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PMC:1315279 / 34290-35868 JSONTXT 5 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T7995 0-3 DT denotes The
T7997 4-12 JJ denotes skeletal
T7996 13-24 NN denotes phenotyping
T7999 25-27 IN denotes of
T8000 28-35 NNS denotes cohorts
T8001 36-38 IN denotes of
T8002 39-44 NN denotes Sam68
T8004 44-45 SYM denotes +
T8005 45-46 HYPH denotes /
T8006 46-47 SYM denotes +
T8007 48-51 CC denotes and
T8008 52-57 NN denotes Sam68
T8009 57-58 SYM denotes −
T8010 58-59 HYPH denotes /
T8011 59-60 SYM denotes −
T8003 61-65 NNS denotes mice
T7998 66-72 VBD denotes showed
T8012 73-77 IN denotes that
T8014 78-82 NN denotes bone
T8015 83-87 NN denotes mass
T8016 88-91 VBD denotes was
T8013 92-101 VBN denotes preserved
T8017 102-104 IN denotes in
T8018 105-109 JJ denotes aged
T8020 110-115 NN denotes Sam68
T8021 115-116 SYM denotes −
T8022 116-117 HYPH denotes /
T8023 117-118 SYM denotes −
T8019 119-123 NNS denotes mice
T8024 123-124 . denotes .
T8025 124-257 sentence denotes Traditional histology and histomorphometry suggested that the mechanism involved preservation of osteoblast and osteoclast activity.
T8026 125-136 JJ denotes Traditional
T8027 137-146 NN denotes histology
T8029 147-150 CC denotes and
T8030 151-167 NN denotes histomorphometry
T8028 168-177 VBD denotes suggested
T8031 178-182 IN denotes that
T8033 183-186 DT denotes the
T8034 187-196 NN denotes mechanism
T8032 197-205 VBD denotes involved
T8035 206-218 NN denotes preservation
T8036 219-221 IN denotes of
T8037 222-232 NN denotes osteoblast
T8039 233-236 CC denotes and
T8040 237-247 NN denotes osteoclast
T8038 248-256 NN denotes activity
T8041 256-257 DT denotes .
T8042 257-415 sentence denotes The documented role of the Sam68 regulatory protein, Src, in osteopetrosis led us to investigate the morphology and activity of Sam68−/− osteoclasts ex vivo.
T8043 258-261 DT denotes The
T8045 262-272 VBN denotes documented
T8044 273-277 NN denotes role
T8047 278-280 IN denotes of
T8048 281-284 DT denotes the
T8050 285-290 NN denotes Sam68
T8051 291-301 JJ denotes regulatory
T8049 302-309 NN denotes protein
T8052 309-311 , denotes ,
T8053 311-314 NN denotes Src
T8054 314-316 , denotes ,
T8055 316-318 IN denotes in
T8056 319-332 NN denotes osteopetrosis
T8046 333-336 VBD denotes led
T8057 337-339 PRP denotes us
T8058 340-342 TO denotes to
T8059 343-354 VB denotes investigate
T8060 355-358 DT denotes the
T8061 359-369 NN denotes morphology
T8062 370-373 CC denotes and
T8063 374-382 NN denotes activity
T8064 383-385 IN denotes of
T8065 386-391 NN denotes Sam68
T8067 391-392 SYM denotes −
T8068 392-393 HYPH denotes /
T8069 393-394 SYM denotes −
T8066 395-406 NNS denotes osteoclasts
T8070 407-409 FW denotes ex
T8071 410-414 FW denotes vivo
T8072 414-415 . denotes .
T8073 415-633 sentence denotes The Src tyrosine kinase was shown to play a role in bone remodeling when Src−/− mice died at 6 months of age with an osteopetrotic phenotype [48] and the defect was attributed to defective osteoclast function [55−59].
T8074 416-419 DT denotes The
T8076 420-423 NN denotes Src
T8077 424-432 NN denotes tyrosine
T8075 433-439 NN denotes kinase
T8079 440-443 VBD denotes was
T8078 444-449 VBN denotes shown
T8080 450-452 TO denotes to
T8081 453-457 VB denotes play
T8082 458-459 DT denotes a
T8083 460-464 NN denotes role
T8084 465-467 IN denotes in
T8085 468-472 NN denotes bone
T8086 473-483 NN denotes remodeling
T8087 484-488 WRB denotes when
T8089 489-492 NN denotes Src
T8091 492-493 SYM denotes −
T8092 493-494 HYPH denotes /
T8093 494-495 SYM denotes −
T8090 496-500 NNS denotes mice
T8088 501-505 VBD denotes died
T8094 506-508 IN denotes at
T8095 509-510 CD denotes 6
T8096 511-517 NNS denotes months
T8097 518-520 IN denotes of
T8098 521-524 NN denotes age
T8099 525-529 IN denotes with
T8100 530-532 DT denotes an
T8102 533-546 JJ denotes osteopetrotic
T8101 547-556 NN denotes phenotype
T8103 557-558 -LRB- denotes [
T8104 558-560 CD denotes 48
T8105 560-561 -RRB- denotes ]
T8106 562-565 CC denotes and
T8107 566-569 DT denotes the
T8108 570-576 NN denotes defect
T8110 577-580 VBD denotes was
T8109 581-591 VBN denotes attributed
T8111 592-594 IN denotes to
T8112 595-604 JJ denotes defective
T8114 605-615 NN denotes osteoclast
T8113 616-624 NN denotes function
T8115 625-626 -LRB- denotes [
T8116 626-628 CD denotes 55
T8117 628-629 SYM denotes −
T8118 629-631 CD denotes 59
T8119 631-632 -RRB- denotes ]
T8120 632-633 . denotes .
T8121 633-780 sentence denotes We therefore cultured mature osteoclasts harvested from Sam68+/+ and Sam68−/− mice ex vivo on dentin slices to quantify their resorptive capacity.
T8122 634-636 PRP denotes We
T8124 637-646 RB denotes therefore
T8123 647-655 VBD denotes cultured
T8125 656-662 JJ denotes mature
T8126 663-674 NNS denotes osteoclasts
T8127 675-684 VBN denotes harvested
T8128 685-689 IN denotes from
T8129 690-695 NN denotes Sam68
T8131 695-696 SYM denotes +
T8132 696-697 HYPH denotes /
T8133 697-698 SYM denotes +
T8134 699-702 CC denotes and
T8135 703-708 NN denotes Sam68
T8136 708-709 SYM denotes −
T8137 709-710 HYPH denotes /
T8138 710-711 SYM denotes −
T8130 712-716 NNS denotes mice
T8139 717-719 FW denotes ex
T8140 720-724 FW denotes vivo
T8141 725-727 IN denotes on
T8142 728-734 NN denotes dentin
T8143 735-741 NNS denotes slices
T8144 742-744 TO denotes to
T8145 745-753 VB denotes quantify
T8146 754-759 PRP$ denotes their
T8148 760-770 JJ denotes resorptive
T8147 771-779 NN denotes capacity
T8149 779-780 . denotes .
T8150 780-996 sentence denotes The fact that Sam68−/− osteoclasts looked and acted like Sam68+/+ osteoclasts ex vivo and in vivo made it unlikely that this was the primary source of the difference in bone metabolism in 12-month-old Sam68−/− mice.
T8151 781-784 DT denotes The
T8152 785-789 NN denotes fact
T8154 790-794 IN denotes that
T8156 795-800 NN denotes Sam68
T8158 800-801 SYM denotes −
T8159 801-802 HYPH denotes /
T8160 802-803 SYM denotes −
T8157 804-815 NNS denotes osteoclasts
T8155 816-822 VBD denotes looked
T8161 823-826 CC denotes and
T8162 827-832 VBD denotes acted
T8163 833-837 IN denotes like
T8164 838-843 NN denotes Sam68
T8166 843-844 SYM denotes +
T8167 844-845 HYPH denotes /
T8168 845-846 SYM denotes +
T8165 847-858 NNS denotes osteoclasts
T8169 859-861 FW denotes ex
T8170 862-866 FW denotes vivo
T8171 867-870 CC denotes and
T8172 871-873 FW denotes in
T8173 874-878 FW denotes vivo
T8153 879-883 VBD denotes made
T8174 884-886 PRP denotes it
T8175 887-895 JJ denotes unlikely
T8176 896-900 IN denotes that
T8178 901-905 DT denotes this
T8177 906-909 VBD denotes was
T8179 910-913 DT denotes the
T8181 914-921 JJ denotes primary
T8180 922-928 NN denotes source
T8182 929-931 IN denotes of
T8183 932-935 DT denotes the
T8184 936-946 NN denotes difference
T8185 947-949 IN denotes in
T8186 950-954 NN denotes bone
T8187 955-965 NN denotes metabolism
T8188 966-968 IN denotes in
T8189 969-971 CD denotes 12
T8191 971-972 HYPH denotes -
T8190 972-977 NN denotes month
T8193 977-978 HYPH denotes -
T8192 978-981 JJ denotes old
T8195 982-987 NN denotes Sam68
T8196 987-988 SYM denotes −
T8197 988-989 HYPH denotes /
T8198 989-990 SYM denotes −
T8194 991-995 NNS denotes mice
T8199 995-996 . denotes .
T8200 996-1160 sentence denotes The fact that the CTX levels were lower in young and old Sam68−/− mice suggested that there is reduced bone resorption compared with wild-type littermate controls.
T8201 997-1000 DT denotes The
T8202 1001-1005 NN denotes fact
T8204 1006-1010 IN denotes that
T8206 1011-1014 DT denotes the
T8208 1015-1018 NN denotes CTX
T8207 1019-1025 NNS denotes levels
T8205 1026-1030 VBD denotes were
T8209 1031-1036 JJR denotes lower
T8210 1037-1039 IN denotes in
T8211 1040-1045 JJ denotes young
T8213 1046-1049 CC denotes and
T8214 1050-1053 JJ denotes old
T8215 1054-1059 NN denotes Sam68
T8216 1059-1060 SYM denotes −
T8217 1060-1061 HYPH denotes /
T8218 1061-1062 SYM denotes −
T8212 1063-1067 NNS denotes mice
T8203 1068-1077 VBD denotes suggested
T8219 1078-1082 IN denotes that
T8221 1083-1088 EX denotes there
T8220 1089-1091 VBZ denotes is
T8222 1092-1099 VBN denotes reduced
T8224 1100-1104 NN denotes bone
T8223 1105-1115 NN denotes resorption
T8225 1116-1124 VBN denotes compared
T8226 1125-1129 IN denotes with
T8227 1130-1134 JJ denotes wild
T8229 1134-1135 HYPH denotes -
T8228 1135-1139 NN denotes type
T8231 1140-1150 NN denotes littermate
T8230 1151-1159 NNS denotes controls
T8232 1159-1160 . denotes .
T8233 1160-1280 sentence denotes However, this reduction in bone resorption occurred with normal osteoclast activity, as assessed by in vitro culturing.
T8234 1161-1168 RB denotes However
T8236 1168-1170 , denotes ,
T8237 1170-1174 DT denotes this
T8238 1175-1184 NN denotes reduction
T8239 1185-1187 IN denotes in
T8240 1188-1192 NN denotes bone
T8241 1193-1203 NN denotes resorption
T8235 1204-1212 VBD denotes occurred
T8242 1213-1217 IN denotes with
T8243 1218-1224 JJ denotes normal
T8245 1225-1235 NN denotes osteoclast
T8244 1236-1244 NN denotes activity
T8246 1244-1246 , denotes ,
T8247 1246-1248 IN denotes as
T8248 1249-1257 VBN denotes assessed
T8249 1258-1260 IN denotes by
T8250 1261-1263 FW denotes in
T8251 1264-1269 FW denotes vitro
T8252 1270-1279 NN denotes culturing
T8253 1279-1280 . denotes .
T8254 1280-1373 sentence denotes These observations are consistent with the Sam68−/− mice having a youth-like bone phenotype.
T8255 1281-1286 DT denotes These
T8256 1287-1299 NNS denotes observations
T8257 1300-1303 VBP denotes are
T8258 1304-1314 JJ denotes consistent
T8259 1315-1319 IN denotes with
T8260 1320-1323 DT denotes the
T8262 1324-1329 NN denotes Sam68
T8263 1329-1330 SYM denotes −
T8264 1330-1331 HYPH denotes /
T8265 1331-1332 SYM denotes −
T8261 1333-1337 NNS denotes mice
T8266 1338-1344 VBG denotes having
T8267 1345-1346 DT denotes a
T8269 1347-1352 NN denotes youth
T8271 1352-1353 HYPH denotes -
T8270 1353-1357 JJ denotes like
T8272 1358-1362 NN denotes bone
T8268 1363-1372 NN denotes phenotype
T8273 1372-1373 . denotes .
T8274 1373-1578 sentence denotes However, it is still possible, that a mild impairment in Sam68−/− mice osteoclast function may manifest itself later in life in overall accumulation of bone and this will require further detailed studies.
T8275 1374-1381 RB denotes However
T8277 1381-1383 , denotes ,
T8278 1383-1385 PRP denotes it
T8276 1386-1388 VBZ denotes is
T8279 1389-1394 RB denotes still
T8280 1395-1403 JJ denotes possible
T8281 1403-1405 , denotes ,
T8282 1405-1409 IN denotes that
T8284 1410-1411 DT denotes a
T8286 1412-1416 JJ denotes mild
T8285 1417-1427 NN denotes impairment
T8287 1428-1430 IN denotes in
T8288 1431-1436 NN denotes Sam68
T8290 1436-1437 SYM denotes −
T8291 1437-1438 HYPH denotes /
T8292 1438-1439 SYM denotes −
T8289 1440-1444 NNS denotes mice
T8294 1445-1455 NN denotes osteoclast
T8293 1456-1464 NN denotes function
T8295 1465-1468 MD denotes may
T8283 1469-1477 VB denotes manifest
T8296 1478-1484 PRP denotes itself
T8297 1485-1490 RB denotes later
T8298 1491-1493 IN denotes in
T8299 1494-1498 NN denotes life
T8300 1499-1501 IN denotes in
T8301 1502-1509 JJ denotes overall
T8302 1510-1522 NN denotes accumulation
T8303 1523-1525 IN denotes of
T8304 1526-1530 NN denotes bone
T8305 1531-1534 CC denotes and
T8306 1535-1539 DT denotes this
T8308 1540-1544 MD denotes will
T8307 1545-1552 VB denotes require
T8309 1553-1560 JJ denotes further
T8311 1561-1569 JJ denotes detailed
T8310 1570-1577 NNS denotes studies
T8312 1577-1578 . denotes .
R4720 T7995 T7996 det The,phenotyping
R4721 T7996 T7998 nsubj phenotyping,showed
R4722 T7997 T7996 amod skeletal,phenotyping
R4723 T7999 T7996 prep of,phenotyping
R4724 T8000 T7999 pobj cohorts,of
R4725 T8001 T8000 prep of,cohorts
R4726 T8002 T8003 nmod Sam68,mice
R4727 T8003 T8001 pobj mice,of
R4728 T8004 T8002 punct +,Sam68
R4729 T8005 T8002 punct /,Sam68
R4730 T8006 T8002 punct +,Sam68
R4731 T8007 T8002 cc and,Sam68
R4732 T8008 T8002 conj Sam68,Sam68
R4733 T8009 T8008 punct −,Sam68
R4734 T8010 T8008 punct /,Sam68
R4735 T8011 T8008 punct −,Sam68
R4736 T8012 T8013 mark that,preserved
R4737 T8013 T7998 ccomp preserved,showed
R4738 T8014 T8015 compound bone,mass
R4739 T8015 T8013 nsubjpass mass,preserved
R4740 T8016 T8013 auxpass was,preserved
R4741 T8017 T8013 prep in,preserved
R4742 T8018 T8019 amod aged,mice
R4743 T8019 T8017 pobj mice,in
R4744 T8020 T8019 nmod Sam68,mice
R4745 T8021 T8020 punct −,Sam68
R4746 T8022 T8020 punct /,Sam68
R4747 T8023 T8020 punct −,Sam68
R4748 T8024 T7998 punct .,showed
R4749 T8026 T8027 amod Traditional,histology
R4750 T8027 T8028 nsubj histology,suggested
R4751 T8029 T8027 cc and,histology
R4752 T8030 T8027 conj histomorphometry,histology
R4753 T8031 T8032 mark that,involved
R4754 T8032 T8028 ccomp involved,suggested
R4755 T8033 T8034 det the,mechanism
R4756 T8034 T8032 nsubj mechanism,involved
R4757 T8035 T8032 dobj preservation,involved
R4758 T8036 T8035 prep of,preservation
R4759 T8037 T8038 nmod osteoblast,activity
R4760 T8038 T8036 pobj activity,of
R4761 T8039 T8037 cc and,osteoblast
R4762 T8040 T8037 conj osteoclast,osteoblast
R4763 T8041 T8028 dep .,suggested
R4764 T8043 T8044 det The,role
R4765 T8044 T8046 nsubj role,led
R4766 T8045 T8044 amod documented,role
R4767 T8047 T8044 prep of,role
R4768 T8048 T8049 det the,protein
R4769 T8049 T8047 pobj protein,of
R4770 T8050 T8049 nmod Sam68,protein
R4771 T8051 T8049 amod regulatory,protein
R4772 T8052 T8049 punct ", ",protein
R4773 T8053 T8049 appos Src,protein
R4774 T8054 T8044 punct ", ",role
R4775 T8055 T8044 prep in,role
R4776 T8056 T8055 pobj osteopetrosis,in
R4777 T8057 T8046 dobj us,led
R4778 T8058 T8059 aux to,investigate
R4779 T8059 T8046 xcomp investigate,led
R4780 T8060 T8061 det the,morphology
R4781 T8061 T8059 dobj morphology,investigate
R4782 T8062 T8061 cc and,morphology
R4783 T8063 T8061 conj activity,morphology
R4784 T8064 T8061 prep of,morphology
R4785 T8065 T8066 nmod Sam68,osteoclasts
R4786 T8066 T8064 pobj osteoclasts,of
R4787 T8067 T8065 punct −,Sam68
R4788 T8068 T8065 punct /,Sam68
R4789 T8069 T8065 punct −,Sam68
R4790 T8070 T8071 advmod ex,vivo
R4791 T8071 T8059 advmod vivo,investigate
R4792 T8072 T8046 punct .,led
R4793 T8074 T8075 det The,kinase
R4794 T8075 T8078 nsubjpass kinase,shown
R4795 T8076 T8075 compound Src,kinase
R4796 T8077 T8075 compound tyrosine,kinase
R4797 T8079 T8078 auxpass was,shown
R4798 T8080 T8081 aux to,play
R4799 T8081 T8078 xcomp play,shown
R4800 T8082 T8083 det a,role
R4801 T8083 T8081 dobj role,play
R4802 T8084 T8081 prep in,play
R4803 T8085 T8086 compound bone,remodeling
R4804 T8086 T8084 pobj remodeling,in
R4805 T8087 T8088 advmod when,died
R4806 T8088 T8081 advcl died,play
R4807 T8089 T8090 nmod Src,mice
R4808 T8090 T8088 nsubj mice,died
R4809 T8091 T8089 punct −,Src
R4810 T8092 T8089 punct /,Src
R4811 T8093 T8089 punct −,Src
R4812 T8094 T8088 prep at,died
R4813 T8095 T8096 nummod 6,months
R4814 T8096 T8094 pobj months,at
R4815 T8097 T8096 prep of,months
R4816 T8098 T8097 pobj age,of
R4817 T8099 T8088 prep with,died
R4818 T8100 T8101 det an,phenotype
R4819 T8101 T8099 pobj phenotype,with
R4820 T8102 T8101 amod osteopetrotic,phenotype
R4821 T8103 T8104 punct [,48
R4822 T8104 T8088 parataxis 48,died
R4823 T8105 T8104 punct ],48
R4824 T8106 T8088 cc and,died
R4825 T8107 T8108 det the,defect
R4826 T8108 T8109 nsubjpass defect,attributed
R4827 T8109 T8088 conj attributed,died
R4828 T8110 T8109 auxpass was,attributed
R4829 T8111 T8109 prep to,attributed
R4830 T8112 T8113 amod defective,function
R4831 T8113 T8111 pobj function,to
R4832 T8114 T8113 compound osteoclast,function
R4833 T8115 T8116 punct [,55
R4834 T8116 T8109 parataxis 55,attributed
R4835 T8117 T8118 punct −,59
R4836 T8118 T8116 prep 59,55
R4837 T8119 T8116 punct ],55
R4838 T8120 T8078 punct .,shown
R4839 T8122 T8123 nsubj We,cultured
R4840 T8124 T8123 advmod therefore,cultured
R4841 T8125 T8126 amod mature,osteoclasts
R4842 T8126 T8123 dobj osteoclasts,cultured
R4843 T8127 T8126 acl harvested,osteoclasts
R4844 T8128 T8127 prep from,harvested
R4845 T8129 T8130 nmod Sam68,mice
R4846 T8130 T8128 pobj mice,from
R4847 T8131 T8129 punct +,Sam68
R4848 T8132 T8129 punct /,Sam68
R4849 T8133 T8129 punct +,Sam68
R4850 T8134 T8129 cc and,Sam68
R4851 T8135 T8129 conj Sam68,Sam68
R4852 T8136 T8135 punct −,Sam68
R4853 T8137 T8135 punct /,Sam68
R4854 T8138 T8135 punct −,Sam68
R4855 T8139 T8140 advmod ex,vivo
R4856 T8140 T8123 advmod vivo,cultured
R4857 T8141 T8123 prep on,cultured
R4858 T8142 T8143 compound dentin,slices
R4859 T8143 T8141 pobj slices,on
R4860 T8144 T8145 aux to,quantify
R4861 T8145 T8123 advcl quantify,cultured
R4862 T8146 T8147 poss their,capacity
R4863 T8147 T8145 dobj capacity,quantify
R4864 T8148 T8147 amod resorptive,capacity
R4865 T8149 T8123 punct .,cultured
R4866 T8151 T8152 det The,fact
R4867 T8152 T8153 nsubj fact,made
R4868 T8154 T8155 mark that,looked
R4869 T8155 T8152 acl looked,fact
R4870 T8156 T8157 nmod Sam68,osteoclasts
R4871 T8157 T8155 nsubj osteoclasts,looked
R4872 T8158 T8156 punct −,Sam68
R4873 T8159 T8156 punct /,Sam68
R4874 T8160 T8156 punct −,Sam68
R4875 T8161 T8155 cc and,looked
R4876 T8162 T8155 conj acted,looked
R4877 T8163 T8162 prep like,acted
R4878 T8164 T8165 nmod Sam68,osteoclasts
R4879 T8165 T8163 pobj osteoclasts,like
R4880 T8166 T8164 punct +,Sam68
R4881 T8167 T8164 punct /,Sam68
R4882 T8168 T8164 punct +,Sam68
R4883 T8169 T8170 advmod ex,vivo
R4884 T8170 T8162 advmod vivo,acted
R4885 T8171 T8170 cc and,vivo
R4886 T8172 T8173 advmod in,vivo
R4887 T8173 T8170 conj vivo,vivo
R4888 T8174 T8175 nsubj it,unlikely
R4889 T8175 T8153 ccomp unlikely,made
R4890 T8176 T8177 mark that,was
R4891 T8177 T8175 advcl was,unlikely
R4892 T8178 T8177 nsubj this,was
R4893 T8179 T8180 det the,source
R4894 T8180 T8177 attr source,was
R4895 T8181 T8180 amod primary,source
R4896 T8182 T8180 prep of,source
R4897 T8183 T8184 det the,difference
R4898 T8184 T8182 pobj difference,of
R4899 T8185 T8184 prep in,difference
R4900 T8186 T8187 compound bone,metabolism
R4901 T8187 T8185 pobj metabolism,in
R4902 T8188 T8177 prep in,was
R4903 T8189 T8190 nummod 12,month
R4904 T8190 T8192 npadvmod month,old
R4905 T8191 T8190 punct -,month
R4906 T8192 T8194 amod old,mice
R4907 T8193 T8192 punct -,old
R4908 T8194 T8188 pobj mice,in
R4909 T8195 T8194 nmod Sam68,mice
R4910 T8196 T8195 punct −,Sam68
R4911 T8197 T8195 punct /,Sam68
R4912 T8198 T8195 punct −,Sam68
R4913 T8199 T8153 punct .,made
R4914 T8201 T8202 det The,fact
R4915 T8202 T8203 nsubj fact,suggested
R4916 T8204 T8205 mark that,were
R4917 T8205 T8202 acl were,fact
R4918 T8206 T8207 det the,levels
R4919 T8207 T8205 nsubj levels,were
R4920 T8208 T8207 compound CTX,levels
R4921 T8209 T8205 acomp lower,were
R4922 T8210 T8205 prep in,were
R4923 T8211 T8212 amod young,mice
R4924 T8212 T8210 pobj mice,in
R4925 T8213 T8211 cc and,young
R4926 T8214 T8211 conj old,young
R4927 T8215 T8212 nmod Sam68,mice
R4928 T8216 T8215 punct −,Sam68
R4929 T8217 T8215 punct /,Sam68
R4930 T8218 T8215 punct −,Sam68
R4931 T8219 T8220 mark that,is
R4932 T8220 T8203 ccomp is,suggested
R4933 T8221 T8220 expl there,is
R4934 T8222 T8223 amod reduced,resorption
R4935 T8223 T8220 attr resorption,is
R4936 T8224 T8223 compound bone,resorption
R4937 T8225 T8223 prep compared,resorption
R4938 T8226 T8225 prep with,compared
R4939 T8227 T8228 amod wild,type
R4940 T8228 T8230 compound type,controls
R4941 T8229 T8228 punct -,type
R4942 T8230 T8226 pobj controls,with
R4943 T8231 T8230 compound littermate,controls
R4944 T8232 T8203 punct .,suggested
R4945 T8234 T8235 advmod However,occurred
R4946 T8236 T8235 punct ", ",occurred
R4947 T8237 T8238 det this,reduction
R4948 T8238 T8235 nsubj reduction,occurred
R4949 T8239 T8238 prep in,reduction
R4950 T8240 T8241 compound bone,resorption
R4951 T8241 T8239 pobj resorption,in
R4952 T8242 T8235 prep with,occurred
R4953 T8243 T8244 amod normal,activity
R4954 T8244 T8242 pobj activity,with
R4955 T8245 T8244 compound osteoclast,activity
R4956 T8246 T8235 punct ", ",occurred
R4957 T8247 T8248 mark as,assessed
R4958 T8248 T8235 advcl assessed,occurred
R4959 T8249 T8248 prep by,assessed
R4960 T8250 T8251 advmod in,vitro
R4961 T8251 T8252 amod vitro,culturing
R4962 T8252 T8249 pobj culturing,by
R4963 T8253 T8235 punct .,occurred
R4964 T8255 T8256 det These,observations
R4965 T8256 T8257 nsubj observations,are
R4966 T8258 T8257 acomp consistent,are
R4967 T8259 T8258 prep with,consistent
R4968 T8260 T8261 det the,mice
R4969 T8261 T8266 nsubj mice,having
R4970 T8262 T8261 nmod Sam68,mice
R4971 T8263 T8262 punct −,Sam68
R4972 T8264 T8262 punct /,Sam68
R4973 T8265 T8262 punct −,Sam68
R4974 T8266 T8259 pcomp having,with
R4975 T8267 T8268 det a,phenotype
R4976 T8268 T8266 dobj phenotype,having
R4977 T8269 T8270 npadvmod youth,like
R4978 T8270 T8268 amod like,phenotype
R4979 T8271 T8270 punct -,like
R4980 T8272 T8268 compound bone,phenotype
R4981 T8273 T8257 punct .,are
R4982 T8275 T8276 advmod However,is
R4983 T8277 T8276 punct ", ",is
R4984 T8278 T8276 nsubj it,is
R4985 T8279 T8276 advmod still,is
R4986 T8280 T8276 acomp possible,is
R4987 T8281 T8276 punct ", ",is
R4988 T8282 T8283 mark that,manifest
R4989 T8283 T8276 ccomp manifest,is
R4990 T8284 T8285 det a,impairment
R4991 T8285 T8283 nsubj impairment,manifest
R4992 T8286 T8285 amod mild,impairment
R4993 T8287 T8285 prep in,impairment
R4994 T8288 T8289 nmod Sam68,mice
R4995 T8289 T8293 compound mice,function
R4996 T8290 T8288 punct −,Sam68
R4997 T8291 T8288 punct /,Sam68
R4998 T8292 T8288 punct −,Sam68
R4999 T8293 T8287 pobj function,in
R5000 T8294 T8293 compound osteoclast,function
R5001 T8295 T8283 aux may,manifest
R5002 T8296 T8283 dobj itself,manifest
R5003 T8297 T8283 advmod later,manifest
R5004 T8298 T8297 prep in,later
R5005 T8299 T8298 pobj life,in
R5006 T8300 T8283 prep in,manifest
R5007 T8301 T8302 amod overall,accumulation
R5008 T8302 T8300 pobj accumulation,in
R5009 T8303 T8302 prep of,accumulation
R5010 T8304 T8303 pobj bone,of
R5011 T8305 T8276 cc and,is
R5012 T8306 T8307 nsubj this,require
R5013 T8307 T8276 conj require,is
R5014 T8308 T8307 aux will,require
R5015 T8309 T8310 amod further,studies
R5016 T8310 T8307 dobj studies,require
R5017 T8311 T8310 amod detailed,studies
R5018 T8312 T8276 punct .,is