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PMC:1382200 / 24988-26034 JSONTXT 4 Projects

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Id Subject Object Predicate Lexical cue
T14441 0-3 DT denotes The
T14443 4-15 JJ denotes mechanistic
T14442 16-23 NNS denotes reasons
T14445 24-27 IN denotes for
T14446 28-37 NN denotes lethality
T14447 38-40 IN denotes in
T14448 41-44 DT denotes the
T14449 45-52 NN denotes absence
T14450 53-55 IN denotes of
T14451 56-57 NN denotes m
T14453 57-58 HYPH denotes -
T14452 58-65 NN denotes calpain
T14444 66-69 VBP denotes are
T14454 70-75 RB denotes still
T14455 76-83 JJ denotes unclear
T14456 83-84 . denotes .
T14457 84-304 sentence denotes There have been several reports of m-calpain involvement in cell proliferation in certain circumstances, including reports of its involvement in chromosome segregation during mitosis [44] as well as during meiosis [45].
T14458 85-90 EX denotes There
T14460 91-95 VBP denotes have
T14459 96-100 VBN denotes been
T14461 101-108 JJ denotes several
T14462 109-116 NNS denotes reports
T14463 117-119 IN denotes of
T14464 120-121 NN denotes m
T14466 121-122 HYPH denotes -
T14465 122-129 NN denotes calpain
T14467 130-141 NN denotes involvement
T14468 142-144 IN denotes in
T14469 145-149 NN denotes cell
T14470 150-163 NN denotes proliferation
T14471 164-166 IN denotes in
T14472 167-174 JJ denotes certain
T14473 175-188 NNS denotes circumstances
T14474 188-190 , denotes ,
T14475 190-199 VBG denotes including
T14476 200-207 NNS denotes reports
T14477 208-210 IN denotes of
T14478 211-214 PRP$ denotes its
T14479 215-226 NN denotes involvement
T14480 227-229 IN denotes in
T14481 230-240 NN denotes chromosome
T14482 241-252 NN denotes segregation
T14483 253-259 IN denotes during
T14484 260-267 NN denotes mitosis
T14485 268-269 -LRB- denotes [
T14486 269-271 CD denotes 44
T14487 271-272 -RRB- denotes ]
T14488 273-275 RB denotes as
T14490 276-280 RB denotes well
T14489 281-283 IN denotes as
T14491 284-290 IN denotes during
T14492 291-298 NN denotes meiosis
T14493 299-300 -LRB- denotes [
T14494 300-302 CD denotes 45
T14495 302-303 -RRB- denotes ]
T14496 303-304 . denotes .
T14497 304-408 sentence denotes Defects in migration, reported in Capn4-/- cells [9], could contribute to failed embryonic development.
T14498 305-312 NNS denotes Defects
T14500 313-315 IN denotes in
T14501 316-325 NN denotes migration
T14502 325-327 , denotes ,
T14503 327-335 VBN denotes reported
T14504 336-338 IN denotes in
T14505 339-344 NN denotes Capn4
T14507 344-345 SYM denotes -
T14508 345-346 HYPH denotes /
T14509 346-347 SYM denotes -
T14506 348-353 NNS denotes cells
T14510 354-355 -LRB- denotes [
T14511 355-356 CD denotes 9
T14512 356-357 -RRB- denotes ]
T14513 357-359 , denotes ,
T14514 359-364 MD denotes could
T14499 365-375 VB denotes contribute
T14515 376-378 IN denotes to
T14516 379-385 VBN denotes failed
T14518 386-395 JJ denotes embryonic
T14517 396-407 NN denotes development
T14519 407-408 . denotes .
T14520 408-657 sentence denotes The association between calpain and cell viability has been noted in Capn4-/- MEFs and other cell lines, although the reported work frequently did not distinguish between μ- and m-calpain, and did not show that calpain was strictly essential [5,6].
T14521 409-412 DT denotes The
T14522 413-424 NN denotes association
T14524 425-432 IN denotes between
T14525 433-440 NN denotes calpain
T14526 441-444 CC denotes and
T14527 445-449 NN denotes cell
T14528 450-459 NN denotes viability
T14529 460-463 VBZ denotes has
T14530 464-468 VBN denotes been
T14523 469-474 VBN denotes noted
T14531 475-477 IN denotes in
T14532 478-483 NN denotes Capn4
T14534 483-484 SYM denotes -
T14535 484-485 HYPH denotes /
T14536 485-486 SYM denotes -
T14533 487-491 NNS denotes MEFs
T14537 492-495 CC denotes and
T14538 496-501 JJ denotes other
T14540 502-506 NN denotes cell
T14539 507-512 NNS denotes lines
T14541 512-514 , denotes ,
T14542 514-522 IN denotes although
T14544 523-526 DT denotes the
T14546 527-535 VBN denotes reported
T14545 536-540 NN denotes work
T14547 541-551 RB denotes frequently
T14548 552-555 VBD denotes did
T14549 556-559 RB denotes not
T14543 560-571 VB denotes distinguish
T14550 572-579 IN denotes between
T14551 580-581 NN denotes μ
T14553 581-582 HYPH denotes -
T14554 583-586 CC denotes and
T14555 587-588 NN denotes m
T14556 588-589 HYPH denotes -
T14552 589-596 NN denotes calpain
T14557 596-598 , denotes ,
T14558 598-601 CC denotes and
T14559 602-605 VBD denotes did
T14561 606-609 RB denotes not
T14560 610-614 VB denotes show
T14562 615-619 IN denotes that
T14564 620-627 NN denotes calpain
T14563 628-631 VBD denotes was
T14565 632-640 RB denotes strictly
T14566 641-650 JJ denotes essential
T14567 651-652 -LRB- denotes [
T14569 652-653 CD denotes 5
T14570 653-654 , denotes ,
T14568 654-655 CD denotes 6
T14571 655-656 -RRB- denotes ]
T14572 656-657 . denotes .
T14573 657-786 sentence denotes In both CHO cells and Capn4-/- MEFs, calpain was shown to influence cell proliferation, but only at very low cell densities [5].
T14574 658-660 IN denotes In
T14576 661-665 CC denotes both
T14578 666-669 NN denotes CHO
T14577 670-675 NNS denotes cells
T14579 676-679 CC denotes and
T14580 680-685 NN denotes Capn4
T14582 685-686 SYM denotes -
T14583 686-687 HYPH denotes /
T14584 687-688 SYM denotes -
T14581 689-693 NNS denotes MEFs
T14585 693-695 , denotes ,
T14586 695-702 NN denotes calpain
T14587 703-706 VBD denotes was
T14575 707-712 VBN denotes shown
T14588 713-715 TO denotes to
T14589 716-725 VB denotes influence
T14590 726-730 NN denotes cell
T14591 731-744 NN denotes proliferation
T14592 744-746 , denotes ,
T14593 746-749 CC denotes but
T14595 750-754 RB denotes only
T14594 755-757 IN denotes at
T14596 758-762 RB denotes very
T14597 763-766 JJ denotes low
T14599 767-771 NN denotes cell
T14598 772-781 NNS denotes densities
T14600 782-783 -LRB- denotes [
T14601 783-784 CD denotes 5
T14602 784-785 -RRB- denotes ]
T14603 785-786 . denotes .
T14604 786-880 sentence denotes Calpain has also been associated with progression through the G1 stage of the cell cycle [6].
T14605 787-794 NN denotes Calpain
T14607 795-798 VBZ denotes has
T14608 799-803 RB denotes also
T14609 804-808 VBN denotes been
T14606 809-819 VBN denotes associated
T14610 820-824 IN denotes with
T14611 825-836 NN denotes progression
T14612 837-844 IN denotes through
T14613 845-848 DT denotes the
T14615 849-851 NN denotes G1
T14614 852-857 NN denotes stage
T14616 858-860 IN denotes of
T14617 861-864 DT denotes the
T14619 865-869 NN denotes cell
T14618 870-875 NN denotes cycle
T14620 876-877 -LRB- denotes [
T14621 877-878 CD denotes 6
T14622 878-879 -RRB- denotes ]
T14623 879-880 . denotes .
T14624 880-1046 sentence denotes Furthermore, some of the proteins known to be involved in cell cycle progression, such as p53, p107, cyclin D1, and p27kip1 are reputed to be calpain substrates [3].
T14625 881-892 RB denotes Furthermore
T14627 892-894 , denotes ,
T14628 894-898 DT denotes some
T14629 899-901 IN denotes of
T14630 902-905 DT denotes the
T14631 906-914 NN denotes proteins
T14632 915-920 VBN denotes known
T14633 921-923 TO denotes to
T14635 924-926 VB denotes be
T14634 927-935 VBN denotes involved
T14636 936-938 IN denotes in
T14637 939-943 NN denotes cell
T14638 944-949 NN denotes cycle
T14639 950-961 NN denotes progression
T14640 961-963 , denotes ,
T14641 963-967 JJ denotes such
T14642 968-970 IN denotes as
T14643 971-974 NN denotes p53
T14644 974-976 , denotes ,
T14645 976-980 NN denotes p107
T14646 980-982 , denotes ,
T14647 982-988 NN denotes cyclin
T14648 989-991 NN denotes D1
T14649 991-993 , denotes ,
T14650 993-996 CC denotes and
T14651 997-1004 NN denotes p27kip1
T14652 1005-1008 VBP denotes are
T14626 1009-1016 VBN denotes reputed
T14653 1017-1019 TO denotes to
T14654 1020-1022 VB denotes be
T14655 1023-1030 NN denotes calpain
T14656 1031-1041 NNS denotes substrates
T14657 1042-1043 -LRB- denotes [
T14658 1043-1044 CD denotes 3
T14659 1044-1045 -RRB- denotes ]
T14660 1045-1046 . denotes .
R3829 T14465 T14467 compound calpain,involvement
R3831 T14466 T14465 punct -,calpain
R3832 T14467 T14463 pobj involvement,of
R3833 T14468 T14467 prep in,involvement
R3835 T14469 T14470 compound cell,proliferation
R3836 T14470 T14468 pobj proliferation,in
R3838 T14471 T14467 prep in,involvement
R3839 T14472 T14473 amod certain,circumstances
R3840 T14473 T14471 pobj circumstances,in
R3841 T14474 T14462 punct ", ",reports
R3843 T14475 T14462 prep including,reports
R3844 T14476 T14475 pobj reports,including
R3845 T14477 T14476 prep of,reports
R3847 T14478 T14479 poss its,involvement
R3848 T14479 T14477 pobj involvement,of
R3849 T14480 T14479 prep in,involvement
R3851 T14481 T14482 compound chromosome,segregation
R3852 T14482 T14480 pobj segregation,in
R3854 T14483 T14482 prep during,segregation
R3855 T14484 T14483 pobj mitosis,during
R3856 T14485 T14486 punct [,44
R3858 T14486 T14484 parataxis 44,mitosis
R3859 T14487 T14486 punct ],44
R3860 T14488 T14489 advmod as,as
R3861 T14489 T14483 cc as,during
R3862 T14490 T14489 advmod well,as
R3863 T14491 T14483 conj during,during
R3864 T14492 T14491 pobj meiosis,during
R3866 T14493 T14494 punct [,45
R3867 T14494 T14492 parataxis 45,meiosis
R3868 T14495 T14494 punct ],45
R3870 T14496 T14459 punct .,been
R3872 T14498 T14499 nsubj Defects,contribute
R3873 T14500 T14498 prep in,Defects
R3874 T14501 T14500 pobj migration,in
R3876 T14502 T14498 punct ", ",Defects
R3877 T14503 T14498 acl reported,Defects
R3878 T14504 T14503 prep in,reported
R3880 T14505 T14506 nmod Capn4,cells
R3881 T14506 T14504 pobj cells,in
R3882 T14507 T14505 punct -,Capn4
R3884 T14508 T14505 punct /,Capn4
R3885 T14509 T14505 punct -,Capn4
R3887 T14510 T14511 punct [,9
R3888 T14511 T14503 parataxis 9,reported
R3889 T14512 T14511 punct ],9
R3891 T14513 T14499 punct ", ",contribute
R3892 T14514 T14499 aux could,contribute
R3893 T14515 T14499 prep to,contribute
R3895 T14516 T14517 amod failed,development
R3897 T14517 T14515 pobj development,to
R3898 T14518 T14517 amod embryonic,development
R3899 T14519 T14499 punct .,contribute
R3901 T14521 T14522 det The,association
R3902 T14522 T14523 nsubjpass association,noted
R3904 T14524 T14522 prep between,association
R3906 T14525 T14524 pobj calpain,between
R3907 T14526 T14525 cc and,calpain
R3909 T14527 T14528 compound cell,viability
R3910 T14528 T14525 conj viability,calpain
R3911 T14529 T14523 aux has,noted
R3913 T14530 T14523 auxpass been,noted
R3914 T14531 T14523 prep in,noted
R3915 T14532 T14533 nmod Capn4,MEFs
R3916 T14533 T14531 pobj MEFs,in
R3917 T14534 T14532 punct -,Capn4
R3918 T14535 T14532 punct /,Capn4
R3919 T14536 T14532 punct -,Capn4
R3921 T14537 T14533 cc and,MEFs
R3922 T14538 T14539 amod other,lines
R3925 T14539 T14533 conj lines,MEFs
R3926 T14540 T14539 compound cell,lines
R3927 T14541 T14523 punct ", ",noted
R3929 T14542 T14543 mark although,distinguish
R3930 T14543 T14523 advcl distinguish,noted
R3932 T14544 T14545 det the,work
R3933 T14545 T14543 nsubj work,distinguish
R3935 T14546 T14545 amod reported,work
R3936 T14547 T14543 advmod frequently,distinguish
R3938 T14548 T14543 aux did,distinguish
R3939 T14549 T14543 neg not,distinguish
R3940 T14550 T14543 prep between,distinguish
R3942 T14551 T14552 nmod μ,calpain
R3943 T14552 T14550 pobj calpain,between
R3945 T14553 T14551 punct -,μ
R3946 T14554 T14551 cc and,μ
R3948 T14555 T14551 conj m,μ
R3949 T14556 T14552 punct -,calpain
R3950 T14557 T14543 punct ", ",distinguish
R3952 T14558 T14543 cc and,distinguish
R3953 T14559 T14560 aux did,show
R3955 T14560 T14543 conj show,distinguish
R3956 T14561 T14560 neg not,show
R3957 T14562 T14563 mark that,was
R3959 T14563 T14560 ccomp was,show
R3960 T14564 T14563 nsubj calpain,was
R3961 T14565 T14566 advmod strictly,essential
R3963 T14566 T14563 acomp essential,was
R3964 T14567 T14568 punct [,6
R3965 T14568 T14560 parataxis 6,show
R3966 T14569 T14568 nummod 5,6
R3969 T14570 T14568 punct ",",6
R3970 T14571 T14568 punct ],6
R3971 T14572 T14523 punct .,noted
R3973 T14574 T14575 prep In,shown
R3975 T14576 T14577 preconj both,cells
R3976 T14577 T14574 pobj cells,In
R3978 T14578 T14577 compound CHO,cells
R3979 T14579 T14577 cc and,cells
R3980 T14580 T14581 nmod Capn4,MEFs
R3982 T14581 T14577 conj MEFs,cells
R3983 T14582 T14580 punct -,Capn4
R3984 T14583 T14580 punct /,Capn4
R3986 T14584 T14580 punct -,Capn4
R3987 T14585 T14575 punct ", ",shown
R3989 T14586 T14575 nsubjpass calpain,shown
R3990 T14587 T14575 auxpass was,shown
R3991 T14588 T14589 aux to,influence
R3993 T14589 T14575 xcomp influence,shown
R3994 T14590 T14591 compound cell,proliferation
R3995 T14591 T14589 dobj proliferation,influence
R3997 T14592 T14589 punct ", ",influence
R3998 T14593 T14594 cc but,at
R3999 T14594 T14589 prep at,influence
R4001 T14595 T14594 advmod only,at
R4002 T14596 T14597 advmod very,low
R4003 T14597 T14598 amod low,densities
R4005 T14598 T14594 pobj densities,at
R4006 T14599 T14598 compound cell,densities
R4007 T14600 T14601 punct [,5
R4009 T14601 T14589 parataxis 5,influence
R4010 T14602 T14601 punct ],5
R4012 T14603 T14575 punct .,shown
R4013 T14605 T14606 nsubjpass Calpain,associated
R4015 T14607 T14606 aux has,associated
R4017 T14608 T14606 advmod also,associated
R4018 T14609 T14606 auxpass been,associated
R4019 T14610 T14606 prep with,associated
R4020 T14611 T14610 pobj progression,with
R4021 T14612 T14611 prep through,progression
R4023 T14613 T14614 det the,stage
R4024 T14614 T14612 pobj stage,through
R4025 T14615 T14614 compound G1,stage
R4027 T14616 T14614 prep of,stage
R4028 T14617 T14618 det the,cycle
R4030 T14618 T14616 pobj cycle,of
R4031 T14619 T14618 compound cell,cycle
R4032 T14620 T14621 punct [,6
R4034 T14621 T14606 parataxis 6,associated
R4035 T14622 T14621 punct ],6
R4036 T14623 T14606 punct .,associated
R4039 T14625 T14626 advmod Furthermore,reputed
R4041 T14627 T14626 punct ", ",reputed
R4043 T14628 T14626 nsubjpass some,reputed
R4044 T14629 T14628 prep of,some
R4045 T14630 T14631 det the,proteins
R4047 T14631 T14629 pobj proteins,of
R4048 T14632 T14631 acl known,proteins
R4050 T14633 T14634 aux to,involved
R4051 T14634 T14632 xcomp involved,known
R4052 T14635 T14634 auxpass be,involved
R4054 T14636 T14634 prep in,involved
R4055 T14637 T14638 compound cell,cycle
R4056 T14638 T14639 compound cycle,progression
R4057 T14441 T14442 det The,reasons
R4058 T14639 T14636 pobj progression,in
R4059 T14640 T14631 punct ", ",proteins
R4060 T14641 T14642 amod such,as
R4061 T14642 T14631 prep as,proteins
R4062 T14442 T14444 nsubj reasons,are
R4063 T14643 T14642 pobj p53,as
R4064 T14644 T14643 punct ", ",p53
R4065 T14645 T14643 conj p107,p53
R4066 T14443 T14442 amod mechanistic,reasons
R4067 T14646 T14645 punct ", ",p107
R4068 T14647 T14648 compound cyclin,D1
R4069 T14445 T14442 prep for,reasons
R4070 T14648 T14645 conj D1,p107
R4071 T14649 T14648 punct ", ",D1
R4072 T14650 T14648 cc and,D1
R4073 T14651 T14648 conj p27kip1,D1
R4074 T14652 T14626 auxpass are,reputed
R4075 T14653 T14654 aux to,be
R4076 T14446 T14445 pobj lethality,for
R4077 T14654 T14626 xcomp be,reputed
R4078 T14655 T14656 compound calpain,substrates
R4079 T14656 T14654 attr substrates,be
R4080 T14447 T14442 prep in,reasons
R4081 T14657 T14658 punct [,3
R4082 T14658 T14654 parataxis 3,be
R4083 T14659 T14658 punct ],3
R4084 T14448 T14449 det the,absence
R4085 T14660 T14626 punct .,reputed
R4087 T14449 T14447 pobj absence,in
R4089 T14450 T14449 prep of,absence
R4093 T14451 T14452 compound m,calpain
R4097 T14452 T14450 pobj calpain,of
R4101 T14453 T14452 punct -,calpain
R4104 T14454 T14444 advmod still,are
R4105 T14455 T14444 acomp unclear,are
R4107 T14456 T14444 punct .,are
R4111 T14458 T14459 expl There,been
R4115 T14460 T14459 aux have,been
R4120 T14461 T14462 amod several,reports
R4126 T14462 T14459 attr reports,been
R4130 T14463 T14462 prep of,reports
R4134 T14464 T14465 compound m,calpain