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PMC:1359071 / 4084-5343 JSONTXT 4 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function

Id Subject Object Predicate Lexical cue
T2203 0-2 PRP denotes We
T2205 3-7 VBP denotes have
T2204 8-16 VBN denotes utilized
T2206 17-20 DT denotes the
T2207 21-26 NN denotes mouse
T2208 27-29 IN denotes as
T2209 30-31 DT denotes a
T2211 32-37 NN denotes model
T2210 38-44 NN denotes system
T2212 45-47 TO denotes to
T2213 48-53 VB denotes study
T2214 54-57 DT denotes the
T2215 58-66 NN denotes genetics
T2216 67-69 IN denotes of
T2217 70-79 JJ denotes metabolic
T2219 80-83 CC denotes and
T2220 84-92 JJ denotes vascular
T2218 93-101 NNS denotes diseases
T2221 102-103 -LRB- denotes [
T2222 103-104 CD denotes 3
T2223 104-105 SYM denotes –
T2224 105-106 CD denotes 5
T2225 106-107 -RRB- denotes ]
T2226 107-108 . denotes .
T2227 108-385 sentence denotes Rather than focus initially on natural or induced mutants of single genes, we utilize the complex endogenous genetic variation between strains in genetic crosses to identify causative genetic loci and ultimately the underlying variations responsible for trait differences [6].
T2228 109-115 RB denotes Rather
T2230 116-120 IN denotes than
T2231 121-126 VBP denotes focus
T2232 127-136 RB denotes initially
T2233 137-139 IN denotes on
T2234 140-147 JJ denotes natural
T2236 148-150 CC denotes or
T2237 151-158 VBN denotes induced
T2235 159-166 NNS denotes mutants
T2238 167-169 IN denotes of
T2239 170-176 JJ denotes single
T2240 177-182 NNS denotes genes
T2241 182-184 , denotes ,
T2242 184-186 PRP denotes we
T2229 187-194 VBP denotes utilize
T2243 195-198 DT denotes the
T2245 199-206 JJ denotes complex
T2246 207-217 JJ denotes endogenous
T2247 218-225 JJ denotes genetic
T2244 226-235 NN denotes variation
T2248 236-243 IN denotes between
T2249 244-251 NNS denotes strains
T2250 252-254 IN denotes in
T2251 255-262 JJ denotes genetic
T2252 263-270 NNS denotes crosses
T2253 271-273 TO denotes to
T2254 274-282 VB denotes identify
T2255 283-292 JJ denotes causative
T2257 293-300 JJ denotes genetic
T2256 301-305 NNS denotes loci
T2258 306-309 CC denotes and
T2259 310-320 RB denotes ultimately
T2261 321-324 DT denotes the
T2262 325-335 VBG denotes underlying
T2260 336-346 NNS denotes variations
T2263 347-358 JJ denotes responsible
T2264 359-362 IN denotes for
T2265 363-368 NN denotes trait
T2266 369-380 NNS denotes differences
T2267 381-382 -LRB- denotes [
T2268 382-383 CD denotes 6
T2269 383-384 -RRB- denotes ]
T2270 384-385 . denotes .
T2271 385-472 sentence denotes This design more closely reflects the situation faced when studying human populations.
T2272 386-390 DT denotes This
T2273 391-397 NN denotes design
T2275 398-402 RBR denotes more
T2276 403-410 RB denotes closely
T2274 411-419 VBZ denotes reflects
T2277 420-423 DT denotes the
T2278 424-433 NN denotes situation
T2279 434-439 VBN denotes faced
T2280 440-444 WRB denotes when
T2281 445-453 VBG denotes studying
T2282 454-459 JJ denotes human
T2283 460-471 NNS denotes populations
T2284 471-472 . denotes .
T2285 472-620 sentence denotes The genetic composition of each individual mouse is restricted to that of the two parental strains and is defined at every locus across the genome.
T2286 473-476 DT denotes The
T2288 477-484 JJ denotes genetic
T2287 485-496 NN denotes composition
T2290 497-499 IN denotes of
T2291 500-504 DT denotes each
T2293 505-515 JJ denotes individual
T2292 516-521 NN denotes mouse
T2294 522-524 VBZ denotes is
T2289 525-535 VBN denotes restricted
T2295 536-538 IN denotes to
T2296 539-543 DT denotes that
T2297 544-546 IN denotes of
T2298 547-550 DT denotes the
T2300 551-554 CD denotes two
T2301 555-563 JJ denotes parental
T2299 564-571 NNS denotes strains
T2302 572-575 CC denotes and
T2303 576-578 VBZ denotes is
T2304 579-586 VBN denotes defined
T2305 587-589 IN denotes at
T2306 590-595 DT denotes every
T2307 596-601 NN denotes locus
T2308 602-608 IN denotes across
T2309 609-612 DT denotes the
T2310 613-619 NN denotes genome
T2311 619-620 . denotes .
T2312 620-846 sentence denotes The application of quantitative trait locus (QTL) analysis allows the identification of those chromosomal regions that contain a genetic variation that influences trait expression (for a comprehensive review on QTLs see [7]).
T2313 621-624 DT denotes The
T2314 625-636 NN denotes application
T2316 637-639 IN denotes of
T2317 640-652 JJ denotes quantitative
T2318 653-658 NN denotes trait
T2319 659-664 NN denotes locus
T2321 665-666 -LRB- denotes (
T2322 666-669 NN denotes QTL
T2323 669-670 -RRB- denotes )
T2320 671-679 NN denotes analysis
T2315 680-686 VBZ denotes allows
T2324 687-690 DT denotes the
T2325 691-705 NN denotes identification
T2326 706-708 IN denotes of
T2327 709-714 DT denotes those
T2329 715-726 JJ denotes chromosomal
T2328 727-734 NNS denotes regions
T2330 735-739 WDT denotes that
T2331 740-747 VBP denotes contain
T2332 748-749 DT denotes a
T2334 750-757 JJ denotes genetic
T2333 758-767 NN denotes variation
T2335 768-772 WDT denotes that
T2336 773-783 VBZ denotes influences
T2337 784-789 NN denotes trait
T2338 790-800 NN denotes expression
T2339 801-802 -LRB- denotes (
T2341 802-805 IN denotes for
T2342 806-807 DT denotes a
T2344 808-821 JJ denotes comprehensive
T2343 822-828 NN denotes review
T2345 829-831 IN denotes on
T2346 832-836 NNS denotes QTLs
T2340 837-840 VBP denotes see
T2347 841-842 -LRB- denotes [
T2348 842-843 CD denotes 7
T2349 843-844 -RRB- denotes ]
T2350 844-845 -RRB- denotes )
T2351 845-846 . denotes .
T2352 846-1068 sentence denotes We [5,8], and others [9–17], have recently extended the power of this approach by incorporating genome-wide gene expression array analysis, which allows us to model the “genetics of gene expression” using similar methods.
T2353 847-849 PRP denotes We
T2355 850-851 -LRB- denotes [
T2357 851-852 CD denotes 5
T2358 852-853 , denotes ,
T2356 853-854 CD denotes 8
T2359 854-855 -RRB- denotes ]
T2360 855-857 , denotes ,
T2361 857-860 CC denotes and
T2362 861-867 NNS denotes others
T2363 868-869 -LRB- denotes [
T2364 869-870 CD denotes 9
T2365 870-871 SYM denotes –
T2366 871-873 CD denotes 17
T2367 873-874 -RRB- denotes ]
T2368 874-876 , denotes ,
T2369 876-880 VBP denotes have
T2370 881-889 RB denotes recently
T2354 890-898 VBN denotes extended
T2371 899-902 DT denotes the
T2372 903-908 NN denotes power
T2373 909-911 IN denotes of
T2374 912-916 DT denotes this
T2375 917-925 NN denotes approach
T2376 926-928 IN denotes by
T2377 929-942 VBG denotes incorporating
T2378 943-949 NN denotes genome
T2380 949-950 HYPH denotes -
T2379 950-954 JJ denotes wide
T2382 955-959 NN denotes gene
T2383 960-970 NN denotes expression
T2384 971-976 NN denotes array
T2381 977-985 NN denotes analysis
T2385 985-987 , denotes ,
T2386 987-992 WDT denotes which
T2387 993-999 VBZ denotes allows
T2388 1000-1002 PRP denotes us
T2390 1003-1005 TO denotes to
T2389 1006-1011 VB denotes model
T2391 1012-1015 DT denotes the
T2393 1016-1017 `` denotes “
T2392 1017-1025 NN denotes genetics
T2394 1026-1028 IN denotes of
T2395 1029-1033 NN denotes gene
T2396 1034-1044 NN denotes expression
T2397 1044-1045 '' denotes ”
T2398 1046-1051 VBG denotes using
T2399 1052-1059 JJ denotes similar
T2400 1060-1067 NNS denotes methods
T2401 1067-1068 . denotes .
T2402 1068-1259 sentence denotes An immediate extension of this approach is toward dissecting the genetic regulation of complex phenotypes, which would greatly improve the progression from candidate locus to candidate gene.
T2403 1069-1071 DT denotes An
T2405 1072-1081 JJ denotes immediate
T2404 1082-1091 NN denotes extension
T2407 1092-1094 IN denotes of
T2408 1095-1099 DT denotes this
T2409 1100-1108 NN denotes approach
T2406 1109-1111 VBZ denotes is
T2410 1112-1118 IN denotes toward
T2411 1119-1129 VBG denotes dissecting
T2412 1130-1133 DT denotes the
T2414 1134-1141 JJ denotes genetic
T2413 1142-1152 NN denotes regulation
T2415 1153-1155 IN denotes of
T2416 1156-1163 JJ denotes complex
T2417 1164-1174 NNS denotes phenotypes
T2418 1174-1176 , denotes ,
T2419 1176-1181 WDT denotes which
T2421 1182-1187 MD denotes would
T2422 1188-1195 RB denotes greatly
T2420 1196-1203 VB denotes improve
T2423 1204-1207 DT denotes the
T2424 1208-1219 NN denotes progression
T2425 1220-1224 IN denotes from
T2426 1225-1234 NN denotes candidate
T2427 1235-1240 NN denotes locus
T2428 1241-1243 IN denotes to
T2429 1244-1253 NN denotes candidate
T2430 1254-1258 NN denotes gene
T2431 1258-1259 . denotes .
R445 T2203 T2204 nsubj We,utilized
R446 T2205 T2204 aux have,utilized
R447 T2206 T2207 det the,mouse
R448 T2207 T2204 dobj mouse,utilized
R449 T2208 T2204 prep as,utilized
R450 T2209 T2210 det a,system
R451 T2210 T2208 pobj system,as
R452 T2211 T2210 compound model,system
R453 T2212 T2213 aux to,study
R454 T2213 T2204 advcl study,utilized
R455 T2214 T2215 det the,genetics
R456 T2215 T2213 dobj genetics,study
R457 T2216 T2215 prep of,genetics
R458 T2217 T2218 amod metabolic,diseases
R459 T2218 T2216 pobj diseases,of
R460 T2219 T2217 cc and,metabolic
R461 T2220 T2217 conj vascular,metabolic
R462 T2221 T2222 punct [,3
R463 T2222 T2204 parataxis 3,utilized
R464 T2223 T2224 punct –,5
R465 T2224 T2222 prep 5,3
R466 T2225 T2222 punct ],3
R467 T2226 T2204 punct .,utilized
R468 T2228 T2229 advmod Rather,utilize
R469 T2230 T2231 mark than,focus
R470 T2231 T2228 advcl focus,Rather
R471 T2232 T2231 advmod initially,focus
R472 T2233 T2231 prep on,focus
R473 T2234 T2235 amod natural,mutants
R474 T2235 T2233 pobj mutants,on
R475 T2236 T2234 cc or,natural
R476 T2237 T2234 conj induced,natural
R477 T2238 T2235 prep of,mutants
R478 T2239 T2240 amod single,genes
R479 T2240 T2238 pobj genes,of
R480 T2241 T2229 punct ", ",utilize
R481 T2242 T2229 nsubj we,utilize
R482 T2243 T2244 det the,variation
R483 T2244 T2229 dobj variation,utilize
R484 T2245 T2244 amod complex,variation
R485 T2246 T2244 amod endogenous,variation
R486 T2247 T2244 amod genetic,variation
R487 T2248 T2244 prep between,variation
R488 T2249 T2248 pobj strains,between
R489 T2250 T2249 prep in,strains
R490 T2251 T2252 amod genetic,crosses
R491 T2252 T2250 pobj crosses,in
R492 T2253 T2254 aux to,identify
R493 T2254 T2229 advcl identify,utilize
R494 T2255 T2256 amod causative,loci
R495 T2256 T2254 dobj loci,identify
R496 T2257 T2256 amod genetic,loci
R497 T2258 T2256 cc and,loci
R498 T2259 T2260 advmod ultimately,variations
R499 T2260 T2256 conj variations,loci
R500 T2261 T2260 det the,variations
R501 T2262 T2260 amod underlying,variations
R502 T2263 T2260 amod responsible,variations
R503 T2264 T2263 prep for,responsible
R504 T2265 T2266 compound trait,differences
R505 T2266 T2264 pobj differences,for
R506 T2267 T2268 punct [,6
R507 T2268 T2229 parataxis 6,utilize
R508 T2269 T2268 punct ],6
R509 T2270 T2229 punct .,utilize
R510 T2272 T2273 det This,design
R511 T2273 T2274 nsubj design,reflects
R512 T2275 T2276 advmod more,closely
R513 T2276 T2274 advmod closely,reflects
R514 T2277 T2278 det the,situation
R515 T2278 T2274 dobj situation,reflects
R516 T2279 T2278 acl faced,situation
R517 T2280 T2281 advmod when,studying
R518 T2281 T2279 advcl studying,faced
R519 T2282 T2283 amod human,populations
R520 T2283 T2281 dobj populations,studying
R521 T2284 T2274 punct .,reflects
R522 T2286 T2287 det The,composition
R523 T2287 T2289 nsubjpass composition,restricted
R524 T2288 T2287 amod genetic,composition
R525 T2290 T2287 prep of,composition
R526 T2291 T2292 det each,mouse
R527 T2292 T2290 pobj mouse,of
R528 T2293 T2292 amod individual,mouse
R529 T2294 T2289 auxpass is,restricted
R530 T2295 T2289 prep to,restricted
R531 T2296 T2295 pobj that,to
R532 T2297 T2296 prep of,that
R533 T2298 T2299 det the,strains
R534 T2299 T2297 pobj strains,of
R535 T2300 T2299 nummod two,strains
R536 T2301 T2299 amod parental,strains
R537 T2302 T2289 cc and,restricted
R538 T2303 T2304 auxpass is,defined
R539 T2304 T2289 conj defined,restricted
R540 T2305 T2304 prep at,defined
R541 T2306 T2307 det every,locus
R542 T2307 T2305 pobj locus,at
R543 T2308 T2307 prep across,locus
R544 T2309 T2310 det the,genome
R545 T2310 T2308 pobj genome,across
R546 T2311 T2289 punct .,restricted
R547 T2313 T2314 det The,application
R548 T2314 T2315 nsubj application,allows
R549 T2316 T2314 prep of,application
R550 T2317 T2318 amod quantitative,trait
R551 T2318 T2319 nmod trait,locus
R552 T2319 T2320 nmod locus,analysis
R553 T2320 T2316 pobj analysis,of
R554 T2321 T2319 punct (,locus
R555 T2322 T2319 appos QTL,locus
R556 T2323 T2320 punct ),analysis
R557 T2324 T2325 det the,identification
R558 T2325 T2315 dobj identification,allows
R559 T2326 T2325 prep of,identification
R560 T2327 T2328 det those,regions
R561 T2328 T2326 pobj regions,of
R562 T2329 T2328 amod chromosomal,regions
R563 T2330 T2331 dep that,contain
R564 T2331 T2328 relcl contain,regions
R565 T2332 T2333 det a,variation
R566 T2333 T2331 dobj variation,contain
R567 T2334 T2333 amod genetic,variation
R568 T2335 T2336 dep that,influences
R569 T2336 T2333 relcl influences,variation
R570 T2337 T2338 compound trait,expression
R571 T2338 T2336 dobj expression,influences
R572 T2339 T2340 punct (,see
R573 T2340 T2315 parataxis see,allows
R574 T2341 T2340 prep for,see
R575 T2342 T2343 det a,review
R576 T2343 T2341 pobj review,for
R577 T2344 T2343 amod comprehensive,review
R578 T2345 T2343 prep on,review
R579 T2346 T2345 pobj QTLs,on
R580 T2347 T2340 punct [,see
R581 T2348 T2340 dobj 7,see
R582 T2349 T2340 punct ],see
R583 T2350 T2340 punct ),see
R584 T2351 T2315 punct .,allows
R585 T2353 T2354 nsubj We,extended
R586 T2355 T2356 punct [,8
R587 T2356 T2353 parataxis 8,We
R588 T2357 T2356 nummod 5,8
R589 T2358 T2356 punct ",",8
R590 T2359 T2356 punct ],8
R591 T2360 T2353 punct ", ",We
R592 T2361 T2353 cc and,We
R593 T2362 T2353 conj others,We
R594 T2363 T2364 punct [,9
R595 T2364 T2362 parataxis 9,others
R596 T2365 T2366 punct –,17
R597 T2366 T2364 prep 17,9
R598 T2367 T2364 punct ],9
R599 T2368 T2354 punct ", ",extended
R600 T2369 T2354 aux have,extended
R601 T2370 T2354 advmod recently,extended
R602 T2371 T2372 det the,power
R603 T2372 T2354 dobj power,extended
R604 T2373 T2372 prep of,power
R605 T2374 T2375 det this,approach
R606 T2375 T2373 pobj approach,of
R607 T2376 T2354 prep by,extended
R608 T2377 T2376 pcomp incorporating,by
R609 T2378 T2379 npadvmod genome,wide
R610 T2379 T2381 amod wide,analysis
R611 T2380 T2379 punct -,wide
R612 T2381 T2377 dobj analysis,incorporating
R613 T2382 T2383 compound gene,expression
R614 T2383 T2381 compound expression,analysis
R615 T2384 T2381 compound array,analysis
R616 T2385 T2381 punct ", ",analysis
R617 T2386 T2387 dep which,allows
R618 T2387 T2381 relcl allows,analysis
R619 T2388 T2389 nsubj us,model
R620 T2389 T2387 ccomp model,allows
R621 T2390 T2389 aux to,model
R622 T2391 T2392 det the,genetics
R623 T2392 T2389 dobj genetics,model
R624 T2393 T2392 punct “,genetics
R625 T2394 T2392 prep of,genetics
R626 T2395 T2396 compound gene,expression
R627 T2396 T2394 pobj expression,of
R628 T2397 T2389 punct ”,model
R629 T2398 T2389 advcl using,model
R630 T2399 T2400 amod similar,methods
R631 T2400 T2398 dobj methods,using
R632 T2401 T2354 punct .,extended
R633 T2403 T2404 det An,extension
R634 T2404 T2406 nsubj extension,is
R635 T2405 T2404 amod immediate,extension
R636 T2407 T2404 prep of,extension
R637 T2408 T2409 det this,approach
R638 T2409 T2407 pobj approach,of
R639 T2410 T2406 prep toward,is
R640 T2411 T2410 pcomp dissecting,toward
R641 T2412 T2413 det the,regulation
R643 T2413 T2411 dobj regulation,dissecting
R645 T2414 T2413 amod genetic,regulation
R648 T2415 T2413 prep of,regulation
R651 T2416 T2417 amod complex,phenotypes
R655 T2417 T2415 pobj phenotypes,of
R659 T2418 T2413 punct ", ",regulation
R663 T2419 T2420 dep which,improve
R669 T2420 T2413 relcl improve,regulation
R673 T2421 T2420 aux would,improve
R677 T2422 T2420 advmod greatly,improve
R682 T2423 T2424 det the,progression
R683 T2424 T2420 dobj progression,improve
R686 T2425 T2424 prep from,progression
R690 T2426 T2427 compound candidate,locus
R694 T2427 T2425 pobj locus,from
R698 T2428 T2424 prep to,progression
R701 T2429 T2430 compound candidate,gene
R705 T2430 T2428 pobj gene,to
R709 T2431 T2406 punct .,is