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PMC:1382200 / 1656-2929 JSONTXT 4 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T3244 0-3 DT denotes The
T3246 4-7 CD denotes two
T3247 8-18 JJ denotes ubiquitous
T3248 19-22 NN denotes Ca2
T3250 22-23 SYM denotes +
T3251 23-24 HYPH denotes -
T3249 24-33 JJ denotes dependent
T3252 33-35 , denotes ,
T3253 35-43 NN denotes cysteine
T3245 44-53 NNS denotes proteases
T3255 54-59 VBN denotes known
T3256 60-62 IN denotes as
T3257 63-64 NN denotes μ
T3259 64-65 HYPH denotes -
T3258 65-72 NN denotes calpain
T3260 73-74 -LRB- denotes (
T3261 74-81 NN denotes calpain
T3262 81-82 HYPH denotes -
T3263 82-83 CD denotes 1
T3264 83-84 -RRB- denotes )
T3265 85-88 CC denotes and
T3266 89-90 NN denotes m
T3268 90-91 HYPH denotes -
T3267 91-98 NN denotes calpain
T3269 99-100 -LRB- denotes (
T3270 100-106 NN denotes capain
T3271 106-107 HYPH denotes -
T3272 107-108 CD denotes 2
T3273 108-109 -RRB- denotes )
T3274 109-111 , denotes ,
T3254 111-114 VBP denotes are
T3275 115-118 DT denotes the
T3277 119-127 NN denotes founding
T3276 128-135 NNS denotes members
T3278 136-138 IN denotes of
T3279 139-140 DT denotes a
T3281 141-145 NN denotes gene
T3280 146-152 NN denotes family
T3282 153-163 VBG denotes comprising
T3283 164-166 CD denotes 13
T3284 167-172 NNS denotes genes
T3285 173-175 IN denotes in
T3286 176-183 NNS denotes mammals
T3287 184-185 -LRB- denotes [
T3288 185-186 CD denotes 1
T3289 186-187 SYM denotes -
T3290 187-188 CD denotes 3
T3291 188-189 -RRB- denotes ]
T3292 189-190 . denotes .
T3293 190-423 sentence denotes Both are heterodimeric enzymes consisting of distinct 80 kDa catalytic subunits, encoded by the Capn1 (μ-80 k) and Capn2 (m-80 k) genes, respectively, that associate with a common 28 kDa regulatory subunit encoded by the Capn4 gene.
T3294 191-195 DT denotes Both
T3295 196-199 VBP denotes are
T3296 200-213 JJ denotes heterodimeric
T3297 214-221 NNS denotes enzymes
T3298 222-232 VBG denotes consisting
T3299 233-235 IN denotes of
T3300 236-244 JJ denotes distinct
T3302 245-247 CD denotes 80
T3303 248-251 NN denotes kDa
T3304 252-261 JJ denotes catalytic
T3301 262-270 NNS denotes subunits
T3305 270-272 , denotes ,
T3306 272-279 VBN denotes encoded
T3307 280-282 IN denotes by
T3308 283-286 DT denotes the
T3310 287-292 NN denotes Capn1
T3311 293-294 -LRB- denotes (
T3313 294-295 NN denotes μ
T3314 295-296 HYPH denotes -
T3315 296-298 CD denotes 80
T3312 299-300 NN denotes k
T3316 300-301 -RRB- denotes )
T3317 302-305 CC denotes and
T3318 306-311 NN denotes Capn2
T3319 312-313 -LRB- denotes (
T3321 313-314 NN denotes m
T3322 314-315 HYPH denotes -
T3323 315-317 CD denotes 80
T3320 318-319 NN denotes k
T3324 319-320 -RRB- denotes )
T3309 321-326 NNS denotes genes
T3325 326-328 , denotes ,
T3326 328-340 RB denotes respectively
T3327 340-342 , denotes ,
T3328 342-346 WDT denotes that
T3329 347-356 VBP denotes associate
T3330 357-361 IN denotes with
T3331 362-363 DT denotes a
T3333 364-370 JJ denotes common
T3334 371-373 CD denotes 28
T3335 374-377 NN denotes kDa
T3336 378-388 JJ denotes regulatory
T3332 389-396 NN denotes subunit
T3337 397-404 VBN denotes encoded
T3338 405-407 IN denotes by
T3339 408-411 DT denotes the
T3341 412-417 NN denotes Capn4
T3340 418-422 NN denotes gene
T3342 422-423 . denotes .
T3343 423-593 sentence denotes The μ-80 k and m-80 k subunits share 62% amino acid sequence identity, and are very similar in terms of structure, protein chemistry, and in vitro substrate specificity.
T3344 424-427 DT denotes The
T3346 428-429 NN denotes μ
T3348 429-430 HYPH denotes -
T3349 430-432 CD denotes 80
T3347 433-434 NN denotes k
T3350 435-438 CC denotes and
T3351 439-440 NN denotes m
T3353 440-441 HYPH denotes -
T3354 441-443 CD denotes 80
T3352 444-445 NN denotes k
T3345 446-454 NNS denotes subunits
T3355 455-460 VBP denotes share
T3356 461-463 CD denotes 62
T3357 463-464 NN denotes %
T3359 465-470 NN denotes amino
T3360 471-475 NN denotes acid
T3361 476-484 NN denotes sequence
T3358 485-493 NN denotes identity
T3362 493-495 , denotes ,
T3363 495-498 CC denotes and
T3364 499-502 VBP denotes are
T3365 503-507 RB denotes very
T3366 508-515 JJ denotes similar
T3367 516-518 IN denotes in
T3368 519-524 NNS denotes terms
T3369 525-527 IN denotes of
T3370 528-537 NN denotes structure
T3371 537-539 , denotes ,
T3372 539-546 NN denotes protein
T3373 547-556 NN denotes chemistry
T3374 556-558 , denotes ,
T3375 558-561 CC denotes and
T3376 562-564 FW denotes in
T3377 565-570 FW denotes vitro
T3379 571-580 NN denotes substrate
T3378 581-592 NN denotes specificity
T3380 592-593 . denotes .
T3381 593-763 sentence denotes Despite these similarities, the differential expression patterns of μ- and m-calpain in mammalian tissues suggest they have some isoform specific and distinct functions.
T3382 594-601 IN denotes Despite
T3384 602-607 DT denotes these
T3385 608-620 NNS denotes similarities
T3386 620-622 , denotes ,
T3387 622-625 DT denotes the
T3389 626-638 JJ denotes differential
T3390 639-649 NN denotes expression
T3388 650-658 NNS denotes patterns
T3391 659-661 IN denotes of
T3392 662-663 NN denotes μ
T3394 663-664 HYPH denotes -
T3395 665-668 CC denotes and
T3396 669-670 NN denotes m
T3397 670-671 HYPH denotes -
T3393 671-678 NN denotes calpain
T3398 679-681 IN denotes in
T3399 682-691 JJ denotes mammalian
T3400 692-699 NNS denotes tissues
T3383 700-707 VBP denotes suggest
T3401 708-712 PRP denotes they
T3402 713-717 VBP denotes have
T3403 718-722 DT denotes some
T3405 723-730 NN denotes isoform
T3406 731-739 JJ denotes specific
T3407 740-743 CC denotes and
T3408 744-752 JJ denotes distinct
T3404 753-762 NNS denotes functions
T3409 762-763 . denotes .
T3410 763-925 sentence denotes The μ and m designations derive from the levels of Ca2+ required in vitro for optimal activation; 10–50 μM Ca2+ for μ-calpain and 0.3–0.35 mM Ca2+ for m-calpain.
T3411 764-767 DT denotes The
T3413 768-769 NN denotes μ
T3414 770-773 CC denotes and
T3415 774-775 NN denotes m
T3412 776-788 NNS denotes designations
T3416 789-795 VBP denotes derive
T3417 796-800 IN denotes from
T3418 801-804 DT denotes the
T3419 805-811 NNS denotes levels
T3420 812-814 IN denotes of
T3421 815-818 NN denotes Ca2
T3422 818-819 SYM denotes +
T3423 820-828 VBN denotes required
T3424 829-831 FW denotes in
T3425 832-837 FW denotes vitro
T3426 838-841 IN denotes for
T3427 842-849 JJ denotes optimal
T3428 850-860 NN denotes activation
T3429 860-861 : denotes ;
T3430 862-864 CD denotes 10
T3432 864-865 SYM denotes –
T3431 865-867 CD denotes 50
T3433 868-870 NN denotes μM
T3434 871-874 NN denotes Ca2
T3435 874-875 SYM denotes +
T3436 876-879 IN denotes for
T3437 880-881 NN denotes μ
T3439 881-882 HYPH denotes -
T3438 882-889 NN denotes calpain
T3440 890-893 CC denotes and
T3441 894-897 CD denotes 0.3
T3443 897-898 SYM denotes –
T3442 898-902 CD denotes 0.35
T3444 903-905 NN denotes mM
T3445 906-909 NN denotes Ca2
T3446 909-910 SYM denotes +
T3447 911-914 IN denotes for
T3448 915-916 NN denotes m
T3450 916-917 HYPH denotes -
T3449 917-924 NN denotes calpain
T3451 924-925 . denotes .
T3452 925-1087 sentence denotes It is generally assumed that μ- and m-calpain maintain their differential sensitivities to calcium in vivo, although this has not yet been strictly demonstrated.
T3453 926-928 PRP denotes It
T3455 929-931 VBZ denotes is
T3456 932-941 RB denotes generally
T3454 942-949 VBN denotes assumed
T3457 950-954 IN denotes that
T3459 955-956 NN denotes μ
T3461 956-957 HYPH denotes -
T3462 958-961 CC denotes and
T3463 962-963 NN denotes m
T3464 963-964 HYPH denotes -
T3460 964-971 NN denotes calpain
T3458 972-980 VBP denotes maintain
T3465 981-986 PRP$ denotes their
T3467 987-999 JJ denotes differential
T3466 1000-1013 NNS denotes sensitivities
T3468 1014-1016 IN denotes to
T3469 1017-1024 NN denotes calcium
T3470 1025-1027 FW denotes in
T3471 1028-1032 FW denotes vivo
T3472 1032-1034 , denotes ,
T3473 1034-1042 IN denotes although
T3475 1043-1047 DT denotes this
T3476 1048-1051 VBZ denotes has
T3477 1052-1055 RB denotes not
T3478 1056-1059 RB denotes yet
T3479 1060-1064 VBN denotes been
T3480 1065-1073 RB denotes strictly
T3474 1074-1086 VBN denotes demonstrated
T3481 1086-1087 . denotes .
T3482 1087-1273 sentence denotes Furthermore, since the cytoplasmic free Ca2+ concentration is typically less than 1 μM, it is also assumed that other in vivo factors must contribute to regulation of these enzymes [3].
T3483 1088-1099 RB denotes Furthermore
T3485 1099-1101 , denotes ,
T3486 1101-1106 IN denotes since
T3488 1107-1110 DT denotes the
T3490 1111-1122 JJ denotes cytoplasmic
T3491 1123-1127 JJ denotes free
T3492 1128-1131 NN denotes Ca2
T3493 1131-1132 SYM denotes +
T3489 1133-1146 NN denotes concentration
T3487 1147-1149 VBZ denotes is
T3494 1150-1159 RB denotes typically
T3495 1160-1164 JJR denotes less
T3497 1165-1169 IN denotes than
T3496 1170-1171 CD denotes 1
T3498 1172-1174 NN denotes μM
T3499 1174-1176 , denotes ,
T3500 1176-1178 PRP denotes it
T3501 1179-1181 VBZ denotes is
T3502 1182-1186 RB denotes also
T3484 1187-1194 VBN denotes assumed
T3503 1195-1199 IN denotes that
T3505 1200-1205 JJ denotes other
T3507 1206-1208 FW denotes in
T3508 1209-1213 FW denotes vivo
T3506 1214-1221 NNS denotes factors
T3509 1222-1226 MD denotes must
T3504 1227-1237 VB denotes contribute
T3510 1238-1240 IN denotes to
T3511 1241-1251 NN denotes regulation
T3512 1252-1254 IN denotes of
T3513 1255-1260 DT denotes these
T3514 1261-1268 NNS denotes enzymes
T3515 1269-1270 -LRB- denotes [
T3516 1270-1271 CD denotes 3
T3517 1271-1272 -RRB- denotes ]
T3518 1272-1273 . denotes .
R282 T3323 T3320 nummod 80,k
R287 T3324 T3320 punct ),k
R288 T3325 T3306 punct ", ",encoded
R289 T3326 T3306 advmod respectively,encoded
R290 T3244 T3245 det The,proteases
R291 T3327 T3301 punct ", ",subunits
R292 T3245 T3254 nsubj proteases,are
R293 T3246 T3245 nummod two,proteases
R294 T3328 T3329 dep that,associate
R295 T3247 T3245 amod ubiquitous,proteases
R296 T3248 T3249 npadvmod Ca2,dependent
R297 T3329 T3301 relcl associate,subunits
R298 T3249 T3245 amod dependent,proteases
R299 T3250 T3248 punct +,Ca2
R300 T3251 T3249 punct -,dependent
R301 T3330 T3329 prep with,associate
R302 T3252 T3245 punct ", ",proteases
R303 T3253 T3245 compound cysteine,proteases
R304 T3255 T3245 acl known,proteases
R305 T3331 T3332 det a,subunit
R306 T3256 T3255 prep as,known
R307 T3257 T3258 compound μ,calpain
R308 T3258 T3256 pobj calpain,as
R309 T3332 T3330 pobj subunit,with
R310 T3259 T3258 punct -,calpain
R311 T3260 T3258 punct (,calpain
R312 T3261 T3258 appos calpain,calpain
R313 T3333 T3332 amod common,subunit
R314 T3262 T3261 punct -,calpain
R315 T3263 T3261 nummod 1,calpain
R316 T3264 T3258 punct ),calpain
R317 T3334 T3335 nummod 28,kDa
R318 T3265 T3258 cc and,calpain
R319 T3335 T3332 nmod kDa,subunit
R320 T3266 T3267 compound m,calpain
R321 T3267 T3258 conj calpain,calpain
R322 T3268 T3267 punct -,calpain
R323 T3269 T3267 punct (,calpain
R324 T3270 T3267 appos capain,calpain
R325 T3271 T3270 punct -,capain
R326 T3272 T3270 nummod 2,capain
R327 T3273 T3254 punct ),are
R328 T3274 T3254 punct ", ",are
R329 T3275 T3276 det the,members
R330 T3276 T3254 attr members,are
R331 T3277 T3276 compound founding,members
R332 T3278 T3276 prep of,members
R333 T3336 T3332 amod regulatory,subunit
R334 T3279 T3280 det a,family
R335 T3280 T3278 pobj family,of
R336 T3281 T3280 compound gene,family
R337 T3282 T3280 acl comprising,family
R338 T3337 T3332 acl encoded,subunit
R339 T3283 T3284 nummod 13,genes
R340 T3284 T3282 dobj genes,comprising
R341 T3285 T3282 prep in,comprising
R342 T3338 T3337 agent by,encoded
R343 T3286 T3285 pobj mammals,in
R344 T3287 T3288 punct [,1
R345 T3288 T3254 parataxis 1,are
R346 T3339 T3340 det the,gene
R347 T3289 T3290 punct -,3
R348 T3290 T3288 prep 3,1
R349 T3291 T3288 punct ],1
R350 T3340 T3338 pobj gene,by
R351 T3292 T3254 punct .,are
R352 T3341 T3340 compound Capn4,gene
R353 T3294 T3295 nsubj Both,are
R354 T3296 T3297 amod heterodimeric,enzymes
R355 T3342 T3295 punct .,are
R356 T3297 T3295 attr enzymes,are
R357 T3298 T3297 acl consisting,enzymes
R358 T3299 T3298 prep of,consisting
R359 T3344 T3345 det The,subunits
R360 T3300 T3301 amod distinct,subunits
R361 T3301 T3299 pobj subunits,of
R362 T3302 T3303 nummod 80,kDa
R363 T3303 T3301 nmod kDa,subunits
R364 T3345 T3355 nsubj subunits,share
R365 T3304 T3301 amod catalytic,subunits
R366 T3305 T3301 punct ", ",subunits
R367 T3346 T3347 nmod μ,k
R368 T3347 T3345 nmod k,subunits
R369 T3306 T3301 acl encoded,subunits
R370 T3307 T3306 agent by,encoded
R371 T3348 T3346 punct -,μ
R372 T3308 T3309 det the,genes
R373 T3309 T3307 pobj genes,by
R374 T3310 T3309 nmod Capn1,genes
R375 T3311 T3312 punct (,k
R376 T3349 T3346 nummod 80,μ
R377 T3312 T3310 parataxis k,Capn1
R378 T3313 T3312 nmod μ,k
R379 T3314 T3312 punct -,k
R380 T3315 T3312 nummod 80,k
R381 T3350 T3347 cc and,k
R382 T3316 T3312 punct ),k
R383 T3317 T3310 cc and,Capn1
R384 T3318 T3310 conj Capn2,Capn1
R385 T3351 T3352 nmod m,k
R386 T3319 T3320 punct (,k
R387 T3320 T3318 parataxis k,Capn2
R388 T3321 T3320 nmod m,k
R389 T3352 T3347 conj k,k
R390 T3322 T3320 punct -,k
R391 T3353 T3351 punct -,m
R392 T3354 T3351 nummod 80,m
R393 T3356 T3357 nummod 62,%
R394 T3429 T3419 punct ;,levels
R395 T3357 T3358 compound %,identity
R396 T3430 T3431 quantmod 10,50
R397 T3431 T3433 nummod 50,μM
R398 T3358 T3355 dobj identity,share
R399 T3432 T3431 punct –,50
R400 T3433 T3434 compound μM,Ca2
R401 T3434 T3419 appos Ca2,levels
R402 T3359 T3360 compound amino,acid
R403 T3435 T3434 punct +,Ca2
R404 T3436 T3434 prep for,Ca2
R405 T3437 T3438 compound μ,calpain
R406 T3360 T3358 compound acid,identity
R407 T3438 T3436 pobj calpain,for
R408 T3439 T3438 punct -,calpain
R409 T3440 T3434 cc and,Ca2
R410 T3361 T3358 compound sequence,identity
R411 T3441 T3442 quantmod 0.3,0.35
R412 T3442 T3444 nummod 0.35,mM
R413 T3443 T3442 punct –,0.35
R414 T3362 T3355 punct ", ",share
R415 T3444 T3445 compound mM,Ca2
R416 T3445 T3434 conj Ca2,Ca2
R417 T3363 T3355 cc and,share
R418 T3446 T3445 punct +,Ca2
R419 T3447 T3445 prep for,Ca2
R420 T3448 T3449 compound m,calpain
R421 T3449 T3447 pobj calpain,for
R422 T3364 T3355 conj are,share
R423 T3450 T3449 punct -,calpain
R424 T3451 T3416 punct .,derive
R425 T3453 T3454 nsubjpass It,assumed
R426 T3365 T3366 advmod very,similar
R427 T3455 T3454 auxpass is,assumed
R428 T3456 T3454 advmod generally,assumed
R429 T3457 T3458 mark that,maintain
R430 T3366 T3364 acomp similar,are
R431 T3458 T3454 ccomp maintain,assumed
R432 T3459 T3460 nmod μ,calpain
R433 T3367 T3364 prep in,are
R434 T3460 T3458 nsubj calpain,maintain
R435 T3461 T3459 punct -,μ
R436 T3462 T3459 cc and,μ
R437 T3463 T3459 conj m,μ
R438 T3368 T3367 pobj terms,in
R439 T3464 T3460 punct -,calpain
R440 T3465 T3466 poss their,sensitivities
R441 T3466 T3458 dobj sensitivities,maintain
R442 T3369 T3368 prep of,terms
R443 T3467 T3466 amod differential,sensitivities
R444 T3468 T3466 prep to,sensitivities
R445 T3370 T3369 pobj structure,of
R446 T3469 T3468 pobj calcium,to
R447 T3470 T3471 advmod in,vivo
R448 T3471 T3458 advmod vivo,maintain
R449 T3371 T3370 punct ", ",structure
R450 T3472 T3458 punct ", ",maintain
R451 T3473 T3474 mark although,demonstrated
R452 T3372 T3373 compound protein,chemistry
R453 T3373 T3370 conj chemistry,structure
R454 T3474 T3458 advcl demonstrated,maintain
R455 T3475 T3474 nsubjpass this,demonstrated
R456 T3476 T3474 aux has,demonstrated
R457 T3374 T3373 punct ", ",chemistry
R458 T3477 T3474 neg not,demonstrated
R459 T3478 T3474 advmod yet,demonstrated
R460 T3375 T3373 cc and,chemistry
R461 T3479 T3474 auxpass been,demonstrated
R462 T3480 T3474 advmod strictly,demonstrated
R463 T3481 T3454 punct .,assumed
R464 T3376 T3377 advmod in,vitro
R465 T3483 T3484 advmod Furthermore,assumed
R466 T3377 T3378 amod vitro,specificity
R467 T3485 T3484 punct ", ",assumed
R468 T3486 T3487 mark since,is
R469 T3378 T3373 conj specificity,chemistry
R470 T3487 T3484 advcl is,assumed
R471 T3488 T3489 det the,concentration
R472 T3379 T3378 compound substrate,specificity
R473 T3489 T3487 nsubj concentration,is
R474 T3490 T3491 amod cytoplasmic,free
R475 T3491 T3489 amod free,concentration
R476 T3380 T3355 punct .,share
R477 T3492 T3489 nmod Ca2,concentration
R478 T3493 T3492 punct +,Ca2
R479 T3494 T3487 advmod typically,is
R480 T3495 T3496 amod less,1
R481 T3496 T3498 nummod 1,μM
R482 T3497 T3496 quantmod than,1
R483 T3382 T3383 prep Despite,suggest
R484 T3498 T3487 attr μM,is
R485 T3499 T3484 punct ", ",assumed
R486 T3500 T3484 nsubjpass it,assumed
R487 T3501 T3484 auxpass is,assumed
R488 T3384 T3385 det these,similarities
R489 T3502 T3484 advmod also,assumed
R490 T3503 T3504 mark that,contribute
R491 T3504 T3484 ccomp contribute,assumed
R492 T3505 T3506 amod other,factors
R493 T3506 T3504 nsubj factors,contribute
R494 T3385 T3382 pobj similarities,Despite
R495 T3507 T3508 advmod in,vivo
R496 T3508 T3506 amod vivo,factors
R497 T3509 T3504 aux must,contribute
R498 T3510 T3504 prep to,contribute
R499 T3386 T3383 punct ", ",suggest
R500 T3511 T3510 pobj regulation,to
R501 T3512 T3511 prep of,regulation
R502 T3387 T3388 det the,patterns
R503 T3513 T3514 det these,enzymes
R504 T3514 T3512 pobj enzymes,of
R505 T3515 T3516 punct [,3
R506 T3388 T3383 nsubj patterns,suggest
R507 T3516 T3504 parataxis 3,contribute
R508 T3517 T3516 punct ],3
R509 T3518 T3484 punct .,assumed
R511 T3389 T3388 amod differential,patterns
R514 T3390 T3388 compound expression,patterns
R518 T3391 T3388 prep of,patterns
R522 T3392 T3393 nmod μ,calpain
R526 T3393 T3391 pobj calpain,of
R529 T3394 T3392 punct -,μ
R531 T3395 T3392 cc and,μ
R536 T3396 T3392 conj m,μ
R540 T3397 T3393 punct -,calpain
R542 T3398 T3388 prep in,patterns
R545 T3399 T3400 amod mammalian,tissues
R549 T3400 T3398 pobj tissues,in
R552 T3401 T3402 nsubj they,have
R556 T3402 T3383 advcl have,suggest
R560 T3403 T3404 det some,functions
R562 T3404 T3402 dobj functions,have
R564 T3405 T3406 npadvmod isoform,specific
R568 T3406 T3404 amod specific,functions
R570 T3407 T3406 cc and,specific
R572 T3408 T3406 conj distinct,specific
R575 T3409 T3383 punct .,suggest
R578 T3411 T3412 det The,designations
R586 T3412 T3416 nsubj designations,derive
R589 T3413 T3412 nmod μ,designations
R593 T3414 T3413 cc and,μ
R597 T3415 T3413 conj m,μ
R601 T3417 T3416 prep from,derive
R606 T3418 T3419 det the,levels
R610 T3419 T3417 pobj levels,from
R615 T3420 T3419 prep of,levels
R618 T3421 T3420 pobj Ca2,of
R622 T3422 T3421 punct +,Ca2
R626 T3423 T3419 acl required,levels
R630 T3424 T3425 advmod in,vitro
R637 T3425 T3423 advmod vitro,required
R640 T3426 T3423 prep for,required
R645 T3427 T3428 amod optimal,activation
R649 T3428 T3426 pobj activation,for