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PMC:1420271 / 1853-4218 JSONTXT 4 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T2208 11-20 JJ denotes Embryonic
T2209 21-25 NN denotes stem
T2211 26-27 -LRB- denotes (
T2212 27-29 NN denotes ES
T2213 29-30 -RRB- denotes )
T2210 31-36 NNS denotes cells
T2215 37-41 VBD denotes were
T2216 42-47 RB denotes first
T2214 48-55 VBN denotes derived
T2217 56-60 IN denotes from
T2218 61-64 DT denotes the
T2219 65-76 NNS denotes blastocysts
T2220 77-79 IN denotes of
T2221 80-84 NNS denotes mice
T2222 85-87 IN denotes in
T2223 88-92 CD denotes 1981
T2224 93-94 -LRB- denotes [
T2226 94-95 CD denotes 1
T2227 95-96 , denotes ,
T2225 96-97 CD denotes 2
T2228 97-98 -RRB- denotes ]
T2229 99-102 CC denotes and
T2230 103-109 NNS denotes humans
T2231 110-112 IN denotes in
T2232 113-117 CD denotes 1998
T2233 118-119 -LRB- denotes [
T2234 119-120 CD denotes 3
T2235 120-121 -RRB- denotes ]
T2236 121-122 . denotes .
T2237 122-292 sentence denotes ES cells have two important properties: theability to maintain pluripotency, which is the ability to differentiate into a wide variety of cells, and rapid proliferation.
T2238 123-125 NN denotes ES
T2239 126-131 NNS denotes cells
T2240 132-136 VBP denotes have
T2241 137-140 CD denotes two
T2243 141-150 JJ denotes important
T2242 151-161 NNS denotes properties
T2244 161-163 : denotes :
T2245 163-173 NN denotes theability
T2246 174-176 TO denotes to
T2247 177-185 VB denotes maintain
T2248 186-198 NN denotes pluripotency
T2249 198-200 , denotes ,
T2250 200-205 WDT denotes which
T2251 206-208 VBZ denotes is
T2252 209-212 DT denotes the
T2253 213-220 NN denotes ability
T2254 221-223 TO denotes to
T2255 224-237 VB denotes differentiate
T2256 238-242 IN denotes into
T2257 243-244 DT denotes a
T2259 245-249 JJ denotes wide
T2258 250-257 NN denotes variety
T2260 258-260 IN denotes of
T2261 261-266 NNS denotes cells
T2262 266-268 , denotes ,
T2263 268-271 CC denotes and
T2264 272-277 JJ denotes rapid
T2265 278-291 NN denotes proliferation
T2266 291-292 . denotes .
T2267 292-387 sentence denotes These characteristics make mouse ES cells an essential component of gene targeting technology.
T2268 293-298 DT denotes These
T2269 299-314 NNS denotes characteristics
T2270 315-319 VBP denotes make
T2271 320-325 NN denotes mouse
T2273 326-328 NN denotes ES
T2272 329-334 NNS denotes cells
T2275 335-337 DT denotes an
T2276 338-347 JJ denotes essential
T2274 348-357 NN denotes component
T2277 358-360 IN denotes of
T2278 361-365 NN denotes gene
T2279 366-375 NN denotes targeting
T2280 376-386 NN denotes technology
T2281 386-387 . denotes .
T2282 387-560 sentence denotes These qualitiesalso make human ES cells attractive sources for cell transplantation therapy to treat various diseases, including spinal cord injuries and juvenile diabetes.
T2283 388-393 DT denotes These
T2284 394-403 NNS denotes qualities
T2286 403-407 RB denotes also
T2285 408-412 VBP denotes make
T2287 413-418 JJ denotes human
T2289 419-421 NN denotes ES
T2288 422-427 NNS denotes cells
T2291 428-438 JJ denotes attractive
T2290 439-446 NNS denotes sources
T2292 447-450 IN denotes for
T2293 451-455 NN denotes cell
T2294 456-471 NN denotes transplantation
T2295 472-479 NN denotes therapy
T2296 480-482 TO denotes to
T2297 483-488 VB denotes treat
T2298 489-496 JJ denotes various
T2299 497-505 NNS denotes diseases
T2300 505-507 , denotes ,
T2301 507-516 VBG denotes including
T2302 517-523 JJ denotes spinal
T2303 524-528 NN denotes cord
T2304 529-537 NNS denotes injuries
T2305 538-541 CC denotes and
T2306 542-550 JJ denotes juvenile
T2307 551-559 NN denotes diabetes
T2308 559-560 . denotes .
T2309 560-718 sentence denotes The molecular mechanisms underlying the pluripotency and rapid proliferation of ES cells are currently a major focus of the field of stem cell biology [4-6].
T2310 561-564 DT denotes The
T2312 565-574 JJ denotes molecular
T2311 575-585 NNS denotes mechanisms
T2314 586-596 VBG denotes underlying
T2315 597-600 DT denotes the
T2316 601-613 NN denotes pluripotency
T2317 614-617 CC denotes and
T2318 618-623 JJ denotes rapid
T2319 624-637 NN denotes proliferation
T2320 638-640 IN denotes of
T2321 641-643 NN denotes ES
T2322 644-649 NNS denotes cells
T2313 650-653 VBP denotes are
T2323 654-663 RB denotes currently
T2324 664-665 DT denotes a
T2326 666-671 JJ denotes major
T2325 672-677 NN denotes focus
T2327 678-680 IN denotes of
T2328 681-684 DT denotes the
T2329 685-690 NN denotes field
T2330 691-693 IN denotes of
T2331 694-698 NN denotes stem
T2332 699-703 NN denotes cell
T2333 704-711 NN denotes biology
T2334 712-713 -LRB- denotes [
T2335 713-714 CD denotes 4
T2336 714-715 SYM denotes -
T2337 715-716 CD denotes 6
T2338 716-717 -RRB- denotes ]
T2339 717-718 . denotes .
T2340 718-908 sentence denotes To identify molecules essential in ES cells for these properties, several groups have utilized transcriptome analyses to identify genes specifically expressed in ES cells and early embryos.
T2341 719-721 TO denotes To
T2342 722-730 VB denotes identify
T2344 731-740 NNS denotes molecules
T2345 741-750 JJ denotes essential
T2346 751-753 IN denotes in
T2347 754-756 NN denotes ES
T2348 757-762 NNS denotes cells
T2349 763-766 IN denotes for
T2350 767-772 DT denotes these
T2351 773-783 NNS denotes properties
T2352 783-785 , denotes ,
T2353 785-792 JJ denotes several
T2354 793-799 NNS denotes groups
T2355 800-804 VBP denotes have
T2343 805-813 VBN denotes utilized
T2356 814-827 NN denotes transcriptome
T2357 828-836 NNS denotes analyses
T2358 837-839 TO denotes to
T2359 840-848 VB denotes identify
T2360 849-854 NNS denotes genes
T2361 855-867 RB denotes specifically
T2362 868-877 VBN denotes expressed
T2363 878-880 IN denotes in
T2364 881-883 NN denotes ES
T2365 884-889 NNS denotes cells
T2366 890-893 CC denotes and
T2367 894-899 JJ denotes early
T2368 900-907 NNS denotes embryos
T2369 907-908 . denotes .
T2370 908-1101 sentence denotes These analyses, including DNA microarray analyses [7] and expressed sequence tag analyses [8-12], identified several common transcripts, including ESG1 that was also designated dppa5 or ECAT2.
T2371 909-914 DT denotes These
T2372 915-923 NNS denotes analyses
T2374 923-925 , denotes ,
T2375 925-934 VBG denotes including
T2376 935-938 NN denotes DNA
T2378 939-949 NN denotes microarray
T2377 950-958 NNS denotes analyses
T2379 959-960 -LRB- denotes [
T2380 960-961 CD denotes 7
T2381 961-962 -RRB- denotes ]
T2382 963-966 CC denotes and
T2383 967-976 VBN denotes expressed
T2384 977-985 NN denotes sequence
T2386 986-989 NN denotes tag
T2385 990-998 NNS denotes analyses
T2387 999-1000 -LRB- denotes [
T2388 1000-1001 CD denotes 8
T2389 1001-1002 SYM denotes -
T2390 1002-1004 CD denotes 12
T2391 1004-1005 -RRB- denotes ]
T2392 1005-1007 , denotes ,
T2373 1007-1017 VBD denotes identified
T2393 1018-1025 JJ denotes several
T2395 1026-1032 JJ denotes common
T2394 1033-1044 NNS denotes transcripts
T2396 1044-1046 , denotes ,
T2397 1046-1055 VBG denotes including
T2398 1056-1060 NN denotes ESG1
T2399 1061-1065 WDT denotes that
T2401 1066-1069 VBD denotes was
T2402 1070-1074 RB denotes also
T2400 1075-1085 VBN denotes designated
T2403 1086-1091 NN denotes dppa5
T2404 1092-1094 CC denotes or
T2405 1095-1100 NN denotes ECAT2
T2406 1100-1101 . denotes .
T2407 1101-1229 sentence denotes ESG1 was originally identified as a transcript Ph34 that was down-regulated by retinoic acid in embryonic carcinoma cells [13].
T2408 1102-1106 NN denotes ESG1
T2410 1107-1110 VBD denotes was
T2411 1111-1121 RB denotes originally
T2409 1122-1132 VBN denotes identified
T2412 1133-1135 IN denotes as
T2413 1136-1137 DT denotes a
T2415 1138-1148 NN denotes transcript
T2414 1149-1153 NN denotes Ph34
T2416 1154-1158 WDT denotes that
T2418 1159-1162 VBD denotes was
T2419 1163-1167 RB denotes down
T2420 1167-1168 HYPH denotes -
T2417 1168-1177 VBN denotes regulated
T2421 1178-1180 IN denotes by
T2422 1181-1189 JJ denotes retinoic
T2423 1190-1194 NN denotes acid
T2424 1195-1197 IN denotes in
T2425 1198-1207 JJ denotes embryonic
T2426 1208-1217 NN denotes carcinoma
T2427 1218-1223 NNS denotes cells
T2428 1224-1225 -LRB- denotes [
T2429 1225-1227 CD denotes 13
T2430 1227-1228 -RRB- denotes ]
T2431 1228-1229 . denotes .
T2432 1229-1316 sentence denotes The expression of this gene was confined in mice to early embryos and germ cells [14].
T2433 1230-1233 DT denotes The
T2434 1234-1244 NN denotes expression
T2436 1245-1247 IN denotes of
T2437 1248-1252 DT denotes this
T2438 1253-1257 NN denotes gene
T2439 1258-1261 VBD denotes was
T2435 1262-1270 VBN denotes confined
T2440 1271-1273 IN denotes in
T2441 1274-1278 NNS denotes mice
T2442 1279-1281 IN denotes to
T2443 1282-1287 JJ denotes early
T2444 1288-1295 NNS denotes embryos
T2445 1296-1299 CC denotes and
T2446 1300-1304 NN denotes germ
T2447 1305-1310 NNS denotes cells
T2448 1311-1312 -LRB- denotes [
T2449 1312-1314 CD denotes 14
T2450 1314-1315 -RRB- denotes ]
T2451 1315-1316 . denotes .
T2452 1316-1443 sentence denotes It is also expressed in pluripotent cells, including ES cells, embryonic germ cells, and multipotent germline stem cells [15].
T2453 1317-1319 PRP denotes It
T2455 1320-1322 VBZ denotes is
T2456 1323-1327 RB denotes also
T2454 1328-1337 VBN denotes expressed
T2457 1338-1340 IN denotes in
T2458 1341-1352 JJ denotes pluripotent
T2459 1353-1358 NNS denotes cells
T2460 1358-1360 , denotes ,
T2461 1360-1369 VBG denotes including
T2462 1370-1372 NN denotes ES
T2463 1373-1378 NNS denotes cells
T2464 1378-1380 , denotes ,
T2465 1380-1389 JJ denotes embryonic
T2467 1390-1394 NN denotes germ
T2466 1395-1400 NNS denotes cells
T2468 1400-1402 , denotes ,
T2469 1402-1405 CC denotes and
T2470 1406-1417 JJ denotes multipotent
T2472 1418-1426 NN denotes germline
T2473 1427-1431 NN denotes stem
T2471 1432-1437 NNS denotes cells
T2474 1438-1439 -LRB- denotes [
T2475 1439-1441 CD denotes 15
T2476 1441-1442 -RRB- denotes ]
T2477 1442-1443 . denotes .
T2478 1443-1560 sentence denotes ESG1 encodes a polypeptide of 118 amino acids that contains a single KH domain, which is an RNA-binding domain [16].
T2479 1444-1448 NN denotes ESG1
T2480 1449-1456 VBZ denotes encodes
T2481 1457-1458 DT denotes a
T2482 1459-1470 NN denotes polypeptide
T2483 1471-1473 IN denotes of
T2484 1474-1477 CD denotes 118
T2486 1478-1483 NN denotes amino
T2485 1484-1489 NNS denotes acids
T2487 1490-1494 WDT denotes that
T2488 1495-1503 VBZ denotes contains
T2489 1504-1505 DT denotes a
T2491 1506-1512 JJ denotes single
T2492 1513-1515 NN denotes KH
T2490 1516-1522 NN denotes domain
T2493 1522-1524 , denotes ,
T2494 1524-1529 WDT denotes which
T2495 1530-1532 VBZ denotes is
T2496 1533-1535 DT denotes an
T2498 1536-1539 NN denotes RNA
T2500 1539-1540 HYPH denotes -
T2499 1540-1547 VBG denotes binding
T2497 1548-1554 NN denotes domain
T2501 1555-1556 -LRB- denotes [
T2502 1556-1558 CD denotes 16
T2503 1558-1559 -RRB- denotes ]
T2504 1559-1560 . denotes .
T2505 1560-1677 sentence denotes It remains unclear, however, if ESG1 functions as an RNA-binding protein or the roles it plays in ES cells and mice.
T2506 1561-1563 PRP denotes It
T2507 1564-1571 VBZ denotes remains
T2508 1572-1579 JJ denotes unclear
T2509 1579-1581 , denotes ,
T2510 1581-1588 RB denotes however
T2511 1588-1590 , denotes ,
T2512 1590-1592 IN denotes if
T2514 1593-1597 NN denotes ESG1
T2513 1598-1607 VBZ denotes functions
T2515 1608-1610 IN denotes as
T2516 1611-1613 DT denotes an
T2518 1614-1617 NN denotes RNA
T2520 1617-1618 HYPH denotes -
T2519 1618-1625 VBG denotes binding
T2517 1626-1633 NN denotes protein
T2521 1634-1636 CC denotes or
T2522 1637-1640 DT denotes the
T2523 1641-1646 NNS denotes roles
T2524 1647-1649 PRP denotes it
T2525 1650-1655 VBZ denotes plays
T2526 1656-1658 IN denotes in
T2527 1659-1661 NN denotes ES
T2528 1662-1667 NNS denotes cells
T2529 1668-1671 CC denotes and
T2530 1672-1676 NNS denotes mice
T2531 1676-1677 . denotes .
T2532 1677-1800 sentence denotes Previous genomic library screening by identified genomic clones containing the mouse ESG1 gene and seven pseudogenes [17].
T2533 1678-1686 JJ denotes Previous
T2535 1687-1694 JJ denotes genomic
T2536 1695-1702 NN denotes library
T2534 1703-1712 NN denotes screening
T2537 1713-1715 IN denotes by
T2538 1716-1726 VBN denotes identified
T2540 1727-1734 JJ denotes genomic
T2539 1735-1741 NNS denotes clones
T2541 1742-1752 VBG denotes containing
T2542 1753-1756 DT denotes the
T2544 1757-1762 NN denotes mouse
T2545 1763-1767 NN denotes ESG1
T2543 1768-1772 NN denotes gene
T2546 1773-1776 CC denotes and
T2547 1777-1782 CD denotes seven
T2548 1783-1794 NNS denotes pseudogenes
T2549 1795-1796 -LRB- denotes [
T2550 1796-1798 CD denotes 17
T2551 1798-1799 -RRB- denotes ]
T2552 1799-1800 . denotes .
T2553 1800-1932 sentence denotes Two of these pseudogenes exhibit a similar exon-intron structure as the ESG1 gene, indicating their generation by gene duplication.
T2554 1801-1804 CD denotes Two
T2556 1805-1807 IN denotes of
T2557 1808-1813 DT denotes these
T2558 1814-1825 NNS denotes pseudogenes
T2555 1826-1833 VBP denotes exhibit
T2559 1834-1835 DT denotes a
T2561 1836-1843 JJ denotes similar
T2562 1844-1848 NN denotes exon
T2564 1848-1849 HYPH denotes -
T2563 1849-1855 NN denotes intron
T2560 1856-1865 NN denotes structure
T2565 1866-1868 IN denotes as
T2566 1869-1872 DT denotes the
T2568 1873-1877 NN denotes ESG1
T2567 1878-1882 NN denotes gene
T2569 1882-1884 , denotes ,
T2570 1884-1894 VBG denotes indicating
T2571 1895-1900 PRP$ denotes their
T2572 1901-1911 NN denotes generation
T2573 1912-1914 IN denotes by
T2574 1915-1919 NN denotes gene
T2575 1920-1931 NN denotes duplication
T2576 1931-1932 . denotes .
T2577 1932-2072 sentence denotes The five remaining pseudogenes did not contain any introns, indicating that these were generated by retrotransposition of ESG1 transcripts.
T2578 1933-1936 DT denotes The
T2580 1937-1941 CD denotes five
T2581 1942-1951 VBG denotes remaining
T2579 1952-1963 NNS denotes pseudogenes
T2583 1964-1967 VBD denotes did
T2584 1968-1971 RB denotes not
T2582 1972-1979 VB denotes contain
T2585 1980-1983 DT denotes any
T2586 1984-1991 NNS denotes introns
T2587 1991-1993 , denotes ,
T2588 1993-2003 VBG denotes indicating
T2589 2004-2008 IN denotes that
T2591 2009-2014 DT denotes these
T2592 2015-2019 VBD denotes were
T2590 2020-2029 VBN denotes generated
T2593 2030-2032 IN denotes by
T2594 2033-2051 NN denotes retrotransposition
T2595 2052-2054 IN denotes of
T2596 2055-2059 NN denotes ESG1
T2597 2060-2071 NNS denotes transcripts
T2598 2071-2072 . denotes .
T2599 2072-2175 sentence denotes The chromosomal localizations of the mouse ESG1 gene and pseudogenes, however, have not been reported.
T2600 2073-2076 DT denotes The
T2602 2077-2088 JJ denotes chromosomal
T2601 2089-2102 NNS denotes localizations
T2604 2103-2105 IN denotes of
T2605 2106-2109 DT denotes the
T2607 2110-2115 NN denotes mouse
T2608 2116-2120 NN denotes ESG1
T2606 2121-2125 NN denotes gene
T2609 2126-2129 CC denotes and
T2610 2130-2141 NNS denotes pseudogenes
T2611 2141-2143 , denotes ,
T2612 2143-2150 RB denotes however
T2613 2150-2152 , denotes ,
T2614 2152-2156 VBP denotes have
T2615 2157-2160 RB denotes not
T2616 2161-2165 VBN denotes been
T2603 2166-2174 VBN denotes reported
T2617 2174-2175 . denotes .
T2618 2175-2283 sentence denotes In this study, we determined the structure of the mouse gene encoding this protein and related pseudogenes.
T2619 2176-2178 IN denotes In
T2621 2179-2183 DT denotes this
T2622 2184-2189 NN denotes study
T2623 2189-2191 , denotes ,
T2624 2191-2193 PRP denotes we
T2620 2194-2204 VBD denotes determined
T2625 2205-2208 DT denotes the
T2626 2209-2218 NN denotes structure
T2627 2219-2221 IN denotes of
T2628 2222-2225 DT denotes the
T2630 2226-2231 NN denotes mouse
T2629 2232-2236 NN denotes gene
T2631 2237-2245 VBG denotes encoding
T2632 2246-2250 DT denotes this
T2633 2251-2258 NN denotes protein
T2634 2259-2262 CC denotes and
T2635 2263-2270 JJ denotes related
T2636 2271-2282 NNS denotes pseudogenes
T2637 2282-2283 . denotes .
T2638 2283-2365 sentence denotes We also performed gene targeting to determine the physiological function of ESG1.
T2639 2284-2286 PRP denotes We
T2641 2287-2291 RB denotes also
T2640 2292-2301 VBD denotes performed
T2642 2302-2306 NN denotes gene
T2643 2307-2316 NN denotes targeting
T2644 2317-2319 TO denotes to
T2645 2320-2329 VB denotes determine
T2646 2330-2333 DT denotes the
T2648 2334-2347 JJ denotes physiological
T2647 2348-2356 NN denotes function
T2649 2357-2359 IN denotes of
T2650 2360-2364 NN denotes ESG1
T2651 2364-2365 . denotes .
R325 T2208 T2209 amod Embryonic,stem
R326 T2209 T2210 nmod stem,cells
R327 T2210 T2214 nsubjpass cells,derived
R328 T2211 T2209 punct (,stem
R329 T2212 T2209 appos ES,stem
R330 T2213 T2210 punct ),cells
R331 T2215 T2214 auxpass were,derived
R332 T2216 T2214 advmod first,derived
R333 T2217 T2214 prep from,derived
R334 T2218 T2219 det the,blastocysts
R335 T2219 T2217 pobj blastocysts,from
R336 T2220 T2219 prep of,blastocysts
R337 T2221 T2220 pobj mice,of
R338 T2222 T2214 prep in,derived
R339 T2223 T2222 pobj 1981,in
R340 T2224 T2225 punct [,2
R341 T2225 T2223 parataxis 2,1981
R342 T2226 T2225 nummod 1,2
R343 T2227 T2225 punct ",",2
R344 T2228 T2225 punct ],2
R345 T2229 T2214 cc and,derived
R346 T2230 T2214 conj humans,derived
R347 T2231 T2230 prep in,humans
R348 T2232 T2231 pobj 1998,in
R349 T2233 T2234 punct [,3
R350 T2234 T2232 parataxis 3,1998
R351 T2235 T2234 punct ],3
R352 T2236 T2214 punct .,derived
R353 T2238 T2239 compound ES,cells
R354 T2239 T2240 nsubj cells,have
R355 T2241 T2242 nummod two,properties
R356 T2242 T2240 dobj properties,have
R357 T2243 T2242 amod important,properties
R358 T2244 T2242 punct : ,properties
R359 T2245 T2242 appos theability,properties
R360 T2246 T2247 aux to,maintain
R361 T2247 T2245 acl maintain,theability
R362 T2248 T2247 dobj pluripotency,maintain
R363 T2249 T2248 punct ", ",pluripotency
R364 T2250 T2251 dep which,is
R365 T2251 T2248 relcl is,pluripotency
R366 T2252 T2253 det the,ability
R367 T2253 T2251 attr ability,is
R368 T2254 T2255 aux to,differentiate
R369 T2255 T2253 acl differentiate,ability
R370 T2256 T2255 prep into,differentiate
R371 T2257 T2258 det a,variety
R372 T2258 T2256 pobj variety,into
R373 T2259 T2258 amod wide,variety
R374 T2260 T2258 prep of,variety
R375 T2261 T2260 pobj cells,of
R376 T2262 T2245 punct ", ",theability
R377 T2263 T2245 cc and,theability
R378 T2264 T2265 amod rapid,proliferation
R379 T2265 T2245 conj proliferation,theability
R380 T2266 T2240 punct .,have
R381 T2268 T2269 det These,characteristics
R382 T2269 T2270 nsubj characteristics,make
R383 T2271 T2272 compound mouse,cells
R384 T2272 T2274 nsubj cells,component
R385 T2273 T2272 compound ES,cells
R386 T2274 T2270 ccomp component,make
R387 T2275 T2274 det an,component
R388 T2276 T2274 amod essential,component
R389 T2277 T2274 prep of,component
R390 T2278 T2279 compound gene,targeting
R391 T2279 T2280 compound targeting,technology
R392 T2280 T2277 pobj technology,of
R393 T2281 T2270 punct .,make
R394 T2283 T2284 det These,qualities
R395 T2284 T2285 nsubj qualities,make
R396 T2286 T2285 advmod also,make
R397 T2287 T2288 amod human,cells
R398 T2288 T2290 nsubj cells,sources
R399 T2289 T2288 compound ES,cells
R400 T2290 T2285 ccomp sources,make
R401 T2291 T2290 amod attractive,sources
R402 T2292 T2290 prep for,sources
R403 T2293 T2294 compound cell,transplantation
R404 T2294 T2295 compound transplantation,therapy
R405 T2295 T2292 pobj therapy,for
R406 T2296 T2297 aux to,treat
R407 T2297 T2295 advcl treat,therapy
R408 T2298 T2299 amod various,diseases
R409 T2299 T2297 dobj diseases,treat
R410 T2300 T2299 punct ", ",diseases
R411 T2301 T2299 prep including,diseases
R412 T2302 T2303 amod spinal,cord
R413 T2303 T2304 compound cord,injuries
R414 T2304 T2301 pobj injuries,including
R415 T2305 T2304 cc and,injuries
R416 T2306 T2307 amod juvenile,diabetes
R417 T2307 T2304 conj diabetes,injuries
R418 T2308 T2285 punct .,make
R419 T2310 T2311 det The,mechanisms
R420 T2311 T2313 nsubj mechanisms,are
R421 T2312 T2311 amod molecular,mechanisms
R422 T2314 T2311 acl underlying,mechanisms
R423 T2315 T2316 det the,pluripotency
R424 T2316 T2314 dobj pluripotency,underlying
R425 T2317 T2316 cc and,pluripotency
R426 T2318 T2319 amod rapid,proliferation
R427 T2319 T2316 conj proliferation,pluripotency
R428 T2320 T2316 prep of,pluripotency
R429 T2321 T2322 compound ES,cells
R430 T2322 T2320 pobj cells,of
R431 T2323 T2313 advmod currently,are
R432 T2324 T2325 det a,focus
R433 T2325 T2313 attr focus,are
R434 T2326 T2325 amod major,focus
R435 T2327 T2325 prep of,focus
R436 T2328 T2329 det the,field
R437 T2329 T2327 pobj field,of
R438 T2330 T2329 prep of,field
R439 T2331 T2332 compound stem,cell
R440 T2332 T2333 compound cell,biology
R441 T2333 T2330 pobj biology,of
R442 T2334 T2335 punct [,4
R443 T2335 T2313 parataxis 4,are
R444 T2336 T2337 punct -,6
R445 T2337 T2335 prep 6,4
R446 T2338 T2335 punct ],4
R447 T2339 T2313 punct .,are
R448 T2341 T2342 aux To,identify
R449 T2342 T2343 advcl identify,utilized
R450 T2344 T2342 dobj molecules,identify
R451 T2345 T2344 relcl essential,molecules
R452 T2346 T2345 prep in,essential
R453 T2347 T2348 compound ES,cells
R454 T2348 T2346 pobj cells,in
R455 T2349 T2345 prep for,essential
R456 T2350 T2351 det these,properties
R457 T2351 T2349 pobj properties,for
R458 T2352 T2343 punct ", ",utilized
R459 T2353 T2354 amod several,groups
R460 T2354 T2343 nsubj groups,utilized
R461 T2355 T2343 aux have,utilized
R462 T2356 T2357 compound transcriptome,analyses
R463 T2357 T2343 dobj analyses,utilized
R464 T2358 T2359 aux to,identify
R465 T2359 T2343 advcl identify,utilized
R466 T2360 T2359 dobj genes,identify
R467 T2361 T2362 advmod specifically,expressed
R468 T2362 T2360 acl expressed,genes
R469 T2363 T2362 prep in,expressed
R470 T2364 T2365 compound ES,cells
R471 T2365 T2363 pobj cells,in
R472 T2366 T2365 cc and,cells
R473 T2367 T2368 amod early,embryos
R474 T2368 T2365 conj embryos,cells
R475 T2369 T2343 punct .,utilized
R476 T2371 T2372 det These,analyses
R477 T2372 T2373 nsubj analyses,identified
R478 T2374 T2372 punct ", ",analyses
R479 T2375 T2372 prep including,analyses
R480 T2376 T2377 compound DNA,analyses
R481 T2377 T2375 pobj analyses,including
R482 T2378 T2377 compound microarray,analyses
R483 T2379 T2380 punct [,7
R484 T2380 T2377 parataxis 7,analyses
R485 T2381 T2380 punct ],7
R486 T2382 T2377 cc and,analyses
R487 T2383 T2384 amod expressed,sequence
R488 T2384 T2385 compound sequence,analyses
R489 T2385 T2377 conj analyses,analyses
R490 T2386 T2385 compound tag,analyses
R491 T2387 T2388 punct [,8
R492 T2388 T2385 parataxis 8,analyses
R493 T2389 T2390 punct -,12
R494 T2390 T2388 prep 12,8
R495 T2391 T2388 punct ],8
R496 T2392 T2373 punct ", ",identified
R497 T2393 T2394 amod several,transcripts
R498 T2394 T2373 dobj transcripts,identified
R499 T2395 T2394 amod common,transcripts
R500 T2396 T2394 punct ", ",transcripts
R501 T2397 T2394 prep including,transcripts
R502 T2398 T2397 pobj ESG1,including
R503 T2399 T2400 dep that,designated
R504 T2400 T2394 relcl designated,transcripts
R505 T2401 T2400 auxpass was,designated
R506 T2402 T2400 advmod also,designated
R507 T2403 T2400 oprd dppa5,designated
R508 T2404 T2403 cc or,dppa5
R509 T2405 T2403 conj ECAT2,dppa5
R510 T2406 T2373 punct .,identified
R511 T2408 T2409 nsubjpass ESG1,identified
R512 T2410 T2409 auxpass was,identified
R513 T2411 T2409 advmod originally,identified
R514 T2412 T2409 prep as,identified
R515 T2413 T2414 det a,Ph34
R516 T2414 T2412 pobj Ph34,as
R517 T2415 T2414 compound transcript,Ph34
R518 T2416 T2417 dep that,regulated
R519 T2417 T2414 relcl regulated,Ph34
R520 T2418 T2417 auxpass was,regulated
R521 T2419 T2417 advmod down,regulated
R522 T2420 T2417 punct -,regulated
R523 T2421 T2417 agent by,regulated
R524 T2422 T2423 amod retinoic,acid
R525 T2423 T2421 pobj acid,by
R526 T2424 T2417 prep in,regulated
R527 T2425 T2426 amod embryonic,carcinoma
R528 T2426 T2427 compound carcinoma,cells
R529 T2427 T2424 pobj cells,in
R530 T2428 T2429 punct [,13
R531 T2429 T2417 parataxis 13,regulated
R532 T2430 T2429 punct ],13
R533 T2431 T2409 punct .,identified
R534 T2433 T2434 det The,expression
R535 T2434 T2435 nsubjpass expression,confined
R536 T2436 T2434 prep of,expression
R537 T2437 T2438 det this,gene
R538 T2438 T2436 pobj gene,of
R539 T2439 T2435 auxpass was,confined
R540 T2440 T2435 prep in,confined
R541 T2441 T2440 pobj mice,in
R542 T2442 T2435 prep to,confined
R543 T2443 T2444 amod early,embryos
R544 T2444 T2442 pobj embryos,to
R545 T2445 T2444 cc and,embryos
R546 T2446 T2447 compound germ,cells
R547 T2447 T2444 conj cells,embryos
R548 T2448 T2449 punct [,14
R549 T2449 T2435 parataxis 14,confined
R550 T2450 T2449 punct ],14
R551 T2451 T2435 punct .,confined
R552 T2453 T2454 nsubjpass It,expressed
R553 T2455 T2454 auxpass is,expressed
R554 T2456 T2454 advmod also,expressed
R555 T2457 T2454 prep in,expressed
R556 T2458 T2459 amod pluripotent,cells
R557 T2459 T2457 pobj cells,in
R558 T2460 T2459 punct ", ",cells
R559 T2461 T2459 prep including,cells
R560 T2462 T2463 compound ES,cells
R561 T2463 T2461 pobj cells,including
R562 T2464 T2463 punct ", ",cells
R563 T2465 T2466 amod embryonic,cells
R564 T2466 T2463 conj cells,cells
R565 T2467 T2466 compound germ,cells
R566 T2468 T2466 punct ", ",cells
R567 T2469 T2466 cc and,cells
R568 T2470 T2471 amod multipotent,cells
R569 T2471 T2466 conj cells,cells
R570 T2472 T2471 compound germline,cells
R571 T2473 T2471 compound stem,cells
R572 T2474 T2475 punct [,15
R573 T2475 T2454 parataxis 15,expressed
R574 T2476 T2475 punct ],15
R575 T2477 T2454 punct .,expressed
R576 T2479 T2480 nsubj ESG1,encodes
R577 T2481 T2482 det a,polypeptide
R578 T2482 T2480 dobj polypeptide,encodes
R579 T2483 T2482 prep of,polypeptide
R580 T2484 T2485 nummod 118,acids
R581 T2485 T2483 pobj acids,of
R582 T2486 T2485 compound amino,acids
R583 T2487 T2488 dep that,contains
R584 T2488 T2482 relcl contains,polypeptide
R585 T2489 T2490 det a,domain
R586 T2490 T2488 dobj domain,contains
R587 T2491 T2490 amod single,domain
R588 T2492 T2490 compound KH,domain
R589 T2493 T2490 punct ", ",domain
R590 T2494 T2495 dep which,is
R591 T2495 T2490 relcl is,domain
R592 T2496 T2497 det an,domain
R593 T2497 T2495 attr domain,is
R594 T2498 T2499 npadvmod RNA,binding
R595 T2499 T2497 amod binding,domain
R596 T2500 T2499 punct -,binding
R597 T2501 T2502 punct [,16
R598 T2502 T2495 parataxis 16,is
R599 T2503 T2502 punct ],16
R600 T2504 T2480 punct .,encodes
R601 T2506 T2507 nsubj It,remains
R602 T2508 T2507 acomp unclear,remains
R603 T2509 T2507 punct ", ",remains
R604 T2510 T2507 advmod however,remains
R605 T2511 T2507 punct ", ",remains
R606 T2512 T2513 mark if,functions
R607 T2513 T2507 ccomp functions,remains
R608 T2514 T2513 nsubj ESG1,functions
R609 T2515 T2513 prep as,functions
R610 T2516 T2517 det an,protein
R611 T2517 T2515 pobj protein,as
R612 T2518 T2519 npadvmod RNA,binding
R613 T2519 T2517 amod binding,protein
R614 T2520 T2519 punct -,binding
R615 T2521 T2513 cc or,functions
R616 T2522 T2523 det the,roles
R617 T2523 T2513 conj roles,functions
R618 T2524 T2525 nsubj it,plays
R619 T2525 T2523 advcl plays,roles
R620 T2526 T2525 prep in,plays
R621 T2527 T2528 compound ES,cells
R622 T2528 T2526 pobj cells,in
R623 T2529 T2528 cc and,cells
R624 T2530 T2528 conj mice,cells
R625 T2531 T2507 punct .,remains
R626 T2533 T2534 amod Previous,screening
R627 T2535 T2536 amod genomic,library
R628 T2536 T2534 compound library,screening
R629 T2537 T2534 prep by,screening
R630 T2538 T2539 amod identified,clones
R631 T2539 T2537 pobj clones,by
R632 T2540 T2539 amod genomic,clones
R633 T2541 T2539 acl containing,clones
R634 T2542 T2543 det the,gene
R635 T2543 T2541 dobj gene,containing
R636 T2544 T2543 compound mouse,gene
R637 T2545 T2543 compound ESG1,gene
R638 T2546 T2543 cc and,gene
R639 T2547 T2548 nummod seven,pseudogenes
R640 T2548 T2543 conj pseudogenes,gene
R641 T2549 T2550 punct [,17
R642 T2550 T2541 parataxis 17,containing
R643 T2551 T2550 punct ],17
R644 T2552 T2534 punct .,screening
R645 T2554 T2555 nsubj Two,exhibit
R646 T2556 T2554 prep of,Two
R647 T2557 T2558 det these,pseudogenes
R648 T2558 T2556 pobj pseudogenes,of
R649 T2559 T2560 det a,structure
R650 T2560 T2555 dobj structure,exhibit
R651 T2561 T2560 amod similar,structure
R652 T2562 T2563 compound exon,intron
R653 T2563 T2560 compound intron,structure
R654 T2564 T2563 punct -,intron
R655 T2565 T2560 prep as,structure
R656 T2566 T2567 det the,gene
R657 T2567 T2565 pobj gene,as
R658 T2568 T2567 compound ESG1,gene
R659 T2569 T2555 punct ", ",exhibit
R660 T2570 T2555 advcl indicating,exhibit
R661 T2571 T2572 poss their,generation
R662 T2572 T2570 dobj generation,indicating
R663 T2573 T2570 prep by,indicating
R664 T2574 T2575 compound gene,duplication
R665 T2575 T2573 pobj duplication,by
R666 T2576 T2555 punct .,exhibit
R667 T2578 T2579 det The,pseudogenes
R668 T2579 T2582 nsubj pseudogenes,contain
R669 T2580 T2579 nummod five,pseudogenes
R670 T2581 T2579 amod remaining,pseudogenes
R671 T2583 T2582 aux did,contain
R672 T2584 T2582 neg not,contain
R673 T2585 T2586 det any,introns
R674 T2586 T2582 dobj introns,contain
R675 T2587 T2582 punct ", ",contain
R676 T2588 T2582 advcl indicating,contain
R677 T2589 T2590 mark that,generated
R678 T2590 T2588 ccomp generated,indicating
R679 T2591 T2590 nsubjpass these,generated
R680 T2592 T2590 auxpass were,generated
R681 T2593 T2590 agent by,generated
R682 T2594 T2593 pobj retrotransposition,by
R683 T2595 T2594 prep of,retrotransposition
R684 T2596 T2597 compound ESG1,transcripts
R685 T2597 T2595 pobj transcripts,of
R686 T2598 T2582 punct .,contain
R687 T2600 T2601 det The,localizations
R688 T2601 T2603 nsubjpass localizations,reported
R689 T2602 T2601 amod chromosomal,localizations
R690 T2604 T2601 prep of,localizations
R691 T2605 T2606 det the,gene
R692 T2606 T2604 pobj gene,of
R693 T2607 T2606 compound mouse,gene
R694 T2608 T2606 compound ESG1,gene
R695 T2609 T2606 cc and,gene
R696 T2610 T2606 conj pseudogenes,gene
R697 T2611 T2603 punct ", ",reported
R698 T2612 T2603 advmod however,reported
R699 T2613 T2603 punct ", ",reported
R700 T2614 T2603 aux have,reported
R701 T2615 T2603 neg not,reported
R702 T2616 T2603 auxpass been,reported
R703 T2617 T2603 punct .,reported
R704 T2619 T2620 prep In,determined
R705 T2621 T2622 det this,study
R706 T2622 T2619 pobj study,In
R707 T2623 T2620 punct ", ",determined
R708 T2624 T2620 nsubj we,determined
R709 T2625 T2626 det the,structure
R710 T2626 T2620 dobj structure,determined
R711 T2627 T2626 prep of,structure
R712 T2628 T2629 det the,gene
R713 T2629 T2627 pobj gene,of
R714 T2630 T2629 compound mouse,gene
R715 T2631 T2629 acl encoding,gene
R716 T2632 T2633 det this,protein
R717 T2633 T2631 dobj protein,encoding
R718 T2634 T2633 cc and,protein
R719 T2635 T2636 amod related,pseudogenes
R720 T2636 T2633 conj pseudogenes,protein
R721 T2637 T2620 punct .,determined
R722 T2639 T2640 nsubj We,performed
R723 T2641 T2640 advmod also,performed
R724 T2642 T2643 compound gene,targeting
R725 T2643 T2640 dobj targeting,performed
R726 T2644 T2645 aux to,determine
R727 T2645 T2640 advcl determine,performed
R728 T2646 T2647 det the,function
R729 T2647 T2645 dobj function,determine
R730 T2648 T2647 amod physiological,function
R731 T2649 T2647 prep of,function
R732 T2650 T2649 pobj ESG1,of
R733 T2651 T2640 punct .,performed