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PMC:138691 / 13042-14123 JSONTXT 4 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T3007 0-7 RB denotes Finally
T3009 7-9 , denotes ,
T3010 9-11 PRP denotes it
T3008 12-14 VBZ denotes is
T3011 15-24 JJ denotes important
T3012 25-27 TO denotes to
T3013 28-32 VB denotes note
T3014 33-37 IN denotes that
T3016 38-41 DT denotes the
T3018 42-45 CD denotes two
T3017 46-52 NNS denotes models
T3019 53-56 IN denotes for
T3020 57-60 DT denotes the
T3021 61-69 NN denotes function
T3022 70-72 IN denotes of
T3023 73-76 DT denotes the
T3025 77-82 NN denotes BRCA2
T3027 82-83 HYPH denotes –
T3026 83-88 NN denotes RAD51
T3024 89-100 NN denotes interaction
T3028 101-106 VBN denotes shown
T3029 107-109 IN denotes in
T3030 110-116 NN denotes Figure
T3031 117-118 CD denotes 2
T3015 119-122 VBP denotes are
T3032 123-126 RB denotes not
T3033 127-135 RB denotes mutually
T3034 136-145 JJ denotes exclusive
T3035 145-146 . denotes .
T3036 146-301 sentence denotes BRCA2 could prevent inappropriate RAD51 assembly in the absence of damage and promote functional RAD51 assembly at DNA lesions during the damage response.
T3037 147-152 NN denotes BRCA2
T3039 153-158 MD denotes could
T3038 159-166 VB denotes prevent
T3040 167-180 JJ denotes inappropriate
T3042 181-186 NN denotes RAD51
T3041 187-195 NN denotes assembly
T3043 196-198 IN denotes in
T3044 199-202 DT denotes the
T3045 203-210 NN denotes absence
T3046 211-213 IN denotes of
T3047 214-220 NN denotes damage
T3048 221-224 CC denotes and
T3049 225-232 VB denotes promote
T3050 233-243 JJ denotes functional
T3052 244-249 NN denotes RAD51
T3051 250-258 NN denotes assembly
T3053 259-261 IN denotes at
T3054 262-265 NN denotes DNA
T3055 266-273 NNS denotes lesions
T3056 274-280 IN denotes during
T3057 281-284 DT denotes the
T3059 285-291 NN denotes damage
T3058 292-300 NN denotes response
T3060 300-301 . denotes .
T3061 301-436 sentence denotes Further experiments are clearly required to clarify the functional interactions between BRCA2 and RAD51 during recombinational repair.
T3062 302-309 JJ denotes Further
T3063 310-321 NNS denotes experiments
T3065 322-325 VBP denotes are
T3066 326-333 RB denotes clearly
T3064 334-342 VBN denotes required
T3067 343-345 TO denotes to
T3068 346-353 VB denotes clarify
T3069 354-357 DT denotes the
T3071 358-368 JJ denotes functional
T3070 369-381 NNS denotes interactions
T3072 382-389 IN denotes between
T3073 390-395 NN denotes BRCA2
T3074 396-399 CC denotes and
T3075 400-405 NN denotes RAD51
T3076 406-412 IN denotes during
T3077 413-428 JJ denotes recombinational
T3078 429-435 NN denotes repair
T3079 435-436 . denotes .
T3080 436-564 sentence denotes It should be relatively straightforward to determine whether the role of BRCA2 is limited to transporting RAD51 to the nucleus.
T3081 437-439 PRP denotes It
T3083 440-446 MD denotes should
T3082 447-449 VB denotes be
T3084 450-460 RB denotes relatively
T3085 461-476 JJ denotes straightforward
T3086 477-479 TO denotes to
T3087 480-489 VB denotes determine
T3088 490-497 IN denotes whether
T3090 498-501 DT denotes the
T3091 502-506 NN denotes role
T3092 507-509 IN denotes of
T3093 510-515 NN denotes BRCA2
T3094 516-518 VBZ denotes is
T3089 519-526 VBN denotes limited
T3095 527-529 IN denotes to
T3096 530-542 VBG denotes transporting
T3097 543-548 NN denotes RAD51
T3098 549-551 IN denotes to
T3099 552-555 DT denotes the
T3100 556-563 NN denotes nucleus
T3101 563-564 . denotes .
T3102 564-718 sentence denotes If this were the case, addition of a nuclear localization signal to RAD51 should suppress the RAD51-mediated phenotypes associated with a BRCA2 mutation.
T3103 565-567 IN denotes If
T3105 568-572 DT denotes this
T3104 573-577 VBD denotes were
T3107 578-581 DT denotes the
T3108 582-586 NN denotes case
T3109 586-588 , denotes ,
T3110 588-596 NN denotes addition
T3111 597-599 IN denotes of
T3112 600-601 DT denotes a
T3114 602-609 JJ denotes nuclear
T3115 610-622 NN denotes localization
T3113 623-629 NN denotes signal
T3116 630-632 IN denotes to
T3117 633-638 NN denotes RAD51
T3118 639-645 MD denotes should
T3106 646-654 VB denotes suppress
T3119 655-658 DT denotes the
T3121 659-664 NN denotes RAD51
T3123 664-665 HYPH denotes -
T3122 665-673 VBN denotes mediated
T3120 674-684 NNS denotes phenotypes
T3124 685-695 VBN denotes associated
T3125 696-700 IN denotes with
T3126 701-702 DT denotes a
T3128 703-708 NN denotes BRCA2
T3127 709-717 NN denotes mutation
T3129 717-718 . denotes .
T3130 718-845 sentence denotes However, biochemical experiments are needed to determine whether full-length BRCA2 blocks or promotes RAD51–BRCA2 interaction.
T3131 719-726 RB denotes However
T3133 726-728 , denotes ,
T3134 728-739 JJ denotes biochemical
T3135 740-751 NNS denotes experiments
T3136 752-755 VBP denotes are
T3132 756-762 VBN denotes needed
T3137 763-765 TO denotes to
T3138 766-775 VB denotes determine
T3139 776-783 IN denotes whether
T3141 784-788 JJ denotes full
T3143 788-789 HYPH denotes -
T3142 789-795 NN denotes length
T3144 796-801 NN denotes BRCA2
T3140 802-808 VBZ denotes blocks
T3145 809-811 CC denotes or
T3146 812-820 VBZ denotes promotes
T3147 821-826 NN denotes RAD51
T3149 826-827 HYPH denotes –
T3148 827-832 NN denotes BRCA2
T3150 833-844 NN denotes interaction
T3151 844-845 . denotes .
T3152 845-934 sentence denotes Such experiments could also reveal additional roles for BRCA2 in recombinational repair.
T3153 846-850 JJ denotes Such
T3154 851-862 NNS denotes experiments
T3156 863-868 MD denotes could
T3157 869-873 RB denotes also
T3155 874-880 VB denotes reveal
T3158 881-891 JJ denotes additional
T3159 892-897 NNS denotes roles
T3160 898-901 IN denotes for
T3161 902-907 NN denotes BRCA2
T3162 908-910 IN denotes in
T3163 911-926 JJ denotes recombinational
T3164 927-933 NN denotes repair
T3165 933-934 . denotes .
T3166 934-1081 sentence denotes However, several technical obstacles, including the large size of BRCA2, promise to make biochemical characterization of BRCA2 function difficult.
T3167 935-942 RB denotes However
T3169 942-944 , denotes ,
T3170 944-951 JJ denotes several
T3172 952-961 JJ denotes technical
T3171 962-971 NNS denotes obstacles
T3173 971-973 , denotes ,
T3174 973-982 VBG denotes including
T3175 983-986 DT denotes the
T3177 987-992 JJ denotes large
T3176 993-997 NN denotes size
T3178 998-1000 IN denotes of
T3179 1001-1006 NN denotes BRCA2
T3180 1006-1008 , denotes ,
T3168 1008-1015 VBP denotes promise
T3181 1016-1018 TO denotes to
T3182 1019-1023 VB denotes make
T3183 1024-1035 JJ denotes biochemical
T3184 1036-1052 NN denotes characterization
T3186 1053-1055 IN denotes of
T3187 1056-1061 NN denotes BRCA2
T3188 1062-1070 NN denotes function
T3185 1071-1080 JJ denotes difficult
T3189 1080-1081 . denotes .
R2062 T3007 T3008 advmod Finally,is
R2064 T3009 T3008 punct ", ",is
R2065 T3011 T3008 acomp important,is
R2066 T3012 T3013 aux to,note
R2067 T3010 T3008 nsubj it,is
R2068 T3014 T3015 mark that,are
R2069 T3015 T3013 ccomp are,note
R2070 T3013 T3008 xcomp note,is
R2071 T3017 T3015 nsubj models,are
R2072 T3018 T3017 nummod two,models
R2073 T3016 T3017 det the,models
R2074 T3020 T3021 det the,function
R2075 T3021 T3019 pobj function,for
R2076 T3022 T3021 prep of,function
R2077 T3019 T3017 prep for,models
R2078 T3024 T3022 pobj interaction,of
R2079 T3025 T3026 compound BRCA2,RAD51
R2080 T3023 T3024 det the,interaction
R2081 T3026 T3024 compound RAD51,interaction
R2082 T3028 T3017 acl shown,models
R2083 T3029 T3028 prep in,shown
R2084 T3027 T3026 punct –,RAD51
R2085 T3031 T3030 nummod 2,Figure
R2086 T3030 T3029 pobj Figure,in
R2087 T3033 T3034 advmod mutually,exclusive
R2088 T3034 T3015 acomp exclusive,are
R2089 T3032 T3015 neg not,are
R2090 T3039 T3038 aux could,prevent
R2091 T3035 T3008 punct .,is
R2092 T3041 T3038 dobj assembly,prevent
R2093 T3037 T3038 nsubj BRCA2,prevent
R2094 T3042 T3041 compound RAD51,assembly
R2095 T3040 T3041 amod inappropriate,assembly
R2096 T3044 T3045 det the,absence
R2097 T3043 T3038 prep in,prevent
R2098 T3046 T3045 prep of,absence
R2099 T3045 T3043 pobj absence,in
R2100 T3048 T3038 cc and,prevent
R2101 T3049 T3038 conj promote,prevent
R2102 T3047 T3046 pobj damage,of
R2103 T3051 T3049 dobj assembly,promote
R2104 T3052 T3051 compound RAD51,assembly
R2105 T3050 T3051 amod functional,assembly
R2106 T3054 T3055 compound DNA,lesions
R2107 T3055 T3053 pobj lesions,at
R2108 T3053 T3051 prep at,assembly
R2109 T3057 T3058 det the,response
R2110 T3056 T3049 prep during,promote
R2111 T3059 T3058 compound damage,response
R2112 T3060 T3038 punct .,prevent
R2113 T3058 T3056 pobj response,during
R2114 T3062 T3063 amod Further,experiments
R2115 T3065 T3064 auxpass are,required
R2116 T3066 T3064 advmod clearly,required
R2117 T3063 T3064 nsubjpass experiments,required
R2118 T3068 T3064 advcl clarify,required
R2119 T3069 T3070 det the,interactions
R2120 T3067 T3068 aux to,clarify
R2121 T3071 T3070 amod functional,interactions
R2122 T3070 T3068 dobj interactions,clarify
R2123 T3073 T3072 pobj BRCA2,between
R2124 T3074 T3073 cc and,BRCA2
R2125 T3072 T3070 prep between,interactions
R2126 T3076 T3068 prep during,clarify
R2127 T3077 T3078 amod recombinational,repair
R2128 T3075 T3073 conj RAD51,BRCA2
R2129 T3079 T3064 punct .,required
R2130 T3078 T3076 pobj repair,during
R2131 T3083 T3082 aux should,be
R2132 T3084 T3085 advmod relatively,straightforward
R2133 T3085 T3082 acomp straightforward,be
R2134 T3081 T3082 nsubj It,be
R2135 T3087 T3082 xcomp determine,be
R2136 T3089 T3087 ccomp limited,determine
R2137 T3086 T3087 aux to,determine
R2138 T3090 T3091 det the,role
R2139 T3088 T3089 mark whether,limited
R2140 T3092 T3091 prep of,role
R2141 T3091 T3089 nsubjpass role,limited
R2142 T3094 T3089 auxpass is,limited
R2143 T3095 T3089 prep to,limited
R2144 T3093 T3092 pobj BRCA2,of
R2145 T3097 T3096 dobj RAD51,transporting
R2146 T3096 T3095 pcomp transporting,to
R2147 T3099 T3100 det the,nucleus
R2148 T3100 T3098 pobj nucleus,to
R2149 T3098 T3096 prep to,transporting
R2150 T3103 T3104 mark If,were
R2151 T3101 T3082 punct .,be
R2152 T3105 T3104 nsubj this,were
R2153 T3108 T3104 attr case,were
R2154 T3104 T3106 advcl were,suppress
R2155 T3109 T3106 punct ", ",suppress
R2156 T3107 T3108 det the,case
R2157 T3111 T3110 prep of,addition
R2158 T3112 T3113 det a,signal
R2159 T3113 T3111 pobj signal,of
R2160 T3110 T3106 nsubj addition,suppress
R2161 T3115 T3113 compound localization,signal
R2162 T3116 T3110 prep to,addition
R2163 T3114 T3113 amod nuclear,signal
R2164 T3118 T3106 aux should,suppress
R2165 T3119 T3120 det the,phenotypes
R2166 T3117 T3116 pobj RAD51,to
R2167 T3121 T3122 npadvmod RAD51,mediated
R2168 T3122 T3120 amod mediated,phenotypes
R2169 T3120 T3106 dobj phenotypes,suppress
R2170 T3124 T3120 acl associated,phenotypes
R2171 T3125 T3124 prep with,associated
R2172 T3123 T3122 punct -,mediated
R2173 T3127 T3125 pobj mutation,with
R2174 T3128 T3127 compound BRCA2,mutation
R2175 T3126 T3127 det a,mutation
R2176 T3133 T3132 punct ", ",needed
R2177 T3129 T3106 punct .,suppress
R2178 T3131 T3132 advmod However,needed
R2179 T3135 T3132 nsubjpass experiments,needed
R2180 T3136 T3132 auxpass are,needed
R2181 T3134 T3135 amod biochemical,experiments
R2182 T3138 T3132 advcl determine,needed
R2183 T3137 T3138 aux to,determine
R2184 T3140 T3138 ccomp blocks,determine
R2185 T3141 T3142 amod full,length
R2186 T3139 T3140 mark whether,blocks
R2187 T3143 T3142 punct -,length
R2188 T3144 T3140 nsubj BRCA2,blocks
R2189 T3142 T3144 compound length,BRCA2
R2190 T3146 T3140 conj promotes,blocks
R2191 T3147 T3148 compound RAD51,BRCA2
R2192 T3145 T3140 cc or,blocks
R2193 T3149 T3148 punct –,BRCA2
R2194 T3148 T3150 compound BRCA2,interaction
R2195 T3151 T3132 punct .,needed
R2196 T3154 T3155 nsubj experiments,reveal
R2197 T3150 T3146 dobj interaction,promotes
R2198 T3153 T3154 amod Such,experiments
R2199 T3156 T3155 aux could,reveal
R2200 T3158 T3159 amod additional,roles
R2201 T3159 T3155 dobj roles,reveal
R2202 T3157 T3155 advmod also,reveal
R2203 T3161 T3160 pobj BRCA2,for
R2204 T3162 T3159 prep in,roles
R2205 T3160 T3159 prep for,roles
R2206 T3164 T3162 pobj repair,in
R2207 T3163 T3164 amod recombinational,repair
R2208 T3169 T3168 punct ", ",promise
R2209 T3165 T3155 punct .,reveal
R2210 T3167 T3168 advmod However,promise
R2211 T3171 T3168 nsubj obstacles,promise
R2212 T3172 T3171 amod technical,obstacles
R2213 T3170 T3171 amod several,obstacles
R2214 T3174 T3171 prep including,obstacles
R2215 T3175 T3176 det the,size
R2216 T3173 T3171 punct ", ",obstacles
R2217 T3177 T3176 amod large,size
R2218 T3178 T3176 prep of,size
R2219 T3176 T3174 pobj size,including
R2220 T3180 T3168 punct ", ",promise
R2221 T3181 T3182 aux to,make
R2222 T3182 T3168 xcomp make,promise
R2223 T3179 T3178 pobj BRCA2,of
R2224 T3184 T3185 nsubj characterization,difficult
R2225 T3185 T3182 ccomp difficult,make
R2226 T3183 T3184 amod biochemical,characterization
R2227 T3187 T3188 compound BRCA2,function
R2228 T3186 T3184 prep of,characterization
R2229 T3189 T3168 punct .,promise
R2231 T3188 T3186 pobj function,of