN	denotes	for
T14465	21793-21795	CD	denotes	60
T14466	21796-21799	NN	denotes	sec
T14467	21800-21803	CC	denotes	and
T14468	21804-21807	DT	denotes	the
T14469	21808-21812	NN	denotes	time
T14471	21813-21821	VBN	denotes	required
T14472	21822-21824	TO	denotes	to
T14473	21825-21830	VB	denotes	reach
T14474	21831-21834	DT	denotes	the
T14475	21835-21843	NN	denotes	platform
T14476	21844-21845	-LRB-	denotes	(
T14477	21845-21851	NN	denotes	escape
T14478	21852-21859	NN	denotes	latency
T14479	21859-21860	-RRB-	denotes	)
T14480	21861-21864	VBD	denotes	was
T14470	21865-21873	VBN	denotes	recorded
T14481	21874-21876	IN	denotes	in
T14482	21877-21881	DT	denotes	each
T14483	21882-21887	NN	denotes	trial
T14484	21887-21888	.	denotes	.
T14485	21888-21983	sentence	denotes	In total this task consisted of four trials per day over 9 days (1 min inter-trial intervals).
T14486	21889-21891	IN	denotes	In
T14488	21892-21897	JJ	denotes	total
T14489	21898-21902	DT	denotes	this
T14490	21903-21907	NN	denotes	task
T14487	21908-21917	VBD	denotes	consisted
T14491	21918-21920	IN	denotes	of
T14492	21921-21925	CD	denotes	four
T14493	21926-21932	NNS	denotes	trials
T14494	21933-21936	IN	denotes	per
T14495	21937-21940	NN	denotes	day
T14496	21941-21945	IN	denotes	over
T14497	21946-21947	CD	denotes	9
T14498	21948-21952	NNS	denotes	days
T14499	21953-21954	-LRB-	denotes	(
T14501	21954-21955	CD	denotes	1
T14502	21956-21959	NN	denotes	min
T14503	21960-21971	JJ	denotes	inter-trial
T14500	21972-21981	NNS	denotes	intervals
T14504	21981-21982	-RRB-	denotes	)
T14505	21982-21983	.	denotes	.
T14506	21983-22077	sentence	denotes	Each trial was initiated by randomly placing an animal in one of the four starting locations.
T14507	21984-21988	DT	denotes	Each
T14508	21989-21994	NN	denotes	trial
T14510	21995-21998	VBD	denotes	was
T14509	21999-22008	VBN	denotes	initiated
T14511	22009-22011	IN	denotes	by
T14512	22012-22020	RB	denotes	randomly
T14513	22021-22028	VBG	denotes	placing
T14514	22029-22031	DT	denotes	an
T14515	22032-22038	NN	denotes	animal
T14516	22039-22041	IN	denotes	in
T14517	22042-22045	CD	denotes	one
T14518	22046-22048	IN	denotes	of
T14519	22049-22052	DT	denotes	the
T14521	22053-22057	CD	denotes	four
T14522	22058-22066	NN	denotes	starting
T14520	22067-22076	NNS	denotes	locations
T14523	22076-22077	.	denotes	.
T14524	22077-22178	sentence	denotes	Probe trial: A single probe trial was carried out after the hidden platform task had been completed.
T14525	22078-22083	NN	denotes	Probe
T14526	22084-22089	NN	denotes	trial
T14528	22089-22091	:	denotes	:
T14529	22091-22092	DT	denotes	A
T14531	22093-22099	JJ	denotes	single
T14532	22100-22105	NN	denotes	probe
T14530	22106-22111	NN	denotes	trial
T14533	22112-22115	VBD	denotes	was
T14527	22116-22123	VBN	denotes	carried
T14534	22124-22127	RP	denotes	out
T14535	22128-22133	IN	denotes	after
T14537	22134-22137	DT	denotes	the
T14539	22138-22144	JJ	denotes	hidden
T14540	22145-22153	NN	denotes	platform
T14538	22154-22158	NN	denotes	task
T14541	22159-22162	VBD	denotes	had
T14542	22163-22167	VBN	denotes	been
T14536	22168-22177	VBN	denotes	completed
T14543	22177-22178	.	denotes	.
T14544	22178-22358	sentence	denotes	In this trial, the platform was removed and the movement of each mouse was monitored using a computer-based video tracking system (BTA-2; Muromachi Kikai Co., Ltd., Tokyo, Japan).
T14545	22179-22181	IN	denotes	In
T14547	22182-22186	DT	denotes	this
T14548	22187-22192	NN	denotes	trial
T14549	22192-22194	,	denotes	,
T14550	22194-22197	DT	denotes	the
T14551	22198-22206	NN	denotes	platform
T14552	22207-22210	VBD	denotes	was
T14546	22211-22218	VBN	denotes	removed
T14553	22219-22222	CC	denotes	and
T14554	22223-22226	DT	denotes	the
T14555	22227-22235	NN	denotes	movement
T14557	22236-22238	IN	denotes	of
T14558	22239-22243	DT	denotes	each
T14559	22244-22249	NN	denotes	mouse
T14560	22250-22253	VBD	denotes	was
T14556	22254-22263	VBN	denotes	monitored
T14561	22264-22269	VBG	denotes	using
T14562	22270-22271	DT	denotes	a
T14564	22272-22280	NN	denotes	computer
T14566	22280-22281	HYPH	denotes	-
T14565	22281-22286	VBN	denotes	based
T14567	22287-22292	NN	denotes	video
T14568	22293-22301	NN	denotes	tracking
T14563	22302-22308	NN	denotes	system
T14569	22309-22310	-LRB-	denotes	(
T14571	22310-22313	NN	denotes	BTA
T14572	22313-22314	HYPH	denotes	-
T14573	22314-22315	CD	denotes	2
T14574	22315-22316	:	denotes	;
T14575	22317-22326	NNP	denotes	Muromachi
T14576	22327-22332	NNP	denotes	Kikai
T14570	22333-22336	NNP	denotes	Co.
T14577	22336-22338	,	denotes	,
T14578	22338-22342	NNP	denotes	Ltd.
T14579	22342-22344	,	denotes	,
T14580	22344-22349	NNP	denotes	Tokyo
T14581	22349-22351	,	denotes	,
T14582	22351-22356	NNP	denotes	Japan
T14583	22356-22357	-RRB-	denotes	)
T14584	22357-22358	.	denotes	.
T14585	22358-22452	sentence	denotes	Each mouse was placed into the northwest quadrant of the pool and allowed to swim for 60 sec.
T14586	22359-22363	DT	denotes	Each
T14587	22364-22369	NN	denotes	mouse
T14589	22370-22373	VBD	denotes	was
T14588	22374-22380	VBN	denotes	placed
T14590	22381-22385	IN	denotes	into
T14591	22386-22389	DT	denotes	the
T14593	22390-22399	NN	denotes	northwest
T14592	22400-22408	NN	denotes	quadrant
T14594	22409-22411	IN	denotes	of
T14595	22412-22415	DT	denotes	the
T14596	22416-22420	NN	denotes	pool
T14597	22421-22424	CC	denotes	and
T14598	22425-22432	VBN	denotes	allowed
T14599	22433-22435	TO	denotes	to
T14600	22436-22440	VB	denotes	swim
T14601	22441-22444	IN	denotes	for
T14602	22445-22447	CD	denotes	60
T14603	22448-22451	NN	denotes	sec
T14604	22451-22452	.	denotes	.
T14605	22452-22541	sentence	denotes	Swim path length and the time spent in the trained (southeast) quadrant were calculated.
T14606	22453-22457	NN	denotes	Swim
T14607	22458-22462	NN	denotes	path
T14608	22463-22469	NN	denotes	length
T14610	22470-22473	CC	denotes	and
T14611	22474-22477	DT	denotes	the
T14612	22478-22482	NN	denotes	time
T14613	22483-22488	VBN	denotes	spent
T14614	22489-22491	IN	denotes	in
T14615	22492-22495	DT	denotes	the
T14617	22496-22503	VBN	denotes	trained
T14618	22504-22505	-LRB-	denotes	(
T14619	22505-22514	NN	denotes	southeast
T14620	22514-22515	-RRB-	denotes	)
T14616	22516-22524	NN	denotes	quadrant
T14621	22525-22529	VBD	denotes	were
T14609	22530-22540	VBN	denotes	calculated
T14622	22540-22541	.	denotes	.
T14623	22541-22709	sentence	denotes	Visible platform task: In this task, the circular platform was made visible by attaching a black board to it and the mouse was required to locate the visible platform.
T14624	22542-22549	JJ	denotes	Visible
T14626	22550-22558	NN	denotes	platform
T14625	22559-22563	NN	denotes	task
T14628	22563-22565	:	denotes	:
T14629	22565-22567	IN	denotes	In
T14630	22568-22572	DT	denotes	this
T14631	22573-22577	NN	denotes	task
T14632	22577-22579	,	denotes	,
T14633	22579-22582	DT	denotes	the
T14635	22583-22591	JJ	denotes	circular
T14634	22592-22600	NN	denotes	platform
T14636	22601-22604	VBD	denotes	was
T14627	22605-22609	VBN	denotes	made
T14637	22610-22617	JJ	denotes	visible
T14638	22618-22620	IN	denotes	by
T14639	22621-22630	VBG	denotes	attaching
T14640	22631-22632	DT	denotes	a
T14642	22633-22638	JJ	denotes	black
T14641	22639-22644	NN	denotes	board
T14643	22645-22647	IN	denotes	to
T14644	22648-22650	PRP	denotes	it
T14645	22651-22654	CC	denotes	and
T14646	22655-22658	DT	denotes	the
T14647	22659-22664	NN	denotes	mouse
T14649	22665-22668	VBD	denotes	was
T14648	22669-22677	VBN	denotes	required
T14650	22678-22680	TO	denotes	to
T14651	22681-22687	VB	denotes	locate
T14652	22688-22691	DT	denotes	the
T14654	22692-22699	JJ	denotes	visible
T14653	22700-22708	NN	denotes	platform
T14655	22708-22709	.	denotes	.
T14656	22709-22855	sentence	denotes	The mouse was allowed to swim for 60 sec and this task consisted of four trials per day for three consecutive days (1 min inter-trial intervals).
T14657	22710-22713	DT	denotes	The
T14658	22714-22719	NN	denotes	mouse
T14660	22720-22723	VBD	denotes	was
T14659	22724-22731	VBN	denotes	allowed
T14661	22732-22734	TO	denotes	to
T14662	22735-22739	VB	denotes	swim
T14663	22740-22743	IN	denotes	for
T14664	22744-22746	CD	denotes	60
T14665	22747-22750	NN	denotes	sec
T14666	22751-22754	CC	denotes	and
T14667	22755-22759	DT	denotes	this
T14668	22760-22764	NN	denotes	task
T14669	22765-22774	VBD	denotes	consisted
T14670	22775-22777	IN	denotes	of
T14671	22778-22782	CD	denotes	four
T14672	22783-22789	NNS	denotes	trials
T14673	22790-22793	IN	denotes	per
T14674	22794-22797	NN	denotes	day
T14675	22798-22801	IN	denotes	for
T14676	22802-22807	CD	denotes	three
T14678	22808-22819	JJ	denotes	consecutive
T14677	22820-22824	NNS	denotes	days
T14679	22825-22826	-LRB-	denotes	(
T14681	22826-22827	CD	denotes	1
T14682	22828-22831	NN	denotes	min
T14683	22832-22843	JJ	denotes	inter-trial
T14680	22844-22853	NNS	denotes	intervals
T14684	22853-22854	-RRB-	denotes	)
T14685	22854-22855	.	denotes	.
T14686	22855-22949	sentence	denotes	Each trial was initiated by randomly placing an animal in one of the four starting locations.
T14687	22856-22860	DT	denotes	Each
T14688	22861-22866	NN	denotes	trial
T14690	22867-22870	VBD	denotes	was
T14689	22871-22880	VBN	denotes	initiated
T14691	22881-22883	IN	denotes	by
T14692	22884-22892	RB	denotes	randomly
T14693	22893-22900	VBG	denotes	placing
T14694	22901-22903	DT	denotes	an
T14695	22904-22910	NN	denotes	animal
T14696	22911-22913	IN	denotes	in
T14697	22914-22917	CD	denotes	one
T14698	22918-22920	IN	denotes	of
T14699	22921-22924	DT	denotes	the
T14701	22925-22929	CD	denotes	four
T14702	22930-22938	NN	denotes	starting
T14700	22939-22948	NNS	denotes	locations
T14703	22948-22949	.	denotes	.
T14924	22951-22959	VBG	denotes	Rotating
T14925	22960-22963	NN	denotes	rod
T14926	22964-22968	NN	denotes	test
T14927	22968-23200	sentence	denotes	Motor coordination was assessed with a rotating rod apparatus (KN-75, Natsume Seisakujo, Tokyo, Japan), which consisted of a plastic rod (3 cm diameter, 8 cm long) with a gritted surface flanked by two large discs (40 cm diameter).
T14928	22969-22974	NN	denotes	Motor
T14929	22975-22987	NN	denotes	coordination
T14931	22988-22991	VBD	denotes	was
T14930	22992-23000	VBN	denotes	assessed
T14932	23001-23005	IN	denotes	with
T14933	23006-23007	DT	denotes	a
T14935	23008-23016	VBG	denotes	rotating
T14936	23017-23020	NN	denotes	rod
T14934	23021-23030	NN	denotes	apparatus
T14937	23031-23032	-LRB-	denotes	(
T14939	23032-23034	NN	denotes	KN
T14940	23034-23035	HYPH	denotes	-
T14941	23035-23037	CD	denotes	75
T14942	23037-23039	,	denotes	,
T14943	23039-23046	NNP	denotes	Natsume
T14938	23047-23056	NNP	denotes	Seisakujo
T14944	23056-23058	,	denotes	,
T14945	23058-23063	NNP	denotes	Tokyo
T14946	23063-23065	,	denotes	,
T14947	23065-23070	NNP	denotes	Japan
T14948	23070-23071	-RRB-	denotes	)
T14949	23071-23073	,	denotes	,
T14950	23073-23078	WDT	denotes	which
T14951	23079-23088	VBD	denotes	consisted
T14952	23089-23091	IN	denotes	of
T14953	23092-23093	DT	denotes	a
T14955	23094-23101	NN	denotes	plastic
T14954	23102-23105	NN	denotes	rod
T14956	23106-23107	-LRB-	denotes	(
T14958	23107-23108	CD	denotes	3
T14959	23109-23111	NN	denotes	cm
T14957	23112-23120	NN	denotes	diameter
T14960	23120-23122	,	denotes	,
T14961	23122-23123	CD	denotes	8
T14962	23124-23126	NN	denotes	cm
T14963	23127-23131	JJ	denotes	long
T14964	23131-23132	-RRB-	denotes	)
T14965	23133-23137	IN	denotes	with
T14966	23138-23139	DT	denotes	a
T14968	23140-23147	JJ	denotes	gritted
T14967	23148-23155	NN	denotes	surface
T14969	23156-23163	VBN	denotes	flanked
T14970	23164-23166	IN	denotes	by
T14971	23167-23170	CD	denotes	two
T14973	23171-23176	JJ	denotes	large
T14972	23177-23182	NNS	denotes	discs
T14974	23183-23184	-LRB-	denotes	(
T14976	23184-23186	CD	denotes	40
T14977	23187-23189	NN	denotes	cm
T14975	23190-23198	NN	denotes	diameter
T14978	23198-23199	-RRB-	denotes	)
T14979	23199-23200	.	denotes	.
T14980	23200-23384	sentence	denotes	The mice were first placed on the stationary rod for 4 successive trials, followed by 4 trials at a rotation speed of 5 rpm, 8 trials at 10 rpm, and 20 trials at 15 rpm in that order.
T14981	23201-23204	DT	denotes	The
T14982	23205-23209	NNS	denotes	mice
T14984	23210-23214	VBD	denotes	were
T14985	23215-23220	RB	denotes	first
T14983	23221-23227	VBN	denotes	placed
T14986	23228-23230	IN	denotes	on
T14987	23231-23234	DT	denotes	the
T14989	23235-23245	JJ	denotes	stationary
T14988	23246-23249	NN	denotes	rod
T14990	23250-23253	IN	denotes	for
T14991	23254-23255	CD	denotes	4
T14993	23256-23266	JJ	denotes	successive
T14992	23267-23273	NNS	denotes	trials
T14994	23273-23275	,	denotes	,
T14995	23275-23283	VBN	denotes	followed
T14996	23284-23286	IN	denotes	by
T14997	23287-23288	CD	denotes	4
T14998	23289-23295	NNS	denotes	trials
T14999	23296-23298	IN	denotes	at
T15000	23299-23300	DT	denotes	a
T15002	23301-23309	NN	denotes	rotation
T15001	23310-23315	NN	denotes	speed
T15003	23316-23318	IN	denotes	of
T15004	23319-23320	CD	denotes	5
T15005	23321-23324	NN	denotes	rpm
T15006	23324-23326	,	denotes	,
T15007	23326-23327	CD	denotes	8
T15008	23328-23334	NNS	denotes	trials
T15009	23335-23337	IN	denotes	at
T15010	23338-23340	CD	denotes	10
T15011	23341-23344	NN	denotes	rpm
T15012	23344-23346	,	denotes	,
T15013	23346-23349	CC	denotes	and
T15014	23350-23352	CD	denotes	20
T15015	23353-23359	NNS	denotes	trials
T15016	23360-23362	IN	denotes	at
T15017	23363-23365	CD	denotes	15
T15018	23366-23369	NN	denotes	rpm
T15019	23370-23372	IN	denotes	in
T15020	23373-23377	DT	denotes	that
T15021	23378-23383	NN	denotes	order
T15022	23383-23384	.	denotes	.
T15023	23384-23441	sentence	denotes	Latency until a fall occurred was monitored for 120 sec.
T15024	23385-23392	NN	denotes	Latency
T15026	23393-23398	IN	denotes	until
T15028	23399-23400	DT	denotes	a
T15029	23401-23405	NN	denotes	fall
T15027	23406-23414	VBD	denotes	occurred
T15030	23415-23418	VBD	denotes	was
T15025	23419-23428	VBN	denotes	monitored
T15031	23429-23432	IN	denotes	for
T15032	23433-23436	CD	denotes	120
T15033	23437-23440	NN	denotes	sec
T15034	23440-23441	.	denotes	.
T15035	23441-23502	sentence	denotes	Intra-trial intervals for each animal were more than 20 min.
T15036	23442-23453	JJ	denotes	Intra-trial
T15037	23454-23463	NNS	denotes	intervals
T15039	23464-23467	IN	denotes	for
T15040	23468-23472	DT	denotes	each
T15041	23473-23479	NN	denotes	animal
T15038	23480-23484	VBD	denotes	were
T15042	23485-23489	JJR	denotes	more
T15044	23490-23494	IN	denotes	than
T15043	23495-23497	CD	denotes	20
T15045	23498-23501	NN	denotes	min
T15046	23501-23502	.	denotes	.
T15164	23504-23512	NN	denotes	Traction
T15165	23513-23517	NN	denotes	test
T15166	23517-23623	sentence	denotes	The grip strength of each mouse was measured with a traction apparatus (FU-1, Muromachi Kikai Co., Ltd.).
T15167	23518-23521	DT	denotes	The
T15169	23522-23526	NN	denotes	grip
T15168	23527-23535	NN	denotes	strength
T15171	23536-23538	IN	denotes	of
T15172	23539-23543	DT	denotes	each
T15173	23544-23549	NN	denotes	mouse
T15174	23550-23553	VBD	denotes	was
T15170	23554-23562	VBN	denotes	measured
T15175	23563-23567	IN	denotes	with
T15176	23568-23569	DT	denotes	a
T15178	23570-23578	NN	denotes	traction
T15177	23579-23588	NN	denotes	apparatus
T15179	23589-23590	-LRB-	denotes	(
T15181	23590-23592	NN	denotes	FU
T15182	23592-23593	HYPH	denotes	-
T15183	23593-23594	CD	denotes	1
T15184	23594-23596	,	denotes	,
T15185	23596-23605	NNP	denotes	Muromachi
T15186	23606-23611	NNP	denotes	Kikai
T15180	23612-23615	NNP	denotes	Co.
T15187	23615-23617	,	denotes	,
T15188	23617-23621	NNP	denotes	Ltd.
T15189	23621-23622	-RRB-	denotes	)
T15190	23622-23623	.	denotes	.
T15191	23623-23743	sentence	denotes	Each mouse was made to grasp the attached bar (2 mm diameter) with the forepaws and was slowly pulled back by the tail.
T15192	23624-23628	DT	denotes	Each
T15193	23629-23634	NN	denotes	mouse
T15195	23635-23638	VBD	denotes	was
T15194	23639-23643	VBN	denotes	made
T15196	23644-23646	TO	denotes	to
T15197	23647-23652	VB	denotes	grasp
T15198	23653-23656	DT	denotes	the
T15200	23657-23665	VBN	denotes	attached
T15199	23666-23669	NN	denotes	bar
T15201	23670-23671	-LRB-	denotes	(
T15203	23671-23672	CD	denotes	2
T15204	23673-23675	NN	denotes	mm
T15202	23676-23684	NN	denotes	diameter
T15205	23684-23685	-RRB-	denotes	)
T15206	23686-23690	IN	denotes	with
T15207	23691-23694	DT	denotes	the
T15208	23695-23703	NNS	denotes	forepaws
T15209	23704-23707	CC	denotes	and
T15210	23708-23711	VBD	denotes	was
T15212	23712-23718	RB	denotes	slowly
T15211	23719-23725	VBN	denotes	pulled
T15213	23726-23730	RB	denotes	back
T15214	23731-23733	IN	denotes	by
T15215	23734-23737	DT	denotes	the
T15216	23738-23742	NN	denotes	tail
T15217	23742-23743	.	denotes	.
T15218	23743-23792	sentence	denotes	The maximum tension before release was recorded.
T15219	23744-23747	DT	denotes	The
T15221	23748-23755	JJ	denotes	maximum
T15220	23756-23763	NN	denotes	tension
T15223	23764-23770	IN	denotes	before
T15224	23771-23778	NN	denotes	release
T15225	23779-23782	VBD	denotes	was
T15222	23783-23791	VBN	denotes	recorded
T15226	23791-23792	.	denotes	.
T15486	23794-23798	NN	denotes	Wire
T15487	23799-23809	NN	denotes	suspension
T15488	23810-23814	NN	denotes	test
T15489	23814-24007	sentence	denotes	A mouse was placed on a stainless bar (50 cm length, 2 mm diameter, elevated up to 37 cm from a surface) at a point midway between the supports and observed for 30 sec in four separate trials.
T15490	23815-23816	DT	denotes	A
T15491	23817-23822	NN	denotes	mouse
T15493	23823-23826	VBD	denotes	was
T15492	23827-23833	VBN	denotes	placed
T15494	23834-23836	IN	denotes	on
T15495	23837-23838	DT	denotes	a
T15497	23839-23848	JJ	denotes	stainless
T15496	23849-23852	NN	denotes	bar
T15498	23853-23854	-LRB-	denotes	(
T15500	23854-23856	CD	denotes	50
T15501	23857-23859	NN	denotes	cm
T15502	23860-23866	NN	denotes	length
T15503	23866-23868	,	denotes	,
T15504	23868-23869	CD	denotes	2
T15505	23870-23872	NN	denotes	mm
T15499	23873-23881	NN	denotes	diameter
T15506	23881-23883	,	denotes	,
T15507	23883-23891	VBN	denotes	elevated
T15508	23892-23894	RB	denotes	up
T15510	23895-23897	IN	denotes	to
T15509	23898-23900	CD	denotes	37
T15511	23901-23903	NN	denotes	cm
T15512	23904-23908	IN	denotes	from
T15513	23909-23910	DT	denotes	a
T15514	23911-23918	NN	denotes	surface
T15515	23918-23919	-RRB-	denotes	)
T15516	23920-23922	IN	denotes	at
T15517	23923-23924	DT	denotes	a
T15519	23925-23930	NN	denotes	point
T15518	23931-23937	NN	denotes	midway
T15520	23938-23945	IN	denotes	between
T15521	23946-23949	DT	denotes	the
T15522	23950-23958	NNS	denotes	supports
T15523	23959-23962	CC	denotes	and
T15524	23963-23971	VBN	denotes	observed
T15525	23972-23975	IN	denotes	for
T15526	23976-23978	CD	denotes	30
T15527	23979-23982	NN	denotes	sec
T15528	23983-23985	IN	denotes	in
T15529	23986-23990	CD	denotes	four
T15531	23991-23999	JJ	denotes	separate
T15530	24000-24006	NNS	denotes	trials
T15532	24006-24007	.	denotes	.
T15533	24007-24386	sentence	denotes	The amount of time spent hanging was recorded and scored according to the following system [41]: 0, fell off; 1, hung onto the bar with two forepaws; 2, in addition to 1, attempted to climb onto the bar; 3, hung onto the bar with two forepaws and one or both hind paws; 4, hung onto the bar with all four paws with tail wrapped around the bar; 5, escaped to one of the supports.
T15534	24008-24011	DT	denotes	The
T15535	24012-24018	NN	denotes	amount
T15537	24019-24021	IN	denotes	of
T15538	24022-24026	NN	denotes	time
T15539	24027-24032	VBN	denotes	spent
T15540	24033-24040	VBG	denotes	hanging
T15541	24041-24044	VBD	denotes	was
T15536	24045-24053	VBN	denotes	recorded
T15542	24054-24057	CC	denotes	and
T15543	24058-24064	VBN	denotes	scored
T15544	24065-24074	VBG	denotes	according
T15545	24075-24077	IN	denotes	to
T15546	24078-24081	DT	denotes	the
T15548	24082-24091	VBG	denotes	following
T15547	24092-24098	NN	denotes	system
T15549	24099-24100	-LRB-	denotes	[
T15550	24100-24102	CD	denotes	41
T15551	24102-24103	-RRB-	denotes	]
T15552	24103-24105	:	denotes	:
T15553	24105-24106	CD	denotes	0
T15555	24106-24108	,	denotes	,
T15554	24108-24112	VBD	denotes	fell
T15557	24113-24116	RP	denotes	off
T15558	24116-24117	:	denotes	;
T15559	24118-24119	CD	denotes	1
T15561	24119-24121	,	denotes	,
T15560	24121-24125	VBD	denotes	hung
T15562	24126-24130	IN	denotes	onto
T15563	24131-24134	DT	denotes	the
T15564	24135-24138	NN	denotes	bar
T15565	24139-24143	IN	denotes	with
T15566	24144-24147	CD	denotes	two
T15567	24148-24156	NNS	denotes	forepaws
T15568	24156-24157	:	denotes	;
T15569	24158-24159	CD	denotes	2
T15571	24159-24161	,	denotes	,
T15572	24161-24163	IN	denotes	in
T15573	24164-24172	NN	denotes	addition
T15574	24173-24175	IN	denotes	to
T15575	24176-24177	CD	denotes	1
T15576	24177-24179	,	denotes	,
T15570	24179-24188	VBD	denotes	attempted
T15577	24189-24191	TO	denotes	to
T15578	24192-24197	VB	denotes	climb
T15579	24198-24202	IN	denotes	onto
T15580	24203-24206	DT	denotes	the
T15581	24207-24210	NN	denotes	bar
T15582	24210-24211	:	denotes	;
T15583	24212-24213	CD	denotes	3
T15585	24213-24215	,	denotes	,
T15584	24215-24219	VBD	denotes	hung
T15586	24220-24224	IN	denotes	onto
T15587	24225-24228	DT	denotes	the
T15588	24229-24232	NN	denotes	bar
T15589	24233-24237	IN	denotes	with
T15590	24238-24241	CD	denotes	two
T15591	24242-24250	NNS	denotes	forepaws
T15592	24251-24254	CC	denotes	and
T15593	24255-24258	CD	denotes	one
T15595	24259-24261	CC	denotes	or
T15596	24262-24266	CC	denotes	both
T15597	24267-24271	NN	denotes	hind
T15594	24272-24276	NNS	denotes	paws
T15598	24276-24277	:	denotes	;
T15599	24278-24279	CD	denotes	4
T15601	24279-24281	,	denotes	,
T15600	24281-24285	VBD	denotes	hung
T15602	24286-24290	IN	denotes	onto
T15603	24291-24294	DT	denotes	the
T15604	24295-24298	NN	denotes	bar
T15605	24299-24303	IN	denotes	with
T15606	24304-24307	DT	denotes	all
T15608	24308-24312	CD	denotes	four
T15607	24313-24317	NNS	denotes	paws
T15609	24318-24322	IN	denotes	with
T15610	24323-24327	NN	denotes	tail
T15611	24328-24335	VBN	denotes	wrapped
T15612	24336-24342	IN	denotes	around
T15613	24343-24346	DT	denotes	the
T15614	24347-24350	NN	denotes	bar
T15615	24350-24351	:	denotes	;
T15616	24352-24353	CD	denotes	5
T15617	24353-24355	,	denotes	,
T15556	24355-24362	VBD	denotes	escaped
T15618	24363-24365	IN	denotes	to
T15619	24366-24369	CD	denotes	one
T15620	24370-24372	IN	denotes	of
T15621	24373-24376	DT	denotes	the
T15622	24377-24385	NNS	denotes	supports
T15623	24385-24386	.	denotes	.
T15705	24388-24397	NN	denotes	Footprint
T15706	24398-24402	NN	denotes	test
T15707	24402-24531	sentence	denotes	Black ink was applied to the hind paws of each mouse and the mice were placed in a narrow alley (9 × 25 × 10 cm) on white paper.
T15708	24403-24408	JJ	denotes	Black
T15709	24409-24412	NN	denotes	ink
T15711	24413-24416	VBD	denotes	was
T15710	24417-24424	VBN	denotes	applied
T15712	24425-24427	IN	denotes	to
T15713	24428-24431	DT	denotes	the
T15715	24432-24436	NN	denotes	hind
T15714	24437-24441	NNS	denotes	paws
T15716	24442-24444	IN	denotes	of
T15717	24445-24449	DT	denotes	each
T15718	24450-24455	NN	denotes	mouse
T15719	24456-24459	CC	denotes	and
T15720	24460-24463	DT	denotes	the
T15721	24464-24468	NNS	denotes	mice
T15723	24469-24473	VBD	denotes	were
T15722	24474-24480	VBN	denotes	placed
T15724	24481-24483	IN	denotes	in
T15725	24484-24485	DT	denotes	a
T15727	24486-24492	JJ	denotes	narrow
T15726	24493-24498	NN	denotes	alley
T15728	24499-24500	-LRB-	denotes	(
T15730	24500-24501	CD	denotes	9
T15732	24502-24503	SYM	denotes	×
T15733	24504-24506	CD	denotes	25
T15734	24507-24508	SYM	denotes	×
T15731	24509-24511	CD	denotes	10
T15729	24512-24514	NN	denotes	cm
T15735	24514-24515	-RRB-	denotes	)
T15736	24516-24518	IN	denotes	on
T15737	24519-24524	JJ	denotes	white
T15738	24525-24530	NN	denotes	paper
T15739	24530-24531	.	denotes	.
T15740	24531-24577	sentence	denotes	Stride length and step width were calculated.
T15741	24532-24538	NN	denotes	Stride
T15742	24539-24545	NN	denotes	length
T15744	24546-24549	CC	denotes	and
T15745	24550-24554	NN	denotes	step
T15746	24555-24560	NN	denotes	width
T15747	24561-24565	VBD	denotes	were
T15743	24566-24576	VBN	denotes	calculated
T15748	24576-24577	.	denotes	.
T15949	24579-24589	NNS	denotes	Statistics
T15950	24589-24628	sentence	denotes	Data are expressed as the means ± SEM.
T15951	24590-24594	NNS	denotes	Data
T15953	24595-24598	VBP	denotes	are
T15952	24599-24608	VBN	denotes	expressed
T15954	24609-24611	IN	denotes	as
T15955	24612-24615	DT	denotes	the
T15957	24616-24621	NNS	denotes	means
T15958	24622-24623	SYM	denotes	±
T15956	24624-24627	NN	denotes	SEM
T15959	24627-24628	.	denotes	.
T15960	24628-24740	sentence	denotes	Statistical analysis was conducted using the software package SAS 8.1 (SAS Institute Japan Ltd., Tokyo, Japan).
T15961	24629-24640	JJ	denotes	Statistical
T15962	24641-24649	NN	denotes	analysis
T15964	24650-24653	VBD	denotes	was
T15963	24654-24663	VBN	denotes	conducted
T15965	24664-24669	VBG	denotes	using
T15966	24670-24673	DT	denotes	the
T15968	24674-24682	NN	denotes	software
T15967	24683-24690	NN	denotes	package
T15969	24691-24694	NN	denotes	SAS
T15970	24695-24698	CD	denotes	8.1
T15971	24699-24700	-LRB-	denotes	(
T15973	24700-24703	NNP	denotes	SAS
T15974	24704-24713	NNP	denotes	Institute
T15972	24714-24719	NNP	denotes	Japan
T15975	24720-24724	NNP	denotes	Ltd.
T15976	24724-24726	,	denotes	,
T15977	24726-24731	NNP	denotes	Tokyo
T15978	24731-24733	,	denotes	,
T15979	24733-24738	NNP	denotes	Japan
T15980	24738-24739	-RRB-	denotes	)
T15981	24739-24740	.	denotes	.
T15982	24740-24956	sentence	denotes	Statistical significance was determined by analysis of variance (ANOVA) followed by the Dunnett-type multiple comparison test, and p values of less than 0.05 were considered to be significant in the water maze task.
T15983	24741-24752	JJ	denotes	Statistical
T15984	24753-24765	NN	denotes	significance
T15986	24766-24769	VBD	denotes	was
T15985	24770-24780	VBN	denotes	determined
T15987	24781-24783	IN	denotes	by
T15988	24784-24792	NN	denotes	analysis
T15989	24793-24795	IN	denotes	of
T15990	24796-24804	NN	denotes	variance
T15991	24805-24806	-LRB-	denotes	(
T15992	24806-24811	NN	denotes	ANOVA
T15993	24811-24812	-RRB-	denotes	)
T15994	24813-24821	VBN	denotes	followed
T15995	24822-24824	IN	denotes	by
T15996	24825-24828	DT	denotes	the
T15998	24829-24836	NNP	denotes	Dunnett
T16000	24836-24837	HYPH	denotes	-
T15999	24837-24841	NN	denotes	type
T16001	24842-24850	JJ	denotes	multiple
T16002	24851-24861	NN	denotes	comparison
T15997	24862-24866	NN	denotes	test
T16003	24866-24868	,	denotes	,
T16004	24868-24871	CC	denotes	and
T16005	24872-24873	NN	denotes	p
T16006	24874-24880	NNS	denotes	values
T16008	24881-24883	IN	denotes	of
T16009	24884-24888	JJR	denotes	less
T16011	24889-24893	IN	denotes	than
T16010	24894-24898	CD	denotes	0.05
T16012	24899-24903	VBD	denotes	were
T16007	24904-24914	VBN	denotes	considered
T16013	24915-24917	TO	denotes	to
T16014	24918-24920	VB	denotes	be
T16015	24921-24932	JJ	denotes	significant
T16016	24933-24935	IN	denotes	in
T16017	24936-24939	DT	denotes	the
T16019	24940-24945	NN	denotes	water
T16020	24946-24950	NN	denotes	maze
T16018	24951-24955	NN	denotes	task
T16021	24955-24956	.	denotes	.
T16022	24956-25127	sentence	denotes	Behavioural data in the rotating rod test were analysed by one- or two-way ANOVA with repeated measures, and p values of less than 0.05 were considered to be significant.
T16023	24957-24968	JJ	denotes	Behavioural
T16024	24969-24973	NNS	denotes	data
T16026	24974-24976	IN	denotes	in
T16027	24977-24980	DT	denotes	the
T16029	24981-24989	VBG	denotes	rotating
T16030	24990-24993	NN	denotes	rod
T16028	24994-24998	NN	denotes	test
T16031	24999-25003	VBD	denotes	were
T16025	25004-25012	VBN	denotes	analysed
T16032	25013-25015	IN	denotes	by
T16033	25016-25019	CD	denotes	one
T16035	25019-25020	HYPH	denotes	-
T16036	25021-25023	CC	denotes	or
T16037	25024-25027	CD	denotes	two
T16038	25027-25028	HYPH	denotes	-
T16034	25028-25031	NN	denotes	way
T16039	25032-25037	NN	denotes	ANOVA
T16040	25038-25042	IN	denotes	with
T16041	25043-25051	VBN	denotes	repeated
T16042	25052-25060	NNS	denotes	measures
T16043	25060-25062	,	denotes	,
T16044	25062-25065	CC	denotes	and
T16045	25066-25067	NN	denotes	p
T16046	25068-25074	NNS	denotes	values
T16048	25075-25077	IN	denotes	of
T16049	25078-25082	JJR	denotes	less
T16051	25083-25087	IN	denotes	than
T16050	25088-25092	CD	denotes	0.05
T16052	25093-25097	VBD	denotes	were
T16047	25098-25108	VBN	denotes	considered
T16053	25109-25111	TO	denotes	to
T16054	25112-25114	VB	denotes	be
T16055	25115-25126	JJ	denotes	significant
T16056	25126-25127	.	denotes	.
T16221	25129-25143	NN	denotes	Histopathology
T16222	25143-25364	sentence	denotes	Sections of tissues including the brain, spinal cord, heart, lung, liver, kidney, spleen and testis from mice (+/+, +/- and -/-; n = 7, 7 and 7, respectively) were fixed in 10% buffered formalin and embedded in paraffin.
T16223	25144-25152	NNS	denotes	Sections
T16225	25153-25155	IN	denotes	of
T16226	25156-25163	NNS	denotes	tissues
T16227	25164-25173	VBG	denotes	including
T16228	25174-25177	DT	denotes	the
T16229	25178-25183	NN	denotes	brain
T16230	25183-25185	,	denotes	,
T16231	25185-25191	JJ	denotes	spinal
T16232	25192-25196	NN	denotes	cord
T16233	25196-25198	,	denotes	,
T16234	25198-25203	NN	denotes	heart
T16235	25203-25205	,	denotes	,
T16236	25205-25209	NN	denotes	lung
T16237	25209-25211	,	denotes	,
T16238	25211-25216	NN	denotes	liver
T16239	25216-25218	,	denotes	,
T16240	25218-25224	NN	denotes	kidney
T16241	25224-25226	,	denotes	,
T16242	25226-25232	NN	denotes	spleen
T16243	25233-25236	CC	denotes	and
T16244	25237-25243	NN	denotes	testis
T16245	25244-25248	IN	denotes	from
T16246	25249-25253	NNS	denotes	mice
T16247	25254-25255	-LRB-	denotes	(
T16249	25255-25256	SYM	denotes	+
T16250	25256-25257	HYPH	denotes	/
T16248	25257-25258	SYM	denotes	+
T16251	25258-25260	,	denotes	,
T16252	25260-25261	SYM	denotes	+
T16254	25261-25262	HYPH	denotes	/
T16253	25262-25263	SYM	denotes	-
T16255	25264-25267	CC	denotes	and
T16256	25268-25269	SYM	denotes	-
T16258	25269-25270	HYPH	denotes	/
T16257	25270-25271	SYM	denotes	-
T16259	25271-25272	:	denotes	;
T16260	25273-25274	NN	denotes	n
T16262	25275-25276	SYM	denotes	=
T16261	25277-25278	CD	denotes	7
T16263	25278-25280	,	denotes	,
T16264	25280-25281	CD	denotes	7
T16265	25282-25285	CC	denotes	and
T16266	25286-25287	CD	denotes	7
T16267	25287-25289	,	denotes	,
T16268	25289-25301	RB	denotes	respectively
T16269	25301-25302	-RRB-	denotes	)
T16270	25303-25307	VBD	denotes	were
T16224	25308-25313	VBN	denotes	fixed
T16271	25314-25316	IN	denotes	in
T16272	25317-25319	CD	denotes	10
T16273	25319-25320	NN	denotes	%
T16275	25321-25329	VBN	denotes	buffered
T16274	25330-25338	NN	denotes	formalin
T16276	25339-25342	CC	denotes	and
T16277	25343-25351	VBN	denotes	embedded
T16278	25352-25354	IN	denotes	in
T16279	25355-25363	NN	denotes	paraffin
T16280	25363-25364	.	denotes	.
T16281	25364-25445	sentence	denotes	Each paraffin section of thick 4 μm was stained with hematoxylin and eosin (HE).
T16282	25365-25369	DT	denotes	Each
T16284	25370-25378	NN	denotes	paraffin
T16283	25379-25386	NN	denotes	section
T16286	25387-25389	IN	denotes	of
T16287	25390-25395	JJ	denotes	thick
T16289	25396-25397	CD	denotes	4
T16288	25398-25400	NN	denotes	μm
T16290	25401-25404	VBD	denotes	was
T16285	25405-25412	VBN	denotes	stained
T16291	25413-25417	IN	denotes	with
T16292	25418-25429	NN	denotes	hematoxylin
T16293	25430-25433	CC	denotes	and
T16294	25434-25439	NN	denotes	eosin
T16295	25440-25441	-LRB-	denotes	(
T16296	25441-25443	NN	denotes	HE
T16297	25443-25444	-RRB-	denotes	)
T16298	25444-25445	.	denotes	.
R10	T575	T577	amod	deficient,mice
R100	T678	T657	punct	.,were
R1000	T4029	T4030	punct	(,shown
R1001	T4030	T4019	parataxis	shown,was
R1002	T4031	T4030	nsubj	data,shown
R1003	T4032	T4030	neg	not,shown
R1004	T4033	T4030	punct	),shown
R1005	T4034	T4019	punct	.,was
R1006	T4036	T4037	prep	For,used
R1007	T4038	T4039	det	the,experiments
R1008	T4039	T4036	pobj	experiments,For
R1009	T4040	T4039	amod	present,experiments
R101	T680	T681	mark	Because,is
R1010	T4041	T4037	punct	", ",used
R1011	T4042	T4043	npadvmod	ADAM11,deficient
R1012	T4043	T4045	amod	deficient,mice
R1013	T4044	T4043	punct	-,deficient
R1014	T4045	T4037	nsubjpass	mice,used
R1015	T4046	T4045	amod	male,mice
R1016	T4047	T4048	punct	(,generations
R1017	T4048	T4045	parataxis	generations,mice
R1018	T4049	T4048	amod	backcrossed,generations
R1019	T4050	T4048	prep	into,generations
R102	T681	T683	advcl	is,examined
R1020	T4051	T4052	compound	C57BL,6NCrj
R1021	T4052	T4050	pobj	6NCrj,into
R1022	T4053	T4052	punct	/,6NCrj
R1023	T4054	T4048	punct	", ",generations
R1024	T4055	T4056	nsubj	n,14
R1025	T4056	T4048	ccomp	14,generations
R1026	T4057	T4056	punct	=,14
R1027	T4058	T4048	punct	),generations
R1028	T4059	T4037	auxpass	were,used
R1029	T4060	T4037	prep	in,used
R103	T682	T681	nsubj	ADAM11,is
R1030	T4061	T4062	det	all,analyses
R1031	T4062	T4060	pobj	analyses,in
R1032	T4063	T4062	amod	behavioural,analyses
R1033	T4064	T4062	cc	and,analyses
R1034	T4065	T4066	amod	anatomical,histological
R1035	T4066	T4068	amod	histological,studies
R1036	T4067	T4066	punct	-,histological
R1037	T4068	T4062	conj	studies,analyses
R1038	T4069	T4037	punct	.,used
R1039	T4071	T4072	amod	Homozygous,mice
R104	T684	T685	advmod	highly,expressed
R1040	T4072	T4076	nsubj	mice,were
R1041	T4073	T4074	npadvmod	ADAM11,deficient
R1042	T4074	T4072	amod	deficient,mice
R1043	T4075	T4074	punct	-,deficient
R1044	T4077	T4076	acomp	viable,were
R1045	T4078	T4076	cc	and,were
R1046	T4079	T4076	conj	appeared,were
R1047	T4080	T4079	oprd	normal,appeared
R1048	T4081	T4076	punct	", ",were
R1049	T4082	T4076	advcl	indicating,were
R105	T685	T681	acomp	expressed,is
R1050	T4083	T4084	mark	that,is
R1051	T4084	T4082	ccomp	is,indicating
R1052	T4085	T4086	det	the,gene
R1053	T4086	T4084	nsubj	gene,is
R1054	T4087	T4086	compound	Adam11,gene
R1055	T4088	T4084	neg	not,is
R1056	T4089	T4084	acomp	essential,is
R1057	T4090	T4089	prep	to,essential
R1058	T4091	T4090	pobj	development,to
R1059	T4092	T4091	cc	and,development
R106	T686	T681	prep	in,is
R1060	T4093	T4091	conj	survival,development
R1061	T4094	T4076	punct	.,were
R1062	T4096	T4097	det	The,gain
R1063	T4097	T4098	nsubj	gain,was
R1064	T4099	T4097	prep	in,gain
R1065	T4100	T4101	compound	body,weight
R1066	T4101	T4099	pobj	weight,in
R1067	T4102	T4097	prep	of,gain
R1068	T4103	T4104	punct	(,mice
R1069	T4104	T4102	pobj	mice,of
R107	T687	T688	det	the,hippocampus
R1070	T4105	T4106	punct	-,-
R1071	T4106	T4104	punct	-,mice
R1072	T4107	T4106	punct	/,-
R1073	T4108	T4104	punct	),mice
R1074	T4109	T4098	acomp	comparable,was
R1075	T4110	T4109	prep	to,comparable
R1076	T4111	T4110	pobj	that,to
R1077	T4112	T4111	prep	of,that
R1078	T4113	T4114	punct	(,mice
R1079	T4114	T4112	pobj	mice,of
R108	T688	T686	pobj	hippocampus,in
R1080	T4115	T4116	punct	+,+
R1081	T4116	T4114	punct	+,mice
R1082	T4117	T4116	punct	/,+
R1083	T4118	T4116	punct	),+
R1084	T4119	T4116	cc	and,+
R1085	T4120	T4121	punct	(,-
R1086	T4121	T4116	conj	-,+
R1087	T4122	T4121	punct	+,-
R1088	T4123	T4121	punct	/,-
R1089	T4124	T4114	punct	),mice
R109	T689	T688	cc	and,hippocampus
R1090	T4125	T4126	advmod	at,least
R1091	T4126	T4127	advmod	least,until
R1092	T4127	T4098	prep	until,was
R1093	T4128	T4129	nummod	24,weeks
R1094	T4129	T4127	pobj	weeks,until
R1095	T4130	T4129	prep	of,weeks
R1096	T4131	T4130	pobj	age,of
R1097	T4132	T4133	punct	(,shown
R1098	T4133	T4098	parataxis	shown,was
R1099	T4134	T4133	nsubj	data,shown
R11	T576	T575	punct	-,deficient
R110	T690	T688	conj	cerebellum,hippocampus
R1100	T4135	T4133	neg	not,shown
R1101	T4136	T4133	punct	),shown
R1102	T4137	T4098	punct	.,was
R1103	T4139	T4140	expl	There,was
R1104	T4141	T4142	det	no,difference
R1105	T4142	T4140	attr	difference,was
R1106	T4143	T4142	amod	significant,difference
R1107	T4144	T4142	prep	in,difference
R1108	T4145	T4146	compound	locomotor,activity
R1109	T4146	T4144	pobj	activity,in
R111	T691	T683	punct	", ",examined
R1110	T4147	T4142	prep	among,difference
R1111	T4148	T4149	punct	(,genotypes
R1112	T4149	T4147	pobj	genotypes,among
R1113	T4150	T4151	punct	+,+
R1114	T4151	T4149	punct	+,genotypes
R1115	T4152	T4151	punct	/,+
R1116	T4153	T4151	punct	),+
R1117	T4154	T4151	punct	", ",+
R1118	T4155	T4156	punct	(,-
R1119	T4156	T4151	conj	-,+
R112	T692	T683	nsubj	we,examined
R1120	T4157	T4156	punct	+,-
R1121	T4158	T4156	punct	/,-
R1122	T4159	T4156	punct	),-
R1123	T4160	T4156	cc	and,-
R1124	T4161	T4162	punct	(,-
R1125	T4162	T4156	conj	-,-
R1126	T4163	T4162	punct	-,-
R1127	T4164	T4162	punct	/,-
R1128	T4165	T4149	punct	),genotypes
R1129	T4166	T4167	punct	(,shown
R113	T693	T683	aux	have,examined
R1130	T4167	T4140	parataxis	shown,was
R1131	T4168	T4167	nsubj	data,shown
R1132	T4169	T4167	neg	not,shown
R1133	T4170	T4167	punct	),shown
R1134	T4171	T4140	punct	.,was
R1135	T4173	T4174	det	No,change
R1136	T4174	T4179	nsubjpass	change,observed
R1137	T4175	T4174	amod	apparent,change
R1138	T4176	T4177	amod	anatomical,histological
R1139	T4177	T4174	amod	histological,change
R114	T694	T695	compound	ADAM11,mice
R1140	T4178	T4177	punct	-,histological
R1141	T4180	T4179	auxpass	was,observed
R1142	T4181	T4179	prep	in,observed
R1143	T4182	T4183	det	the,cord
R1144	T4183	T4181	pobj	cord,in
R1145	T4184	T4183	amod	spinal,cord
R1146	T4185	T4183	punct	", ",cord
R1147	T4186	T4183	conj	heart,cord
R1148	T4187	T4186	punct	", ",heart
R1149	T4188	T4186	conj	lung,heart
R115	T695	T683	dobj	mice,examined
R1150	T4189	T4188	punct	", ",lung
R1151	T4190	T4188	conj	liver,lung
R1152	T4191	T4190	punct	", ",liver
R1153	T4192	T4190	conj	kidney,liver
R1154	T4193	T4192	punct	", ",kidney
R1155	T4194	T4192	conj	spleen,kidney
R1156	T4195	T4194	punct	", ",spleen
R1157	T4196	T4194	conj	testis,spleen
R1158	T4197	T4196	cc	or,testis
R1159	T4198	T4196	conj	ovary,testis
R116	T696	T695	compound	mutant,mice
R1160	T4199	T4200	punct	(,shown
R1161	T4200	T4179	parataxis	shown,observed
R1162	T4201	T4200	nsubj	data,shown
R1163	T4202	T4200	neg	not,shown
R1164	T4203	T4200	punct	),shown
R1165	T4204	T4179	punct	.,observed
R1166	T4206	T4207	det	The,brain
R1167	T4207	T4208	nsubj	brain,appeared
R1168	T4209	T4207	prep	of,brain
R1169	T4210	T4211	punct	(,mice
R117	T697	T683	prep	for,examined
R1170	T4211	T4209	pobj	mice,of
R1171	T4212	T4213	punct	-,-
R1172	T4213	T4211	punct	-,mice
R1173	T4214	T4213	punct	/,-
R1174	T4215	T4211	punct	),mice
R1175	T4216	T4207	punct	", ",brain
R1176	T4217	T4207	prep	including,brain
R1177	T4218	T4219	det	the,hippocampus
R1178	T4219	T4217	pobj	hippocampus,including
R1179	T4220	T4221	punct	(,1D
R118	T698	T697	pobj	learning,for
R1180	T4221	T4219	parataxis	1D,hippocampus
R1181	T4222	T4221	compound	Fig.,1D
R1182	T4223	T4221	punct	),1D
R1183	T4224	T4219	cc	and,hippocampus
R1184	T4225	T4219	conj	cerebellum,hippocampus
R1185	T4226	T4227	punct	(,1E
R1186	T4227	T4225	parataxis	1E,cerebellum
R1187	T4228	T4227	compound	Fig.,1E
R1188	T4229	T4227	punct	),1E
R1189	T4230	T4208	oprd	normal,appeared
R119	T699	T683	advcl	using,examined
R1190	T4231	T4208	prep	after,appeared
R1191	T4232	T4233	compound	HE,staining
R1192	T4233	T4231	pobj	staining,after
R1193	T4234	T4235	advmod	when,compared
R1194	T4235	T4208	advcl	compared,appeared
R1195	T4236	T4237	punct	(,mice
R1196	T4237	T4235	nsubjpass	mice,compared
R1197	T4238	T4239	punct	+,+
R1198	T4239	T4237	punct	+,mice
R1199	T4240	T4239	punct	/,+
R12	T577	T573	pobj	mice,in
R120	T700	T701	amod	visual,tasks
R1200	T4241	T4239	punct	),+
R1201	T4242	T4239	punct	", ",+
R1202	T4243	T4244	punct	(,-
R1203	T4244	T4239	conj	-,+
R1204	T4245	T4244	punct	+,-
R1205	T4246	T4244	punct	/,-
R1206	T4247	T4244	punct	),-
R1207	T4248	T4244	cc	and,-
R1208	T4249	T4250	punct	(,-
R1209	T4250	T4244	conj	-,-
R121	T701	T699	dobj	tasks,using
R1210	T4251	T4250	punct	-,-
R1211	T4252	T4250	punct	/,-
R1212	T4253	T4237	punct	),mice
R1213	T4254	T4235	auxpass	were,compared
R1214	T4255	T4208	punct	.,appeared
R1215	T4257	T4258	mark	Since,expressed
R1216	T4258	T4262	advcl	expressed,applied
R1217	T4259	T4258	nsubjpass	Adam11,expressed
R1218	T4260	T4258	auxpass	is,expressed
R1219	T4261	T4258	advmod	predominantly,expressed
R122	T702	T700	cc	and,visual
R1220	T4263	T4258	prep	in,expressed
R1221	T4264	T4265	det	the,hippocampus
R1222	T4265	T4263	pobj	hippocampus,in
R1223	T4266	T4265	cc	and,hippocampus
R1224	T4267	T4265	conj	cerebellum,hippocampus
R1225	T4268	T4262	punct	", ",applied
R1226	T4269	T4262	nsubj	we,applied
R1227	T4270	T4271	npadvmod	hippocampus,dependent
R1228	T4271	T4276	amod	dependent,analyses
R1229	T4272	T4270	punct	-,hippocampus
R123	T703	T700	conj	hidden,visual
R1230	T4273	T4270	cc	or,hippocampus
R1231	T4274	T4270	conj	cerebellum,hippocampus
R1232	T4275	T4271	punct	-,dependent
R1233	T4276	T4262	dobj	analyses,applied
R1234	T4277	T4276	amod	behavioural,analyses
R1235	T4278	T4262	punct	.,applied
R1236	T5242	T5243	amod	Spatial,learning
R1237	T5244	T5243	prep	in,learning
R1238	T5245	T5246	npadvmod	ADAM11,deficient
R1239	T5246	T5248	amod	deficient,mice
R124	T704	T705	compound	water,maze
R1240	T5247	T5246	punct	-,deficient
R1241	T5248	T5244	pobj	mice,in
R1242	T5250	T5251	aux	To,study
R1243	T5251	T5252	advcl	study,examined
R1244	T5253	T5254	det	the,functions
R1245	T5254	T5251	dobj	functions,study
R1246	T5255	T5254	prep	of,functions
R1247	T5256	T5255	pobj	ADAM11,of
R1248	T5257	T5251	prep	in,study
R1249	T5258	T5259	det	the,hippocampus
R125	T705	T701	compound	maze,tasks
R1250	T5259	T5257	pobj	hippocampus,in
R1251	T5260	T5252	punct	", ",examined
R1252	T5261	T5252	nsubj	we,examined
R1253	T5262	T5263	det	the,ability
R1254	T5263	T5252	dobj	ability,examined
R1255	T5264	T5265	amod	spatial,learning
R1256	T5265	T5263	compound	learning,ability
R1257	T5266	T5263	prep	of,ability
R1258	T5267	T5268	npadvmod	ADAM11,deficient
R1259	T5268	T5270	amod	deficient,mice
R126	T706	T683	punct	", ",examined
R1260	T5269	T5268	punct	-,deficient
R1261	T5270	T5266	pobj	mice,of
R1262	T5271	T5252	advcl	using,examined
R1263	T5272	T5273	det	the,task
R1264	T5273	T5271	dobj	task,using
R1265	T5274	T5275	compound	Morris,Maze
R1266	T5275	T5273	compound	Maze,task
R1267	T5276	T5275	compound	Water,Maze
R1268	T5277	T5278	punct	[,27
R1269	T5278	T5271	parataxis	27,using
R127	T707	T683	cc	and,examined
R1270	T5279	T5278	punct	],27
R1271	T5280	T5252	punct	.,examined
R1272	T5282	T5283	advmod	First,trained
R1273	T5284	T5283	punct	", ",trained
R1274	T5285	T5283	nsubjpass	mice,trained
R1275	T5286	T5283	auxpass	were,trained
R1276	T5287	T5283	prep	in,trained
R1277	T5288	T5289	det	a,task
R1278	T5289	T5287	pobj	task,in
R1279	T5290	T5291	amod	hidden,platform
R128	T708	T709	poss	their,coordination
R1280	T5291	T5289	compound	platform,task
R1281	T5292	T5289	punct	", ",task
R1282	T5293	T5294	prep	in,searched
R1283	T5294	T5289	relcl	searched,task
R1284	T5295	T5293	pobj	which,in
R1285	T5296	T5294	nsubj	mice,searched
R1286	T5297	T5294	prep	for,searched
R1287	T5298	T5299	det	a,platform
R1288	T5299	T5297	pobj	platform,for
R1289	T5300	T5299	amod	submerged,platform
R129	T709	T683	conj	coordination,examined
R1290	T5301	T5302	aux	to,escape
R1291	T5302	T5294	advcl	escape,searched
R1292	T5303	T5302	prep	from,escape
R1293	T5304	T5305	det	the,water
R1294	T5305	T5303	pobj	water,from
R1295	T5306	T5283	punct	.,trained
R1296	T5308	T5309	nmod	Adam11,mice
R1297	T5309	T5315	nsubjpass	mice,found
R1298	T5310	T5308	punct	(,Adam11
R1299	T5311	T5308	punct	-,Adam11
R13	T582	T583	nsubj	ADAM11,is
R130	T710	T709	amod	motor,coordination
R1300	T5312	T5308	punct	/,Adam11
R1301	T5313	T5308	punct	-,Adam11
R1302	T5314	T5308	punct	),Adam11
R1303	T5316	T5315	auxpass	were,found
R1304	T5317	T5318	aux	to,take
R1305	T5318	T5315	xcomp	take,found
R1306	T5319	T5320	det	a,time
R1307	T5320	T5318	dobj	time,take
R1308	T5321	T5322	advmod	significantly,longer
R1309	T5322	T5320	amod	longer,time
R131	T711	T709	advcl	using,coordination
R1310	T5323	T5324	aux	to,locate
R1311	T5324	T5320	advcl	locate,time
R1312	T5325	T5326	det	the,platform
R1313	T5326	T5324	dobj	platform,locate
R1314	T5327	T5326	amod	hidden,platform
R1315	T5328	T5320	prep	than,time
R1316	T5329	T5330	punct	(,mice
R1317	T5330	T5328	pobj	mice,than
R1318	T5331	T5332	punct	+,+
R1319	T5332	T5330	punct	+,mice
R132	T712	T713	det	a,task
R1320	T5333	T5332	punct	/,+
R1321	T5334	T5332	punct	),+
R1322	T5335	T5332	cc	and,+
R1323	T5336	T5337	punct	(,-
R1324	T5337	T5332	conj	-,+
R1325	T5338	T5337	punct	+,-
R1326	T5339	T5337	punct	/,-
R1327	T5340	T5330	punct	),mice
R1328	T5341	T5342	punct	(,2A
R1329	T5342	T5318	parataxis	2A,take
R133	T713	T711	dobj	task,using
R1330	T5343	T5342	compound	Fig.,2A
R1331	T5344	T5342	punct	),2A
R1332	T5345	T5315	punct	.,found
R1333	T5347	T5348	advmod	Nonetheless,improved
R1334	T5349	T5348	punct	", ",improved
R1335	T5350	T5351	det	the,ability
R1336	T5351	T5348	nsubj	ability,improved
R1337	T5352	T5351	prep	of,ability
R1338	T5353	T5354	punct	(,mice
R1339	T5354	T5352	pobj	mice,of
R134	T714	T715	amod	rotating,rod
R1340	T5355	T5356	punct	+,+
R1341	T5356	T5354	punct	+,mice
R1342	T5357	T5356	punct	/,+
R1343	T5358	T5356	punct	),+
R1344	T5359	T5356	punct	", ",+
R1345	T5360	T5361	punct	(,-
R1346	T5361	T5356	conj	-,+
R1347	T5362	T5361	punct	+,-
R1348	T5363	T5361	punct	/,-
R1349	T5364	T5361	punct	),-
R135	T715	T713	compound	rod,task
R1350	T5365	T5361	cc	and,-
R1351	T5366	T5367	punct	(,-
R1352	T5367	T5361	conj	-,-
R1353	T5368	T5367	punct	-,-
R1354	T5369	T5367	punct	/,-
R1355	T5370	T5354	punct	),mice
R1356	T5371	T5372	aux	to,find
R1357	T5372	T5351	acl	find,ability
R1358	T5373	T5374	det	the,platform
R1359	T5374	T5372	dobj	platform,find
R136	T716	T683	punct	.,examined
R1360	T5375	T5374	amod	hidden,platform
R1361	T5376	T5348	prep	over,improved
R1362	T5377	T5378	compound	test,sessions
R1363	T5378	T5376	pobj	sessions,over
R1364	T5379	T5380	punct	(,2A
R1365	T5380	T5348	parataxis	2A,improved
R1366	T5381	T5380	compound	Fig.,2A
R1367	T5382	T5380	punct	),2A
R1368	T5383	T5348	punct	.,improved
R1369	T5385	T5386	advmod	Thus,were
R137	T718	T719	poss	Our,results
R1370	T5387	T5386	punct	", ",were
R1371	T5388	T5389	punct	(,mice
R1372	T5389	T5386	nsubj	mice,were
R1373	T5390	T5391	punct	+,+
R1374	T5391	T5389	punct	+,mice
R1375	T5392	T5391	punct	/,+
R1376	T5393	T5391	punct	),+
R1377	T5394	T5391	punct	", ",+
R1378	T5395	T5396	punct	(,-
R1379	T5396	T5391	conj	-,+
R138	T719	T720	nsubj	results,showed
R1380	T5397	T5396	punct	+,-
R1381	T5398	T5396	punct	/,-
R1382	T5399	T5396	punct	),-
R1383	T5400	T5396	cc	and,-
R1384	T5401	T5402	punct	(,-
R1385	T5402	T5396	conj	-,-
R1386	T5403	T5402	punct	-,-
R1387	T5404	T5402	punct	/,-
R1388	T5405	T5389	punct	),mice
R1389	T5406	T5386	acomp	able,were
R139	T721	T722	mark	that,are
R1390	T5407	T5408	aux	to,learn
R1391	T5408	T5406	xcomp	learn,able
R1392	T5409	T5410	det	the,location
R1393	T5410	T5408	dobj	location,learn
R1394	T5411	T5410	prep	of,location
R1395	T5412	T5413	det	the,platform
R1396	T5413	T5411	pobj	platform,of
R1397	T5414	T5413	amod	hidden,platform
R1398	T5415	T5408	prep	during,learn
R1399	T5416	T5417	det	the,course
R14	T584	T585	det	a,member
R140	T722	T720	ccomp	are,showed
R1400	T5417	T5415	pobj	course,during
R1401	T5418	T5417	prep	of,course
R1402	T5419	T5420	det	the,trials
R1403	T5420	T5418	pobj	trials,of
R1404	T5421	T5386	punct	", ",were
R1405	T5422	T5423	mark	although,was
R1406	T5423	T5386	advcl	was,were
R1407	T5424	T5425	det	the,capacity
R1408	T5425	T5423	nsubj	capacity,was
R1409	T5426	T5425	prep	of,capacity
R141	T723	T724	poss	their,results
R1410	T5427	T5426	punct	(,of
R1411	T5428	T5429	punct	-,-
R1412	T5429	T5431	punct	-,mice
R1413	T5430	T5429	punct	/,-
R1414	T5431	T5426	pobj	mice,of
R1415	T5432	T5431	punct	),mice
R1416	T5433	T5434	aux	to,find
R1417	T5434	T5425	acl	find,capacity
R1418	T5435	T5436	det	the,platform
R1419	T5436	T5434	dobj	platform,find
R142	T724	T722	nsubj	results,are
R1420	T5437	T5423	acomp	lower,was
R1421	T5438	T5437	prep	than,lower
R1422	T5439	T5438	pobj	that,than
R1423	T5440	T5439	prep	of,that
R1424	T5441	T5442	punct	(,mice
R1425	T5442	T5440	pobj	mice,of
R1426	T5443	T5444	punct	+,+
R1427	T5444	T5442	punct	+,mice
R1428	T5445	T5444	punct	/,+
R1429	T5446	T5444	punct	),+
R143	T725	T726	amod	visual,maze
R1430	T5447	T5444	cc	and,+
R1431	T5448	T5449	punct	(,-
R1432	T5449	T5444	conj	-,+
R1433	T5450	T5449	punct	+,-
R1434	T5451	T5449	punct	/,-
R1435	T5452	T5442	punct	),mice
R1436	T5453	T5386	punct	.,were
R1437	T5455	T5456	nsubj	We,performed
R1438	T5457	T5456	advmod	further,performed
R1439	T5458	T5459	det	a,test
R144	T726	T728	compound	maze,task
R1440	T5459	T5456	dobj	test,performed
R1441	T5460	T5459	compound	probe,test
R1442	T5461	T5459	punct	", ",test
R1443	T5462	T5463	prep	in,removed
R1444	T5463	T5459	relcl	removed,test
R1445	T5464	T5462	pobj	which,in
R1446	T5465	T5466	det	the,platform
R1447	T5466	T5463	nsubjpass	platform,removed
R1448	T5467	T5463	auxpass	was,removed
R1449	T5468	T5463	prep	from,removed
R145	T727	T726	compound	water,maze
R1450	T5469	T5470	det	the,pool
R1451	T5470	T5468	pobj	pool,from
R1452	T5471	T5463	prep	after,removed
R1453	T5472	T5471	pobj	completion,after
R1454	T5473	T5472	prep	of,completion
R1455	T5474	T5475	det	the,task
R1456	T5475	T5473	pobj	task,of
R1457	T5476	T5477	amod	hidden,platform
R1458	T5477	T5475	compound	platform,task
R1459	T5478	T5456	punct	", ",performed
R146	T728	T724	compound	task,results
R1460	T5479	T5456	cc	and,performed
R1461	T5480	T5481	det	the,mice
R1462	T5481	T5483	nsubjpass	mice,allowed
R1463	T5482	T5481	amod	trained,mice
R1464	T5483	T5456	conj	allowed,performed
R1465	T5484	T5483	auxpass	were,allowed
R1466	T5485	T5486	aux	to,swim
R1467	T5486	T5483	xcomp	swim,allowed
R1468	T5487	T5486	advmod	freely,swim
R1469	T5488	T5486	prep	for,swim
R147	T729	T722	acomp	normal,are
R1470	T5489	T5490	nummod	60,sec
R1471	T5490	T5488	pobj	sec,for
R1472	T5491	T5483	punct	.,allowed
R1473	T5493	T5494	det	The,time
R1474	T5494	T5495	nsubj	time,is
R1475	T5496	T5494	acl	spent,time
R1476	T5497	T5496	prep	in,spent
R1477	T5498	T5499	det	the,quadrant
R1478	T5499	T5497	pobj	quadrant,in
R1479	T5500	T5499	compound	target,quadrant
R148	T730	T720	punct	", ",showed
R1480	T5501	T5494	prep	of,time
R1481	T5502	T5501	punct	(,of
R1482	T5503	T5504	punct	-,-
R1483	T5504	T5501	punct	-,of
R1484	T5505	T5504	punct	/,-
R1485	T5506	T5495	punct	),is
R1486	T5507	T5508	advmod	significantly,lower
R1487	T5508	T5495	acomp	lower,is
R1488	T5509	T5508	prep	than,lower
R1489	T5510	T5509	pobj	that,than
R149	T731	T720	cc	but,showed
R1490	T5511	T5510	prep	of,that
R1491	T5512	T5513	punct	(,mice
R1492	T5513	T5511	pobj	mice,of
R1493	T5514	T5515	punct	+,+
R1494	T5515	T5513	punct	+,mice
R1495	T5516	T5515	punct	/,+
R1496	T5517	T5513	punct	),mice
R1497	T5518	T5519	punct	(,2B
R1498	T5519	T5495	parataxis	2B,is
R1499	T5520	T5519	compound	Fig.,2B
R15	T585	T583	attr	member,is
R150	T732	T733	det	the,skills
R1500	T5521	T5519	punct	),2B
R1501	T5522	T5495	punct	.,is
R1502	T5524	T5525	nmod	Adam11,mice
R1503	T5525	T5531	nsubj	mice,appeared
R1504	T5526	T5524	punct	(,Adam11
R1505	T5527	T5524	punct	+,Adam11
R1506	T5528	T5524	punct	/,Adam11
R1507	T5529	T5524	punct	-,Adam11
R1508	T5530	T5525	punct	),mice
R1509	T5532	T5533	aux	to,spend
R151	T733	T741	nsubj	skills,are
R1510	T5533	T5531	xcomp	spend,appeared
R1511	T5534	T5535	det	a,time
R1512	T5535	T5533	dobj	time,spend
R1513	T5536	T5535	amod	shorter,time
R1514	T5537	T5533	prep	in,spend
R1515	T5538	T5539	det	the,quadrant
R1516	T5539	T5537	pobj	quadrant,in
R1517	T5540	T5539	compound	target,quadrant
R1518	T5541	T5531	punct	", ",appeared
R1519	T5542	T5531	cc	but,appeared
R152	T734	T735	amod	hidden,maze
R1520	T5543	T5544	expl	there,was
R1521	T5544	T5531	conj	was,appeared
R1522	T5545	T5546	det	no,difference
R1523	T5546	T5544	attr	difference,was
R1524	T5547	T5546	amod	significant,difference
R1525	T5548	T5546	prep	between,difference
R1526	T5549	T5548	punct	(,between
R1527	T5550	T5551	punct	+,+
R1528	T5551	T5553	punct	+,mice
R1529	T5552	T5551	punct	/,+
R153	T735	T737	nmod	maze,task
R1530	T5553	T5548	pobj	mice,between
R1531	T5554	T5551	punct	),+
R1532	T5555	T5551	cc	and,+
R1533	T5556	T5557	punct	(,-
R1534	T5557	T5551	conj	-,+
R1535	T5558	T5557	punct	+,-
R1536	T5559	T5557	punct	/,-
R1537	T5560	T5553	punct	),mice
R1538	T5561	T5562	punct	(,2B
R1539	T5562	T5544	parataxis	2B,was
R154	T736	T735	nmod	water,maze
R1540	T5563	T5562	compound	Fig.,2B
R1541	T5564	T5562	punct	),2B
R1542	T5565	T5544	punct	.,was
R1543	T5567	T5568	det	These,results
R1544	T5568	T5569	nsubj	results,indicate
R1545	T5570	T5571	det	a,impairment
R1546	T5571	T5569	dobj	impairment,indicate
R1547	T5572	T5573	amod	spatial,learning
R1548	T5573	T5571	compound	learning,impairment
R1549	T5574	T5569	prep	in,indicate
R155	T737	T733	compound	task,skills
R1550	T5575	T5576	punct	(,mice
R1551	T5576	T5574	pobj	mice,in
R1552	T5577	T5578	punct	-,-
R1553	T5578	T5576	punct	-,mice
R1554	T5579	T5578	punct	/,-
R1555	T5580	T5576	punct	),mice
R1556	T5581	T5569	punct	.,indicate
R1557	T5583	T5584	det	The,distance
R1558	T5584	T5586	nsubj	distance,was
R1559	T5585	T5584	compound	swimming,distance
R156	T738	T735	cc	and,maze
R1560	T5587	T5584	prep	of,distance
R1561	T5588	T5589	punct	(,mice
R1562	T5589	T5587	pobj	mice,of
R1563	T5590	T5591	punct	+,+
R1564	T5591	T5589	punct	+,mice
R1565	T5592	T5591	punct	/,+
R1566	T5593	T5591	punct	),+
R1567	T5594	T5591	punct	", ",+
R1568	T5595	T5596	punct	(,-
R1569	T5596	T5591	conj	-,+
R157	T739	T740	amod	rotating,rod
R1570	T5597	T5596	punct	+,-
R1571	T5598	T5596	punct	/,-
R1572	T5599	T5596	punct	),-
R1573	T5600	T5596	cc	and,-
R1574	T5601	T5602	punct	(,-
R1575	T5602	T5596	conj	-,-
R1576	T5603	T5602	punct	-,-
R1577	T5604	T5602	punct	/,-
R1578	T5605	T5589	punct	),mice
R1579	T5606	T5586	punct	", ",was
R158	T740	T735	conj	rod,maze
R1580	T5607	T5586	advmod	however,was
R1581	T5608	T5586	punct	", ",was
R1582	T5609	T5586	acomp	similar,was
R1583	T5610	T5586	prep	during,was
R1584	T5611	T5612	det	the,trial
R1585	T5612	T5610	pobj	trial,during
R1586	T5613	T5612	compound	probe,trial
R1587	T5614	T5615	punct	(,2C
R1588	T5615	T5586	parataxis	2C,was
R1589	T5616	T5615	compound	Fig.,2C
R159	T741	T720	conj	are,showed
R1590	T5617	T5615	punct	),2C
R1591	T5618	T5586	punct	.,was
R1592	T5620	T5621	prep	In,improved
R1593	T5622	T5623	det	the,task
R1594	T5623	T5620	pobj	task,In
R1595	T5624	T5625	amod	visible,platform
R1596	T5625	T5623	compound	platform,task
R1597	T5626	T5621	punct	", ",improved
R1598	T5627	T5628	det	the,performance
R1599	T5628	T5621	nsubj	performance,improved
R16	T586	T585	prep	of,member
R160	T742	T741	acomp	impaired,are
R1600	T5629	T5628	prep	of,performance
R1601	T5630	T5629	pobj	mice,of
R1602	T5631	T5630	prep	with,mice
R1603	T5632	T5633	punct	(,genotypes
R1604	T5633	T5631	pobj	genotypes,with
R1605	T5634	T5635	punct	+,+
R1606	T5635	T5633	punct	+,genotypes
R1607	T5636	T5635	punct	/,+
R1608	T5637	T5635	punct	),+
R1609	T5638	T5635	punct	", ",+
R161	T743	T741	prep	in,are
R1610	T5639	T5640	punct	(,-
R1611	T5640	T5635	conj	-,+
R1612	T5641	T5640	punct	+,-
R1613	T5642	T5640	punct	/,-
R1614	T5643	T5640	punct	),-
R1615	T5644	T5640	cc	and,-
R1616	T5645	T5646	punct	(,-
R1617	T5646	T5640	conj	-,-
R1618	T5647	T5646	punct	-,-
R1619	T5648	T5646	punct	/,-
R162	T744	T745	npadvmod	ADAM11,deficient
R1620	T5649	T5633	punct	),genotypes
R1621	T5650	T5621	prep	during,improved
R1622	T5651	T5652	det	the,course
R1623	T5652	T5650	pobj	course,during
R1624	T5653	T5652	prep	of,course
R1625	T5654	T5655	det	the,sessions
R1626	T5655	T5653	pobj	sessions,of
R1627	T5656	T5655	compound	test,sessions
R1628	T5657	T5621	punct	", ",improved
R1629	T5658	T5659	mark	as,indicated
R163	T745	T747	amod	deficient,mice
R1630	T5659	T5621	advcl	indicated,improved
R1631	T5660	T5659	agent	by,indicated
R1632	T5661	T5662	det	a,decrease
R1633	T5662	T5660	pobj	decrease,by
R1634	T5663	T5662	amod	progressive,decrease
R1635	T5664	T5662	prep	in,decrease
R1636	T5665	T5666	det	the,latency
R1637	T5666	T5664	pobj	latency,in
R1638	T5667	T5666	prep	for,latency
R1639	T5668	T5667	pcomp	locating,for
R164	T746	T745	punct	-,deficient
R1640	T5669	T5670	det	the,platform
R1641	T5670	T5668	dobj	platform,locating
R1642	T5671	T5672	punct	(,2D
R1643	T5672	T5659	parataxis	2D,indicated
R1644	T5673	T5672	compound	Fig.,2D
R1645	T5674	T5672	punct	),2D
R1646	T5675	T5621	punct	", ",improved
R1647	T5676	T5621	advcl	suggesting,improved
R1648	T5677	T5678	mark	that,learn
R1649	T5678	T5676	ccomp	learn,suggesting
R165	T747	T743	pobj	mice,in
R1650	T5679	T5680	punct	(,mice
R1651	T5680	T5678	nsubj	mice,learn
R1652	T5681	T5682	punct	-,-
R1653	T5682	T5680	punct	-,mice
R1654	T5683	T5682	punct	/,-
R1655	T5684	T5680	punct	),mice
R1656	T5685	T5686	det	this,task
R1657	T5686	T5678	dobj	task,learn
R1658	T5687	T5688	amod	visible,platform
R1659	T5688	T5686	compound	platform,task
R166	T748	T741	punct	.,are
R1660	T5689	T5690	advmod	just,well
R1661	T5690	T5678	advmod	well,learn
R1662	T5691	T5690	advmod	as,well
R1663	T5692	T5690	prep	as,well
R1664	T5693	T5694	punct	(,mice
R1665	T5694	T5692	pobj	mice,as
R1666	T5695	T5696	punct	+,+
R1667	T5696	T5694	punct	+,mice
R1668	T5697	T5696	punct	/,+
R1669	T5698	T5696	punct	),+
R167	T752	T753	poss	Our,results
R1670	T5699	T5696	cc	and,+
R1671	T5700	T5701	punct	(,-
R1672	T5701	T5696	conj	-,+
R1673	T5702	T5701	punct	+,-
R1674	T5703	T5701	punct	/,-
R1675	T5704	T5694	punct	),mice
R1676	T5705	T5621	punct	.,improved
R1677	T5707	T5708	det	These,results
R1678	T5708	T5709	nsubj	results,indicated
R1679	T5710	T5709	advmod	also,indicated
R168	T753	T754	nsubj	results,indicate
R1680	T5711	T5712	mark	that,have
R1681	T5712	T5709	ccomp	have,indicated
R1682	T5713	T5714	punct	(,mice
R1683	T5714	T5712	nsubj	mice,have
R1684	T5715	T5716	punct	-,-
R1685	T5716	T5714	punct	-,mice
R1686	T5717	T5716	punct	/,-
R1687	T5718	T5714	punct	),mice
R1688	T5719	T5720	amod	normal,function
R1689	T5720	T5712	dobj	function,have
R169	T755	T756	mark	that,affect
R1690	T5721	T5720	amod	visible,function
R1691	T5722	T5721	cc	and,visible
R1692	T5723	T5721	conj	motor,visible
R1693	T5724	T5720	cc	and,function
R1694	T5725	T5726	det	the,motivation
R1695	T5726	T5720	conj	motivation,function
R1696	T5727	T5726	acl	needed,motivation
R1697	T5728	T5727	prep	in,needed
R1698	T5729	T5730	det	the,task
R1699	T5730	T5728	pobj	task,in
R17	T587	T588	det	the,family
R170	T756	T754	ccomp	affect,indicate
R1700	T5731	T5732	compound	water,maze
R1701	T5732	T5730	compound	maze,task
R1702	T5733	T5709	punct	.,indicated
R1703	T6623	T6624	compound	Motor,function
R1704	T6625	T6624	prep	of,function
R1705	T6626	T6627	npadvmod	ADAM11,deficient
R1706	T6627	T6629	amod	deficient,mice
R1707	T6628	T6627	punct	-,deficient
R1708	T6629	T6625	pobj	mice,of
R1709	T6631	T6632	aux	To,study
R171	T757	T758	compound	ADAM11,mutation
R1710	T6632	T6633	advcl	study,examined
R1711	T6634	T6635	det	the,functions
R1712	T6635	T6632	dobj	functions,study
R1713	T6636	T6635	prep	of,functions
R1714	T6637	T6636	pobj	ADAM11,of
R1715	T6638	T6632	prep	in,study
R1716	T6639	T6640	det	the,cerebellum
R1717	T6640	T6638	pobj	cerebellum,in
R1718	T6641	T6633	punct	", ",examined
R1719	T6642	T6633	nsubj	we,examined
R172	T758	T756	nsubj	mutation,affect
R1720	T6643	T6644	det	the,function
R1721	T6644	T6633	dobj	function,examined
R1722	T6645	T6644	amod	motor,function
R1723	T6646	T6644	prep	of,function
R1724	T6647	T6648	npadvmod	ADAM11,deficient
R1725	T6648	T6650	amod	deficient,mice
R1726	T6649	T6648	punct	-,deficient
R1727	T6650	T6646	pobj	mice,of
R1728	T6651	T6633	advcl	using,examined
R1729	T6652	T6653	det	a,task
R173	T759	T756	aux	does,affect
R1730	T6653	T6651	dobj	task,using
R1731	T6654	T6655	amod	rotating,rod
R1732	T6655	T6653	compound	rod,task
R1733	T6656	T6657	punct	[,28
R1734	T6657	T6633	parataxis	28,examined
R1735	T6658	T6657	punct	],28
R1736	T6659	T6633	punct	.,examined
R1737	T6661	T6662	prep	In,was
R1738	T6663	T6664	det	the,test
R1739	T6664	T6661	pobj	test,In
R174	T760	T756	neg	not,affect
R1740	T6665	T6666	amod	rotating,rod
R1741	T6666	T6664	compound	rod,test
R1742	T6667	T6662	punct	", ",was
R1743	T6668	T6669	det	the,time
R1744	T6669	T6662	nsubj	time,was
R1745	T6670	T6669	compound	retention,time
R1746	T6671	T6669	prep	of,time
R1747	T6672	T6673	punct	(,mice
R1748	T6673	T6671	pobj	mice,of
R1749	T6674	T6675	punct	+,-
R175	T761	T762	compound	cell,migration
R1750	T6675	T6673	punct	-,mice
R1751	T6676	T6675	punct	/,-
R1752	T6677	T6675	punct	),-
R1753	T6678	T6675	cc	and,-
R1754	T6679	T6680	punct	(,-
R1755	T6680	T6675	conj	-,-
R1756	T6681	T6680	punct	-,-
R1757	T6682	T6680	punct	/,-
R1758	T6683	T6673	punct	),mice
R1759	T6684	T6673	prep	on,mice
R176	T762	T756	dobj	migration,affect
R1760	T6685	T6686	det	the,rod
R1761	T6686	T6684	pobj	rod,on
R1762	T6687	T6662	neg	not,was
R1763	T6688	T6689	advmod	significantly,different
R1764	T6689	T6662	acomp	different,was
R1765	T6690	T6689	prep	from,different
R1766	T6691	T6690	pobj	that,from
R1767	T6692	T6691	prep	of,that
R1768	T6693	T6694	punct	(,mice
R1769	T6694	T6692	pobj	mice,of
R177	T763	T762	cc	and,migration
R1770	T6695	T6696	punct	+,+
R1771	T6696	T6694	punct	+,mice
R1772	T6697	T6696	punct	/,+
R1773	T6698	T6694	punct	),mice
R1774	T6699	T6662	prep	at,was
R1775	T6700	T6701	nummod	0,rpm
R1776	T6701	T6699	pobj	rpm,at
R1777	T6702	T6703	punct	(,stationary
R1778	T6703	T6701	parataxis	stationary,rpm
R1779	T6704	T6703	punct	),stationary
R178	T764	T762	conj	differentiation,migration
R1780	T6705	T6706	punct	[,0.96
R1781	T6706	T6662	parataxis	0.96,was
R1782	T6707	T6708	punct	+,-
R1783	T6708	T6710	punct	-,0.21
R1784	T6709	T6708	punct	/,-
R1785	T6710	T6706	dep	0.21,0.96
R1786	T6711	T6710	punct	: ,0.21
R1787	T6712	T6713	nsubj	F,1.67
R1788	T6713	T6710	ccomp	1.67,0.21
R1789	T6714	T6712	punct	(,F
R179	T765	T756	prep	during,affect
R1790	T6715	T6712	nummod	1,F
R1791	T6716	T6712	punct	", ",F
R1792	T6717	T6712	nummod	80,F
R1793	T6718	T6712	punct	),F
R1794	T6719	T6713	punct	=,1.67
R1795	T6720	T6710	punct	", ",0.21
R1796	T6721	T6710	nsubj	p,0.21
R1797	T6722	T6710	punct	=,0.21
R1798	T6723	T6706	punct	;,0.96
R1799	T6724	T6725	punct	-,-
R18	T588	T586	pobj	family,of
R180	T766	T765	pobj	development,during
R1800	T6725	T6706	punct	-,0.96
R1801	T6726	T6725	punct	/,-
R1802	T6727	T6706	punct	: ,0.96
R1803	T6728	T6729	nsubj	F,0.002
R1804	T6729	T6706	ccomp	0.002,0.96
R1805	T6730	T6728	punct	(,F
R1806	T6731	T6728	nummod	1,F
R1807	T6732	T6728	punct	", ",F
R1808	T6733	T6728	nummod	88,F
R1809	T6734	T6728	punct	),F
R181	T767	T756	punct	", ",affect
R1810	T6735	T6729	punct	=,0.002
R1811	T6736	T6706	punct	", ",0.96
R1812	T6737	T6706	nsubj	p,0.96
R1813	T6738	T6706	punct	=,0.96
R1814	T6739	T6706	punct	],0.96
R1815	T6740	T6741	punct	(,3A
R1816	T6741	T6662	parataxis	3A,was
R1817	T6742	T6741	compound	Fig.,3A
R1818	T6743	T6741	punct	),3A
R1819	T6744	T6662	punct	.,was
R182	T768	T756	cc	but,affect
R1820	T6746	T6747	prep	In,seen
R1821	T6748	T6749	punct	(,mice
R1822	T6749	T6746	pobj	mice,In
R1823	T6750	T6751	punct	+,-
R1824	T6751	T6749	punct	-,mice
R1825	T6752	T6751	punct	/,-
R1826	T6753	T6749	punct	),mice
R1827	T6754	T6747	punct	", ",seen
R1828	T6755	T6756	det	the,tendency
R1829	T6756	T6747	nsubjpass	tendency,seen
R183	T769	T756	conj	affects,affect
R1830	T6757	T6756	prep	of,tendency
R1831	T6758	T6759	amod	decreased,times
R1832	T6759	T6757	pobj	times,of
R1833	T6760	T6759	compound	retention,times
R1834	T6761	T6747	auxpass	was,seen
R1835	T6762	T6747	prep	at,seen
R1836	T6763	T6764	nummod	5,rpm
R1837	T6764	T6762	pobj	rpm,at
R1838	T6765	T6763	punct	", ",5
R1839	T6766	T6763	conj	10,5
R184	T770	T769	dobj	learning,affects
R1840	T6767	T6766	cc	and,10
R1841	T6768	T6766	conj	15,10
R1842	T6769	T6747	punct	", ",seen
R1843	T6770	T6747	cc	but,seen
R1844	T6771	T6772	expl	there,was
R1845	T6772	T6747	conj	was,seen
R1846	T6773	T6774	det	no,difference
R1847	T6774	T6772	attr	difference,was
R1848	T6775	T6774	amod	significant,difference
R1849	T6776	T6774	prep	between,difference
R185	T771	T770	cc	and,learning
R1850	T6777	T6778	punct	(,mice
R1851	T6778	T6776	pobj	mice,between
R1852	T6779	T6780	punct	+,+
R1853	T6780	T6778	punct	+,mice
R1854	T6781	T6780	punct	/,+
R1855	T6782	T6780	punct	),+
R1856	T6783	T6780	cc	and,+
R1857	T6784	T6785	punct	(,-
R1858	T6785	T6780	conj	-,+
R1859	T6786	T6785	punct	+,-
R186	T772	T773	compound	motor,coordination
R1860	T6787	T6785	punct	/,-
R1861	T6788	T6778	punct	),mice
R1862	T6789	T6790	punct	[,0.11
R1863	T6790	T6772	parataxis	0.11,was
R1864	T6791	T6792	nummod	5,rpm
R1865	T6792	T6793	dep	rpm,0.27
R1866	T6793	T6790	dep	0.27,0.11
R1867	T6794	T6793	punct	: ,0.27
R1868	T6795	T6796	nsubj	F,1.27
R1869	T6796	T6793	ccomp	1.27,0.27
R187	T773	T770	conj	coordination,learning
R1870	T6797	T6795	punct	(,F
R1871	T6798	T6795	nummod	1,F
R1872	T6799	T6795	punct	", ",F
R1873	T6800	T6795	nummod	20,F
R1874	T6801	T6795	punct	),F
R1875	T6802	T6796	punct	=,1.27
R1876	T6803	T6793	punct	", ",0.27
R1877	T6804	T6793	nsubj	p,0.27
R1878	T6805	T6793	punct	=,0.27
R1879	T6806	T6790	punct	;,0.11
R188	T774	T754	punct	.,indicate
R1880	T6807	T6808	nummod	10,rpm
R1881	T6808	T6809	dep	rpm,0.31
R1882	T6809	T6790	dep	0.31,0.11
R1883	T6810	T6809	punct	: ,0.31
R1884	T6811	T6812	nsubj	F,1.07
R1885	T6812	T6809	ccomp	1.07,0.31
R1886	T6813	T6811	punct	(,F
R1887	T6814	T6811	nummod	1,F
R1888	T6815	T6811	punct	", ",F
R1889	T6816	T6811	nummod	20,F
R189	T776	T777	advmod	Thus,play
R1890	T6817	T6811	punct	),F
R1891	T6818	T6812	punct	=,1.07
R1892	T6819	T6809	punct	", ",0.31
R1893	T6820	T6809	nsubj	p,0.31
R1894	T6821	T6809	punct	=,0.31
R1895	T6822	T6790	punct	;,0.11
R1896	T6823	T6824	nummod	15,rpm
R1897	T6824	T6790	dep	rpm,0.11
R1898	T6825	T6790	punct	: ,0.11
R1899	T6826	T6827	nsubj	F,2.716
R19	T589	T588	compound	ADAM,family
R190	T778	T777	punct	", ",play
R1900	T6827	T6790	ccomp	2.716,0.11
R1901	T6828	T6826	punct	(,F
R1902	T6829	T6826	nummod	1,F
R1903	T6830	T6826	punct	", ",F
R1904	T6831	T6826	nummod	20,F
R1905	T6832	T6827	punct	),2.716
R1906	T6833	T6827	punct	=,2.716
R1907	T6834	T6790	punct	", ",0.11
R1908	T6835	T6790	nsubj	p,0.11
R1909	T6836	T6790	punct	=,0.11
R191	T779	T777	nsubj	ADAM11,play
R1910	T6837	T6790	punct	],0.11
R1911	T6838	T6839	punct	(,3B
R1912	T6839	T6772	parataxis	3B,was
R1913	T6840	T6839	compound	Figs.,3B
R1914	T6841	T6839	punct	", ",3B
R1915	T6842	T6839	conj	3C,3B
R1916	T6843	T6842	cc	and,3C
R1917	T6844	T6842	conj	3D,3C
R1918	T6845	T6839	punct	),3B
R1919	T6846	T6772	punct	.,was
R192	T780	T777	aux	might,play
R1920	T6848	T6849	advmod	However,fell
R1921	T6850	T6849	punct	", ",fell
R1922	T6851	T6852	punct	(,mice
R1923	T6852	T6849	nsubj	mice,fell
R1924	T6853	T6854	punct	-,-
R1925	T6854	T6852	punct	-,mice
R1926	T6855	T6854	punct	/,-
R1927	T6856	T6852	punct	),mice
R1928	T6857	T6858	advmod	more,quickly
R1929	T6858	T6849	advmod	quickly,fell
R193	T781	T782	det	an,role
R1930	T6859	T6849	prep	from,fell
R1931	T6860	T6861	det	the,rod
R1932	T6861	T6859	pobj	rod,from
R1933	T6862	T6849	prep	than,fell
R1934	T6863	T6862	punct	(,than
R1935	T6864	T6865	punct	+,+
R1936	T6865	T6867	punct	+,mice
R1937	T6866	T6865	punct	/,+
R1938	T6867	T6862	pobj	mice,than
R1939	T6868	T6867	punct	),mice
R194	T782	T777	dobj	role,play
R1940	T6869	T6849	prep	at,fell
R1941	T6870	T6871	nummod	5,rpm
R1942	T6871	T6869	pobj	rpm,at
R1943	T6872	T6870	punct	", ",5
R1944	T6873	T6870	conj	10,5
R1945	T6874	T6873	cc	and,10
R1946	T6875	T6873	conj	15,10
R1947	T6876	T6877	punct	[,0.0002
R1948	T6877	T6849	parataxis	0.0002,fell
R1949	T6878	T6879	nummod	5,rpm
R195	T783	T782	amod	important,role
R1950	T6879	T6880	dep	rpm,0.0002
R1951	T6880	T6877	dep	0.0002,0.0002
R1952	T6881	T6880	punct	: ,0.0002
R1953	T6882	T6883	nsubj	F,17.51
R1954	T6883	T6880	ccomp	17.51,0.0002
R1955	T6884	T6882	punct	(,F
R1956	T6885	T6882	nummod	1,F
R1957	T6886	T6882	punct	", ",F
R1958	T6887	T6882	nummod	27.3,F
R1959	T6888	T6883	punct	),17.51
R196	T784	T782	nmod	signalling,role
R1960	T6889	T6883	punct	=,17.51
R1961	T6890	T6880	punct	", ",0.0002
R1962	T6891	T6880	nsubj	p,0.0002
R1963	T6892	T6880	punct	=,0.0002
R1964	T6893	T6877	punct	;,0.0002
R1965	T6894	T6895	nummod	10,rpm
R1966	T6895	T6896	dep	rpm,0.003
R1967	T6896	T6877	dep	0.003,0.0002
R1968	T6897	T6896	punct	: ,0.003
R1969	T6898	T6899	nsubj	F,11.05
R197	T785	T784	cc	or,signalling
R1970	T6899	T6896	ccomp	11.05,0.003
R1971	T6900	T6898	punct	(,F
R1972	T6901	T6898	nummod	1,F
R1973	T6902	T6898	punct	", ",F
R1974	T6903	T6898	nummod	22,F
R1975	T6904	T6899	punct	),11.05
R1976	T6905	T6899	punct	=,11.05
R1977	T6906	T6896	punct	", ",0.003
R1978	T6907	T6896	nsubj	p,0.003
R1979	T6908	T6896	punct	=,0.003
R198	T786	T784	conj	structural,signalling
R1980	T6909	T6877	punct	;,0.0002
R1981	T6910	T6911	nummod	15,rpm
R1982	T6911	T6877	dep	rpm,0.0002
R1983	T6912	T6877	punct	: ,0.0002
R1984	T6913	T6914	nsubj	F,19.22
R1985	T6914	T6877	ccomp	19.22,0.0002
R1986	T6915	T6913	punct	(,F
R1987	T6916	T6913	nummod	1,F
R1988	T6917	T6913	punct	", ",F
R1989	T6918	T6913	nummod	22,F
R199	T787	T782	prep	as,role
R1990	T6919	T6913	punct	),F
R1991	T6920	T6914	punct	=,19.22
R1992	T6921	T6877	punct	", ",0.0002
R1993	T6922	T6877	nsubj	p,0.0002
R1994	T6923	T6877	punct	=,0.0002
R1995	T6924	T6877	punct	],0.0002
R1996	T6925	T6926	punct	(,3B
R1997	T6926	T6849	parataxis	3B,fell
R1998	T6927	T6926	compound	Figs.,3B
R1999	T6928	T6926	punct	", ",3B
R20	T590	T588	compound	gene,family
R200	T788	T789	det	a,molecule
R2000	T6929	T6926	conj	3C,3B
R2001	T6930	T6929	cc	and,3C
R2002	T6931	T6929	conj	3D,3C
R2003	T6932	T6926	punct	),3B
R2004	T6933	T6849	punct	.,fell
R2005	T6935	T6936	det	The,time
R2006	T6936	T6938	nsubjpass	time,improved
R2007	T6937	T6936	compound	retention,time
R2008	T6939	T6938	auxpass	was,improved
R2009	T6940	T6938	neg	not,improved
R201	T789	T787	pobj	molecule,as
R2010	T6941	T6938	advmod	significantly,improved
R2011	T6942	T6938	prep	in,improved
R2012	T6943	T6944	punct	(,mice
R2013	T6944	T6942	pobj	mice,in
R2014	T6945	T6946	punct	-,-
R2015	T6946	T6944	punct	-,mice
R2016	T6947	T6946	punct	/,-
R2017	T6948	T6944	punct	),mice
R2018	T6949	T6938	prep	across,improved
R2019	T6950	T6949	pobj	trials,across
R202	T790	T791	compound	cell,adhesion
R2020	T6951	T6950	prep	of,trials
R2021	T6952	T6951	pobj	training,of
R2022	T6953	T6950	prep	at,trials
R2023	T6954	T6955	nummod	5,rpm
R2024	T6955	T6953	pobj	rpm,at
R2025	T6956	T6954	punct	", ",5
R2026	T6957	T6954	conj	10,5
R2027	T6958	T6957	cc	and,10
R2028	T6959	T6957	conj	15,10
R2029	T6960	T6961	punct	[,0.14
R203	T791	T789	compound	adhesion,molecule
R2030	T6961	T6938	parataxis	0.14,improved
R2031	T6962	T6963	nummod	5,rpm
R2032	T6963	T6964	dep	rpm,0.15
R2033	T6964	T6961	dep	0.15,0.14
R2034	T6965	T6964	punct	: ,0.15
R2035	T6966	T6967	nsubj	F,2.05
R2036	T6967	T6964	ccomp	2.05,0.15
R2037	T6968	T6966	punct	(,F
R2038	T6969	T6966	nummod	3,F
R2039	T6970	T6966	punct	", ",F
R204	T792	T782	prep	at,role
R2040	T6971	T6966	nummod	15.3,F
R2041	T6972	T6966	punct	),F
R2042	T6973	T6967	punct	=,2.05
R2043	T6974	T6964	punct	", ",0.15
R2044	T6975	T6964	nsubj	p,0.15
R2045	T6976	T6964	punct	=,0.15
R2046	T6977	T6961	punct	;,0.14
R2047	T6978	T6979	nummod	10,rpm
R2048	T6979	T6980	dep	rpm,0.07
R2049	T6980	T6961	dep	0.07,0.14
R205	T793	T794	det	the,synapse
R2050	T6981	T6980	punct	: ,0.07
R2051	T6982	T6983	nsubj	F,2.61
R2052	T6983	T6980	ccomp	2.61,0.07
R2053	T6984	T6982	punct	(,F
R2054	T6985	T6982	nummod	7,F
R2055	T6986	T6982	punct	", ",F
R2056	T6987	T6982	nummod	11,F
R2057	T6988	T6982	punct	),F
R2058	T6989	T6983	punct	=,2.61
R2059	T6990	T6980	punct	", ",0.07
R206	T794	T792	pobj	synapse,at
R2060	T6991	T6980	nsubj	p,0.07
R2061	T6992	T6980	punct	=,0.07
R2062	T6993	T6961	punct	;,0.14
R2063	T6994	T6995	nummod	15,rpm
R2064	T6995	T6961	dep	rpm,0.14
R2065	T6996	T6961	punct	: ,0.14
R2066	T6997	T6998	nsubj	F,1.57
R2067	T6998	T6961	ccomp	1.57,0.14
R2068	T6999	T6997	punct	(,F
R2069	T7000	T6997	nummod	19,F
R207	T795	T777	punct	", ",play
R2070	T7001	T6997	punct	", ",F
R2071	T7002	T6997	nummod	26.6,F
R2072	T7003	T6997	punct	),F
R2073	T7004	T6998	punct	=,1.57
R2074	T7005	T6961	punct	", ",0.14
R2075	T7006	T6961	nsubj	p,0.14
R2076	T7007	T6961	punct	=,0.14
R2077	T7008	T6961	punct	],0.14
R2078	T7009	T7010	punct	(,3B
R2079	T7010	T6938	parataxis	3B,improved
R208	T796	T777	cc	and,play
R2080	T7011	T7010	compound	Figs.,3B
R2081	T7012	T7010	punct	", ",3B
R2082	T7013	T7010	conj	3C,3B
R2083	T7014	T7013	cc	and,3C
R2084	T7015	T7013	conj	3D,3C
R2085	T7016	T7010	punct	),3B
R2086	T7017	T6938	punct	.,improved
R2087	T7019	T7020	prep	In,showed
R2088	T7021	T7022	det	a,test
R2089	T7022	T7019	pobj	test,In
R209	T797	T798	aux	may,participate
R2090	T7023	T7022	compound	traction,test
R2091	T7024	T7020	punct	", ",showed
R2092	T7025	T7026	punct	(,mice
R2093	T7026	T7020	nsubj	mice,showed
R2094	T7027	T7028	punct	-,-
R2095	T7028	T7026	punct	-,mice
R2096	T7029	T7028	punct	/,-
R2097	T7030	T7026	punct	),mice
R2098	T7031	T7032	det	a,strength
R2099	T7032	T7020	dobj	strength,showed
R21	T591	T583	cc	and,is
R210	T798	T777	conj	participate,play
R2100	T7033	T7032	amod	high,strength
R2101	T7034	T7032	compound	grip,strength
R2102	T7035	T7032	amod	similar,strength
R2103	T7036	T7035	prep	to,similar
R2104	T7037	T7036	pobj	that,to
R2105	T7038	T7037	prep	of,that
R2106	T7039	T7040	punct	(,mice
R2107	T7040	T7038	pobj	mice,of
R2108	T7041	T7042	punct	+,+
R2109	T7042	T7040	punct	+,mice
R211	T799	T798	advmod	thus,participate
R2110	T7043	T7042	punct	/,+
R2111	T7044	T7042	punct	),+
R2112	T7045	T7042	cc	and,+
R2113	T7046	T7047	punct	(,-
R2114	T7047	T7042	conj	-,+
R2115	T7048	T7047	punct	+,-
R2116	T7049	T7047	punct	/,-
R2117	T7050	T7040	punct	),mice
R2118	T7051	T7052	punct	(,Fig.
R2119	T7052	T7020	parataxis	Fig.,showed
R212	T800	T798	prep	in,participate
R2120	T7053	T7052	nummod	4,Fig.
R2121	T7054	T7052	punct	),Fig.
R2122	T7055	T7020	punct	.,showed
R2123	T7057	T7058	det	The,score
R2124	T7058	T7060	nsubj	score,were
R2125	T7059	T7058	amod	hanging,score
R2126	T7061	T7058	cc	and,score
R2127	T7062	T7058	conj	time,score
R2128	T7063	T7058	prep	of,score
R2129	T7064	T7065	punct	(,mice
R213	T801	T802	amod	synaptic,regulation
R2130	T7065	T7063	pobj	mice,of
R2131	T7066	T7067	punct	-,-
R2132	T7067	T7065	punct	-,mice
R2133	T7068	T7067	punct	/,-
R2134	T7069	T7065	punct	),mice
R2135	T7070	T7060	advmod	also,were
R2136	T7071	T7060	acomp	similar,were
R2137	T7072	T7071	prep	to,similar
R2138	T7073	T7072	pobj	those,to
R2139	T7074	T7073	prep	of,those
R214	T802	T800	pobj	regulation,in
R2140	T7075	T7076	punct	(,mice
R2141	T7076	T7074	pobj	mice,of
R2142	T7077	T7078	punct	+,+
R2143	T7078	T7076	punct	+,mice
R2144	T7079	T7078	punct	/,+
R2145	T7080	T7078	punct	),+
R2146	T7081	T7078	cc	and,+
R2147	T7082	T7083	punct	(,-
R2148	T7083	T7078	conj	-,+
R2149	T7084	T7083	punct	+,-
R215	T803	T802	acl	underlying,regulation
R2150	T7085	T7083	punct	/,-
R2151	T7086	T7076	punct	),mice
R2152	T7087	T7088	punct	(,5A
R2153	T7088	T7060	parataxis	5A,were
R2154	T7089	T7088	compound	Figs.,5A
R2155	T7090	T7088	cc	and,5A
R2156	T7091	T7088	conj	5B,5A
R2157	T7092	T7088	punct	),5A
R2158	T7093	T7060	punct	.,were
R2159	T7095	T7096	det	A,test
R216	T804	T805	amod	behavioural,changes
R2160	T7096	T7098	nsubj	test,reveal
R2161	T7097	T7096	compound	footprint,test
R2162	T7099	T7098	aux	did,reveal
R2163	T7100	T7098	neg	not,reveal
R2164	T7101	T7102	det	any,abnormalities
R2165	T7102	T7098	dobj	abnormalities,reveal
R2166	T7103	T7102	prep	in,abnormalities
R2167	T7104	T7105	amod	walking,patterns
R2168	T7105	T7103	pobj	patterns,in
R2169	T7106	T7102	punct	", ",abnormalities
R217	T805	T803	dobj	changes,underlying
R2170	T7107	T7102	prep	including,abnormalities
R2171	T7108	T7109	compound	stride,length
R2172	T7109	T7107	pobj	length,including
R2173	T7110	T7109	cc	and,length
R2174	T7111	T7112	compound	step,width
R2175	T7112	T7109	conj	width,length
R2176	T7113	T7098	punct	", ",reveal
R2177	T7114	T7098	prep	as,reveal
R2178	T7115	T7116	det	a,function
R2179	T7116	T7114	pobj	function,as
R218	T806	T777	punct	.,play
R2180	T7117	T7116	prep	of,function
R2181	T7118	T7117	pobj	genotypes,of
R2182	T7119	T7120	punct	(,6A
R2183	T7120	T7098	parataxis	6A,reveal
R2184	T7121	T7120	compound	Figs.,6A
R2185	T7122	T7120	cc	and,6A
R2186	T7123	T7120	conj	6B,6A
R2187	T7124	T7120	punct	),6A
R2188	T7125	T7098	punct	.,reveal
R219	T572	T569	conj	coordination,learning
R2199	T9981	T9982	prep	In,examined
R22	T592	T593	auxpass	is,expressed
R2200	T9983	T9984	det	the,study
R2201	T9984	T9981	pobj	study,In
R2202	T9985	T9984	amod	present,study
R2203	T9986	T9982	punct	", ",examined
R2204	T9987	T9982	nsubj	we,examined
R2205	T9988	T9989	det	the,function
R2206	T9989	T9982	dobj	function,examined
R2207	T9990	T9989	prep	of,function
R2208	T9991	T9990	pobj	ADAM11,of
R2209	T9992	T9982	prep	by,examined
R2210	T9993	T9992	pcomp	generating,by
R2211	T9994	T9993	dobj	mice,generating
R2212	T9995	T9996	dep	that,lacked
R2213	T9996	T9994	relcl	lacked,mice
R2214	T9997	T9998	det	the,gene
R2215	T9998	T9996	dobj	gene,lacked
R2216	T9999	T9998	compound	Adam11,gene
R2217	T10000	T9982	punct	.,examined
R2218	T10002	T10003	nsubjpass	It,reported
R2219	T10004	T10003	aux	has,reported
R222	T2208	T2209	det	The,family
R2220	T10005	T10003	auxpass	been,reported
R2221	T10006	T10007	mark	that,expressed
R2222	T10007	T10003	ccomp	expressed,reported
R2223	T10008	T10009	det	the,gene
R2224	T10009	T10007	nsubjpass	gene,expressed
R2225	T10010	T10009	compound	Adam11,gene
R2226	T10011	T10007	auxpass	is,expressed
R2227	T10012	T10007	prep	in,expressed
R2228	T10013	T10014	det	the,brain
R2229	T10014	T10012	pobj	brain,in
R223	T2209	T2217	nsubj	family,comprises
R2230	T10015	T10014	punct	", ",brain
R2231	T10016	T10014	conj	heart,brain
R2232	T10017	T10016	punct	", ",heart
R2233	T10018	T10016	conj	liver,heart
R2234	T10019	T10018	cc	and,liver
R2235	T10020	T10018	conj	testis,liver
R2236	T10021	T10007	punct	", ",expressed
R2237	T10022	T10023	mark	as,manifested
R2238	T10023	T10007	advcl	manifested,expressed
R2239	T10024	T10023	prep	in,manifested
R224	T2210	T2209	nmod	ADAM,family
R2240	T10025	T10026	compound	Northern,blot
R2241	T10026	T10027	compound	blot,analysis
R2242	T10027	T10024	pobj	analysis,in
R2243	T10028	T10029	punct	[,19
R2244	T10029	T10003	parataxis	19,reported
R2245	T10030	T10029	punct	],19
R2246	T10031	T10003	punct	.,reported
R2247	T10033	T10034	advmod	Interestingly,appeared
R2248	T10035	T10034	punct	", ",appeared
R2249	T10036	T10037	npadvmod	ADAM11,deficient
R225	T2211	T2210	punct	(,ADAM
R2250	T10037	T10039	amod	deficient,mice
R2251	T10038	T10037	punct	-,deficient
R2252	T10039	T10034	nsubj	mice,appeared
R2253	T10040	T10034	oprd	normal,appeared
R2254	T10041	T10034	cc	and,appeared
R2255	T10042	T10034	conj	survived,appeared
R2256	T10043	T10044	amod	more,one
R2257	T10044	T10046	nummod	one,year
R2258	T10045	T10044	quantmod	than,one
R2259	T10046	T10042	npadvmod	year,survived
R226	T2212	T2213	det	A,Disintegrin
R2260	T10047	T10042	prep	without,survived
R2261	T10048	T10049	amod	apparent,abnormality
R2262	T10049	T10047	pobj	abnormality,without
R2263	T10050	T10049	amod	histological,abnormality
R2264	T10051	T10049	punct	", ",abnormality
R2265	T10052	T10049	prep	including,abnormality
R2266	T10053	T10054	det	the,brain
R2267	T10054	T10052	pobj	brain,including
R2268	T10055	T10054	punct	", ",brain
R2269	T10105	T10104	pcomp	examining,on
R227	T2213	T2210	appos	Disintegrin,ADAM
R2270	T10056	T10054	conj	heart,brain
R2271	T10057	T10056	punct	", ",heart
R2272	T10106	T10107	det	the,tests
R2273	T10107	T10105	dobj	tests,examining
R2274	T10108	T10109	npadvmod	hippocampus,dependent
R2275	T10058	T10056	conj	liver,heart
R2276	T10109	T10107	amod	dependent,tests
R2277	T10110	T10108	punct	-,hippocampus
R2278	T10059	T10058	cc	and,liver
R2279	T10111	T10108	cc	and,hippocampus
R228	T2214	T2213	cc	And,Disintegrin
R2280	T10112	T10108	conj	cerebellum,hippocampus
R2281	T10113	T10109	punct	-,dependent
R2282	T10060	T10058	conj	testis,liver
R2283	T10114	T10107	amod	behavioural,tests
R2284	T10115	T10116	aux	to,study
R2285	T10061	T10034	punct	.,appeared
R2286	T10116	T10102	advcl	study,focused
R2287	T10117	T10118	det	the,functions
R2288	T10118	T10116	dobj	functions,study
R2289	T10063	T10064	det	The,patterns
R229	T2215	T2213	conj	Metalloprotease,Disintegrin
R2290	T10119	T10118	prep	of,functions
R2291	T10064	T10066	nsubjpass	patterns,studied
R2292	T10120	T10119	pobj	ADAM11,of
R2293	T10121	T10118	prep	in,functions
R2294	T10122	T10123	det	the,system
R2295	T10123	T10121	pobj	system,in
R2296	T10124	T10123	amod	nervous,system
R2297	T10065	T10064	compound	expression,patterns
R2298	T10125	T10102	punct	.,focused
R2299	T10067	T10064	prep	of,patterns
R23	T593	T583	conj	expressed,is
R230	T2216	T2209	punct	),family
R2300	T10127	T10128	nsubjpass	It,accepted
R2301	T10129	T10128	auxpass	is,accepted
R2302	T10130	T10128	advmod	widely,accepted
R2303	T10068	T10069	det	the,gene
R2304	T10131	T10132	mark	that,involved
R2305	T10132	T10128	ccomp	involved,accepted
R2306	T10069	T10067	pobj	gene,of
R2307	T10133	T10134	det	the,hippocampus
R2308	T10134	T10132	nsubjpass	hippocampus,involved
R2309	T10135	T10132	auxpass	is,involved
R231	T2218	T2219	npadvmod	membrane,spanning
R2310	T10070	T10069	compound	Adam11,gene
R2311	T10136	T10132	prep	in,involved
R2312	T10071	T10064	prep	in,patterns
R2313	T10137	T10138	det	the,performance
R2314	T10138	T10136	pobj	performance,in
R2315	T10139	T10138	prep	of,performance
R2316	T10140	T10141	det	the,version
R2317	T10141	T10139	pobj	version,of
R2318	T10072	T10073	det	the,brain
R2319	T10142	T10143	amod	hidden,platform
R232	T2219	T2221	amod	spanning,proteins
R2320	T10143	T10141	compound	platform,version
R2321	T10144	T10141	prep	of,version
R2322	T10073	T10071	pobj	brain,in
R2323	T10145	T10146	det	the,test
R2324	T10146	T10144	pobj	test,of
R2325	T10147	T10148	compound	water,maze
R2326	T10074	T10066	aux	have,studied
R2327	T10148	T10146	compound	maze,test
R2328	T10149	T10128	punct	", ",accepted
R2329	T10150	T10151	mark	since,lead
R233	T2220	T2219	punct	-,spanning
R2330	T10075	T10066	auxpass	been,studied
R2331	T10151	T10128	advcl	lead,accepted
R2332	T10152	T10151	nsubj	lesions,lead
R2333	T10153	T10152	prep	of,lesions
R2334	T10076	T10066	advcl	using,studied
R2335	T10154	T10155	det	the,pathways
R2336	T10155	T10153	pobj	pathways,of
R2337	T10156	T10155	amod	hippocampal,pathways
R2338	T10077	T10078	advmod	in,situ
R2339	T10157	T10151	prep	to,lead
R234	T2221	T2217	dobj	proteins,comprises
R2340	T10158	T10159	det	a,impairment
R2341	T10159	T10157	pobj	impairment,to
R2342	T10078	T10079	amod	situ,hybridisation
R2343	T10160	T10159	amod	severe,impairment
R2344	T10161	T10159	prep	of,impairment
R2345	T10162	T10161	pobj	learning,of
R2346	T10163	T10151	prep	in,lead
R2347	T10164	T10165	det	this,task
R2348	T10165	T10163	pobj	task,in
R2349	T10079	T10076	dobj	hybridisation,using
R235	T2222	T2221	amod	multi-domain,proteins
R2350	T10166	T10167	punct	[,29
R2351	T10167	T10151	parataxis	29,lead
R2352	T10168	T10167	punct	],29
R2353	T10080	T10081	punct	[,25
R2354	T10169	T10128	punct	.,accepted
R2355	T10171	T10172	prep	In,needed
R2356	T10081	T10066	parataxis	25,studied
R2357	T10173	T10174	det	the,task
R2358	T10174	T10171	pobj	task,In
R2359	T10082	T10081	punct	],25
R236	T2223	T2221	acl	containing,proteins
R2360	T10175	T10176	amod	hidden,platform
R2361	T10176	T10174	compound	platform,task
R2362	T10177	T10172	punct	", ",needed
R2363	T10083	T10066	punct	.,studied
R2364	T10178	T10179	npadvmod	ADAM11,deficient
R2365	T10179	T10181	amod	deficient,mice
R2366	T10180	T10179	punct	-,deficient
R2367	T10085	T10086	det	This,study
R2368	T10181	T10172	nsubj	mice,needed
R2369	T10182	T10183	amod	more,time
R237	T2224	T2225	det	a,domain
R2370	T10183	T10172	dobj	time,needed
R2371	T10184	T10185	aux	to,reach
R2372	T10086	T10087	nsubj	study,shown
R2373	T10185	T10183	advcl	reach,time
R2374	T10186	T10187	det	the,platform
R2375	T10187	T10185	dobj	platform,reach
R2376	T10088	T10087	aux	has,shown
R2377	T10188	T10183	prep	than,time
R2378	T10189	T10190	amod	wild,type
R2379	T10190	T10192	compound	type,mice
R238	T2225	T2223	dobj	domain,containing
R2380	T10191	T10190	punct	-,type
R2381	T10089	T10090	amod	high,expression
R2382	T10192	T10188	pobj	mice,than
R2383	T10193	T10172	punct	.,needed
R2384	T10090	T10087	dobj	expression,shown
R2385	T10195	T10196	amod	Spatial,learning
R2386	T10196	T10197	nsubjpass	learning,assessed
R2387	T10091	T10090	prep	of,expression
R2388	T10198	T10197	auxpass	was,assessed
R2389	T10199	T10197	advmod	also,assessed
R239	T2226	T2227	npadvmod	metalloproteinase,like
R2390	T10200	T10197	advcl	using,assessed
R2391	T10092	T10093	compound	ADAM11,mRNA
R2392	T10201	T10202	det	a,trial
R2393	T10202	T10200	dobj	trial,using
R2394	T10203	T10202	compound	probe,trial
R2395	T10093	T10091	pobj	mRNA,of
R2396	T10204	T10202	punct	", ",trial
R2397	T10205	T10206	prep	in,removed
R2398	T10206	T10202	relcl	removed,trial
R2399	T10094	T10090	prep	in,expression
R24	T594	T593	advmod	mainly,expressed
R240	T2227	T2225	amod	like,domain
R2400	T10207	T10205	pobj	which,in
R2401	T10208	T10209	det	the,platform
R2402	T10209	T10206	nsubjpass	platform,removed
R2403	T10095	T10096	det	the,hippocampus
R2404	T10210	T10206	auxpass	was,removed
R2405	T10096	T10094	pobj	hippocampus,in
R2406	T10097	T10096	cc	and,hippocampus
R2407	T10098	T10096	conj	cerebellum,hippocampus
R2408	T10099	T10087	punct	.,shown
R2409	T10211	T10206	prep	from,removed
R241	T2228	T2227	punct	-,like
R2410	T10212	T10213	det	the,pool
R2411	T10213	T10211	pobj	pool,from
R2412	T10101	T10102	nsubj	We,focused
R2413	T10214	T10206	prep	on,removed
R2414	T10215	T10216	det	the,day
R2415	T10216	T10214	pobj	day,on
R2416	T10103	T10102	advmod	therefore,focused
R2417	T10217	T10216	prep	following,day
R2418	T10218	T10219	nummod	nine,days
R2419	T10104	T10102	prep	on,focused
R242	T2229	T2225	cc	and,domain
R2420	T10219	T10217	pobj	days,following
R2421	T10220	T10219	prep	of,days
R2422	T10221	T10220	pobj	training,of
R2423	T10222	T10197	punct	.,assessed
R2424	T10317	T10318	det	the,coordination
R2425	T10224	T10225	det	The,mice
R2426	T10225	T10229	nsubj	mice,spent
R2427	T10318	T10316	pobj	coordination,of
R2428	T10226	T10227	amod	wild,type
R2429	T10227	T10225	compound	type,mice
R243	T2230	T2231	det	a,domain
R2430	T10228	T10227	punct	-,type
R2431	T10319	T10318	amod	smooth,coordination
R2432	T10230	T10231	advmod	significantly,more
R2433	T10231	T10232	amod	more,time
R2434	T10320	T10318	prep	of,coordination
R2435	T10232	T10229	dobj	time,spent
R2436	T10233	T10229	xcomp	searching,spent
R2437	T10321	T10322	amod	somatic,activity
R2438	T10234	T10233	prep	for,searching
R2439	T10235	T10236	det	the,platform
R244	T2231	T2225	conj	domain,domain
R2440	T10236	T10234	pobj	platform,for
R2441	T10322	T10320	pobj	activity,of
R2442	T10237	T10233	prep	in,searching
R2443	T10238	T10239	det	the,quadrant
R2444	T10239	T10237	pobj	quadrant,in
R2445	T10323	T10322	compound	motor,activity
R2446	T10240	T10239	compound	target,quadrant
R2447	T10241	T10229	prep	than,spent
R2448	T10242	T10243	det	the,quadrants
R2449	T10243	T10241	pobj	quadrants,than
R245	T2232	T2233	npadvmod	disintegrin,like
R2450	T10244	T10243	amod	other,quadrants
R2451	T10245	T10229	punct	.,spent
R2452	T10324	T10318	punct	", ",coordination
R2453	T10247	T10248	advmod	However,search
R2454	T10325	T10318	conj	regulation,coordination
R2455	T10249	T10248	punct	", ",search
R2456	T10250	T10251	npadvmod	ADAM11,deficient
R2457	T10326	T10325	prep	of,regulation
R2458	T10251	T10253	amod	deficient,mice
R2459	T10252	T10251	punct	-,deficient
R246	T2233	T2231	amod	like,domain
R2460	T10253	T10248	nsubj	mice,search
R2461	T10327	T10328	compound	muscle,tone
R2462	T10254	T10248	aux	did,search
R2463	T10255	T10248	neg	not,search
R2464	T10256	T10248	advmod	selectively,search
R2465	T10328	T10326	pobj	tone,of
R2466	T10257	T10248	prep	in,search
R2467	T10258	T10259	det	the,quadrant
R2468	T10259	T10257	pobj	quadrant,in
R2469	T10329	T10325	punct	", ",regulation
R247	T2234	T2233	punct	-,like
R2470	T10260	T10259	compound	target,quadrant
R2471	T10261	T10248	punct	.,search
R2472	T10330	T10325	cc	and,regulation
R2473	T10263	T10264	prep	On,were
R2474	T10331	T10325	conj	mechanisms,regulation
R2475	T10265	T10266	det	the,hand
R2476	T10266	T10263	pobj	hand,On
R2477	T10332	T10333	dep	that,influence
R2478	T10267	T10266	amod	other,hand
R2479	T10268	T10264	punct	", ",were
R248	T2235	T2217	punct	.,comprises
R2480	T10269	T10264	prep	in,were
R2481	T10333	T10331	relcl	influence,mechanisms
R2482	T10270	T10271	det	the,version
R2483	T10271	T10269	pobj	version,in
R2484	T10272	T10273	amod	visible,platform
R2485	T10334	T10333	cc	and,influence
R2486	T10273	T10271	compound	platform,version
R2487	T10274	T10271	punct	", ",version
R2488	T10275	T10276	prep	in,tested
R2489	T10335	T10333	conj	maintain,influence
R249	T2237	T2238	advmod	Approximately,half
R2490	T10276	T10271	relcl	tested,version
R2491	T10277	T10275	pobj	which,in
R2492	T10278	T10279	det	the,ability
R2493	T10336	T10335	dobj	equilibrium,maintain
R2494	T10279	T10276	nsubjpass	ability,tested
R2495	T10280	T10279	amod	motor,ability
R2496	T10281	T10279	cc	and,ability
R2497	T10337	T10338	punct	[,30
R2498	T10282	T10283	amod	visual,acuity
R2499	T10283	T10279	conj	acuity,ability
R25	T595	T593	prep	in,expressed
R250	T2238	T2239	nsubj	half,are
R2500	T10284	T10279	prep	of,ability
R2501	T10285	T10286	det	the,mouse
R2502	T10286	T10284	pobj	mouse,of
R2503	T10287	T10276	auxpass	are,tested
R2504	T10288	T10264	punct	", ",were
R2505	T10338	T10313	parataxis	30,is
R2506	T10289	T10290	npadvmod	ADAM11,defieient
R2507	T10290	T10292	amod	defieient,mice
R2508	T10291	T10290	punct	-,defieient
R2509	T10339	T10338	punct	],30
R251	T2240	T2238	prep	of,half
R2510	T10292	T10264	nsubj	mice,were
R2511	T10293	T10264	acomp	normal,were
R2512	T10340	T10313	punct	.,is
R2513	T10342	T10343	nsubjpass	It,accepted
R2514	T10294	T10264	punct	.,were
R2515	T10344	T10343	auxpass	is,accepted
R2516	T10296	T10297	det	These,results
R2517	T10297	T10298	nsubj	results,indicated
R2518	T10299	T10300	mark	that,showed
R2519	T10345	T10343	advmod	widely,accepted
R252	T2241	T2242	det	the,ADAMs
R2520	T10300	T10298	ccomp	showed,indicated
R2521	T10301	T10302	npadvmod	ADAM11,deficient
R2522	T10302	T10304	amod	deficient,mice
R2523	T10346	T10347	mark	that,involved
R2524	T10303	T10302	punct	-,deficient
R2525	T10304	T10300	nsubj	mice,showed
R2526	T10347	T10343	ccomp	involved,accepted
R2527	T10305	T10306	det	a,impairment
R2528	T10348	T10349	det	the,cerebellum
R2529	T10306	T10300	dobj	impairment,showed
R253	T2242	T2240	pobj	ADAMs,of
R2530	T10307	T10308	amod	spatial,learning
R2531	T10308	T10306	compound	learning,impairment
R2532	T10349	T10347	nsubjpass	cerebellum,involved
R2533	T10309	T10298	punct	.,indicated
R2534	T10311	T10312	det	The,cerebellum
R2535	T10350	T10347	auxpass	is,involved
R2536	T10312	T10313	nsubj	cerebellum,is
R2537	T10351	T10347	prep	in,involved
R2538	T10314	T10313	prep	in,is
R2539	T10315	T10314	pobj	charge,in
R254	T2243	T2244	advmod	catalytically,active
R2540	T10316	T10315	prep	of,charge
R2541	T10352	T10353	det	the,performance
R2542	T10353	T10351	pobj	performance,in
R2543	T10354	T10353	prep	of,performance
R2544	T10355	T10356	det	the,task
R2545	T10423	T10421	pobj	rpm,at
R2546	T10356	T10354	pobj	task,of
R2547	T10424	T10425	punct	(,stationary
R2548	T10425	T10423	parataxis	stationary,rpm
R2549	T10357	T10358	amod	rotating,rod
R255	T2244	T2245	amod	active,metalloproteases
R2550	T10426	T10425	punct	),stationary
R2551	T10427	T10392	punct	", ",fell
R2552	T10358	T10356	compound	rod,task
R2553	T10428	T10429	npadvmod	ADAM11,deficient
R2554	T10429	T10431	amod	deficient,mice
R2555	T10430	T10429	punct	-,deficient
R2556	T10431	T10392	nsubj	mice,fell
R2557	T10432	T10433	advmod	more,quickly
R2558	T10433	T10392	advmod	quickly,fell
R2559	T10359	T10343	punct	", ",accepted
R256	T2245	T2239	attr	metalloproteases,are
R2560	T10434	T10392	prep	from,fell
R2561	T10435	T10436	det	the,rod
R2562	T10436	T10434	pobj	rod,from
R2563	T10360	T10361	mark	since,exhibit
R2564	T10437	T10392	prep	than,fell
R2565	T10438	T10439	amod	wild,type
R2566	T10439	T10441	compound	type,mice
R2567	T10361	T10343	advcl	exhibit,accepted
R2568	T10440	T10439	punct	-,type
R2569	T10441	T10437	pobj	mice,than
R257	T2246	T2247	dep	that,shed
R2570	T10442	T10392	prep	at,fell
R2571	T10362	T10361	nsubj	mice,exhibit
R2572	T10443	T10444	nummod	5,rpm
R2573	T10444	T10442	pobj	rpm,at
R2574	T10445	T10443	punct	", ",5
R2575	T10363	T10362	prep	with,mice
R2576	T10446	T10443	conj	10,5
R2577	T10447	T10446	cc	and,10
R2578	T10448	T10446	conj	15,10
R2579	T10364	T10365	amod	structural,abnormalities
R258	T2247	T2245	relcl	shed,metalloproteases
R2580	T10449	T10392	punct	.,fell
R2581	T10451	T10452	det	These,results
R2582	T10365	T10363	pobj	abnormalities,with
R2583	T10452	T10453	nsubj	results,indicate
R2584	T10454	T10455	mark	that,have
R2585	T10366	T10365	prep	in,abnormalities
R2586	T10455	T10453	ccomp	have,indicate
R2587	T10456	T10457	npadvmod	ADAM11,deficient
R2588	T10367	T10368	det	the,cerebellum
R2589	T10457	T10459	amod	deficient,mice
R259	T2248	T2249	det	a,range
R2590	T10458	T10457	punct	-,deficient
R2591	T10459	T10455	nsubj	mice,have
R2592	T10368	T10366	pobj	cerebellum,in
R2593	T10460	T10461	det	a,deficit
R2594	T10461	T10455	dobj	deficit,have
R2595	T10462	T10461	prep	in,deficit
R2596	T10369	T10370	punct	[,31
R2597	T10463	T10464	compound	motor,coordination
R2598	T10464	T10462	pobj	coordination,in
R2599	T10465	T10453	punct	.,indicate
R26	T596	T597	det	the,system
R260	T2249	T2247	dobj	range,shed
R2600	T10370	T10365	parataxis	31,abnormalities
R2601	T10371	T10370	punct	],31
R2602	T10467	T10468	prep	On,was
R2603	T10372	T10363	cc	or,with
R2604	T10469	T10470	det	the,hand
R2605	T10470	T10467	pobj	hand,On
R2606	T10471	T10470	amod	other,hand
R2607	T10472	T10468	punct	", ",was
R2608	T10473	T10468	prep	in,was
R2609	T10474	T10475	det	the,version
R261	T2250	T2249	amod	broad,range
R2610	T10373	T10363	conj	with,with
R2611	T10475	T10473	pobj	version,in
R2612	T10476	T10477	amod	visual,platform
R2613	T10374	T10373	pobj	disruptions,with
R2614	T10477	T10475	compound	platform,version
R2615	T10478	T10475	prep	of,version
R2616	T10479	T10480	det	the,task
R2617	T10375	T10374	prep	in,disruptions
R2618	T10480	T10478	pobj	task,of
R2619	T10481	T10482	compound	water,maze
R262	T2251	T2249	prep	of,range
R2620	T10482	T10480	compound	maze,task
R2621	T10376	T10375	pobj	genes,in
R2622	T10483	T10468	punct	", ",was
R2623	T10484	T10485	compound	motor,ability
R2624	T10485	T10468	nsubj	ability,was
R2625	T10377	T10376	acl	enriched,genes
R2626	T10486	T10485	prep	for,ability
R2627	T10487	T10486	pobj	swimming,for
R2628	T10488	T10485	prep	in,ability
R2629	T10378	T10377	prep	in,enriched
R263	T2252	T2251	pobj	substrates,of
R2630	T10489	T10490	npadvmod	ADAM11,deficient
R2631	T10490	T10492	amod	deficient,mice
R2632	T10491	T10490	punct	-,deficient
R2633	T10379	T10380	det	the,cerebellum
R2634	T10492	T10488	pobj	mice,in
R2635	T10493	T10468	acomp	normal,was
R2636	T10494	T10468	punct	.,was
R2637	T10380	T10378	pobj	cerebellum,in
R2638	T10496	T10497	det	These,results
R2639	T10497	T10498	nsubj	results,suggested
R264	T2253	T2252	punct	", ",substrates
R2640	T10381	T10382	punct	[,32
R2641	T10382	T10374	parataxis	32,disruptions
R2642	T10499	T10500	mark	that,be
R2643	T10500	T10498	ccomp	be,suggested
R2644	T10501	T10500	expl	there,be
R2645	T10502	T10500	aux	might,be
R2646	T10383	T10382	punct	],32
R2647	T10503	T10504	det	a,mechanism
R2648	T10504	T10500	attr	mechanism,be
R2649	T10505	T10504	amod	different,mechanism
R265	T2254	T2255	amod	such,as
R2650	T10384	T10385	compound	performance,deficits
R2651	T10506	T10504	prep	of,mechanism
R2652	T10507	T10508	compound	motor,function
R2653	T10508	T10506	pobj	function,of
R2654	T10385	T10361	dobj	deficits,exhibit
R2655	T10509	T10504	prep	between,mechanism
R2656	T10510	T10509	pobj	swimming,between
R2657	T10511	T10510	cc	and,swimming
R2658	T10512	T10513	det	the,task
R2659	T10513	T10510	conj	task,swimming
R266	T2255	T2252	prep	as,substrates
R2660	T10514	T10515	amod	rotating,rod
R2661	T10515	T10513	compound	rod,task
R2662	T10386	T10361	prep	in,exhibit
R2663	T10516	T10498	punct	.,suggested
R2664	T10387	T10388	det	this,task
R2665	T10518	T10519	nsubjpass	It,reported
R2666	T10520	T10519	aux	has,reported
R2667	T10388	T10386	pobj	task,in
R2668	T10521	T10519	auxpass	been,reported
R2669	T10522	T10519	advmod	also,reported
R267	T2256	T2255	pobj	cytokines,as
R2670	T10523	T10524	mark	that,involved
R2671	T10389	T10343	punct	.,accepted
R2672	T10524	T10519	ccomp	involved,reported
R2673	T10525	T10526	det	the,cerebellum
R2674	T10391	T10392	prep	In,fell
R2675	T10526	T10524	nsubjpass	cerebellum,involved
R2676	T10527	T10524	auxpass	is,involved
R2677	T10528	T10524	prep	in,involved
R2678	T10393	T10394	det	the,test
R2679	T10394	T10391	pobj	test,In
R268	T2257	T2256	punct	", ",cytokines
R2680	T10529	T10530	det	another,function
R2681	T10395	T10396	amod	rotating,rod
R2682	T10530	T10528	pobj	function,in
R2683	T10531	T10530	amod	important,function
R2684	T10532	T10530	amod	distinct,function
R2685	T10396	T10394	compound	rod,test
R2686	T10533	T10530	punct	: ,function
R2687	T10534	T10530	appos	learning,function
R2688	T10397	T10394	prep	in,test
R2689	T10535	T10534	acl	associated,learning
R269	T2258	T2259	compound	growth,factors
R2690	T10536	T10535	prep	with,associated
R2691	T10537	T10538	compound	component,movement
R2692	T10398	T10399	det	this,study
R2693	T10538	T10536	pobj	movement,with
R2694	T10539	T10534	punct	(,learning
R2695	T10399	T10397	pobj	study,in
R2696	T10540	T10541	compound	motor,learning
R2697	T10541	T10534	appos	learning,learning
R2698	T10542	T10524	punct	),involved
R2699	T10400	T10392	punct	", ",fell
R27	T597	T595	pobj	system,in
R270	T2259	T2256	appos	factors,cytokines
R2700	T10543	T10544	punct	[,33
R2701	T10544	T10524	parataxis	33,involved
R2702	T10401	T10402	mark	although,was
R2703	T10545	T10544	punct	],33
R2704	T10546	T10519	punct	.,reported
R2705	T10402	T10392	advcl	was,fell
R2706	T10548	T10549	det	The,time
R2707	T10549	T10551	nsubj	time,was
R2708	T10550	T10549	compound	retention,time
R2709	T10403	T10404	det	the,time
R271	T2260	T2256	punct	", ",cytokines
R2710	T10552	T10549	prep	of,time
R2711	T10553	T10554	npadvmod	synaptotagmin,deficient
R2712	T10404	T10402	nsubj	time,was
R2713	T10554	T10560	amod	deficient,mice
R2714	T10555	T10553	punct	(,synaptotagmin
R2715	T10556	T10557	nmod	Syt,IV
R2716	T10405	T10404	compound	retention,time
R2717	T10557	T10553	appos	IV,synaptotagmin
R2718	T10558	T10557	punct	),IV
R2719	T10559	T10554	punct	-,deficient
R272	T2261	T2256	appos	receptors,cytokines
R2720	T10406	T10404	prep	of,time
R2721	T10560	T10552	pobj	mice,of
R2722	T10561	T10549	prep	on,time
R2723	T10562	T10563	det	the,rod
R2724	T10407	T10408	npadvmod	ADAM11,deficient
R2725	T10563	T10561	pobj	rod,on
R2726	T10564	T10565	advmod	significantly,shorter
R2727	T10408	T10410	amod	deficient,mice
R2728	T10565	T10551	acomp	shorter,was
R2729	T10566	T10565	prep	than,shorter
R273	T2262	T2256	punct	", ",cytokines
R2730	T10567	T10568	amod	wild,type
R2731	T10409	T10408	punct	-,deficient
R2732	T10568	T10570	compound	type,mice
R2733	T10569	T10568	punct	-,type
R2734	T10570	T10566	pobj	mice,than
R2735	T10410	T10406	pobj	mice,of
R2736	T10571	T10551	punct	", ",was
R2737	T10572	T10551	cc	and,was
R2738	T10573	T10574	nsubj	they,improved
R2739	T10411	T10404	prep	on,time
R274	T2263	T2264	compound	adhesion,molecules
R2740	T10574	T10551	conj	improved,was
R2741	T10575	T10574	dobj	it,improved
R2742	T10576	T10577	advmod	approximately,to
R2743	T10412	T10413	det	the,rod
R2744	T10577	T10574	prep	to,improved
R2745	T10578	T10579	det	the,rates
R2746	T10579	T10577	pobj	rates,to
R2747	T10413	T10411	pobj	rod,on
R2748	T10580	T10579	amod	same,rates
R2749	T10414	T10402	neg	not,was
R275	T2264	T2256	appos	molecules,cytokines
R2750	T10581	T10582	mark	as,did
R2751	T10582	T10574	advcl	did,improved
R2752	T10583	T10584	amod	wild,type
R2753	T10584	T10586	compound	type,mice
R2754	T10415	T10402	acomp	different,was
R2755	T10585	T10584	punct	-,type
R2756	T10586	T10582	nsubj	mice,did
R2757	T10587	T10574	prep	during,improved
R2758	T10416	T10415	prep	from,different
R2759	T10588	T10589	amod	rotating,rod
R276	T2265	T2266	punct	[,2
R2760	T10589	T10590	compound	rod,performance
R2761	T10590	T10587	pobj	performance,during
R2762	T10591	T10592	punct	[,34
R2763	T10592	T10574	parataxis	34,improved
R2764	T10593	T10592	punct	],34
R2765	T10594	T10574	punct	.,improved
R2766	T10417	T10418	amod	wild,type
R2767	T10596	T10597	det	These,data
R2768	T10418	T10420	compound	type,mice
R2769	T10597	T10598	nsubj	data,suggest
R277	T2266	T2247	parataxis	2,shed
R2770	T10599	T10600	det	the,basis
R2771	T10600	T10601	nsubj	basis,is
R2772	T10419	T10418	punct	-,type
R2773	T10601	T10598	advcl	is,suggest
R2774	T10602	T10600	prep	for,basis
R2775	T10420	T10416	pobj	mice,from
R2776	T10603	T10604	det	the,deficit
R2777	T10604	T10602	pobj	deficit,for
R2778	T10605	T10604	compound	performance,deficit
R2779	T10421	T10402	prep	at,was
R278	T2267	T2266	nummod	1,2
R2780	T10606	T10604	prep	on,deficit
R2781	T10607	T10608	det	the,task
R2782	T10608	T10606	pobj	task,on
R2783	T10422	T10423	nummod	0,rpm
R2784	T10609	T10610	amod	rotating,rod
R2785	T10610	T10608	compound	rod,task
R2786	T10611	T10604	prep	in,deficit
R2787	T10612	T10613	det	the,mutants
R2788	T10635	T10636	npadvmod	ADAM11,deficient
R2789	T10613	T10611	pobj	mutants,in
R279	T2268	T2266	punct	",",2
R2790	T10614	T10613	nmod	Syt,mutants
R2791	T10615	T10614	nummod	IV,Syt
R2792	T10636	T10638	amod	deficient,mice
R2793	T10616	T10601	prep	in,is
R2794	T10617	T10618	compound	motor,coordination
R2795	T10618	T10616	pobj	coordination,in
R2796	T10637	T10636	punct	-,deficient
R2797	T10619	T10620	advmod	rather,than
R2798	T10620	T10616	cc	than,in
R2799	T10638	T10634	nsubj	mice,improved
R28	T598	T597	amod	nervous,system
R280	T2269	T2266	punct	],2
R2800	T10621	T10616	conj	in,in
R2801	T10622	T10623	compound	motor,learning
R2802	T10639	T10634	advmod	slightly,improved
R2803	T10623	T10621	pobj	learning,in
R2804	T10624	T10598	punct	.,suggest
R2805	T10640	T10639	punct	", ",slightly
R2806	T10626	T10627	det	The,results
R2807	T10627	T10628	nsubj	results,showed
R2808	T10641	T10639	cc	though,slightly
R2809	T10629	T10627	prep	in,results
R281	T2270	T2239	punct	.,are
R2810	T10630	T10631	det	the,study
R2811	T10631	T10629	pobj	study,in
R2812	T10642	T10641	neg	not,though
R2813	T10632	T10631	amod	present,study
R2814	T10633	T10634	mark	that,improved
R2815	T10643	T10639	conj	significantly,slightly
R2816	T10634	T10628	ccomp	improved,showed
R2817	T10644	T10634	punct	", ",improved
R2818	T10645	T10646	compound	motor,learning
R2819	T10646	T10647	compound	learning,ability
R282	T2272	T2273	amod	Recent,studies
R2820	T10741	T10740	punct	-,deficient
R2821	T10742	T10738	pobj	mice,in
R2822	T10647	T10634	dobj	ability,improved
R2823	T10743	T10727	punct	.,was
R2824	T10648	T10634	prep	during,improved
R2825	T10745	T10746	amod	Spontaneous,activity
R2826	T10746	T10748	nsubjpass	activity,found
R2827	T10747	T10746	compound	motor,activity
R2828	T10649	T10650	amod	rotating,rod
R2829	T10749	T10746	cc	and,activity
R283	T2273	T2277	nsubj	studies,disclosed
R2830	T10750	T10751	amod	walking,patterns
R2831	T10751	T10746	conj	patterns,activity
R2832	T10650	T10651	compound	rod,performance
R2833	T10752	T10746	prep	of,activity
R2834	T10753	T10754	npadvmod	ADAM11,deficient
R2835	T10754	T10756	amod	deficient,mice
R2836	T10651	T10648	pobj	performance,during
R2837	T10755	T10754	punct	-,deficient
R2838	T10756	T10752	pobj	mice,of
R2839	T10757	T10748	auxpass	were,found
R284	T2274	T2275	compound	gene,disruption
R2840	T10652	T10628	punct	.,showed
R2841	T10758	T10748	advmod	also,found
R2842	T10759	T10760	aux	to,be
R2843	T10760	T10748	xcomp	be,found
R2844	T10654	T10655	advmod	However,was
R2845	T10761	T10760	acomp	normal,be
R2846	T10762	T10760	punct	", ",be
R2847	T10763	T10760	advcl	suggesting,be
R2848	T10764	T10765	mark	that,derived
R2849	T10656	T10655	punct	", ",was
R285	T2275	T2273	compound	disruption,studies
R2850	T10765	T10763	ccomp	derived,suggesting
R2851	T10766	T10767	det	the,dysfunction
R2852	T10767	T10765	nsubjpass	dysfunction,derived
R2853	T10768	T10767	acl	found,dysfunction
R2854	T10657	T10658	det	the,deficit
R2855	T10769	T10768	prep	in,found
R2856	T10770	T10771	det	the,test
R2857	T10658	T10655	nsubj	deficit,was
R2858	T10771	T10769	pobj	test,in
R2859	T10772	T10773	amod	rotating,rod
R286	T2276	T2275	punct	-,disruption
R2860	T10773	T10771	compound	rod,test
R2861	T10659	T10658	prep	of,deficit
R2862	T10774	T10765	auxpass	was,derived
R2863	T10775	T10765	neg	not,derived
R2864	T10776	T10765	prep	from,derived
R2865	T10660	T10661	compound	motor,learning
R2866	T10777	T10778	compound	muscle,weakness
R2867	T10778	T10776	pobj	weakness,from
R2868	T10779	T10778	cc	or,weakness
R2869	T10780	T10781	amod	other,disturbances
R287	T2278	T2273	prep	in,studies
R2870	T10781	T10778	conj	disturbances,weakness
R2871	T10782	T10781	amod	peripheral,disturbances
R2872	T10661	T10659	pobj	learning,of
R2873	T10783	T10748	punct	.,found
R2874	T10785	T10786	det	These,results
R2875	T10662	T10658	prep	in,deficit
R2876	T10786	T10787	nsubj	results,suggest
R2877	T10788	T10789	mark	that,contribute
R2878	T10663	T10664	npadvmod	ADAM11,deficient
R2879	T10789	T10787	ccomp	contribute,suggest
R288	T2279	T2278	pobj	mice,in
R2880	T10790	T10791	amod	limited,sites
R2881	T10664	T10666	amod	deficient,mice
R2882	T10791	T10789	nsubj	sites,contribute
R2883	T10792	T10791	compound	brain,sites
R2884	T10793	T10791	punct	", ",sites
R2885	T10665	T10664	punct	-,deficient
R2886	T10794	T10795	advmod	mainly,hippocampus
R2887	T10795	T10791	appos	hippocampus,sites
R2888	T10796	T10795	det	the,hippocampus
R2889	T10666	T10662	pobj	mice,in
R289	T2280	T2277	aux	have,disclosed
R2890	T10797	T10795	cc	and,hippocampus
R2891	T10798	T10795	conj	cerebellum,hippocampus
R2892	T10799	T10789	punct	", ",contribute
R2893	T10667	T10655	neg	not,was
R2894	T10800	T10789	aux	might,contribute
R2895	T10801	T10789	prep	to,contribute
R2896	T10802	T10803	det	the,phenotype
R2897	T10668	T10655	acomp	clear,was
R2898	T10803	T10801	pobj	phenotype,to
R2899	T10804	T10803	amod	dominant,phenotype
R29	T599	T583	punct	.,is
R290	T2281	T2282	det	a,role
R2900	T10805	T10803	punct	", ",phenotype
R2901	T10669	T10655	prep	in,was
R2902	T10806	T10807	amod	spatial,learning
R2903	T10807	T10808	compound	learning,impairment
R2904	T10808	T10803	appos	impairment,phenotype
R2905	T10670	T10671	det	this,study
R2906	T10809	T10808	cc	and,impairment
R2907	T10810	T10811	compound	motor,discoordination
R2908	T10811	T10808	conj	discoordination,impairment
R2909	T10671	T10669	pobj	study,in
R291	T2282	T2277	dobj	role,disclosed
R2910	T10812	T10789	prep	in,contribute
R2911	T10813	T10814	npadvmod	ADAM11,deficient
R2912	T10672	T10655	punct	.,was
R2913	T10674	T10675	mark	Because,ride
R2914	T10675	T10679	advcl	ride,learn
R2915	T10814	T10816	amod	deficient,mice
R2916	T10676	T10675	nsubj	they,ride
R2917	T10815	T10814	punct	-,deficient
R2918	T10816	T10812	pobj	mice,in
R2919	T10817	T10787	punct	.,suggest
R292	T2283	T2282	amod	physiological,role
R2920	T10677	T10675	aux	could,ride
R2921	T10819	T10820	advmod	In,situ
R2922	T10820	T10821	amod	situ,hybridisation
R2923	T10821	T10822	compound	hybridisation,analysis
R2924	T10678	T10675	neg	not,ride
R2925	T10822	T10823	nsubj	analysis,detected
R2926	T10824	T10823	aux	has,detected
R2927	T10680	T10675	prep	on,ride
R2928	T10825	T10826	compound	Adam11,gene
R2929	T10826	T10827	compound	gene,expression
R293	T2284	T2282	prep	of,role
R2930	T10827	T10823	dobj	expression,detected
R2931	T10681	T10682	det	the,rod
R2932	T10828	T10823	prep	in,detected
R2933	T10829	T10830	det	the,cells
R2934	T10682	T10680	pobj	rod,on
R2935	T10830	T10828	pobj	cells,in
R2936	T10831	T10830	amod	pyramidal,cells
R2937	T10832	T10830	prep	of,cells
R2938	T10683	T10682	amod	rotating,rod
R2939	T10833	T10834	nmod	CA1,fields
R294	T2285	T2286	det	each,ADAM
R2940	T10834	T10832	pobj	fields,of
R2941	T10835	T10836	punct	–,CA3
R2942	T10684	T10679	punct	", ",learn
R2943	T10836	T10833	prep	CA3,CA1
R2944	T10837	T10830	cc	and,cells
R2945	T10685	T10679	nsubj	they,learn
R2946	T10838	T10839	compound	granule,cells
R2947	T10839	T10830	conj	cells,cells
R2948	T10840	T10839	prep	of,cells
R2949	T10686	T10679	aux	might,learn
R295	T2286	T2284	pobj	ADAM,of
R2950	T10841	T10842	det	the,gyrus
R2951	T10842	T10840	pobj	gyrus,of
R2952	T10843	T10842	compound	dentate,gyrus
R2953	T10687	T10679	neg	not,learn
R2954	T10844	T10842	prep	in,gyrus
R2955	T10845	T10846	det	the,hippocampus
R2956	T10846	T10844	pobj	hippocampus,in
R2957	T10688	T10689	det	this,task
R2958	T10689	T10679	dobj	task,learn
R2959	T10690	T10679	punct	.,learn
R296	T2287	T2277	punct	.,disclosed
R2960	T10847	T10844	cc	and,in
R2961	T10848	T10844	conj	in,in
R2962	T10692	T10693	aux	To,examine
R2963	T10849	T10850	amod	granular,cells
R2964	T10850	T10848	pobj	cells,in
R2965	T10851	T10850	prep	in,cells
R2966	T10852	T10853	det	the,cerebellum
R2967	T10693	T10694	advcl	examine,need
R2968	T10853	T10851	pobj	cerebellum,in
R2969	T10854	T10855	punct	[,25
R297	T2289	T2290	prep	For,are
R2970	T10695	T10696	compound	motor,learning
R2971	T10855	T10823	parataxis	25,detected
R2972	T10856	T10855	punct	],25
R2973	T10857	T10823	punct	.,detected
R2974	T10859	T10860	nsubj	It,is
R2975	T10860	T10861	ccomp	is,observed
R2976	T10862	T10860	acomp	unlikely,is
R2977	T10696	T10697	compound	learning,ability
R2978	T10863	T10864	mark	that,led
R2979	T10864	T10860	ccomp	led,is
R298	T2291	T2289	pobj	example,For
R2980	T10865	T10866	amod	morphological,changes
R2981	T10697	T10693	dobj	ability,examine
R2982	T10866	T10864	nsubj	changes,led
R2983	T10867	T10866	prep	during,changes
R2984	T10868	T10867	pobj	development,during
R2985	T10698	T10693	prep	in,examine
R2986	T10869	T10864	prep	to,led
R2987	T10870	T10869	pobj	impairment,to
R2988	T10871	T10870	prep	of,impairment
R2989	T10699	T10700	npadvmod	ADAM11,deficient
R299	T2292	T2290	punct	", ",are
R2990	T10872	T10873	amod	spatial,learning
R2991	T10873	T10871	pobj	learning,of
R2992	T10874	T10873	cc	and,learning
R2993	T10700	T10702	amod	deficient,mice
R2994	T10875	T10876	compound	motor,coordination
R2995	T10876	T10873	conj	coordination,learning
R2996	T10877	T10861	punct	", ",observed
R2997	T10701	T10700	punct	-,deficient
R2998	T10878	T10861	cc	and,observed
R2999	T10879	T10880	amod	morphological,alterations
R3	T567	T565	prep	in,Deficits
R30	T601	T602	nsubjpass	It,thought
R300	T2293	T2290	nsubj	ADAM10,are
R3000	T10880	T10861	nsubjpass	alterations,observed
R3001	T10702	T10698	pobj	mice,in
R3002	T10881	T10880	prep	in,alterations
R3003	T10882	T10883	det	the,cytoarchitecture
R3004	T10883	T10881	pobj	cytoarchitecture,in
R3005	T10703	T10693	prep	in,examine
R3006	T10884	T10883	prep	of,cytoarchitecture
R3007	T10885	T10886	det	the,hippocampus
R3008	T10886	T10884	pobj	hippocampus,of
R3009	T10704	T10703	pobj	detail,in
R301	T2294	T2293	punct	", ",ADAM10
R3010	T10887	T10886	cc	and,hippocampus
R3011	T10888	T10886	conj	cerebellum,hippocampus
R3012	T10889	T10861	auxpass	were,observed
R3013	T10705	T10694	punct	", ",need
R3014	T10890	T10861	neg	not,observed
R3015	T10891	T10861	prep	in,observed
R3016	T10892	T10893	npadvmod	ADAM11,deficient
R3017	T10706	T10694	nsubj	we,need
R3018	T10893	T10895	amod	deficient,mice
R3019	T10894	T10893	punct	-,deficient
R302	T2295	T2293	conj	ADAM17,ADAM10
R3020	T10895	T10891	pobj	mice,in
R3021	T10707	T10694	aux	will,need
R3022	T10896	T10861	prep	after,observed
R3023	T10897	T10898	amod	histological,investigation
R3024	T10898	T10896	pobj	investigation,after
R3025	T10708	T10709	aux	to,use
R3026	T10899	T10898	acl	using,investigation
R3027	T10709	T10694	xcomp	use,need
R3028	T10900	T10901	compound	HE,staining
R3029	T10901	T10899	dobj	staining,using
R303	T2296	T2295	cc	and,ADAM17
R3030	T10710	T10711	amod	other,tasks
R3031	T10902	T10861	punct	.,observed
R3032	T10904	T10905	advmod	However,needed
R3033	T10711	T10709	dobj	tasks,use
R3034	T10906	T10905	punct	", ",needed
R3035	T10712	T10713	amod	cerebellar,dependent
R3036	T10907	T10908	mark	because,thought
R3037	T10908	T10905	advcl	thought,needed
R3038	T10909	T10908	nsubjpass	it,thought
R3039	T10713	T10711	amod	dependent,tasks
R304	T2297	T2295	conj	ADAM19,ADAM17
R3040	T10910	T10908	auxpass	is,thought
R3041	T10911	T10912	mark	that,plays
R3042	T10912	T10908	ccomp	plays,thought
R3043	T10714	T10713	punct	-,dependent
R3044	T10913	T10912	nsubj	ADAM11,plays
R3045	T10914	T10915	det	a,role
R3046	T10715	T10711	compound	learning,tasks
R3047	T10915	T10912	dobj	role,plays
R3048	T10916	T10912	prep	in,plays
R3049	T10917	T10918	nmod	neuron,neuron
R305	T2298	T2290	acomp	critical,are
R3050	T10716	T10711	punct	", ",tasks
R3051	T10918	T10920	nmod	neuron,interactions
R3052	T10919	T10918	punct	-,neuron
R3053	T10920	T10916	pobj	interactions,in
R3054	T10921	T10918	cc	or,neuron
R3055	T10717	T10718	amod	such,as
R3056	T10922	T10923	nmod	neuron,cell
R3057	T10923	T10918	conj	cell,neuron
R3058	T10924	T10923	punct	-,cell
R3059	T10718	T10711	prep	as,tasks
R306	T2299	T2298	prep	for,critical
R3060	T10925	T10923	amod	glial,cell
R3061	T10926	T10905	punct	", ",needed
R3062	T10927	T10928	det	a,investigation
R3063	T10719	T10720	det	a,test
R3064	T10928	T10905	nsubjpass	investigation,needed
R3065	T10929	T10930	advmod	more,precise
R3066	T10930	T10928	amod	precise,investigation
R3067	T10720	T10718	pobj	test,as
R3068	T10931	T10928	amod	morphological,investigation
R3069	T10932	T10905	aux	will,needed
R307	T2300	T2301	amod	normal,development
R3070	T10933	T10905	auxpass	be,needed
R3071	T10721	T10720	amod	classical,test
R3072	T10934	T10905	punct	.,needed
R3073	T10936	T10937	nsubjpass	It,reported
R3074	T10722	T10720	nmod	eyelid,test
R3075	T10938	T10937	aux	has,reported
R3076	T10939	T10937	auxpass	been,reported
R3077	T10940	T10941	mark	that,implicated
R3078	T10941	T10937	ccomp	implicated,reported
R3079	T10723	T10722	amod	conditioning,eyelid
R308	T2301	T2299	pobj	development,for
R3080	T10942	T10943	compound	adhesion,molecules
R3081	T10943	T10941	nsubjpass	molecules,implicated
R3082	T10944	T10943	punct	", ",molecules
R3083	T10724	T10694	punct	.,need
R3084	T10945	T10946	amod	such,as
R3085	T10946	T10943	prep	as,molecules
R3086	T10947	T10948	amod	neural,cell
R3087	T10726	T10727	expl	There,was
R3088	T10948	T10949	compound	cell,molecule
R3089	T10949	T10946	pobj	molecule,as
R309	T2302	T2290	prep	by,are
R3090	T10950	T10949	compound	adhesion,molecule
R3091	T10951	T10949	punct	(,molecule
R3092	T10952	T10949	appos	NCAM,molecule
R3093	T10728	T10729	det	no,impairment
R3094	T10729	T10727	attr	impairment,was
R3095	T10953	T10941	punct	),implicated
R3096	T10730	T10729	prep	in,impairment
R3097	T10954	T10941	punct	", ",implicated
R3098	T10955	T10941	auxpass	are,implicated
R3099	T10731	T10732	det	the,test
R31	T603	T602	auxpass	is,thought
R310	T2303	T2302	pcomp	providing,by
R3100	T10956	T10941	preconj	not,implicated
R3101	T10957	T10956	advmod	only,not
R3102	T10958	T10941	prep	in,implicated
R3103	T10732	T10730	pobj	test,in
R3104	T10959	T10960	compound	cell,interactions
R3105	T10960	T10958	pobj	interactions,in
R3106	T10961	T10941	prep	during,implicated
R3107	T10733	T10734	nmod	grip,strength
R3108	T10962	T10963	amod	nervous,system
R3109	T10963	T10964	compound	system,development
R311	T2304	T2305	compound	growth,signals
R3110	T10964	T10961	pobj	development,during
R3111	T10734	T10732	nmod	strength,test
R3112	T10965	T10941	punct	", ",implicated
R3113	T10966	T10941	cc	but,implicated
R3114	T10967	T10968	auxpass	are,recognised
R3115	T10735	T10734	cc	and,strength
R3116	T10968	T10941	conj	recognised,implicated
R3117	T10969	T10968	advmod	also,recognised
R3118	T10736	T10737	compound	wire,suspension
R3119	T10970	T10968	prep	as,recognised
R312	T2305	T2303	dobj	signals,providing
R3120	T10971	T10972	amod	important,mediators
R3121	T10972	T10970	pobj	mediators,as
R3122	T10737	T10734	conj	suspension,strength
R3123	T10973	T10972	prep	of,mediators
R3124	T10974	T10975	amod	synaptic,plasticity
R3125	T10975	T10973	pobj	plasticity,of
R3126	T10738	T10727	prep	in,was
R3127	T10976	T10968	prep	in,recognised
R3128	T10977	T10978	det	the,system
R3129	T10978	T10976	pobj	system,in
R313	T2306	T2303	prep	at,providing
R3130	T10979	T10978	amod	adult,system
R3131	T10980	T10978	amod	nervous,system
R3132	T10739	T10740	npadvmod	ADAM11,deficient
R3133	T10981	T10982	punct	[,35
R3134	T10982	T10968	parataxis	35,recognised
R3135	T10983	T10937	punct	],reported
R3136	T10740	T10742	amod	deficient,mice
R3137	T11059	T11058	cc	and,dysfunction
R3138	T10984	T10937	punct	.,reported
R3139	T10986	T10987	nsubjpass	Changes,thought
R314	T2307	T2308	det	the,times
R3140	T11060	T11061	amod	complete,loss
R3141	T10988	T10986	prep	in,Changes
R3142	T10989	T10990	compound	neuron,excitability
R3143	T11061	T11058	conj	loss,dysfunction
R3144	T10990	T10988	pobj	excitability,in
R3145	T10991	T10986	prep	in,Changes
R3146	T10992	T10993	det	the,hippocampus
R3147	T11062	T11061	prep	of,loss
R3148	T10993	T10991	pobj	hippocampus,in
R3149	T10994	T10986	punct	", ",Changes
R315	T2308	T2306	pobj	times,at
R3150	T11063	T11064	preconj	both,spontaneous
R3151	T10995	T10996	amod	such,as
R3152	T10996	T10986	prep	as,Changes
R3153	T11064	T11065	amod	spontaneous,currents
R3154	T10997	T10996	pobj	decreases,as
R3155	T10998	T10997	prep	in,decreases
R3156	T10999	T11000	det	the,post-burst
R3157	T11065	T11062	pobj	currents,of
R3158	T11000	T10998	pobj	post-burst,in
R3159	T11001	T10997	prep	after,decreases
R316	T2309	T2308	amod	correct,times
R3160	T11002	T11001	pobj	hyperpolarization,after
R3161	T11003	T11004	punct	(,AHP
R3162	T11004	T11002	parataxis	AHP,hyperpolarization
R3163	T11005	T11004	punct	),AHP
R3164	T11066	T11064	cc	and,spontaneous
R3165	T11006	T10987	punct	", ",thought
R3166	T11007	T10987	aux	have,thought
R3167	T11008	T10987	auxpass	been,thought
R3168	T11067	T11064	conj	evoked,spontaneous
R3169	T11009	T11010	aux	to,affect
R317	T2310	T2308	cc	and,times
R3170	T11010	T10987	xcomp	affect,thought
R3171	T11068	T11065	amod	excitatory,currents
R3172	T11011	T11012	amod	long,term
R3173	T11012	T11014	compound	term,potentiation
R3174	T11013	T11012	punct	-,term
R3175	T11069	T11065	amod	postsynaptic,currents
R3176	T11014	T11010	dobj	potentiation,affect
R3177	T11015	T11014	punct	(,potentiation
R3178	T11016	T11014	appos	LTP,potentiation
R3179	T11070	T11065	punct	(,currents
R318	T2311	T2308	conj	places,times
R3180	T11017	T11010	punct	),affect
R3181	T11018	T11019	punct	[,36
R3182	T11019	T11010	parataxis	36,affect
R3183	T11020	T11019	punct	],36
R3184	T11021	T11010	punct	", ",affect
R3185	T11022	T11023	det	an,model
R3186	T11071	T11065	appos	EPSCs,currents
R3187	T11023	T11010	npadvmod	model,affect
R3188	T11024	T11023	amod	experimental,model
R3189	T11025	T11023	prep	of,model
R319	T2312	T2313	punct	[,3
R3190	T11072	T11046	punct	),showed
R3191	T11026	T11027	det	the,changes
R3192	T11027	T11025	pobj	changes,of
R3193	T11028	T11027	amod	synaptic,changes
R3194	T11073	T11046	prep	in,showed
R3195	T11029	T11027	acl	thought,changes
R3196	T11030	T11031	aux	to,underlie
R3197	T11031	T11029	xcomp	underlie,thought
R3198	T11074	T11075	amod	cerebellar,cells
R3199	T11032	T11031	dobj	learning,underlie
R32	T604	T605	aux	to,be
R320	T2313	T2303	parataxis	3,providing
R3200	T11033	T11032	cc	and,learning
R3201	T11034	T11032	conj	memory,learning
R3202	T11075	T11073	pobj	cells,in
R3203	T11035	T11036	punct	[,37
R3204	T11036	T11029	parataxis	37,thought
R3205	T11037	T11036	punct	],37
R3206	T11076	T11075	compound	granule,cells
R3207	T11038	T10987	punct	.,thought
R3208	T11077	T11078	punct	[,38
R3209	T11040	T11041	nsubjpass	It,reported
R321	T2314	T2315	punct	-,6
R3210	T11042	T11041	aux	has,reported
R3211	T11078	T11046	parataxis	38,showed
R3212	T11043	T11041	advmod	also,reported
R3213	T11044	T11041	auxpass	been,reported
R3214	T11045	T11046	mark	that,showed
R3215	T11046	T11041	ccomp	showed,reported
R3216	T11079	T11078	punct	],38
R3217	T11047	T11046	nsubj	mice,showed
R3218	T11048	T11047	acl	lacking,mice
R3219	T11049	T11050	compound	NMDA,receptor
R322	T2315	T2313	prep	6,3
R3220	T11080	T11041	punct	.,reported
R3221	T11050	T11048	dobj	receptor,lacking
R3222	T11051	T11048	prep	for,lacking
R3223	T11052	T11053	preconj	both,subunits
R3224	T11082	T11083	advmod	Therefore,needed
R3225	T11053	T11051	pobj	subunits,for
R3226	T11054	T11053	nmod	NR2A,subunits
R3227	T11055	T11054	cc	and,NR2A
R3228	T11056	T11054	conj	NR2C,NR2A
R3229	T11084	T11083	punct	", ",needed
R323	T2316	T2313	punct	],3
R3230	T11057	T11058	compound	motor,dysfunction
R3231	T11058	T11046	dobj	dysfunction,showed
R3232	T11085	T11086	amod	electrophyological,studies
R3233	T11086	T11083	nsubjpass	studies,needed
R3234	T11087	T11088	aux	to,enable
R3235	T11165	T11166	det	the,hand
R3236	T11088	T11086	advcl	enable,studies
R3237	T11166	T11163	pobj	hand,On
R3238	T11167	T11166	amod	other,hand
R3239	T11089	T11088	dobj	analysis,enable
R324	T2317	T2290	punct	.,are
R3240	T11168	T11164	punct	", ",showed
R3241	T11169	T11164	nsubj	mice,showed
R3242	T11090	T11089	prep	of,analysis
R3243	T11170	T11169	acl	lacking,mice
R3244	T11171	T11172	det	the,gene
R3245	T11172	T11170	dobj	gene,lacking
R3246	T11091	T11092	amod	synaptic,transmission
R3247	T11173	T11172	compound	Adam22,gene
R3248	T11174	T11175	amod	severe,ataxia
R3249	T11175	T11164	dobj	ataxia,showed
R325	T2319	T2320	prep	In,are
R3250	T11092	T11090	pobj	transmission,of
R3251	T11176	T11164	punct	", ",showed
R3252	T11177	T11164	conj	exhibited,showed
R3253	T11093	T11092	cc	and,transmission
R3254	T11178	T11179	amod	marked,hypomyelination
R3255	T11179	T11177	dobj	hypomyelination,exhibited
R3256	T11180	T11179	prep	of,hypomyelination
R3257	T11094	T11092	conj	plasticity,transmission
R3258	T11181	T11182	det	the,nerves
R3259	T11182	T11180	pobj	nerves,of
R326	T2321	T2319	pobj	contrast,In
R3260	T11183	T11182	amod	peripheral,nerves
R3261	T11095	T11088	prep	in,enable
R3262	T11184	T11177	punct	", ",exhibited
R3263	T11185	T11177	cc	and,exhibited
R3264	T11186	T11177	conj	died,exhibited
R3265	T11096	T11097	det	the,hippocampus
R3266	T11187	T11186	prep	before,died
R3267	T11188	T11187	pobj	weaning,before
R3268	T11189	T11190	punct	[,22
R3269	T11097	T11095	pobj	hippocampus,in
R327	T2322	T2320	punct	", ",are
R3270	T11190	T11186	parataxis	22,died
R3271	T11191	T11190	punct	],22
R3272	T11192	T11164	punct	.,showed
R3273	T11098	T11097	cc	and,hippocampus
R3274	T11194	T11195	nsubj	Mice,showed
R3275	T11099	T11097	conj	cerebellum,hippocampus
R3276	T11196	T11194	acl	lacking,Mice
R3277	T11197	T11198	det	the,gene
R3278	T11100	T11097	prep	of,hippocampus
R3279	T11198	T11196	dobj	gene,lacking
R328	T2323	T2324	det	the,functions
R3280	T11199	T11198	compound	Adam23,gene
R3281	T11200	T11201	amod	severe,ataxia
R3282	T11101	T11102	npadvmod	ADAM11,deficient
R3283	T11201	T11195	dobj	ataxia,showed
R3284	T11102	T11104	amod	deficient,mice
R3285	T11202	T11201	cc	and,ataxia
R3286	T11103	T11102	punct	-,deficient
R3287	T11203	T11201	conj	tremor,ataxia
R3288	T11204	T11195	cc	and,showed
R3289	T11205	T11195	conj	died,showed
R329	T2324	T2320	nsubj	functions,are
R3290	T11104	T11100	pobj	mice,of
R3291	T11206	T11205	prep	before,died
R3292	T11207	T11206	pobj	weaning,before
R3293	T11208	T11209	punct	[,23
R3294	T11105	T11083	aux	will,needed
R3295	T11209	T11205	parataxis	23,died
R3296	T11210	T11209	punct	],23
R3297	T11211	T11195	punct	.,showed
R3298	T11106	T11083	auxpass	be,needed
R3299	T11213	T11214	det	These,findings
R33	T605	T602	xcomp	be,thought
R330	T2325	T2324	prep	of,functions
R3300	T11107	T11083	punct	.,needed
R3301	T11214	T11215	nsubj	findings,suggest
R3302	T11216	T11217	mark	that,have
R3303	T11109	T11110	det	These,studies
R3304	T11217	T11215	ccomp	have,suggest
R3305	T11218	T11217	nsubj	ADAM11,have
R3306	T11219	T11218	punct	", ",ADAM11
R3307	T11110	T11111	nsubj	studies,clarify
R3308	T11220	T11218	conj	ADAM22,ADAM11
R3309	T11221	T11220	cc	and,ADAM22
R331	T2326	T2325	pobj	ADAM8,of
R3310	T11222	T11220	conj	ADAM23,ADAM22
R3311	T11112	T11111	aux	might,clarify
R3312	T11223	T11224	amod	separate,roles
R3313	T11224	T11217	dobj	roles,have
R3314	T11225	T11223	cc	and,separate
R3315	T11226	T11223	conj	important,separate
R3316	T11113	T11114	mark	whether,plays
R3317	T11227	T11224	prep	in,roles
R3318	T11228	T11229	det	the,system
R3319	T11229	T11227	pobj	system,in
R332	T2327	T2326	punct	", ",ADAM8
R3320	T11114	T11111	advcl	plays,clarify
R3321	T11230	T11229	amod	nervous,system
R3322	T11231	T11215	punct	.,suggest
R3323	T11115	T11114	nsubj	ADAM11,plays
R3324	T11233	T11234	det	A,search
R3325	T11234	T11237	nsubj	search,revealed
R3326	T11116	T11117	det	an,role
R3327	T11235	T11234	compound	genome,search
R3328	T11236	T11234	compound	database,search
R3329	T11117	T11114	dobj	role,plays
R333	T2328	T2326	conj	ADAM9,ADAM8
R3330	T11238	T11239	nsubj	orthologs,exist
R3331	T11118	T11117	amod	important,role
R3332	T11239	T11237	ccomp	exist,revealed
R3333	T11119	T11117	nmod	signalling,role
R3334	T11240	T11238	prep	of,orthologs
R3335	T11241	T11242	nmod	ADAM11,genes
R3336	T11120	T11119	cc	or,signalling
R3337	T11242	T11240	pobj	genes,of
R3338	T11243	T11241	punct	", ",ADAM11
R3339	T11244	T11241	conj	ADAM22,ADAM11
R334	T2329	T2328	punct	", ",ADAM9
R3340	T11245	T11244	cc	and,ADAM22
R3341	T11246	T11244	conj	ADAM23,ADAM22
R3342	T11247	T11239	aux	to,exist
R3343	T11121	T11119	conj	structural,signalling
R3344	T11248	T11239	prep	in,exist
R3345	T11249	T11248	pobj	vertebrates,in
R3346	T11122	T11114	prep	at,plays
R3347	T11250	T11251	amod	such,as
R3348	T11251	T11249	prep	as,vertebrates
R3349	T11123	T11124	det	the,level
R335	T2330	T2328	conj	ADAM12,ADAM9
R3350	T11252	T11251	pobj	mammals,as
R3351	T11253	T11252	punct	", ",mammals
R3352	T11254	T11252	conj	fish,mammals
R3353	T11124	T11122	pobj	level,at
R3354	T11255	T11254	punct	", ",fish
R3355	T11256	T11254	cc	and,fish
R3356	T11257	T11254	conj	amphibians,fish
R3357	T11125	T11124	amod	synaptic,level
R3358	T11258	T11248	punct	", ",in
R3359	T11259	T11248	cc	but,in
R336	T2331	T2330	cc	and,ADAM12
R3360	T11260	T11259	neg	not,but
R3361	T11126	T11114	cc	and,plays
R3362	T11261	T11248	conj	in,in
R3363	T11262	T11261	pobj	invertebrates,in
R3364	T11263	T11237	punct	.,revealed
R3365	T11127	T11128	mark	whether,participates
R3366	T11265	T11266	mark	Although,are
R3367	T11128	T11114	conj	participates,plays
R3368	T11266	T11274	advcl	are,provide
R3369	T11267	T11268	det	the,functions
R337	T2332	T2330	conj	ADAM15,ADAM12
R3370	T11268	T11266	nsubj	functions,are
R3371	T11129	T11128	nsubj	it,participates
R3372	T11269	T11268	amod	precise,functions
R3373	T11270	T11268	amod	molecular,functions
R3374	T11130	T11128	prep	in,participates
R3375	T11271	T11268	prep	of,functions
R3376	T11131	T11132	amod	synaptic,regulation
R3377	T11272	T11273	det	these,ADAMs
R3378	T11273	T11271	pobj	ADAMs,of
R3379	T11132	T11130	pobj	regulation,in
R338	T2333	T2320	neg	not,are
R3380	T11275	T11266	advmod	still,are
R3381	T11276	T11266	acomp	unclear,are
R3382	T11133	T11111	punct	.,clarify
R3383	T11277	T11274	punct	", ",provide
R3384	T11278	T11279	amod	further,investigations
R3385	T11279	T11274	nsubj	investigations,provide
R3386	T11135	T11136	npadvmod	ADAM11,deficient
R3387	T11280	T11274	aux	will,provide
R3388	T11281	T11274	dobj	clues,provide
R3389	T11282	T11281	prep	to,clues
R339	T2334	T2320	acomp	essential,are
R3390	T11283	T11282	pcomp	understanding,to
R3391	T11284	T11285	det	the,system
R3392	T11285	T11283	dobj	system,understanding
R3393	T11286	T11285	amod	nervous,system
R3394	T11136	T11138	amod	deficient,mice
R3395	T11287	T11285	prep	of,system
R3396	T11288	T11289	amod	higher,organisms
R3397	T11289	T11287	pobj	organisms,of
R3398	T11137	T11136	punct	-,deficient
R3399	T11290	T11274	punct	.,provide
R34	T606	T607	det	an,molecule
R340	T2335	T2334	prep	for,essential
R3400	T11138	T11139	nsubj	mice,remained
R3401	T11140	T11139	acomp	alive,remained
R3402	T11141	T11139	prep	for,remained
R3403	T11142	T11143	amod	more,one
R3404	T11143	T11145	nummod	one,year
R3405	T11144	T11143	quantmod	than,one
R3406	T11145	T11141	pobj	year,for
R3407	T11146	T11139	prep	without,remained
R3408	T11147	T11146	pobj	ataxia,without
R3409	T11148	T11147	cc	or,ataxia
R341	T2336	T2335	pobj	embryogenesis,for
R3410	T11149	T11147	conj	tremor,ataxia
R3411	T11150	T11139	punct	", ",remained
R3412	T11151	T11139	cc	but,remained
R3413	T11152	T11139	conj	showed,remained
R3414	T11153	T11154	det	a,deficit
R3415	T11154	T11152	dobj	deficit,showed
R3416	T11155	T11154	prep	in,deficit
R3417	T11156	T11157	amod	spatial,learning
R3418	T11157	T11155	pobj	learning,in
R3419	T11158	T11157	cc	and,learning
R342	T2337	T2320	punct	", ",are
R3420	T11159	T11160	compound	motor,dysfunction
R3421	T11160	T11157	conj	dysfunction,learning
R3422	T11161	T11139	punct	.,remained
R3423	T11163	T11164	prep	On,showed
R3424	T11498	T11499	npadvmod	ADAM11,deficient
R3425	T11499	T11501	amod	deficient,mice
R3426	T11500	T11499	punct	-,deficient
R3427	T11501	T11502	nsubj	mice,survived
R3428	T11503	T11504	amod	more,one
R3429	T11504	T11506	nummod	one,year
R343	T2338	T2320	advcl	suggesting,are
R3430	T11505	T11504	quantmod	than,one
R3431	T11506	T11502	npadvmod	year,survived
R3432	T11507	T11502	prep	without,survived
R3433	T11508	T11507	pobj	ataxia,without
R3434	T11509	T11508	cc	or,ataxia
R3435	T11510	T11508	conj	tremor,ataxia
R3436	T11511	T11502	punct	", ",survived
R3437	T11512	T11502	conj	showed,survived
R3438	T11513	T11514	det	no,abnormalities
R3439	T11514	T11512	dobj	abnormalities,showed
R344	T2339	T2340	det	a,redundancy
R3440	T11515	T11514	prep	in,abnormalities
R3441	T11516	T11517	compound	body,weight
R3442	T11517	T11518	compound	weight,gain
R3443	T11518	T11515	pobj	gain,in
R3444	T11519	T11518	punct	", ",gain
R3445	T11520	T11521	amod	spontaneous,activity
R3446	T11521	T11518	conj	activity,gain
R3447	T11522	T11521	compound	motor,activity
R3448	T11523	T11521	punct	", ",activity
R3449	T11524	T11525	compound	muscle,strength
R345	T2340	T2338	dobj	redundancy,suggesting
R3450	T11525	T11521	conj	strength,activity
R3451	T11526	T11525	punct	", ",strength
R3452	T11527	T11525	cc	or,strength
R3453	T11528	T11529	compound	walking,patterns
R3454	T11529	T11525	conj	patterns,strength
R3455	T11530	T11512	punct	", ",showed
R3456	T11531	T11512	cc	and,showed
R3457	T11532	T11512	conj	exhibited,showed
R3458	T11533	T11534	det	no,changes
R3459	T11534	T11532	dobj	changes,exhibited
R346	T2341	T2340	amod	possible,redundancy
R3460	T11535	T11534	amod	apparent,changes
R3461	T11536	T11537	amod	anatomical,histological
R3462	T11537	T11534	amod	histological,changes
R3463	T11538	T11537	punct	-,histological
R3464	T11539	T11502	punct	.,survived
R3465	T11541	T11542	advmod	However,impaired
R3466	T11543	T11542	punct	", ",impaired
R3467	T11544	T11545	npadvmod	hippocampus,dependent
R3468	T11545	T11547	amod	dependent,learning
R3469	T11546	T11545	punct	-,dependent
R347	T2342	T2340	amod	functional,redundancy
R3470	T11547	T11542	nsubjpass	learning,impaired
R3471	T11548	T11547	amod	spatial,learning
R3472	T11549	T11547	cc	and,learning
R3473	T11550	T11551	npadvmod	cerebellum,dependent
R3474	T11551	T11553	amod	dependent,coordination
R3475	T11552	T11551	punct	-,dependent
R3476	T11553	T11547	conj	coordination,learning
R3477	T11554	T11553	compound	motor,coordination
R3478	T11555	T11547	prep	in,learning
R3479	T11556	T11557	npadvmod	ADAM11,deficient
R348	T2343	T2340	prep	with,redundancy
R3480	T11557	T11559	amod	deficient,mice
R3481	T11558	T11557	punct	-,deficient
R3482	T11559	T11555	pobj	mice,in
R3483	T11560	T11542	auxpass	were,impaired
R3484	T11561	T11562	advmod	when,tested
R3485	T11562	T11542	advcl	tested,impaired
R3486	T11563	T11562	advcl	using,tested
R3487	T11564	T11565	nmod	water,maze
R3488	T11565	T11566	nmod	maze,tasks
R3489	T11566	T11563	dobj	tasks,using
R349	T2344	T2345	amod	other,protease
R3490	T11567	T11565	cc	and,maze
R3491	T11568	T11569	amod	rotating,rod
R3492	T11569	T11565	conj	rod,maze
R3493	T11570	T11542	punct	.,impaired
R3494	T11572	T11573	poss	Our,strain
R3495	T11573	T11577	nsubj	strain,has
R3496	T11574	T11575	advmod	genetically,modified
R3497	T11575	T11573	amod	modified,strain
R3498	T11576	T11573	compound	mouse,strain
R3499	T11578	T11579	det	the,potential
R35	T607	T605	attr	molecule,be
R350	T2345	T2343	pobj	protease,with
R3500	T11579	T11577	dobj	potential,has
R3501	T11580	T11581	aux	to,be
R3502	T11581	T11579	acl	be,potential
R3503	T11582	T11583	det	a,tools
R3504	T11583	T11581	attr	tools,be
R3505	T11584	T11583	amod	useful,tools
R3506	T11585	T11584	cc	and,useful
R3507	T11586	T11584	conj	sensitive,useful
R3508	T11587	T11583	prep	for,tools
R3509	T11588	T11589	amod	detailed,investigation
R351	T2346	T2347	punct	[,7
R3510	T11589	T11587	pobj	investigation,for
R3511	T11590	T11589	prep	of,investigation
R3512	T11591	T11592	compound	ADAM,proteins
R3513	T11592	T11593	poss	proteins,functions
R3514	T11593	T11590	pobj	functions,of
R3515	T11594	T11592	case	',proteins
R3516	T11595	T11593	prep	in,functions
R3517	T11596	T11597	det	the,system
R3518	T11597	T11595	pobj	system,in
R3519	T11598	T11597	amod	nervous,system
R352	T2347	T2338	parataxis	7,suggesting
R3520	T11599	T11577	punct	.,has
R3521	T11865	T11864	prep	of,Construction
R3522	T11866	T11867	det	an,vector
R3523	T11867	T11865	pobj	vector,of
R3524	T11868	T11867	nmod	Adam11,vector
R3525	T11869	T11867	nmod	gene,vector
R3526	T11870	T11869	punct	-,gene
R3527	T11871	T11869	amod	targeting,gene
R3528	T11873	T11874	det	The,fragment
R3529	T11874	T11880	nsubjpass	fragment,amplified
R353	T2348	T2349	punct	-,10
R3530	T11875	T11876	nummod	13.7,kb
R3531	T11876	T11874	compound	kb,fragment
R3532	T11877	T11876	punct	-,kb
R3533	T11878	T11874	compound	BamHI,fragment
R3534	T11879	T11874	compound	DNA,fragment
R3535	T11881	T11874	acl	covering,fragment
R3536	T11882	T11883	nmod	exons,2
R3537	T11883	T11881	dobj	2,covering
R3538	T11884	T11885	punct	–,20
R3539	T11885	T11883	prep	20,2
R354	T2349	T2347	prep	10,7
R3540	T11886	T11883	prep	of,2
R3541	T11887	T11888	det	the,gene
R3542	T11888	T11886	pobj	gene,of
R3543	T11889	T11888	compound	Adam11,gene
R3544	T11890	T11880	auxpass	was,amplified
R3545	T11891	T11880	prep	from,amplified
R3546	T11892	T11893	nmod	C57BL,DNA
R3547	T11893	T11891	pobj	DNA,from
R3548	T11894	T11892	punct	/,C57BL
R3549	T11895	T11892	nummod	6,C57BL
R355	T2350	T2347	punct	],7
R3550	T11896	T11893	amod	genomic,DNA
R3551	T11897	T11880	prep	by,amplified
R3552	T11898	T11899	det	the,PCR
R3553	T11899	T11897	pobj	PCR,by
R3554	T11900	T11899	acl	using,PCR
R3555	T11901	T11902	compound	Expand,mix
R3556	T11902	T11900	dobj	mix,using
R3557	T11903	T11904	compound	Hi,Fidelity
R3558	T11904	T11902	compound	Fidelity,mix
R3559	T11905	T11904	punct	-,Fidelity
R356	T2351	T2320	punct	.,are
R3560	T11906	T11902	compound	polymerase,mix
R3561	T11907	T11908	punct	(,KK
R3562	T11908	T11902	parataxis	KK,mix
R3563	T11909	T11908	compound	Roche,KK
R3564	T11910	T11908	compound	Diagnostics,KK
R3565	T11911	T11908	punct	", ",KK
R3566	T11912	T11908	npadvmod	Tokyo,KK
R3567	T11913	T11908	punct	", ",KK
R3568	T11914	T11908	npadvmod	Japan,KK
R3569	T11915	T11908	punct	),KK
R357	T2353	T2354	det	The,half
R3570	T11916	T11880	punct	.,amplified
R3571	T11918	T11919	aux	To,generate
R3572	T11919	T11920	advcl	generate,inserted
R3573	T11921	T11922	det	a,mutation
R3574	T11922	T11919	dobj	mutation,generate
R3575	T11923	T11919	prep	in,generate
R3576	T11924	T11925	det	the,gene
R3577	T11925	T11923	pobj	gene,in
R3578	T11926	T11925	compound	mouse,gene
R3579	T11927	T11925	compound	Adam11,gene
R358	T2354	T2356	nsubjpass	half,thought
R3580	T11928	T11920	punct	", ",inserted
R3581	T11929	T11920	nsubj	we,inserted
R3582	T11930	T11931	det	a,cassette
R3583	T11931	T11920	dobj	cassette,inserted
R3584	T11932	T11931	compound	PGKneo,cassette
R3585	T11933	T11920	prep	into,inserted
R3586	T11934	T11935	nmod	exons,5
R3587	T11935	T11933	pobj	5,into
R3588	T11936	T11937	punct	–,7
R3589	T11937	T11935	prep	7,5
R359	T2355	T2354	amod	remaining,half
R3590	T11938	T11935	prep	of,5
R3591	T11939	T11940	det	the,gene
R3592	T11940	T11938	pobj	gene,of
R3593	T11941	T11940	compound	Adam11,gene
R3594	T11942	T11920	punct	.,inserted
R3595	T11944	T11945	det	The,construct
R3596	T11945	T11948	nsubj	construct,consisted
R3597	T11946	T11945	amod	final,construct
R3598	T11947	T11945	compound	targeting,construct
R3599	T11949	T11948	prep	of,consisted
R36	T608	T607	compound	adhesion,molecule
R360	T2357	T2354	punct	", ",half
R3600	T11950	T11951	det	a,fragment
R3601	T11951	T11949	pobj	fragment,of
R3602	T11952	T11953	nummod	10.1,kb
R3603	T11953	T11951	nmod	kb,fragment
R3604	T11954	T11953	punct	-,kb
R3605	T11955	T11951	amod	genomic,fragment
R3606	T11956	T11951	compound	DNA,fragment
R3607	T11957	T11958	dep	that,interrupted
R3608	T11958	T11951	relcl	interrupted,fragment
R3609	T11959	T11958	auxpass	was,interrupted
R361	T2358	T2359	dep	which,are
R3610	T11960	T11958	agent	by,interrupted
R3611	T11961	T11962	det	the,insertion
R3612	T11962	T11960	pobj	insertion,by
R3613	T11963	T11962	prep	of,insertion
R3614	T11964	T11965	det	the,cassette
R3615	T11965	T11963	pobj	cassette,of
R3616	T11966	T11965	compound	PGKneo,cassette
R3617	T11967	T11958	cc	and,interrupted
R3618	T11968	T11958	conj	contained,interrupted
R3619	T11969	T11970	det	a,cassette
R362	T2359	T2354	relcl	are,half
R3620	T11970	T11968	dobj	cassette,contained
R3621	T11971	T11972	compound	MC1,TK
R3622	T11972	T11970	compound	TK,cassette
R3623	T11973	T11972	punct	/,TK
R3624	T11974	T11968	prep	as,contained
R3625	T11975	T11976	det	a,marker
R3626	T11976	T11974	pobj	marker,as
R3627	T11977	T11978	amod	negative,selection
R3628	T11978	T11976	compound	selection,marker
R3629	T11979	T11976	prep	against,marker
R363	T2360	T2361	amod	non-protease,ADAMs
R3630	T11980	T11981	amod	random,integration
R3631	T11981	T11979	pobj	integration,against
R3632	T11982	T11983	punct	[,39
R3633	T11983	T11968	parataxis	39,contained
R3634	T11984	T11983	punct	],39
R3635	T11985	T11948	punct	.,consisted
R364	T2361	T2359	attr	ADAMs,are
R3640	T12310	T12309	prep	of,Generation
R3641	T12311	T12312	npadvmod	Adam11,deficient
R3642	T12312	T12313	amod	deficient,mice
R3643	T12313	T12310	pobj	mice,of
R3644	T12315	T12316	det	The,vector
R3645	T12316	T12319	nsubjpass	vector,electroporated
R3646	T12317	T12316	amod	linearised,vector
R3647	T12318	T12316	compound	targeting,vector
R3648	T12320	T12319	auxpass	was,electroporated
R3649	T12321	T12319	prep	into,electroporated
R365	T2362	T2361	punct	-,ADAMs
R3650	T12322	T12323	nmod	TT2,cells
R3651	T12323	T12321	pobj	cells,into
R3652	T12324	T12325	amod	embryonic,stem
R3653	T12325	T12323	nmod	stem,cells
R3654	T12326	T12325	punct	(,stem
R3655	T12327	T12325	appos	ES,stem
R3656	T12328	T12323	punct	),cells
R3657	T12329	T12330	punct	[,40
R3658	T12330	T12319	parataxis	40,electroporated
R3659	T12331	T12330	punct	],40
R366	T2363	T2356	punct	", ",thought
R3660	T12332	T12319	punct	.,electroporated
R3661	T12334	T12335	amod	Homologous,recombinants
R3662	T12335	T12336	nsubjpass	recombinants,selected
R3663	T12337	T12336	auxpass	were,selected
R3664	T12338	T12336	prep	by,selected
R3665	T12339	T12338	pobj	PCR,by
R3666	T12340	T12336	advcl	using,selected
R3667	T12341	T12342	det	the,primers
R3668	T12342	T12340	dobj	primers,using
R3669	T12343	T12342	amod	following,primers
R367	T2364	T2356	auxpass	are,thought
R3670	T12344	T12342	punct	", ",primers
R3671	T12345	T12342	appos	AGN1,primers
R3672	T12346	T12345	punct	: ,AGN1
R3673	T12347	T12345	appos	5,AGN1
R3674	T12348	T12347	punct	',5
R3675	T12349	T12347	punct	-,5
R3676	T12350	T12347	appos	TCGTGCTTTACGGTATCGCCGCTCCCGATT,5
R3677	T12351	T12347	punct	-,5
R3678	T12352	T12347	nummod	3,5
R3679	T12353	T12347	punct	',5
R368	T2365	T2366	aux	to,be
R3680	T12354	T12345	prep	in,AGN1
R3681	T12355	T12356	det	the,cassette
R3682	T12356	T12354	pobj	cassette,in
R3683	T12357	T12356	compound	PGKneo,cassette
R3684	T12358	T12342	punct	", ",primers
R3685	T12359	T12342	cc	and,primers
R3686	T12360	T12342	conj	SGN033,primers
R3687	T12361	T12360	punct	: ,SGN033
R3688	T12362	T12360	appos	5,SGN033
R3689	T12363	T12362	punct	',5
R369	T2366	T2356	xcomp	be,thought
R3690	T12364	T12362	punct	-,5
R3691	T12365	T12362	appos	GGACCCGGAAGACATTTGCACGGT,5
R3692	T12366	T12362	punct	-,5
R3693	T12367	T12362	nummod	3,5
R3694	T12368	T12362	punct	',5
R3695	T12369	T12360	prep	outside,SGN033
R3696	T12370	T12371	det	the,vector
R3697	T12371	T12369	pobj	vector,outside
R3698	T12372	T12371	compound	targeting,vector
R3699	T12373	T12336	punct	.,selected
R37	T609	T602	punct	", ",thought
R370	T2367	T2368	compound	adhesion,molecules
R3700	T12375	T12376	amod	Homologous,DNA
R3701	T12376	T12378	nsubjpass	DNA,amplified
R3702	T12377	T12376	amod	recombined,DNA
R3703	T12379	T12378	auxpass	was,amplified
R3704	T12380	T12378	advmod	efficiently,amplified
R3705	T12381	T12378	agent	by,amplified
R3706	T12382	T12383	nummod	35,cycles
R3707	T12383	T12381	pobj	cycles,by
R3708	T12384	T12383	prep	of,cycles
R3709	T12385	T12386	det	the,steps
R371	T2368	T2366	attr	molecules,be
R3710	T12386	T12384	pobj	steps,of
R3711	T12387	T12386	amod	following,steps
R3712	T12388	T12386	compound	amplification,steps
R3713	T12389	T12386	punct	(,steps
R3714	T12390	T12391	nummod	94,°C
R3715	T12391	T12386	appos	°C,steps
R3716	T12392	T12391	punct	-,°C
R3717	T12393	T12394	nummod	30,sec
R3718	T12394	T12391	npadvmod	sec,°C
R3719	T12395	T12391	cc	and,°C
R372	T2369	T2356	punct	.,thought
R3720	T12396	T12397	nummod	68,°C
R3721	T12397	T12391	conj	°C,°C
R3722	T12398	T12397	punct	-,°C
R3723	T12399	T12400	nummod	5,min
R3724	T12400	T12397	npadvmod	min,°C
R3725	T12401	T12386	punct	),steps
R3726	T12402	T12378	punct	.,amplified
R3727	T12404	T12405	advmod	Correctly,targeted
R3728	T12405	T12406	amod	targeted,clones
R3729	T12406	T12408	nsubjpass	clones,injected
R373	T2371	T2372	amod	More,ten
R3730	T12407	T12406	compound	ES,clones
R3731	T12409	T12408	auxpass	were,injected
R3732	T12410	T12408	prep	into,injected
R3733	T12411	T12412	amod	fertilised,eggs
R3734	T12412	T12410	pobj	eggs,into
R3735	T12413	T12412	compound	ICR,eggs
R3736	T12414	T12412	compound	mouse,eggs
R3737	T12415	T12408	prep	at,injected
R3738	T12416	T12417	det	the,stage
R3739	T12417	T12415	pobj	stage,at
R374	T2372	T2374	nummod	ten,ADAMs
R3740	T12418	T12419	nummod	eight,cell
R3741	T12419	T12417	compound	cell,stage
R3742	T12420	T12419	punct	-,cell
R3743	T12421	T12408	punct	.,injected
R3744	T12423	T12424	det	The,chimeras
R3745	T12424	T12427	nsubjpass	chimeras,mated
R3746	T12425	T12424	amod	resulting,chimeras
R3747	T12426	T12424	amod	male,chimeras
R3748	T12428	T12427	auxpass	were,mated
R3749	T12429	T12427	prep	with,mated
R375	T2373	T2372	quantmod	than,ten
R3750	T12430	T12431	compound	C57BL,6NCrj
R3751	T12431	T12433	compound	6NCrj,females
R3752	T12432	T12431	punct	/,6NCrj
R3753	T12433	T12429	pobj	females,with
R3754	T12434	T12435	punct	(,Japan
R3755	T12435	T12427	parataxis	Japan,mated
R3756	T12436	T12435	compound	Charles,Japan
R3757	T12437	T12435	compound	River,Japan
R3758	T12438	T12435	punct	", ",Japan
R3759	T12439	T12435	npadvmod	Tokyo,Japan
R376	T2374	T2375	nsubjpass	ADAMs,shown
R3760	T12440	T12435	punct	", ",Japan
R3761	T12441	T12435	npadvmod	Japan,Japan
R3762	T12442	T12435	punct	),Japan
R3763	T12443	T12427	punct	", ",mated
R3764	T12444	T12427	cc	and,mated
R3765	T12445	T12446	amod	resulting,mice
R3766	T12446	T12456	nsubjpass	mice,interbred
R3767	T12447	T12446	amod	heterozygous,mice
R3768	T12448	T12446	punct	(,mice
R3769	T12449	T12450	punct	+,-
R377	T2376	T2375	aux	have,shown
R3770	T12450	T12446	punct	-,mice
R3771	T12451	T12450	punct	/,-
R3772	T12452	T12446	punct	),mice
R3773	T12453	T12446	amod	male,mice
R3774	T12454	T12453	cc	and,male
R3775	T12455	T12453	conj	female,male
R3776	T12456	T12427	conj	interbred,mated
R3777	T12457	T12456	auxpass	were,interbred
R3778	T12458	T12459	aux	to,generate
R3779	T12459	T12456	advcl	generate,interbred
R378	T2377	T2375	auxpass	been,shown
R3780	T12460	T12461	amod	homozygous,mice
R3781	T12461	T12459	dobj	mice,generate
R3782	T12462	T12461	punct	(,mice
R3783	T12463	T12464	punct	-,-
R3784	T12464	T12461	punct	-,mice
R3785	T12465	T12464	punct	/,-
R3786	T12466	T12461	punct	),mice
R3787	T12467	T12456	punct	.,interbred
R3788	T12588	T12589	compound	Southern,blot
R3789	T12589	T12590	compound	blot,analysis
R379	T2378	T2379	aux	to,support
R3790	T12592	T12593	nmod	Mouse,DNA
R3791	T12593	T12595	nsubjpass	DNA,extracted
R3792	T12594	T12593	amod	genomic,DNA
R3793	T12596	T12593	acl	used,DNA
R3794	T12597	T12596	prep	for,used
R3795	T12598	T12599	compound	Southern,blot
R3796	T12599	T12600	compound	blot,analysis
R3797	T12600	T12597	pobj	analysis,for
R3798	T12601	T12595	auxpass	was,extracted
R3799	T12602	T12595	prep	from,extracted
R38	T610	T611	mark	since,has
R380	T2379	T2375	xcomp	support,shown
R3800	T12603	T12604	det	the,liver
R3801	T12604	T12602	pobj	liver,from
R3802	T12605	T12604	prep	of,liver
R3803	T12606	T12607	det	each,genotype
R3804	T12607	T12605	pobj	genotype,of
R3805	T12608	T12595	punct	.,extracted
R3806	T12610	T12611	npadvmod	BamHI,digested
R3807	T12611	T12613	amod	digested,DNA
R3808	T12612	T12611	punct	-,digested
R3809	T12613	T12615	nsubjpass	DNA,probed
R381	T2380	T2381	npadvmod	integrin,mediated
R3810	T12614	T12613	amod	genomic,DNA
R3811	T12616	T12615	auxpass	was,probed
R3812	T12617	T12615	prep	with,probed
R3813	T12618	T12619	det	the,probe
R3814	T12619	T12617	pobj	probe,with
R3815	T12620	T12619	punct	[,probe
R3816	T12621	T12622	npadvmod	32P,labelled
R3817	T12622	T12619	amod	labelled,probe
R3818	T12623	T12622	punct	],labelled
R3819	T12624	T12622	punct	-,labelled
R382	T2381	T2383	amod	mediated,adhesion
R3820	T12625	T12619	compound	BE2K,probe
R3821	T12626	T12619	punct	", ",probe
R3822	T12627	T12628	dep	which,was
R3823	T12628	T12619	relcl	was,probe
R3824	T12629	T12630	det	a,fragment
R3825	T12630	T12628	attr	fragment,was
R3826	T12631	T12632	nummod	2.0,kb
R3827	T12632	T12630	nmod	kb,fragment
R3828	T12633	T12632	punct	-,kb
R3829	T12634	T12635	nmod	BamHI,EcoRI
R383	T2382	T2381	punct	-,mediated
R3830	T12635	T12630	nmod	EcoRI,fragment
R3831	T12636	T12635	punct	–,EcoRI
R3832	T12637	T12630	amod	genomic,fragment
R3833	T12638	T12630	acl	located,fragment
R3834	T12639	T12638	prep	in,located
R3835	T12640	T12639	pobj	intron,in
R3836	T12641	T12640	nummod	2,intron
R3837	T12642	T12615	punct	.,probed
R3838	T13011	T13012	compound	Western,blot
R3839	T13012	T13013	compound	blot,analysis
R384	T2383	T2379	dobj	adhesion,support
R3840	T13015	T13016	det	The,absence
R3841	T13016	T13017	nsubjpass	absence,confirmed
R3842	T13018	T13016	prep	of,absence
R3843	T13019	T13020	compound	ADAM11,protein
R3844	T13020	T13018	pobj	protein,of
R3845	T13021	T13016	prep	in,absence
R3846	T13022	T13023	det	the,mice
R3847	T13023	T13021	pobj	mice,in
R3848	T13024	T13023	punct	(,mice
R3849	T13025	T13026	punct	-,-
R385	T2384	T2383	compound	cell,adhesion
R3850	T13026	T13023	punct	-,mice
R3851	T13027	T13026	punct	/,-
R3852	T13028	T13023	punct	),mice
R3853	T13029	T13017	auxpass	was,confirmed
R3854	T13030	T13017	agent	by,confirmed
R3855	T13031	T13032	compound	Western,blot
R3856	T13032	T13033	compound	blot,analysis
R3857	T13033	T13030	pobj	analysis,by
R3858	T13034	T13017	punct	.,confirmed
R3859	T13036	T13037	aux	To,be
R386	T2385	T2386	advmod	in,vitro
R3860	T13037	T13038	advcl	be,isolated
R3861	T13039	T13037	acomp	brief,be
R3862	T13040	T13038	punct	", ",isolated
R3863	T13041	T13042	det	the,cerebellum
R3864	T13042	T13038	nsubjpass	cerebellum,isolated
R3865	T13043	T13038	auxpass	was,isolated
R3866	T13044	T13038	prep	from,isolated
R3867	T13045	T13046	det	a,mouse
R3868	T13046	T13044	pobj	mouse,from
R3869	T13047	T13048	nummod	six,month
R387	T2386	T2379	advmod	vitro,support
R3870	T13048	T13049	npadvmod	month,old
R3871	T13049	T13046	amod	old,mouse
R3872	T13050	T13049	punct	-,old
R3873	T13051	T13046	prep	of,mouse
R3874	T13052	T13053	det	each,genotype
R3875	T13053	T13051	pobj	genotype,of
R3876	T13054	T13038	cc	and,isolated
R3877	T13055	T13038	conj	homogenised,isolated
R3878	T13056	T13055	prep	in,homogenised
R3879	T13057	T13058	compound	cell,lysis
R388	T2387	T2388	punct	[,11
R3880	T13058	T13059	compound	lysis,buffer
R3881	T13059	T13056	pobj	buffer,in
R3882	T13060	T13061	punct	(,cocktail
R3883	T13061	T13055	parataxis	cocktail,homogenised
R3884	T13062	T13063	nummod	50,mM
R3885	T13063	T13064	compound	mM,HCl
R3886	T13064	T13061	dep	HCl,cocktail
R3887	T13065	T13064	compound	Tris,HCl
R3888	T13066	T13064	punct	-,HCl
R3889	T13067	T13061	punct	", ",cocktail
R389	T2388	T2375	parataxis	11,shown
R3890	T13068	T13061	dep	pH,cocktail
R3891	T13069	T13068	nummod	7.5,pH
R3892	T13070	T13061	punct	", ",cocktail
R3893	T13071	T13072	nummod	100,mM
R3894	T13072	T13073	compound	mM,NaCl
R3895	T13073	T13061	dep	NaCl,cocktail
R3896	T13074	T13061	punct	", ",cocktail
R3897	T13075	T13076	nummod	1,%
R3898	T13076	T13077	compound	%,NP
R3899	T13077	T13061	dep	NP,cocktail
R39	T611	T602	advcl	has,thought
R390	T2389	T2388	punct	],11
R3900	T13078	T13077	punct	-,NP
R3901	T13079	T13077	nummod	40,NP
R3902	T13080	T13061	punct	", ",cocktail
R3903	T13081	T13082	compound	protease,inhibitor
R3904	T13082	T13061	compound	inhibitor,cocktail
R3905	T13083	T13084	punct	[,Diagnostics
R3906	T13084	T13061	parataxis	Diagnostics,cocktail
R3907	T13085	T13084	compound	Roche,Diagnostics
R3908	T13086	T13084	punct	],Diagnostics
R3909	T13087	T13061	punct	),cocktail
R391	T2390	T2375	punct	.,shown
R3910	T13088	T13038	punct	.,isolated
R3911	T13090	T13091	prep	After,concentrated
R3912	T13092	T13090	pobj	removal,After
R3913	T13093	T13092	prep	of,removal
R3914	T13094	T13095	compound	cell,debris
R3915	T13095	T13093	pobj	debris,of
R3916	T13096	T13092	prep	by,removal
R3917	T13097	T13096	pobj	centrifugation,by
R3918	T13098	T13091	punct	", ",concentrated
R3919	T13099	T13100	det	the,proteins
R392	T2392	T2393	advmod	More,recently
R3920	T13100	T13091	nsubjpass	proteins,concentrated
R3921	T13101	T13100	amod	glycosylated,proteins
R3922	T13102	T13100	prep	in,proteins
R3923	T13103	T13104	det	the,supernatant
R3924	T13104	T13102	pobj	supernatant,in
R3925	T13105	T13091	auxpass	were,concentrated
R3926	T13106	T13091	prep	by,concentrated
R3927	T13107	T13108	det	the,chromatography
R3928	T13108	T13106	pobj	chromatography,by
R3929	T13109	T13108	compound	affinity,chromatography
R393	T2393	T2394	advmod	recently,reported
R3930	T13110	T13091	advcl	using,concentrated
R3931	T13111	T13112	compound	Con,4B
R3932	T13112	T13110	dobj	4B,using
R3933	T13113	T13112	compound	A,4B
R3934	T13114	T13112	compound	Sepharose,4B
R3935	T13115	T13116	punct	(,Corp.
R3936	T13116	T13110	parataxis	Corp.,using
R3937	T13117	T13116	compound	Amersham,Corp.
R3938	T13118	T13116	compound	Biosciences,Corp.
R3939	T13119	T13116	punct	),Corp.
R394	T2395	T2394	punct	", ",reported
R3940	T13120	T13091	punct	.,concentrated
R3941	T13122	T13123	det	Each,sample
R3942	T13123	T13124	nsubjpass	sample,separated
R3943	T13125	T13124	auxpass	was,separated
R3944	T13126	T13124	prep	on,separated
R3945	T13127	T13128	nummod	10,%
R3946	T13128	T13129	compound	%,PAGE
R3947	T13129	T13126	pobj	PAGE,on
R3948	T13130	T13129	compound	SDS,PAGE
R3949	T13131	T13129	punct	-,PAGE
R395	T2396	T2397	det	the,finding
R3950	T13132	T13124	punct	", ",separated
R3951	T13133	T13124	cc	and,separated
R3952	T13134	T13124	conj	transferred,separated
R3953	T13135	T13134	prep	to,transferred
R3954	T13136	T13137	det	a,membrane
R3955	T13137	T13135	pobj	membrane,to
R3956	T13138	T13137	compound	PVDF,membrane
R3957	T13139	T13124	punct	.,separated
R3958	T13141	T13142	det	The,blot
R3959	T13142	T13143	nsubjpass	blot,incubated
R396	T2397	T2394	nsubjpass	finding,reported
R3960	T13144	T13143	auxpass	was,incubated
R3961	T13145	T13143	advmod	then,incubated
R3962	T13146	T13143	prep	with,incubated
R3963	T13147	T13148	amod	monoclonal,antibody
R3964	T13148	T13146	pobj	antibody,with
R3965	T13149	T13148	prep	against,antibody
R3966	T13150	T13151	det	the,ADAM11
R3967	T13151	T13149	pobj	ADAM11,against
R3968	T13152	T13153	punct	(,Patent
R3969	T13153	T13151	parataxis	Patent,ADAM11
R397	T2398	T2394	aux	has,reported
R3970	T13154	T13155	compound	U.,S.
R3971	T13155	T13153	compound	S.,Patent
R3972	T13156	T13153	nummod	"5,631,351",Patent
R3973	T13157	T13153	punct	),Patent
R3974	T13158	T13148	prep	at,antibody
R3975	T13159	T13160	nummod	1,μg
R3976	T13160	T13158	pobj	μg,at
R3977	T13161	T13162	punct	/,ml
R3978	T13162	T13160	prep	ml,μg
R3979	T13163	T13143	punct	.,incubated
R398	T2399	T2394	auxpass	been,reported
R3980	T13165	T13166	amod	Bound,antibodies
R3981	T13166	T13167	nsubjpass	antibodies,visualised
R3982	T13168	T13167	auxpass	were,visualised
R3983	T13169	T13167	prep	with,visualised
R3984	T13170	T13171	compound	horseradish,peroxidase
R3985	T13171	T13172	npadvmod	peroxidase,labelled
R3986	T13172	T13174	amod	labelled,antibody
R3987	T13173	T13172	punct	-,labelled
R3988	T13174	T13169	pobj	antibody,with
R3989	T13175	T13174	amod	second,antibody
R399	T2400	T2401	mark	that,controlled
R3990	T13176	T13174	cc	and,antibody
R3991	T13177	T13178	det	an,system
R3992	T13178	T13174	conj	system,antibody
R3993	T13179	T13180	compound	ECL,plus
R3994	T13180	T13178	compound	plus,system
R3995	T13181	T13180	punct	-,plus
R3996	T13182	T13183	compound	chemiluminescence,detection
R3997	T13183	T13178	compound	detection,system
R3998	T13184	T13185	punct	(,Corp.
R3999	T13185	T13167	parataxis	Corp.,visualised
R4	T568	T569	amod	spatial,learning
R40	T612	T611	nsubj	it,has
R400	T2401	T2394	ccomp	controlled,reported
R4000	T13186	T13185	compound	Amersham,Corp.
R4001	T13187	T13185	compound	Biosciences,Corp.
R4002	T13188	T13185	punct	),Corp.
R4003	T13189	T13167	punct	.,visualised
R4004	T13416	T13417	amod	Behavioural,analysis
R4005	T13419	T13420	det	All,procedures
R4006	T13420	T13422	nsubj	procedures,conformed
R4007	T13421	T13420	compound	animal,procedures
R4008	T13423	T13422	prep	to,conformed
R4009	T13424	T13425	det	the,regulations
R401	T2402	T2403	npadvmod	integrin,mediated
R4010	T13425	T13423	pobj	regulations,to
R4011	T13426	T13425	amod	Japanese,regulations
R4012	T13427	T13425	prep	on,regulations
R4013	T13428	T13429	compound	animal,care
R4014	T13429	T13427	pobj	care,on
R4015	T13430	T13429	cc	and,care
R4016	T13431	T13429	conj	use,care
R4017	T13432	T13425	punct	", ",regulations
R4018	T13433	T13425	prep	following,regulations
R4019	T13434	T13435	det	the,Guideline
R402	T2403	T2405	amod	mediated,migration
R4020	T13435	T13433	pobj	Guideline,following
R4021	T13436	T13435	prep	for,Guideline
R4022	T13437	T13438	compound	Animal,Experimentation
R4023	T13438	T13436	pobj	Experimentation,for
R4024	T13439	T13435	prep	of,Guideline
R4025	T13440	T13441	det	the,Association
R4026	T13441	T13439	pobj	Association,of
R4027	T13442	T13441	compound	Japanese,Association
R4028	T13443	T13441	prep	for,Association
R4029	T13444	T13443	pobj	Laboratory,for
R403	T2404	T2403	punct	-,mediated
R4030	T13445	T13444	prep	of,Laboratory
R4031	T13446	T13447	compound	Animal,Science
R4032	T13447	T13445	pobj	Science,of
R4033	T13448	T13422	punct	", ",conformed
R4034	T13449	T13422	cc	and,conformed
R4035	T13450	T13451	auxpass	were,approved
R4036	T13451	T13422	conj	approved,conformed
R4037	T13452	T13451	agent	by,approved
R4038	T13453	T13454	det	the,Committee
R4039	T13454	T13452	pobj	Committee,by
R404	T2405	T2401	nsubjpass	migration,controlled
R4040	T13455	T13456	nmod	Animal,Care
R4041	T13456	T13454	nmod	Care,Committee
R4042	T13457	T13456	cc	and,Care
R4043	T13458	T13456	conj	Use,Care
R4044	T13459	T13454	prep	of,Committee
R4045	T13460	T13461	compound	Eisai,Co.
R4046	T13461	T13459	pobj	Co.,of
R4047	T13462	T13461	punct	", ",Co.
R4048	T13463	T13461	amod	Ltd,Co.
R4049	T13464	T13422	punct	.,conformed
R405	T2406	T2405	compound	cell,migration
R4050	T13466	T13467	prep	For,used
R4051	T13468	T13469	det	the,experiments
R4052	T13469	T13466	pobj	experiments,For
R4053	T13470	T13469	amod	present,experiments
R4054	T13471	T13467	punct	", ",used
R4055	T13472	T13473	npadvmod	ADAM11,deficient
R4056	T13473	T13475	amod	deficient,mice
R4057	T13474	T13473	punct	-,deficient
R4058	T13475	T13467	nsubjpass	mice,used
R4059	T13476	T13475	amod	male,mice
R406	T2407	T2405	prep	of,migration
R4060	T13477	T13478	punct	(,generations
R4061	T13478	T13475	parataxis	generations,mice
R4062	T13479	T13478	amod	backcrossed,generations
R4063	T13480	T13478	prep	into,generations
R4064	T13481	T13482	compound	C57BL,6NCrj
R4065	T13482	T13480	pobj	6NCrj,into
R4066	T13483	T13482	punct	/,6NCrj
R4067	T13484	T13478	punct	", ",generations
R4068	T13485	T13486	nsubj	n,14
R4069	T13486	T13478	ccomp	14,generations
R407	T2408	T2409	compound	tissue,culture
R4070	T13487	T13486	punct	=,14
R4071	T13488	T13478	punct	),generations
R4072	T13489	T13467	auxpass	were,used
R4073	T13490	T13467	prep	in,used
R4074	T13491	T13492	det	all,analyses
R4075	T13492	T13490	pobj	analyses,in
R4076	T13493	T13492	amod	behavioural,analyses
R4077	T13494	T13495	punct	(,weeks
R4078	T13495	T13467	parataxis	weeks,used
R4079	T13496	T13497	quantmod	22,24
R408	T2409	T2410	compound	culture,cells
R4080	T13497	T13495	nummod	24,weeks
R4081	T13498	T13497	punct	–,24
R4082	T13499	T13495	prep	of,weeks
R4083	T13500	T13499	pobj	age,of
R4084	T13501	T13495	punct	),weeks
R4085	T13502	T13467	punct	.,used
R4086	T13504	T13505	nsubjpass	All,conducted
R4087	T13506	T13504	prep	of,All
R4088	T13507	T13508	det	the,studies
R4089	T13508	T13506	pobj	studies,of
R409	T2410	T2407	pobj	cells,of
R4090	T13509	T13508	amod	behavioural,studies
R4091	T13510	T13505	auxpass	were,conducted
R4092	T13511	T13505	prep	between,conducted
R4093	T13512	T13513	nummod	10,00
R4094	T13513	T13511	pobj	00,between
R4095	T13514	T13513	punct	:,00
R4096	T13515	T13513	cc	and,00
R4097	T13516	T13517	nummod	16,00
R4098	T13517	T13513	conj	00,00
R4099	T13518	T13517	punct	:,00
R41	T613	T614	det	a,domain
R410	T2411	T2401	aux	can,controlled
R4100	T13519	T13505	agent	by,conducted
R4101	T13520	T13521	det	a,experimenter
R4102	T13521	T13519	pobj	experimenter,by
R4103	T13522	T13523	advmod	well,trained
R4104	T13523	T13521	amod	trained,experimenter
R4105	T13524	T13523	punct	-,trained
R4106	T13525	T13521	amod	blind,experimenter
R4107	T13526	T13525	prep	to,blind
R4108	T13527	T13528	det	the,genotypes
R4109	T13528	T13526	pobj	genotypes,to
R411	T2412	T2401	auxpass	be,controlled
R4110	T13529	T13528	compound	mouse,genotypes
R4111	T13530	T13505	punct	.,conducted
R4112	T13661	T13662	amod	Spontaneous,activity
R4113	T13663	T13662	compound	motor,activity
R4114	T13665	T13666	compound	Locomotor,activity
R4115	T13666	T13667	nsubjpass	activity,measured
R4116	T13668	T13666	prep	in,activity
R4117	T13669	T13670	det	a,environment
R4118	T13670	T13668	pobj	environment,in
R4119	T13671	T13670	amod	novel,environment
R412	T2413	T2401	agent	by,controlled
R4120	T13672	T13667	auxpass	was,measured
R4121	T13673	T13667	prep	by,measured
R4122	T13674	T13673	pcomp	introducing,by
R4123	T13675	T13674	dobj	mice,introducing
R4124	T13676	T13677	punct	(,+
R4125	T13677	T13674	punct	+,introducing
R4126	T13678	T13677	punct	+,+
R4127	T13679	T13677	punct	/,+
R4128	T13680	T13677	punct	", ",+
R4129	T13681	T13682	punct	+,-
R413	T2414	T2415	amod	distinct,ADAMs
R4130	T13682	T13677	conj	-,+
R4131	T13683	T13682	punct	/,-
R4132	T13684	T13682	cc	and,-
R4133	T13685	T13686	punct	-,-
R4134	T13686	T13682	conj	-,-
R4135	T13687	T13686	punct	/,-
R4136	T13688	T13677	punct	;,+
R4137	T13689	T13690	nsubj	n,8
R4138	T13690	T13677	ccomp	8,+
R4139	T13691	T13690	punct	=,8
R414	T2415	T2413	pobj	ADAMs,by
R4140	T13692	T13690	punct	", ",8
R4141	T13693	T13690	conj	8,8
R4142	T13694	T13693	cc	and,8
R4143	T13695	T13693	conj	8,8
R4144	T13696	T13690	punct	", ",8
R4145	T13697	T13690	advmod	respectively,8
R4146	T13698	T13677	punct	),+
R4147	T13699	T13667	prep	for,measured
R4148	T13700	T13701	nummod	90,min
R4149	T13701	T13699	pobj	min,for
R415	T2416	T2417	punct	[,12
R4150	T13702	T13667	prep	in,measured
R4151	T13703	T13704	det	a,box
R4152	T13704	T13702	pobj	box,in
R4153	T13705	T13704	compound	Plexiglas,box
R4154	T13706	T13707	punct	(,cm
R4155	T13707	T13704	parataxis	cm,box
R4156	T13708	T13707	nummod	30,cm
R4157	T13709	T13710	punct	×,20
R4158	T13710	T13708	prep	20,30
R4159	T13711	T13712	punct	×,13
R416	T2417	T2401	parataxis	12,controlled
R4160	T13712	T13708	prep	13,30
R4161	T13713	T13707	punct	),cm
R4162	T13714	T13667	advcl	using,measured
R4163	T13715	T13716	det	a,equipment
R4164	T13716	T13714	dobj	equipment,using
R4165	T13717	T13716	compound	VERSAMAX,equipment
R4166	T13718	T13716	cc	and,equipment
R4167	T13719	T13716	conj	software,equipment
R4168	T13720	T13721	punct	(,Accuscan
R4169	T13721	T13716	parataxis	Accuscan,equipment
R417	T2418	T2417	punct	],12
R4170	T13722	T13721	punct	", ",Accuscan
R4171	T13723	T13721	npadvmod	Columbus,Accuscan
R4172	T13724	T13721	punct	", ",Accuscan
R4173	T13725	T13721	npadvmod	OH,Accuscan
R4174	T13726	T13721	punct	", ",Accuscan
R4175	T13727	T13721	npadvmod	USA,Accuscan
R4176	T13728	T13721	punct	),Accuscan
R4177	T13729	T13667	punct	.,measured
R4178	T14364	T14365	compound	Water,maze
R4179	T14365	T14366	compound	maze,task
R418	T2419	T2394	punct	.,reported
R4180	T14368	T14369	amod	Spatial,learning
R4181	T14369	T14370	nsubjpass	learning,assessed
R4182	T14371	T14370	auxpass	was,assessed
R4183	T14372	T14370	prep	by,assessed
R4184	T14373	T14374	nummod	three,variants
R4185	T14374	T14372	pobj	variants,by
R4186	T14375	T14374	prep	of,variants
R4187	T14376	T14377	det	the,task
R4188	T14377	T14375	pobj	task,of
R4189	T14378	T14377	compound	Morris,task
R419	T2421	T2422	prep	In,shown
R4190	T14379	T14380	compound	water,maze
R4191	T14380	T14377	compound	maze,task
R4192	T14381	T14382	punct	[,27
R4193	T14382	T14377	parataxis	27,task
R4194	T14383	T14382	punct	],27
R4195	T14384	T14374	acl	adapted,variants
R4196	T14385	T14384	prep	for,adapted
R4197	T14386	T14385	pobj	mice,for
R4198	T14387	T14370	punct	.,assessed
R4199	T14389	T14390	amod	Hidden,task
R42	T614	T611	dobj	domain,has
R420	T2423	T2424	compound	C.,elegans
R4200	T14390	T14392	dep	task,divided
R4201	T14391	T14390	compound	platform,task
R4202	T14393	T14392	punct	: ,divided
R4203	T14394	T14395	det	The,pool
R4204	T14395	T14392	nsubjpass	pool,divided
R4205	T14396	T14392	auxpass	was,divided
R4206	T14397	T14392	prep	into,divided
R4207	T14398	T14399	nummod	four,quadrants
R4208	T14399	T14397	pobj	quadrants,into
R4209	T14400	T14401	mark	with,at
R421	T2424	T2421	pobj	elegans,In
R4210	T14401	T14392	advcl	at,divided
R4211	T14402	T14403	nummod	four,locations
R4212	T14403	T14401	nsubj	locations,at
R4213	T14404	T14403	compound	starting,locations
R4214	T14405	T14403	punct	", ",locations
R4215	T14406	T14403	acl	called,locations
R4216	T14407	T14406	oprd	north,called
R4217	T14408	T14407	punct	", ",north
R4218	T14409	T14407	conj	east,north
R4219	T14410	T14409	punct	", ",east
R422	T2425	T2422	punct	", ",shown
R4220	T14411	T14409	conj	south,east
R4221	T14412	T14411	cc	and,south
R4222	T14413	T14411	conj	west,south
R4223	T14414	T14401	punct	", ",at
R4224	T14415	T14416	amod	equal,distances
R4225	T14416	T14401	pobj	distances,at
R4226	T14417	T14416	prep	to,distances
R4227	T14418	T14419	det	the,rim
R4228	T14419	T14417	pobj	rim,to
R4229	T14420	T14392	punct	.,divided
R423	T2426	T2427	nmod	unc,gene
R4230	T14422	T14423	det	A,platform
R4231	T14423	T14428	nsubjpass	platform,submerged
R4232	T14424	T14423	amod	circular,platform
R4233	T14425	T14423	punct	", ",platform
R4234	T14426	T14423	amod	transparent,platform
R4235	T14427	T14423	amod	acrylic,platform
R4236	T14429	T14430	punct	(,cm
R4237	T14430	T14423	parataxis	cm,platform
R4238	T14431	T14430	nmod	diameter,cm
R4239	T14432	T14430	nummod	8,cm
R424	T2427	T2422	nsubjpass	gene,shown
R4240	T14433	T14430	punct	),cm
R4241	T14434	T14428	auxpass	was,submerged
R4242	T14435	T14436	nummod	1,cm
R4243	T14436	T14437	npadvmod	cm,below
R4244	T14437	T14428	prep	below,submerged
R4245	T14438	T14439	det	the,surface
R4246	T14439	T14437	pobj	surface,below
R4247	T14440	T14439	prep	of,surface
R4248	T14441	T14442	det	the,water
R4249	T14442	T14440	pobj	water,of
R425	T2428	T2426	punct	-,unc
R4250	T14443	T14428	prep	in,submerged
R4251	T14444	T14445	det	the,centre
R4252	T14445	T14443	pobj	centre,in
R4253	T14446	T14445	prep	of,centre
R4254	T14447	T14448	det	the,quadrant
R4255	T14448	T14446	pobj	quadrant,of
R4256	T14449	T14448	compound	southeast,quadrant
R4257	T14450	T14428	prep	for,submerged
R4258	T14451	T14452	det	each,trial
R4259	T14452	T14450	pobj	trial,for
R426	T2429	T2426	nummod	71,unc
R4260	T14453	T14452	prep	of,trial
R4261	T14454	T14455	det	this,task
R4262	T14455	T14453	pobj	task,of
R4263	T14456	T14428	punct	.,submerged
R4264	T14458	T14459	det	Each,mouse
R4265	T14459	T14460	nsubjpass	mouse,allowed
R4266	T14461	T14460	auxpass	was,allowed
R4267	T14462	T14463	aux	to,swim
R4268	T14463	T14460	xcomp	swim,allowed
R4269	T14464	T14463	prep	for,swim
R427	T2430	T2427	acl	coding,gene
R4270	T14465	T14466	nummod	60,sec
R4271	T14466	T14464	pobj	sec,for
R4272	T14467	T14460	cc	and,allowed
R4273	T14468	T14469	det	the,time
R4274	T14469	T14470	nsubjpass	time,recorded
R4275	T14470	T14460	conj	recorded,allowed
R4276	T14471	T14469	acl	required,time
R4277	T14472	T14473	aux	to,reach
R4278	T14473	T14471	xcomp	reach,required
R4279	T14474	T14475	det	the,platform
R428	T2431	T2432	det	a,protein
R4280	T14475	T14473	dobj	platform,reach
R4281	T14476	T14469	punct	(,time
R4282	T14477	T14478	compound	escape,latency
R4283	T14478	T14469	appos	latency,time
R4284	T14479	T14469	punct	),time
R4285	T14480	T14470	auxpass	was,recorded
R4286	T14481	T14470	prep	in,recorded
R4287	T14482	T14483	det	each,trial
R4288	T14483	T14481	pobj	trial,in
R4289	T14484	T14470	punct	.,recorded
R429	T2432	T2430	dobj	protein,coding
R4290	T14486	T14487	prep	In,consisted
R4291	T14488	T14486	amod	total,In
R4292	T14489	T14490	det	this,task
R4293	T14490	T14487	nsubj	task,consisted
R4294	T14491	T14487	prep	of,consisted
R4295	T14492	T14493	nummod	four,trials
R4296	T14493	T14491	pobj	trials,of
R4297	T14494	T14493	prep	per,trials
R4298	T14495	T14494	pobj	day,per
R4299	T14496	T14487	prep	over,consisted
R43	T615	T616	npadvmod	disintegrin,like
R430	T2433	T2432	amod	non-protease,protein
R4300	T14497	T14498	nummod	9,days
R4301	T14498	T14496	pobj	days,over
R4302	T14499	T14500	punct	(,intervals
R4303	T14500	T14498	parataxis	intervals,days
R4304	T14501	T14502	nummod	1,min
R4305	T14502	T14500	nmod	min,intervals
R4306	T14503	T14500	amod	inter-trial,intervals
R4307	T14504	T14500	punct	),intervals
R4308	T14505	T14487	punct	.,consisted
R4309	T14507	T14508	det	Each,trial
R431	T2434	T2432	punct	-,protein
R4310	T14508	T14509	nsubjpass	trial,initiated
R4311	T14510	T14509	auxpass	was,initiated
R4312	T14511	T14509	agent	by,initiated
R4313	T14512	T14513	advmod	randomly,placing
R4314	T14513	T14511	pcomp	placing,by
R4315	T14514	T14515	det	an,animal
R4316	T14515	T14513	dobj	animal,placing
R4317	T14516	T14513	prep	in,placing
R4318	T14517	T14516	pobj	one,in
R4319	T14518	T14517	prep	of,one
R432	T2435	T2432	compound	ADAM,protein
R4320	T14519	T14520	det	the,locations
R4321	T14520	T14518	pobj	locations,of
R4322	T14521	T14520	nummod	four,locations
R4323	T14522	T14520	compound	starting,locations
R4324	T14523	T14509	punct	.,initiated
R4325	T14525	T14526	compound	Probe,trial
R4326	T14526	T14527	dep	trial,carried
R4327	T14528	T14527	punct	: ,carried
R4328	T14529	T14530	det	A,trial
R4329	T14530	T14527	nsubjpass	trial,carried
R433	T2436	T2422	aux	have,shown
R4330	T14531	T14530	amod	single,trial
R4331	T14532	T14530	compound	probe,trial
R4332	T14533	T14527	auxpass	was,carried
R4333	T14534	T14527	prt	out,carried
R4334	T14535	T14536	mark	after,completed
R4335	T14536	T14527	advcl	completed,carried
R4336	T14537	T14538	det	the,task
R4337	T14538	T14536	nsubjpass	task,completed
R4338	T14539	T14540	amod	hidden,platform
R4339	T14540	T14538	compound	platform,task
R434	T2437	T2422	auxpass	been,shown
R4340	T14541	T14536	aux	had,completed
R4341	T14542	T14536	auxpass	been,completed
R4342	T14543	T14527	punct	.,carried
R4343	T14545	T14546	prep	In,removed
R4344	T14547	T14548	det	this,trial
R4345	T14548	T14545	pobj	trial,In
R4346	T14549	T14546	punct	", ",removed
R4347	T14550	T14551	det	the,platform
R4348	T14551	T14546	nsubjpass	platform,removed
R4349	T14552	T14546	auxpass	was,removed
R435	T2438	T2439	aux	to,involved
R4350	T14553	T14546	cc	and,removed
R4351	T14554	T14555	det	the,movement
R4352	T14555	T14556	nsubjpass	movement,monitored
R4353	T14556	T14546	conj	monitored,removed
R4354	T14557	T14555	prep	of,movement
R4355	T14558	T14559	det	each,mouse
R4356	T14559	T14557	pobj	mouse,of
R4357	T14560	T14556	auxpass	was,monitored
R4358	T14561	T14556	advcl	using,monitored
R4359	T14562	T14563	det	a,system
R436	T2439	T2422	xcomp	involved,shown
R4360	T14563	T14561	dobj	system,using
R4361	T14564	T14565	npadvmod	computer,based
R4362	T14565	T14563	amod	based,system
R4363	T14566	T14565	punct	-,based
R4364	T14567	T14568	compound	video,tracking
R4365	T14568	T14563	compound	tracking,system
R4366	T14569	T14570	punct	(,Co.
R4367	T14570	T14561	parataxis	Co.,using
R4368	T14571	T14570	dep	BTA,Co.
R4369	T14572	T14571	punct	-,BTA
R437	T2440	T2439	auxpass	be,involved
R4370	T14573	T14571	nummod	2,BTA
R4371	T14574	T14570	punct	;,Co.
R4372	T14575	T14570	compound	Muromachi,Co.
R4373	T14576	T14570	compound	Kikai,Co.
R4374	T14577	T14570	punct	", ",Co.
R4375	T14578	T14570	amod	Ltd.,Co.
R4376	T14579	T14570	punct	", ",Co.
R4377	T14580	T14570	npadvmod	Tokyo,Co.
R4378	T14581	T14570	punct	", ",Co.
R4379	T14582	T14570	npadvmod	Japan,Co.
R438	T2441	T2439	prep	in,involved
R4380	T14583	T14570	punct	),Co.
R4381	T14584	T14546	punct	.,removed
R4382	T14586	T14587	det	Each,mouse
R4383	T14587	T14588	nsubjpass	mouse,placed
R4384	T14589	T14588	auxpass	was,placed
R4385	T14590	T14588	prep	into,placed
R4386	T14591	T14592	det	the,quadrant
R4387	T14592	T14590	pobj	quadrant,into
R4388	T14593	T14592	compound	northwest,quadrant
R4389	T14594	T14592	prep	of,quadrant
R439	T2442	T2443	compound	cell,migration
R4390	T14595	T14596	det	the,pool
R4391	T14596	T14594	pobj	pool,of
R4392	T14597	T14588	cc	and,placed
R4393	T14598	T14588	conj	allowed,placed
R4394	T14599	T14600	aux	to,swim
R4395	T14600	T14598	xcomp	swim,allowed
R4396	T14601	T14600	prep	for,swim
R4397	T14602	T14603	nummod	60,sec
R4398	T14603	T14601	pobj	sec,for
R4399	T14604	T14588	punct	.,placed
R44	T616	T614	amod	like,domain
R440	T2443	T2444	compound	migration,events
R4400	T14606	T14607	compound	Swim,path
R4401	T14607	T14608	compound	path,length
R4402	T14608	T14609	nsubjpass	length,calculated
R4403	T14610	T14608	cc	and,length
R4404	T14611	T14612	det	the,time
R4405	T14612	T14608	conj	time,length
R4406	T14613	T14612	acl	spent,time
R4407	T14614	T14613	prep	in,spent
R4408	T14615	T14616	det	the,quadrant
R4409	T14616	T14614	pobj	quadrant,in
R441	T2444	T2441	pobj	events,in
R4410	T14617	T14616	amod	trained,quadrant
R4411	T14618	T14616	punct	(,quadrant
R4412	T14619	T14616	nmod	southeast,quadrant
R4413	T14620	T14616	punct	),quadrant
R4414	T14621	T14609	auxpass	were,calculated
R4415	T14622	T14609	punct	.,calculated
R4416	T14624	T14625	amod	Visible,task
R4417	T14625	T14627	dep	task,made
R4418	T14626	T14625	compound	platform,task
R4419	T14628	T14627	punct	: ,made
R442	T2445	T2446	advmod	in,vivo
R4420	T14629	T14627	prep	In,made
R4421	T14630	T14631	det	this,task
R4422	T14631	T14629	pobj	task,In
R4423	T14632	T14627	punct	", ",made
R4424	T14633	T14634	det	the,platform
R4425	T14634	T14627	nsubjpass	platform,made
R4426	T14635	T14634	amod	circular,platform
R4427	T14636	T14627	auxpass	was,made
R4428	T14637	T14627	oprd	visible,made
R4429	T14638	T14627	prep	by,made
R443	T2446	T2439	advmod	vivo,involved
R4430	T14639	T14638	pcomp	attaching,by
R4431	T14640	T14641	det	a,board
R4432	T14641	T14639	dobj	board,attaching
R4433	T14642	T14641	amod	black,board
R4434	T14643	T14639	prep	to,attaching
R4435	T14644	T14643	pobj	it,to
R4436	T14645	T14627	cc	and,made
R4437	T14646	T14647	det	the,mouse
R4438	T14647	T14648	nsubjpass	mouse,required
R4439	T14648	T14627	conj	required,made
R444	T2447	T2448	punct	[,13
R4440	T14649	T14648	auxpass	was,required
R4441	T14650	T14651	aux	to,locate
R4442	T14651	T14648	advcl	locate,required
R4443	T14652	T14653	det	the,platform
R4444	T14653	T14651	dobj	platform,locate
R4445	T14654	T14653	amod	visible,platform
R4446	T14655	T14627	punct	.,made
R4447	T14657	T14658	det	The,mouse
R4448	T14658	T14659	nsubjpass	mouse,allowed
R4449	T14660	T14659	auxpass	was,allowed
R445	T2448	T2422	parataxis	13,shown
R4450	T14661	T14662	aux	to,swim
R4451	T14662	T14659	xcomp	swim,allowed
R4452	T14663	T14662	prep	for,swim
R4453	T14664	T14665	nummod	60,sec
R4454	T14665	T14663	pobj	sec,for
R4455	T14666	T14659	cc	and,allowed
R4456	T14667	T14668	det	this,task
R4457	T14668	T14669	nsubj	task,consisted
R4458	T14669	T14659	conj	consisted,allowed
R4459	T14670	T14669	prep	of,consisted
R446	T2449	T2448	punct	],13
R4460	T14671	T14672	nummod	four,trials
R4461	T14672	T14670	pobj	trials,of
R4462	T14673	T14672	prep	per,trials
R4463	T14674	T14673	pobj	day,per
R4464	T14675	T14672	prep	for,trials
R4465	T14676	T14677	nummod	three,days
R4466	T14677	T14675	pobj	days,for
R4467	T14678	T14677	amod	consecutive,days
R4468	T14679	T14680	punct	(,intervals
R4469	T14680	T14672	parataxis	intervals,trials
R447	T2450	T2422	punct	.,shown
R4470	T14681	T14682	nummod	1,min
R4471	T14682	T14680	nmod	min,intervals
R4472	T14683	T14680	amod	inter-trial,intervals
R4473	T14684	T14680	punct	),intervals
R4474	T14685	T14669	punct	.,consisted
R4475	T14687	T14688	det	Each,trial
R4476	T14688	T14689	nsubjpass	trial,initiated
R4477	T14690	T14689	auxpass	was,initiated
R4478	T14691	T14689	agent	by,initiated
R4479	T14692	T14693	advmod	randomly,placing
R448	T2452	T2453	advmod	However,are
R4480	T14693	T14691	pcomp	placing,by
R4481	T14694	T14695	det	an,animal
R4482	T14695	T14693	dobj	animal,placing
R4483	T14696	T14693	prep	in,placing
R4484	T14697	T14696	pobj	one,in
R4485	T14698	T14697	prep	of,one
R4486	T14699	T14700	det	the,locations
R4487	T14700	T14698	pobj	locations,of
R4488	T14701	T14700	nummod	four,locations
R4489	T14702	T14700	compound	starting,locations
R449	T2454	T2453	punct	", ",are
R4490	T14703	T14689	punct	.,initiated
R4491	T14924	T14925	amod	Rotating,rod
R4492	T14925	T14926	compound	rod,test
R4493	T14928	T14929	compound	Motor,coordination
R4494	T14929	T14930	nsubjpass	coordination,assessed
R4495	T14931	T14930	auxpass	was,assessed
R4496	T14932	T14930	prep	with,assessed
R4497	T14933	T14934	det	a,apparatus
R4498	T14934	T14932	pobj	apparatus,with
R4499	T14935	T14936	amod	rotating,rod
R45	T617	T616	punct	-,like
R450	T2455	T2456	det	the,roles
R4500	T14936	T14934	compound	rod,apparatus
R4501	T14937	T14938	punct	(,Seisakujo
R4502	T14938	T14934	parataxis	Seisakujo,apparatus
R4503	T14939	T14938	dep	KN,Seisakujo
R4504	T14940	T14939	punct	-,KN
R4505	T14941	T14939	nummod	75,KN
R4506	T14942	T14938	punct	", ",Seisakujo
R4507	T14943	T14938	compound	Natsume,Seisakujo
R4508	T14944	T14938	punct	", ",Seisakujo
R4509	T14945	T14938	npadvmod	Tokyo,Seisakujo
R451	T2456	T2453	nsubj	roles,are
R4510	T14946	T14938	punct	", ",Seisakujo
R4511	T14947	T14938	npadvmod	Japan,Seisakujo
R4512	T14948	T14938	punct	),Seisakujo
R4513	T14949	T14934	punct	", ",apparatus
R4514	T14950	T14951	dep	which,consisted
R4515	T14951	T14934	relcl	consisted,apparatus
R4516	T14952	T14951	prep	of,consisted
R4517	T14953	T14954	det	a,rod
R4518	T14954	T14952	pobj	rod,of
R4519	T14955	T14954	compound	plastic,rod
R452	T2457	T2456	amod	physiological,roles
R4520	T14956	T14957	punct	(,diameter
R4521	T14957	T14954	parataxis	diameter,rod
R4522	T14958	T14959	nummod	3,cm
R4523	T14959	T14957	compound	cm,diameter
R4524	T14960	T14957	punct	", ",diameter
R4525	T14961	T14962	nummod	8,cm
R4526	T14962	T14963	npadvmod	cm,long
R4527	T14963	T14957	amod	long,diameter
R4528	T14964	T14957	punct	),diameter
R4529	T14965	T14954	prep	with,rod
R453	T2458	T2456	prep	of,roles
R4530	T14966	T14967	det	a,surface
R4531	T14967	T14965	pobj	surface,with
R4532	T14968	T14967	amod	gritted,surface
R4533	T14969	T14967	acl	flanked,surface
R4534	T14970	T14969	agent	by,flanked
R4535	T14971	T14972	nummod	two,discs
R4536	T14972	T14970	pobj	discs,by
R4537	T14973	T14972	amod	large,discs
R4538	T14974	T14975	punct	(,diameter
R4539	T14975	T14972	parataxis	diameter,discs
R454	T2459	T2460	amod	mammalian,ADAMs
R4540	T14976	T14977	nummod	40,cm
R4541	T14977	T14975	compound	cm,diameter
R4542	T14978	T14975	punct	),diameter
R4543	T14979	T14930	punct	.,assessed
R4544	T14981	T14982	det	The,mice
R4545	T14982	T14983	nsubjpass	mice,placed
R4546	T14984	T14983	auxpass	were,placed
R4547	T14985	T14983	advmod	first,placed
R4548	T14986	T14983	prep	on,placed
R4549	T14987	T14988	det	the,rod
R455	T2460	T2458	pobj	ADAMs,of
R4550	T14988	T14986	pobj	rod,on
R4551	T14989	T14988	amod	stationary,rod
R4552	T14990	T14983	prep	for,placed
R4553	T14991	T14992	nummod	4,trials
R4554	T14992	T14990	pobj	trials,for
R4555	T14993	T14992	amod	successive,trials
R4556	T14994	T14992	punct	", ",trials
R4557	T14995	T14992	acl	followed,trials
R4558	T14996	T14995	agent	by,followed
R4559	T14997	T14998	nummod	4,trials
R456	T2461	T2460	amod	non-protease,ADAMs
R4560	T14998	T14996	pobj	trials,by
R4561	T14999	T14998	prep	at,trials
R4562	T15000	T15001	det	a,speed
R4563	T15001	T14999	pobj	speed,at
R4564	T15002	T15001	compound	rotation,speed
R4565	T15003	T15001	prep	of,speed
R4566	T15004	T15005	nummod	5,rpm
R4567	T15005	T15003	pobj	rpm,of
R4568	T15006	T14998	punct	", ",trials
R4569	T15007	T15008	nummod	8,trials
R457	T2462	T2460	punct	-,ADAMs
R4570	T15008	T14998	conj	trials,trials
R4571	T15009	T15008	prep	at,trials
R4572	T15010	T15011	nummod	10,rpm
R4573	T15011	T15009	pobj	rpm,at
R4574	T15012	T15008	punct	", ",trials
R4575	T15013	T15008	cc	and,trials
R4576	T15014	T15015	nummod	20,trials
R4577	T15015	T15008	conj	trials,trials
R4578	T15016	T15015	prep	at,trials
R4579	T15017	T15018	nummod	15,rpm
R458	T2463	T2464	advmod	poorly,understood
R4580	T15018	T15016	pobj	rpm,at
R4581	T15019	T14998	prep	in,trials
R4582	T15020	T15021	det	that,order
R4583	T15021	T15019	pobj	order,in
R4584	T15022	T14983	punct	.,placed
R4585	T15024	T15025	nsubjpass	Latency,monitored
R4586	T15026	T15027	mark	until,occurred
R4587	T15027	T15024	advcl	occurred,Latency
R4588	T15028	T15029	det	a,fall
R4589	T15029	T15027	nsubj	fall,occurred
R459	T2464	T2453	acomp	understood,are
R4590	T15030	T15025	auxpass	was,monitored
R4591	T15031	T15025	prep	for,monitored
R4592	T15032	T15033	nummod	120,sec
R4593	T15033	T15031	pobj	sec,for
R4594	T15034	T15025	punct	.,monitored
R4595	T15036	T15037	amod	Intra-trial,intervals
R4596	T15037	T15038	nsubj	intervals,were
R4597	T15039	T15037	prep	for,intervals
R4598	T15040	T15041	det	each,animal
R4599	T15041	T15039	pobj	animal,for
R46	T618	T614	prep	related,domain
R460	T2465	T2466	advmod	in,vivo
R4600	T15042	T15043	amod	more,20
R4601	T15043	T15045	nummod	20,min
R4602	T15044	T15043	quantmod	than,20
R4603	T15045	T15038	attr	min,were
R4604	T15046	T15038	punct	.,were
R4605	T15164	T15165	compound	Traction,test
R4606	T15167	T15168	det	The,strength
R4607	T15168	T15170	nsubjpass	strength,measured
R4608	T15169	T15168	compound	grip,strength
R4609	T15171	T15168	prep	of,strength
R461	T2466	T2453	advmod	vivo,are
R4610	T15172	T15173	det	each,mouse
R4611	T15173	T15171	pobj	mouse,of
R4612	T15174	T15170	auxpass	was,measured
R4613	T15175	T15170	prep	with,measured
R4614	T15176	T15177	det	a,apparatus
R4615	T15177	T15175	pobj	apparatus,with
R4616	T15178	T15177	compound	traction,apparatus
R4617	T15179	T15180	punct	(,Co.
R4618	T15180	T15177	parataxis	Co.,apparatus
R4619	T15181	T15180	dep	FU,Co.
R462	T2467	T2453	punct	.,are
R4620	T15182	T15181	punct	-,FU
R4621	T15183	T15181	nummod	1,FU
R4622	T15184	T15180	punct	", ",Co.
R4623	T15185	T15180	compound	Muromachi,Co.
R4624	T15186	T15180	compound	Kikai,Co.
R4625	T15187	T15180	punct	", ",Co.
R4626	T15188	T15180	amod	Ltd.,Co.
R4627	T15189	T15180	punct	),Co.
R4628	T15190	T15170	punct	.,measured
R4629	T15192	T15193	det	Each,mouse
R463	T2469	T2470	amod	Genetic,deletion
R4630	T15193	T15194	nsubjpass	mouse,made
R4631	T15195	T15194	auxpass	was,made
R4632	T15196	T15197	aux	to,grasp
R4633	T15197	T15194	xcomp	grasp,made
R4634	T15198	T15199	det	the,bar
R4635	T15199	T15197	dobj	bar,grasp
R4636	T15200	T15199	amod	attached,bar
R4637	T15201	T15202	punct	(,diameter
R4638	T15202	T15199	parataxis	diameter,bar
R4639	T15203	T15204	nummod	2,mm
R464	T2470	T2471	compound	deletion,studies
R4640	T15204	T15202	compound	mm,diameter
R4641	T15205	T15202	punct	),diameter
R4642	T15206	T15197	prep	with,grasp
R4643	T15207	T15208	det	the,forepaws
R4644	T15208	T15206	pobj	forepaws,with
R4645	T15209	T15194	cc	and,made
R4646	T15210	T15211	auxpass	was,pulled
R4647	T15211	T15194	conj	pulled,made
R4648	T15212	T15211	advmod	slowly,pulled
R4649	T15213	T15211	advmod	back,pulled
R465	T2471	T2472	nsubj	studies,shown
R4650	T15214	T15211	prep	by,pulled
R4651	T15215	T15216	det	the,tail
R4652	T15216	T15214	pobj	tail,by
R4653	T15217	T15194	punct	.,made
R4654	T15219	T15220	det	The,tension
R4655	T15220	T15222	nsubjpass	tension,recorded
R4656	T15221	T15220	amod	maximum,tension
R4657	T15223	T15220	prep	before,tension
R4658	T15224	T15223	pobj	release,before
R4659	T15225	T15222	auxpass	was,recorded
R466	T2473	T2471	prep	in,studies
R4660	T15226	T15222	punct	.,recorded
R4661	T15486	T15487	compound	Wire,suspension
R4662	T15487	T15488	compound	suspension,test
R4663	T15490	T15491	det	A,mouse
R4664	T15491	T15492	nsubjpass	mouse,placed
R4665	T15493	T15492	auxpass	was,placed
R4666	T15494	T15492	prep	on,placed
R4667	T15495	T15496	det	a,bar
R4668	T15496	T15494	pobj	bar,on
R4669	T15497	T15496	amod	stainless,bar
R467	T2474	T2473	pobj	mice,in
R4670	T15498	T15499	punct	(,diameter
R4671	T15499	T15496	parataxis	diameter,bar
R4672	T15500	T15501	nummod	50,cm
R4673	T15501	T15502	compound	cm,length
R4674	T15502	T15499	dep	length,diameter
R4675	T15503	T15499	punct	", ",diameter
R4676	T15504	T15505	nummod	2,mm
R4677	T15505	T15499	compound	mm,diameter
R4678	T15506	T15499	punct	", ",diameter
R4679	T15507	T15499	advcl	elevated,diameter
R468	T2475	T2472	aux	have,shown
R4680	T15508	T15509	advmod	up,37
R4681	T15509	T15511	nummod	37,cm
R4682	T15510	T15509	quantmod	to,37
R4683	T15511	T15507	npadvmod	cm,elevated
R4684	T15512	T15511	prep	from,cm
R4685	T15513	T15514	det	a,surface
R4686	T15514	T15512	pobj	surface,from
R4687	T15515	T15499	punct	),diameter
R4688	T15516	T15492	prep	at,placed
R4689	T15517	T15518	det	a,midway
R469	T2476	T2477	mark	that,are
R4690	T15518	T15516	pobj	midway,at
R4691	T15519	T15518	compound	point,midway
R4692	T15520	T15518	prep	between,midway
R4693	T15521	T15522	det	the,supports
R4694	T15522	T15520	pobj	supports,between
R4695	T15523	T15492	cc	and,placed
R4696	T15524	T15492	conj	observed,placed
R4697	T15525	T15524	prep	for,observed
R4698	T15526	T15527	nummod	30,sec
R4699	T15527	T15525	pobj	sec,for
R47	T619	T618	prep	to,related
R470	T2477	T2472	ccomp	are,shown
R4700	T15528	T15524	prep	in,observed
R4701	T15529	T15530	nummod	four,trials
R4702	T15530	T15528	pobj	trials,in
R4703	T15531	T15530	amod	separate,trials
R4704	T15532	T15492	punct	.,placed
R4705	T15534	T15535	det	The,amount
R4706	T15535	T15536	nsubjpass	amount,recorded
R4707	T15537	T15535	prep	of,amount
R4708	T15538	T15537	pobj	time,of
R4709	T15539	T15538	acl	spent,time
R471	T2478	T2479	preconj	both,mutants
R4710	T15540	T15539	advcl	hanging,spent
R4711	T15541	T15536	auxpass	was,recorded
R4712	T15542	T15536	cc	and,recorded
R4713	T15543	T15536	conj	scored,recorded
R4714	T15544	T15543	prep	according,scored
R4715	T15545	T15544	prep	to,according
R4716	T15546	T15547	det	the,system
R4717	T15547	T15545	pobj	system,to
R4718	T15548	T15547	amod	following,system
R4719	T15549	T15550	punct	[,41
R472	T2479	T2477	nsubj	mutants,are
R4720	T15550	T15543	parataxis	41,scored
R4721	T15551	T15550	punct	],41
R4722	T15552	T15536	punct	: ,recorded
R4723	T15553	T15554	dep	0,fell
R4724	T15554	T15556	dep	fell,escaped
R4725	T15555	T15554	punct	", ",fell
R4726	T15556	T15536	dep	escaped,recorded
R4727	T15557	T15554	prt	off,fell
R4728	T15558	T15556	punct	;,escaped
R4729	T15559	T15560	dep	1,hung
R473	T2480	T2481	npadvmod	Adam2,null
R4730	T15560	T15556	dep	hung,escaped
R4731	T15561	T15560	punct	", ",hung
R4732	T15562	T15560	prep	onto,hung
R4733	T15563	T15564	det	the,bar
R4734	T15564	T15562	pobj	bar,onto
R4735	T15565	T15560	prep	with,hung
R4736	T15566	T15567	nummod	two,forepaws
R4737	T15567	T15565	pobj	forepaws,with
R4738	T15568	T15556	punct	;,escaped
R4739	T15569	T15570	dep	2,attempted
R474	T2481	T2479	amod	null,mutants
R4740	T15570	T15556	dep	attempted,escaped
R4741	T15571	T15570	punct	", ",attempted
R4742	T15572	T15570	prep	in,attempted
R4743	T15573	T15572	pobj	addition,in
R4744	T15574	T15573	prep	to,addition
R4745	T15575	T15574	pobj	1,to
R4746	T15576	T15570	punct	", ",attempted
R4747	T15577	T15578	aux	to,climb
R4748	T15578	T15570	xcomp	climb,attempted
R4749	T15579	T15578	prep	onto,climb
R475	T2482	T2481	punct	-,null
R4750	T15580	T15581	det	the,bar
R4751	T15581	T15579	pobj	bar,onto
R4752	T15582	T15556	punct	;,escaped
R4753	T15583	T15584	dep	3,hung
R4754	T15584	T15556	dep	hung,escaped
R4755	T15585	T15584	punct	", ",hung
R4756	T15586	T15584	prep	onto,hung
R4757	T15587	T15588	det	the,bar
R4758	T15588	T15586	pobj	bar,onto
R4759	T15589	T15584	prep	with,hung
R476	T2483	T2481	cc	and,null
R4760	T15590	T15591	nummod	two,forepaws
R4761	T15591	T15589	pobj	forepaws,with
R4762	T15592	T15591	cc	and,forepaws
R4763	T15593	T15594	nummod	one,paws
R4764	T15594	T15591	conj	paws,forepaws
R4765	T15595	T15593	cc	or,one
R4766	T15596	T15593	preconj	both,one
R4767	T15597	T15594	compound	hind,paws
R4768	T15598	T15556	punct	;,escaped
R4769	T15599	T15600	dep	4,hung
R477	T2484	T2485	npadvmod	Adam3,null
R4770	T15600	T15556	dep	hung,escaped
R4771	T15601	T15600	punct	", ",hung
R4772	T15602	T15600	prep	onto,hung
R4773	T15603	T15604	det	the,bar
R4774	T15604	T15602	pobj	bar,onto
R4775	T15605	T15600	prep	with,hung
R4776	T15606	T15607	det	all,paws
R4777	T15607	T15605	pobj	paws,with
R4778	T15608	T15607	nummod	four,paws
R4779	T15609	T15600	prep	with,hung
R478	T2485	T2481	conj	null,null
R4780	T15610	T15609	pobj	tail,with
R4781	T15611	T15610	acl	wrapped,tail
R4782	T15612	T15611	prep	around,wrapped
R4783	T15613	T15614	det	the,bar
R4784	T15614	T15612	pobj	bar,around
R4785	T15615	T15556	punct	;,escaped
R4786	T15616	T15556	dep	5,escaped
R4787	T15617	T15556	punct	", ",escaped
R4788	T15618	T15556	prep	to,escaped
R4789	T15619	T15618	pobj	one,to
R479	T2486	T2485	punct	-,null
R4790	T15620	T15619	prep	of,one
R4791	T15621	T15622	det	the,supports
R4792	T15622	T15620	pobj	supports,of
R4793	T15623	T15536	punct	.,recorded
R4794	T15705	T15706	compound	Footprint,test
R4795	T15708	T15709	amod	Black,ink
R4796	T15709	T15710	nsubjpass	ink,applied
R4797	T15711	T15710	auxpass	was,applied
R4798	T15712	T15710	prep	to,applied
R4799	T15713	T15714	det	the,paws
R48	T620	T621	nmod	cell,cell
R480	T2487	T2479	amod	male,mutants
R4800	T15714	T15712	pobj	paws,to
R4801	T15715	T15714	compound	hind,paws
R4802	T15716	T15714	prep	of,paws
R4803	T15717	T15718	det	each,mouse
R4804	T15718	T15716	pobj	mouse,of
R4805	T15719	T15710	cc	and,applied
R4806	T15720	T15721	det	the,mice
R4807	T15721	T15722	nsubjpass	mice,placed
R4808	T15722	T15710	conj	placed,applied
R4809	T15723	T15722	auxpass	were,placed
R481	T2488	T2477	acomp	infertile,are
R4810	T15724	T15722	prep	in,placed
R4811	T15725	T15726	det	a,alley
R4812	T15726	T15724	pobj	alley,in
R4813	T15727	T15726	amod	narrow,alley
R4814	T15728	T15729	punct	(,cm
R4815	T15729	T15726	parataxis	cm,alley
R4816	T15730	T15731	nummod	9,10
R4817	T15731	T15729	nummod	10,cm
R4818	T15732	T15731	punct	×,10
R4819	T15733	T15731	nummod	25,10
R482	T2489	T2477	cc	and,are
R4820	T15734	T15731	punct	×,10
R4821	T15735	T15729	punct	),cm
R4822	T15736	T15722	prep	on,placed
R4823	T15737	T15738	amod	white,paper
R4824	T15738	T15736	pobj	paper,on
R4825	T15739	T15722	punct	.,placed
R4826	T15741	T15742	compound	Stride,length
R4827	T15742	T15743	nsubjpass	length,calculated
R4828	T15744	T15742	cc	and,length
R4829	T15745	T15746	compound	step,width
R483	T2490	T2491	poss	their,spermatozoa
R4830	T15746	T15742	conj	width,length
R4831	T15747	T15743	auxpass	were,calculated
R4832	T15748	T15743	punct	.,calculated
R4833	T15951	T15952	nsubjpass	Data,expressed
R4834	T15953	T15952	auxpass	are,expressed
R4835	T15954	T15952	prep	as,expressed
R4836	T15955	T15956	det	the,SEM
R4837	T15956	T15954	pobj	SEM,as
R4838	T15957	T15956	nmod	means,SEM
R4839	T15958	T15956	punct	±,SEM
R484	T2491	T2492	nsubj	spermatozoa,lack
R4840	T15959	T15952	punct	.,expressed
R4841	T15961	T15962	amod	Statistical,analysis
R4842	T15962	T15963	nsubjpass	analysis,conducted
R4843	T15964	T15963	auxpass	was,conducted
R4844	T15965	T15963	advcl	using,conducted
R4845	T15966	T15967	det	the,package
R4846	T15967	T15965	dobj	package,using
R4847	T15968	T15967	compound	software,package
R4848	T15969	T15967	appos	SAS,package
R4849	T15970	T15969	nummod	8.1,SAS
R485	T2492	T2477	conj	lack,are
R4850	T15971	T15972	punct	(,Japan
R4851	T15972	T15967	parataxis	Japan,package
R4852	T15973	T15972	compound	SAS,Japan
R4853	T15974	T15972	compound	Institute,Japan
R4854	T15975	T15972	amod	Ltd.,Japan
R4855	T15976	T15972	punct	", ",Japan
R4856	T15977	T15972	npadvmod	Tokyo,Japan
R4857	T15978	T15972	punct	", ",Japan
R4858	T15979	T15972	npadvmod	Japan,Japan
R4859	T15980	T15972	punct	),Japan
R486	T2493	T2494	nmod	egg,abilities
R4860	T15981	T15963	punct	.,conducted
R4861	T15983	T15984	amod	Statistical,significance
R4862	T15984	T15985	nsubjpass	significance,determined
R4863	T15986	T15985	auxpass	was,determined
R4864	T15987	T15985	prep	by,determined
R4865	T15988	T15987	pobj	analysis,by
R4866	T15989	T15988	prep	of,analysis
R4867	T15990	T15989	pobj	variance,of
R4868	T15991	T15988	punct	(,analysis
R4869	T15992	T15988	appos	ANOVA,analysis
R487	T2494	T2492	dobj	abilities,lack
R4870	T15993	T15988	punct	),analysis
R4871	T15994	T15988	acl	followed,analysis
R4872	T15995	T15994	agent	by,followed
R4873	T15996	T15997	det	the,test
R4874	T15997	T15995	pobj	test,by
R4875	T15998	T15999	nmod	Dunnett,type
R4876	T15999	T15997	nmod	type,test
R4877	T16000	T15999	punct	-,type
R4878	T16001	T16002	amod	multiple,comparison
R4879	T16002	T15997	compound	comparison,test
R488	T2495	T2493	punct	-,egg
R4880	T16003	T15985	punct	", ",determined
R4881	T16004	T15985	cc	and,determined
R4882	T16005	T16006	compound	p,values
R4883	T16006	T16007	nsubjpass	values,considered
R4884	T16007	T15985	conj	considered,determined
R4885	T16008	T16006	prep	of,values
R4886	T16009	T16010	amod	less,0.05
R4887	T16010	T16008	pobj	0.05,of
R4888	T16011	T16010	quantmod	than,0.05
R4889	T16012	T16007	auxpass	were,considered
R489	T2496	T2493	amod	binding,egg
R4890	T16013	T16014	aux	to,be
R4891	T16014	T16007	xcomp	be,considered
R4892	T16015	T16014	acomp	significant,be
R4893	T16016	T16014	prep	in,be
R4894	T16017	T16018	det	the,task
R4895	T16018	T16016	pobj	task,in
R4896	T16019	T16020	compound	water,maze
R4897	T16020	T16018	compound	maze,task
R4898	T16021	T16007	punct	.,considered
R4899	T16023	T16024	amod	Behavioural,data
R49	T621	T623	nmod	cell,interactions
R490	T2497	T2498	punct	[,14
R4900	T16024	T16025	nsubjpass	data,analysed
R4901	T16026	T16024	prep	in,data
R4902	T16027	T16028	det	the,test
R4903	T16028	T16026	pobj	test,in
R4904	T16029	T16030	amod	rotating,rod
R4905	T16030	T16028	compound	rod,test
R4906	T16031	T16025	auxpass	were,analysed
R4907	T16032	T16025	agent	by,analysed
R4908	T16033	T16034	nummod	one,way
R4909	T16034	T16039	compound	way,ANOVA
R491	T2498	T2492	parataxis	14,lack
R4910	T16035	T16033	punct	-,one
R4911	T16036	T16033	cc	or,one
R4912	T16037	T16033	conj	two,one
R4913	T16038	T16034	punct	-,way
R4914	T16039	T16032	pobj	ANOVA,by
R4915	T16040	T16039	prep	with,ANOVA
R4916	T16041	T16042	amod	repeated,measures
R4917	T16042	T16040	pobj	measures,with
R4918	T16043	T16025	punct	", ",analysed
R4919	T16044	T16025	cc	and,analysed
R492	T2499	T2500	punct	-,16
R4920	T16045	T16046	compound	p,values
R4921	T16046	T16047	nsubjpass	values,considered
R4922	T16047	T16025	conj	considered,analysed
R4923	T16048	T16046	prep	of,values
R4924	T16049	T16050	amod	less,0.05
R4925	T16050	T16048	pobj	0.05,of
R4926	T16051	T16050	quantmod	than,0.05
R4927	T16052	T16047	auxpass	were,considered
R4928	T16053	T16054	aux	to,be
R4929	T16054	T16047	xcomp	be,considered
R493	T2500	T2498	prep	16,14
R4930	T16055	T16054	acomp	significant,be
R4931	T16056	T16047	punct	.,considered
R4932	T16223	T16224	nsubjpass	Sections,fixed
R4933	T16225	T16223	prep	of,Sections
R4934	T16226	T16225	pobj	tissues,of
R4935	T16227	T16226	prep	including,tissues
R4936	T16228	T16229	det	the,brain
R4937	T16229	T16227	pobj	brain,including
R4938	T16230	T16229	punct	", ",brain
R4939	T16231	T16232	amod	spinal,cord
R494	T2501	T2498	punct	],14
R4940	T16232	T16229	conj	cord,brain
R4941	T16233	T16232	punct	", ",cord
R4942	T16234	T16232	conj	heart,cord
R4943	T16235	T16234	punct	", ",heart
R4944	T16236	T16234	conj	lung,heart
R4945	T16237	T16236	punct	", ",lung
R4946	T16238	T16236	conj	liver,lung
R4947	T16239	T16238	punct	", ",liver
R4948	T16240	T16238	conj	kidney,liver
R4949	T16241	T16240	punct	", ",kidney
R495	T2502	T2472	punct	.,shown
R4950	T16242	T16240	conj	spleen,kidney
R4951	T16243	T16242	cc	and,spleen
R4952	T16244	T16242	conj	testis,spleen
R4953	T16245	T16223	prep	from,Sections
R4954	T16246	T16245	pobj	mice,from
R4955	T16247	T16248	punct	(,+
R4956	T16248	T16246	punct	+,mice
R4957	T16249	T16248	punct	+,+
R4958	T16250	T16248	punct	/,+
R4959	T16251	T16248	punct	", ",+
R496	T2504	T2505	det	The,mechanism
R4960	T16252	T16253	punct	+,-
R4961	T16253	T16248	conj	-,+
R4962	T16254	T16253	punct	/,-
R4963	T16255	T16253	cc	and,-
R4964	T16256	T16257	punct	-,-
R4965	T16257	T16253	conj	-,-
R4966	T16258	T16257	punct	/,-
R4967	T16259	T16248	punct	;,+
R4968	T16260	T16261	nsubj	n,7
R4969	T16261	T16248	ccomp	7,+
R497	T2505	T2507	nsubj	mechanism,is
R4970	T16262	T16261	punct	=,7
R4971	T16263	T16261	punct	", ",7
R4972	T16264	T16261	conj	7,7
R4973	T16265	T16264	cc	and,7
R4974	T16266	T16264	conj	7,7
R4975	T16267	T16261	punct	", ",7
R4976	T16268	T16261	advmod	respectively,7
R4977	T16269	T16248	punct	),+
R4978	T16270	T16224	auxpass	were,fixed
R4979	T16271	T16224	prep	in,fixed
R498	T2506	T2505	amod	precise,mechanism
R4980	T16272	T16273	nummod	10,%
R4981	T16273	T16274	nmod	%,formalin
R4982	T16274	T16271	pobj	formalin,in
R4983	T16275	T16274	amod	buffered,formalin
R4984	T16276	T16224	cc	and,fixed
R4985	T16277	T16224	conj	embedded,fixed
R4986	T16278	T16277	prep	in,embedded
R4987	T16279	T16278	pobj	paraffin,in
R4988	T16280	T16224	punct	.,fixed
R4989	T16282	T16283	det	Each,section
R499	T2508	T2507	prep	under,is
R4990	T16283	T16285	nsubjpass	section,stained
R4991	T16284	T16283	compound	paraffin,section
R4992	T16286	T16283	prep	of,section
R4993	T16287	T16288	amod	thick,μm
R4994	T16288	T16286	pobj	μm,of
R4995	T16289	T16288	nummod	4,μm
R4996	T16290	T16285	auxpass	was,stained
R4997	T16291	T16285	prep	with,stained
R4998	T16292	T16291	pobj	hematoxylin,with
R4999	T16293	T16292	cc	and,hematoxylin
R5	T569	T567	pobj	learning,in
R50	T622	T621	punct	-,cell
R500	T2509	T2508	pobj	investigation,under
R5000	T16294	T16292	conj	eosin,hematoxylin
R5001	T16295	T16292	punct	(,hematoxylin
R5002	T16296	T16292	appos	HE,hematoxylin
R5003	T16297	T16285	punct	),stained
R5004	T16298	T16285	punct	.,stained
R501	T2510	T2511	punct	[,17
R502	T2511	T2507	parataxis	17,is
R503	T2512	T2511	punct	],17
R504	T2513	T2507	punct	.,is
R505	T2515	T2516	nsubj	We,reported
R506	T2517	T2516	aux	have,reported
R507	T2518	T2519	det	the,findings
R508	T2519	T2516	dobj	findings,reported
R509	T2520	T2519	prep	of,findings
R51	T623	T619	pobj	interactions,to
R510	T2521	T2522	nmod	ADAM11,genes
R511	T2522	T2520	pobj	genes,of
R512	T2523	T2521	punct	", ",ADAM11
R513	T2524	T2521	conj	ADAM22,ADAM11
R514	T2525	T2524	cc	and,ADAM22
R515	T2526	T2524	conj	ADAM23,ADAM22
R516	T2527	T2522	cc	and,genes
R517	T2528	T2529	poss	their,expression
R518	T2529	T2522	conj	expression,genes
R519	T2636	T2635	aux	has,reported
R52	T624	T621	cc	or,cell
R520	T2530	T2529	amod	restricted,expression
R521	T2637	T2635	auxpass	been,reported
R522	T2531	T2529	prep	in,expression
R523	T2638	T2639	mark	that,results
R524	T2532	T2533	det	the,systems
R525	T2639	T2635	ccomp	results,reported
R526	T2533	T2531	pobj	systems,in
R527	T2640	T2641	det	the,disruption
R528	T2534	T2533	amod	human,systems
R529	T2535	T2534	cc	and,human
R53	T625	T626	nmod	cell,matrix
R530	T2641	T2639	nsubj	disruption,results
R531	T2536	T2534	conj	murine,human
R532	T2537	T2533	amod	nervous,systems
R533	T2538	T2539	punct	[,19
R534	T2539	T2516	parataxis	19,reported
R535	T2540	T2539	nummod	18,19
R536	T2541	T2539	punct	",",19
R537	T2642	T2641	prep	of,disruption
R538	T2542	T2539	punct	],19
R539	T2543	T2516	punct	.,reported
R54	T626	T621	conj	matrix,cell
R540	T2643	T2644	compound	Adam23,gene
R541	T2545	T2546	det	These,ADAMs
R542	T2644	T2642	pobj	gene,of
R543	T2645	T2641	prep	in,disruption
R544	T2546	T2547	nsubj	ADAMs,lack
R545	T2646	T2647	det	the,mouse
R546	T2548	T2549	det	a,motif
R547	T2549	T2547	dobj	motif,lack
R548	T2647	T2645	pobj	mouse,in
R549	T2550	T2549	amod	catalytic,motif
R55	T627	T626	punct	-,matrix
R550	T2551	T2549	amod	critical,motif
R551	T2648	T2639	prep	in,results
R552	T2552	T2551	prep	for,critical
R553	T2553	T2554	det	the,activity
R554	T2554	T2552	pobj	activity,for
R555	T2649	T2650	amod	premature,death
R556	T2555	T2554	compound	metalloproteinase,activity
R557	T2556	T2547	punct	", ",lack
R558	T2557	T2547	advcl	suggesting,lack
R559	T2650	T2648	pobj	death,in
R56	T628	T602	punct	.,thought
R560	T2558	T2559	mark	that,are
R561	T2559	T2557	ccomp	are,suggesting
R562	T2560	T2559	nsubj	they,are
R563	T2651	T2650	acl	associated,death
R564	T2561	T2559	neg	not,are
R565	T2652	T2651	prep	with,associated
R566	T2562	T2559	attr	proteases,are
R567	T2563	T2547	punct	.,lack
R568	T2565	T2566	nsubj	We,assume
R569	T2653	T2652	pobj	ataxia,with
R57	T630	T631	aux	To,elucidate
R570	T2567	T2568	mark	that,contribute
R571	T2654	T2653	cc	and,ataxia
R572	T2568	T2566	ccomp	contribute,assume
R573	T2569	T2570	det	these,ADAMs
R574	T2570	T2568	nsubj	ADAMs,contribute
R575	T2655	T2653	conj	tremor,ataxia
R576	T2571	T2568	aux	might,contribute
R577	T2572	T2568	prep	to,contribute
R578	T2573	T2574	compound	cell,migration
R579	T2574	T2572	pobj	migration,to
R58	T631	T632	advcl	elucidate,generated
R580	T2656	T2657	punct	[,23
R581	T2575	T2574	punct	", ",migration
R582	T2576	T2574	conj	differentiation,migration
R583	T2657	T2635	parataxis	23,reported
R584	T2577	T2576	cc	and,differentiation
R585	T2578	T2576	conj	survival,differentiation
R586	T2579	T2574	cc	or,migration
R587	T2580	T2581	amod	synaptic,regulation
R588	T2581	T2574	conj	regulation,migration
R589	T2582	T2568	prep	by,contribute
R59	T633	T634	det	the,functions
R590	T2583	T2582	pcomp	binding,by
R591	T2658	T2657	punct	],23
R592	T2584	T2583	prep	to,binding
R593	T2585	T2584	pobj	integrins,to
R594	T2586	T2585	punct	", ",integrins
R595	T2659	T2635	punct	.,reported
R596	T2587	T2588	compound	cell,surface
R597	T2588	T2590	compound	surface,proteins
R598	T2589	T2588	punct	-,surface
R599	T2661	T2662	prep	Is,observed
R6	T570	T569	cc	and,learning
R60	T634	T631	dobj	functions,elucidate
R600	T2590	T2585	conj	proteins,integrins
R601	T2591	T2590	cc	or,proteins
R602	T2592	T2593	amod	intracellular,molecules
R603	T2593	T2590	conj	molecules,proteins
R604	T2663	T2661	pobj	spite,Is
R605	T2594	T2593	compound	signalling,molecules
R606	T2595	T2596	punct	[,21
R607	T2596	T2568	parataxis	21,contribute
R608	T2597	T2596	nummod	20,21
R609	T2598	T2596	punct	",",21
R61	T635	T634	amod	physiological,functions
R610	T2664	T2663	prep	of,spite
R611	T2599	T2596	punct	],21
R612	T2600	T2566	punct	.,assume
R613	T2665	T2666	amod	such,phenotypes
R614	T2602	T2603	nsubj	We,reported
R615	T2666	T2664	pobj	phenotypes,of
R616	T2604	T2603	aux	have,reported
R617	T2667	T2666	amod	extreme,phenotypes
R618	T2605	T2606	amod	severe,ataxia
R619	T2606	T2603	dobj	ataxia,reported
R62	T636	T634	prep	of,functions
R620	T2607	T2606	punct	", ",ataxia
R621	T2668	T2662	punct	", ",observed
R622	T2608	T2606	conj	seizures,ataxia
R623	T2609	T2608	punct	", ",seizures
R624	T2610	T2608	cc	and,seizures
R625	T2669	T2670	det	no,defects
R626	T2611	T2608	conj	death,seizures
R627	T2612	T2611	prep	before,death
R628	T2613	T2612	pobj	weaning,before
R629	T2670	T2662	nsubjpass	defects,observed
R63	T637	T636	pobj	ADAM11,of
R630	T2614	T2606	punct	", ",ataxia
R631	T2615	T2606	acl	accompanied,ataxia
R632	T2671	T2670	amod	histological,defects
R633	T2616	T2615	prep	with,accompanied
R634	T2617	T2616	pobj	hypomyelination,with
R635	T2618	T2617	prep	of,hypomyelination
R636	T2672	T2670	prep	in,defects
R637	T2619	T2620	det	the,system
R638	T2673	T2674	det	the,brain
R639	T2620	T2618	pobj	system,of
R64	T638	T632	punct	", ",generated
R640	T2621	T2620	amod	peripheral,system
R641	T2622	T2620	amod	nervous,system
R642	T2623	T2603	prep	in,reported
R643	T2624	T2625	npadvmod	Adam22,null
R644	T2674	T2672	pobj	brain,in
R645	T2625	T2627	amod	null,mice
R646	T2626	T2625	punct	-,null
R647	T2627	T2623	pobj	mice,in
R648	T2675	T2662	aux	has,observed
R649	T2628	T2627	compound	mutant,mice
R65	T639	T632	nsubj	we,generated
R650	T2629	T2630	punct	[,22
R651	T2630	T2603	parataxis	22,reported
R652	T2676	T2662	auxpass	been,observed
R653	T2631	T2630	punct	],22
R654	T2632	T2603	punct	.,reported
R655	T2677	T2662	prep	in,observed
R656	T2634	T2635	nsubjpass	It,reported
R657	T2678	T2679	preconj	either,mice
R658	T2679	T2677	pobj	mice,in
R659	T2680	T2681	npadvmod	Adam22,null
R66	T640	T641	npadvmod	ADAM11,deficient
R660	T2681	T2679	amod	null,mice
R661	T2682	T2681	punct	-,null
R662	T2683	T2681	cc	nor,null
R663	T2742	T2743	punct	[,24
R664	T2743	T2715	parataxis	24,reported
R665	T2684	T2685	npadvmod	Adam23,null
R666	T2744	T2743	punct	],24
R667	T2745	T2715	punct	;,reported
R668	T2685	T2681	conj	null,null
R669	T2746	T2715	cc	and,reported
R67	T641	T643	amod	deficient,mice
R670	T2747	T2748	nsubjpass	it,reported
R671	T2748	T2715	conj	reported,reported
R672	T2749	T2748	aux	has,reported
R673	T2686	T2685	punct	-,null
R674	T2750	T2748	auxpass	been,reported
R675	T2751	T2748	prep	in,reported
R676	T2687	T2662	punct	.,observed
R677	T2752	T2751	pobj	analyses,in
R678	T2753	T2752	acl	using,analyses
R679	T2689	T2690	nsubj	ADAM11,is
R68	T642	T641	punct	-,deficient
R680	T2754	T2755	nmod	Northern,blot
R681	T2755	T2756	nmod	blot,methods
R682	T2756	T2753	dobj	methods,using
R683	T2757	T2755	cc	and,blot
R684	T2691	T2692	det	the,paralog
R685	T2758	T2759	advmod	in,situ
R686	T2759	T2755	conj	situ,blot
R687	T2760	T2756	compound	hybridisation,methods
R688	T2761	T2762	mark	that,expressed
R689	T2692	T2690	attr	paralog,is
R69	T643	T632	dobj	mice,generated
R690	T2762	T2748	ccomp	expressed,reported
R691	T2763	T2764	det	the,gene
R692	T2764	T2762	nsubjpass	gene,expressed
R693	T2765	T2764	amod	murine,gene
R694	T2766	T2764	compound	Adam11,gene
R695	T2767	T2762	auxpass	is,expressed
R696	T2693	T2692	amod	closest,paralog
R697	T2768	T2762	prep	in,expressed
R698	T2769	T2770	preconj	both,system
R699	T2770	T2768	pobj	system,in
R7	T571	T572	compound	motor,coordination
R70	T644	T632	prep	by,generated
R700	T2694	T2692	prep	of,paralog
R701	T2771	T2770	det	the,system
R702	T2772	T2770	amod	developing,system
R703	T2773	T2772	cc	and,developing
R704	T2695	T2694	pobj	ADAM22,of
R705	T2774	T2772	conj	adult,developing
R706	T2775	T2770	amod	nervous,system
R707	T2696	T2695	cc	and,ADAM22
R708	T2776	T2777	punct	[,25
R709	T2777	T2748	parataxis	25,reported
R71	T645	T644	pobj	means,by
R710	T2778	T2777	nummod	19,25
R711	T2697	T2695	conj	ADAM23,ADAM22
R712	T2779	T2777	punct	",",25
R713	T2780	T2777	punct	],25
R714	T2781	T2748	punct	.,reported
R715	T2698	T2690	punct	", ",is
R716	T2783	T2784	det	These,findings
R717	T2784	T2785	nsubj	findings,led
R718	T2699	T2690	cc	and,is
R719	T2786	T2785	dobj	us,led
R72	T646	T645	prep	of,means
R720	T2700	T2701	poss	its,orthologs
R721	T2787	T2788	aux	to,hypothesise
R722	T2788	T2785	xcomp	hypothesise,led
R723	T2789	T2790	mark	that,is
R724	T2790	T2788	ccomp	is,hypothesise
R725	T2701	T2702	nsubjpass	orthologs,found
R726	T2791	T2790	nsubj	ADAM11,is
R727	T2792	T2793	det	an,binder
R728	T2702	T2690	conj	found,is
R729	T2703	T2702	aux	have,found
R73	T647	T648	compound	gene,targeting
R730	T2704	T2702	auxpass	been,found
R731	T2793	T2790	attr	binder,is
R732	T2705	T2702	prep	in,found
R733	T2794	T2793	compound	integrin,binder
R734	T2795	T2796	dep	that,plays
R735	T2796	T2793	relcl	plays,binder
R736	T2797	T2798	det	an,role
R737	T2706	T2705	pobj	vertebrates,in
R738	T2798	T2796	dobj	role,plays
R739	T2799	T2798	amod	important,role
R74	T648	T646	pobj	targeting,of
R740	T2800	T2796	prep	in,plays
R741	T2707	T2705	punct	", ",in
R742	T2801	T2802	det	the,system
R743	T2708	T2705	cc	but,in
R744	T2802	T2800	pobj	system,in
R745	T2803	T2802	amod	nervous,system
R746	T2804	T2796	punct	", ",plays
R747	T2805	T2806	mark	as,do
R748	T2806	T2796	advcl	do,plays
R749	T2807	T2806	nsubj	ADAM22,do
R75	T649	T632	punct	.,generated
R750	T2709	T2708	neg	not,but
R751	T2808	T2807	cc	and,ADAM22
R752	T2809	T2807	conj	ADAM23,ADAM22
R753	T2810	T2785	punct	.,led
R754	T2710	T2705	conj	in,in
R755	T2812	T2813	aux	To,determine
R756	T2813	T2814	advcl	determine,generated
R757	T2711	T2710	pobj	invertebrates,in
R758	T2815	T2816	det	the,functions
R759	T2816	T2813	dobj	functions,determine
R76	T653	T654	npadvmod	ADAM11,deficient
R760	T2712	T2702	punct	.,found
R761	T2817	T2816	amod	physiological,functions
R762	T2818	T2816	prep	of,functions
R763	T2714	T2715	nsubjpass	It,reported
R764	T2819	T2818	pobj	ADAM11,of
R765	T2820	T2814	punct	", ",generated
R766	T2821	T2814	nsubj	we,generated
R767	T2822	T2814	cc	and,generated
R768	T2823	T2814	conj	analysed,generated
R769	T2716	T2715	aux	has,reported
R77	T654	T656	amod	deficient,mice
R770	T2824	T2825	nmod	Adam11,mice
R771	T2825	T2823	dobj	mice,analysed
R772	T2826	T2827	npadvmod	gene,targeted
R773	T2717	T2715	auxpass	been,reported
R774	T2827	T2825	amod	targeted,mice
R775	T2828	T2827	punct	-,targeted
R776	T2829	T2814	punct	.,generated
R777	T2718	T2719	mark	that,has
R778	T2719	T2715	ccomp	has,reported
R779	T2720	T2721	det	the,ortholog
R78	T655	T654	punct	-,deficient
R780	T2721	T2719	nsubj	ortholog,has
R781	T2722	T2721	compound	Xenopus,ortholog
R782	T2723	T2721	compound	ADAM11,ortholog
R783	T2724	T2721	punct	", ",ortholog
R784	T2725	T2721	appos	xMDC11a,ortholog
R785	T2726	T2719	punct	", ",has
R786	T2727	T2728	det	an,pattern
R787	T2728	T2719	dobj	pattern,has
R788	T2729	T2728	compound	expression,pattern
R789	T2730	T2728	acl	associated,pattern
R79	T656	T657	nsubj	mice,were
R790	T2731	T2730	prep	with,associated
R791	T2732	T2733	amod	neural,development
R792	T2733	T2731	pobj	development,with
R793	T2734	T2728	punct	", ",pattern
R794	T2735	T2728	prep	with,pattern
R795	T2736	T2737	det	a,role
R796	T2737	T2735	pobj	role,with
R797	T2738	T2737	amod	proposed,role
R798	T2739	T2737	prep	in,role
R799	T2740	T2741	compound	cell,migration
R8	T573	T565	prep	in,Deficits
R80	T658	T657	advmod	apparently,were
R800	T2741	T2739	pobj	migration,in
R801	T3215	T3214	prep	of,Generation
R802	T3216	T3217	npadvmod	ADAM11,deficient
R803	T3217	T3219	amod	deficient,mice
R804	T3218	T3217	punct	-,deficient
R805	T3219	T3215	pobj	mice,of
R806	T3221	T3222	nsubjpass	Mice,generated
R807	T3223	T3221	acl	carrying,Mice
R808	T3224	T3225	det	a,mutation
R809	T3225	T3223	dobj	mutation,carrying
R81	T659	T657	acomp	normal,were
R810	T3226	T3225	amod	targeted,mutation
R811	T3227	T3223	prep	in,carrying
R812	T3228	T3229	poss	their,gene
R813	T3229	T3227	pobj	gene,in
R814	T3230	T3229	compound	Adam11,gene
R815	T3231	T3222	auxpass	were,generated
R816	T3232	T3222	prep	by,generated
R817	T3233	T3234	amod	homologous,recombination
R818	T3234	T3232	pobj	recombination,by
R819	T3235	T3236	punct	(,1A
R82	T660	T657	punct	", ",were
R820	T3236	T3222	parataxis	1A,generated
R821	T3237	T3236	compound	Fig.,1A
R822	T3238	T3236	punct	),1A
R823	T3239	T3222	punct	.,generated
R824	T3241	T3242	amod	Correct,events
R825	T3242	T3244	nsubjpass	events,confirmed
R826	T3243	T3242	compound	targeting,events
R827	T3245	T3244	auxpass	were,confirmed
R828	T3246	T3244	agent	by,confirmed
R829	T3247	T3248	compound	Southern,blot
R83	T661	T657	cc	and,were
R830	T3248	T3249	compound	blot,analysis
R831	T3249	T3246	pobj	analysis,by
R832	T3250	T3251	punct	(,1B
R833	T3251	T3244	parataxis	1B,confirmed
R834	T3252	T3251	compound	Fig.,1B
R835	T3253	T3251	punct	),1B
R836	T3254	T3244	punct	.,confirmed
R837	T3256	T3257	prep	As,synthesised
R838	T3258	T3259	det	a,result
R839	T3259	T3256	pobj	result,As
R84	T662	T657	conj	survived,were
R840	T3260	T3259	prep	of,result
R841	T3261	T3262	det	this,procedure
R842	T3262	T3260	pobj	procedure,of
R843	T3263	T3257	punct	", ",synthesised
R844	T3264	T3265	mark	since,introduced
R845	T3265	T3257	advcl	introduced,synthesised
R846	T3266	T3267	det	a,codon
R847	T3267	T3265	nsubjpass	codon,introduced
R848	T3268	T3267	compound	termination,codon
R849	T3269	T3265	auxpass	was,introduced
R85	T663	T664	amod	more,one
R850	T3270	T3265	prep	in,introduced
R851	T3271	T3270	pobj	exon,in
R852	T3272	T3271	nummod	5,exon
R853	T3273	T3265	prep	in,introduced
R854	T3274	T3275	det	the,domain
R855	T3275	T3273	pobj	domain,in
R856	T3276	T3275	amod	pro-protein,domain
R857	T3277	T3257	punct	", ",synthesised
R858	T3278	T3279	advmod	only,form
R859	T3279	T3257	nsubjpass	form,synthesised
R86	T664	T666	nummod	one,year
R860	T3280	T3279	det	the,form
R861	T3281	T3279	amod	truncated,form
R862	T3282	T3279	prep	of,form
R863	T3283	T3284	det	the,protein
R864	T3284	T3282	pobj	protein,of
R865	T3285	T3284	compound	ADAM11,protein
R866	T3286	T3257	aux	would,synthesised
R867	T3287	T3257	auxpass	be,synthesised
R868	T3288	T3257	prep	from,synthesised
R869	T3289	T3290	det	this,allele
R87	T665	T664	quantmod	than,one
R870	T3290	T3288	pobj	allele,from
R871	T3291	T3290	amod	targeted,allele
R872	T3292	T3257	punct	.,synthesised
R873	T3294	T3295	mark	Because,removed
R874	T3295	T3300	advcl	removed,concluded
R875	T3296	T3297	amod	pro-protein,domains
R876	T3297	T3295	nsubjpass	domains,removed
R877	T3298	T3295	auxpass	are,removed
R878	T3299	T3295	advmod	always,removed
R879	T3301	T3295	prep	in,removed
R88	T666	T662	npadvmod	year,survived
R880	T3302	T3303	amod	mature,proteins
R881	T3303	T3301	pobj	proteins,in
R882	T3304	T3303	amod	functional,proteins
R883	T3305	T3303	compound	ADAM,proteins
R884	T3306	T3303	punct	-,proteins
R885	T3307	T3295	agent	by,removed
R886	T3308	T3309	npadvmod	furin,like
R887	T3309	T3311	amod	like,proteases
R888	T3310	T3309	punct	-,like
R889	T3311	T3307	pobj	proteases,by
R89	T667	T662	prep	with,survived
R890	T3312	T3295	cc	and,removed
R891	T3313	T3314	auxpass	are,thought
R892	T3314	T3295	conj	thought,removed
R893	T3315	T3314	advmod	thus,thought
R894	T3316	T3317	aux	to,be
R895	T3317	T3314	xcomp	be,thought
R896	T3318	T3317	acomp	non-functional,be
R897	T3319	T3300	punct	", ",concluded
R898	T3320	T3300	nsubj	we,concluded
R899	T3321	T3322	mark	that,have
R9	T574	T575	npadvmod	ADAM11,deficient
R90	T668	T669	det	no,abnormalities
R900	T3322	T3300	ccomp	have,concluded
R901	T3323	T3324	det	this,form
R902	T3324	T3322	nsubj	form,have
R903	T3325	T3324	amod	truncated,form
R904	T3326	T3324	prep	of,form
R905	T3327	T3328	compound	ADAM11,protein
R906	T3328	T3326	pobj	protein,of
R907	T3329	T3322	aux	would,have
R908	T3330	T3331	det	no,function
R909	T3331	T3322	dobj	function,have
R91	T669	T667	pobj	abnormalities,with
R910	T3332	T3333	punct	[,26
R911	T3333	T3322	parataxis	26,have
R912	T3334	T3333	punct	],26
R913	T3335	T3300	punct	.,concluded
R914	T3337	T3338	nsubjpass	Absence,confirmed
R915	T3339	T3337	prep	of,Absence
R916	T3340	T3341	amod	mature,protein
R917	T3341	T3339	pobj	protein,of
R918	T3342	T3341	compound	ADAM11,protein
R919	T3343	T3337	prep	in,Absence
R92	T670	T669	amod	major,abnormalities
R920	T3344	T3345	amod	homozygous,mutants
R921	T3345	T3343	pobj	mutants,in
R922	T3346	T3338	auxpass	was,confirmed
R923	T3347	T3338	prep	by,confirmed
R924	T3348	T3349	compound	Western,blot
R925	T3349	T3350	compound	blot,analysis
R926	T3350	T3347	pobj	analysis,by
R927	T3351	T3350	acl	using,analysis
R928	T3352	T3353	det	a,antibody
R929	T3353	T3351	dobj	antibody,using
R93	T671	T669	amod	histological,abnormalities
R930	T3354	T3353	amod	specific,antibody
R931	T3355	T3356	dep	that,recognises
R932	T3356	T3353	relcl	recognises,antibody
R933	T3357	T3358	det	the,protein
R934	T3358	T3356	dobj	protein,recognises
R935	T3359	T3358	compound	ADAM11,protein
R936	T3360	T3361	punct	(,1C
R937	T3361	T3338	parataxis	1C,confirmed
R938	T3362	T3361	compound	Fig.,1C
R939	T3363	T3361	punct	),1C
R94	T672	T669	prep	in,abnormalities
R940	T3364	T3338	punct	.,confirmed
R941	T3366	T3367	nsubj	Analysis,showed
R942	T3368	T3366	prep	by,Analysis
R943	T3369	T3370	compound	Western,blot
R944	T3370	T3368	pobj	blot,by
R945	T3371	T3372	mark	that,produced
R946	T3372	T3367	ccomp	produced,showed
R947	T3373	T3374	amod	heterozygous,mutants
R948	T3374	T3372	nsubj	mutants,produced
R949	T3375	T3376	advmod	approximately,half
R95	T673	T674	det	the,brain
R950	T3376	T3372	dobj	half,produced
R951	T3377	T3376	prep	of,half
R952	T3378	T3379	det	the,levels
R953	T3379	T3377	pobj	levels,of
R954	T3380	T3381	amod	wild,type
R955	T3381	T3379	compound	type,levels
R956	T3382	T3381	punct	-,type
R957	T3383	T3379	prep	of,levels
R958	T3384	T3385	compound	ADAM11,protein
R959	T3385	T3383	pobj	protein,of
R96	T674	T672	pobj	brain,in
R960	T3386	T3367	punct	.,showed
R961	T3987	T3988	npadvmod	ADAM11,deficient
R962	T3988	T3990	amod	deficient,mice
R963	T3989	T3988	punct	-,deficient
R964	T3990	T3991	nsubj	mice,are
R965	T3992	T3991	acomp	viable,are
R966	T3993	T3991	cc	and,are
R967	T3994	T3991	conj	appear,are
R968	T3995	T3994	oprd	normal,appear
R969	T3997	T3998	nsubj	Mating,yielded
R97	T675	T674	cc	or,brain
R970	T3999	T3997	prep	of,Mating
R971	T4000	T3999	pobj	mice,of
R972	T4001	T4000	amod	heterozygous,mice
R973	T4002	T4001	prep	for,heterozygous
R974	T4003	T4004	det	the,mutation
R975	T4004	T4002	pobj	mutation,for
R976	T4005	T4004	compound	ADAM11,mutation
R977	T4006	T4007	det	a,distribution
R978	T4007	T3998	dobj	distribution,yielded
R979	T4008	T4009	amod	near,Mendelian
R98	T676	T677	amod	spinal,cord
R980	T4009	T4007	amod	Mendelian,distribution
R981	T4010	T4009	punct	-,Mendelian
R982	T4011	T4007	prep	of,distribution
R983	T4012	T4011	pobj	genotypes,of
R984	T4013	T3998	prep	in,yielded
R985	T4014	T4015	det	the,offspring
R986	T4015	T4013	pobj	offspring,in
R987	T4016	T3998	cc	and,yielded
R988	T4017	T4018	det	the,ratio
R989	T4018	T4019	nsubj	ratio,was
R99	T677	T674	conj	cord,brain
R990	T4019	T3998	conj	was,yielded
R991	T4020	T4018	prep	of,ratio
R992	T4021	T4020	pobj	females,of
R993	T4022	T4021	cc	and,females
R994	T4023	T4021	conj	males,females
R995	T4024	T4025	det	the,same
R996	T4025	T4019	attr	same,was
R997	T4026	T4019	prep	in,was
R998	T4027	T4028	det	all,groups
R999	T4028	T4026	pobj	groups,in

PMC:1420314 JSONTXT 7 Projects

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PMC:1420314 JSON TXT 7 Projects