Id |
Subject |
Object |
Predicate |
Lexical cue |
T1372 |
0-5 |
NN |
denotes |
Aging |
T1374 |
6-9 |
VBZ |
denotes |
has |
T1375 |
10-14 |
RB |
denotes |
long |
T1376 |
15-19 |
VBN |
denotes |
been |
T1373 |
20-30 |
VBN |
denotes |
associated |
T1377 |
31-35 |
IN |
denotes |
with |
T1378 |
36-38 |
DT |
denotes |
an |
T1379 |
39-47 |
NN |
denotes |
increase |
T1380 |
48-50 |
IN |
denotes |
in |
T1381 |
51-57 |
NN |
denotes |
marrow |
T1382 |
58-61 |
NN |
denotes |
fat |
T1383 |
61-63 |
, |
denotes |
, |
T1384 |
63-68 |
WRB |
denotes |
where |
T1386 |
69-72 |
DT |
denotes |
the |
T1387 |
73-83 |
NN |
denotes |
generation |
T1388 |
84-86 |
IN |
denotes |
of |
T1389 |
87-97 |
NNS |
denotes |
adipocytes |
T1390 |
98-100 |
VBZ |
denotes |
is |
T1385 |
101-108 |
VBN |
denotes |
favored |
T1391 |
109-113 |
IN |
denotes |
over |
T1392 |
114-125 |
NNS |
denotes |
osteoblasts |
T1393 |
126-127 |
-LRB- |
denotes |
[ |
T1394 |
127-129 |
CD |
denotes |
23 |
T1395 |
129-130 |
-RRB- |
denotes |
] |
T1396 |
130-131 |
. |
denotes |
. |
T1397 |
131-351 |
sentence |
denotes |
Osteoblasts and adipocytes are derived from a common mesenchymal precursor cell present in bone marrow, and the factors that control this age-induced switch toward adipogenic differentiation is not well understood [24]. |
T1398 |
132-143 |
NNS |
denotes |
Osteoblasts |
T1400 |
144-147 |
CC |
denotes |
and |
T1401 |
148-158 |
NNS |
denotes |
adipocytes |
T1402 |
159-162 |
VBP |
denotes |
are |
T1399 |
163-170 |
VBN |
denotes |
derived |
T1403 |
171-175 |
IN |
denotes |
from |
T1404 |
176-177 |
DT |
denotes |
a |
T1406 |
178-184 |
JJ |
denotes |
common |
T1407 |
185-196 |
JJ |
denotes |
mesenchymal |
T1408 |
197-206 |
NN |
denotes |
precursor |
T1405 |
207-211 |
NN |
denotes |
cell |
T1409 |
212-219 |
JJ |
denotes |
present |
T1410 |
220-222 |
IN |
denotes |
in |
T1411 |
223-227 |
NN |
denotes |
bone |
T1412 |
228-234 |
NN |
denotes |
marrow |
T1413 |
234-236 |
, |
denotes |
, |
T1414 |
236-239 |
CC |
denotes |
and |
T1415 |
240-243 |
DT |
denotes |
the |
T1416 |
244-251 |
NNS |
denotes |
factors |
T1418 |
252-256 |
WDT |
denotes |
that |
T1419 |
257-264 |
VBP |
denotes |
control |
T1420 |
265-269 |
DT |
denotes |
this |
T1422 |
270-273 |
NN |
denotes |
age |
T1424 |
273-274 |
HYPH |
denotes |
- |
T1423 |
274-281 |
VBN |
denotes |
induced |
T1421 |
282-288 |
NN |
denotes |
switch |
T1425 |
289-295 |
IN |
denotes |
toward |
T1426 |
296-306 |
JJ |
denotes |
adipogenic |
T1427 |
307-322 |
NN |
denotes |
differentiation |
T1428 |
323-325 |
VBZ |
denotes |
is |
T1429 |
326-329 |
RB |
denotes |
not |
T1430 |
330-334 |
RB |
denotes |
well |
T1417 |
335-345 |
VBN |
denotes |
understood |
T1431 |
346-347 |
-LRB- |
denotes |
[ |
T1432 |
347-349 |
CD |
denotes |
24 |
T1433 |
349-350 |
-RRB- |
denotes |
] |
T1434 |
350-351 |
. |
denotes |
. |
T1435 |
351-632 |
sentence |
denotes |
While several transcriptional regulatory proteins have been associated with cell fate determination of bone marrow mesenchymal cells, including peroxisome proliferator–activated receptor γ (PPARγ) and KLF5 [25–30], the role of RNA binding proteins in this process remains unknown. |
T1436 |
352-357 |
IN |
denotes |
While |
T1438 |
358-365 |
JJ |
denotes |
several |
T1440 |
366-381 |
JJ |
denotes |
transcriptional |
T1441 |
382-392 |
JJ |
denotes |
regulatory |
T1439 |
393-401 |
NN |
denotes |
proteins |
T1442 |
402-406 |
VBP |
denotes |
have |
T1443 |
407-411 |
VBN |
denotes |
been |
T1437 |
412-422 |
VBN |
denotes |
associated |
T1445 |
423-427 |
IN |
denotes |
with |
T1446 |
428-432 |
NN |
denotes |
cell |
T1448 |
433-437 |
NN |
denotes |
fate |
T1447 |
438-451 |
NN |
denotes |
determination |
T1449 |
452-454 |
IN |
denotes |
of |
T1450 |
455-459 |
NN |
denotes |
bone |
T1451 |
460-466 |
NN |
denotes |
marrow |
T1453 |
467-478 |
JJ |
denotes |
mesenchymal |
T1452 |
479-484 |
NNS |
denotes |
cells |
T1454 |
484-486 |
, |
denotes |
, |
T1455 |
486-495 |
VBG |
denotes |
including |
T1456 |
496-506 |
NN |
denotes |
peroxisome |
T1458 |
507-519 |
NN |
denotes |
proliferator |
T1460 |
519-520 |
HYPH |
denotes |
– |
T1459 |
520-529 |
VBN |
denotes |
activated |
T1457 |
530-538 |
NN |
denotes |
receptor |
T1461 |
539-540 |
SYM |
denotes |
γ |
T1462 |
541-542 |
-LRB- |
denotes |
( |
T1463 |
542-547 |
NN |
denotes |
PPARγ |
T1464 |
547-548 |
-RRB- |
denotes |
) |
T1465 |
549-552 |
CC |
denotes |
and |
T1466 |
553-557 |
NN |
denotes |
KLF5 |
T1467 |
558-559 |
-LRB- |
denotes |
[ |
T1468 |
559-561 |
CD |
denotes |
25 |
T1469 |
561-562 |
SYM |
denotes |
– |
T1470 |
562-564 |
CD |
denotes |
30 |
T1471 |
564-565 |
-RRB- |
denotes |
] |
T1472 |
565-567 |
, |
denotes |
, |
T1473 |
567-570 |
DT |
denotes |
the |
T1474 |
571-575 |
NN |
denotes |
role |
T1475 |
576-578 |
IN |
denotes |
of |
T1476 |
579-582 |
NN |
denotes |
RNA |
T1478 |
583-590 |
NN |
denotes |
binding |
T1477 |
591-599 |
NN |
denotes |
proteins |
T1479 |
600-602 |
IN |
denotes |
in |
T1480 |
603-607 |
DT |
denotes |
this |
T1481 |
608-615 |
NN |
denotes |
process |
T1444 |
616-623 |
VBZ |
denotes |
remains |
T1482 |
624-631 |
JJ |
denotes |
unknown |
T1483 |
631-632 |
. |
denotes |
. |
T1484 |
632-718 |
sentence |
denotes |
RNA binding proteins of the KH type are known regulators of cellular differentiation. |
T1485 |
633-636 |
NN |
denotes |
RNA |
T1487 |
637-644 |
NN |
denotes |
binding |
T1486 |
645-653 |
NN |
denotes |
proteins |
T1489 |
654-656 |
IN |
denotes |
of |
T1490 |
657-660 |
DT |
denotes |
the |
T1492 |
661-663 |
NN |
denotes |
KH |
T1491 |
664-668 |
NN |
denotes |
type |
T1488 |
669-672 |
VBP |
denotes |
are |
T1493 |
673-678 |
JJ |
denotes |
known |
T1494 |
679-689 |
NNS |
denotes |
regulators |
T1495 |
690-692 |
IN |
denotes |
of |
T1496 |
693-701 |
JJ |
denotes |
cellular |
T1497 |
702-717 |
NN |
denotes |
differentiation |
T1498 |
717-718 |
. |
denotes |
. |
T1499 |
718-908 |
sentence |
denotes |
For example, expression defects in the KH domain proteins NOVA and FMRP are known to cause paraneoplastic neurologic disorders [31] and the fragile X syndrome, respectively, in humans [32]. |
T1500 |
719-722 |
IN |
denotes |
For |
T1502 |
723-730 |
NN |
denotes |
example |
T1503 |
730-732 |
, |
denotes |
, |
T1504 |
732-742 |
NN |
denotes |
expression |
T1505 |
743-750 |
NNS |
denotes |
defects |
T1506 |
751-753 |
IN |
denotes |
in |
T1507 |
754-757 |
DT |
denotes |
the |
T1509 |
758-760 |
NN |
denotes |
KH |
T1510 |
761-767 |
NN |
denotes |
domain |
T1508 |
768-776 |
NN |
denotes |
proteins |
T1511 |
777-781 |
NN |
denotes |
NOVA |
T1512 |
782-785 |
CC |
denotes |
and |
T1513 |
786-790 |
NN |
denotes |
FMRP |
T1514 |
791-794 |
VBP |
denotes |
are |
T1501 |
795-800 |
VBN |
denotes |
known |
T1515 |
801-803 |
TO |
denotes |
to |
T1516 |
804-809 |
VB |
denotes |
cause |
T1517 |
810-824 |
JJ |
denotes |
paraneoplastic |
T1519 |
825-835 |
JJ |
denotes |
neurologic |
T1518 |
836-845 |
NNS |
denotes |
disorders |
T1520 |
846-847 |
-LRB- |
denotes |
[ |
T1521 |
847-849 |
CD |
denotes |
31 |
T1522 |
849-850 |
-RRB- |
denotes |
] |
T1523 |
851-854 |
CC |
denotes |
and |
T1524 |
855-858 |
DT |
denotes |
the |
T1526 |
859-866 |
JJ |
denotes |
fragile |
T1527 |
867-868 |
NN |
denotes |
X |
T1525 |
869-877 |
NN |
denotes |
syndrome |
T1528 |
877-879 |
, |
denotes |
, |
T1529 |
879-891 |
RB |
denotes |
respectively |
T1530 |
891-893 |
, |
denotes |
, |
T1531 |
893-895 |
IN |
denotes |
in |
T1532 |
896-902 |
NNS |
denotes |
humans |
T1533 |
903-904 |
-LRB- |
denotes |
[ |
T1534 |
904-906 |
CD |
denotes |
32 |
T1535 |
906-907 |
-RRB- |
denotes |
] |
T1536 |
907-908 |
. |
denotes |
. |
T1537 |
908-1043 |
sentence |
denotes |
The phenotype of the quaking viable mice suggests a role for the QUAKING RNA binding protein in oligodendrocytes and myelination [33]. |
T1538 |
909-912 |
DT |
denotes |
The |
T1539 |
913-922 |
NN |
denotes |
phenotype |
T1541 |
923-925 |
IN |
denotes |
of |
T1542 |
926-929 |
DT |
denotes |
the |
T1544 |
930-937 |
NN |
denotes |
quaking |
T1545 |
938-944 |
JJ |
denotes |
viable |
T1543 |
945-949 |
NNS |
denotes |
mice |
T1540 |
950-958 |
VBZ |
denotes |
suggests |
T1546 |
959-960 |
DT |
denotes |
a |
T1547 |
961-965 |
NN |
denotes |
role |
T1548 |
966-969 |
IN |
denotes |
for |
T1549 |
970-973 |
DT |
denotes |
the |
T1551 |
974-981 |
NN |
denotes |
QUAKING |
T1552 |
982-985 |
NN |
denotes |
RNA |
T1553 |
986-993 |
NN |
denotes |
binding |
T1550 |
994-1001 |
NN |
denotes |
protein |
T1554 |
1002-1004 |
IN |
denotes |
in |
T1555 |
1005-1021 |
NNS |
denotes |
oligodendrocytes |
T1556 |
1022-1025 |
CC |
denotes |
and |
T1557 |
1026-1037 |
NN |
denotes |
myelination |
T1558 |
1038-1039 |
-LRB- |
denotes |
[ |
T1559 |
1039-1041 |
CD |
denotes |
33 |
T1560 |
1041-1042 |
-RRB- |
denotes |
] |
T1561 |
1042-1043 |
. |
denotes |
. |
T1562 |
1043-1242 |
sentence |
denotes |
Indeed, the ectopic expression of the QKI-6/7 isoforms in vivo led to the formation of glial cells rather than neurons from neural progenitor, demonstrating its role in cell fate determination [34]. |
T1563 |
1044-1050 |
RB |
denotes |
Indeed |
T1565 |
1050-1052 |
, |
denotes |
, |
T1566 |
1052-1055 |
DT |
denotes |
the |
T1568 |
1056-1063 |
JJ |
denotes |
ectopic |
T1567 |
1064-1074 |
NN |
denotes |
expression |
T1569 |
1075-1077 |
IN |
denotes |
of |
T1570 |
1078-1081 |
DT |
denotes |
the |
T1572 |
1082-1085 |
NN |
denotes |
QKI |
T1574 |
1085-1086 |
HYPH |
denotes |
- |
T1575 |
1086-1087 |
CD |
denotes |
6 |
T1576 |
1087-1088 |
HYPH |
denotes |
/ |
T1573 |
1088-1089 |
CD |
denotes |
7 |
T1571 |
1090-1098 |
NNS |
denotes |
isoforms |
T1577 |
1099-1101 |
FW |
denotes |
in |
T1578 |
1102-1106 |
FW |
denotes |
vivo |
T1564 |
1107-1110 |
VBD |
denotes |
led |
T1579 |
1111-1113 |
IN |
denotes |
to |
T1580 |
1114-1117 |
DT |
denotes |
the |
T1581 |
1118-1127 |
NN |
denotes |
formation |
T1582 |
1128-1130 |
IN |
denotes |
of |
T1583 |
1131-1136 |
JJ |
denotes |
glial |
T1584 |
1137-1142 |
NNS |
denotes |
cells |
T1585 |
1143-1149 |
RB |
denotes |
rather |
T1586 |
1150-1154 |
IN |
denotes |
than |
T1587 |
1155-1162 |
NNS |
denotes |
neurons |
T1588 |
1163-1167 |
IN |
denotes |
from |
T1589 |
1168-1174 |
JJ |
denotes |
neural |
T1590 |
1175-1185 |
NN |
denotes |
progenitor |
T1591 |
1185-1187 |
, |
denotes |
, |
T1592 |
1187-1200 |
VBG |
denotes |
demonstrating |
T1593 |
1201-1204 |
PRP$ |
denotes |
its |
T1594 |
1205-1209 |
NN |
denotes |
role |
T1595 |
1210-1212 |
IN |
denotes |
in |
T1596 |
1213-1217 |
NN |
denotes |
cell |
T1598 |
1218-1222 |
NN |
denotes |
fate |
T1597 |
1223-1236 |
NN |
denotes |
determination |
T1599 |
1237-1238 |
-LRB- |
denotes |
[ |
T1600 |
1238-1240 |
CD |
denotes |
34 |
T1601 |
1240-1241 |
-RRB- |
denotes |
] |
T1602 |
1241-1242 |
. |
denotes |
. |
T1603 |
1242-1479 |
sentence |
denotes |
The loss of GLD-1 protein in Caenorhabditis elegans prevents the appearance of stem cells [35], and the absence of the KH domain protein HOW in Drosophila prevents muscle differentiation and results in flies with held-out-wings [36,37]. |
T1604 |
1243-1246 |
DT |
denotes |
The |
T1605 |
1247-1251 |
NN |
denotes |
loss |
T1607 |
1252-1254 |
IN |
denotes |
of |
T1608 |
1255-1258 |
NN |
denotes |
GLD |
T1610 |
1258-1259 |
HYPH |
denotes |
- |
T1611 |
1259-1260 |
CD |
denotes |
1 |
T1609 |
1261-1268 |
NN |
denotes |
protein |
T1612 |
1269-1271 |
IN |
denotes |
in |
T1613 |
1272-1286 |
NNP |
denotes |
Caenorhabditis |
T1614 |
1287-1294 |
NNP |
denotes |
elegans |
T1606 |
1295-1303 |
VBZ |
denotes |
prevents |
T1615 |
1304-1307 |
DT |
denotes |
the |
T1616 |
1308-1318 |
NN |
denotes |
appearance |
T1617 |
1319-1321 |
IN |
denotes |
of |
T1618 |
1322-1326 |
NN |
denotes |
stem |
T1619 |
1327-1332 |
NNS |
denotes |
cells |
T1620 |
1333-1334 |
-LRB- |
denotes |
[ |
T1621 |
1334-1336 |
CD |
denotes |
35 |
T1622 |
1336-1337 |
-RRB- |
denotes |
] |
T1623 |
1337-1339 |
, |
denotes |
, |
T1624 |
1339-1342 |
CC |
denotes |
and |
T1625 |
1343-1346 |
DT |
denotes |
the |
T1626 |
1347-1354 |
NN |
denotes |
absence |
T1628 |
1355-1357 |
IN |
denotes |
of |
T1629 |
1358-1361 |
DT |
denotes |
the |
T1631 |
1362-1364 |
NN |
denotes |
KH |
T1632 |
1365-1371 |
NN |
denotes |
domain |
T1630 |
1372-1379 |
NN |
denotes |
protein |
T1633 |
1380-1383 |
NN |
denotes |
HOW |
T1634 |
1384-1386 |
IN |
denotes |
in |
T1635 |
1387-1397 |
NNP |
denotes |
Drosophila |
T1627 |
1398-1406 |
VBZ |
denotes |
prevents |
T1636 |
1407-1413 |
NN |
denotes |
muscle |
T1637 |
1414-1429 |
NN |
denotes |
differentiation |
T1638 |
1430-1433 |
CC |
denotes |
and |
T1639 |
1434-1441 |
VBZ |
denotes |
results |
T1640 |
1442-1444 |
IN |
denotes |
in |
T1641 |
1445-1450 |
NNS |
denotes |
flies |
T1642 |
1451-1455 |
IN |
denotes |
with |
T1643 |
1456-1460 |
VBN |
denotes |
held |
T1645 |
1460-1461 |
HYPH |
denotes |
- |
T1646 |
1461-1464 |
RP |
denotes |
out |
T1647 |
1464-1465 |
HYPH |
denotes |
- |
T1644 |
1465-1470 |
NNS |
denotes |
wings |
T1648 |
1471-1472 |
-LRB- |
denotes |
[ |
T1650 |
1472-1474 |
CD |
denotes |
36 |
T1651 |
1474-1475 |
, |
denotes |
, |
T1649 |
1475-1477 |
CD |
denotes |
37 |
T1652 |
1477-1478 |
-RRB- |
denotes |
] |
T1653 |
1478-1479 |
. |
denotes |
. |
T1654 |
1479-1662 |
sentence |
denotes |
The Src substrate associated in mitosis of 68 kDa (Sam68) is also a member of the family of KH domain RNA binding proteins [38]; however, its physiologic role has remained undefined. |
T1655 |
1480-1483 |
DT |
denotes |
The |
T1657 |
1484-1487 |
NN |
denotes |
Src |
T1656 |
1488-1497 |
NN |
denotes |
substrate |
T1659 |
1498-1508 |
VBN |
denotes |
associated |
T1660 |
1509-1511 |
IN |
denotes |
in |
T1661 |
1512-1519 |
NN |
denotes |
mitosis |
T1662 |
1520-1522 |
IN |
denotes |
of |
T1663 |
1523-1525 |
CD |
denotes |
68 |
T1664 |
1526-1529 |
NN |
denotes |
kDa |
T1665 |
1530-1531 |
-LRB- |
denotes |
( |
T1666 |
1531-1536 |
NN |
denotes |
Sam68 |
T1667 |
1536-1537 |
-RRB- |
denotes |
) |
T1658 |
1538-1540 |
VBZ |
denotes |
is |
T1669 |
1541-1545 |
RB |
denotes |
also |
T1670 |
1546-1547 |
DT |
denotes |
a |
T1671 |
1548-1554 |
NN |
denotes |
member |
T1672 |
1555-1557 |
IN |
denotes |
of |
T1673 |
1558-1561 |
DT |
denotes |
the |
T1674 |
1562-1568 |
NN |
denotes |
family |
T1675 |
1569-1571 |
IN |
denotes |
of |
T1676 |
1572-1574 |
NN |
denotes |
KH |
T1678 |
1575-1581 |
NN |
denotes |
domain |
T1679 |
1582-1585 |
NN |
denotes |
RNA |
T1680 |
1586-1593 |
NN |
denotes |
binding |
T1677 |
1594-1602 |
NN |
denotes |
proteins |
T1681 |
1603-1604 |
-LRB- |
denotes |
[ |
T1682 |
1604-1606 |
CD |
denotes |
38 |
T1683 |
1606-1607 |
-RRB- |
denotes |
] |
T1684 |
1607-1608 |
: |
denotes |
; |
T1685 |
1609-1616 |
RB |
denotes |
however |
T1686 |
1616-1618 |
, |
denotes |
, |
T1687 |
1618-1621 |
PRP$ |
denotes |
its |
T1689 |
1622-1633 |
JJ |
denotes |
physiologic |
T1688 |
1634-1638 |
NN |
denotes |
role |
T1690 |
1639-1642 |
VBZ |
denotes |
has |
T1668 |
1643-1651 |
VBN |
denotes |
remained |
T1691 |
1652-1661 |
JJ |
denotes |
undefined |
T1692 |
1661-1662 |
. |
denotes |
. |
R639 |
T1372 |
T1373 |
nsubjpass |
Aging,associated |
R640 |
T1374 |
T1373 |
aux |
has,associated |
R641 |
T1375 |
T1373 |
advmod |
long,associated |
R642 |
T1376 |
T1373 |
auxpass |
been,associated |
R643 |
T1377 |
T1373 |
prep |
with,associated |
R644 |
T1378 |
T1379 |
det |
an,increase |
R645 |
T1379 |
T1377 |
pobj |
increase,with |
R646 |
T1380 |
T1379 |
prep |
in,increase |
R647 |
T1381 |
T1382 |
compound |
marrow,fat |
R648 |
T1382 |
T1380 |
pobj |
fat,in |
R649 |
T1383 |
T1382 |
punct |
", ",fat |
R650 |
T1384 |
T1385 |
advmod |
where,favored |
R651 |
T1385 |
T1382 |
relcl |
favored,fat |
R652 |
T1386 |
T1387 |
det |
the,generation |
R653 |
T1387 |
T1385 |
nsubjpass |
generation,favored |
R654 |
T1388 |
T1387 |
prep |
of,generation |
R655 |
T1389 |
T1388 |
pobj |
adipocytes,of |
R656 |
T1390 |
T1385 |
auxpass |
is,favored |
R657 |
T1391 |
T1385 |
prep |
over,favored |
R658 |
T1392 |
T1391 |
pobj |
osteoblasts,over |
R659 |
T1393 |
T1394 |
punct |
[,23 |
R660 |
T1394 |
T1373 |
parataxis |
23,associated |
R661 |
T1395 |
T1394 |
punct |
],23 |
R662 |
T1396 |
T1373 |
punct |
.,associated |
R663 |
T1398 |
T1399 |
nsubjpass |
Osteoblasts,derived |
R664 |
T1400 |
T1398 |
cc |
and,Osteoblasts |
R665 |
T1401 |
T1398 |
conj |
adipocytes,Osteoblasts |
R666 |
T1402 |
T1399 |
auxpass |
are,derived |
R667 |
T1403 |
T1399 |
prep |
from,derived |
R668 |
T1404 |
T1405 |
det |
a,cell |
R669 |
T1405 |
T1403 |
pobj |
cell,from |
R670 |
T1406 |
T1405 |
amod |
common,cell |
R671 |
T1407 |
T1405 |
amod |
mesenchymal,cell |
R672 |
T1408 |
T1405 |
compound |
precursor,cell |
R673 |
T1409 |
T1405 |
relcl |
present,cell |
R674 |
T1410 |
T1409 |
prep |
in,present |
R675 |
T1411 |
T1412 |
compound |
bone,marrow |
R676 |
T1412 |
T1410 |
pobj |
marrow,in |
R677 |
T1413 |
T1399 |
punct |
", ",derived |
R678 |
T1414 |
T1399 |
cc |
and,derived |
R679 |
T1415 |
T1416 |
det |
the,factors |
R680 |
T1416 |
T1417 |
nsubjpass |
factors,understood |
R681 |
T1417 |
T1399 |
conj |
understood,derived |
R682 |
T1418 |
T1419 |
dep |
that,control |
R683 |
T1419 |
T1416 |
relcl |
control,factors |
R684 |
T1420 |
T1421 |
det |
this,switch |
R685 |
T1421 |
T1419 |
dobj |
switch,control |
R686 |
T1422 |
T1423 |
npadvmod |
age,induced |
R687 |
T1423 |
T1421 |
amod |
induced,switch |
R688 |
T1424 |
T1423 |
punct |
-,induced |
R689 |
T1425 |
T1421 |
prep |
toward,switch |
R690 |
T1426 |
T1427 |
amod |
adipogenic,differentiation |
R691 |
T1427 |
T1425 |
pobj |
differentiation,toward |
R692 |
T1428 |
T1417 |
auxpass |
is,understood |
R693 |
T1429 |
T1417 |
neg |
not,understood |
R694 |
T1430 |
T1417 |
advmod |
well,understood |
R695 |
T1431 |
T1432 |
punct |
[,24 |
R696 |
T1432 |
T1417 |
parataxis |
24,understood |
R697 |
T1433 |
T1432 |
punct |
],24 |
R698 |
T1434 |
T1417 |
punct |
.,understood |
R699 |
T1436 |
T1437 |
mark |
While,associated |
R700 |
T1437 |
T1444 |
advcl |
associated,remains |
R701 |
T1438 |
T1439 |
amod |
several,proteins |
R702 |
T1439 |
T1437 |
nsubjpass |
proteins,associated |
R703 |
T1440 |
T1439 |
amod |
transcriptional,proteins |
R704 |
T1441 |
T1439 |
amod |
regulatory,proteins |
R705 |
T1442 |
T1437 |
aux |
have,associated |
R706 |
T1443 |
T1437 |
auxpass |
been,associated |
R707 |
T1445 |
T1437 |
prep |
with,associated |
R708 |
T1446 |
T1447 |
compound |
cell,determination |
R709 |
T1447 |
T1445 |
pobj |
determination,with |
R710 |
T1448 |
T1447 |
compound |
fate,determination |
R711 |
T1449 |
T1447 |
prep |
of,determination |
R712 |
T1450 |
T1451 |
nmod |
bone,marrow |
R713 |
T1451 |
T1452 |
nmod |
marrow,cells |
R714 |
T1452 |
T1449 |
pobj |
cells,of |
R715 |
T1453 |
T1452 |
amod |
mesenchymal,cells |
R716 |
T1454 |
T1452 |
punct |
", ",cells |
R717 |
T1455 |
T1452 |
prep |
including,cells |
R718 |
T1456 |
T1457 |
nmod |
peroxisome,receptor |
R719 |
T1457 |
T1455 |
pobj |
receptor,including |
R720 |
T1458 |
T1459 |
npadvmod |
proliferator,activated |
R721 |
T1459 |
T1457 |
amod |
activated,receptor |
R722 |
T1460 |
T1459 |
punct |
–,activated |
R723 |
T1461 |
T1457 |
punct |
γ,receptor |
R724 |
T1462 |
T1457 |
punct |
(,receptor |
R725 |
T1463 |
T1457 |
appos |
PPARγ,receptor |
R726 |
T1464 |
T1457 |
punct |
),receptor |
R727 |
T1465 |
T1457 |
cc |
and,receptor |
R728 |
T1466 |
T1457 |
conj |
KLF5,receptor |
R729 |
T1467 |
T1468 |
punct |
[,25 |
R730 |
T1468 |
T1437 |
parataxis |
25,associated |
R731 |
T1469 |
T1470 |
punct |
–,30 |
R732 |
T1470 |
T1468 |
prep |
30,25 |
R733 |
T1471 |
T1468 |
punct |
],25 |
R734 |
T1472 |
T1444 |
punct |
", ",remains |
R735 |
T1473 |
T1474 |
det |
the,role |
R736 |
T1474 |
T1444 |
nsubj |
role,remains |
R737 |
T1475 |
T1474 |
prep |
of,role |
R738 |
T1476 |
T1477 |
compound |
RNA,proteins |
R739 |
T1477 |
T1475 |
pobj |
proteins,of |
R740 |
T1478 |
T1477 |
compound |
binding,proteins |
R741 |
T1479 |
T1474 |
prep |
in,role |
R742 |
T1480 |
T1481 |
det |
this,process |
R743 |
T1481 |
T1479 |
pobj |
process,in |
R744 |
T1482 |
T1444 |
acomp |
unknown,remains |
R745 |
T1483 |
T1444 |
punct |
.,remains |
R746 |
T1485 |
T1486 |
compound |
RNA,proteins |
R747 |
T1486 |
T1488 |
nsubj |
proteins,are |
R748 |
T1487 |
T1486 |
compound |
binding,proteins |
R749 |
T1489 |
T1486 |
prep |
of,proteins |
R750 |
T1490 |
T1491 |
det |
the,type |
R751 |
T1491 |
T1489 |
pobj |
type,of |
R752 |
T1492 |
T1491 |
compound |
KH,type |
R753 |
T1493 |
T1494 |
amod |
known,regulators |
R754 |
T1494 |
T1488 |
attr |
regulators,are |
R755 |
T1495 |
T1494 |
prep |
of,regulators |
R756 |
T1496 |
T1497 |
amod |
cellular,differentiation |
R757 |
T1497 |
T1495 |
pobj |
differentiation,of |
R758 |
T1498 |
T1488 |
punct |
.,are |
R759 |
T1500 |
T1501 |
prep |
For,known |
R760 |
T1502 |
T1500 |
pobj |
example,For |
R761 |
T1503 |
T1501 |
punct |
", ",known |
R762 |
T1504 |
T1505 |
compound |
expression,defects |
R763 |
T1505 |
T1501 |
nsubjpass |
defects,known |
R764 |
T1506 |
T1505 |
prep |
in,defects |
R765 |
T1507 |
T1508 |
det |
the,proteins |
R766 |
T1508 |
T1506 |
pobj |
proteins,in |
R767 |
T1509 |
T1510 |
compound |
KH,domain |
R768 |
T1510 |
T1508 |
compound |
domain,proteins |
R769 |
T1511 |
T1508 |
appos |
NOVA,proteins |
R770 |
T1512 |
T1511 |
cc |
and,NOVA |
R771 |
T1513 |
T1511 |
conj |
FMRP,NOVA |
R772 |
T1514 |
T1501 |
auxpass |
are,known |
R773 |
T1515 |
T1516 |
aux |
to,cause |
R774 |
T1516 |
T1501 |
xcomp |
cause,known |
R775 |
T1517 |
T1518 |
amod |
paraneoplastic,disorders |
R776 |
T1518 |
T1516 |
dobj |
disorders,cause |
R777 |
T1519 |
T1518 |
amod |
neurologic,disorders |
R778 |
T1520 |
T1521 |
punct |
[,31 |
R779 |
T1521 |
T1518 |
parataxis |
31,disorders |
R780 |
T1522 |
T1521 |
punct |
],31 |
R781 |
T1523 |
T1518 |
cc |
and,disorders |
R782 |
T1524 |
T1525 |
det |
the,syndrome |
R783 |
T1525 |
T1518 |
conj |
syndrome,disorders |
R784 |
T1526 |
T1527 |
amod |
fragile,X |
R785 |
T1527 |
T1525 |
compound |
X,syndrome |
R786 |
T1528 |
T1516 |
punct |
", ",cause |
R787 |
T1529 |
T1516 |
advmod |
respectively,cause |
R788 |
T1530 |
T1516 |
punct |
", ",cause |
R789 |
T1531 |
T1516 |
prep |
in,cause |
R790 |
T1532 |
T1531 |
pobj |
humans,in |
R791 |
T1533 |
T1534 |
punct |
[,32 |
R792 |
T1534 |
T1516 |
parataxis |
32,cause |
R793 |
T1535 |
T1534 |
punct |
],32 |
R794 |
T1536 |
T1501 |
punct |
.,known |
R795 |
T1538 |
T1539 |
det |
The,phenotype |
R796 |
T1539 |
T1540 |
nsubj |
phenotype,suggests |
R797 |
T1541 |
T1539 |
prep |
of,phenotype |
R798 |
T1542 |
T1543 |
det |
the,mice |
R799 |
T1543 |
T1541 |
pobj |
mice,of |
R800 |
T1544 |
T1543 |
nmod |
quaking,mice |
R801 |
T1545 |
T1543 |
amod |
viable,mice |
R802 |
T1546 |
T1547 |
det |
a,role |
R803 |
T1547 |
T1540 |
dobj |
role,suggests |
R804 |
T1548 |
T1547 |
prep |
for,role |
R805 |
T1549 |
T1550 |
det |
the,protein |
R806 |
T1550 |
T1548 |
pobj |
protein,for |
R807 |
T1551 |
T1550 |
compound |
QUAKING,protein |
R808 |
T1552 |
T1553 |
compound |
RNA,binding |
R809 |
T1553 |
T1550 |
compound |
binding,protein |
R810 |
T1554 |
T1547 |
prep |
in,role |
R811 |
T1555 |
T1554 |
pobj |
oligodendrocytes,in |
R812 |
T1556 |
T1555 |
cc |
and,oligodendrocytes |
R813 |
T1557 |
T1555 |
conj |
myelination,oligodendrocytes |
R814 |
T1558 |
T1559 |
punct |
[,33 |
R815 |
T1559 |
T1540 |
parataxis |
33,suggests |
R816 |
T1560 |
T1559 |
punct |
],33 |
R817 |
T1561 |
T1540 |
punct |
.,suggests |
R818 |
T1563 |
T1564 |
advmod |
Indeed,led |
R819 |
T1565 |
T1564 |
punct |
", ",led |
R820 |
T1566 |
T1567 |
det |
the,expression |
R821 |
T1567 |
T1564 |
nsubj |
expression,led |
R822 |
T1568 |
T1567 |
amod |
ectopic,expression |
R823 |
T1569 |
T1567 |
prep |
of,expression |
R824 |
T1570 |
T1571 |
det |
the,isoforms |
R825 |
T1571 |
T1569 |
pobj |
isoforms,of |
R826 |
T1572 |
T1573 |
nmod |
QKI,7 |
R827 |
T1573 |
T1571 |
nummod |
7,isoforms |
R828 |
T1574 |
T1573 |
punct |
-,7 |
R829 |
T1575 |
T1573 |
nummod |
6,7 |
R830 |
T1576 |
T1573 |
punct |
/,7 |
R831 |
T1577 |
T1578 |
advmod |
in,vivo |
R832 |
T1578 |
T1564 |
advmod |
vivo,led |
R833 |
T1579 |
T1564 |
prep |
to,led |
R834 |
T1580 |
T1581 |
det |
the,formation |
R835 |
T1581 |
T1579 |
pobj |
formation,to |
R836 |
T1582 |
T1581 |
prep |
of,formation |
R837 |
T1583 |
T1584 |
amod |
glial,cells |
R838 |
T1584 |
T1582 |
pobj |
cells,of |
R839 |
T1585 |
T1586 |
advmod |
rather,than |
R840 |
T1586 |
T1584 |
cc |
than,cells |
R841 |
T1587 |
T1584 |
conj |
neurons,cells |
R842 |
T1588 |
T1581 |
prep |
from,formation |
R843 |
T1589 |
T1590 |
amod |
neural,progenitor |
R844 |
T1590 |
T1588 |
pobj |
progenitor,from |
R845 |
T1591 |
T1564 |
punct |
", ",led |
R846 |
T1592 |
T1564 |
advcl |
demonstrating,led |
R847 |
T1593 |
T1594 |
poss |
its,role |
R848 |
T1594 |
T1592 |
dobj |
role,demonstrating |
R849 |
T1595 |
T1594 |
prep |
in,role |
R850 |
T1596 |
T1597 |
compound |
cell,determination |
R851 |
T1597 |
T1595 |
pobj |
determination,in |
R852 |
T1598 |
T1597 |
compound |
fate,determination |
R853 |
T1599 |
T1600 |
punct |
[,34 |
R854 |
T1600 |
T1564 |
parataxis |
34,led |
R855 |
T1601 |
T1600 |
punct |
],34 |
R856 |
T1602 |
T1564 |
punct |
.,led |
R857 |
T1604 |
T1605 |
det |
The,loss |
R858 |
T1605 |
T1606 |
nsubj |
loss,prevents |
R859 |
T1607 |
T1605 |
prep |
of,loss |
R860 |
T1608 |
T1609 |
nmod |
GLD,protein |
R861 |
T1609 |
T1607 |
pobj |
protein,of |
R862 |
T1610 |
T1608 |
punct |
-,GLD |
R863 |
T1611 |
T1608 |
nummod |
1,GLD |
R864 |
T1612 |
T1605 |
prep |
in,loss |
R865 |
T1613 |
T1614 |
compound |
Caenorhabditis,elegans |
R866 |
T1614 |
T1612 |
pobj |
elegans,in |
R867 |
T1615 |
T1616 |
det |
the,appearance |
R868 |
T1616 |
T1606 |
dobj |
appearance,prevents |
R869 |
T1617 |
T1616 |
prep |
of,appearance |
R870 |
T1618 |
T1619 |
compound |
stem,cells |
R871 |
T1619 |
T1617 |
pobj |
cells,of |
R872 |
T1620 |
T1621 |
punct |
[,35 |
R873 |
T1621 |
T1606 |
parataxis |
35,prevents |
R874 |
T1622 |
T1621 |
punct |
],35 |
R875 |
T1623 |
T1606 |
punct |
", ",prevents |
R876 |
T1624 |
T1606 |
cc |
and,prevents |
R877 |
T1625 |
T1626 |
det |
the,absence |
R878 |
T1626 |
T1627 |
nsubj |
absence,prevents |
R879 |
T1627 |
T1606 |
conj |
prevents,prevents |
R880 |
T1628 |
T1626 |
prep |
of,absence |
R881 |
T1629 |
T1630 |
det |
the,protein |
R882 |
T1630 |
T1628 |
pobj |
protein,of |
R883 |
T1631 |
T1630 |
compound |
KH,protein |
R884 |
T1632 |
T1630 |
compound |
domain,protein |
R885 |
T1633 |
T1630 |
appos |
HOW,protein |
R886 |
T1634 |
T1626 |
prep |
in,absence |
R887 |
T1635 |
T1634 |
pobj |
Drosophila,in |
R888 |
T1636 |
T1637 |
compound |
muscle,differentiation |
R889 |
T1637 |
T1627 |
dobj |
differentiation,prevents |
R890 |
T1638 |
T1627 |
cc |
and,prevents |
R891 |
T1639 |
T1627 |
conj |
results,prevents |
R892 |
T1640 |
T1639 |
prep |
in,results |
R893 |
T1641 |
T1640 |
pobj |
flies,in |
R894 |
T1642 |
T1641 |
prep |
with,flies |
R895 |
T1643 |
T1644 |
amod |
held,wings |
R896 |
T1644 |
T1642 |
pobj |
wings,with |
R897 |
T1645 |
T1643 |
punct |
-,held |
R898 |
T1646 |
T1643 |
prt |
out,held |
R899 |
T1647 |
T1644 |
punct |
-,wings |
R900 |
T1648 |
T1649 |
punct |
[,37 |
R901 |
T1649 |
T1639 |
parataxis |
37,results |
R902 |
T1650 |
T1649 |
nummod |
36,37 |
R903 |
T1651 |
T1649 |
punct |
",",37 |
R904 |
T1652 |
T1649 |
punct |
],37 |
R905 |
T1653 |
T1627 |
punct |
.,prevents |
R906 |
T1655 |
T1656 |
det |
The,substrate |
R907 |
T1656 |
T1658 |
nsubj |
substrate,is |
R908 |
T1657 |
T1656 |
compound |
Src,substrate |
R909 |
T1658 |
T1668 |
ccomp |
is,remained |
R910 |
T1659 |
T1656 |
acl |
associated,substrate |
R911 |
T1660 |
T1659 |
prep |
in,associated |
R912 |
T1661 |
T1660 |
pobj |
mitosis,in |
R913 |
T1662 |
T1661 |
prep |
of,mitosis |
R914 |
T1663 |
T1664 |
nummod |
68,kDa |
R915 |
T1664 |
T1662 |
pobj |
kDa,of |
R916 |
T1665 |
T1666 |
punct |
(,Sam68 |
R917 |
T1666 |
T1659 |
parataxis |
Sam68,associated |
R918 |
T1667 |
T1666 |
punct |
),Sam68 |
R919 |
T1669 |
T1658 |
advmod |
also,is |
R920 |
T1670 |
T1671 |
det |
a,member |
R921 |
T1671 |
T1658 |
attr |
member,is |
R922 |
T1672 |
T1671 |
prep |
of,member |
R923 |
T1673 |
T1674 |
det |
the,family |
R924 |
T1674 |
T1672 |
pobj |
family,of |
R925 |
T1675 |
T1674 |
prep |
of,family |
R926 |
T1676 |
T1677 |
compound |
KH,proteins |
R927 |
T1677 |
T1675 |
pobj |
proteins,of |
R928 |
T1678 |
T1677 |
compound |
domain,proteins |
R929 |
T1679 |
T1680 |
compound |
RNA,binding |
R930 |
T1680 |
T1677 |
compound |
binding,proteins |
R931 |
T1681 |
T1682 |
punct |
[,38 |
R932 |
T1682 |
T1658 |
parataxis |
38,is |
R933 |
T1683 |
T1682 |
punct |
],38 |
R934 |
T1684 |
T1668 |
punct |
;,remained |
R935 |
T1685 |
T1668 |
advmod |
however,remained |
R936 |
T1686 |
T1668 |
punct |
", ",remained |
R937 |
T1687 |
T1688 |
poss |
its,role |
R938 |
T1688 |
T1668 |
nsubj |
role,remained |
R939 |
T1689 |
T1688 |
amod |
physiologic,role |
R940 |
T1690 |
T1668 |
aux |
has,remained |
R941 |
T1691 |
T1668 |
acomp |
undefined,remained |
R942 |
T1692 |
T1668 |
punct |
.,remained |