Id |
Subject |
Object |
Predicate |
Lexical cue |
T1386 |
0-5 |
IN |
denotes |
While |
T1388 |
6-14 |
NNP |
denotes |
Moynahan |
T1389 |
15-17 |
FW |
denotes |
et |
T1390 |
18-20 |
FW |
denotes |
al |
T1387 |
21-25 |
VBD |
denotes |
were |
T1392 |
26-33 |
JJ |
denotes |
careful |
T1393 |
34-36 |
TO |
denotes |
to |
T1394 |
37-42 |
VB |
denotes |
point |
T1395 |
43-46 |
RP |
denotes |
out |
T1396 |
47-51 |
DT |
denotes |
this |
T1397 |
52-59 |
NN |
denotes |
problem |
T1398 |
59-61 |
, |
denotes |
, |
T1399 |
61-64 |
CD |
denotes |
two |
T1400 |
65-69 |
NNS |
denotes |
sets |
T1401 |
70-72 |
IN |
denotes |
of |
T1402 |
73-80 |
NNS |
denotes |
results |
T1391 |
81-86 |
VBP |
denotes |
argue |
T1403 |
87-94 |
IN |
denotes |
against |
T1404 |
95-98 |
DT |
denotes |
the |
T1405 |
99-110 |
NN |
denotes |
possibility |
T1406 |
111-115 |
IN |
denotes |
that |
T1408 |
116-119 |
DT |
denotes |
the |
T1410 |
120-135 |
JJ |
denotes |
recombinational |
T1411 |
136-142 |
NN |
denotes |
repair |
T1409 |
143-153 |
NN |
denotes |
deficiency |
T1412 |
154-156 |
IN |
denotes |
of |
T1413 |
157-162 |
NN |
denotes |
CAPAN |
T1415 |
162-163 |
HYPH |
denotes |
- |
T1416 |
163-164 |
CD |
denotes |
1 |
T1414 |
165-170 |
NNS |
denotes |
cells |
T1407 |
171-173 |
VBZ |
denotes |
is |
T1417 |
174-184 |
RB |
denotes |
completely |
T1418 |
185-196 |
JJ |
denotes |
independent |
T1419 |
197-199 |
IN |
denotes |
of |
T1420 |
200-203 |
PRP$ |
denotes |
its |
T1421 |
204-210 |
NN |
denotes |
defect |
T1422 |
211-213 |
IN |
denotes |
in |
T1423 |
214-219 |
NN |
denotes |
BRCA2 |
T1424 |
219-220 |
. |
denotes |
. |
T1425 |
220-347 |
sentence |
denotes |
First, in the same study [24], recombination in a mouse ES cell line that expresses only truncated BRCA2 protein was measured. |
T1426 |
221-226 |
RB |
denotes |
First |
T1428 |
226-228 |
, |
denotes |
, |
T1429 |
228-230 |
IN |
denotes |
in |
T1430 |
231-234 |
DT |
denotes |
the |
T1432 |
235-239 |
JJ |
denotes |
same |
T1431 |
240-245 |
NN |
denotes |
study |
T1433 |
246-247 |
-LRB- |
denotes |
[ |
T1434 |
247-249 |
CD |
denotes |
24 |
T1435 |
249-250 |
-RRB- |
denotes |
] |
T1436 |
250-252 |
, |
denotes |
, |
T1437 |
252-265 |
NN |
denotes |
recombination |
T1438 |
266-268 |
IN |
denotes |
in |
T1439 |
269-270 |
DT |
denotes |
a |
T1441 |
271-276 |
NN |
denotes |
mouse |
T1442 |
277-279 |
NN |
denotes |
ES |
T1443 |
280-284 |
NN |
denotes |
cell |
T1440 |
285-289 |
NN |
denotes |
line |
T1444 |
290-294 |
WDT |
denotes |
that |
T1445 |
295-304 |
VBZ |
denotes |
expresses |
T1446 |
305-309 |
RB |
denotes |
only |
T1448 |
310-319 |
VBN |
denotes |
truncated |
T1449 |
320-325 |
NN |
denotes |
BRCA2 |
T1447 |
326-333 |
NN |
denotes |
protein |
T1450 |
334-337 |
VBD |
denotes |
was |
T1427 |
338-346 |
VBN |
denotes |
measured |
T1451 |
346-347 |
. |
denotes |
. |
T1452 |
347-508 |
sentence |
denotes |
This line was found to have lower recombination efficiency than isogenic cells expressing full-length BRCA2 (the defect observed was about fivefold to sixfold). |
T1453 |
348-352 |
DT |
denotes |
This |
T1454 |
353-357 |
NN |
denotes |
line |
T1456 |
358-361 |
VBD |
denotes |
was |
T1455 |
362-367 |
VBN |
denotes |
found |
T1457 |
368-370 |
TO |
denotes |
to |
T1458 |
371-375 |
VB |
denotes |
have |
T1459 |
376-381 |
JJR |
denotes |
lower |
T1461 |
382-395 |
NN |
denotes |
recombination |
T1460 |
396-406 |
NN |
denotes |
efficiency |
T1462 |
407-411 |
IN |
denotes |
than |
T1463 |
412-420 |
JJ |
denotes |
isogenic |
T1464 |
421-426 |
NNS |
denotes |
cells |
T1465 |
427-437 |
VBG |
denotes |
expressing |
T1466 |
438-442 |
JJ |
denotes |
full |
T1468 |
442-443 |
HYPH |
denotes |
- |
T1467 |
443-449 |
NN |
denotes |
length |
T1469 |
450-455 |
NN |
denotes |
BRCA2 |
T1470 |
456-457 |
-LRB- |
denotes |
( |
T1472 |
457-460 |
DT |
denotes |
the |
T1473 |
461-467 |
NN |
denotes |
defect |
T1474 |
468-476 |
VBN |
denotes |
observed |
T1471 |
477-480 |
VBD |
denotes |
was |
T1475 |
481-486 |
RB |
denotes |
about |
T1477 |
487-495 |
RB |
denotes |
fivefold |
T1478 |
496-498 |
IN |
denotes |
to |
T1476 |
499-506 |
RB |
denotes |
sixfold |
T1479 |
506-507 |
-RRB- |
denotes |
) |
T1480 |
507-508 |
. |
denotes |
. |
T1481 |
508-707 |
sentence |
denotes |
Second, in an independent study, Powell was able to compare derivatives of CAPAN-1 that differed only in their ability to express full-length BRCA2 protein (S. Powell, personal communication, 2001). |
T1482 |
509-515 |
RB |
denotes |
Second |
T1484 |
515-517 |
, |
denotes |
, |
T1485 |
517-519 |
IN |
denotes |
in |
T1486 |
520-522 |
DT |
denotes |
an |
T1488 |
523-534 |
JJ |
denotes |
independent |
T1487 |
535-540 |
NN |
denotes |
study |
T1489 |
540-542 |
, |
denotes |
, |
T1490 |
542-548 |
NNP |
denotes |
Powell |
T1483 |
549-552 |
VBD |
denotes |
was |
T1491 |
553-557 |
JJ |
denotes |
able |
T1492 |
558-560 |
TO |
denotes |
to |
T1493 |
561-568 |
VB |
denotes |
compare |
T1494 |
569-580 |
NNS |
denotes |
derivatives |
T1495 |
581-583 |
IN |
denotes |
of |
T1496 |
584-589 |
NN |
denotes |
CAPAN |
T1497 |
589-590 |
HYPH |
denotes |
- |
T1498 |
590-591 |
CD |
denotes |
1 |
T1499 |
592-596 |
WDT |
denotes |
that |
T1500 |
597-605 |
VBD |
denotes |
differed |
T1501 |
606-610 |
RB |
denotes |
only |
T1502 |
611-613 |
IN |
denotes |
in |
T1503 |
614-619 |
PRP$ |
denotes |
their |
T1504 |
620-627 |
NN |
denotes |
ability |
T1505 |
628-630 |
TO |
denotes |
to |
T1506 |
631-638 |
VB |
denotes |
express |
T1507 |
639-643 |
JJ |
denotes |
full |
T1509 |
643-644 |
HYPH |
denotes |
- |
T1508 |
644-650 |
NN |
denotes |
length |
T1511 |
651-656 |
NN |
denotes |
BRCA2 |
T1510 |
657-664 |
NN |
denotes |
protein |
T1512 |
665-666 |
-LRB- |
denotes |
( |
T1514 |
666-668 |
NNP |
denotes |
S. |
T1513 |
669-675 |
NNP |
denotes |
Powell |
T1515 |
675-677 |
, |
denotes |
, |
T1516 |
677-685 |
JJ |
denotes |
personal |
T1517 |
686-699 |
NN |
denotes |
communication |
T1518 |
699-701 |
, |
denotes |
, |
T1519 |
701-705 |
CD |
denotes |
2001 |
T1520 |
705-706 |
-RRB- |
denotes |
) |
T1521 |
706-707 |
. |
denotes |
. |
T1522 |
707-896 |
sentence |
denotes |
In these experiments, the derivative expressing full-length BRCA2 yielded 10-fold more recombinants than controls expressing only truncated BRCA2 (S. Powell, personal communication, 2001). |
T1523 |
708-710 |
IN |
denotes |
In |
T1525 |
711-716 |
DT |
denotes |
these |
T1526 |
717-728 |
NNS |
denotes |
experiments |
T1527 |
728-730 |
, |
denotes |
, |
T1528 |
730-733 |
DT |
denotes |
the |
T1529 |
734-744 |
NN |
denotes |
derivative |
T1530 |
745-755 |
VBG |
denotes |
expressing |
T1531 |
756-760 |
JJ |
denotes |
full |
T1533 |
760-761 |
HYPH |
denotes |
- |
T1532 |
761-767 |
NN |
denotes |
length |
T1534 |
768-773 |
NN |
denotes |
BRCA2 |
T1524 |
774-781 |
VBD |
denotes |
yielded |
T1535 |
782-789 |
RB |
denotes |
10-fold |
T1536 |
790-794 |
JJR |
denotes |
more |
T1537 |
795-807 |
NNS |
denotes |
recombinants |
T1538 |
808-812 |
IN |
denotes |
than |
T1539 |
813-821 |
NNS |
denotes |
controls |
T1540 |
822-832 |
VBG |
denotes |
expressing |
T1541 |
833-837 |
RB |
denotes |
only |
T1543 |
838-847 |
VBN |
denotes |
truncated |
T1542 |
848-853 |
NN |
denotes |
BRCA2 |
T1544 |
854-855 |
-LRB- |
denotes |
( |
T1546 |
855-857 |
NNP |
denotes |
S. |
T1545 |
858-864 |
NNP |
denotes |
Powell |
T1547 |
864-866 |
, |
denotes |
, |
T1548 |
866-874 |
JJ |
denotes |
personal |
T1549 |
875-888 |
NN |
denotes |
communication |
T1550 |
888-890 |
, |
denotes |
, |
T1551 |
890-894 |
CD |
denotes |
2001 |
T1552 |
894-895 |
-RRB- |
denotes |
) |
T1553 |
895-896 |
. |
denotes |
. |
T1554 |
896-1192 |
sentence |
denotes |
While the experimental design of these experiments was somewhat different from that of Moyna-han et al [24], the results raise the possibility that CAPAN-1 cells have more than one mutation that lowers the efficiency of recombinational repair relative to that observed in other human cell lines. |
T1555 |
897-902 |
IN |
denotes |
While |
T1557 |
903-906 |
DT |
denotes |
the |
T1559 |
907-919 |
JJ |
denotes |
experimental |
T1558 |
920-926 |
NN |
denotes |
design |
T1560 |
927-929 |
IN |
denotes |
of |
T1561 |
930-935 |
DT |
denotes |
these |
T1562 |
936-947 |
NNS |
denotes |
experiments |
T1556 |
948-951 |
VBD |
denotes |
was |
T1564 |
952-960 |
RB |
denotes |
somewhat |
T1565 |
961-970 |
JJ |
denotes |
different |
T1566 |
971-975 |
IN |
denotes |
from |
T1567 |
976-980 |
DT |
denotes |
that |
T1568 |
981-983 |
IN |
denotes |
of |
T1569 |
984-989 |
NNP |
denotes |
Moyna |
T1571 |
989-990 |
HYPH |
denotes |
- |
T1570 |
990-993 |
NNP |
denotes |
han |
T1572 |
994-996 |
FW |
denotes |
et |
T1573 |
997-999 |
FW |
denotes |
al |
T1574 |
1000-1001 |
-LRB- |
denotes |
[ |
T1575 |
1001-1003 |
CD |
denotes |
24 |
T1576 |
1003-1004 |
-RRB- |
denotes |
] |
T1577 |
1004-1006 |
, |
denotes |
, |
T1578 |
1006-1009 |
DT |
denotes |
the |
T1579 |
1010-1017 |
NNS |
denotes |
results |
T1563 |
1018-1023 |
VBP |
denotes |
raise |
T1580 |
1024-1027 |
DT |
denotes |
the |
T1581 |
1028-1039 |
NN |
denotes |
possibility |
T1582 |
1040-1044 |
IN |
denotes |
that |
T1584 |
1045-1050 |
NN |
denotes |
CAPAN |
T1586 |
1050-1051 |
HYPH |
denotes |
- |
T1587 |
1051-1052 |
CD |
denotes |
1 |
T1585 |
1053-1058 |
NNS |
denotes |
cells |
T1583 |
1059-1063 |
VBP |
denotes |
have |
T1588 |
1064-1068 |
JJR |
denotes |
more |
T1590 |
1069-1073 |
IN |
denotes |
than |
T1589 |
1074-1077 |
CD |
denotes |
one |
T1591 |
1078-1086 |
NN |
denotes |
mutation |
T1592 |
1087-1091 |
WDT |
denotes |
that |
T1593 |
1092-1098 |
VBZ |
denotes |
lowers |
T1594 |
1099-1102 |
DT |
denotes |
the |
T1595 |
1103-1113 |
NN |
denotes |
efficiency |
T1596 |
1114-1116 |
IN |
denotes |
of |
T1597 |
1117-1132 |
JJ |
denotes |
recombinational |
T1598 |
1133-1139 |
NN |
denotes |
repair |
T1599 |
1140-1148 |
JJ |
denotes |
relative |
T1600 |
1149-1151 |
IN |
denotes |
to |
T1601 |
1152-1156 |
DT |
denotes |
that |
T1602 |
1157-1165 |
VBN |
denotes |
observed |
T1603 |
1166-1168 |
IN |
denotes |
in |
T1604 |
1169-1174 |
JJ |
denotes |
other |
T1606 |
1175-1180 |
JJ |
denotes |
human |
T1607 |
1181-1185 |
NN |
denotes |
cell |
T1605 |
1186-1191 |
NNS |
denotes |
lines |
T1608 |
1191-1192 |
. |
denotes |
. |
T1609 |
1192-1373 |
sentence |
denotes |
Conversely, the BRCA2 defect in CAPAN-1 could be fully responsible for the 100-fold defect in recombination if the level of BRCA2 complementation observed by Powell was incomplete. |
T1610 |
1193-1203 |
RB |
denotes |
Conversely |
T1612 |
1203-1205 |
, |
denotes |
, |
T1613 |
1205-1208 |
DT |
denotes |
the |
T1615 |
1209-1214 |
NN |
denotes |
BRCA2 |
T1614 |
1215-1221 |
NN |
denotes |
defect |
T1616 |
1222-1224 |
IN |
denotes |
in |
T1617 |
1225-1230 |
NN |
denotes |
CAPAN |
T1618 |
1230-1231 |
HYPH |
denotes |
- |
T1619 |
1231-1232 |
CD |
denotes |
1 |
T1620 |
1233-1238 |
MD |
denotes |
could |
T1611 |
1239-1241 |
VB |
denotes |
be |
T1621 |
1242-1247 |
RB |
denotes |
fully |
T1622 |
1248-1259 |
JJ |
denotes |
responsible |
T1623 |
1260-1263 |
IN |
denotes |
for |
T1624 |
1264-1267 |
DT |
denotes |
the |
T1626 |
1268-1276 |
JJ |
denotes |
100-fold |
T1625 |
1277-1283 |
NN |
denotes |
defect |
T1627 |
1284-1286 |
IN |
denotes |
in |
T1628 |
1287-1300 |
NN |
denotes |
recombination |
T1629 |
1301-1303 |
IN |
denotes |
if |
T1631 |
1304-1307 |
DT |
denotes |
the |
T1632 |
1308-1313 |
NN |
denotes |
level |
T1633 |
1314-1316 |
IN |
denotes |
of |
T1634 |
1317-1322 |
NN |
denotes |
BRCA2 |
T1635 |
1323-1338 |
NN |
denotes |
complementation |
T1636 |
1339-1347 |
VBN |
denotes |
observed |
T1637 |
1348-1350 |
IN |
denotes |
by |
T1638 |
1351-1357 |
NNP |
denotes |
Powell |
T1630 |
1358-1361 |
VBD |
denotes |
was |
T1639 |
1362-1372 |
JJ |
denotes |
incomplete |
T1640 |
1372-1373 |
. |
denotes |
. |
T1641 |
1373-1666 |
sentence |
denotes |
Furthermore, the discrepancy between the 100-fold difference between CAPAN-1 and the other human lines as compared with the fivefold to sixfold difference between the Brca2lex1/lex2cells and Brca2+/+ ES cells might simply be accounted for by the fact that Brca2lex1/lex2 is not a null allele. |
T1642 |
1374-1385 |
RB |
denotes |
Furthermore |
T1644 |
1385-1387 |
, |
denotes |
, |
T1645 |
1387-1390 |
DT |
denotes |
the |
T1646 |
1391-1402 |
NN |
denotes |
discrepancy |
T1647 |
1403-1410 |
IN |
denotes |
between |
T1648 |
1411-1414 |
DT |
denotes |
the |
T1650 |
1415-1423 |
JJ |
denotes |
100-fold |
T1649 |
1424-1434 |
NN |
denotes |
difference |
T1651 |
1435-1442 |
IN |
denotes |
between |
T1652 |
1443-1448 |
NN |
denotes |
CAPAN |
T1653 |
1448-1449 |
HYPH |
denotes |
- |
T1654 |
1449-1450 |
CD |
denotes |
1 |
T1655 |
1451-1454 |
CC |
denotes |
and |
T1656 |
1455-1458 |
DT |
denotes |
the |
T1658 |
1459-1464 |
JJ |
denotes |
other |
T1659 |
1465-1470 |
JJ |
denotes |
human |
T1657 |
1471-1476 |
NNS |
denotes |
lines |
T1660 |
1477-1479 |
IN |
denotes |
as |
T1661 |
1480-1488 |
VBN |
denotes |
compared |
T1662 |
1489-1493 |
IN |
denotes |
with |
T1663 |
1494-1497 |
DT |
denotes |
the |
T1665 |
1498-1506 |
JJ |
denotes |
fivefold |
T1667 |
1507-1509 |
IN |
denotes |
to |
T1666 |
1510-1517 |
JJ |
denotes |
sixfold |
T1664 |
1518-1528 |
NN |
denotes |
difference |
T1668 |
1529-1536 |
IN |
denotes |
between |
T1669 |
1537-1540 |
DT |
denotes |
the |
T1671 |
1541-1550 |
NN |
denotes |
Brca2lex1 |
T1673 |
1550-1551 |
HYPH |
denotes |
/ |
T1672 |
1551-1555 |
NN |
denotes |
lex2 |
T1670 |
1555-1560 |
NNS |
denotes |
cells |
T1674 |
1561-1564 |
CC |
denotes |
and |
T1675 |
1565-1570 |
NN |
denotes |
Brca2 |
T1677 |
1570-1571 |
SYM |
denotes |
+ |
T1678 |
1571-1572 |
HYPH |
denotes |
/ |
T1679 |
1572-1573 |
SYM |
denotes |
+ |
T1680 |
1574-1576 |
NN |
denotes |
ES |
T1676 |
1577-1582 |
NNS |
denotes |
cells |
T1681 |
1583-1588 |
MD |
denotes |
might |
T1682 |
1589-1595 |
RB |
denotes |
simply |
T1683 |
1596-1598 |
VB |
denotes |
be |
T1643 |
1599-1608 |
VBN |
denotes |
accounted |
T1684 |
1609-1612 |
IN |
denotes |
for |
T1685 |
1613-1615 |
IN |
denotes |
by |
T1686 |
1616-1619 |
DT |
denotes |
the |
T1687 |
1620-1624 |
NN |
denotes |
fact |
T1688 |
1625-1629 |
IN |
denotes |
that |
T1690 |
1630-1639 |
NN |
denotes |
Brca2lex1 |
T1692 |
1639-1640 |
HYPH |
denotes |
/ |
T1691 |
1640-1644 |
NN |
denotes |
lex2 |
T1689 |
1645-1647 |
VBZ |
denotes |
is |
T1693 |
1648-1651 |
RB |
denotes |
not |
T1694 |
1652-1653 |
DT |
denotes |
a |
T1696 |
1654-1658 |
JJ |
denotes |
null |
T1695 |
1659-1665 |
NN |
denotes |
allele |
T1697 |
1665-1666 |
. |
denotes |
. |
T1698 |
1666-1773 |
sentence |
denotes |
Additional studies are likely to shed light on the efficiency of BRCA2-independent recombination pathways. |
T1699 |
1667-1677 |
JJ |
denotes |
Additional |
T1700 |
1678-1685 |
NNS |
denotes |
studies |
T1701 |
1686-1689 |
VBP |
denotes |
are |
T1702 |
1690-1696 |
JJ |
denotes |
likely |
T1703 |
1697-1699 |
TO |
denotes |
to |
T1704 |
1700-1704 |
VB |
denotes |
shed |
T1705 |
1705-1710 |
NN |
denotes |
light |
T1706 |
1711-1713 |
IN |
denotes |
on |
T1707 |
1714-1717 |
DT |
denotes |
the |
T1708 |
1718-1728 |
NN |
denotes |
efficiency |
T1709 |
1729-1731 |
IN |
denotes |
of |
T1710 |
1732-1737 |
NN |
denotes |
BRCA2 |
T1712 |
1737-1738 |
HYPH |
denotes |
- |
T1711 |
1738-1749 |
JJ |
denotes |
independent |
T1714 |
1750-1763 |
NN |
denotes |
recombination |
T1713 |
1764-1772 |
NNS |
denotes |
pathways |
T1715 |
1772-1773 |
. |
denotes |
. |
T1716 |
1773-1907 |
sentence |
denotes |
Taken together, the results indicate that BRCA2 is indeed required for high levels of recombinational repair in both human and mouse. |
T1717 |
1774-1779 |
VBN |
denotes |
Taken |
T1719 |
1780-1788 |
RB |
denotes |
together |
T1720 |
1788-1790 |
, |
denotes |
, |
T1721 |
1790-1793 |
DT |
denotes |
the |
T1722 |
1794-1801 |
NNS |
denotes |
results |
T1718 |
1802-1810 |
VBP |
denotes |
indicate |
T1723 |
1811-1815 |
IN |
denotes |
that |
T1725 |
1816-1821 |
NN |
denotes |
BRCA2 |
T1726 |
1822-1824 |
VBZ |
denotes |
is |
T1727 |
1825-1831 |
RB |
denotes |
indeed |
T1724 |
1832-1840 |
VBN |
denotes |
required |
T1728 |
1841-1844 |
IN |
denotes |
for |
T1729 |
1845-1849 |
JJ |
denotes |
high |
T1730 |
1850-1856 |
NNS |
denotes |
levels |
T1731 |
1857-1859 |
IN |
denotes |
of |
T1732 |
1860-1875 |
JJ |
denotes |
recombinational |
T1733 |
1876-1882 |
NN |
denotes |
repair |
T1734 |
1883-1885 |
IN |
denotes |
in |
T1735 |
1886-1890 |
CC |
denotes |
both |
T1737 |
1891-1896 |
JJ |
denotes |
human |
T1738 |
1897-1900 |
CC |
denotes |
and |
T1736 |
1901-1906 |
NN |
denotes |
mouse |
T1739 |
1906-1907 |
. |
denotes |
. |
R1000 |
T1467 |
T1469 |
compound |
length,BRCA2 |
R1001 |
T1468 |
T1467 |
punct |
-,length |
R1002 |
T1469 |
T1465 |
dobj |
BRCA2,expressing |
R1003 |
T1470 |
T1471 |
punct |
(,was |
R1004 |
T1471 |
T1469 |
parataxis |
was,BRCA2 |
R1005 |
T1472 |
T1473 |
det |
the,defect |
R1006 |
T1473 |
T1471 |
nsubj |
defect,was |
R1007 |
T1474 |
T1473 |
acl |
observed,defect |
R1008 |
T1475 |
T1476 |
advmod |
about,sixfold |
R1009 |
T1476 |
T1471 |
advmod |
sixfold,was |
R1010 |
T1477 |
T1476 |
advmod |
fivefold,sixfold |
R1011 |
T1478 |
T1476 |
quantmod |
to,sixfold |
R1012 |
T1479 |
T1471 |
punct |
),was |
R1013 |
T1480 |
T1455 |
punct |
.,found |
R1014 |
T1482 |
T1483 |
advmod |
Second,was |
R1015 |
T1484 |
T1483 |
punct |
", ",was |
R1016 |
T1485 |
T1483 |
prep |
in,was |
R1017 |
T1486 |
T1487 |
det |
an,study |
R1018 |
T1487 |
T1485 |
pobj |
study,in |
R1019 |
T1488 |
T1487 |
amod |
independent,study |
R1020 |
T1489 |
T1483 |
punct |
", ",was |
R1021 |
T1490 |
T1483 |
nsubj |
Powell,was |
R1022 |
T1491 |
T1483 |
acomp |
able,was |
R1023 |
T1492 |
T1493 |
aux |
to,compare |
R1024 |
T1493 |
T1491 |
xcomp |
compare,able |
R1025 |
T1494 |
T1493 |
dobj |
derivatives,compare |
R1026 |
T1495 |
T1494 |
prep |
of,derivatives |
R1027 |
T1496 |
T1495 |
pobj |
CAPAN,of |
R1028 |
T1497 |
T1496 |
punct |
-,CAPAN |
R1029 |
T1498 |
T1496 |
nummod |
1,CAPAN |
R1030 |
T1499 |
T1500 |
dep |
that,differed |
R1031 |
T1500 |
T1494 |
relcl |
differed,derivatives |
R1032 |
T1501 |
T1500 |
advmod |
only,differed |
R1033 |
T1502 |
T1500 |
prep |
in,differed |
R1034 |
T1503 |
T1504 |
poss |
their,ability |
R1035 |
T1504 |
T1502 |
pobj |
ability,in |
R1036 |
T1505 |
T1506 |
aux |
to,express |
R1037 |
T1506 |
T1504 |
acl |
express,ability |
R1038 |
T1507 |
T1508 |
amod |
full,length |
R1039 |
T1508 |
T1510 |
compound |
length,protein |
R1040 |
T1509 |
T1508 |
punct |
-,length |
R1041 |
T1510 |
T1506 |
dobj |
protein,express |
R1042 |
T1511 |
T1510 |
compound |
BRCA2,protein |
R1043 |
T1512 |
T1513 |
punct |
(,Powell |
R1044 |
T1513 |
T1493 |
meta |
Powell,compare |
R1045 |
T1514 |
T1513 |
compound |
S.,Powell |
R1046 |
T1515 |
T1513 |
punct |
", ",Powell |
R1047 |
T1516 |
T1517 |
amod |
personal,communication |
R1048 |
T1517 |
T1513 |
dep |
communication,Powell |
R1049 |
T1518 |
T1513 |
punct |
", ",Powell |
R1050 |
T1519 |
T1513 |
npadvmod |
2001,Powell |
R1051 |
T1520 |
T1513 |
punct |
),Powell |
R1052 |
T1521 |
T1483 |
punct |
.,was |
R1053 |
T1523 |
T1524 |
prep |
In,yielded |
R1054 |
T1525 |
T1526 |
det |
these,experiments |
R1055 |
T1526 |
T1523 |
pobj |
experiments,In |
R1056 |
T1527 |
T1524 |
punct |
", ",yielded |
R1057 |
T1528 |
T1529 |
det |
the,derivative |
R1058 |
T1529 |
T1524 |
nsubj |
derivative,yielded |
R1059 |
T1530 |
T1529 |
acl |
expressing,derivative |
R1060 |
T1531 |
T1532 |
amod |
full,length |
R1061 |
T1532 |
T1534 |
compound |
length,BRCA2 |
R1062 |
T1533 |
T1532 |
punct |
-,length |
R1063 |
T1534 |
T1530 |
dobj |
BRCA2,expressing |
R1064 |
T1535 |
T1536 |
advmod |
10-fold,more |
R1065 |
T1536 |
T1537 |
amod |
more,recombinants |
R1066 |
T1537 |
T1524 |
dobj |
recombinants,yielded |
R1067 |
T1538 |
T1537 |
prep |
than,recombinants |
R1068 |
T1539 |
T1538 |
pobj |
controls,than |
R1069 |
T1540 |
T1539 |
acl |
expressing,controls |
R1070 |
T1541 |
T1542 |
advmod |
only,BRCA2 |
R1071 |
T1542 |
T1540 |
dobj |
BRCA2,expressing |
R1072 |
T1543 |
T1542 |
amod |
truncated,BRCA2 |
R1073 |
T1544 |
T1545 |
punct |
(,Powell |
R1074 |
T1545 |
T1524 |
meta |
Powell,yielded |
R1075 |
T1546 |
T1545 |
compound |
S.,Powell |
R1076 |
T1547 |
T1545 |
punct |
", ",Powell |
R1077 |
T1548 |
T1549 |
amod |
personal,communication |
R1078 |
T1549 |
T1545 |
dep |
communication,Powell |
R1079 |
T1550 |
T1545 |
punct |
", ",Powell |
R1080 |
T1551 |
T1545 |
dep |
2001,Powell |
R1081 |
T1552 |
T1545 |
punct |
),Powell |
R1082 |
T1553 |
T1524 |
punct |
.,yielded |
R1083 |
T1555 |
T1556 |
mark |
While,was |
R1084 |
T1556 |
T1563 |
advcl |
was,raise |
R1085 |
T1557 |
T1558 |
det |
the,design |
R1086 |
T1558 |
T1556 |
nsubj |
design,was |
R1087 |
T1559 |
T1558 |
amod |
experimental,design |
R1088 |
T1560 |
T1558 |
prep |
of,design |
R1089 |
T1561 |
T1562 |
det |
these,experiments |
R1090 |
T1562 |
T1560 |
pobj |
experiments,of |
R1091 |
T1564 |
T1565 |
advmod |
somewhat,different |
R1092 |
T1565 |
T1556 |
acomp |
different,was |
R1093 |
T1566 |
T1565 |
prep |
from,different |
R1094 |
T1567 |
T1566 |
pobj |
that,from |
R1095 |
T1568 |
T1567 |
prep |
of,that |
R1096 |
T1569 |
T1570 |
compound |
Moyna,han |
R1097 |
T1570 |
T1568 |
pobj |
han,of |
R1098 |
T1571 |
T1570 |
punct |
-,han |
R1099 |
T1572 |
T1573 |
advmod |
et,al |
R1100 |
T1573 |
T1570 |
advmod |
al,han |
R1101 |
T1574 |
T1575 |
punct |
[,24 |
R1102 |
T1575 |
T1570 |
parataxis |
24,han |
R1103 |
T1576 |
T1575 |
punct |
],24 |
R1104 |
T1577 |
T1563 |
punct |
", ",raise |
R1105 |
T1578 |
T1579 |
det |
the,results |
R1106 |
T1579 |
T1563 |
nsubj |
results,raise |
R1107 |
T1580 |
T1581 |
det |
the,possibility |
R1108 |
T1581 |
T1563 |
dobj |
possibility,raise |
R1109 |
T1582 |
T1583 |
mark |
that,have |
R1110 |
T1583 |
T1581 |
acl |
have,possibility |
R1111 |
T1584 |
T1585 |
nmod |
CAPAN,cells |
R1112 |
T1585 |
T1583 |
nsubj |
cells,have |
R1113 |
T1586 |
T1584 |
punct |
-,CAPAN |
R1114 |
T1587 |
T1584 |
nummod |
1,CAPAN |
R1115 |
T1588 |
T1589 |
amod |
more,one |
R1116 |
T1589 |
T1591 |
nummod |
one,mutation |
R1117 |
T1590 |
T1589 |
quantmod |
than,one |
R1118 |
T1591 |
T1583 |
dobj |
mutation,have |
R1119 |
T1592 |
T1593 |
dep |
that,lowers |
R1120 |
T1593 |
T1591 |
relcl |
lowers,mutation |
R1121 |
T1594 |
T1595 |
det |
the,efficiency |
R1122 |
T1595 |
T1593 |
dobj |
efficiency,lowers |
R1123 |
T1596 |
T1595 |
prep |
of,efficiency |
R1124 |
T1597 |
T1598 |
amod |
recombinational,repair |
R1125 |
T1598 |
T1596 |
pobj |
repair,of |
R1126 |
T1599 |
T1598 |
amod |
relative,repair |
R1127 |
T1600 |
T1599 |
prep |
to,relative |
R1128 |
T1601 |
T1600 |
pobj |
that,to |
R1129 |
T1602 |
T1601 |
acl |
observed,that |
R1130 |
T1603 |
T1602 |
prep |
in,observed |
R1131 |
T1604 |
T1605 |
amod |
other,lines |
R1132 |
T1605 |
T1603 |
pobj |
lines,in |
R1133 |
T1606 |
T1605 |
amod |
human,lines |
R1134 |
T1607 |
T1605 |
compound |
cell,lines |
R1135 |
T1608 |
T1563 |
punct |
.,raise |
R1136 |
T1610 |
T1611 |
advmod |
Conversely,be |
R1137 |
T1612 |
T1611 |
punct |
", ",be |
R1138 |
T1613 |
T1614 |
det |
the,defect |
R1139 |
T1614 |
T1611 |
nsubj |
defect,be |
R1140 |
T1615 |
T1614 |
compound |
BRCA2,defect |
R1141 |
T1616 |
T1614 |
prep |
in,defect |
R1142 |
T1617 |
T1616 |
pobj |
CAPAN,in |
R1143 |
T1618 |
T1617 |
punct |
-,CAPAN |
R1144 |
T1619 |
T1617 |
nummod |
1,CAPAN |
R1145 |
T1621 |
T1622 |
advmod |
fully,responsible |
R1146 |
T1622 |
T1611 |
acomp |
responsible,be |
R1147 |
T1623 |
T1622 |
prep |
for,responsible |
R1148 |
T1624 |
T1625 |
det |
the,defect |
R1149 |
T1625 |
T1623 |
pobj |
defect,for |
R1150 |
T1620 |
T1611 |
aux |
could,be |
R1151 |
T1627 |
T1625 |
prep |
in,defect |
R1152 |
T1628 |
T1627 |
pobj |
recombination,in |
R1153 |
T1626 |
T1625 |
amod |
100-fold,defect |
R1154 |
T1630 |
T1611 |
advcl |
was,be |
R1155 |
T1631 |
T1632 |
det |
the,level |
R1156 |
T1629 |
T1630 |
mark |
if,was |
R1157 |
T1633 |
T1632 |
prep |
of,level |
R1158 |
T1634 |
T1635 |
compound |
BRCA2,complementation |
R1159 |
T1632 |
T1630 |
nsubj |
level,was |
R1160 |
T1636 |
T1632 |
acl |
observed,level |
R1161 |
T1637 |
T1636 |
agent |
by,observed |
R1162 |
T1638 |
T1637 |
pobj |
Powell,by |
R1163 |
T1639 |
T1630 |
acomp |
incomplete,was |
R1164 |
T1635 |
T1633 |
pobj |
complementation,of |
R1165 |
T1642 |
T1643 |
advmod |
Furthermore,accounted |
R1166 |
T1640 |
T1611 |
punct |
.,be |
R1167 |
T1644 |
T1643 |
punct |
", ",accounted |
R1168 |
T1645 |
T1646 |
det |
the,discrepancy |
R1169 |
T1647 |
T1646 |
prep |
between,discrepancy |
R1170 |
T1648 |
T1649 |
det |
the,difference |
R1171 |
T1646 |
T1643 |
nsubjpass |
discrepancy,accounted |
R1172 |
T1650 |
T1649 |
amod |
100-fold,difference |
R1173 |
T1651 |
T1649 |
prep |
between,difference |
R1174 |
T1649 |
T1647 |
pobj |
difference,between |
R1175 |
T1653 |
T1652 |
punct |
-,CAPAN |
R1176 |
T1654 |
T1652 |
nummod |
1,CAPAN |
R1177 |
T1652 |
T1651 |
pobj |
CAPAN,between |
R1178 |
T1656 |
T1657 |
det |
the,lines |
R1179 |
T1657 |
T1652 |
conj |
lines,CAPAN |
R1180 |
T1655 |
T1652 |
cc |
and,CAPAN |
R1181 |
T1659 |
T1657 |
amod |
human,lines |
R1182 |
T1660 |
T1646 |
prep |
as,discrepancy |
R1183 |
T1658 |
T1657 |
amod |
other,lines |
R1184 |
T1662 |
T1661 |
prep |
with,compared |
R1185 |
T1661 |
T1660 |
prep |
compared,as |
R1186 |
T1664 |
T1662 |
pobj |
difference,with |
R1187 |
T1663 |
T1664 |
det |
the,difference |
R1188 |
T1666 |
T1664 |
nummod |
sixfold,difference |
R1189 |
T1665 |
T1666 |
amod |
fivefold,sixfold |
R1190 |
T1668 |
T1664 |
prep |
between,difference |
R1191 |
T1669 |
T1670 |
det |
the,cells |
R1192 |
T1667 |
T1666 |
quantmod |
to,sixfold |
R1193 |
T1671 |
T1672 |
compound |
Brca2lex1,lex2 |
R1194 |
T1672 |
T1670 |
compound |
lex2,cells |
R1195 |
T1670 |
T1668 |
pobj |
cells,between |
R1196 |
T1674 |
T1670 |
cc |
and,cells |
R1197 |
T1675 |
T1676 |
nmod |
Brca2,cells |
R1198 |
T1673 |
T1672 |
punct |
/,lex2 |
R1199 |
T1677 |
T1675 |
punct |
+,Brca2 |
R1200 |
T1678 |
T1675 |
punct |
/,Brca2 |
R1201 |
T1679 |
T1675 |
punct |
+,Brca2 |
R1202 |
T1676 |
T1670 |
conj |
cells,cells |
R1203 |
T1681 |
T1643 |
aux |
might,accounted |
R1204 |
T1682 |
T1643 |
advmod |
simply,accounted |
R1205 |
T1680 |
T1676 |
compound |
ES,cells |
R1206 |
T1684 |
T1643 |
prep |
for,accounted |
R1207 |
T1685 |
T1643 |
prep |
by,accounted |
R1208 |
T1683 |
T1643 |
auxpass |
be,accounted |
R1209 |
T1687 |
T1685 |
pobj |
fact,by |
R1210 |
T1688 |
T1689 |
mark |
that,is |
R1211 |
T1686 |
T1687 |
det |
the,fact |
R1212 |
T1690 |
T1691 |
compound |
Brca2lex1,lex2 |
R1213 |
T1691 |
T1689 |
nsubj |
lex2,is |
R1214 |
T1689 |
T1687 |
acl |
is,fact |
R1215 |
T1693 |
T1689 |
neg |
not,is |
R1216 |
T1694 |
T1695 |
det |
a,allele |
R1217 |
T1692 |
T1691 |
punct |
/,lex2 |
R1218 |
T1696 |
T1695 |
amod |
null,allele |
R1219 |
T1697 |
T1643 |
punct |
.,accounted |
R1220 |
T1695 |
T1689 |
attr |
allele,is |
R1221 |
T1699 |
T1700 |
amod |
Additional,studies |
R1222 |
T1700 |
T1701 |
nsubj |
studies,are |
R1223 |
T1702 |
T1701 |
acomp |
likely,are |
R1224 |
T1704 |
T1702 |
xcomp |
shed,likely |
R1225 |
T1705 |
T1704 |
dobj |
light,shed |
R1226 |
T1703 |
T1704 |
aux |
to,shed |
R1227 |
T1707 |
T1708 |
det |
the,efficiency |
R1228 |
T1708 |
T1706 |
pobj |
efficiency,on |
R1229 |
T1706 |
T1704 |
prep |
on,shed |
R1230 |
T1710 |
T1711 |
npadvmod |
BRCA2,independent |
R1231 |
T1711 |
T1713 |
amod |
independent,pathways |
R1232 |
T1709 |
T1708 |
prep |
of,efficiency |
R1233 |
T1713 |
T1709 |
pobj |
pathways,of |
R1234 |
T1714 |
T1713 |
compound |
recombination,pathways |
R1235 |
T1712 |
T1711 |
punct |
-,independent |
R1236 |
T1719 |
T1717 |
advmod |
together,Taken |
R1237 |
T1715 |
T1701 |
punct |
.,are |
R1238 |
T1720 |
T1718 |
punct |
", ",indicate |
R1239 |
T1717 |
T1718 |
advcl |
Taken,indicate |
R1240 |
T1722 |
T1718 |
nsubj |
results,indicate |
R1241 |
T1721 |
T1722 |
det |
the,results |
R1242 |
T1724 |
T1718 |
ccomp |
required,indicate |
R1243 |
T1725 |
T1724 |
nsubjpass |
BRCA2,required |
R1244 |
T1723 |
T1724 |
mark |
that,required |
R1245 |
T1727 |
T1724 |
advmod |
indeed,required |
R1246 |
T1728 |
T1724 |
prep |
for,required |
R1247 |
T1726 |
T1724 |
auxpass |
is,required |
R1248 |
T1730 |
T1728 |
pobj |
levels,for |
R1249 |
T1729 |
T1730 |
amod |
high,levels |
R1250 |
T1732 |
T1733 |
amod |
recombinational,repair |
R1251 |
T1733 |
T1731 |
pobj |
repair,of |
R1252 |
T1731 |
T1730 |
prep |
of,levels |
R1253 |
T1735 |
T1736 |
preconj |
both,mouse |
R1254 |
T1734 |
T1724 |
prep |
in,required |
R1255 |
T1737 |
T1736 |
amod |
human,mouse |
R1256 |
T1738 |
T1736 |
cc |
and,mouse |
R1257 |
T1736 |
T1734 |
pobj |
mouse,in |
R1258 |
T1739 |
T1718 |
punct |
.,indicate |
R924 |
T1386 |
T1387 |
mark |
While,were |
R925 |
T1387 |
T1391 |
advcl |
were,argue |
R926 |
T1388 |
T1387 |
nsubj |
Moynahan,were |
R927 |
T1389 |
T1390 |
advmod |
et,al |
R928 |
T1390 |
T1388 |
advmod |
al,Moynahan |
R929 |
T1392 |
T1387 |
acomp |
careful,were |
R930 |
T1393 |
T1394 |
aux |
to,point |
R931 |
T1394 |
T1392 |
xcomp |
point,careful |
R932 |
T1395 |
T1394 |
prt |
out,point |
R933 |
T1396 |
T1397 |
det |
this,problem |
R934 |
T1397 |
T1394 |
dobj |
problem,point |
R935 |
T1398 |
T1391 |
punct |
", ",argue |
R936 |
T1399 |
T1400 |
nummod |
two,sets |
R937 |
T1400 |
T1391 |
nsubj |
sets,argue |
R938 |
T1401 |
T1400 |
prep |
of,sets |
R939 |
T1402 |
T1401 |
pobj |
results,of |
R940 |
T1403 |
T1391 |
prep |
against,argue |
R941 |
T1404 |
T1405 |
det |
the,possibility |
R942 |
T1405 |
T1403 |
pobj |
possibility,against |
R943 |
T1406 |
T1407 |
mark |
that,is |
R944 |
T1407 |
T1405 |
acl |
is,possibility |
R945 |
T1408 |
T1409 |
det |
the,deficiency |
R946 |
T1409 |
T1407 |
nsubj |
deficiency,is |
R947 |
T1410 |
T1409 |
amod |
recombinational,deficiency |
R948 |
T1411 |
T1409 |
compound |
repair,deficiency |
R949 |
T1412 |
T1409 |
prep |
of,deficiency |
R950 |
T1413 |
T1414 |
nmod |
CAPAN,cells |
R951 |
T1414 |
T1412 |
pobj |
cells,of |
R952 |
T1415 |
T1413 |
punct |
-,CAPAN |
R953 |
T1416 |
T1413 |
nummod |
1,CAPAN |
R954 |
T1417 |
T1418 |
advmod |
completely,independent |
R955 |
T1418 |
T1407 |
acomp |
independent,is |
R956 |
T1419 |
T1418 |
prep |
of,independent |
R957 |
T1420 |
T1421 |
poss |
its,defect |
R958 |
T1421 |
T1419 |
pobj |
defect,of |
R959 |
T1422 |
T1421 |
prep |
in,defect |
R960 |
T1423 |
T1422 |
pobj |
BRCA2,in |
R961 |
T1424 |
T1391 |
punct |
.,argue |
R962 |
T1426 |
T1427 |
advmod |
First,measured |
R963 |
T1428 |
T1427 |
punct |
", ",measured |
R964 |
T1429 |
T1427 |
prep |
in,measured |
R965 |
T1430 |
T1431 |
det |
the,study |
R966 |
T1431 |
T1429 |
pobj |
study,in |
R967 |
T1432 |
T1431 |
amod |
same,study |
R968 |
T1433 |
T1434 |
punct |
[,24 |
R969 |
T1434 |
T1431 |
parataxis |
24,study |
R970 |
T1435 |
T1434 |
punct |
],24 |
R971 |
T1436 |
T1427 |
punct |
", ",measured |
R972 |
T1437 |
T1427 |
nsubjpass |
recombination,measured |
R973 |
T1438 |
T1437 |
prep |
in,recombination |
R974 |
T1439 |
T1440 |
det |
a,line |
R975 |
T1440 |
T1438 |
pobj |
line,in |
R976 |
T1441 |
T1440 |
compound |
mouse,line |
R977 |
T1442 |
T1440 |
compound |
ES,line |
R978 |
T1443 |
T1440 |
compound |
cell,line |
R979 |
T1444 |
T1445 |
dep |
that,expresses |
R980 |
T1445 |
T1440 |
relcl |
expresses,line |
R981 |
T1446 |
T1447 |
advmod |
only,protein |
R982 |
T1447 |
T1445 |
dobj |
protein,expresses |
R983 |
T1448 |
T1447 |
amod |
truncated,protein |
R984 |
T1449 |
T1447 |
compound |
BRCA2,protein |
R985 |
T1450 |
T1427 |
auxpass |
was,measured |
R986 |
T1451 |
T1427 |
punct |
.,measured |
R987 |
T1453 |
T1454 |
det |
This,line |
R988 |
T1454 |
T1455 |
nsubjpass |
line,found |
R989 |
T1456 |
T1455 |
auxpass |
was,found |
R990 |
T1457 |
T1458 |
aux |
to,have |
R991 |
T1458 |
T1455 |
xcomp |
have,found |
R992 |
T1459 |
T1460 |
amod |
lower,efficiency |
R993 |
T1460 |
T1458 |
dobj |
efficiency,have |
R994 |
T1461 |
T1460 |
compound |
recombination,efficiency |
R995 |
T1462 |
T1460 |
prep |
than,efficiency |
R996 |
T1463 |
T1464 |
amod |
isogenic,cells |
R997 |
T1464 |
T1462 |
pobj |
cells,than |
R998 |
T1465 |
T1464 |
acl |
expressing,cells |
R999 |
T1466 |
T1467 |
amod |
full,length |