PMC:1359071 / 6169-13302 JSON TXT 4 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id	Subject	Object	Predicate	Lexical cue
T4641	0-4	NNS	denotes	QTLs
T4642	5-15	VBN	denotes	Associated
T4643	16-20	IN	denotes	with
T4644	21-28	JJ	denotes	Gonadal
T4646	29-32	NN	denotes	Fat
T4645	33-37	NN	denotes	Mass
T4647	37-174	sentence	denotes	Characteristics of the B6.ApoE−/− and C3H.ApoE−/− parents and the F2 BXH.ApoE−/− generation on a Western diet are summarized in Table 1.
T4648	38-53	NNS	denotes	Characteristics
T4650	54-56	IN	denotes	of
T4651	57-60	DT	denotes	the
T4653	61-68	NN	denotes	B6.ApoE
T4654	68-69	SYM	denotes	−
T4655	69-70	HYPH	denotes	/
T4656	70-71	SYM	denotes	−
T4657	72-75	CC	denotes	and
T4658	76-84	NN	denotes	C3H.ApoE
T4659	84-85	SYM	denotes	−
T4660	85-86	HYPH	denotes	/
T4661	86-87	SYM	denotes	−
T4652	88-95	NNS	denotes	parents
T4662	96-99	CC	denotes	and
T4663	100-103	DT	denotes	the
T4665	104-106	NN	denotes	F2
T4666	107-115	NN	denotes	BXH.ApoE
T4667	115-116	SYM	denotes	−
T4668	116-117	HYPH	denotes	/
T4669	117-118	SYM	denotes	−
T4664	119-129	NN	denotes	generation
T4670	130-132	IN	denotes	on
T4671	133-134	DT	denotes	a
T4673	135-142	NNP	denotes	Western
T4672	143-147	NN	denotes	diet
T4674	148-151	VBP	denotes	are
T4649	152-162	VBN	denotes	summarized
T4675	163-165	IN	denotes	in
T4676	166-171	NN	denotes	Table
T4677	172-173	CD	denotes	1
T4678	173-174	.	denotes	.
T4679	174-321	sentence	denotes	Gonadal fat mass differed significantly between the sexes in F2 (p < 10−4) and in the parental C3H.ApoE−/− (p < 0.05), but not in B6.ApoE−/− mice.
T4680	175-182	JJ	denotes	Gonadal
T4682	183-186	NN	denotes	fat
T4681	187-191	NN	denotes	mass
T4683	192-200	VBD	denotes	differed
T4684	201-214	RB	denotes	significantly
T4685	215-222	IN	denotes	between
T4686	223-226	DT	denotes	the
T4687	227-232	NNS	denotes	sexes
T4688	233-235	IN	denotes	in
T4689	236-238	NN	denotes	F2
T4690	239-240	-LRB-	denotes	(
T4692	240-241	NN	denotes	p
T4693	242-243	SYM	denotes	<
T4694	244-246	CD	denotes	10
T4695	246-247	SYM	denotes	−
T4691	247-248	CD	denotes	4
T4696	248-249	-RRB-	denotes	)
T4697	250-253	CC	denotes	and
T4698	254-256	IN	denotes	in
T4699	257-260	DT	denotes	the
T4701	261-269	JJ	denotes	parental
T4700	270-278	NN	denotes	C3H.ApoE
T4702	278-279	SYM	denotes	−
T4703	279-280	HYPH	denotes	/
T4704	280-281	SYM	denotes	−
T4705	282-283	-LRB-	denotes	(
T4707	283-284	NN	denotes	p
T4708	285-286	SYM	denotes	<
T4706	287-291	CD	denotes	0.05
T4709	291-292	-RRB-	denotes	)
T4710	292-294	,	denotes	,
T4711	294-297	CC	denotes	but
T4712	298-301	RB	denotes	not
T4713	302-304	IN	denotes	in
T4714	305-312	NN	denotes	B6.ApoE
T4716	312-313	SYM	denotes	−
T4717	313-314	HYPH	denotes	/
T4718	314-315	SYM	denotes	−
T4715	316-320	NNS	denotes	mice
T4719	320-321	.	denotes	.
T4720	321-475	sentence	denotes	Gonadal fat mass was the fat pad collection that represented the most animals and the most accurate collections and was thus chosen for further analysis.
T4721	322-329	JJ	denotes	Gonadal
T4723	330-333	NN	denotes	fat
T4722	334-338	NN	denotes	mass
T4724	339-342	VBD	denotes	was
T4725	343-346	DT	denotes	the
T4727	347-350	NN	denotes	fat
T4728	351-354	NN	denotes	pad
T4726	355-365	NN	denotes	collection
T4729	366-370	WDT	denotes	that
T4730	371-382	VBD	denotes	represented
T4731	383-386	DT	denotes	the
T4733	387-391	JJS	denotes	most
T4732	392-399	NNS	denotes	animals
T4734	400-403	CC	denotes	and
T4735	404-407	DT	denotes	the
T4737	408-412	RBS	denotes	most
T4738	413-421	JJ	denotes	accurate
T4736	422-433	NNS	denotes	collections
T4739	434-437	CC	denotes	and
T4740	438-441	VBD	denotes	was
T4742	442-446	RB	denotes	thus
T4741	447-453	VBN	denotes	chosen
T4743	454-457	IN	denotes	for
T4744	458-465	JJ	denotes	further
T4745	466-474	NN	denotes	analysis
T4746	474-475	.	denotes	.
T4747	475-745	sentence	denotes	Broad sense heritability (h 2) calculated as (σ2 Total − σ2 Parental)/σ2 Total for the gonadal fat mass trait was 54% for females and 36% for males, which is in close agreement with previous reports [18,19] and demonstrates significant heritability of gonadal fat mass.
T4748	476-481	JJ	denotes	Broad
T4749	482-487	NN	denotes	sense
T4750	488-500	NN	denotes	heritability
T4752	501-502	-LRB-	denotes	(
T4753	502-505	NN	denotes	h 2
T4754	505-506	-RRB-	denotes	)
T4755	507-517	VBN	denotes	calculated
T4756	518-520	IN	denotes	as
T4757	521-522	-LRB-	denotes	(
T4758	522-530	NN	denotes	σ2 Total
T4760	531-532	SYM	denotes	−
T4759	533-544	NN	denotes	σ2 Parental
T4761	544-545	-RRB-	denotes	)
T4762	545-546	HYPH	denotes	/
T4763	546-554	NN	denotes	σ2 Total
T4764	555-558	IN	denotes	for
T4765	559-562	DT	denotes	the
T4767	563-570	JJ	denotes	gonadal
T4769	571-574	NN	denotes	fat
T4768	575-579	NN	denotes	mass
T4766	580-585	NN	denotes	trait
T4751	586-589	VBD	denotes	was
T4770	590-592	CD	denotes	54
T4771	592-593	NN	denotes	%
T4772	594-597	IN	denotes	for
T4773	598-605	NNS	denotes	females
T4774	606-609	CC	denotes	and
T4775	610-612	CD	denotes	36
T4776	612-613	NN	denotes	%
T4777	614-617	IN	denotes	for
T4778	618-623	NNS	denotes	males
T4779	623-625	,	denotes	,
T4780	625-630	WDT	denotes	which
T4781	631-633	VBZ	denotes	is
T4782	634-636	IN	denotes	in
T4783	637-642	JJ	denotes	close
T4784	643-652	NN	denotes	agreement
T4785	653-657	IN	denotes	with
T4786	658-666	JJ	denotes	previous
T4787	667-674	NNS	denotes	reports
T4788	675-676	-LRB-	denotes	[
T4790	676-678	CD	denotes	18
T4791	678-679	,	denotes	,
T4789	679-681	CD	denotes	19
T4792	681-682	-RRB-	denotes	]
T4793	683-686	CC	denotes	and
T4794	687-699	VBZ	denotes	demonstrates
T4795	700-711	JJ	denotes	significant
T4796	712-724	NN	denotes	heritability
T4797	725-727	IN	denotes	of
T4798	728-735	JJ	denotes	gonadal
T4800	736-739	NN	denotes	fat
T4799	740-744	NN	denotes	mass
T4801	744-745	.	denotes	.
T4802	745-940	sentence	denotes	Table 1 Characteristics of the BXH.ApoE−/− Cross A total of 334 F2 mice were genotyped at an average 1.5 cM density using 1,032 single nucleotide polymorphisms (SNPs) spanning all 19 autosomes.
T4803	796-797	DT	denotes	A
T4804	798-803	NN	denotes	total
T4806	804-806	IN	denotes	of
T4807	807-810	CD	denotes	334
T4809	811-813	NN	denotes	F2
T4808	814-818	NNS	denotes	mice
T4810	819-823	VBD	denotes	were
T4805	824-833	VBN	denotes	genotyped
T4811	834-836	IN	denotes	at
T4812	837-839	DT	denotes	an
T4814	840-847	JJ	denotes	average
T4815	848-851	CD	denotes	1.5
T4816	852-854	NN	denotes	cM
T4813	855-862	NN	denotes	density
T4817	863-868	VBG	denotes	using
T4818	869-874	CD	denotes	1,032
T4820	875-881	JJ	denotes	single
T4821	882-892	NN	denotes	nucleotide
T4819	893-906	NNS	denotes	polymorphisms
T4822	907-908	-LRB-	denotes	(
T4823	908-912	NNS	denotes	SNPs
T4824	912-913	-RRB-	denotes	)
T4825	914-922	VBG	denotes	spanning
T4826	923-926	DT	denotes	all
T4828	927-929	CD	denotes	19
T4827	930-939	NNS	denotes	autosomes
T4829	939-940	.	denotes	.
T4830	940-1201	sentence	denotes	QTL analysis for several clinical traits (clinical QTLs [cQTLs]), including the unadjusted raw values for gonadal fat mass, was performed using a single marker regression approach (justified by the high-density of markers, making interval mapping unnecessary).
T4831	941-944	NN	denotes	QTL
T4832	945-953	NN	denotes	analysis
T4834	954-957	IN	denotes	for
T4835	958-965	JJ	denotes	several
T4837	966-974	JJ	denotes	clinical
T4836	975-981	NNS	denotes	traits
T4838	982-983	-LRB-	denotes	(
T4840	983-991	JJ	denotes	clinical
T4839	992-996	NNS	denotes	QTLs
T4841	997-998	-LRB-	denotes	[
T4842	998-1003	NNS	denotes	cQTLs
T4843	1003-1004	-RRB-	denotes	]
T4844	1004-1005	-RRB-	denotes	)
T4845	1005-1007	,	denotes	,
T4846	1007-1016	VBG	denotes	including
T4847	1017-1020	DT	denotes	the
T4849	1021-1031	JJ	denotes	unadjusted
T4850	1032-1035	JJ	denotes	raw
T4848	1036-1042	NNS	denotes	values
T4851	1043-1046	IN	denotes	for
T4852	1047-1054	JJ	denotes	gonadal
T4854	1055-1058	NN	denotes	fat
T4853	1059-1063	NN	denotes	mass
T4855	1063-1065	,	denotes	,
T4856	1065-1068	VBD	denotes	was
T4833	1069-1078	VBN	denotes	performed
T4857	1079-1084	VBG	denotes	using
T4858	1085-1086	DT	denotes	a
T4860	1087-1093	JJ	denotes	single
T4861	1094-1100	NN	denotes	marker
T4862	1101-1111	NN	denotes	regression
T4859	1112-1120	NN	denotes	approach
T4863	1121-1122	-LRB-	denotes	(
T4864	1122-1131	VBN	denotes	justified
T4865	1132-1134	IN	denotes	by
T4866	1135-1138	DT	denotes	the
T4868	1139-1143	NN	denotes	high
T4869	1143-1144	HYPH	denotes	-
T4867	1144-1151	NN	denotes	density
T4870	1152-1154	IN	denotes	of
T4871	1155-1162	NNS	denotes	markers
T4872	1162-1164	,	denotes	,
T4873	1164-1170	VBG	denotes	making
T4874	1171-1179	NN	denotes	interval
T4875	1180-1187	NN	denotes	mapping
T4876	1188-1199	JJ	denotes	unnecessary
T4877	1199-1200	-RRB-	denotes	)
T4878	1200-1201	.	denotes	.
T4879	1201-1387	sentence	denotes	In order to test specifically for sex effects of linkage, we included additive, dominant, sex, sex-additive, and sex-dominant parameters in our calculations (see Materials and Methods).
T4880	1202-1204	IN	denotes	In
T4882	1205-1210	NN	denotes	order
T4883	1211-1213	TO	denotes	to
T4884	1214-1218	VB	denotes	test
T4885	1219-1231	RB	denotes	specifically
T4886	1232-1235	IN	denotes	for
T4887	1236-1239	NN	denotes	sex
T4888	1240-1247	NNS	denotes	effects
T4889	1248-1250	IN	denotes	of
T4890	1251-1258	NN	denotes	linkage
T4891	1258-1260	,	denotes	,
T4892	1260-1262	PRP	denotes	we
T4881	1263-1271	VBD	denotes	included
T4893	1272-1280	JJ	denotes	additive
T4895	1280-1282	,	denotes	,
T4896	1282-1290	JJ	denotes	dominant
T4897	1290-1292	,	denotes	,
T4898	1292-1295	NN	denotes	sex
T4899	1295-1297	,	denotes	,
T4900	1297-1300	NN	denotes	sex
T4902	1300-1301	HYPH	denotes	-
T4901	1301-1309	JJ	denotes	additive
T4903	1309-1311	,	denotes	,
T4904	1311-1314	CC	denotes	and
T4905	1315-1318	NN	denotes	sex
T4907	1318-1319	HYPH	denotes	-
T4906	1319-1327	JJ	denotes	dominant
T4894	1328-1338	NNS	denotes	parameters
T4908	1339-1341	IN	denotes	in
T4909	1342-1345	PRP$	denotes	our
T4910	1346-1358	NNS	denotes	calculations
T4911	1359-1360	-LRB-	denotes	(
T4912	1360-1363	VB	denotes	see
T4913	1364-1373	NNS	denotes	Materials
T4914	1374-1377	CC	denotes	and
T4915	1378-1385	NNS	denotes	Methods
T4916	1385-1386	-RRB-	denotes	)
T4917	1386-1387	.	denotes	.
T4918	1387-1597	sentence	denotes	A stepwise regression procedure was used to determine whether the addition of the final two terms significantly improved the linear regression model, conditional on realizing a significant additive QTL effect.
T4919	1388-1389	DT	denotes	A
T4921	1390-1398	JJ	denotes	stepwise
T4922	1399-1409	NN	denotes	regression
T4920	1410-1419	NN	denotes	procedure
T4924	1420-1423	VBD	denotes	was
T4923	1424-1428	VBN	denotes	used
T4925	1429-1431	TO	denotes	to
T4926	1432-1441	VB	denotes	determine
T4927	1442-1449	IN	denotes	whether
T4929	1450-1453	DT	denotes	the
T4930	1454-1462	NN	denotes	addition
T4931	1463-1465	IN	denotes	of
T4932	1466-1469	DT	denotes	the
T4934	1470-1475	JJ	denotes	final
T4935	1476-1479	CD	denotes	two
T4933	1480-1485	NNS	denotes	terms
T4936	1486-1499	RB	denotes	significantly
T4928	1500-1508	VBN	denotes	improved
T4937	1509-1512	DT	denotes	the
T4939	1513-1519	JJ	denotes	linear
T4940	1520-1530	NN	denotes	regression
T4938	1531-1536	NN	denotes	model
T4941	1536-1538	,	denotes	,
T4942	1538-1549	JJ	denotes	conditional
T4943	1550-1552	IN	denotes	on
T4944	1553-1562	VBG	denotes	realizing
T4945	1563-1564	DT	denotes	a
T4947	1565-1576	JJ	denotes	significant
T4948	1577-1585	JJ	denotes	additive
T4949	1586-1589	NN	denotes	QTL
T4946	1590-1596	NN	denotes	effect
T4950	1596-1597	.	denotes	.
T4951	1597-1807	sentence	denotes	We performed permutation analyses over all gene expression traits, estimating false discovery rates (FDRs) at different logarithm of odds (LOD) score thresholds and assessing the overall rate of QTL detection.
T4952	1598-1600	PRP	denotes	We
T4953	1601-1610	VBD	denotes	performed
T4954	1611-1622	NN	denotes	permutation
T4955	1623-1631	NNS	denotes	analyses
T4956	1632-1636	IN	denotes	over
T4957	1637-1640	DT	denotes	all
T4959	1641-1645	NN	denotes	gene
T4960	1646-1656	NN	denotes	expression
T4958	1657-1663	NNS	denotes	traits
T4961	1663-1665	,	denotes	,
T4962	1665-1675	VBG	denotes	estimating
T4963	1676-1681	JJ	denotes	false
T4965	1682-1691	NN	denotes	discovery
T4964	1692-1697	NNS	denotes	rates
T4966	1698-1699	-LRB-	denotes	(
T4967	1699-1703	NNS	denotes	FDRs
T4968	1703-1704	-RRB-	denotes	)
T4969	1705-1707	IN	denotes	at
T4970	1708-1717	JJ	denotes	different
T4972	1718-1727	NN	denotes	logarithm
T4973	1728-1730	IN	denotes	of
T4974	1731-1735	NNS	denotes	odds
T4975	1736-1737	-LRB-	denotes	(
T4976	1737-1740	NN	denotes	LOD
T4977	1740-1741	-RRB-	denotes	)
T4978	1742-1747	NN	denotes	score
T4971	1748-1758	NNS	denotes	thresholds
T4979	1759-1762	CC	denotes	and
T4980	1763-1772	VBG	denotes	assessing
T4981	1773-1776	DT	denotes	the
T4983	1777-1784	JJ	denotes	overall
T4982	1785-1789	NN	denotes	rate
T4984	1790-1792	IN	denotes	of
T4985	1793-1796	NN	denotes	QTL
T4986	1797-1806	NN	denotes	detection
T4987	1806-1807	.	denotes	.
T4988	1807-2093	sentence	denotes	From these analyses we constructed receiver operating characteristic (ROC)-like curves to demonstrate that our straightforward method has significantly increased power to detect QTLs compared to QTL mapping methods that do not incorporate sex and genotype–sex interactions (Figure S1).
T4989	1808-1812	IN	denotes	From
T4991	1813-1818	DT	denotes	these
T4992	1819-1827	NNS	denotes	analyses
T4993	1828-1830	PRP	denotes	we
T4990	1831-1842	VBD	denotes	constructed
T4994	1843-1851	NN	denotes	receiver
T4995	1852-1861	NN	denotes	operating
T4997	1862-1876	JJ	denotes	characteristic
T4998	1877-1878	-LRB-	denotes	(
T4999	1878-1881	NN	denotes	ROC
T5000	1881-1882	-RRB-	denotes	)
T5001	1882-1883	HYPH	denotes	-
T4996	1883-1887	JJ	denotes	like
T5002	1888-1894	NNS	denotes	curves
T5003	1895-1897	TO	denotes	to
T5004	1898-1909	VB	denotes	demonstrate
T5005	1910-1914	IN	denotes	that
T5007	1915-1918	PRP$	denotes	our
T5009	1919-1934	JJ	denotes	straightforward
T5008	1935-1941	NN	denotes	method
T5006	1942-1945	VBZ	denotes	has
T5010	1946-1959	RB	denotes	significantly
T5011	1960-1969	JJ	denotes	increased
T5012	1970-1975	NN	denotes	power
T5013	1976-1978	TO	denotes	to
T5014	1979-1985	VB	denotes	detect
T5015	1986-1990	NNS	denotes	QTLs
T5016	1991-1999	VBN	denotes	compared
T5017	2000-2002	IN	denotes	to
T5018	2003-2006	NN	denotes	QTL
T5020	2007-2014	NN	denotes	mapping
T5019	2015-2022	NNS	denotes	methods
T5021	2023-2027	WDT	denotes	that
T5023	2028-2030	VBP	denotes	do
T5024	2031-2034	RB	denotes	not
T5022	2035-2046	VB	denotes	incorporate
T5025	2047-2050	NN	denotes	sex
T5026	2051-2054	CC	denotes	and
T5027	2055-2063	NN	denotes	genotype
T5029	2063-2064	HYPH	denotes	–
T5028	2064-2067	NN	denotes	sex
T5030	2068-2080	NNS	denotes	interactions
T5031	2081-2082	-LRB-	denotes	(
T5033	2082-2088	NN	denotes	Figure
T5032	2089-2091	NN	denotes	S1
T5034	2091-2092	-RRB-	denotes	)
T5035	2092-2093	.	denotes	.
T5036	2093-2238	sentence	denotes	It is clear from the ROC curves that the sex and sex-interaction terms add significantly to the detection of QTL for the gene expression traits.
T5037	2094-2096	PRP	denotes	It
T5038	2097-2099	VBZ	denotes	is
T5039	2100-2105	JJ	denotes	clear
T5040	2106-2110	IN	denotes	from
T5041	2111-2114	DT	denotes	the
T5043	2115-2118	NN	denotes	ROC
T5042	2119-2125	NNS	denotes	curves
T5044	2126-2130	IN	denotes	that
T5046	2131-2134	DT	denotes	the
T5048	2135-2138	NN	denotes	sex
T5049	2139-2142	CC	denotes	and
T5050	2143-2146	NN	denotes	sex
T5052	2146-2147	HYPH	denotes	-
T5051	2147-2158	NN	denotes	interaction
T5047	2159-2164	NNS	denotes	terms
T5045	2165-2168	VBP	denotes	add
T5053	2169-2182	RB	denotes	significantly
T5054	2183-2185	IN	denotes	to
T5055	2186-2189	DT	denotes	the
T5056	2190-2199	NN	denotes	detection
T5057	2200-2202	IN	denotes	of
T5058	2203-2206	NN	denotes	QTL
T5059	2207-2210	IN	denotes	for
T5060	2211-2214	DT	denotes	the
T5062	2215-2219	NN	denotes	gene
T5063	2220-2230	NN	denotes	expression
T5061	2231-2237	NNS	denotes	traits
T5064	2237-2238	.	denotes	.
T5065	2238-2479	sentence	denotes	Using previously described conventions [20], QTL models without the final two interaction terms (sexadd and sexdom) have a suggestive threshold of 3.0 (p < 1 × 10−3) and a significant threshold of 4.3 (p < 5 × 10−5, genome-wide p < 0.05).
T5066	2239-2244	VBG	denotes	Using
T5068	2245-2255	RB	denotes	previously
T5069	2256-2265	VBN	denotes	described
T5070	2266-2277	NNS	denotes	conventions
T5071	2278-2279	-LRB-	denotes	[
T5072	2279-2281	CD	denotes	20
T5073	2281-2282	-RRB-	denotes	]
T5074	2282-2284	,	denotes	,
T5075	2284-2287	NN	denotes	QTL
T5076	2288-2294	NNS	denotes	models
T5077	2295-2302	IN	denotes	without
T5078	2303-2306	DT	denotes	the
T5080	2307-2312	JJ	denotes	final
T5081	2313-2316	CD	denotes	two
T5082	2317-2328	NN	denotes	interaction
T5079	2329-2334	NNS	denotes	terms
T5083	2335-2336	-LRB-	denotes	(
T5084	2336-2339	NN	denotes	sex
T5086	2339-2340	SYM	denotes	*
T5085	2340-2343	NN	denotes	add
T5087	2344-2347	CC	denotes	and
T5088	2348-2351	NN	denotes	sex
T5090	2351-2352	SYM	denotes	*
T5089	2352-2355	NN	denotes	dom
T5091	2355-2356	-RRB-	denotes	)
T5067	2357-2361	VBP	denotes	have
T5092	2362-2363	DT	denotes	a
T5094	2364-2374	JJ	denotes	suggestive
T5093	2375-2384	NN	denotes	threshold
T5095	2385-2387	IN	denotes	of
T5096	2388-2391	CD	denotes	3.0
T5097	2392-2393	-LRB-	denotes	(
T5099	2393-2394	NN	denotes	p
T5100	2395-2396	SYM	denotes	<
T5098	2397-2398	CD	denotes	1
T5101	2399-2400	SYM	denotes	×
T5102	2401-2403	CD	denotes	10
T5104	2403-2404	SYM	denotes	−
T5103	2404-2405	CD	denotes	3
T5105	2405-2406	-RRB-	denotes	)
T5106	2407-2410	CC	denotes	and
T5107	2411-2412	DT	denotes	a
T5109	2413-2424	JJ	denotes	significant
T5108	2425-2434	NN	denotes	threshold
T5110	2435-2437	IN	denotes	of
T5111	2438-2441	CD	denotes	4.3
T5112	2442-2443	-LRB-	denotes	(
T5114	2443-2444	NN	denotes	p
T5116	2445-2446	SYM	denotes	<
T5115	2447-2448	CD	denotes	5
T5117	2449-2450	SYM	denotes	×
T5118	2451-2453	CD	denotes	10
T5120	2453-2454	SYM	denotes	−
T5119	2454-2455	CD	denotes	5
T5121	2455-2457	,	denotes	,
T5122	2457-2463	NN	denotes	genome
T5124	2463-2464	HYPH	denotes	-
T5123	2464-2468	JJ	denotes	wide
T5125	2469-2470	NN	denotes	p
T5126	2471-2472	SYM	denotes	<
T5113	2473-2477	CD	denotes	0.05
T5127	2477-2478	-RRB-	denotes	)
T5128	2478-2479	.	denotes	.
T5129	2479-2774	sentence	denotes	QTL models incorporating only the sex*add interaction term in addition to the additive terms have one extra degree of freedom that leads to a corresponding increase in the LOD score thresholds to 3.5 (suggestive) and 4.9 (significant) for the 0.001 and 0.00005 p-value thresholds, respectively.
T5130	2480-2483	NN	denotes	QTL
T5131	2484-2490	NNS	denotes	models
T5133	2491-2504	VBG	denotes	incorporating
T5134	2505-2509	RB	denotes	only
T5135	2510-2513	DT	denotes	the
T5137	2514-2517	NN	denotes	sex
T5139	2517-2518	SYM	denotes	*
T5138	2518-2521	NN	denotes	add
T5140	2522-2533	NN	denotes	interaction
T5136	2534-2538	NN	denotes	term
T5141	2539-2541	IN	denotes	in
T5142	2542-2550	NN	denotes	addition
T5143	2551-2553	IN	denotes	to
T5144	2554-2557	DT	denotes	the
T5146	2558-2566	JJ	denotes	additive
T5145	2567-2572	NNS	denotes	terms
T5132	2573-2577	VBP	denotes	have
T5147	2578-2581	CD	denotes	one
T5149	2582-2587	JJ	denotes	extra
T5148	2588-2594	NN	denotes	degree
T5150	2595-2597	IN	denotes	of
T5151	2598-2605	NN	denotes	freedom
T5152	2606-2610	WDT	denotes	that
T5153	2611-2616	VBZ	denotes	leads
T5154	2617-2619	IN	denotes	to
T5155	2620-2621	DT	denotes	a
T5157	2622-2635	VBG	denotes	corresponding
T5156	2636-2644	NN	denotes	increase
T5158	2645-2647	IN	denotes	in
T5159	2648-2651	DT	denotes	the
T5161	2652-2655	NN	denotes	LOD
T5162	2656-2661	NN	denotes	score
T5160	2662-2672	NNS	denotes	thresholds
T5163	2673-2675	IN	denotes	to
T5164	2676-2679	CD	denotes	3.5
T5165	2680-2681	-LRB-	denotes	(
T5166	2681-2691	JJ	denotes	suggestive
T5167	2691-2692	-RRB-	denotes	)
T5168	2693-2696	CC	denotes	and
T5169	2697-2700	CD	denotes	4.9
T5170	2701-2702	-LRB-	denotes	(
T5171	2702-2713	JJ	denotes	significant
T5172	2713-2714	-RRB-	denotes	)
T5173	2715-2718	IN	denotes	for
T5174	2719-2722	DT	denotes	the
T5176	2723-2728	CD	denotes	0.001
T5177	2729-2732	CC	denotes	and
T5178	2733-2740	CD	denotes	0.00005
T5179	2741-2742	NN	denotes	p
T5181	2742-2743	HYPH	denotes	-
T5180	2743-2748	NN	denotes	value
T5175	2749-2759	NNS	denotes	thresholds
T5182	2759-2761	,	denotes	,
T5183	2761-2773	RB	denotes	respectively
T5184	2773-2774	.	denotes	.
T5185	2774-3036	sentence	denotes	QTL models incorporating both sexadd and sexdom interaction terms possess two extra degrees of freedom, with a corresponding increase in LOD score thresholds to 4.0 (suggestive) and 5.4 (significant) for the 0.001 and 0.00005 p-value thresholds, respectively.
T5186	2775-2778	NN	denotes	QTL
T5187	2779-2785	NNS	denotes	models
T5189	2786-2799	VBG	denotes	incorporating
T5190	2800-2804	CC	denotes	both
T5192	2805-2808	NN	denotes	sex
T5193	2808-2809	SYM	denotes	*
T5191	2809-2812	NN	denotes	add
T5195	2813-2816	CC	denotes	and
T5196	2817-2820	NN	denotes	sex
T5198	2820-2821	SYM	denotes	*
T5197	2821-2824	NN	denotes	dom
T5199	2825-2836	NN	denotes	interaction
T5194	2837-2842	NNS	denotes	terms
T5188	2843-2850	VBP	denotes	possess
T5200	2851-2854	CD	denotes	two
T5202	2855-2860	JJ	denotes	extra
T5201	2861-2868	NNS	denotes	degrees
T5203	2869-2871	IN	denotes	of
T5204	2872-2879	NN	denotes	freedom
T5205	2879-2881	,	denotes	,
T5206	2881-2885	IN	denotes	with
T5207	2886-2887	DT	denotes	a
T5209	2888-2901	VBG	denotes	corresponding
T5208	2902-2910	NN	denotes	increase
T5210	2911-2913	IN	denotes	in
T5211	2914-2917	NN	denotes	LOD
T5213	2918-2923	NN	denotes	score
T5212	2924-2934	NNS	denotes	thresholds
T5214	2935-2937	IN	denotes	to
T5215	2938-2941	CD	denotes	4.0
T5216	2942-2943	-LRB-	denotes	(
T5217	2943-2953	JJ	denotes	suggestive
T5218	2953-2954	-RRB-	denotes	)
T5219	2955-2958	CC	denotes	and
T5220	2959-2962	CD	denotes	5.4
T5221	2963-2964	-LRB-	denotes	(
T5222	2964-2975	JJ	denotes	significant
T5223	2975-2976	-RRB-	denotes	)
T5224	2977-2980	IN	denotes	for
T5225	2981-2984	DT	denotes	the
T5227	2985-2990	CD	denotes	0.001
T5228	2991-2994	CC	denotes	and
T5229	2995-3002	CD	denotes	0.00005
T5230	3003-3004	NN	denotes	p
T5232	3004-3005	HYPH	denotes	-
T5231	3005-3010	NN	denotes	value
T5226	3011-3021	NNS	denotes	thresholds
T5233	3021-3023	,	denotes	,
T5234	3023-3035	RB	denotes	respectively
T5235	3035-3036	.	denotes	.
T5236	3036-3193	sentence	denotes	One suggestive (Chromosome 1) and four significant (Chromosomes 3, 5, 11, and 19) cQTLs for the gonadal fat mass trait were identified (Figure 1A; Table 2).
T5237	3037-3040	CD	denotes	One
T5238	3041-3051	JJ	denotes	suggestive
T5240	3052-3053	-LRB-	denotes	(
T5241	3053-3063	NN	denotes	Chromosome
T5242	3064-3065	CD	denotes	1
T5243	3065-3066	-RRB-	denotes	)
T5244	3067-3070	CC	denotes	and
T5245	3071-3075	CD	denotes	four
T5246	3076-3087	JJ	denotes	significant
T5247	3088-3089	-LRB-	denotes	(
T5249	3089-3100	NNS	denotes	Chromosomes
T5248	3101-3102	CD	denotes	3
T5250	3102-3104	,	denotes	,
T5251	3104-3105	CD	denotes	5
T5252	3105-3107	,	denotes	,
T5253	3107-3109	CD	denotes	11
T5254	3109-3111	,	denotes	,
T5255	3111-3114	CC	denotes	and
T5256	3115-3117	CD	denotes	19
T5257	3117-3118	-RRB-	denotes	)
T5239	3119-3124	NNS	denotes	cQTLs
T5259	3125-3128	IN	denotes	for
T5260	3129-3132	DT	denotes	the
T5262	3133-3140	JJ	denotes	gonadal
T5264	3141-3144	NN	denotes	fat
T5263	3145-3149	NN	denotes	mass
T5261	3150-3155	NN	denotes	trait
T5265	3156-3160	VBD	denotes	were
T5258	3161-3171	VBN	denotes	identified
T5266	3172-3173	-LRB-	denotes	(
T5268	3173-3179	NN	denotes	Figure
T5269	3180-3182	NN	denotes	1A
T5270	3182-3183	:	denotes	;
T5267	3184-3189	NN	denotes	Table
T5271	3190-3191	CD	denotes	2
T5272	3191-3192	-RRB-	denotes	)
T5273	3192-3193	.	denotes	.
T5274	3193-3399	sentence	denotes	Four out of the five cQTLs showed statistically significant better fits with the full model incorporating the interaction terms sexadd and sexdom, compared to the model including only the additive terms.
T5275	3194-3198	CD	denotes	Four
T5277	3199-3202	IN	denotes	out
T5278	3203-3205	IN	denotes	of
T5279	3206-3209	DT	denotes	the
T5276	3210-3214	CD	denotes	five
T5280	3215-3220	NNS	denotes	cQTLs
T5281	3221-3227	VBD	denotes	showed
T5282	3228-3241	RB	denotes	statistically
T5283	3242-3253	JJ	denotes	significant
T5285	3254-3260	JJR	denotes	better
T5284	3261-3265	NNS	denotes	fits
T5286	3266-3270	IN	denotes	with
T5287	3271-3274	DT	denotes	the
T5289	3275-3279	JJ	denotes	full
T5288	3280-3285	NN	denotes	model
T5290	3286-3299	VBG	denotes	incorporating
T5291	3300-3303	DT	denotes	the
T5293	3304-3315	NN	denotes	interaction
T5292	3316-3321	NNS	denotes	terms
T5294	3322-3325	NN	denotes	sex
T5295	3325-3326	SYM	denotes	*
T5296	3326-3329	NN	denotes	add
T5297	3330-3333	CC	denotes	and
T5298	3334-3337	NN	denotes	sex
T5299	3337-3338	SYM	denotes	*
T5300	3338-3341	NN	denotes	dom
T5301	3341-3343	,	denotes	,
T5302	3343-3351	VBN	denotes	compared
T5303	3352-3354	IN	denotes	to
T5304	3355-3358	DT	denotes	the
T5305	3359-3364	NN	denotes	model
T5306	3365-3374	VBG	denotes	including
T5307	3375-3379	RB	denotes	only
T5309	3380-3383	DT	denotes	the
T5310	3384-3392	JJ	denotes	additive
T5308	3393-3398	NNS	denotes	terms
T5311	3398-3399	.	denotes	.
T5312	3399-3552	sentence	denotes	Interestingly, the cQTL over Chromosome 11 did not improve, suggesting that the additional terms did not contribute to improved detection of this locus.
T5313	3400-3413	RB	denotes	Interestingly
T5315	3413-3415	,	denotes	,
T5316	3415-3418	DT	denotes	the
T5317	3419-3423	NN	denotes	cQTL
T5318	3424-3428	IN	denotes	over
T5319	3429-3439	NN	denotes	Chromosome
T5320	3440-3442	CD	denotes	11
T5321	3443-3446	VBD	denotes	did
T5322	3447-3450	RB	denotes	not
T5314	3451-3458	VB	denotes	improve
T5323	3458-3460	,	denotes	,
T5324	3460-3470	VBG	denotes	suggesting
T5325	3471-3475	IN	denotes	that
T5327	3476-3479	DT	denotes	the
T5329	3480-3490	JJ	denotes	additional
T5328	3491-3496	NNS	denotes	terms
T5330	3497-3500	VBD	denotes	did
T5331	3501-3504	RB	denotes	not
T5326	3505-3515	VB	denotes	contribute
T5332	3516-3518	IN	denotes	to
T5333	3519-3527	VBN	denotes	improved
T5334	3528-3537	NN	denotes	detection
T5335	3538-3540	IN	denotes	of
T5336	3541-3545	DT	denotes	this
T5337	3546-3551	NN	denotes	locus
T5338	3551-3552	.	denotes	.
T5339	3552-3632	sentence	denotes	Table 2 summarizes the position and LOD score of maximal linkage for each cQTL.
T5340	3553-3558	NN	denotes	Table
T5342	3559-3560	CD	denotes	2
T5341	3561-3571	VBZ	denotes	summarizes
T5343	3572-3575	DT	denotes	the
T5344	3576-3584	NN	denotes	position
T5345	3585-3588	CC	denotes	and
T5346	3589-3592	NN	denotes	LOD
T5347	3593-3598	NN	denotes	score
T5348	3599-3601	IN	denotes	of
T5349	3602-3609	JJ	denotes	maximal
T5350	3610-3617	NN	denotes	linkage
T5351	3618-3621	IN	denotes	for
T5352	3622-3626	DT	denotes	each
T5353	3627-3631	NN	denotes	cQTL
T5354	3631-3632	.	denotes	.
T5355	3632-3858	sentence	denotes	While the focus of this study was the gonadal fat mass trait, it is noted that a genome scan for the adiposity trait resulted in cQTLs at the same locations, with very similar LOD scores and sex dependence (unpublished data).
T5356	3633-3638	IN	denotes	While
T5358	3639-3642	DT	denotes	the
T5359	3643-3648	NN	denotes	focus
T5360	3649-3651	IN	denotes	of
T5361	3652-3656	DT	denotes	this
T5362	3657-3662	NN	denotes	study
T5357	3663-3666	VBD	denotes	was
T5364	3667-3670	DT	denotes	the
T5366	3671-3678	JJ	denotes	gonadal
T5368	3679-3682	NN	denotes	fat
T5367	3683-3687	NN	denotes	mass
T5365	3688-3693	NN	denotes	trait
T5369	3693-3695	,	denotes	,
T5370	3695-3697	PRP	denotes	it
T5371	3698-3700	VBZ	denotes	is
T5363	3701-3706	VBN	denotes	noted
T5372	3707-3711	IN	denotes	that
T5374	3712-3713	DT	denotes	a
T5376	3714-3720	NN	denotes	genome
T5375	3721-3725	NN	denotes	scan
T5377	3726-3729	IN	denotes	for
T5378	3730-3733	DT	denotes	the
T5380	3734-3743	NN	denotes	adiposity
T5379	3744-3749	NN	denotes	trait
T5373	3750-3758	VBD	denotes	resulted
T5381	3759-3761	IN	denotes	in
T5382	3762-3767	NNS	denotes	cQTLs
T5383	3768-3770	IN	denotes	at
T5384	3771-3774	DT	denotes	the
T5386	3775-3779	JJ	denotes	same
T5385	3780-3789	NNS	denotes	locations
T5387	3789-3791	,	denotes	,
T5388	3791-3795	IN	denotes	with
T5389	3796-3800	RB	denotes	very
T5390	3801-3808	JJ	denotes	similar
T5392	3809-3812	NN	denotes	LOD
T5391	3813-3819	NNS	denotes	scores
T5393	3820-3823	CC	denotes	and
T5394	3824-3827	NN	denotes	sex
T5395	3828-3838	NN	denotes	dependence
T5396	3839-3840	-LRB-	denotes	(
T5398	3840-3851	JJ	denotes	unpublished
T5397	3852-3856	NNS	denotes	data
T5399	3856-3857	-RRB-	denotes	)
T5400	3857-3858	.	denotes	.
T5401	3858-5175	sentence	denotes	Figure 1 Genome Scan for Gonadal Fat Mass (A) Animals were genotyped at an average 1.5 cM density using 1,032 SNPs polymorphic between the parental strains. LOD scores computed using sex as an additive covariate (black) failed to detect significant linkage. A genome scan accounting for interactions between sex and QTL (red) showed evidence for suggestive linkage on Chromosome 1 and significant linkage on Chromosomes 3, 5, 11, and 19. Dashed and solid lines are thresholds for suggestive (p < 1 × 10−3) and significant linkage (p < 5 × 10−5), respectively. (B) Genome scans for gonadal fat mass using different models over mouse Chromosome 5. Scans for fat mass using all animals with (black) and without (green) sex as an additive covariate failed to detect significant linkage. Females analyzed alone (magenta) showed evidence for suggestive linkage (p < 2 × 10−4). When both sexes were analyzed to account for sex effects (red), a significant QTL was realized (p < 10−6). For clarity, only the model incorporating both the “sexadd” and “sexdom” terms is shown in red, although additional models incorporating the terms separately were also computed. Table 2 cQTLs for Gonadal Fat Mass Results from the various regression models used to determine linkage for the Chromosome 5 cQTL are depicted in Figure 1B.
T5402	5054-5061	NNS	denotes	Results
T5404	5062-5066	IN	denotes	from
T5405	5067-5070	DT	denotes	the
T5407	5071-5078	JJ	denotes	various
T5408	5079-5089	NN	denotes	regression
T5406	5090-5096	NNS	denotes	models
T5409	5097-5101	VBN	denotes	used
T5410	5102-5104	TO	denotes	to
T5411	5105-5114	VB	denotes	determine
T5412	5115-5122	NN	denotes	linkage
T5413	5123-5126	IN	denotes	for
T5414	5127-5130	DT	denotes	the
T5416	5131-5141	NN	denotes	Chromosome
T5417	5142-5143	CD	denotes	5
T5415	5144-5148	NN	denotes	cQTL
T5418	5149-5152	VBP	denotes	are
T5403	5153-5161	VBN	denotes	depicted
T5419	5162-5164	IN	denotes	in
T5420	5165-5171	NN	denotes	Figure
T5421	5172-5174	NN	denotes	1B
T5422	5174-5175	.	denotes	.
T5423	5175-5294	sentence	denotes	Analysis of all animals with and without sex as a covariate failed to demonstrate evidence of linkage on Chromosome 5.
T5424	5176-5184	NN	denotes	Analysis
T5426	5185-5187	IN	denotes	of
T5427	5188-5191	DT	denotes	all
T5428	5192-5199	NNS	denotes	animals
T5429	5200-5204	IN	denotes	with
T5430	5205-5208	CC	denotes	and
T5431	5209-5216	IN	denotes	without
T5432	5217-5220	NN	denotes	sex
T5433	5221-5223	IN	denotes	as
T5434	5224-5225	DT	denotes	a
T5435	5226-5235	NN	denotes	covariate
T5425	5236-5242	VBD	denotes	failed
T5436	5243-5245	TO	denotes	to
T5437	5246-5257	VB	denotes	demonstrate
T5438	5258-5266	NN	denotes	evidence
T5439	5267-5269	IN	denotes	of
T5440	5270-5277	NN	denotes	linkage
T5441	5278-5280	IN	denotes	on
T5442	5281-5291	NN	denotes	Chromosome
T5443	5292-5293	CD	denotes	5
T5444	5293-5294	.	denotes	.
T5445	5294-5450	sentence	denotes	When females were analyzed alone, a suggestive LOD score of 3.7 was realized (p = 2 × 10−4); males analyzed alone did not demonstrate evidence for linkage.
T5446	5295-5299	WRB	denotes	When
T5448	5300-5307	NNS	denotes	females
T5449	5308-5312	VBD	denotes	were
T5447	5313-5321	VBN	denotes	analyzed
T5451	5322-5327	RB	denotes	alone
T5452	5327-5329	,	denotes	,
T5453	5329-5330	DT	denotes	a
T5455	5331-5341	JJ	denotes	suggestive
T5456	5342-5345	NN	denotes	LOD
T5454	5346-5351	NN	denotes	score
T5457	5352-5354	IN	denotes	of
T5458	5355-5358	CD	denotes	3.7
T5459	5359-5362	VBD	denotes	was
T5450	5363-5371	VBN	denotes	realized
T5461	5372-5373	-LRB-	denotes	(
T5463	5373-5374	NN	denotes	p
T5464	5375-5376	SYM	denotes	=
T5462	5377-5378	CD	denotes	2
T5465	5379-5380	SYM	denotes	×
T5466	5381-5383	CD	denotes	10
T5468	5383-5384	SYM	denotes	−
T5467	5384-5385	CD	denotes	4
T5469	5385-5386	-RRB-	denotes	)
T5470	5386-5387	:	denotes	;
T5471	5388-5393	NNS	denotes	males
T5472	5394-5402	VBN	denotes	analyzed
T5473	5403-5408	RB	denotes	alone
T5474	5409-5412	VBD	denotes	did
T5475	5413-5416	RB	denotes	not
T5460	5417-5428	VB	denotes	demonstrate
T5476	5429-5437	NN	denotes	evidence
T5477	5438-5441	IN	denotes	for
T5478	5442-5449	NN	denotes	linkage
T5479	5449-5450	.	denotes	.
T5480	5450-5636	sentence	denotes	However, using all 334 animals and adding the interaction terms to the QTL model significantly improved sensitivity, and a cQTL with a maximum LOD of 7.56 (p = 1.7 × 10−6) was realized.
T5481	5451-5458	RB	denotes	However
T5483	5458-5460	,	denotes	,
T5484	5460-5465	VBG	denotes	using
T5485	5466-5469	DT	denotes	all
T5487	5470-5473	CD	denotes	334
T5486	5474-5481	NNS	denotes	animals
T5488	5482-5485	CC	denotes	and
T5489	5486-5492	VBG	denotes	adding
T5490	5493-5496	DT	denotes	the
T5492	5497-5508	NN	denotes	interaction
T5491	5509-5514	NNS	denotes	terms
T5493	5515-5517	IN	denotes	to
T5494	5518-5521	DT	denotes	the
T5496	5522-5525	NN	denotes	QTL
T5495	5526-5531	NN	denotes	model
T5497	5532-5545	RB	denotes	significantly
T5482	5546-5554	VBD	denotes	improved
T5498	5555-5566	NN	denotes	sensitivity
T5499	5566-5568	,	denotes	,
T5500	5568-5571	CC	denotes	and
T5501	5572-5573	DT	denotes	a
T5502	5574-5578	NN	denotes	cQTL
T5504	5579-5583	IN	denotes	with
T5505	5584-5585	DT	denotes	a
T5507	5586-5593	NN	denotes	maximum
T5506	5594-5597	NN	denotes	LOD
T5508	5598-5600	IN	denotes	of
T5509	5601-5605	CD	denotes	7.56
T5510	5606-5607	-LRB-	denotes	(
T5512	5607-5608	NN	denotes	p
T5513	5609-5610	SYM	denotes	=
T5511	5611-5614	CD	denotes	1.7
T5514	5615-5616	SYM	denotes	×
T5515	5617-5619	CD	denotes	10
T5517	5619-5620	SYM	denotes	−
T5516	5620-5621	CD	denotes	6
T5518	5621-5622	-RRB-	denotes	)
T5519	5623-5626	VBD	denotes	was
T5503	5627-5635	VBN	denotes	realized
T5520	5635-5636	.	denotes	.
T5521	5636-5895	sentence	denotes	Given the improved detection of four of the five cQTLs when sex-additive and sex-dominant interaction terms were considered, we hypothesized that the main genotype effect of these cQTLs on the gonadal fat mass trait would differ between the sexes (Figure 2).
T5522	5637-5642	VBN	denotes	Given
T5524	5643-5646	DT	denotes	the
T5526	5647-5655	VBN	denotes	improved
T5525	5656-5665	NN	denotes	detection
T5527	5666-5668	IN	denotes	of
T5528	5669-5673	CD	denotes	four
T5530	5674-5676	IN	denotes	of
T5531	5677-5680	DT	denotes	the
T5529	5681-5685	CD	denotes	five
T5532	5686-5691	NNS	denotes	cQTLs
T5533	5692-5696	WRB	denotes	when
T5535	5697-5700	NN	denotes	sex
T5537	5700-5701	HYPH	denotes	-
T5536	5701-5709	JJ	denotes	additive
T5539	5710-5713	CC	denotes	and
T5540	5714-5717	NN	denotes	sex
T5542	5717-5718	HYPH	denotes	-
T5541	5718-5726	JJ	denotes	dominant
T5543	5727-5738	NN	denotes	interaction
T5538	5739-5744	NNS	denotes	terms
T5544	5745-5749	VBD	denotes	were
T5534	5750-5760	VBN	denotes	considered
T5545	5760-5762	,	denotes	,
T5546	5762-5764	PRP	denotes	we
T5523	5765-5777	VBD	denotes	hypothesized
T5547	5778-5782	IN	denotes	that
T5549	5783-5786	DT	denotes	the
T5551	5787-5791	JJ	denotes	main
T5552	5792-5800	NN	denotes	genotype
T5550	5801-5807	NN	denotes	effect
T5553	5808-5810	IN	denotes	of
T5554	5811-5816	DT	denotes	these
T5555	5817-5822	NNS	denotes	cQTLs
T5556	5823-5825	IN	denotes	on
T5557	5826-5829	DT	denotes	the
T5559	5830-5837	JJ	denotes	gonadal
T5561	5838-5841	NN	denotes	fat
T5560	5842-5846	NN	denotes	mass
T5558	5847-5852	NN	denotes	trait
T5562	5853-5858	MD	denotes	would
T5548	5859-5865	VB	denotes	differ
T5563	5866-5873	IN	denotes	between
T5564	5874-5877	DT	denotes	the
T5565	5878-5883	NNS	denotes	sexes
T5566	5884-5885	-LRB-	denotes	(
T5567	5885-5891	NN	denotes	Figure
T5568	5892-5893	CD	denotes	2
T5569	5893-5894	-RRB-	denotes	)
T5570	5894-5895	.	denotes	.
T5571	5895-6000	sentence	denotes	Indeed, cQTLs located on Chromosomes 1, 3, and 5 showed opposing effects on fat mass, or sex antagonism.
T5572	5896-5902	RB	denotes	Indeed
T5574	5902-5904	,	denotes	,
T5575	5904-5909	NNS	denotes	cQTLs
T5576	5910-5917	VBN	denotes	located
T5577	5918-5920	IN	denotes	on
T5578	5921-5932	NNS	denotes	Chromosomes
T5579	5933-5934	CD	denotes	1
T5580	5934-5936	,	denotes	,
T5581	5936-5937	CD	denotes	3
T5582	5937-5939	,	denotes	,
T5583	5939-5942	CC	denotes	and
T5584	5943-5944	CD	denotes	5
T5573	5945-5951	VBD	denotes	showed
T5585	5952-5960	VBG	denotes	opposing
T5586	5961-5968	NNS	denotes	effects
T5587	5969-5971	IN	denotes	on
T5588	5972-5975	NN	denotes	fat
T5589	5976-5980	NN	denotes	mass
T5590	5980-5982	,	denotes	,
T5591	5982-5984	CC	denotes	or
T5592	5985-5988	NN	denotes	sex
T5593	5989-5999	NN	denotes	antagonism
T5594	5999-6000	.	denotes	.
T5595	6000-6253	sentence	denotes	The effect of the cQTL on Chromosome 11 was in the same direction in both males and females, but was sex-biased toward a larger effect in females (R 2 = 0.091 in females versus R 2 = 0.046 in males), confirming the minimal sex specificity of this cQTL.
T5596	6001-6004	DT	denotes	The
T5597	6005-6011	NN	denotes	effect
T5599	6012-6014	IN	denotes	of
T5600	6015-6018	DT	denotes	the
T5601	6019-6023	NN	denotes	cQTL
T5602	6024-6026	IN	denotes	on
T5603	6027-6037	NN	denotes	Chromosome
T5604	6038-6040	CD	denotes	11
T5598	6041-6044	VBD	denotes	was
T5605	6045-6047	IN	denotes	in
T5606	6048-6051	DT	denotes	the
T5608	6052-6056	JJ	denotes	same
T5607	6057-6066	NN	denotes	direction
T5609	6067-6069	IN	denotes	in
T5610	6070-6074	CC	denotes	both
T5611	6075-6080	NNS	denotes	males
T5612	6081-6084	CC	denotes	and
T5613	6085-6092	NNS	denotes	females
T5614	6092-6094	,	denotes	,
T5615	6094-6097	CC	denotes	but
T5616	6098-6101	VBD	denotes	was
T5618	6102-6105	NN	denotes	sex
T5619	6105-6106	HYPH	denotes	-
T5617	6106-6112	VBN	denotes	biased
T5620	6113-6119	IN	denotes	toward
T5621	6120-6121	DT	denotes	a
T5623	6122-6128	JJR	denotes	larger
T5622	6129-6135	NN	denotes	effect
T5624	6136-6138	IN	denotes	in
T5625	6139-6146	NNS	denotes	females
T5626	6147-6148	-LRB-	denotes	(
T5628	6148-6151	NN	denotes	R 2
T5629	6152-6153	SYM	denotes	=
T5627	6154-6159	CD	denotes	0.091
T5630	6160-6162	IN	denotes	in
T5631	6163-6170	NNS	denotes	females
T5632	6171-6177	CC	denotes	versus
T5633	6178-6181	NN	denotes	R 2
T5635	6182-6183	SYM	denotes	=
T5634	6184-6189	CD	denotes	0.046
T5636	6190-6192	IN	denotes	in
T5637	6193-6198	NNS	denotes	males
T5638	6198-6199	-RRB-	denotes	)
T5639	6199-6201	,	denotes	,
T5640	6201-6211	VBG	denotes	confirming
T5641	6212-6215	DT	denotes	the
T5643	6216-6223	JJ	denotes	minimal
T5644	6224-6227	NN	denotes	sex
T5642	6228-6239	NN	denotes	specificity
T5645	6240-6242	IN	denotes	of
T5646	6243-6247	DT	denotes	this
T5647	6248-6252	NN	denotes	cQTL
T5648	6252-6253	.	denotes	.
T5649	6253-6345	sentence	denotes	The cQTL on Chromosome 19 showed a sex-specific effect in females, with no effect in males.
T5650	6254-6257	DT	denotes	The
T5651	6258-6262	NN	denotes	cQTL
T5653	6263-6265	IN	denotes	on
T5654	6266-6276	NN	denotes	Chromosome
T5655	6277-6279	CD	denotes	19
T5652	6280-6286	VBD	denotes	showed
T5656	6287-6288	DT	denotes	a
T5658	6289-6292	NN	denotes	sex
T5660	6292-6293	HYPH	denotes	-
T5659	6293-6301	JJ	denotes	specific
T5657	6302-6308	NN	denotes	effect
T5661	6309-6311	IN	denotes	in
T5662	6312-6319	NNS	denotes	females
T5663	6319-6321	,	denotes	,
T5664	6321-6325	IN	denotes	with
T5665	6326-6328	DT	denotes	no
T5666	6329-6335	NN	denotes	effect
T5667	6336-6338	IN	denotes	in
T5668	6339-6344	NNS	denotes	males
T5669	6344-6345	.	denotes	.
T5670	6345-6789	sentence	denotes	Figure 2 Effect of Genotype on Fat Mass Homozygous B6 (BB), C3H (CC), or heterozygous (BC) genotype at all five QTL positions, separated by sex, are shown. The underlying genotypic effects of the QTLs on fat mass differ between the sexes. Coefficients of determination (R 2) are shown along with associated ANOVAs p < 0.05, p < 0.01, **p < 0.001. Overall, all five cQTLs for gonadal fat mass were biased toward a larger effect in females.
T5671	6698-6705	RB	denotes	Overall
T5673	6705-6707	,	denotes	,
T5674	6707-6710	DT	denotes	all
T5676	6711-6715	CD	denotes	five
T5675	6716-6721	NNS	denotes	cQTLs
T5677	6722-6725	IN	denotes	for
T5678	6726-6733	JJ	denotes	gonadal
T5680	6734-6737	NN	denotes	fat
T5679	6738-6742	NN	denotes	mass
T5672	6743-6747	VBD	denotes	were
T5681	6748-6754	JJ	denotes	biased
T5682	6755-6761	IN	denotes	toward
T5683	6762-6763	DT	denotes	a
T5685	6764-6770	JJR	denotes	larger
T5684	6771-6777	NN	denotes	effect
T5686	6778-6780	IN	denotes	in
T5687	6781-6788	NNS	denotes	females
T5688	6788-6789	.	denotes	.
T5689	6789-7133	sentence	denotes	Assuming purely additive effects of each genotype, these cQTLs account for approximately 42% of the variation in female F2 mice and 13% in males, consistent with the narrow sense heritability estimates for this trait and again demonstrating significant differences in the regulation and heritability of the gonadal fat trait between the sexes.
T5690	6790-6798	VBG	denotes	Assuming
T5692	6799-6805	RB	denotes	purely
T5693	6806-6814	JJ	denotes	additive
T5694	6815-6822	NNS	denotes	effects
T5695	6823-6825	IN	denotes	of
T5696	6826-6830	DT	denotes	each
T5697	6831-6839	NN	denotes	genotype
T5698	6839-6841	,	denotes	,
T5699	6841-6846	DT	denotes	these
T5700	6847-6852	NNS	denotes	cQTLs
T5691	6853-6860	VBP	denotes	account
T5701	6861-6864	IN	denotes	for
T5702	6865-6878	RB	denotes	approximately
T5703	6879-6881	CD	denotes	42
T5704	6881-6882	NN	denotes	%
T5705	6883-6885	IN	denotes	of
T5706	6886-6889	DT	denotes	the
T5707	6890-6899	NN	denotes	variation
T5708	6900-6902	IN	denotes	in
T5709	6903-6909	JJ	denotes	female
T5711	6910-6912	NN	denotes	F2
T5710	6913-6917	NNS	denotes	mice
T5712	6918-6921	CC	denotes	and
T5713	6922-6924	CD	denotes	13
T5714	6924-6925	NN	denotes	%
T5715	6926-6928	IN	denotes	in
T5716	6929-6934	NNS	denotes	males
T5717	6934-6936	,	denotes	,
T5718	6936-6946	JJ	denotes	consistent
T5719	6947-6951	IN	denotes	with
T5720	6952-6955	DT	denotes	the
T5722	6956-6962	JJ	denotes	narrow
T5723	6963-6968	NN	denotes	sense
T5724	6969-6981	NN	denotes	heritability
T5721	6982-6991	NNS	denotes	estimates
T5725	6992-6995	IN	denotes	for
T5726	6996-7000	DT	denotes	this
T5727	7001-7006	NN	denotes	trait
T5728	7007-7010	CC	denotes	and
T5729	7011-7016	RB	denotes	again
T5730	7017-7030	VBG	denotes	demonstrating
T5731	7031-7042	JJ	denotes	significant
T5732	7043-7054	NNS	denotes	differences
T5733	7055-7057	IN	denotes	in
T5734	7058-7061	DT	denotes	the
T5735	7062-7072	NN	denotes	regulation
T5736	7073-7076	CC	denotes	and
T5737	7077-7089	NN	denotes	heritability
T5738	7090-7092	IN	denotes	of
T5739	7093-7096	DT	denotes	the
T5741	7097-7104	JJ	denotes	gonadal
T5742	7105-7108	NN	denotes	fat
T5740	7109-7114	NN	denotes	trait
T5743	7115-7122	IN	denotes	between
T5744	7123-7126	DT	denotes	the
T5745	7127-7132	NNS	denotes	sexes
T5746	7132-7133	.	denotes	.
R1000	T4843	T4839	punct	],QTLs
R1001	T4844	T4839	punct	),QTLs
R1002	T4845	T4836	punct	", ",traits
R1003	T4846	T4836	prep	including,traits
R1004	T4847	T4848	det	the,values
R1005	T4848	T4846	pobj	values,including
R1006	T4849	T4848	amod	unadjusted,values
R1007	T4850	T4848	amod	raw,values
R1008	T4851	T4848	prep	for,values
R1009	T4852	T4853	amod	gonadal,mass
R1010	T4853	T4851	pobj	mass,for
R1011	T4854	T4853	compound	fat,mass
R1012	T4855	T4833	punct	", ",performed
R1013	T4856	T4833	auxpass	was,performed
R1014	T4857	T4833	advcl	using,performed
R1015	T4858	T4859	det	a,approach
R1016	T4859	T4857	dobj	approach,using
R1017	T4860	T4861	amod	single,marker
R1018	T4861	T4859	compound	marker,approach
R1019	T4862	T4859	compound	regression,approach
R1020	T4863	T4859	punct	(,approach
R1021	T4864	T4859	acl	justified,approach
R1022	T4865	T4864	agent	by,justified
R1023	T4866	T4867	det	the,density
R1024	T4867	T4865	pobj	density,by
R1025	T4868	T4867	compound	high,density
R1026	T4869	T4867	punct	-,density
R1027	T4870	T4867	prep	of,density
R1028	T4871	T4870	pobj	markers,of
R1029	T4872	T4867	punct	", ",density
R1030	T4873	T4867	acl	making,density
R1031	T4874	T4875	compound	interval,mapping
R1032	T4875	T4876	nsubj	mapping,unnecessary
R1033	T4876	T4873	ccomp	unnecessary,making
R1034	T4877	T4833	punct	),performed
R1035	T4878	T4833	punct	.,performed
R1036	T4880	T4881	prep	In,included
R1037	T4882	T4880	pobj	order,In
R1038	T4883	T4884	aux	to,test
R1039	T4884	T4882	acl	test,order
R1040	T4885	T4884	advmod	specifically,test
R1041	T4886	T4884	prep	for,test
R1042	T4887	T4888	compound	sex,effects
R1043	T4888	T4886	pobj	effects,for
R1044	T4889	T4888	prep	of,effects
R1045	T4890	T4889	pobj	linkage,of
R1046	T4891	T4881	punct	", ",included
R1047	T4892	T4881	nsubj	we,included
R1048	T4893	T4894	amod	additive,parameters
R1049	T4894	T4881	dobj	parameters,included
R1050	T4895	T4893	punct	", ",additive
R1051	T4896	T4893	conj	dominant,additive
R1052	T4897	T4896	punct	", ",dominant
R1053	T4898	T4896	conj	sex,dominant
R1054	T4909	T4910	poss	our,calculations
R1055	T4899	T4898	punct	", ",sex
R1056	T4910	T4908	pobj	calculations,in
R1057	T4911	T4912	punct	(,see
R1058	T4900	T4901	npadvmod	sex,additive
R1059	T4901	T4898	conj	additive,sex
R1060	T4912	T4881	parataxis	see,included
R1061	T4902	T4901	punct	-,additive
R1062	T4913	T4912	dobj	Materials,see
R1063	T4914	T4913	cc	and,Materials
R1064	T4903	T4901	punct	", ",additive
R1065	T4915	T4913	conj	Methods,Materials
R1066	T4904	T4901	cc	and,additive
R1067	T4916	T4912	punct	),see
R1068	T4905	T4906	npadvmod	sex,dominant
R1069	T4906	T4901	conj	dominant,additive
R1070	T4917	T4881	punct	.,included
R1071	T4907	T4906	punct	-,dominant
R1072	T4919	T4920	det	A,procedure
R1073	T4908	T4881	prep	in,included
R1074	T4920	T4923	nsubjpass	procedure,used
R1075	T4921	T4920	amod	stepwise,procedure
R1076	T4922	T4920	compound	regression,procedure
R1077	T5015	T5014	dobj	QTLs,detect
R1078	T4924	T4923	auxpass	was,used
R1079	T4925	T4926	aux	to,determine
R1080	T4926	T4923	advcl	determine,used
R1081	T4927	T4928	mark	whether,improved
R1082	T4928	T4926	ccomp	improved,determine
R1083	T4929	T4930	det	the,addition
R1084	T4930	T4928	nsubj	addition,improved
R1085	T4931	T4930	prep	of,addition
R1086	T5016	T5012	prep	compared,power
R1087	T4932	T4933	det	the,terms
R1088	T4933	T4931	pobj	terms,of
R1089	T4934	T4933	amod	final,terms
R1090	T5017	T5016	prep	to,compared
R1091	T4935	T4933	nummod	two,terms
R1092	T4936	T4928	advmod	significantly,improved
R1093	T5018	T5019	compound	QTL,methods
R1094	T4937	T4938	det	the,model
R1095	T4938	T4928	dobj	model,improved
R1096	T4939	T4940	amod	linear,regression
R1097	T5019	T5017	pobj	methods,to
R1098	T4940	T4938	compound	regression,model
R1099	T5020	T5019	compound	mapping,methods
R1100	T4941	T4928	punct	", ",improved
R1101	T4942	T4928	advcl	conditional,improved
R1102	T4943	T4942	prep	on,conditional
R1103	T4944	T4943	pcomp	realizing,on
R1104	T5021	T5022	dep	that,incorporate
R1105	T4945	T4946	det	a,effect
R1106	T4946	T4944	dobj	effect,realizing
R1107	T5022	T5019	relcl	incorporate,methods
R1108	T4947	T4946	amod	significant,effect
R1109	T4948	T4946	amod	additive,effect
R1110	T4949	T4946	compound	QTL,effect
R1111	T5023	T5022	aux	do,incorporate
R1112	T4950	T4923	punct	.,used
R1113	T4952	T4953	nsubj	We,performed
R1114	T5024	T5022	neg	not,incorporate
R1115	T4954	T4955	compound	permutation,analyses
R1116	T5025	T5022	dobj	sex,incorporate
R1117	T4955	T4953	dobj	analyses,performed
R1118	T4956	T4953	prep	over,performed
R1119	T5026	T5025	cc	and,sex
R1120	T4957	T4958	det	all,traits
R1121	T4958	T4956	pobj	traits,over
R1122	T4959	T4960	compound	gene,expression
R1123	T4960	T4958	compound	expression,traits
R1124	T4961	T4953	punct	", ",performed
R1125	T5027	T5028	compound	genotype,sex
R1126	T4962	T4953	advcl	estimating,performed
R1127	T4963	T4964	amod	false,rates
R1128	T4964	T4962	dobj	rates,estimating
R1129	T5028	T5030	compound	sex,interactions
R1130	T4965	T4964	compound	discovery,rates
R1131	T4966	T4964	punct	(,rates
R1132	T4967	T4964	appos	FDRs,rates
R1133	T5029	T5028	punct	–,sex
R1134	T4968	T4962	punct	),estimating
R1135	T4969	T4962	prep	at,estimating
R1136	T4970	T4971	amod	different,thresholds
R1137	T5030	T5025	conj	interactions,sex
R1138	T4971	T4969	pobj	thresholds,at
R1139	T4972	T4971	nmod	logarithm,thresholds
R1140	T4973	T4972	prep	of,logarithm
R1141	T5031	T5032	punct	(,S1
R1142	T4974	T4973	pobj	odds,of
R1143	T4975	T4972	punct	(,logarithm
R1144	T4976	T4972	appos	LOD,logarithm
R1145	T5032	T5006	parataxis	S1,has
R1146	T4977	T4971	punct	),thresholds
R1147	T4978	T4971	compound	score,thresholds
R1148	T4979	T4962	cc	and,estimating
R1149	T5033	T5032	compound	Figure,S1
R1150	T4980	T4962	conj	assessing,estimating
R1151	T4981	T4982	det	the,rate
R1152	T5034	T5032	punct	),S1
R1153	T4982	T4980	dobj	rate,assessing
R1154	T4983	T4982	amod	overall,rate
R1155	T4984	T4982	prep	of,rate
R1156	T5035	T4990	punct	.,constructed
R1157	T4985	T4986	compound	QTL,detection
R1158	T4986	T4984	pobj	detection,of
R1159	T4987	T4953	punct	.,performed
R1160	T5037	T5038	nsubj	It,is
R1161	T4989	T4990	prep	From,constructed
R1162	T4991	T4992	det	these,analyses
R1163	T5039	T5038	acomp	clear,is
R1164	T4992	T4989	pobj	analyses,From
R1165	T4993	T4990	nsubj	we,constructed
R1166	T4994	T4995	compound	receiver,operating
R1167	T4995	T4996	npadvmod	operating,like
R1168	T5040	T5038	prep	from,is
R1169	T5041	T5042	det	the,curves
R1170	T4996	T5002	amod	like,curves
R1171	T4997	T4995	amod	characteristic,operating
R1172	T5042	T5040	pobj	curves,from
R1173	T4998	T4995	punct	(,operating
R1174	T4999	T4995	appos	ROC,operating
R1175	T5000	T4996	punct	),like
R1176	T5001	T4996	punct	-,like
R1177	T5002	T4990	dobj	curves,constructed
R1178	T5003	T5004	aux	to,demonstrate
R1179	T5043	T5042	compound	ROC,curves
R1180	T5004	T4990	advcl	demonstrate,constructed
R1181	T5005	T5006	mark	that,has
R1182	T5044	T5045	mark	that,add
R1183	T5006	T5004	ccomp	has,demonstrate
R1184	T5007	T5008	poss	our,method
R1185	T5045	T5038	ccomp	add,is
R1186	T5008	T5006	nsubj	method,has
R1187	T5009	T5008	amod	straightforward,method
R1188	T5010	T5011	advmod	significantly,increased
R1189	T5046	T5047	det	the,terms
R1190	T5011	T5012	amod	increased,power
R1191	T5012	T5006	dobj	power,has
R1192	T5047	T5045	nsubj	terms,add
R1193	T5013	T5014	aux	to,detect
R1194	T5014	T5012	acl	detect,power
R1195	T5048	T5047	nmod	sex,terms
R1196	T5049	T5048	cc	and,sex
R1197	T5050	T5051	compound	sex,interaction
R1198	T5051	T5048	conj	interaction,sex
R1199	T5052	T5051	punct	-,interaction
R1200	T5053	T5045	advmod	significantly,add
R1201	T5121	T5113	punct	", ",0.05
R1202	T5054	T5045	prep	to,add
R1203	T5122	T5123	npadvmod	genome,wide
R1204	T5123	T5125	amod	wide,p
R1205	T5055	T5056	det	the,detection
R1206	T5124	T5123	punct	-,wide
R1207	T5125	T5113	nsubj	p,0.05
R1208	T5056	T5054	pobj	detection,to
R1209	T5126	T5113	punct	<,0.05
R1210	T5127	T5113	punct	),0.05
R1211	T5128	T5067	punct	.,have
R1212	T5057	T5056	prep	of,detection
R1213	T5130	T5131	compound	QTL,models
R1214	T5058	T5057	pobj	QTL,of
R1215	T5131	T5132	nsubj	models,have
R1216	T5059	T5056	prep	for,detection
R1217	T5133	T5131	acl	incorporating,models
R1218	T5134	T5133	advmod	only,incorporating
R1219	T5060	T5061	det	the,traits
R1220	T5135	T5136	det	the,term
R1221	T5136	T5133	dobj	term,incorporating
R1222	T5137	T5138	nmod	sex,add
R1223	T5061	T5059	pobj	traits,for
R1224	T5138	T5136	compound	add,term
R1225	T5139	T5138	punct	*,add
R1226	T5140	T5136	compound	interaction,term
R1227	T5141	T5136	prep	in,term
R1228	T5142	T5141	pobj	addition,in
R1229	T5143	T5142	prep	to,addition
R1230	T5062	T5063	compound	gene,expression
R1231	T5144	T5145	det	the,terms
R1232	T5145	T5143	pobj	terms,to
R1233	T5146	T5145	amod	additive,terms
R1234	T5063	T5061	compound	expression,traits
R1235	T5147	T5148	nummod	one,degree
R1236	T5148	T5132	dobj	degree,have
R1237	T5149	T5148	amod	extra,degree
R1238	T5064	T5038	punct	.,is
R1239	T5150	T5148	prep	of,degree
R1240	T5151	T5150	pobj	freedom,of
R1241	T5152	T5153	dep	that,leads
R1242	T5066	T5067	advcl	Using,have
R1243	T5153	T5148	relcl	leads,degree
R1244	T5154	T5153	prep	to,leads
R1245	T5155	T5156	det	a,increase
R1246	T5156	T5154	pobj	increase,to
R1247	T5068	T5069	advmod	previously,described
R1248	T5157	T5156	amod	corresponding,increase
R1249	T5158	T5156	prep	in,increase
R1250	T5159	T5160	det	the,thresholds
R1251	T5160	T5158	pobj	thresholds,in
R1252	T5069	T5070	amod	described,conventions
R1253	T5161	T5160	compound	LOD,thresholds
R1254	T5162	T5160	compound	score,thresholds
R1255	T5163	T5156	prep	to,increase
R1256	T5070	T5066	dobj	conventions,Using
R1257	T5164	T5163	pobj	3.5,to
R1258	T5071	T5072	punct	[,20
R1259	T5072	T5066	parataxis	20,Using
R1260	T5165	T5166	punct	(,suggestive
R1261	T5166	T5164	parataxis	suggestive,3.5
R1262	T5073	T5072	punct	],20
R1263	T5167	T5166	punct	),suggestive
R1264	T5168	T5164	cc	and,3.5
R1265	T5169	T5164	conj	4.9,3.5
R1266	T5074	T5067	punct	", ",have
R1267	T5170	T5171	punct	(,significant
R1268	T5075	T5076	compound	QTL,models
R1269	T5171	T5169	parataxis	significant,4.9
R1270	T5172	T5171	punct	),significant
R1271	T5076	T5067	nsubj	models,have
R1272	T5173	T5164	prep	for,3.5
R1273	T5174	T5175	det	the,thresholds
R1274	T5077	T5076	prep	without,models
R1275	T5175	T5173	pobj	thresholds,for
R1276	T5176	T5175	nummod	0.001,thresholds
R1277	T5177	T5176	cc	and,0.001
R1278	T5178	T5176	conj	0.00005,0.001
R1279	T5179	T5180	compound	p,value
R1280	T5180	T5175	compound	value,thresholds
R1281	T5181	T5180	punct	-,value
R1282	T5078	T5079	det	the,terms
R1283	T5182	T5153	punct	", ",leads
R1284	T5183	T5153	advmod	respectively,leads
R1285	T5184	T5132	punct	.,have
R1286	T5079	T5077	pobj	terms,without
R1287	T5186	T5187	compound	QTL,models
R1288	T5187	T5188	nsubj	models,possess
R1289	T5080	T5079	amod	final,terms
R1290	T5189	T5187	acl	incorporating,models
R1291	T5190	T5191	preconj	both,add
R1292	T5081	T5079	nummod	two,terms
R1293	T5191	T5194	nmod	add,terms
R1294	T5192	T5191	nmod	sex,add
R1295	T5193	T5191	punct	*,add
R1296	T5082	T5079	compound	interaction,terms
R1297	T5194	T5189	dobj	terms,incorporating
R1298	T5195	T5191	cc	and,add
R1299	T5196	T5197	nmod	sex,dom
R1300	T5083	T5079	punct	(,terms
R1301	T5197	T5191	conj	dom,add
R1302	T5198	T5197	punct	*,dom
R1303	T5199	T5194	compound	interaction,terms
R1304	T5200	T5201	nummod	two,degrees
R1305	T5201	T5188	dobj	degrees,possess
R1306	T5202	T5201	amod	extra,degrees
R1307	T5084	T5085	nmod	sex,add
R1308	T5203	T5201	prep	of,degrees
R1309	T5204	T5203	pobj	freedom,of
R1310	T5205	T5188	punct	", ",possess
R1311	T5085	T5079	appos	add,terms
R1312	T5206	T5188	prep	with,possess
R1313	T5207	T5208	det	a,increase
R1314	T5086	T5085	punct	*,add
R1315	T5208	T5206	pobj	increase,with
R1316	T5209	T5208	amod	corresponding,increase
R1317	T5210	T5208	prep	in,increase
R1318	T5087	T5085	cc	and,add
R1319	T5211	T5212	compound	LOD,thresholds
R1320	T5088	T5089	nmod	sex,dom
R1321	T5212	T5210	pobj	thresholds,in
R1322	T5213	T5212	compound	score,thresholds
R1323	T5214	T5208	prep	to,increase
R1324	T5215	T5214	pobj	4.0,to
R1325	T5089	T5085	conj	dom,add
R1326	T5216	T5217	punct	(,suggestive
R1327	T5217	T5215	parataxis	suggestive,4.0
R1328	T5218	T5217	punct	),suggestive
R1329	T5219	T5215	cc	and,4.0
R1330	T5220	T5215	conj	5.4,4.0
R1331	T5221	T5222	punct	(,significant
R1332	T5222	T5220	parataxis	significant,5.4
R1333	T5090	T5089	punct	*,dom
R1334	T5223	T5222	punct	),significant
R1335	T5224	T5215	prep	for,4.0
R1336	T5225	T5226	det	the,thresholds
R1337	T5091	T5067	punct	),have
R1338	T5226	T5224	pobj	thresholds,for
R1339	T5092	T5093	det	a,threshold
R1340	T5093	T5067	dobj	threshold,have
R1341	T5094	T5093	amod	suggestive,threshold
R1342	T5095	T5093	prep	of,threshold
R1343	T5227	T5226	nummod	0.001,thresholds
R1344	T5228	T5227	cc	and,0.001
R1345	T5096	T5095	pobj	3.0,of
R1346	T5229	T5227	conj	0.00005,0.001
R1347	T5230	T5231	compound	p,value
R1348	T5231	T5226	compound	value,thresholds
R1349	T5097	T5098	punct	(,1
R1350	T5232	T5231	punct	-,value
R1351	T5233	T5208	punct	", ",increase
R1352	T5234	T5208	advmod	respectively,increase
R1353	T5098	T5096	parataxis	1,3.0
R1354	T5235	T5188	punct	.,possess
R1355	T5237	T5238	advmod	One,suggestive
R1356	T5099	T5098	nsubj	p,1
R1357	T5238	T5239	amod	suggestive,cQTLs
R1358	T5100	T5098	punct	<,1
R1359	T5101	T5098	punct	×,1
R1360	T5239	T5258	nsubjpass	cQTLs,identified
R1361	T5240	T5241	punct	(,Chromosome
R1362	T5102	T5103	nummod	10,3
R1363	T5241	T5238	parataxis	Chromosome,suggestive
R1364	T5242	T5241	nummod	1,Chromosome
R1365	T5243	T5241	punct	),Chromosome
R1366	T5103	T5098	appos	3,1
R1367	T5244	T5238	cc	and,suggestive
R1368	T5245	T5246	advmod	four,significant
R1369	T5104	T5103	punct	−,3
R1370	T5246	T5238	conj	significant,suggestive
R1371	T5247	T5248	punct	(,3
R1372	T5248	T5246	parataxis	3,significant
R1373	T5105	T5098	punct	),1
R1374	T5249	T5248	nmod	Chromosomes,3
R1375	T5250	T5248	punct	", ",3
R1376	T5251	T5248	conj	5,3
R1377	T5106	T5093	cc	and,threshold
R1378	T5252	T5251	punct	", ",5
R1379	T5253	T5251	conj	11,5
R1380	T5107	T5108	det	a,threshold
R1381	T5254	T5253	punct	", ",11
R1382	T5255	T5253	cc	and,11
R1383	T5256	T5253	conj	19,11
R1384	T5257	T5248	punct	),3
R1385	T5259	T5239	prep	for,cQTLs
R1386	T5108	T5093	conj	threshold,threshold
R1387	T5260	T5261	det	the,trait
R1388	T5261	T5259	pobj	trait,for
R1389	T5262	T5263	amod	gonadal,mass
R1390	T5109	T5108	amod	significant,threshold
R1391	T5263	T5261	compound	mass,trait
R1392	T5264	T5263	compound	fat,mass
R1393	T5265	T5258	auxpass	were,identified
R1394	T5110	T5108	prep	of,threshold
R1395	T5266	T5267	punct	(,Table
R1396	T5267	T5258	parataxis	Table,identified
R1397	T5111	T5110	pobj	4.3,of
R1398	T5268	T5269	compound	Figure,1A
R1399	T5269	T5267	dep	1A,Table
R1400	T5112	T5113	punct	(,0.05
R1401	T5270	T5267	punct	;,Table
R1402	T5271	T5267	nummod	2,Table
R1403	T5272	T5267	punct	),Table
R1404	T5273	T5258	punct	.,identified
R1405	T5113	T5111	parataxis	0.05,4.3
R1406	T5275	T5276	quantmod	Four,five
R1407	T5276	T5280	nummod	five,cQTLs
R1408	T5114	T5115	nsubj	p,5
R1409	T5277	T5276	quantmod	out,five
R1410	T5278	T5276	quantmod	of,five
R1411	T5279	T5276	quantmod	the,five
R1412	T5115	T5113	ccomp	5,0.05
R1413	T5280	T5281	nsubj	cQTLs,showed
R1414	T5282	T5283	advmod	statistically,significant
R1415	T5116	T5115	punct	<,5
R1416	T5283	T5284	amod	significant,fits
R1417	T5284	T5281	dobj	fits,showed
R1418	T5285	T5284	amod	better,fits
R1419	T5117	T5115	punct	×,5
R1420	T5286	T5281	prep	with,showed
R1421	T5287	T5288	det	the,model
R1422	T5288	T5286	pobj	model,with
R1423	T5118	T5119	nummod	10,5
R1424	T5289	T5288	amod	full,model
R1425	T5290	T5288	acl	incorporating,model
R1426	T5291	T5292	det	the,terms
R1427	T5119	T5115	appos	5,5
R1428	T5292	T5290	dobj	terms,incorporating
R1429	T5293	T5292	compound	interaction,terms
R1430	T5294	T5292	appos	sex,terms
R1431	T5120	T5119	punct	−,5
R1432	T5295	T5296	punct	*,add
R1433	T5296	T5294	prep	add,sex
R1434	T5297	T5294	cc	and,sex
R1435	T5298	T5294	conj	sex,sex
R1436	T5299	T5300	punct	*,dom
R1437	T5333	T5334	amod	improved,detection
R1438	T5300	T5298	prep	dom,sex
R1439	T5301	T5288	punct	", ",model
R1440	T5302	T5288	prep	compared,model
R1441	T5303	T5302	prep	to,compared
R1442	T5304	T5305	det	the,model
R1443	T5334	T5332	pobj	detection,to
R1444	T5305	T5303	pobj	model,to
R1445	T5306	T5305	prep	including,model
R1446	T5307	T5308	advmod	only,terms
R1447	T5308	T5306	pobj	terms,including
R1448	T5309	T5308	det	the,terms
R1449	T5310	T5308	amod	additive,terms
R1450	T5335	T5334	prep	of,detection
R1451	T5311	T5281	punct	.,showed
R1452	T5313	T5314	advmod	Interestingly,improve
R1453	T5336	T5337	det	this,locus
R1454	T5337	T5335	pobj	locus,of
R1455	T5315	T5314	punct	", ",improve
R1456	T5316	T5317	det	the,cQTL
R1457	T5338	T5314	punct	.,improve
R1458	T5317	T5314	nsubj	cQTL,improve
R1459	T5318	T5317	prep	over,cQTL
R1460	T5319	T5318	pobj	Chromosome,over
R1461	T5340	T5341	nsubj	Table,summarizes
R1462	T5320	T5319	nummod	11,Chromosome
R1463	T5321	T5314	aux	did,improve
R1464	T5322	T5314	neg	not,improve
R1465	T5323	T5314	punct	", ",improve
R1466	T5342	T5340	nummod	2,Table
R1467	T5324	T5314	advcl	suggesting,improve
R1468	T5325	T5326	mark	that,contribute
R1469	T5326	T5324	ccomp	contribute,suggesting
R1470	T5327	T5328	det	the,terms
R1471	T5328	T5326	nsubj	terms,contribute
R1472	T5343	T5344	det	the,position
R1473	T5329	T5328	amod	additional,terms
R1474	T5330	T5326	aux	did,contribute
R1475	T5331	T5326	neg	not,contribute
R1476	T5344	T5341	dobj	position,summarizes
R1477	T5332	T5326	prep	to,contribute
R1478	T5345	T5344	cc	and,position
R1479	T5346	T5347	compound	LOD,score
R1480	T5347	T5344	conj	score,position
R1481	T5439	T5438	prep	of,evidence
R1482	T5348	T5344	prep	of,position
R1483	T5440	T5439	pobj	linkage,of
R1484	T5441	T5438	prep	on,evidence
R1485	T5442	T5441	pobj	Chromosome,on
R1486	T5443	T5442	nummod	5,Chromosome
R1487	T5349	T5350	amod	maximal,linkage
R1488	T5444	T5425	punct	.,failed
R1489	T5446	T5447	advmod	When,analyzed
R1490	T5350	T5348	pobj	linkage,of
R1491	T5447	T5450	advcl	analyzed,realized
R1492	T5448	T5447	nsubjpass	females,analyzed
R1493	T5449	T5447	auxpass	were,analyzed
R1494	T5351	T5341	prep	for,summarizes
R1495	T5450	T5460	ccomp	realized,demonstrate
R1496	T5451	T5447	advmod	alone,analyzed
R1497	T5452	T5450	punct	", ",realized
R1498	T5352	T5353	det	each,cQTL
R1499	T5453	T5454	det	a,score
R1500	T5454	T5450	nsubjpass	score,realized
R1501	T5455	T5454	amod	suggestive,score
R1502	T5353	T5351	pobj	cQTL,for
R1503	T5456	T5454	compound	LOD,score
R1504	T5457	T5454	prep	of,score
R1505	T5458	T5457	pobj	3.7,of
R1506	T5459	T5450	auxpass	was,realized
R1507	T5354	T5341	punct	.,summarizes
R1508	T5461	T5462	punct	(,2
R1509	T5462	T5450	parataxis	2,realized
R1510	T5356	T5357	mark	While,was
R1511	T5463	T5462	nsubj	p,2
R1512	T5464	T5462	punct	=,2
R1513	T5465	T5462	punct	×,2
R1514	T5357	T5363	advcl	was,noted
R1515	T5466	T5467	nummod	10,4
R1516	T5467	T5462	appos	4,2
R1517	T5358	T5359	det	the,focus
R1518	T5468	T5467	punct	−,4
R1519	T5469	T5462	punct	),2
R1520	T5470	T5460	punct	;,demonstrate
R1521	T5359	T5357	nsubj	focus,was
R1522	T5471	T5460	nsubj	males,demonstrate
R1523	T5472	T5471	acl	analyzed,males
R1524	T5473	T5472	advmod	alone,analyzed
R1525	T5360	T5359	prep	of,focus
R1526	T5474	T5460	aux	did,demonstrate
R1527	T5475	T5460	neg	not,demonstrate
R1528	T5476	T5460	dobj	evidence,demonstrate
R1529	T5361	T5362	det	this,study
R1530	T5477	T5476	prep	for,evidence
R1531	T5478	T5477	pobj	linkage,for
R1532	T5362	T5360	pobj	study,of
R1533	T5479	T5460	punct	.,demonstrate
R1534	T5481	T5482	advmod	However,improved
R1535	T5364	T5365	det	the,trait
R1536	T5483	T5482	punct	", ",improved
R1537	T5484	T5482	csubj	using,improved
R1538	T5485	T5486	det	all,animals
R1539	T5486	T5484	dobj	animals,using
R1540	T5487	T5486	nummod	334,animals
R1541	T5365	T5357	attr	trait,was
R1542	T5488	T5484	cc	and,using
R1543	T5489	T5484	conj	adding,using
R1544	T5366	T5367	amod	gonadal,mass
R1545	T5490	T5491	det	the,terms
R1546	T5491	T5489	dobj	terms,adding
R1547	T5492	T5491	compound	interaction,terms
R1548	T5367	T5365	compound	mass,trait
R1549	T5493	T5489	prep	to,adding
R1550	T5494	T5495	det	the,model
R1551	T5495	T5493	pobj	model,to
R1552	T5368	T5367	compound	fat,mass
R1553	T5496	T5495	compound	QTL,model
R1554	T5497	T5482	advmod	significantly,improved
R1555	T5498	T5482	dobj	sensitivity,improved
R1556	T5369	T5363	punct	", ",noted
R1557	T5499	T5482	punct	", ",improved
R1558	T5500	T5482	cc	and,improved
R1559	T5370	T5363	nsubjpass	it,noted
R1560	T5501	T5502	det	a,cQTL
R1561	T5502	T5503	nsubjpass	cQTL,realized
R1562	T5371	T5363	auxpass	is,noted
R1563	T5372	T5373	mark	that,resulted
R1564	T5503	T5482	conj	realized,improved
R1565	T5373	T5363	ccomp	resulted,noted
R1566	T5504	T5502	prep	with,cQTL
R1567	T5505	T5506	det	a,LOD
R1568	T5374	T5375	det	a,scan
R1569	T5506	T5504	pobj	LOD,with
R1570	T5507	T5506	compound	maximum,LOD
R1571	T5508	T5506	prep	of,LOD
R1572	T5375	T5373	nsubj	scan,resulted
R1573	T5509	T5508	pobj	7.56,of
R1574	T5510	T5511	punct	(,1.7
R1575	T5511	T5502	parataxis	1.7,cQTL
R1576	T5376	T5375	compound	genome,scan
R1577	T5512	T5511	nsubj	p,1.7
R1578	T5513	T5511	punct	=,1.7
R1579	T5514	T5511	punct	×,1.7
R1580	T5377	T5375	prep	for,scan
R1581	T5515	T5516	nummod	10,6
R1582	T5516	T5511	appos	6,1.7
R1583	T5517	T5516	punct	−,6
R1584	T5378	T5379	det	the,trait
R1585	T5518	T5511	punct	),1.7
R1586	T5519	T5503	auxpass	was,realized
R1587	T5520	T5482	punct	.,improved
R1588	T5522	T5523	prep	Given,hypothesized
R1589	T5379	T5377	pobj	trait,for
R1590	T5524	T5525	det	the,detection
R1591	T5525	T5522	pobj	detection,Given
R1592	T5380	T5379	compound	adiposity,trait
R1593	T5526	T5525	amod	improved,detection
R1594	T5527	T5525	prep	of,detection
R1595	T5528	T5529	quantmod	four,five
R1596	T5381	T5373	prep	in,resulted
R1597	T5529	T5532	nummod	five,cQTLs
R1598	T5530	T5529	quantmod	of,five
R1599	T5531	T5529	quantmod	the,five
R1600	T5382	T5381	pobj	cQTLs,in
R1601	T5532	T5527	pobj	cQTLs,of
R1602	T5533	T5534	advmod	when,considered
R1603	T5534	T5525	relcl	considered,detection
R1604	T5383	T5382	prep	at,cQTLs
R1605	T5535	T5536	npadvmod	sex,additive
R1606	T5536	T5538	amod	additive,terms
R1607	T5537	T5536	punct	-,additive
R1608	T5384	T5385	det	the,locations
R1609	T5538	T5534	nsubjpass	terms,considered
R1610	T5539	T5536	cc	and,additive
R1611	T5540	T5541	npadvmod	sex,dominant
R1612	T5385	T5383	pobj	locations,at
R1613	T5541	T5536	conj	dominant,additive
R1614	T5542	T5541	punct	-,dominant
R1615	T5543	T5538	compound	interaction,terms
R1616	T5386	T5385	amod	same,locations
R1617	T5544	T5534	auxpass	were,considered
R1618	T5387	T5382	punct	", ",cQTLs
R1619	T5388	T5382	prep	with,cQTLs
R1620	T5545	T5523	punct	", ",hypothesized
R1621	T5389	T5390	advmod	very,similar
R1622	T5546	T5523	nsubj	we,hypothesized
R1623	T5547	T5548	mark	that,differ
R1624	T5390	T5391	amod	similar,scores
R1625	T5548	T5523	ccomp	differ,hypothesized
R1626	T5549	T5550	det	the,effect
R1627	T5550	T5548	nsubj	effect,differ
R1628	T5391	T5388	pobj	scores,with
R1629	T5551	T5550	amod	main,effect
R1630	T5552	T5550	compound	genotype,effect
R1631	T5553	T5550	prep	of,effect
R1632	T5392	T5391	compound	LOD,scores
R1633	T5554	T5555	det	these,cQTLs
R1634	T5555	T5553	pobj	cQTLs,of
R1635	T5556	T5550	prep	on,effect
R1636	T5393	T5391	cc	and,scores
R1637	T5557	T5558	det	the,trait
R1638	T5558	T5556	pobj	trait,on
R1639	T5559	T5560	amod	gonadal,mass
R1640	T5560	T5558	compound	mass,trait
R1641	T5561	T5560	compound	fat,mass
R1642	T5562	T5548	aux	would,differ
R1643	T5394	T5395	compound	sex,dependence
R1644	T5563	T5548	prep	between,differ
R1645	T5564	T5565	det	the,sexes
R1646	T5395	T5391	conj	dependence,scores
R1647	T5565	T5563	pobj	sexes,between
R1648	T5396	T5397	punct	(,data
R1649	T5566	T5567	punct	(,Figure
R1650	T5567	T5523	parataxis	Figure,hypothesized
R1651	T5568	T5567	nummod	2,Figure
R1652	T5569	T5567	punct	),Figure
R1653	T5397	T5363	parataxis	data,noted
R1654	T5570	T5523	punct	.,hypothesized
R1655	T5398	T5397	amod	unpublished,data
R1656	T5572	T5573	advmod	Indeed,showed
R1657	T5574	T5573	punct	", ",showed
R1658	T5399	T5397	punct	),data
R1659	T5575	T5573	nsubj	cQTLs,showed
R1660	T5576	T5575	acl	located,cQTLs
R1661	T5577	T5576	prep	on,located
R1662	T5400	T5363	punct	.,noted
R1663	T5578	T5579	nmod	Chromosomes,1
R1664	T5579	T5577	pobj	1,on
R1665	T5580	T5579	punct	", ",1
R1666	T5402	T5403	nsubjpass	Results,depicted
R1667	T5581	T5579	conj	3,1
R1668	T5582	T5581	punct	", ",3
R1669	T5583	T5581	cc	and,3
R1670	T5584	T5581	conj	5,3
R1671	T5585	T5586	amod	opposing,effects
R1672	T5404	T5402	prep	from,Results
R1673	T5586	T5573	dobj	effects,showed
R1674	T5587	T5586	prep	on,effects
R1675	T5588	T5589	compound	fat,mass
R1676	T5589	T5587	pobj	mass,on
R1677	T5405	T5406	det	the,models
R1678	T5406	T5404	pobj	models,from
R1679	T5590	T5589	punct	", ",mass
R1680	T5591	T5589	cc	or,mass
R1681	T5407	T5406	amod	various,models
R1682	T5592	T5593	compound	sex,antagonism
R1683	T5593	T5589	conj	antagonism,mass
R1684	T5594	T5573	punct	.,showed
R1685	T5408	T5406	compound	regression,models
R1686	T5596	T5597	det	The,effect
R1687	T5597	T5598	nsubj	effect,was
R1688	T5409	T5406	acl	used,models
R1689	T5599	T5597	prep	of,effect
R1690	T5600	T5601	det	the,cQTL
R1691	T5410	T5411	aux	to,determine
R1692	T5601	T5599	pobj	cQTL,of
R1693	T5602	T5597	prep	on,effect
R1694	T5603	T5602	pobj	Chromosome,on
R1695	T5604	T5603	nummod	11,Chromosome
R1696	T5605	T5598	prep	in,was
R1697	T5411	T5409	advcl	determine,used
R1698	T5606	T5607	det	the,direction
R1699	T5607	T5605	pobj	direction,in
R1700	T5608	T5607	amod	same,direction
R1701	T5412	T5411	dobj	linkage,determine
R1702	T5609	T5598	prep	in,was
R1703	T5610	T5611	preconj	both,males
R1704	T5413	T5411	prep	for,determine
R1705	T5611	T5609	pobj	males,in
R1706	T5612	T5611	cc	and,males
R1707	T5613	T5611	conj	females,males
R1708	T5414	T5415	det	the,cQTL
R1709	T5614	T5598	punct	", ",was
R1710	T5615	T5598	cc	but,was
R1711	T5616	T5617	auxpass	was,biased
R1712	T5415	T5413	pobj	cQTL,for
R1713	T5617	T5598	conj	biased,was
R1714	T5618	T5617	dep	sex,biased
R1715	T5619	T5617	punct	-,biased
R1716	T5416	T5415	nmod	Chromosome,cQTL
R1717	T5620	T5617	prep	toward,biased
R1718	T5621	T5622	det	a,effect
R1719	T5622	T5620	pobj	effect,toward
R1720	T5417	T5416	nummod	5,Chromosome
R1721	T5623	T5622	amod	larger,effect
R1722	T5624	T5622	prep	in,effect
R1723	T5625	T5624	pobj	females,in
R1724	T5418	T5403	auxpass	are,depicted
R1725	T5626	T5627	punct	(,0.091
R1726	T5627	T5617	parataxis	0.091,biased
R1727	T5628	T5627	nsubj	R 2,0.091
R1728	T5419	T5403	prep	in,depicted
R1729	T5629	T5627	punct	=,0.091
R1730	T5630	T5627	prep	in,0.091
R1731	T5631	T5630	pobj	females,in
R1732	T5420	T5421	compound	Figure,1B
R1733	T5632	T5627	cc	versus,0.091
R1734	T5633	T5634	nsubj	R 2,0.046
R1735	T5634	T5627	conj	0.046,0.091
R1736	T5635	T5634	punct	=,0.046
R1737	T5636	T5634	prep	in,0.046
R1738	T5421	T5419	pobj	1B,in
R1739	T5637	T5636	pobj	males,in
R1740	T5638	T5627	punct	),0.091
R1741	T5639	T5598	punct	", ",was
R1742	T5422	T5403	punct	.,depicted
R1743	T5640	T5598	advcl	confirming,was
R1744	T5641	T5642	det	the,specificity
R1745	T5642	T5640	dobj	specificity,confirming
R1746	T5643	T5642	amod	minimal,specificity
R1747	T5644	T5642	compound	sex,specificity
R1748	T5645	T5642	prep	of,specificity
R1749	T5424	T5425	nsubj	Analysis,failed
R1750	T5646	T5647	det	this,cQTL
R1751	T5647	T5645	pobj	cQTL,of
R1752	T5426	T5424	prep	of,Analysis
R1753	T5648	T5598	punct	.,was
R1754	T5650	T5651	det	The,cQTL
R1755	T5427	T5428	det	all,animals
R1756	T5428	T5426	pobj	animals,of
R1757	T5651	T5652	nsubj	cQTL,showed
R1758	T5429	T5424	prep	with,Analysis
R1759	T5653	T5651	prep	on,cQTL
R1760	T5654	T5653	pobj	Chromosome,on
R1761	T5430	T5429	cc	and,with
R1762	T5655	T5654	nummod	19,Chromosome
R1763	T5656	T5657	det	a,effect
R1764	T5431	T5429	conj	without,with
R1765	T5657	T5652	dobj	effect,showed
R1766	T5658	T5659	npadvmod	sex,specific
R1767	T5659	T5657	amod	specific,effect
R1768	T5432	T5431	pobj	sex,without
R1769	T5660	T5659	punct	-,specific
R1770	T5661	T5652	prep	in,showed
R1771	T5662	T5661	pobj	females,in
R1772	T5433	T5432	prep	as,sex
R1773	T5663	T5652	punct	", ",showed
R1774	T5664	T5652	prep	with,showed
R1775	T5665	T5666	det	no,effect
R1776	T5434	T5435	det	a,covariate
R1777	T5666	T5664	pobj	effect,with
R1778	T5667	T5666	prep	in,effect
R1779	T5668	T5667	pobj	males,in
R1780	T5435	T5433	pobj	covariate,as
R1781	T5669	T5652	punct	.,showed
R1782	T5671	T5672	advmod	Overall,were
R1783	T5436	T5437	aux	to,demonstrate
R1784	T5673	T5672	punct	", ",were
R1785	T5674	T5675	det	all,cQTLs
R1786	T5437	T5425	xcomp	demonstrate,failed
R1787	T5675	T5672	nsubj	cQTLs,were
R1788	T5438	T5437	dobj	evidence,demonstrate
R1789	T5676	T5675	nummod	five,cQTLs
R1790	T5677	T5675	prep	for,cQTLs
R1791	T5678	T5679	amod	gonadal,mass
R1792	T5679	T5677	pobj	mass,for
R1793	T5680	T5679	compound	fat,mass
R1794	T5681	T5672	acomp	biased,were
R1795	T5682	T5681	prep	toward,biased
R1796	T5683	T5684	det	a,effect
R1797	T5684	T5682	pobj	effect,toward
R1798	T5685	T5684	amod	larger,effect
R1799	T5686	T5672	prep	in,were
R1800	T5687	T5686	pobj	females,in
R1801	T5688	T5672	punct	.,were
R1802	T5690	T5691	advcl	Assuming,account
R1803	T5692	T5693	advmod	purely,additive
R1804	T5693	T5694	amod	additive,effects
R1805	T5694	T5690	dobj	effects,Assuming
R1806	T5695	T5694	prep	of,effects
R1807	T5696	T5697	det	each,genotype
R1808	T5697	T5695	pobj	genotype,of
R1809	T5698	T5691	punct	", ",account
R1810	T5699	T5700	det	these,cQTLs
R1811	T5700	T5691	nsubj	cQTLs,account
R1812	T5701	T5691	prep	for,account
R1813	T5702	T5703	advmod	approximately,42
R1814	T5703	T5704	nummod	42,%
R1815	T5704	T5701	pobj	%,for
R1816	T5705	T5704	prep	of,%
R1817	T5706	T5707	det	the,variation
R1818	T5707	T5705	pobj	variation,of
R1819	T5708	T5704	prep	in,%
R1820	T5709	T5710	amod	female,mice
R1821	T5710	T5708	pobj	mice,in
R1822	T5711	T5710	compound	F2,mice
R1823	T5712	T5704	cc	and,%
R1824	T5713	T5714	nummod	13,%
R1825	T5714	T5704	conj	%,%
R1826	T5715	T5714	prep	in,%
R1827	T5716	T5715	pobj	males,in
R1828	T5717	T5691	punct	", ",account
R1829	T5718	T5691	advcl	consistent,account
R1830	T5719	T5718	prep	with,consistent
R1831	T5720	T5721	det	the,estimates
R1832	T5721	T5719	pobj	estimates,with
R1833	T5722	T5721	amod	narrow,estimates
R1834	T5723	T5721	compound	sense,estimates
R1835	T5724	T5721	compound	heritability,estimates
R1836	T5725	T5721	prep	for,estimates
R1837	T5726	T5727	det	this,trait
R1838	T5727	T5725	pobj	trait,for
R1839	T5728	T5718	cc	and,consistent
R1840	T5729	T5730	advmod	again,demonstrating
R1841	T5730	T5718	conj	demonstrating,consistent
R1842	T5731	T5732	amod	significant,differences
R1843	T5732	T5730	dobj	differences,demonstrating
R1844	T5733	T5732	prep	in,differences
R1845	T5734	T5735	det	the,regulation
R1846	T5735	T5733	pobj	regulation,in
R1847	T5736	T5735	cc	and,regulation
R1848	T5737	T5735	conj	heritability,regulation
R1849	T5738	T5735	prep	of,regulation
R1850	T5739	T5740	det	the,trait
R1851	T5740	T5738	pobj	trait,of
R1852	T5741	T5742	amod	gonadal,fat
R1853	T5742	T5740	compound	fat,trait
R1854	T5743	T5740	prep	between,trait
R1855	T5744	T5745	det	the,sexes
R1856	T5745	T5743	pobj	sexes,between
R1857	T5746	T5691	punct	.,account
R811	T4642	T4641	acl	Associated,QTLs
R812	T4643	T4642	prep	with,Associated
R813	T4644	T4645	amod	Gonadal,Mass
R814	T4645	T4643	pobj	Mass,with
R815	T4646	T4645	compound	Fat,Mass
R816	T4648	T4649	nsubjpass	Characteristics,summarized
R817	T4650	T4648	prep	of,Characteristics
R818	T4651	T4652	det	the,parents
R819	T4652	T4650	pobj	parents,of
R820	T4653	T4652	nmod	B6.ApoE,parents
R821	T4654	T4653	punct	−,B6.ApoE
R822	T4655	T4653	punct	/,B6.ApoE
R823	T4656	T4653	punct	−,B6.ApoE
R824	T4657	T4653	cc	and,B6.ApoE
R825	T4658	T4653	conj	C3H.ApoE,B6.ApoE
R826	T4659	T4658	punct	−,C3H.ApoE
R827	T4660	T4658	punct	/,C3H.ApoE
R828	T4661	T4658	punct	−,C3H.ApoE
R829	T4662	T4652	cc	and,parents
R830	T4663	T4664	det	the,generation
R831	T4664	T4652	conj	generation,parents
R832	T4665	T4664	nmod	F2,generation
R833	T4666	T4664	nmod	BXH.ApoE,generation
R834	T4667	T4666	punct	−,BXH.ApoE
R835	T4668	T4666	punct	/,BXH.ApoE
R836	T4669	T4666	punct	−,BXH.ApoE
R837	T4670	T4652	prep	on,parents
R838	T4671	T4672	det	a,diet
R839	T4672	T4670	pobj	diet,on
R840	T4673	T4672	compound	Western,diet
R841	T4674	T4649	auxpass	are,summarized
R842	T4675	T4649	prep	in,summarized
R843	T4676	T4675	pobj	Table,in
R844	T4677	T4676	nummod	1,Table
R845	T4678	T4649	punct	.,summarized
R846	T4680	T4681	amod	Gonadal,mass
R847	T4681	T4683	nsubj	mass,differed
R848	T4682	T4681	compound	fat,mass
R849	T4684	T4683	advmod	significantly,differed
R850	T4685	T4683	prep	between,differed
R851	T4686	T4687	det	the,sexes
R852	T4687	T4685	pobj	sexes,between
R853	T4688	T4683	prep	in,differed
R854	T4689	T4688	pobj	F2,in
R855	T4690	T4691	punct	(,4
R856	T4691	T4689	parataxis	4,F2
R857	T4692	T4691	nsubj	p,4
R858	T4693	T4691	punct	<,4
R859	T4694	T4691	nummod	10,4
R860	T4695	T4691	punct	−,4
R861	T4696	T4691	punct	),4
R862	T4697	T4688	cc	and,in
R863	T4698	T4688	conj	in,in
R864	T4699	T4700	det	the,C3H.ApoE
R865	T4700	T4698	pobj	C3H.ApoE,in
R866	T4701	T4700	amod	parental,C3H.ApoE
R867	T4702	T4700	punct	−,C3H.ApoE
R868	T4703	T4700	punct	/,C3H.ApoE
R869	T4704	T4700	punct	−,C3H.ApoE
R870	T4705	T4706	punct	(,0.05
R871	T4706	T4700	parataxis	0.05,C3H.ApoE
R872	T4707	T4706	nsubj	p,0.05
R873	T4708	T4706	punct	<,0.05
R874	T4709	T4706	punct	),0.05
R875	T4710	T4688	punct	", ",in
R876	T4711	T4688	cc	but,in
R877	T4712	T4711	neg	not,but
R878	T4713	T4688	conj	in,in
R879	T4714	T4715	nmod	B6.ApoE,mice
R880	T4715	T4713	pobj	mice,in
R881	T4716	T4714	punct	−,B6.ApoE
R882	T4717	T4714	punct	/,B6.ApoE
R883	T4718	T4714	punct	−,B6.ApoE
R884	T4719	T4683	punct	.,differed
R885	T4721	T4722	amod	Gonadal,mass
R886	T4722	T4724	nsubj	mass,was
R887	T4723	T4722	compound	fat,mass
R888	T4725	T4726	det	the,collection
R889	T4726	T4724	attr	collection,was
R890	T4727	T4728	compound	fat,pad
R891	T4728	T4726	compound	pad,collection
R892	T4729	T4730	dep	that,represented
R893	T4730	T4726	relcl	represented,collection
R894	T4731	T4732	det	the,animals
R895	T4732	T4730	dobj	animals,represented
R896	T4733	T4732	amod	most,animals
R897	T4734	T4732	cc	and,animals
R898	T4735	T4736	det	the,collections
R899	T4736	T4732	conj	collections,animals
R900	T4737	T4738	advmod	most,accurate
R901	T4738	T4736	amod	accurate,collections
R902	T4739	T4730	cc	and,represented
R903	T4740	T4741	auxpass	was,chosen
R904	T4741	T4730	conj	chosen,represented
R905	T4742	T4741	advmod	thus,chosen
R906	T4743	T4741	prep	for,chosen
R907	T4744	T4745	amod	further,analysis
R908	T4745	T4743	pobj	analysis,for
R909	T4746	T4724	punct	.,was
R910	T4748	T4749	amod	Broad,sense
R911	T4749	T4750	compound	sense,heritability
R912	T4750	T4751	nsubj	heritability,was
R913	T4752	T4753	punct	(,h 2
R914	T4753	T4750	parataxis	h 2,heritability
R915	T4754	T4753	punct	),h 2
R916	T4755	T4750	acl	calculated,heritability
R917	T4756	T4755	prep	as,calculated
R918	T4757	T4756	punct	(,as
R919	T4758	T4759	nmod	σ2 Total,σ2 Parental
R920	T4759	T4756	pobj	σ2 Parental,as
R921	T4760	T4759	punct	−,σ2 Parental
R922	T4761	T4759	punct	),σ2 Parental
R923	T4762	T4759	punct	/,σ2 Parental
R924	T4763	T4759	appos	σ2 Total,σ2 Parental
R925	T4764	T4755	prep	for,calculated
R926	T4765	T4766	det	the,trait
R927	T4766	T4764	pobj	trait,for
R928	T4767	T4768	amod	gonadal,mass
R929	T4768	T4766	compound	mass,trait
R930	T4769	T4768	compound	fat,mass
R931	T4770	T4771	nummod	54,%
R932	T4771	T4751	attr	%,was
R933	T4772	T4771	prep	for,%
R934	T4773	T4772	pobj	females,for
R935	T4774	T4771	cc	and,%
R936	T4775	T4776	nummod	36,%
R937	T4776	T4771	conj	%,%
R938	T4777	T4776	prep	for,%
R939	T4778	T4777	pobj	males,for
R940	T4779	T4771	punct	", ",%
R941	T4780	T4781	dep	which,is
R942	T4781	T4771	relcl	is,%
R943	T4782	T4781	prep	in,is
R944	T4783	T4784	amod	close,agreement
R945	T4784	T4782	pobj	agreement,in
R946	T4785	T4784	prep	with,agreement
R947	T4786	T4787	amod	previous,reports
R948	T4787	T4785	pobj	reports,with
R949	T4788	T4789	punct	[,19
R950	T4789	T4781	parataxis	19,is
R951	T4790	T4789	nummod	18,19
R952	T4791	T4789	punct	",",19
R953	T4792	T4789	punct	],19
R954	T4793	T4781	cc	and,is
R955	T4794	T4781	conj	demonstrates,is
R956	T4795	T4796	amod	significant,heritability
R957	T4796	T4794	dobj	heritability,demonstrates
R958	T4797	T4796	prep	of,heritability
R959	T4798	T4799	amod	gonadal,mass
R960	T4799	T4797	pobj	mass,of
R961	T4800	T4799	compound	fat,mass
R962	T4801	T4751	punct	.,was
R963	T4803	T4804	det	A,total
R964	T4804	T4805	nsubjpass	total,genotyped
R965	T4806	T4804	prep	of,total
R966	T4807	T4808	nummod	334,mice
R967	T4808	T4806	pobj	mice,of
R968	T4809	T4808	compound	F2,mice
R969	T4810	T4805	auxpass	were,genotyped
R970	T4811	T4805	prep	at,genotyped
R971	T4812	T4813	det	an,density
R972	T4813	T4811	pobj	density,at
R973	T4814	T4813	amod	average,density
R974	T4815	T4816	nummod	1.5,cM
R975	T4816	T4813	compound	cM,density
R976	T4817	T4805	advcl	using,genotyped
R977	T4818	T4819	nummod	"1,032",polymorphisms
R978	T4819	T4817	dobj	polymorphisms,using
R979	T4820	T4821	amod	single,nucleotide
R980	T4821	T4819	compound	nucleotide,polymorphisms
R981	T4822	T4819	punct	(,polymorphisms
R982	T4823	T4819	appos	SNPs,polymorphisms
R983	T4824	T4819	punct	),polymorphisms
R984	T4825	T4819	acl	spanning,polymorphisms
R985	T4826	T4827	det	all,autosomes
R986	T4827	T4825	dobj	autosomes,spanning
R987	T4828	T4827	nummod	19,autosomes
R988	T4829	T4805	punct	.,genotyped
R989	T4831	T4832	compound	QTL,analysis
R990	T4832	T4833	nsubjpass	analysis,performed
R991	T4834	T4832	prep	for,analysis
R992	T4835	T4836	amod	several,traits
R993	T4836	T4834	pobj	traits,for
R994	T4837	T4836	amod	clinical,traits
R995	T4838	T4839	punct	(,QTLs
R996	T4839	T4836	parataxis	QTLs,traits
R997	T4840	T4839	amod	clinical,QTLs
R998	T4841	T4839	punct	[,QTLs
R999	T4842	T4839	appos	cQTLs,QTLs

PMC:1359071 / 6169-13302 JSONTXT 4 Projects

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PMC:1359071 / 6169-13302 JSON TXT 4 Projects