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PMC:138691 / 7499-8663 JSONTXT 4 Projects

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Id Subject Object Predicate Lexical cue
T2154 0-3 DT denotes The
T2156 4-10 JJ denotes second
T2155 11-16 NN denotes paper
T2158 17-26 VBG denotes providing
T2159 27-35 NN denotes evidence
T2160 35-37 , denotes ,
T2161 37-39 IN denotes by
T2162 40-46 NNP denotes Davies
T2163 47-49 FW denotes et
T2164 50-52 FW denotes al
T2165 53-54 -LRB- denotes [
T2166 54-56 CD denotes 26
T2167 56-57 -RRB- denotes ]
T2168 57-59 , denotes ,
T2157 59-61 VBZ denotes is
T2169 62-63 DT denotes a
T2171 64-75 JJ denotes biochemical
T2170 76-81 NN denotes study
T2172 82-84 IN denotes of
T2173 85-88 DT denotes the
T2174 89-100 NN denotes interaction
T2175 101-108 IN denotes between
T2176 109-112 DT denotes the
T2178 113-123 JJ denotes homologous
T2179 124-135 NN denotes recombinase
T2177 136-141 NN denotes RAD51
T2180 142-145 CC denotes and
T2181 146-147 DT denotes a
T2182 148-155 NN denotes peptide
T2183 156-166 VBG denotes consisting
T2184 167-169 IN denotes of
T2185 170-173 CD denotes one
T2186 174-176 IN denotes of
T2187 177-180 DT denotes the
T2189 181-186 CD denotes eight
T2190 187-190 NN denotes BRC
T2188 191-198 NNS denotes repeats
T2191 199-203 IN denotes from
T2192 204-209 JJ denotes human
T2193 210-215 NN denotes BRCA2
T2194 215-216 . denotes .
T2195 216-343 sentence denotes Expression of a single BRC repeat (BRC4) had previously been reported to act as an inhibitor of DNA repair by Chen et al [27].
T2196 217-227 NN denotes Expression
T2198 228-230 IN denotes of
T2199 231-232 DT denotes a
T2201 233-239 JJ denotes single
T2202 240-243 NN denotes BRC
T2200 244-250 NN denotes repeat
T2203 251-252 -LRB- denotes (
T2204 252-256 NN denotes BRC4
T2205 256-257 -RRB- denotes )
T2206 258-261 VBD denotes had
T2207 262-272 RB denotes previously
T2208 273-277 VBN denotes been
T2197 278-286 VBN denotes reported
T2209 287-289 TO denotes to
T2210 290-293 VB denotes act
T2211 294-296 IN denotes as
T2212 297-299 DT denotes an
T2213 300-309 NN denotes inhibitor
T2214 310-312 IN denotes of
T2215 313-316 NN denotes DNA
T2216 317-323 NN denotes repair
T2217 324-326 IN denotes by
T2218 327-331 NNP denotes Chen
T2219 332-334 FW denotes et
T2220 335-337 FW denotes al
T2221 338-339 -LRB- denotes [
T2222 339-341 CD denotes 27
T2223 341-342 -RRB- denotes ]
T2224 342-343 . denotes .
T2225 343-611 sentence denotes These investigators showed that expression of constructs containing the BRC4 repeat in MCF-7 cells enhances the radiosensitivity of cells and blocks both the G2/M delay associated with damage and the ability of the transfected cells to assembly subnuclear RAD51 foci.
T2226 344-349 DT denotes These
T2227 350-363 NNS denotes investigators
T2228 364-370 VBD denotes showed
T2229 371-375 IN denotes that
T2231 376-386 NN denotes expression
T2232 387-389 IN denotes of
T2233 390-400 NNS denotes constructs
T2234 401-411 VBG denotes containing
T2235 412-415 DT denotes the
T2237 416-420 NN denotes BRC4
T2236 421-427 NN denotes repeat
T2238 428-430 IN denotes in
T2239 431-434 NN denotes MCF
T2241 434-435 HYPH denotes -
T2242 435-436 CD denotes 7
T2240 437-442 NNS denotes cells
T2230 443-451 VBZ denotes enhances
T2243 452-455 DT denotes the
T2244 456-472 NN denotes radiosensitivity
T2245 473-475 IN denotes of
T2246 476-481 NNS denotes cells
T2247 482-485 CC denotes and
T2248 486-492 VBZ denotes blocks
T2249 493-497 CC denotes both
T2251 498-501 DT denotes the
T2252 502-504 NN denotes G2
T2254 504-505 HYPH denotes /
T2253 505-506 NN denotes M
T2250 507-512 NN denotes delay
T2255 513-523 VBN denotes associated
T2256 524-528 IN denotes with
T2257 529-535 NN denotes damage
T2258 536-539 CC denotes and
T2259 540-543 DT denotes the
T2260 544-551 NN denotes ability
T2261 552-554 IN denotes of
T2262 555-558 DT denotes the
T2264 559-570 VBN denotes transfected
T2263 571-576 NNS denotes cells
T2265 577-579 TO denotes to
T2266 580-588 VB denotes assembly
T2267 589-599 JJ denotes subnuclear
T2269 600-605 NN denotes RAD51
T2268 606-610 NNS denotes foci
T2270 610-611 . denotes .
T2271 611-772 sentence denotes In the paper by Davies et al, data provide evidence for a plausible mechanism of the dominant negative effect associated with expression of a single BRC repeat.
T2272 612-614 IN denotes In
T2274 615-618 DT denotes the
T2275 619-624 NN denotes paper
T2276 625-627 IN denotes by
T2277 628-634 NNP denotes Davies
T2278 635-637 FW denotes et
T2279 638-640 FW denotes al
T2280 640-642 , denotes ,
T2281 642-646 NNS denotes data
T2273 647-654 VBP denotes provide
T2282 655-663 NN denotes evidence
T2283 664-667 IN denotes for
T2284 668-669 DT denotes a
T2286 670-679 JJ denotes plausible
T2285 680-689 NN denotes mechanism
T2287 690-692 IN denotes of
T2288 693-696 DT denotes the
T2290 697-705 JJ denotes dominant
T2291 706-714 JJ denotes negative
T2289 715-721 NN denotes effect
T2292 722-732 VBN denotes associated
T2293 733-737 IN denotes with
T2294 738-748 NN denotes expression
T2295 749-751 IN denotes of
T2296 752-753 DT denotes a
T2298 754-760 JJ denotes single
T2299 761-764 NN denotes BRC
T2297 765-771 NN denotes repeat
T2300 771-772 . denotes .
T2301 772-944 sentence denotes DNA binding assays and electron microscopy methods were used to show that a BRC3 peptide interferes with the ability of RAD51 to assemble into oligomeric filaments on DNA.
T2302 773-776 NN denotes DNA
T2304 777-784 NN denotes binding
T2303 785-791 NNS denotes assays
T2306 792-795 CC denotes and
T2307 796-804 NN denotes electron
T2308 805-815 NN denotes microscopy
T2309 816-823 NNS denotes methods
T2310 824-828 VBD denotes were
T2305 829-833 VBN denotes used
T2311 834-836 TO denotes to
T2312 837-841 VB denotes show
T2313 842-846 IN denotes that
T2315 847-848 DT denotes a
T2317 849-853 NN denotes BRC3
T2316 854-861 NN denotes peptide
T2314 862-872 VBZ denotes interferes
T2318 873-877 IN denotes with
T2319 878-881 DT denotes the
T2320 882-889 NN denotes ability
T2321 890-892 IN denotes of
T2322 893-898 NN denotes RAD51
T2323 899-901 TO denotes to
T2324 902-910 VB denotes assemble
T2325 911-915 IN denotes into
T2326 916-926 JJ denotes oligomeric
T2327 927-936 NNS denotes filaments
T2328 937-939 IN denotes on
T2329 940-943 NN denotes DNA
T2330 943-944 . denotes .
T2331 944-1015 sentence denotes A BRC4 peptide was also reported to inhibit the RAD51–DNA interaction.
T2332 945-946 DT denotes A
T2334 947-951 NN denotes BRC4
T2333 952-959 NN denotes peptide
T2336 960-963 VBD denotes was
T2337 964-968 RB denotes also
T2335 969-977 VBN denotes reported
T2338 978-980 TO denotes to
T2339 981-988 VB denotes inhibit
T2340 989-992 DT denotes the
T2342 993-998 NN denotes RAD51
T2344 998-999 HYPH denotes –
T2343 999-1002 NN denotes DNA
T2341 1003-1014 NN denotes interaction
T2345 1014-1015 . denotes .
T2346 1015-1164 sentence denotes These experiments raise the possibility that the full-length BRCA2 protein could act as a negative regulator of inappropriate RAD51–DNA interaction.
T2347 1016-1021 DT denotes These
T2348 1022-1033 NNS denotes experiments
T2349 1034-1039 VBP denotes raise
T2350 1040-1043 DT denotes the
T2351 1044-1055 NN denotes possibility
T2352 1056-1060 IN denotes that
T2354 1061-1064 DT denotes the
T2356 1065-1069 JJ denotes full
T2358 1069-1070 HYPH denotes -
T2357 1070-1076 NN denotes length
T2359 1077-1082 NN denotes BRCA2
T2355 1083-1090 NN denotes protein
T2360 1091-1096 MD denotes could
T2353 1097-1100 VB denotes act
T2361 1101-1103 IN denotes as
T2362 1104-1105 DT denotes a
T2364 1106-1114 JJ denotes negative
T2363 1115-1124 NN denotes regulator
T2365 1125-1127 IN denotes of
T2366 1128-1141 JJ denotes inappropriate
T2368 1142-1147 NN denotes RAD51
T2370 1147-1148 HYPH denotes –
T2369 1148-1151 NN denotes DNA
T2367 1152-1163 NN denotes interaction
T2371 1163-1164 . denotes .
R1262 T2154 T2155 det The,paper
R1263 T2155 T2157 nsubj paper,is
R1264 T2156 T2155 amod second,paper
R1265 T2158 T2155 acl providing,paper
R1266 T2159 T2158 dobj evidence,providing
R1267 T2160 T2155 punct ", ",paper
R1268 T2161 T2155 prep by,paper
R1269 T2162 T2161 pobj Davies,by
R1270 T2163 T2164 advmod et,al
R1271 T2164 T2162 advmod al,Davies
R1272 T2165 T2166 punct [,26
R1273 T2166 T2155 parataxis 26,paper
R1274 T2167 T2166 punct ],26
R1275 T2168 T2157 punct ", ",is
R1276 T2169 T2170 det a,study
R1277 T2170 T2157 attr study,is
R1278 T2171 T2170 amod biochemical,study
R1279 T2172 T2170 prep of,study
R1280 T2173 T2174 det the,interaction
R1281 T2174 T2172 pobj interaction,of
R1282 T2175 T2174 prep between,interaction
R1283 T2176 T2177 det the,RAD51
R1284 T2177 T2175 pobj RAD51,between
R1285 T2178 T2177 amod homologous,RAD51
R1286 T2179 T2177 compound recombinase,RAD51
R1287 T2180 T2177 cc and,RAD51
R1288 T2181 T2182 det a,peptide
R1289 T2182 T2177 conj peptide,RAD51
R1290 T2183 T2182 acl consisting,peptide
R1291 T2184 T2183 prep of,consisting
R1292 T2185 T2184 pobj one,of
R1293 T2186 T2185 prep of,one
R1294 T2187 T2188 det the,repeats
R1295 T2188 T2186 pobj repeats,of
R1296 T2189 T2188 nummod eight,repeats
R1297 T2190 T2188 compound BRC,repeats
R1298 T2191 T2188 prep from,repeats
R1299 T2192 T2193 amod human,BRCA2
R1300 T2193 T2191 pobj BRCA2,from
R1301 T2194 T2157 punct .,is
R1302 T2196 T2197 nsubjpass Expression,reported
R1303 T2198 T2196 prep of,Expression
R1304 T2199 T2200 det a,repeat
R1305 T2200 T2198 pobj repeat,of
R1306 T2201 T2200 amod single,repeat
R1307 T2202 T2200 compound BRC,repeat
R1308 T2203 T2200 punct (,repeat
R1309 T2204 T2200 appos BRC4,repeat
R1310 T2205 T2197 punct ),reported
R1311 T2206 T2197 aux had,reported
R1312 T2207 T2197 advmod previously,reported
R1313 T2208 T2197 auxpass been,reported
R1314 T2209 T2210 aux to,act
R1315 T2210 T2197 xcomp act,reported
R1316 T2211 T2210 prep as,act
R1317 T2212 T2213 det an,inhibitor
R1318 T2213 T2211 pobj inhibitor,as
R1319 T2214 T2213 prep of,inhibitor
R1320 T2215 T2216 compound DNA,repair
R1321 T2216 T2214 pobj repair,of
R1322 T2217 T2197 agent by,reported
R1323 T2218 T2217 pobj Chen,by
R1324 T2219 T2220 advmod et,al
R1325 T2220 T2218 advmod al,Chen
R1326 T2221 T2222 punct [,27
R1327 T2222 T2197 parataxis 27,reported
R1328 T2223 T2222 punct ],27
R1329 T2224 T2197 punct .,reported
R1330 T2226 T2227 det These,investigators
R1331 T2227 T2228 nsubj investigators,showed
R1332 T2229 T2230 mark that,enhances
R1333 T2230 T2228 ccomp enhances,showed
R1334 T2231 T2230 nsubj expression,enhances
R1335 T2232 T2231 prep of,expression
R1336 T2233 T2232 pobj constructs,of
R1337 T2234 T2233 acl containing,constructs
R1338 T2235 T2236 det the,repeat
R1339 T2236 T2234 dobj repeat,containing
R1340 T2237 T2236 compound BRC4,repeat
R1341 T2238 T2236 prep in,repeat
R1342 T2239 T2240 nmod MCF,cells
R1343 T2240 T2238 pobj cells,in
R1344 T2241 T2239 punct -,MCF
R1345 T2242 T2239 nummod 7,MCF
R1346 T2243 T2244 det the,radiosensitivity
R1347 T2244 T2230 dobj radiosensitivity,enhances
R1348 T2245 T2244 prep of,radiosensitivity
R1349 T2246 T2245 pobj cells,of
R1350 T2247 T2230 cc and,enhances
R1351 T2248 T2230 conj blocks,enhances
R1352 T2249 T2250 preconj both,delay
R1353 T2250 T2248 dobj delay,blocks
R1354 T2251 T2250 det the,delay
R1355 T2252 T2253 compound G2,M
R1356 T2253 T2250 compound M,delay
R1357 T2254 T2253 punct /,M
R1358 T2255 T2250 acl associated,delay
R1359 T2256 T2255 prep with,associated
R1360 T2257 T2256 pobj damage,with
R1361 T2258 T2250 cc and,delay
R1362 T2259 T2260 det the,ability
R1363 T2260 T2250 conj ability,delay
R1364 T2261 T2260 prep of,ability
R1365 T2262 T2263 det the,cells
R1366 T2263 T2261 pobj cells,of
R1367 T2264 T2263 amod transfected,cells
R1368 T2265 T2266 aux to,assembly
R1369 T2266 T2260 acl assembly,ability
R1370 T2267 T2268 amod subnuclear,foci
R1371 T2268 T2266 dobj foci,assembly
R1372 T2269 T2268 compound RAD51,foci
R1373 T2270 T2228 punct .,showed
R1374 T2272 T2273 prep In,provide
R1375 T2274 T2275 det the,paper
R1376 T2275 T2272 pobj paper,In
R1377 T2276 T2275 prep by,paper
R1378 T2277 T2276 pobj Davies,by
R1379 T2278 T2279 advmod et,al
R1380 T2279 T2277 advmod al,Davies
R1381 T2280 T2273 punct ", ",provide
R1382 T2281 T2273 nsubj data,provide
R1383 T2282 T2273 dobj evidence,provide
R1384 T2283 T2282 prep for,evidence
R1385 T2284 T2285 det a,mechanism
R1386 T2285 T2283 pobj mechanism,for
R1387 T2286 T2285 amod plausible,mechanism
R1388 T2287 T2285 prep of,mechanism
R1389 T2288 T2289 det the,effect
R1390 T2289 T2287 pobj effect,of
R1391 T2290 T2289 amod dominant,effect
R1392 T2291 T2289 amod negative,effect
R1393 T2292 T2289 acl associated,effect
R1394 T2293 T2292 prep with,associated
R1395 T2294 T2293 pobj expression,with
R1396 T2295 T2294 prep of,expression
R1397 T2296 T2297 det a,repeat
R1398 T2297 T2295 pobj repeat,of
R1399 T2298 T2297 amod single,repeat
R1400 T2299 T2297 compound BRC,repeat
R1401 T2300 T2273 punct .,provide
R1402 T2302 T2303 compound DNA,assays
R1403 T2303 T2305 nsubjpass assays,used
R1404 T2304 T2303 compound binding,assays
R1405 T2306 T2303 cc and,assays
R1406 T2307 T2308 compound electron,microscopy
R1407 T2308 T2309 compound microscopy,methods
R1408 T2309 T2303 conj methods,assays
R1409 T2310 T2305 auxpass were,used
R1410 T2311 T2312 aux to,show
R1411 T2312 T2305 advcl show,used
R1412 T2313 T2314 mark that,interferes
R1413 T2314 T2312 ccomp interferes,show
R1414 T2315 T2316 det a,peptide
R1415 T2316 T2314 nsubj peptide,interferes
R1416 T2317 T2316 compound BRC3,peptide
R1417 T2318 T2314 prep with,interferes
R1418 T2319 T2320 det the,ability
R1419 T2320 T2318 pobj ability,with
R1420 T2321 T2320 prep of,ability
R1421 T2322 T2321 pobj RAD51,of
R1422 T2323 T2324 aux to,assemble
R1423 T2324 T2320 acl assemble,ability
R1424 T2325 T2324 prep into,assemble
R1425 T2326 T2327 amod oligomeric,filaments
R1426 T2327 T2325 pobj filaments,into
R1427 T2328 T2324 prep on,assemble
R1428 T2329 T2328 pobj DNA,on
R1429 T2330 T2305 punct .,used
R1430 T2332 T2333 det A,peptide
R1431 T2333 T2335 nsubjpass peptide,reported
R1432 T2334 T2333 compound BRC4,peptide
R1433 T2336 T2335 auxpass was,reported
R1434 T2337 T2335 advmod also,reported
R1435 T2338 T2339 aux to,inhibit
R1436 T2339 T2335 xcomp inhibit,reported
R1437 T2340 T2341 det the,interaction
R1438 T2341 T2339 dobj interaction,inhibit
R1439 T2342 T2343 compound RAD51,DNA
R1440 T2343 T2341 compound DNA,interaction
R1441 T2344 T2343 punct –,DNA
R1442 T2345 T2335 punct .,reported
R1443 T2347 T2348 det These,experiments
R1444 T2348 T2349 nsubj experiments,raise
R1445 T2350 T2351 det the,possibility
R1446 T2351 T2349 dobj possibility,raise
R1447 T2352 T2353 mark that,act
R1448 T2353 T2351 acl act,possibility
R1449 T2354 T2355 det the,protein
R1450 T2355 T2353 nsubj protein,act
R1451 T2356 T2357 amod full,length
R1452 T2357 T2355 compound length,protein
R1453 T2358 T2357 punct -,length
R1454 T2359 T2355 compound BRCA2,protein
R1455 T2360 T2353 aux could,act
R1456 T2361 T2353 prep as,act
R1457 T2362 T2363 det a,regulator
R1458 T2363 T2361 pobj regulator,as
R1459 T2364 T2363 amod negative,regulator
R1460 T2365 T2363 prep of,regulator
R1461 T2366 T2367 amod inappropriate,interaction
R1462 T2367 T2365 pobj interaction,of
R1463 T2368 T2369 compound RAD51,DNA
R1464 T2369 T2367 compound DNA,interaction
R1465 T2370 T2369 punct –,DNA
R1466 T2371 T2349 punct .,raise