craft-sa-dev Home  

PMC:138691 / 4119-4788 JSONTXT 4 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T1187 0-669 sentence denotes Figure 1 Recombination substrates used for assaying homology-directed repair. Cutting at the I-SceI site within the mutant GFP (SceGFP) results in a double-strand break that can be repaired through homologous gene conversion using a 3'-truncated copy of GFP as sequence donor. The mechanism results in the formation of a functional copy of the GFP gene. The model shown assumes gene conversion occurs via the synthesis-dependent annealing mechanism. Moynahan et al [24] have used such a GFP recombination substrate to demonstrate that cells with defective BRCA2 protein are deficient in their ability to repair the I-SceI-induced DSB through homologous recombination.
T1188 452-460 NNP denotes Moynahan
T1190 461-463 FW denotes et
T1191 464-466 FW denotes al
T1192 467-468 -LRB- denotes [
T1193 468-470 CD denotes 24
T1194 470-471 -RRB- denotes ]
T1195 472-476 VBP denotes have
T1189 477-481 VBN denotes used
T1196 482-486 PDT denotes such
T1198 487-488 DT denotes a
T1199 489-492 NN denotes GFP
T1200 493-506 NN denotes recombination
T1197 507-516 NN denotes substrate
T1201 517-519 TO denotes to
T1202 520-531 VB denotes demonstrate
T1203 532-536 IN denotes that
T1205 537-542 NNS denotes cells
T1206 543-547 IN denotes with
T1207 548-557 JJ denotes defective
T1209 558-563 NN denotes BRCA2
T1208 564-571 NN denotes protein
T1204 572-575 VBP denotes are
T1210 576-585 JJ denotes deficient
T1211 586-588 IN denotes in
T1212 589-594 PRP$ denotes their
T1213 595-602 NN denotes ability
T1214 603-605 TO denotes to
T1215 606-612 VB denotes repair
T1216 613-616 DT denotes the
T1218 617-618 NN denotes I
T1220 618-619 HYPH denotes -
T1219 619-623 NN denotes SceI
T1222 623-624 HYPH denotes -
T1221 624-631 VBN denotes induced
T1217 632-635 NN denotes DSB
T1223 636-643 IN denotes through
T1224 644-654 JJ denotes homologous
T1225 655-668 NN denotes recombination
T1226 668-669 . denotes .
R738 T1188 T1189 nsubj Moynahan,used
R739 T1190 T1191 advmod et,al
R740 T1191 T1188 advmod al,Moynahan
R741 T1192 T1193 punct [,24
R742 T1193 T1188 parataxis 24,Moynahan
R743 T1194 T1193 punct ],24
R744 T1195 T1189 aux have,used
R745 T1196 T1197 predet such,substrate
R746 T1197 T1189 dobj substrate,used
R747 T1198 T1197 det a,substrate
R748 T1199 T1200 compound GFP,recombination
R749 T1200 T1197 compound recombination,substrate
R750 T1201 T1202 aux to,demonstrate
R751 T1202 T1189 advcl demonstrate,used
R752 T1203 T1204 mark that,are
R753 T1204 T1202 ccomp are,demonstrate
R754 T1205 T1204 nsubj cells,are
R755 T1206 T1205 prep with,cells
R756 T1207 T1208 amod defective,protein
R757 T1208 T1206 pobj protein,with
R758 T1209 T1208 compound BRCA2,protein
R759 T1210 T1204 acomp deficient,are
R760 T1211 T1210 prep in,deficient
R761 T1212 T1213 poss their,ability
R762 T1213 T1211 pobj ability,in
R763 T1214 T1215 aux to,repair
R764 T1215 T1213 acl repair,ability
R765 T1216 T1217 det the,DSB
R766 T1217 T1215 dobj DSB,repair
R767 T1218 T1219 compound I,SceI
R768 T1219 T1221 npadvmod SceI,induced
R769 T1220 T1219 punct -,SceI
R770 T1221 T1217 amod induced,DSB
R771 T1222 T1221 punct -,induced
R772 T1223 T1215 prep through,repair
R773 T1224 T1225 amod homologous,recombination
R774 T1225 T1223 pobj recombination,through
R775 T1226 T1189 punct .,used