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PMC:1359071 / 33165-35740 JSONTXT 4 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T15737 0-5 NNS denotes Genes
T15739 6-16 VBN denotes Correlated
T15740 17-21 IN denotes with
T15741 22-29 JJ denotes Gonadal
T15743 30-33 NN denotes Fat
T15742 34-38 NN denotes Mass
T15738 39-49 VBP denotes Illustrate
T15744 50-56 NN denotes Tissue
T15746 56-57 HYPH denotes -
T15745 57-65 JJ denotes Specific
T15747 66-76 NN denotes Regulation
T15748 77-79 IN denotes of
T15749 80-83 DT denotes the
T15750 84-89 NN denotes Trait
T15751 89-322 sentence denotes In an effort to identify genes associated with the fat mass trait, but not necessarily candidate genes underlying the trait cQTLs, we fitted linear models to assess the degree of association between transcripts and gonadal fat mass.
T15752 90-92 IN denotes In
T15754 93-95 DT denotes an
T15755 96-102 NN denotes effort
T15756 103-105 TO denotes to
T15757 106-114 VB denotes identify
T15758 115-120 NNS denotes genes
T15759 121-131 VBN denotes associated
T15760 132-136 IN denotes with
T15761 137-140 DT denotes the
T15763 141-144 NN denotes fat
T15764 145-149 NN denotes mass
T15762 150-155 NN denotes trait
T15765 155-157 , denotes ,
T15766 157-160 CC denotes but
T15767 161-164 RB denotes not
T15768 165-176 RB denotes necessarily
T15770 177-186 NN denotes candidate
T15769 187-192 NNS denotes genes
T15771 193-203 VBG denotes underlying
T15772 204-207 DT denotes the
T15774 208-213 NN denotes trait
T15773 214-219 NNS denotes cQTLs
T15775 219-221 , denotes ,
T15776 221-223 PRP denotes we
T15753 224-230 VBD denotes fitted
T15777 231-237 JJ denotes linear
T15778 238-244 NNS denotes models
T15779 245-247 TO denotes to
T15780 248-254 VB denotes assess
T15781 255-258 DT denotes the
T15782 259-265 NN denotes degree
T15783 266-268 IN denotes of
T15784 269-280 NN denotes association
T15785 281-288 IN denotes between
T15786 289-300 NNS denotes transcripts
T15787 301-304 CC denotes and
T15788 305-312 JJ denotes gonadal
T15790 313-316 NN denotes fat
T15789 317-321 NN denotes mass
T15791 321-322 . denotes .
T15792 322-376 sentence denotes As with QTLs, sex-specific correlations were modeled.
T15793 323-325 IN denotes As
T15795 326-330 IN denotes with
T15796 331-335 NNS denotes QTLs
T15797 335-337 , denotes ,
T15798 337-340 NN denotes sex
T15800 340-341 HYPH denotes -
T15799 341-349 JJ denotes specific
T15801 350-362 NNS denotes correlations
T15802 363-367 VBD denotes were
T15794 368-375 VBN denotes modeled
T15803 375-376 . denotes .
T15804 376-522 sentence denotes At an FDR of 1%, 4,613 genes were found to be significantly correlated with gonadal fat mass, of which 4,254 (98%) showed sex-biased correlation.
T15805 377-379 IN denotes At
T15807 380-382 DT denotes an
T15808 383-386 NN denotes FDR
T15809 387-389 IN denotes of
T15810 390-391 CD denotes 1
T15811 391-392 NN denotes %
T15812 392-394 , denotes ,
T15813 394-399 CD denotes 4,613
T15814 400-405 NNS denotes genes
T15815 406-410 VBD denotes were
T15806 411-416 VBN denotes found
T15816 417-419 TO denotes to
T15818 420-422 VB denotes be
T15819 423-436 RB denotes significantly
T15817 437-447 VBN denotes correlated
T15820 448-452 IN denotes with
T15821 453-460 JJ denotes gonadal
T15823 461-464 NN denotes fat
T15822 465-469 NN denotes mass
T15824 469-471 , denotes ,
T15825 471-473 IN denotes of
T15827 474-479 WDT denotes which
T15828 480-485 CD denotes 4,254
T15829 486-487 -LRB- denotes (
T15831 487-489 CD denotes 98
T15830 489-490 NN denotes %
T15832 490-491 -RRB- denotes )
T15826 492-498 VBD denotes showed
T15833 499-502 NN denotes sex
T15835 502-503 HYPH denotes -
T15834 503-509 VBN denotes biased
T15836 510-521 NN denotes correlation
T15837 521-522 . denotes .
T15838 522-696 sentence denotes As indicated in Tables 4 and 5, several genes with detectable cis-eQTLs are also significantly correlated with the trait and are even further prioritized as candidate genes.
T15839 523-525 IN denotes As
T15840 526-535 VBN denotes indicated
T15842 536-538 IN denotes in
T15843 539-545 NNS denotes Tables
T15844 546-547 CD denotes 4
T15845 548-551 CC denotes and
T15846 552-553 CD denotes 5
T15847 553-555 , denotes ,
T15848 555-562 JJ denotes several
T15849 563-568 NNS denotes genes
T15850 569-573 IN denotes with
T15851 574-584 JJ denotes detectable
T15853 585-588 NN denotes cis
T15854 588-589 HYPH denotes -
T15852 589-594 NNS denotes eQTLs
T15855 595-598 VBP denotes are
T15856 599-603 RB denotes also
T15857 604-617 RB denotes significantly
T15841 618-628 VBN denotes correlated
T15858 629-633 IN denotes with
T15859 634-637 DT denotes the
T15860 638-643 NN denotes trait
T15861 644-647 CC denotes and
T15862 648-651 VBP denotes are
T15864 652-656 RB denotes even
T15865 657-664 RB denotes further
T15863 665-676 VBN denotes prioritized
T15866 677-679 IN denotes as
T15867 680-689 NN denotes candidate
T15868 690-695 NNS denotes genes
T15869 695-696 . denotes .
T15870 696-873 sentence denotes Thus far, studies that have examined the “genetics of gene expression” are in good agreement regarding the increased power to detect cis-eQTLs relative to trans [5,9,15,16,31].
T15871 697-701 RB denotes Thus
T15872 702-705 RB denotes far
T15874 705-707 , denotes ,
T15875 707-714 NNS denotes studies
T15876 715-719 WDT denotes that
T15878 720-724 VBP denotes have
T15877 725-733 VBN denotes examined
T15879 734-737 DT denotes the
T15881 738-739 `` denotes “
T15880 739-747 NN denotes genetics
T15882 748-750 IN denotes of
T15883 751-755 NN denotes gene
T15884 756-766 NN denotes expression
T15885 766-767 '' denotes ”
T15873 768-771 VBP denotes are
T15886 772-774 IN denotes in
T15887 775-779 JJ denotes good
T15888 780-789 NN denotes agreement
T15889 790-799 VBG denotes regarding
T15890 800-803 DT denotes the
T15892 804-813 VBN denotes increased
T15891 814-819 NN denotes power
T15893 820-822 TO denotes to
T15894 823-829 VB denotes detect
T15895 830-833 NN denotes cis
T15897 833-834 HYPH denotes -
T15896 834-839 NNS denotes eQTLs
T15898 840-848 JJ denotes relative
T15899 849-851 IN denotes to
T15900 852-857 NN denotes trans
T15901 858-859 -LRB- denotes [
T15903 859-860 CD denotes 5
T15904 860-861 , denotes ,
T15905 861-862 CD denotes 9
T15906 862-863 , denotes ,
T15907 863-865 CD denotes 15
T15908 865-866 , denotes ,
T15909 866-868 CD denotes 16
T15910 868-869 , denotes ,
T15902 869-871 CD denotes 31
T15911 871-872 -RRB- denotes ]
T15912 872-873 . denotes .
T15913 873-1027 sentence denotes It is unclear at this time, however, what exactly is the significance of trans-eQTLs and the nature of the underlying polymorphisms associated with them.
T15914 874-876 PRP denotes It
T15915 877-879 VBZ denotes is
T15916 880-887 JJ denotes unclear
T15917 888-890 IN denotes at
T15918 891-895 DT denotes this
T15919 896-900 NN denotes time
T15920 900-902 , denotes ,
T15921 902-909 RB denotes however
T15922 909-911 , denotes ,
T15923 911-915 WP denotes what
T15925 916-923 RB denotes exactly
T15924 924-926 VBZ denotes is
T15926 927-930 DT denotes the
T15927 931-943 NN denotes significance
T15928 944-946 IN denotes of
T15929 947-952 NN denotes trans
T15931 952-953 HYPH denotes -
T15930 953-958 NNS denotes eQTLs
T15932 959-962 CC denotes and
T15933 963-966 DT denotes the
T15934 967-973 NN denotes nature
T15935 974-976 IN denotes of
T15936 977-980 DT denotes the
T15938 981-991 VBG denotes underlying
T15937 992-1005 NNS denotes polymorphisms
T15939 1006-1016 VBN denotes associated
T15940 1017-1021 IN denotes with
T15941 1022-1026 PRP denotes them
T15942 1026-1027 . denotes .
T15943 1027-1136 sentence denotes Furthermore, the eQTL hotspots reported in this and previous studies [5,9,10] largely represent trans-eQTLs.
T15944 1028-1039 RB denotes Furthermore
T15946 1039-1041 , denotes ,
T15947 1041-1044 DT denotes the
T15949 1045-1049 NN denotes eQTL
T15948 1050-1058 NNS denotes hotspots
T15950 1059-1067 VBN denotes reported
T15951 1068-1070 IN denotes in
T15952 1071-1075 DT denotes this
T15954 1076-1079 CC denotes and
T15953 1080-1088 JJ denotes previous
T15955 1089-1096 NNS denotes studies
T15956 1097-1098 -LRB- denotes [
T15958 1098-1099 CD denotes 5
T15959 1099-1100 , denotes ,
T15960 1100-1101 CD denotes 9
T15961 1101-1102 , denotes ,
T15957 1102-1104 CD denotes 10
T15962 1104-1105 -RRB- denotes ]
T15963 1106-1113 RB denotes largely
T15945 1114-1123 VBP denotes represent
T15964 1124-1129 NN denotes trans
T15966 1129-1130 HYPH denotes -
T15965 1130-1135 NNS denotes eQTLs
T15967 1135-1136 . denotes .
T15968 1136-1210 sentence denotes This localization suggests some functional significance to these regions.
T15969 1137-1141 DT denotes This
T15970 1142-1154 NN denotes localization
T15971 1155-1163 VBZ denotes suggests
T15972 1164-1168 DT denotes some
T15974 1169-1179 JJ denotes functional
T15973 1180-1192 NN denotes significance
T15975 1193-1195 IN denotes to
T15976 1196-1201 DT denotes these
T15977 1202-1209 NNS denotes regions
T15978 1209-1210 . denotes .
T15979 1210-1342 sentence denotes Of the 4,613 genes correlated with gonadal fat mass, 1,130 generate 1,478 significant eQTLs, of which 1,023 (69%) are trans-acting.
T15980 1211-1213 IN denotes Of
T15982 1214-1217 DT denotes the
T15984 1218-1223 CD denotes 4,613
T15983 1224-1229 NNS denotes genes
T15985 1230-1240 VBN denotes correlated
T15986 1241-1245 IN denotes with
T15987 1246-1253 JJ denotes gonadal
T15989 1254-1257 NN denotes fat
T15988 1258-1262 NN denotes mass
T15990 1262-1264 , denotes ,
T15991 1264-1269 CD denotes 1,130
T15981 1270-1278 VBP denotes generate
T15992 1279-1284 CD denotes 1,478
T15994 1285-1296 JJ denotes significant
T15993 1297-1302 NNS denotes eQTLs
T15995 1302-1304 , denotes ,
T15996 1304-1306 IN denotes of
T15998 1307-1312 WDT denotes which
T15999 1313-1318 CD denotes 1,023
T16000 1319-1320 -LRB- denotes (
T16002 1320-1322 CD denotes 69
T16001 1322-1323 NN denotes %
T16003 1323-1324 -RRB- denotes )
T15997 1325-1328 VBP denotes are
T16004 1329-1334 NN denotes trans
T16006 1334-1335 HYPH denotes -
T16005 1335-1341 VBG denotes acting
T16007 1341-1342 . denotes .
T16008 1342-1411 sentence denotes These eQTLs are significantly enriched at one locus (Chromosome 19).
T16009 1343-1348 DT denotes These
T16010 1349-1354 NNS denotes eQTLs
T16012 1355-1358 VBP denotes are
T16013 1359-1372 RB denotes significantly
T16011 1373-1381 VBN denotes enriched
T16014 1382-1384 IN denotes at
T16015 1385-1388 CD denotes one
T16016 1389-1394 NN denotes locus
T16017 1395-1396 -LRB- denotes (
T16018 1396-1406 NN denotes Chromosome
T16019 1407-1409 CD denotes 19
T16020 1409-1410 -RRB- denotes )
T16021 1410-1411 . denotes .
T16022 1411-1515 sentence denotes Interestingly, this hotspot was coincident with a cQTL associated with fat mass reported in this study.
T16023 1412-1425 RB denotes Interestingly
T16025 1425-1427 , denotes ,
T16026 1427-1431 DT denotes this
T16027 1432-1439 NN denotes hotspot
T16024 1440-1443 VBD denotes was
T16028 1444-1454 JJ denotes coincident
T16029 1455-1459 IN denotes with
T16030 1460-1461 DT denotes a
T16031 1462-1466 NN denotes cQTL
T16032 1467-1477 VBN denotes associated
T16033 1478-1482 IN denotes with
T16034 1483-1486 NN denotes fat
T16035 1487-1491 NN denotes mass
T16036 1492-1500 VBN denotes reported
T16037 1501-1503 IN denotes in
T16038 1504-1508 DT denotes this
T16039 1509-1514 NN denotes study
T16040 1514-1515 . denotes .
T16041 1515-1820 sentence denotes Since these transcripts represent those significantly correlated with gonadal fat mass, the localization of their eQTLs to these regions strongly supports the notion that the genes with trans-eQTLs represent downstream targets of candidate regulatory genes located at the position of significant linkage.
T16042 1516-1521 IN denotes Since
T16044 1522-1527 DT denotes these
T16045 1528-1539 NNS denotes transcripts
T16043 1540-1549 VBP denotes represent
T16047 1550-1555 DT denotes those
T16048 1556-1569 RB denotes significantly
T16049 1570-1580 VBN denotes correlated
T16050 1581-1585 IN denotes with
T16051 1586-1593 JJ denotes gonadal
T16053 1594-1597 NN denotes fat
T16052 1598-1602 NN denotes mass
T16054 1602-1604 , denotes ,
T16055 1604-1607 DT denotes the
T16056 1608-1620 NN denotes localization
T16057 1621-1623 IN denotes of
T16058 1624-1629 PRP$ denotes their
T16059 1630-1635 NNS denotes eQTLs
T16060 1636-1638 IN denotes to
T16061 1639-1644 DT denotes these
T16062 1645-1652 NNS denotes regions
T16063 1653-1661 RB denotes strongly
T16046 1662-1670 VBZ denotes supports
T16064 1671-1674 DT denotes the
T16065 1675-1681 NN denotes notion
T16066 1682-1686 IN denotes that
T16068 1687-1690 DT denotes the
T16069 1691-1696 NNS denotes genes
T16070 1697-1701 IN denotes with
T16071 1702-1707 NN denotes trans
T16073 1707-1708 HYPH denotes -
T16072 1708-1713 NNS denotes eQTLs
T16067 1714-1723 VB denotes represent
T16074 1724-1734 JJ denotes downstream
T16075 1735-1742 NNS denotes targets
T16076 1743-1745 IN denotes of
T16077 1746-1755 NN denotes candidate
T16079 1756-1766 JJ denotes regulatory
T16078 1767-1772 NNS denotes genes
T16080 1773-1780 VBN denotes located
T16081 1781-1783 IN denotes at
T16082 1784-1787 DT denotes the
T16083 1788-1796 NN denotes position
T16084 1797-1799 IN denotes of
T16085 1800-1811 JJ denotes significant
T16086 1812-1819 NN denotes linkage
T16087 1819-1820 . denotes .
T16088 1820-2006 sentence denotes This means that the genes may be causal but downstream of the gene responsible for the cQTLs, or they may be reacting to the increased gonadal fat mass and associated metabolic changes.
T16089 1821-1825 DT denotes This
T16090 1826-1831 VBZ denotes means
T16091 1832-1836 IN denotes that
T16093 1837-1840 DT denotes the
T16094 1841-1846 NNS denotes genes
T16095 1847-1850 MD denotes may
T16092 1851-1853 VB denotes be
T16096 1854-1860 JJ denotes causal
T16097 1861-1864 CC denotes but
T16098 1865-1875 RB denotes downstream
T16099 1876-1878 IN denotes of
T16100 1879-1882 DT denotes the
T16101 1883-1887 NN denotes gene
T16102 1888-1899 JJ denotes responsible
T16103 1900-1903 IN denotes for
T16104 1904-1907 DT denotes the
T16105 1908-1913 NNS denotes cQTLs
T16106 1913-1915 , denotes ,
T16107 1915-1917 CC denotes or
T16108 1918-1922 PRP denotes they
T16110 1923-1926 MD denotes may
T16111 1927-1929 VB denotes be
T16109 1930-1938 VBG denotes reacting
T16112 1939-1941 IN denotes to
T16113 1942-1945 DT denotes the
T16115 1946-1955 VBN denotes increased
T16116 1956-1963 JJ denotes gonadal
T16117 1964-1967 NN denotes fat
T16114 1968-1972 NN denotes mass
T16118 1973-1976 CC denotes and
T16119 1977-1987 VBN denotes associated
T16121 1988-1997 JJ denotes metabolic
T16120 1998-2005 NNS denotes changes
T16122 2005-2006 . denotes .
T16123 2006-2211 sentence denotes These data also suggest that identifying such loci that show overrepresentation of highly correlated genes is a means to identify which of the trait cQTLs are more likely controlled by the tissue arrayed.
T16124 2007-2012 DT denotes These
T16125 2013-2017 NNS denotes data
T16127 2018-2022 RB denotes also
T16126 2023-2030 VBP denotes suggest
T16128 2031-2035 IN denotes that
T16130 2036-2047 VBG denotes identifying
T16131 2048-2052 JJ denotes such
T16132 2053-2057 NNS denotes loci
T16133 2058-2062 WDT denotes that
T16134 2063-2067 VBP denotes show
T16135 2068-2086 NN denotes overrepresentation
T16136 2087-2089 IN denotes of
T16137 2090-2096 RB denotes highly
T16138 2097-2107 VBN denotes correlated
T16139 2108-2113 NNS denotes genes
T16129 2114-2116 VBZ denotes is
T16140 2117-2118 DT denotes a
T16141 2119-2124 NN denotes means
T16142 2125-2127 TO denotes to
T16143 2128-2136 VB denotes identify
T16144 2137-2142 WDT denotes which
T16146 2143-2145 IN denotes of
T16147 2146-2149 DT denotes the
T16149 2150-2155 NN denotes trait
T16148 2156-2161 NNS denotes cQTLs
T16150 2162-2165 VBP denotes are
T16151 2166-2170 RBR denotes more
T16152 2171-2177 RB denotes likely
T16145 2178-2188 VBN denotes controlled
T16153 2189-2191 IN denotes by
T16154 2192-2195 DT denotes the
T16155 2196-2202 NN denotes tissue
T16156 2203-2210 VBN denotes arrayed
T16157 2210-2211 . denotes .
T16158 2211-2324 sentence denotes As expected, the Chromosome 19 locus was enriched for trans-eQTLs with substantially greater effects in females.
T16159 2212-2214 IN denotes As
T16160 2215-2223 VBN denotes expected
T16162 2223-2225 , denotes ,
T16163 2225-2228 DT denotes the
T16165 2229-2239 NN denotes Chromosome
T16166 2240-2242 CD denotes 19
T16164 2243-2248 NN denotes locus
T16161 2249-2252 VBD denotes was
T16167 2253-2261 JJ denotes enriched
T16168 2262-2265 IN denotes for
T16169 2266-2271 NN denotes trans
T16171 2271-2272 HYPH denotes -
T16170 2272-2277 NNS denotes eQTLs
T16172 2278-2282 IN denotes with
T16173 2283-2296 RB denotes substantially
T16174 2297-2304 JJR denotes greater
T16175 2305-2312 NNS denotes effects
T16176 2313-2315 IN denotes in
T16177 2316-2323 NNS denotes females
T16178 2323-2324 . denotes .
T16179 2324-2415 sentence denotes Functional and promoter analysis of genes with a common trans-eQTL may prove enlightening.
T16180 2325-2335 JJ denotes Functional
T16182 2336-2339 CC denotes and
T16183 2340-2348 NN denotes promoter
T16181 2349-2357 NN denotes analysis
T16185 2358-2360 IN denotes of
T16186 2361-2366 NNS denotes genes
T16187 2367-2371 IN denotes with
T16188 2372-2373 DT denotes a
T16190 2374-2380 JJ denotes common
T16191 2381-2386 NN denotes trans
T16192 2386-2387 HYPH denotes -
T16189 2387-2391 NN denotes eQTL
T16193 2392-2395 MD denotes may
T16184 2396-2401 VB denotes prove
T16194 2402-2414 JJ denotes enlightening
T16195 2414-2415 . denotes .
T16196 2415-2575 sentence denotes Furthermore, gene expression network construction and analysis may be improved by the incorporation of experimentally demonstrated cis versus trans regulation.
T16197 2416-2427 RB denotes Furthermore
T16199 2427-2429 , denotes ,
T16200 2429-2433 NN denotes gene
T16201 2434-2444 NN denotes expression
T16203 2445-2452 NN denotes network
T16202 2453-2465 NN denotes construction
T16204 2466-2469 CC denotes and
T16205 2470-2478 NN denotes analysis
T16206 2479-2482 MD denotes may
T16207 2483-2485 VB denotes be
T16198 2486-2494 VBN denotes improved
T16208 2495-2497 IN denotes by
T16209 2498-2501 DT denotes the
T16210 2502-2515 NN denotes incorporation
T16211 2516-2518 IN denotes of
T16212 2519-2533 RB denotes experimentally
T16213 2534-2546 VBN denotes demonstrated
T16215 2547-2550 NN denotes cis
T16217 2551-2557 IN denotes versus
T16216 2558-2563 NN denotes trans
T16214 2564-2574 NN denotes regulation
T16218 2574-2575 . denotes .
R4770 T15737 T15738 nsubj Genes,Illustrate
R4771 T15739 T15737 acl Correlated,Genes
R4772 T15740 T15739 prep with,Correlated
R4773 T15741 T15742 amod Gonadal,Mass
R4774 T15742 T15740 pobj Mass,with
R4775 T15743 T15742 compound Fat,Mass
R4776 T15744 T15745 npadvmod Tissue,Specific
R4777 T15745 T15747 amod Specific,Regulation
R4778 T15746 T15745 punct -,Specific
R4779 T15747 T15738 dobj Regulation,Illustrate
R4780 T15748 T15747 prep of,Regulation
R4781 T15749 T15750 det the,Trait
R4782 T15750 T15748 pobj Trait,of
R4783 T15752 T15753 prep In,fitted
R4784 T15754 T15755 det an,effort
R4785 T15755 T15752 pobj effort,In
R4786 T15756 T15757 aux to,identify
R4787 T15757 T15755 acl identify,effort
R4788 T15758 T15757 dobj genes,identify
R4789 T15759 T15758 acl associated,genes
R4790 T15760 T15759 prep with,associated
R4791 T15761 T15762 det the,trait
R4792 T15762 T15760 pobj trait,with
R4793 T15763 T15764 compound fat,mass
R4794 T15764 T15762 compound mass,trait
R4795 T15765 T15758 punct ", ",genes
R4796 T15766 T15758 cc but,genes
R4797 T15767 T15768 neg not,necessarily
R4798 T15768 T15769 advmod necessarily,genes
R4799 T15769 T15758 conj genes,genes
R4800 T15770 T15769 compound candidate,genes
R4801 T15771 T15769 acl underlying,genes
R4802 T15772 T15773 det the,cQTLs
R4803 T15773 T15771 dobj cQTLs,underlying
R4804 T15774 T15773 compound trait,cQTLs
R4805 T15775 T15753 punct ", ",fitted
R4806 T15776 T15753 nsubj we,fitted
R4807 T15777 T15778 amod linear,models
R4808 T15778 T15753 dobj models,fitted
R4809 T15779 T15780 aux to,assess
R4810 T15780 T15753 advcl assess,fitted
R4811 T15781 T15782 det the,degree
R4812 T15782 T15780 dobj degree,assess
R4813 T15783 T15782 prep of,degree
R4814 T15784 T15783 pobj association,of
R4815 T15785 T15784 prep between,association
R4816 T15786 T15785 pobj transcripts,between
R4817 T15787 T15786 cc and,transcripts
R4818 T15788 T15789 amod gonadal,mass
R4819 T15789 T15786 conj mass,transcripts
R4820 T15790 T15789 compound fat,mass
R4821 T15791 T15753 punct .,fitted
R4822 T15793 T15794 prep As,modeled
R4823 T15795 T15793 prep with,As
R4824 T15796 T15795 pobj QTLs,with
R4825 T15797 T15794 punct ", ",modeled
R4826 T15798 T15799 npadvmod sex,specific
R4827 T15799 T15801 amod specific,correlations
R4828 T15800 T15799 punct -,specific
R4829 T15801 T15794 nsubjpass correlations,modeled
R4830 T15802 T15794 auxpass were,modeled
R4831 T15803 T15794 punct .,modeled
R4832 T15805 T15806 prep At,found
R4833 T15807 T15808 det an,FDR
R4834 T15808 T15805 pobj FDR,At
R4835 T15809 T15808 prep of,FDR
R4836 T15810 T15811 nummod 1,%
R4837 T15811 T15809 pobj %,of
R4838 T15812 T15806 punct ", ",found
R4839 T15813 T15814 nummod "4,613",genes
R4840 T15814 T15806 nsubjpass genes,found
R4841 T15815 T15806 auxpass were,found
R4842 T15816 T15817 aux to,correlated
R4843 T15817 T15806 xcomp correlated,found
R4844 T15818 T15817 auxpass be,correlated
R4845 T15819 T15817 advmod significantly,correlated
R4846 T15820 T15817 prep with,correlated
R4847 T15821 T15822 amod gonadal,mass
R4848 T15822 T15820 pobj mass,with
R4849 T15823 T15822 compound fat,mass
R4850 T15824 T15806 punct ", ",found
R4851 T15825 T15826 prep of,showed
R4852 T15826 T15806 ccomp showed,found
R4853 T15827 T15825 pobj which,of
R4854 T15828 T15826 nsubj "4,254",showed
R4855 T15829 T15830 punct (,%
R4856 T15830 T15828 parataxis %,"4,254"
R4857 T15831 T15830 nummod 98,%
R4858 T15832 T15830 punct ),%
R4859 T15833 T15834 npadvmod sex,biased
R4860 T15834 T15836 amod biased,correlation
R4861 T15835 T15834 punct -,biased
R4862 T15836 T15826 dobj correlation,showed
R4863 T15837 T15806 punct .,found
R4864 T15839 T15840 mark As,indicated
R4865 T15840 T15841 advcl indicated,correlated
R4866 T15842 T15840 prep in,indicated
R4867 T15843 T15844 nmod Tables,4
R4868 T15844 T15842 pobj 4,in
R4869 T15845 T15844 cc and,4
R4870 T15846 T15844 conj 5,4
R4871 T15847 T15841 punct ", ",correlated
R4872 T15848 T15849 amod several,genes
R4873 T15849 T15841 nsubjpass genes,correlated
R4874 T15850 T15849 prep with,genes
R4875 T15851 T15852 amod detectable,eQTLs
R4876 T15852 T15850 pobj eQTLs,with
R4877 T15853 T15852 compound cis,eQTLs
R4878 T15854 T15852 punct -,eQTLs
R4879 T15855 T15841 auxpass are,correlated
R4880 T15856 T15841 advmod also,correlated
R4881 T15857 T15841 advmod significantly,correlated
R4882 T15858 T15841 prep with,correlated
R4883 T15859 T15860 det the,trait
R4884 T15860 T15858 pobj trait,with
R4885 T15861 T15841 cc and,correlated
R4886 T15862 T15863 auxpass are,prioritized
R4887 T15863 T15841 conj prioritized,correlated
R4888 T15864 T15865 advmod even,further
R4889 T15865 T15863 advmod further,prioritized
R4890 T15866 T15863 prep as,prioritized
R4891 T15867 T15868 compound candidate,genes
R4892 T15868 T15866 pobj genes,as
R4893 T15869 T15841 punct .,correlated
R4894 T15871 T15872 advmod Thus,far
R4895 T15872 T15873 advmod far,are
R4896 T15874 T15873 punct ", ",are
R4897 T15875 T15873 nsubj studies,are
R4898 T15876 T15877 dep that,examined
R4899 T15877 T15875 relcl examined,studies
R4900 T15878 T15877 aux have,examined
R4901 T15879 T15880 det the,genetics
R4902 T15880 T15877 dobj genetics,examined
R4903 T15881 T15880 punct “,genetics
R4904 T15882 T15880 prep of,genetics
R4905 T15883 T15884 compound gene,expression
R4906 T15884 T15882 pobj expression,of
R4907 T15885 T15873 punct ”,are
R4908 T15886 T15873 prep in,are
R4909 T15887 T15888 amod good,agreement
R4910 T15888 T15886 pobj agreement,in
R4911 T15889 T15888 prep regarding,agreement
R4912 T15890 T15891 det the,power
R4913 T15891 T15889 pobj power,regarding
R4914 T15892 T15891 amod increased,power
R4915 T15893 T15894 aux to,detect
R4916 T15894 T15891 acl detect,power
R4917 T15895 T15896 compound cis,eQTLs
R4918 T15896 T15894 dobj eQTLs,detect
R4919 T15897 T15896 punct -,eQTLs
R4920 T15898 T15894 advcl relative,detect
R4921 T15899 T15898 prep to,relative
R4922 T15900 T15899 pobj trans,to
R4923 T15901 T15902 punct [,31
R4924 T15902 T15873 parataxis 31,are
R4925 T15903 T15902 nummod 5,31
R4926 T15904 T15902 punct ",",31
R4927 T15905 T15902 nummod 9,31
R4928 T15906 T15902 punct ",",31
R4929 T15907 T15902 nummod 15,31
R4930 T15908 T15902 punct ",",31
R4931 T15909 T15902 nummod 16,31
R4932 T15910 T15902 punct ",",31
R4933 T15911 T15902 punct ],31
R4934 T15912 T15873 punct .,are
R4935 T15914 T15915 nsubj It,is
R4936 T15916 T15915 acomp unclear,is
R4937 T15917 T15915 prep at,is
R4938 T15918 T15919 det this,time
R4939 T15919 T15917 pobj time,at
R4940 T15920 T15915 punct ", ",is
R4941 T15921 T15915 advmod however,is
R4942 T15922 T15915 punct ", ",is
R4943 T15923 T15924 dep what,is
R4944 T15924 T15915 ccomp is,is
R4945 T15925 T15923 advmod exactly,what
R4946 T15926 T15927 det the,significance
R4947 T15927 T15924 attr significance,is
R4948 T15928 T15927 prep of,significance
R4949 T15929 T15930 compound trans,eQTLs
R4950 T15930 T15928 pobj eQTLs,of
R4951 T15931 T15930 punct -,eQTLs
R4952 T15932 T15927 cc and,significance
R4953 T15933 T15934 det the,nature
R4954 T15934 T15927 conj nature,significance
R4955 T15935 T15934 prep of,nature
R4956 T15936 T15937 det the,polymorphisms
R4957 T15937 T15935 pobj polymorphisms,of
R4958 T15938 T15937 amod underlying,polymorphisms
R4959 T15939 T15937 acl associated,polymorphisms
R4960 T15940 T15939 prep with,associated
R4961 T15941 T15940 pobj them,with
R4962 T15942 T15915 punct .,is
R4963 T15944 T15945 advmod Furthermore,represent
R4964 T15946 T15945 punct ", ",represent
R4965 T15947 T15948 det the,hotspots
R4966 T15948 T15945 nsubj hotspots,represent
R4967 T15949 T15948 compound eQTL,hotspots
R4968 T15950 T15948 acl reported,hotspots
R4969 T15951 T15950 prep in,reported
R4970 T15952 T15953 advmod this,previous
R4971 T15953 T15955 amod previous,studies
R4972 T15954 T15953 cc and,previous
R4973 T15955 T15951 pobj studies,in
R4974 T15956 T15957 punct [,10
R4975 T15957 T15948 parataxis 10,hotspots
R4976 T15958 T15957 nummod 5,10
R4977 T15959 T15957 punct ",",10
R4978 T15960 T15957 nummod 9,10
R4979 T15961 T15957 punct ",",10
R4980 T15962 T15957 punct ],10
R4981 T15963 T15945 advmod largely,represent
R4982 T15964 T15965 compound trans,eQTLs
R4983 T15965 T15945 dobj eQTLs,represent
R4984 T15966 T15965 punct -,eQTLs
R4985 T15967 T15945 punct .,represent
R4986 T15969 T15970 det This,localization
R4987 T15970 T15971 nsubj localization,suggests
R4988 T15972 T15973 det some,significance
R4989 T15973 T15971 dobj significance,suggests
R4990 T15974 T15973 amod functional,significance
R4991 T15975 T15973 prep to,significance
R4992 T15976 T15977 det these,regions
R4993 T15977 T15975 pobj regions,to
R4994 T15978 T15971 punct .,suggests
R4995 T15980 T15981 prep Of,generate
R4996 T15982 T15983 det the,genes
R4997 T15983 T15980 pobj genes,Of
R4998 T15984 T15983 nummod "4,613",genes
R4999 T15985 T15983 acl correlated,genes
R5000 T15986 T15985 prep with,correlated
R5001 T15987 T15988 amod gonadal,mass
R5002 T15988 T15986 pobj mass,with
R5003 T15989 T15988 compound fat,mass
R5004 T15990 T15981 punct ", ",generate
R5005 T15991 T15981 nsubj "1,130",generate
R5006 T15992 T15993 nummod "1,478",eQTLs
R5007 T15993 T15981 dobj eQTLs,generate
R5008 T15994 T15993 amod significant,eQTLs
R5009 T15995 T15993 punct ", ",eQTLs
R5010 T15996 T15997 prep of,are
R5011 T15997 T15993 relcl are,eQTLs
R5012 T15998 T15996 pobj which,of
R5013 T15999 T15997 nsubj "1,023",are
R5014 T16000 T16001 punct (,%
R5015 T16001 T15999 parataxis %,"1,023"
R5016 T16002 T16001 nummod 69,%
R5017 T16003 T16001 punct ),%
R5018 T16004 T16005 npadvmod trans,acting
R5019 T16005 T15997 acomp acting,are
R5020 T16006 T16005 punct -,acting
R5021 T16007 T15981 punct .,generate
R5022 T16009 T16010 det These,eQTLs
R5023 T16010 T16011 nsubjpass eQTLs,enriched
R5024 T16012 T16011 auxpass are,enriched
R5025 T16013 T16011 advmod significantly,enriched
R5026 T16014 T16011 prep at,enriched
R5027 T16015 T16016 nummod one,locus
R5028 T16016 T16014 pobj locus,at
R5029 T16017 T16018 punct (,Chromosome
R5030 T16018 T16016 parataxis Chromosome,locus
R5031 T16019 T16018 nummod 19,Chromosome
R5032 T16020 T16018 punct ),Chromosome
R5033 T16021 T16011 punct .,enriched
R5034 T16023 T16024 advmod Interestingly,was
R5035 T16025 T16024 punct ", ",was
R5036 T16026 T16027 det this,hotspot
R5037 T16027 T16024 nsubj hotspot,was
R5038 T16028 T16024 acomp coincident,was
R5039 T16029 T16028 prep with,coincident
R5040 T16030 T16031 det a,cQTL
R5041 T16031 T16029 pobj cQTL,with
R5042 T16032 T16031 acl associated,cQTL
R5043 T16033 T16032 prep with,associated
R5044 T16034 T16035 compound fat,mass
R5045 T16035 T16033 pobj mass,with
R5046 T16036 T16031 acl reported,cQTL
R5047 T16037 T16036 prep in,reported
R5048 T16038 T16039 det this,study
R5049 T16039 T16037 pobj study,in
R5050 T16040 T16024 punct .,was
R5051 T16042 T16043 mark Since,represent
R5052 T16043 T16046 advcl represent,supports
R5053 T16044 T16045 det these,transcripts
R5054 T16045 T16043 nsubj transcripts,represent
R5055 T16047 T16043 dobj those,represent
R5056 T16048 T16049 advmod significantly,correlated
R5057 T16049 T16047 acl correlated,those
R5058 T16050 T16049 prep with,correlated
R5059 T16051 T16052 amod gonadal,mass
R5060 T16052 T16050 pobj mass,with
R5061 T16053 T16052 compound fat,mass
R5062 T16054 T16046 punct ", ",supports
R5063 T16055 T16056 det the,localization
R5064 T16056 T16046 nsubj localization,supports
R5065 T16057 T16056 prep of,localization
R5066 T16058 T16059 poss their,eQTLs
R5067 T16059 T16057 pobj eQTLs,of
R5068 T16060 T16056 prep to,localization
R5069 T16061 T16062 det these,regions
R5070 T16062 T16060 pobj regions,to
R5071 T16063 T16046 advmod strongly,supports
R5072 T16064 T16065 det the,notion
R5073 T16065 T16046 dobj notion,supports
R5074 T16066 T16067 mark that,represent
R5075 T16067 T16065 acl represent,notion
R5076 T16068 T16069 det the,genes
R5077 T16069 T16067 nsubj genes,represent
R5078 T16070 T16069 prep with,genes
R5079 T16071 T16072 compound trans,eQTLs
R5080 T16072 T16070 pobj eQTLs,with
R5081 T16073 T16072 punct -,eQTLs
R5082 T16074 T16075 amod downstream,targets
R5083 T16075 T16067 dobj targets,represent
R5084 T16076 T16075 prep of,targets
R5085 T16077 T16078 nmod candidate,genes
R5086 T16078 T16076 pobj genes,of
R5087 T16079 T16078 amod regulatory,genes
R5088 T16080 T16078 acl located,genes
R5089 T16081 T16080 prep at,located
R5090 T16082 T16083 det the,position
R5091 T16083 T16081 pobj position,at
R5092 T16084 T16083 prep of,position
R5093 T16085 T16086 amod significant,linkage
R5094 T16086 T16084 pobj linkage,of
R5095 T16087 T16046 punct .,supports
R5096 T16089 T16090 nsubj This,means
R5097 T16091 T16092 mark that,be
R5098 T16092 T16090 ccomp be,means
R5099 T16093 T16094 det the,genes
R5100 T16094 T16092 nsubj genes,be
R5101 T16095 T16092 aux may,be
R5102 T16096 T16092 acomp causal,be
R5103 T16097 T16096 cc but,causal
R5104 T16098 T16096 conj downstream,causal
R5105 T16099 T16098 prep of,downstream
R5106 T16100 T16101 det the,gene
R5107 T16101 T16099 pobj gene,of
R5108 T16102 T16101 amod responsible,gene
R5109 T16103 T16102 prep for,responsible
R5110 T16104 T16105 det the,cQTLs
R5111 T16105 T16103 pobj cQTLs,for
R5112 T16106 T16092 punct ", ",be
R5113 T16107 T16092 cc or,be
R5114 T16108 T16109 nsubj they,reacting
R5115 T16109 T16092 conj reacting,be
R5116 T16110 T16109 aux may,reacting
R5117 T16111 T16109 aux be,reacting
R5118 T16112 T16109 prep to,reacting
R5119 T16113 T16114 det the,mass
R5120 T16114 T16112 pobj mass,to
R5121 T16115 T16114 amod increased,mass
R5122 T16116 T16114 amod gonadal,mass
R5123 T16117 T16114 compound fat,mass
R5124 T16118 T16114 cc and,mass
R5125 T16119 T16120 amod associated,changes
R5126 T16120 T16114 conj changes,mass
R5127 T16121 T16120 amod metabolic,changes
R5128 T16122 T16090 punct .,means
R5129 T16124 T16125 det These,data
R5130 T16125 T16126 nsubj data,suggest
R5131 T16127 T16126 advmod also,suggest
R5132 T16128 T16129 mark that,is
R5133 T16129 T16126 ccomp is,suggest
R5134 T16130 T16129 csubj identifying,is
R5135 T16131 T16132 amod such,loci
R5136 T16132 T16130 dobj loci,identifying
R5137 T16133 T16134 dep that,show
R5138 T16134 T16132 relcl show,loci
R5139 T16135 T16134 dobj overrepresentation,show
R5140 T16136 T16135 prep of,overrepresentation
R5141 T16137 T16138 advmod highly,correlated
R5142 T16138 T16139 amod correlated,genes
R5143 T16139 T16136 pobj genes,of
R5144 T16140 T16141 det a,means
R5145 T16141 T16129 attr means,is
R5146 T16142 T16143 aux to,identify
R5147 T16143 T16141 advcl identify,means
R5148 T16144 T16145 dep which,controlled
R5149 T16145 T16143 ccomp controlled,identify
R5150 T16146 T16144 prep of,which
R5151 T16147 T16148 det the,cQTLs
R5152 T16148 T16146 pobj cQTLs,of
R5153 T16149 T16148 compound trait,cQTLs
R5154 T16150 T16145 auxpass are,controlled
R5155 T16151 T16152 advmod more,likely
R5156 T16152 T16145 advmod likely,controlled
R5157 T16153 T16145 agent by,controlled
R5158 T16154 T16155 det the,tissue
R5159 T16155 T16153 pobj tissue,by
R5160 T16156 T16155 acl arrayed,tissue
R5161 T16157 T16126 punct .,suggest
R5162 T16159 T16160 mark As,expected
R5163 T16160 T16161 advcl expected,was
R5164 T16162 T16161 punct ", ",was
R5165 T16163 T16164 det the,locus
R5166 T16164 T16161 nsubj locus,was
R5167 T16165 T16164 nmod Chromosome,locus
R5168 T16166 T16165 nummod 19,Chromosome
R5169 T16167 T16161 acomp enriched,was
R5170 T16168 T16167 prep for,enriched
R5171 T16169 T16170 compound trans,eQTLs
R5172 T16170 T16168 pobj eQTLs,for
R5173 T16171 T16170 punct -,eQTLs
R5174 T16172 T16161 prep with,was
R5175 T16173 T16174 advmod substantially,greater
R5176 T16174 T16175 amod greater,effects
R5177 T16175 T16172 pobj effects,with
R5178 T16176 T16175 prep in,effects
R5179 T16177 T16176 pobj females,in
R5180 T16178 T16161 punct .,was
R5181 T16180 T16181 amod Functional,analysis
R5182 T16181 T16184 nsubj analysis,prove
R5183 T16182 T16180 cc and,Functional
R5184 T16183 T16180 conj promoter,Functional
R5185 T16185 T16181 prep of,analysis
R5186 T16186 T16185 pobj genes,of
R5187 T16187 T16181 prep with,analysis
R5188 T16188 T16189 det a,eQTL
R5189 T16189 T16187 pobj eQTL,with
R5190 T16190 T16189 amod common,eQTL
R5191 T16191 T16189 compound trans,eQTL
R5192 T16192 T16189 punct -,eQTL
R5193 T16193 T16184 aux may,prove
R5194 T16194 T16184 oprd enlightening,prove
R5195 T16195 T16184 punct .,prove
R5196 T16197 T16198 advmod Furthermore,improved
R5197 T16199 T16198 punct ", ",improved
R5198 T16200 T16201 compound gene,expression
R5199 T16201 T16202 compound expression,construction
R5200 T16202 T16198 nsubjpass construction,improved
R5201 T16203 T16202 compound network,construction
R5202 T16204 T16202 cc and,construction
R5203 T16205 T16202 conj analysis,construction
R5204 T16206 T16198 aux may,improved
R5205 T16207 T16198 auxpass be,improved
R5206 T16208 T16198 agent by,improved
R5207 T16209 T16210 det the,incorporation
R5208 T16210 T16208 pobj incorporation,by
R5209 T16211 T16210 prep of,incorporation
R5210 T16212 T16213 advmod experimentally,demonstrated
R5211 T16213 T16214 amod demonstrated,regulation
R5212 T16214 T16211 pobj regulation,of
R5213 T16215 T16216 nmod cis,trans
R5214 T16216 T16214 compound trans,regulation
R5215 T16217 T16216 nmod versus,trans
R5216 T16218 T16198 punct .,improved