craft-sa-dev Home  

PMC:1359071 / 36649-37780 JSONTXT 3 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T17058 0-2 PRP denotes We
T17059 3-11 VBD denotes reported
T17060 12-16 RB denotes here
T17061 17-19 IN denotes on
T17062 20-23 DT denotes the
T17064 24-31 JJ denotes initial
T17065 32-39 JJ denotes genetic
T17066 40-43 CC denotes and
T17067 44-51 JJ denotes genomic
T17063 52-60 NN denotes analysis
T17068 61-63 IN denotes of
T17069 64-66 DT denotes an
T17071 67-69 NN denotes F2
T17072 70-80 NN denotes intercross
T17070 81-91 NN denotes population
T17073 92-100 VBN denotes designed
T17074 101-103 TO denotes to
T17075 104-116 VB denotes recapitulate
T17076 117-124 JJ denotes several
T17077 125-131 NNS denotes traits
T17078 132-142 VBN denotes associated
T17079 143-147 IN denotes with
T17080 148-153 JJ denotes human
T17082 154-163 JJ denotes metabolic
T17081 164-172 NN denotes syndrome
T17083 172-173 . denotes .
T17084 173-380 sentence denotes Using 334 mice of both sexes genotyped at high density, this is the largest study of its kind to date designed, and it is strongly powered to detect subtle effects of genetic regulation and sex specificity.
T17085 174-179 VBG denotes Using
T17087 180-183 CD denotes 334
T17088 184-188 NNS denotes mice
T17089 189-191 IN denotes of
T17090 192-196 DT denotes both
T17091 197-202 NNS denotes sexes
T17092 203-212 VBN denotes genotyped
T17093 213-215 IN denotes at
T17094 216-220 JJ denotes high
T17095 221-228 NN denotes density
T17096 228-230 , denotes ,
T17097 230-234 DT denotes this
T17086 235-237 VBZ denotes is
T17098 238-241 DT denotes the
T17100 242-249 JJS denotes largest
T17099 250-255 NN denotes study
T17101 256-258 IN denotes of
T17102 259-262 PRP$ denotes its
T17103 263-267 NN denotes kind
T17104 268-270 IN denotes to
T17105 271-275 NN denotes date
T17106 276-284 VBN denotes designed
T17107 284-286 , denotes ,
T17108 286-289 CC denotes and
T17109 290-292 PRP denotes it
T17111 293-295 VBZ denotes is
T17112 296-304 RB denotes strongly
T17110 305-312 VBN denotes powered
T17113 313-315 TO denotes to
T17114 316-322 VB denotes detect
T17115 323-329 JJ denotes subtle
T17116 330-337 NNS denotes effects
T17117 338-340 IN denotes of
T17118 341-348 JJ denotes genetic
T17119 349-359 NN denotes regulation
T17120 360-363 CC denotes and
T17121 364-367 NN denotes sex
T17122 368-379 NN denotes specificity
T17123 379-380 . denotes .
T17124 380-474 sentence denotes We identified five cQTLs for the gonadal fat mass trait, all with greater effects in females.
T17125 381-383 PRP denotes We
T17126 384-394 VBD denotes identified
T17127 395-399 CD denotes five
T17128 400-405 NNS denotes cQTLs
T17129 406-409 IN denotes for
T17130 410-413 DT denotes the
T17132 414-421 JJ denotes gonadal
T17134 422-425 NN denotes fat
T17133 426-430 NN denotes mass
T17131 431-436 NN denotes trait
T17135 436-438 , denotes ,
T17136 438-441 DT denotes all
T17137 442-446 IN denotes with
T17138 447-454 JJR denotes greater
T17139 455-462 NNS denotes effects
T17140 463-465 IN denotes in
T17141 466-473 NNS denotes females
T17142 473-474 . denotes .
T17143 474-684 sentence denotes We also detected several thousand significant liver eQTLs, a significant fraction of which are sex-biased, demonstrating how meaningful effects of sex on gene expression extend beyond overall mean differences.
T17144 475-477 PRP denotes We
T17146 478-482 RB denotes also
T17145 483-491 VBD denotes detected
T17147 492-499 JJ denotes several
T17148 500-508 CD denotes thousand
T17150 509-520 JJ denotes significant
T17151 521-526 NN denotes liver
T17149 527-532 NNS denotes eQTLs
T17152 532-534 , denotes ,
T17153 534-535 DT denotes a
T17155 536-547 JJ denotes significant
T17154 548-556 NN denotes fraction
T17157 557-559 IN denotes of
T17158 560-565 WDT denotes which
T17156 566-569 VBP denotes are
T17159 570-573 NN denotes sex
T17161 573-574 HYPH denotes -
T17160 574-580 VBN denotes biased
T17162 580-582 , denotes ,
T17163 582-595 VBG denotes demonstrating
T17164 596-599 WRB denotes how
T17166 600-610 JJ denotes meaningful
T17167 611-618 NNS denotes effects
T17168 619-621 IN denotes of
T17169 622-625 NN denotes sex
T17170 626-628 IN denotes on
T17171 629-633 NN denotes gene
T17172 634-644 NN denotes expression
T17165 645-651 VBP denotes extend
T17173 652-658 IN denotes beyond
T17174 659-666 JJ denotes overall
T17176 667-671 NN denotes mean
T17175 672-683 NNS denotes differences
T17177 683-684 . denotes .
T17178 684-780 sentence denotes We demonstrated the application of linkage and correlation methods to identify candidate genes.
T17179 685-687 PRP denotes We
T17180 688-700 VBD denotes demonstrated
T17181 701-704 DT denotes the
T17182 705-716 NN denotes application
T17183 717-719 IN denotes of
T17184 720-727 NN denotes linkage
T17186 728-731 CC denotes and
T17187 732-743 NN denotes correlation
T17185 744-751 NNS denotes methods
T17188 752-754 TO denotes to
T17189 755-763 VB denotes identify
T17190 764-773 NN denotes candidate
T17191 774-779 NNS denotes genes
T17192 779-780 . denotes .
T17193 780-966 sentence denotes Finally, we showed that localization of a subset of liver genes linked in trans to a cQTL region can identify relative tissue contributions to the genetic regulation of a complex trait.
T17194 781-788 RB denotes Finally
T17196 788-790 , denotes ,
T17197 790-792 PRP denotes we
T17195 793-799 VBD denotes showed
T17198 800-804 IN denotes that
T17200 805-817 NN denotes localization
T17201 818-820 IN denotes of
T17202 821-822 DT denotes a
T17203 823-829 NN denotes subset
T17204 830-832 IN denotes of
T17205 833-838 NN denotes liver
T17206 839-844 NNS denotes genes
T17207 845-851 VBN denotes linked
T17208 852-854 IN denotes in
T17209 855-860 NN denotes trans
T17210 861-863 IN denotes to
T17211 864-865 DT denotes a
T17213 866-870 NN denotes cQTL
T17212 871-877 NN denotes region
T17214 878-881 MD denotes can
T17199 882-890 VB denotes identify
T17215 891-899 JJ denotes relative
T17217 900-906 NN denotes tissue
T17216 907-920 NNS denotes contributions
T17218 921-923 IN denotes to
T17219 924-927 DT denotes the
T17221 928-935 JJ denotes genetic
T17220 936-946 NN denotes regulation
T17222 947-949 IN denotes of
T17223 950-951 DT denotes a
T17225 952-959 JJ denotes complex
T17224 960-965 NN denotes trait
T17226 965-966 . denotes .
T17227 966-1131 sentence denotes We anticipate that the application of these and similar methods would significantly improve the elucidation of the genetic regulation underlying complex phenotypes.
T17228 967-969 PRP denotes We
T17229 970-980 VBP denotes anticipate
T17230 981-985 IN denotes that
T17232 986-989 DT denotes the
T17233 990-1001 NN denotes application
T17234 1002-1004 IN denotes of
T17235 1005-1010 DT denotes these
T17237 1011-1014 CC denotes and
T17236 1015-1022 JJ denotes similar
T17238 1023-1030 NNS denotes methods
T17239 1031-1036 MD denotes would
T17240 1037-1050 RB denotes significantly
T17231 1051-1058 VB denotes improve
T17241 1059-1062 DT denotes the
T17242 1063-1074 NN denotes elucidation
T17243 1075-1077 IN denotes of
T17244 1078-1081 DT denotes the
T17246 1082-1089 JJ denotes genetic
T17245 1090-1100 NN denotes regulation
T17247 1101-1111 VBG denotes underlying
T17248 1112-1119 JJ denotes complex
T17249 1120-1130 NNS denotes phenotypes
T17250 1130-1131 . denotes .
R5357 T17058 T17059 nsubj We,reported
R5358 T17060 T17059 advmod here,reported
R5359 T17061 T17059 prep on,reported
R5360 T17062 T17063 det the,analysis
R5361 T17063 T17061 pobj analysis,on
R5362 T17064 T17063 amod initial,analysis
R5363 T17065 T17063 amod genetic,analysis
R5364 T17066 T17065 cc and,genetic
R5365 T17067 T17065 conj genomic,genetic
R5366 T17068 T17063 prep of,analysis
R5367 T17069 T17070 det an,population
R5368 T17070 T17068 pobj population,of
R5369 T17071 T17072 compound F2,intercross
R5370 T17072 T17070 compound intercross,population
R5371 T17073 T17070 acl designed,population
R5372 T17074 T17075 aux to,recapitulate
R5373 T17075 T17073 xcomp recapitulate,designed
R5374 T17076 T17077 amod several,traits
R5375 T17077 T17075 dobj traits,recapitulate
R5376 T17078 T17077 acl associated,traits
R5377 T17079 T17078 prep with,associated
R5378 T17080 T17081 amod human,syndrome
R5379 T17081 T17079 pobj syndrome,with
R5380 T17082 T17081 amod metabolic,syndrome
R5381 T17083 T17059 punct .,reported
R5382 T17085 T17086 advcl Using,is
R5383 T17087 T17088 nummod 334,mice
R5384 T17088 T17085 dobj mice,Using
R5385 T17089 T17088 prep of,mice
R5386 T17090 T17091 det both,sexes
R5387 T17091 T17089 pobj sexes,of
R5388 T17092 T17088 acl genotyped,mice
R5389 T17093 T17092 prep at,genotyped
R5390 T17094 T17095 amod high,density
R5391 T17095 T17093 pobj density,at
R5392 T17096 T17086 punct ", ",is
R5393 T17097 T17086 nsubj this,is
R5394 T17098 T17099 det the,study
R5395 T17099 T17086 attr study,is
R5396 T17100 T17099 amod largest,study
R5397 T17101 T17099 prep of,study
R5398 T17102 T17103 poss its,kind
R5399 T17103 T17101 pobj kind,of
R5400 T17104 T17099 prep to,study
R5401 T17105 T17104 pobj date,to
R5402 T17106 T17099 acl designed,study
R5403 T17107 T17086 punct ", ",is
R5404 T17108 T17086 cc and,is
R5405 T17109 T17110 nsubjpass it,powered
R5406 T17110 T17086 conj powered,is
R5407 T17111 T17110 auxpass is,powered
R5408 T17112 T17110 advmod strongly,powered
R5409 T17113 T17114 aux to,detect
R5410 T17114 T17110 xcomp detect,powered
R5411 T17115 T17116 amod subtle,effects
R5412 T17116 T17114 dobj effects,detect
R5413 T17117 T17116 prep of,effects
R5414 T17118 T17119 amod genetic,regulation
R5415 T17119 T17117 pobj regulation,of
R5416 T17120 T17119 cc and,regulation
R5417 T17121 T17122 compound sex,specificity
R5418 T17122 T17119 conj specificity,regulation
R5419 T17123 T17110 punct .,powered
R5420 T17125 T17126 nsubj We,identified
R5421 T17127 T17128 nummod five,cQTLs
R5422 T17128 T17126 dobj cQTLs,identified
R5423 T17129 T17128 prep for,cQTLs
R5424 T17130 T17131 det the,trait
R5425 T17131 T17129 pobj trait,for
R5426 T17132 T17133 amod gonadal,mass
R5427 T17133 T17131 compound mass,trait
R5428 T17134 T17133 compound fat,mass
R5429 T17135 T17128 punct ", ",cQTLs
R5430 T17136 T17128 appos all,cQTLs
R5431 T17137 T17136 prep with,all
R5432 T17138 T17139 amod greater,effects
R5433 T17139 T17137 pobj effects,with
R5434 T17140 T17139 prep in,effects
R5435 T17141 T17140 pobj females,in
R5436 T17142 T17126 punct .,identified
R5437 T17144 T17145 nsubj We,detected
R5438 T17146 T17145 advmod also,detected
R5439 T17147 T17148 amod several,thousand
R5440 T17148 T17149 nummod thousand,eQTLs
R5441 T17149 T17145 dobj eQTLs,detected
R5442 T17150 T17149 amod significant,eQTLs
R5443 T17151 T17149 compound liver,eQTLs
R5444 T17152 T17149 punct ", ",eQTLs
R5445 T17153 T17154 det a,fraction
R5446 T17154 T17156 dep fraction,are
R5447 T17155 T17154 amod significant,fraction
R5448 T17156 T17149 relcl are,eQTLs
R5449 T17157 T17154 prep of,fraction
R5450 T17158 T17157 pobj which,of
R5451 T17159 T17160 npadvmod sex,biased
R5452 T17160 T17156 acomp biased,are
R5453 T17161 T17160 punct -,biased
R5454 T17162 T17156 punct ", ",are
R5455 T17163 T17156 advcl demonstrating,are
R5456 T17164 T17165 advmod how,extend
R5457 T17165 T17163 ccomp extend,demonstrating
R5458 T17166 T17167 amod meaningful,effects
R5459 T17167 T17165 nsubj effects,extend
R5460 T17168 T17167 prep of,effects
R5461 T17169 T17168 pobj sex,of
R5462 T17170 T17167 prep on,effects
R5463 T17171 T17172 compound gene,expression
R5464 T17172 T17170 pobj expression,on
R5465 T17173 T17165 prep beyond,extend
R5466 T17174 T17175 amod overall,differences
R5467 T17175 T17173 pobj differences,beyond
R5468 T17176 T17175 compound mean,differences
R5469 T17177 T17145 punct .,detected
R5470 T17179 T17180 nsubj We,demonstrated
R5471 T17181 T17182 det the,application
R5472 T17182 T17180 dobj application,demonstrated
R5473 T17183 T17182 prep of,application
R5474 T17184 T17185 nmod linkage,methods
R5475 T17185 T17183 pobj methods,of
R5476 T17186 T17184 cc and,linkage
R5477 T17187 T17184 conj correlation,linkage
R5478 T17188 T17189 aux to,identify
R5479 T17189 T17182 acl identify,application
R5480 T17190 T17191 compound candidate,genes
R5481 T17191 T17189 dobj genes,identify
R5482 T17192 T17180 punct .,demonstrated
R5483 T17194 T17195 advmod Finally,showed
R5484 T17196 T17195 punct ", ",showed
R5485 T17197 T17195 nsubj we,showed
R5486 T17198 T17199 mark that,identify
R5487 T17199 T17195 ccomp identify,showed
R5488 T17200 T17199 nsubj localization,identify
R5489 T17201 T17200 prep of,localization
R5490 T17202 T17203 det a,subset
R5491 T17203 T17201 pobj subset,of
R5492 T17204 T17203 prep of,subset
R5493 T17205 T17206 compound liver,genes
R5494 T17206 T17204 pobj genes,of
R5495 T17207 T17206 acl linked,genes
R5496 T17208 T17207 prep in,linked
R5497 T17209 T17208 pobj trans,in
R5498 T17210 T17207 prep to,linked
R5499 T17211 T17212 det a,region
R5500 T17212 T17210 pobj region,to
R5501 T17213 T17212 compound cQTL,region
R5502 T17214 T17199 aux can,identify
R5503 T17215 T17216 amod relative,contributions
R5504 T17216 T17199 dobj contributions,identify
R5505 T17217 T17216 compound tissue,contributions
R5506 T17218 T17216 prep to,contributions
R5507 T17219 T17220 det the,regulation
R5508 T17220 T17218 pobj regulation,to
R5509 T17221 T17220 amod genetic,regulation
R5510 T17222 T17220 prep of,regulation
R5511 T17223 T17224 det a,trait
R5512 T17224 T17222 pobj trait,of
R5513 T17225 T17224 amod complex,trait
R5514 T17226 T17195 punct .,showed
R5515 T17228 T17229 nsubj We,anticipate
R5516 T17230 T17231 mark that,improve
R5517 T17231 T17229 ccomp improve,anticipate
R5518 T17232 T17233 det the,application
R5519 T17233 T17231 nsubj application,improve
R5520 T17234 T17233 prep of,application
R5521 T17235 T17236 advmod these,similar
R5522 T17236 T17238 amod similar,methods
R5523 T17237 T17236 cc and,similar
R5524 T17238 T17234 pobj methods,of
R5525 T17239 T17231 aux would,improve
R5526 T17240 T17231 advmod significantly,improve
R5527 T17241 T17242 det the,elucidation
R5528 T17242 T17231 dobj elucidation,improve
R5529 T17243 T17242 prep of,elucidation
R5530 T17244 T17245 det the,regulation
R5531 T17245 T17243 pobj regulation,of
R5532 T17246 T17245 amod genetic,regulation
R5533 T17247 T17245 acl underlying,regulation
R5534 T17248 T17249 amod complex,phenotypes
R5535 T17249 T17247 dobj phenotypes,underlying
R5536 T17250 T17229 punct .,anticipate