craft-sa-dev Home  

PMC:138691 / 11250-12442 JSONTXT 4 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T2861 0-1192 sentence denotes Figure 2 Potential roles of BRCA2 in promoting assembly of Rad51 at sites of DNA damage. Chromosomal DNA is shown as pairs of straight lines, Rad51 as open circles, and BRCA2 as grey bars. (a) Prevention of nonproductive DNA interactions. BRCA2–Rad51 interaction is proposed to suppress RAD51–BRCA2 interactions until DNA damage is present. When damage occurs, Rad51 is recruited to damaged sites where is polymerizes into nucleoprotein filaments. In this model, BRCA2 is not required for assembly of functional complexes at damaged sites, only to prevent a substantial fraction of Rad51 from being sequestered in a nonfunctional form. In a BRCA2-defective cell, mutant Rad51 becomes associated with DNA at random sites and is therefore not readily recruited to sites of damage. (b) Positive regulation. BRCA2 is proposed to be required for Rad51 to assemble into functional recombinational repair complexes at sites of damage. In BRCA-defective cells, Rad51 fails to associate with sites of damage due to lack of an assembly factor. Yet another potential role for BRCA2 in promoting RAD51-dependent recombinational repair is a positive role in assembly of RAD51 at damaged sites (Fig. 2b).
T2862 1036-1039 RB denotes Yet
T2864 1040-1047 DT denotes another
T2865 1048-1057 JJ denotes potential
T2863 1058-1062 NN denotes role
T2867 1063-1066 IN denotes for
T2868 1067-1072 NN denotes BRCA2
T2869 1073-1075 IN denotes in
T2870 1076-1085 VBG denotes promoting
T2871 1086-1091 NN denotes RAD51
T2873 1091-1092 HYPH denotes -
T2872 1092-1101 JJ denotes dependent
T2875 1102-1117 JJ denotes recombinational
T2874 1118-1124 NN denotes repair
T2866 1125-1127 VBZ denotes is
T2876 1128-1129 DT denotes a
T2878 1130-1138 JJ denotes positive
T2877 1139-1143 NN denotes role
T2879 1144-1146 IN denotes in
T2880 1147-1155 NN denotes assembly
T2881 1156-1158 IN denotes of
T2882 1159-1164 NN denotes RAD51
T2883 1165-1167 IN denotes at
T2884 1168-1175 VBN denotes damaged
T2885 1176-1181 NNS denotes sites
T2886 1182-1183 -LRB- denotes (
T2888 1183-1187 NN denotes Fig.
T2887 1188-1190 NN denotes 2b
T2889 1190-1191 -RRB- denotes )
T2890 1191-1192 . denotes .
R1927 T2862 T2863 advmod Yet,role
R1929 T2864 T2863 det another,role
R1930 T2867 T2863 prep for,role
R1931 T2863 T2866 nsubj role,is
R1932 T2865 T2863 amod potential,role
R1933 T2869 T2863 prep in,role
R1934 T2870 T2869 pcomp promoting,in
R1935 T2868 T2867 pobj BRCA2,for
R1936 T2872 T2874 amod dependent,repair
R1937 T2873 T2872 punct -,dependent
R1938 T2871 T2872 npadvmod RAD51,dependent
R1939 T2875 T2874 amod recombinational,repair
R1940 T2876 T2877 det a,role
R1941 T2874 T2870 dobj repair,promoting
R1942 T2878 T2877 amod positive,role
R1943 T2877 T2866 attr role,is
R1944 T2880 T2879 pobj assembly,in
R1945 T2881 T2880 prep of,assembly
R1946 T2879 T2877 prep in,role
R1947 T2883 T2880 prep at,assembly
R1948 T2884 T2885 amod damaged,sites
R1949 T2882 T2881 pobj RAD51,of
R1950 T2886 T2887 punct (,2b
R1951 T2885 T2883 pobj sites,at
R1952 T2888 T2887 compound Fig.,2b
R1953 T2889 T2887 punct ),2b
R1954 T2887 T2866 parataxis 2b,is
R1956 T2890 T2866 punct .,is