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PMC:1315279 / 30985-38443 JSONTXT 5 Projects

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Id Subject Object Predicate Lexical cue
T7333 11-14 DT denotes The
T7335 15-22 JJ denotes present
T7334 23-28 NN denotes study
T7336 29-37 VBZ denotes provides
T7337 38-46 NN denotes evidence
T7338 47-51 IN denotes that
T7340 52-53 DT denotes a
T7342 54-65 JJ denotes physiologic
T7341 66-70 NN denotes role
T7343 71-73 IN denotes of
T7344 74-79 NN denotes Sam68
T7339 80-82 VBZ denotes is
T7345 83-85 TO denotes to
T7346 86-94 VB denotes modulate
T7347 95-99 NN denotes bone
T7348 100-106 NN denotes marrow
T7350 107-118 JJ denotes mesenchymal
T7351 119-123 NN denotes stem
T7349 124-129 NNS denotes cells
T7352 129-130 . denotes .
T7353 130-238 sentence denotes Young Sam68−/− mice developed normally and contained similar bone mass compared with wild-type littermates.
T7354 131-136 JJ denotes Young
T7356 137-142 NN denotes Sam68
T7357 142-143 SYM denotes −
T7358 143-144 HYPH denotes /
T7359 144-145 SYM denotes −
T7355 146-150 NNS denotes mice
T7360 151-160 VBD denotes developed
T7361 161-169 RB denotes normally
T7362 170-173 CC denotes and
T7363 174-183 VBD denotes contained
T7364 184-191 JJ denotes similar
T7366 192-196 NN denotes bone
T7365 197-201 NN denotes mass
T7367 202-210 VBN denotes compared
T7368 211-215 IN denotes with
T7369 216-220 JJ denotes wild
T7371 220-221 HYPH denotes -
T7370 221-225 NN denotes type
T7372 226-237 NNS denotes littermates
T7373 237-238 . denotes .
T7374 238-342 sentence denotes Aged (12 months) Sam68−/− mice displayed a high bone mass phenotype compared with Sam68+/+ littermates.
T7375 239-243 VBN denotes Aged
T7377 244-245 -LRB- denotes (
T7379 245-247 CD denotes 12
T7378 248-254 NNS denotes months
T7380 254-255 -RRB- denotes )
T7381 256-261 NN denotes Sam68
T7382 261-262 SYM denotes −
T7383 262-263 HYPH denotes /
T7384 263-264 SYM denotes −
T7376 265-269 NNS denotes mice
T7385 270-279 VBD denotes displayed
T7386 280-281 DT denotes a
T7388 282-286 JJ denotes high
T7390 287-291 NN denotes bone
T7389 292-296 NN denotes mass
T7387 297-306 NN denotes phenotype
T7391 307-315 VBN denotes compared
T7392 316-320 IN denotes with
T7393 321-326 NN denotes Sam68
T7395 326-327 SYM denotes +
T7396 327-328 HYPH denotes /
T7397 328-329 SYM denotes +
T7394 330-341 NNS denotes littermates
T7398 341-342 . denotes .
T7399 342-499 sentence denotes The wild-type littermates underwent age-related bone loss that occurs naturally in mammals, while the Sam68−/− animals preserved their bone mass with aging.
T7400 343-346 DT denotes The
T7402 347-351 JJ denotes wild
T7404 351-352 HYPH denotes -
T7403 352-356 NN denotes type
T7401 357-368 NNS denotes littermates
T7405 369-378 VBD denotes underwent
T7406 379-382 NN denotes age
T7408 382-383 HYPH denotes -
T7407 383-390 VBN denotes related
T7410 391-395 NN denotes bone
T7409 396-400 NN denotes loss
T7411 401-405 WDT denotes that
T7412 406-412 VBZ denotes occurs
T7413 413-422 RB denotes naturally
T7414 423-425 IN denotes in
T7415 426-433 NNS denotes mammals
T7416 433-435 , denotes ,
T7417 435-440 IN denotes while
T7419 441-444 DT denotes the
T7421 445-450 NN denotes Sam68
T7422 450-451 SYM denotes −
T7423 451-452 HYPH denotes /
T7424 452-453 SYM denotes −
T7420 454-461 NNS denotes animals
T7418 462-471 VBD denotes preserved
T7425 472-477 PRP$ denotes their
T7427 478-482 NN denotes bone
T7426 483-487 NN denotes mass
T7428 488-492 IN denotes with
T7429 493-498 NN denotes aging
T7430 498-499 . denotes .
T7431 499-724 sentence denotes The differentiation of bone marrow stem cells isolated from Sam68−/− mice and embryonic mesenchymal multipotential progenitor cells C3H10T1/2 treated with Sam68 shRNA resulted in a more pronounced osteoblast differentiation.
T7432 500-503 DT denotes The
T7433 504-519 NN denotes differentiation
T7435 520-522 IN denotes of
T7436 523-527 NN denotes bone
T7437 528-534 NN denotes marrow
T7439 535-539 NN denotes stem
T7438 540-545 NNS denotes cells
T7440 546-554 VBN denotes isolated
T7441 555-559 IN denotes from
T7442 560-565 NN denotes Sam68
T7444 565-566 SYM denotes −
T7445 566-567 HYPH denotes /
T7446 567-568 SYM denotes −
T7443 569-573 NNS denotes mice
T7447 574-577 CC denotes and
T7448 578-587 JJ denotes embryonic
T7450 588-599 JJ denotes mesenchymal
T7451 600-614 JJ denotes multipotential
T7452 615-625 NN denotes progenitor
T7449 626-631 NNS denotes cells
T7453 632-639 NN denotes C3H10T1
T7454 639-640 HYPH denotes /
T7455 640-641 CD denotes 2
T7456 642-649 VBN denotes treated
T7457 650-654 IN denotes with
T7458 655-660 NN denotes Sam68
T7459 661-666 NN denotes shRNA
T7434 667-675 VBD denotes resulted
T7460 676-678 IN denotes in
T7461 679-680 DT denotes a
T7463 681-685 RBR denotes more
T7464 686-696 JJ denotes pronounced
T7465 697-707 NN denotes osteoblast
T7462 708-723 NN denotes differentiation
T7466 723-724 . denotes .
T7467 724-811 sentence denotes These findings demonstrate that the loss of Sam68 enhances osteoblast differentiation.
T7468 725-730 DT denotes These
T7469 731-739 NNS denotes findings
T7470 740-751 VBP denotes demonstrate
T7471 752-756 IN denotes that
T7473 757-760 DT denotes the
T7474 761-765 NN denotes loss
T7475 766-768 IN denotes of
T7476 769-774 NN denotes Sam68
T7472 775-783 VBZ denotes enhances
T7477 784-794 NN denotes osteoblast
T7478 795-810 NN denotes differentiation
T7479 810-811 . denotes .
T7480 811-975 sentence denotes The converse was also true, as MEFs isolated from Sam68−/− animals were impaired in their ability to undergo adipocyte differentiation compared with Sam68+/+ MEFs.
T7481 812-815 DT denotes The
T7482 816-824 NN denotes converse
T7483 825-828 VBD denotes was
T7484 829-833 RB denotes also
T7485 834-838 JJ denotes true
T7486 838-840 , denotes ,
T7487 840-842 IN denotes as
T7489 843-847 NNS denotes MEFs
T7490 848-856 VBN denotes isolated
T7491 857-861 IN denotes from
T7492 862-867 NN denotes Sam68
T7494 867-868 SYM denotes −
T7495 868-869 HYPH denotes /
T7496 869-870 SYM denotes −
T7493 871-878 NNS denotes animals
T7497 879-883 VBD denotes were
T7488 884-892 VBN denotes impaired
T7498 893-895 IN denotes in
T7499 896-901 PRP$ denotes their
T7500 902-909 NN denotes ability
T7501 910-912 TO denotes to
T7502 913-920 VB denotes undergo
T7503 921-930 NN denotes adipocyte
T7504 931-946 NN denotes differentiation
T7505 947-955 VBN denotes compared
T7506 956-960 IN denotes with
T7507 961-966 NN denotes Sam68
T7509 966-967 SYM denotes +
T7510 967-968 HYPH denotes /
T7511 968-969 SYM denotes +
T7508 970-974 NNS denotes MEFs
T7512 974-975 . denotes .
T7513 975-1141 sentence denotes These findings suggest that a physiologic role for Sam68 is to regulate the balance between adipogenic and osteogenic differentiation of the bone marrow mesenchymal.
T7514 976-981 DT denotes These
T7515 982-990 NNS denotes findings
T7516 991-998 VBP denotes suggest
T7517 999-1003 IN denotes that
T7519 1004-1005 DT denotes a
T7521 1006-1017 JJ denotes physiologic
T7520 1018-1022 NN denotes role
T7522 1023-1026 IN denotes for
T7523 1027-1032 NN denotes Sam68
T7518 1033-1035 VBZ denotes is
T7524 1036-1038 TO denotes to
T7525 1039-1047 VB denotes regulate
T7526 1048-1051 DT denotes the
T7527 1052-1059 NN denotes balance
T7528 1060-1067 IN denotes between
T7529 1068-1078 JJ denotes adipogenic
T7531 1079-1082 CC denotes and
T7532 1083-1093 JJ denotes osteogenic
T7530 1094-1109 NN denotes differentiation
T7533 1110-1112 IN denotes of
T7534 1113-1116 DT denotes the
T7536 1117-1121 NN denotes bone
T7535 1122-1128 NN denotes marrow
T7537 1129-1140 JJ denotes mesenchymal
T7538 1140-1141 . denotes .
T7539 1141-1312 sentence denotes Sam68 protein expression was observed throughout the developing mouse embryo, in keeping with previous reports that identified the Sam68 mRNA to be widely expressed [38].
T7540 1142-1147 NN denotes Sam68
T7542 1148-1155 NN denotes protein
T7541 1156-1166 NN denotes expression
T7544 1167-1170 VBD denotes was
T7543 1171-1179 VBN denotes observed
T7545 1180-1190 IN denotes throughout
T7546 1191-1194 DT denotes the
T7548 1195-1205 VBG denotes developing
T7549 1206-1211 NN denotes mouse
T7547 1212-1218 NN denotes embryo
T7550 1218-1220 , denotes ,
T7551 1220-1222 IN denotes in
T7552 1223-1230 VBG denotes keeping
T7553 1231-1235 IN denotes with
T7554 1236-1244 JJ denotes previous
T7555 1245-1252 NNS denotes reports
T7556 1253-1257 WDT denotes that
T7557 1258-1268 VBD denotes identified
T7558 1269-1272 DT denotes the
T7560 1273-1278 NN denotes Sam68
T7559 1279-1283 NN denotes mRNA
T7562 1284-1286 TO denotes to
T7563 1287-1289 VB denotes be
T7564 1290-1296 RB denotes widely
T7561 1297-1306 VBN denotes expressed
T7565 1307-1308 -LRB- denotes [
T7566 1308-1310 CD denotes 38
T7567 1310-1311 -RRB- denotes ]
T7568 1311-1312 . denotes .
T7569 1312-1465 sentence denotes We observe Sam68 staining in the brain, heart, and intestine (see Figure 1) as well as liver, skin, and kidney (unpublished data) of late-stage embryos.
T7570 1313-1315 PRP denotes We
T7571 1316-1323 VBP denotes observe
T7572 1324-1329 NN denotes Sam68
T7573 1330-1338 NN denotes staining
T7574 1339-1341 IN denotes in
T7575 1342-1345 DT denotes the
T7576 1346-1351 NN denotes brain
T7577 1351-1353 , denotes ,
T7578 1353-1358 NN denotes heart
T7579 1358-1360 , denotes ,
T7580 1360-1363 CC denotes and
T7581 1364-1373 NN denotes intestine
T7582 1374-1375 -LRB- denotes (
T7583 1375-1378 VB denotes see
T7584 1379-1385 NN denotes Figure
T7585 1386-1387 CD denotes 1
T7586 1387-1388 -RRB- denotes )
T7587 1389-1391 RB denotes as
T7589 1392-1396 RB denotes well
T7588 1397-1399 IN denotes as
T7590 1400-1405 NN denotes liver
T7591 1405-1407 , denotes ,
T7592 1407-1411 NN denotes skin
T7593 1411-1413 , denotes ,
T7594 1413-1416 CC denotes and
T7595 1417-1423 NN denotes kidney
T7596 1424-1425 -LRB- denotes (
T7598 1425-1436 JJ denotes unpublished
T7597 1437-1441 NNS denotes data
T7599 1441-1442 -RRB- denotes )
T7600 1443-1445 IN denotes of
T7601 1446-1450 JJ denotes late
T7603 1450-1451 HYPH denotes -
T7602 1451-1456 NN denotes stage
T7604 1457-1464 NNS denotes embryos
T7605 1464-1465 . denotes .
T7606 1465-1629 sentence denotes This expression pattern is consistent with previous work that has observed Sam68 in neurons [52] and as a substrate of the intestinal SIK/breast tumor kinase [43].
T7607 1466-1470 DT denotes This
T7609 1471-1481 NN denotes expression
T7608 1482-1489 NN denotes pattern
T7610 1490-1492 VBZ denotes is
T7611 1493-1503 JJ denotes consistent
T7612 1504-1508 IN denotes with
T7613 1509-1517 JJ denotes previous
T7614 1518-1522 NN denotes work
T7615 1523-1527 WDT denotes that
T7617 1528-1531 VBZ denotes has
T7616 1532-1540 VBN denotes observed
T7618 1541-1546 NN denotes Sam68
T7619 1547-1549 IN denotes in
T7620 1550-1557 NNS denotes neurons
T7621 1558-1559 -LRB- denotes [
T7622 1559-1561 CD denotes 52
T7623 1561-1562 -RRB- denotes ]
T7624 1563-1566 CC denotes and
T7625 1567-1569 IN denotes as
T7626 1570-1571 DT denotes a
T7627 1572-1581 NN denotes substrate
T7628 1582-1584 IN denotes of
T7629 1585-1588 DT denotes the
T7631 1589-1599 JJ denotes intestinal
T7632 1600-1603 NN denotes SIK
T7633 1603-1604 HYPH denotes /
T7634 1604-1610 NN denotes breast
T7635 1611-1616 NN denotes tumor
T7630 1617-1623 NN denotes kinase
T7636 1624-1625 -LRB- denotes [
T7637 1625-1627 CD denotes 43
T7638 1627-1628 -RRB- denotes ]
T7639 1628-1629 . denotes .
T7640 1629-1755 sentence denotes The expression of Sam68 was not altered in aging bone marrow stromal cells or in senescencing WI-38 cells (unpublished data).
T7641 1630-1633 DT denotes The
T7642 1634-1644 NN denotes expression
T7644 1645-1647 IN denotes of
T7645 1648-1653 NN denotes Sam68
T7646 1654-1657 VBD denotes was
T7647 1658-1661 RB denotes not
T7643 1662-1669 VBN denotes altered
T7648 1670-1672 IN denotes in
T7649 1673-1678 VBG denotes aging
T7651 1679-1683 NN denotes bone
T7652 1684-1690 NN denotes marrow
T7653 1691-1698 JJ denotes stromal
T7650 1699-1704 NNS denotes cells
T7654 1705-1707 CC denotes or
T7655 1708-1710 IN denotes in
T7656 1711-1723 VBG denotes senescencing
T7658 1724-1726 NN denotes WI
T7659 1726-1727 HYPH denotes -
T7660 1727-1729 CD denotes 38
T7657 1730-1735 NNS denotes cells
T7661 1736-1737 -LRB- denotes (
T7663 1737-1748 JJ denotes unpublished
T7662 1749-1753 NNS denotes data
T7664 1753-1754 -RRB- denotes )
T7665 1754-1755 . denotes .
T7666 1755-1921 sentence denotes The presence of Sam68 in chondrocytes, osteoblasts and osteoclasts in developing cartilage and bone predicted a pivotal role for the protein in skeletal development.
T7667 1756-1759 DT denotes The
T7668 1760-1768 NN denotes presence
T7670 1769-1771 IN denotes of
T7671 1772-1777 NN denotes Sam68
T7672 1778-1780 IN denotes in
T7673 1781-1793 NNS denotes chondrocytes
T7674 1793-1795 , denotes ,
T7675 1795-1806 NNS denotes osteoblasts
T7676 1807-1810 CC denotes and
T7677 1811-1822 NNS denotes osteoclasts
T7678 1823-1825 IN denotes in
T7679 1826-1836 VBG denotes developing
T7680 1837-1846 NN denotes cartilage
T7681 1847-1850 CC denotes and
T7682 1851-1855 NN denotes bone
T7669 1856-1865 VBD denotes predicted
T7683 1866-1867 DT denotes a
T7685 1868-1875 JJ denotes pivotal
T7684 1876-1880 NN denotes role
T7686 1881-1884 IN denotes for
T7687 1885-1888 DT denotes the
T7688 1889-1896 NN denotes protein
T7689 1897-1899 IN denotes in
T7690 1900-1908 JJ denotes skeletal
T7691 1909-1920 NN denotes development
T7692 1920-1921 . denotes .
T7693 1921-2133 sentence denotes The Sam68−/− mice were generated using a traditional targeting approach where the functional KH domain was deleted and approximately one third of the Sam68−/− mice survived to adulthood with no apparent defects.
T7694 1922-1925 DT denotes The
T7696 1926-1931 NN denotes Sam68
T7697 1931-1932 SYM denotes −
T7698 1932-1933 HYPH denotes /
T7699 1933-1934 SYM denotes −
T7695 1935-1939 NNS denotes mice
T7701 1940-1944 VBD denotes were
T7700 1945-1954 VBN denotes generated
T7702 1955-1960 VBG denotes using
T7703 1961-1962 DT denotes a
T7705 1963-1974 JJ denotes traditional
T7706 1975-1984 NN denotes targeting
T7704 1985-1993 NN denotes approach
T7707 1994-1999 WRB denotes where
T7709 2000-2003 DT denotes the
T7711 2004-2014 JJ denotes functional
T7712 2015-2017 NN denotes KH
T7710 2018-2024 NN denotes domain
T7713 2025-2028 VBD denotes was
T7708 2029-2036 VBN denotes deleted
T7714 2037-2040 CC denotes and
T7715 2041-2054 RB denotes approximately
T7716 2055-2058 CD denotes one
T7718 2059-2064 JJ denotes third
T7719 2065-2067 IN denotes of
T7720 2068-2071 DT denotes the
T7722 2072-2077 NN denotes Sam68
T7723 2077-2078 SYM denotes −
T7724 2078-2079 HYPH denotes /
T7725 2079-2080 SYM denotes −
T7721 2081-2085 NNS denotes mice
T7717 2086-2094 VBD denotes survived
T7726 2095-2097 IN denotes to
T7727 2098-2107 NN denotes adulthood
T7728 2108-2112 IN denotes with
T7729 2113-2115 DT denotes no
T7731 2116-2124 JJ denotes apparent
T7730 2125-2132 NNS denotes defects
T7732 2132-2133 . denotes .
T7733 2133-2292 sentence denotes One explanation for this phenomenon is that Sam68 function is sub-served by one or more of its family members during development such as SLM-1 and SLM-2 [47].
T7734 2134-2137 CD denotes One
T7735 2138-2149 NN denotes explanation
T7737 2150-2153 IN denotes for
T7738 2154-2158 DT denotes this
T7739 2159-2169 NN denotes phenomenon
T7736 2170-2172 VBZ denotes is
T7740 2173-2177 IN denotes that
T7742 2178-2183 NN denotes Sam68
T7743 2184-2192 NN denotes function
T7744 2193-2195 VBZ denotes is
T7741 2196-2206 VBN denotes sub-served
T7745 2207-2209 IN denotes by
T7746 2210-2213 CD denotes one
T7747 2214-2216 CC denotes or
T7748 2217-2221 JJR denotes more
T7749 2222-2224 IN denotes of
T7750 2225-2228 PRP$ denotes its
T7752 2229-2235 NN denotes family
T7751 2236-2243 NNS denotes members
T7753 2244-2250 IN denotes during
T7754 2251-2262 NN denotes development
T7755 2263-2267 JJ denotes such
T7756 2268-2270 IN denotes as
T7757 2271-2274 NN denotes SLM
T7758 2274-2275 HYPH denotes -
T7759 2275-2276 CD denotes 1
T7760 2277-2280 CC denotes and
T7761 2281-2284 NN denotes SLM
T7762 2284-2285 HYPH denotes -
T7763 2285-2286 CD denotes 2
T7764 2287-2288 -LRB- denotes [
T7765 2288-2290 CD denotes 47
T7766 2290-2291 -RRB- denotes ]
T7767 2291-2292 . denotes .
T7768 2292-2359 sentence denotes Alternatively, Sam68 is not required during embryonic development.
T7769 2293-2306 RB denotes Alternatively
T7771 2306-2308 , denotes ,
T7772 2308-2313 NN denotes Sam68
T7773 2314-2316 VBZ denotes is
T7774 2317-2320 RB denotes not
T7770 2321-2329 VBN denotes required
T7775 2330-2336 IN denotes during
T7776 2337-2346 JJ denotes embryonic
T7777 2347-2358 NN denotes development
T7778 2358-2359 . denotes .
T7779 2359-2462 sentence denotes However, two thirds of the Sam68−/−, but not the Sam68+/- pups, were killed by their Sam68+/- mothers.
T7780 2360-2367 RB denotes However
T7782 2367-2369 , denotes ,
T7783 2369-2372 CD denotes two
T7784 2373-2379 NNS denotes thirds
T7785 2380-2382 IN denotes of
T7786 2383-2386 DT denotes the
T7787 2387-2392 NN denotes Sam68
T7788 2392-2393 SYM denotes −
T7789 2393-2394 HYPH denotes /
T7790 2394-2395 SYM denotes −
T7791 2395-2397 , denotes ,
T7792 2397-2400 CC denotes but
T7793 2401-2404 RB denotes not
T7794 2405-2408 DT denotes the
T7795 2409-2414 NN denotes Sam68
T7797 2414-2415 SYM denotes +
T7798 2415-2416 HYPH denotes /
T7799 2416-2417 SYM denotes -
T7796 2418-2422 NNS denotes pups
T7800 2422-2424 , denotes ,
T7801 2424-2428 VBD denotes were
T7781 2429-2435 VBN denotes killed
T7802 2436-2438 IN denotes by
T7803 2439-2444 PRP$ denotes their
T7805 2445-2450 NN denotes Sam68
T7806 2450-2451 SYM denotes +
T7807 2451-2452 HYPH denotes /
T7808 2452-2453 SYM denotes -
T7804 2454-2461 NNS denotes mothers
T7809 2461-2462 . denotes .
T7810 2462-2564 sentence denotes These findings suggest that the mothers are able to detect a subtle defect/difference that we cannot.
T7811 2463-2468 DT denotes These
T7812 2469-2477 NNS denotes findings
T7813 2478-2485 VBP denotes suggest
T7814 2486-2490 IN denotes that
T7816 2491-2494 DT denotes the
T7817 2495-2502 NNS denotes mothers
T7815 2503-2506 VBP denotes are
T7818 2507-2511 JJ denotes able
T7819 2512-2514 TO denotes to
T7820 2515-2521 VB denotes detect
T7821 2522-2523 DT denotes a
T7823 2524-2530 JJ denotes subtle
T7824 2531-2537 NN denotes defect
T7825 2537-2538 HYPH denotes /
T7822 2538-2548 NN denotes difference
T7826 2549-2553 WDT denotes that
T7828 2554-2556 PRP denotes we
T7827 2557-2560 MD denotes can
T7829 2560-2563 RB denotes not
T7830 2563-2564 . denotes .
T7831 2564-2636 sentence denotes Adult Sam68−/− mice live a normal life span of approximately two years.
T7832 2565-2570 JJ denotes Adult
T7834 2571-2576 NN denotes Sam68
T7835 2576-2577 SYM denotes −
T7836 2577-2578 HYPH denotes /
T7837 2578-2579 SYM denotes −
T7833 2580-2584 NNS denotes mice
T7838 2585-2589 VBP denotes live
T7839 2590-2591 DT denotes a
T7841 2592-2598 JJ denotes normal
T7842 2599-2603 NN denotes life
T7840 2604-2608 NN denotes span
T7843 2609-2611 IN denotes of
T7844 2612-2625 RB denotes approximately
T7845 2626-2629 CD denotes two
T7846 2630-2635 NNS denotes years
T7847 2635-2636 . denotes .
T7848 2636-2816 sentence denotes The Sam68−/− males were sterile and the Sam68−/− females provided inadequate care to their young, but the pups were not scattered and neglected as observed with FosB−/− mice [53].
T7849 2637-2640 DT denotes The
T7851 2641-2646 NN denotes Sam68
T7852 2646-2647 SYM denotes −
T7853 2647-2648 HYPH denotes /
T7854 2648-2649 SYM denotes −
T7850 2650-2655 NNS denotes males
T7855 2656-2660 VBD denotes were
T7856 2661-2668 JJ denotes sterile
T7857 2669-2672 CC denotes and
T7858 2673-2676 DT denotes the
T7860 2677-2682 NN denotes Sam68
T7861 2682-2683 SYM denotes −
T7862 2683-2684 HYPH denotes /
T7863 2684-2685 SYM denotes −
T7859 2686-2693 NNS denotes females
T7864 2694-2702 VBD denotes provided
T7865 2703-2713 JJ denotes inadequate
T7866 2714-2718 NN denotes care
T7867 2719-2721 IN denotes to
T7868 2722-2727 PRP$ denotes their
T7869 2728-2733 JJ denotes young
T7870 2733-2735 , denotes ,
T7871 2735-2738 CC denotes but
T7872 2739-2742 DT denotes the
T7873 2743-2747 NNS denotes pups
T7875 2748-2752 VBD denotes were
T7876 2753-2756 RB denotes not
T7874 2757-2766 VBN denotes scattered
T7877 2767-2770 CC denotes and
T7878 2771-2780 VBN denotes neglected
T7879 2781-2783 IN denotes as
T7880 2784-2792 VBN denotes observed
T7881 2793-2797 IN denotes with
T7882 2798-2802 NN denotes FosB
T7884 2802-2803 SYM denotes −
T7885 2803-2804 HYPH denotes /
T7886 2804-2805 SYM denotes −
T7883 2806-2810 NNS denotes mice
T7887 2811-2812 -LRB- denotes [
T7888 2812-2814 CD denotes 53
T7889 2814-2815 -RRB- denotes ]
T7890 2815-2816 . denotes .
T7891 2816-2953 sentence denotes Serum levels of estrogen decreased in aging Sam68−/− females as expected; however, the leptin levels decreased in aged Sam68−/− females.
T7892 2817-2822 NN denotes Serum
T7893 2823-2829 NNS denotes levels
T7895 2830-2832 IN denotes of
T7896 2833-2841 NN denotes estrogen
T7894 2842-2851 VBD denotes decreased
T7898 2852-2854 IN denotes in
T7899 2855-2860 VBG denotes aging
T7901 2861-2866 NN denotes Sam68
T7902 2866-2867 SYM denotes −
T7903 2867-2868 HYPH denotes /
T7904 2868-2869 SYM denotes −
T7900 2870-2877 NNS denotes females
T7905 2878-2880 IN denotes as
T7906 2881-2889 VBN denotes expected
T7907 2889-2890 : denotes ;
T7908 2891-2898 RB denotes however
T7909 2898-2900 , denotes ,
T7910 2900-2903 DT denotes the
T7912 2904-2910 NN denotes leptin
T7911 2911-2917 NNS denotes levels
T7897 2918-2927 VBD denotes decreased
T7913 2928-2930 IN denotes in
T7914 2931-2935 JJ denotes aged
T7916 2936-2941 NN denotes Sam68
T7917 2941-2942 SYM denotes −
T7918 2942-2943 HYPH denotes /
T7919 2943-2944 SYM denotes −
T7915 2945-2952 NNS denotes females
T7920 2952-2953 . denotes .
T7921 2953-3064 sentence denotes The aged Sam68−/− females were not obese and actually weighed less than the littermate controls (see Table 2).
T7922 2954-2957 DT denotes The
T7924 2958-2962 JJ denotes aged
T7925 2963-2968 NN denotes Sam68
T7926 2968-2969 SYM denotes −
T7927 2969-2970 HYPH denotes /
T7928 2970-2971 SYM denotes −
T7923 2972-2979 NNS denotes females
T7929 2980-2984 VBD denotes were
T7930 2985-2988 RB denotes not
T7931 2989-2994 JJ denotes obese
T7932 2995-2998 CC denotes and
T7933 2999-3007 RB denotes actually
T7934 3008-3015 VBD denotes weighed
T7935 3016-3020 JJR denotes less
T7936 3021-3025 IN denotes than
T7937 3026-3029 DT denotes the
T7939 3030-3040 NN denotes littermate
T7938 3041-3049 NNS denotes controls
T7940 3050-3051 -LRB- denotes (
T7941 3051-3054 VB denotes see
T7942 3055-3060 NN denotes Table
T7943 3061-3062 CD denotes 2
T7944 3062-3063 -RRB- denotes )
T7945 3063-3064 . denotes .
T7946 3064-3304 sentence denotes Moreover, their appetite was not altered with aging (N. Torabi and S. Richard, unpublished data), suggesting that the observed leptin reduction was not recreating ob/ob-like phenotypes related to weight, appetite and female sterility [54].
T7947 3065-3073 RB denotes Moreover
T7949 3073-3075 , denotes ,
T7950 3075-3080 PRP$ denotes their
T7951 3081-3089 NN denotes appetite
T7952 3090-3093 VBD denotes was
T7953 3094-3097 RB denotes not
T7948 3098-3105 VBN denotes altered
T7954 3106-3110 IN denotes with
T7955 3111-3116 NN denotes aging
T7956 3117-3118 -LRB- denotes (
T7957 3118-3120 NNP denotes N.
T7958 3121-3127 NNP denotes Torabi
T7959 3128-3131 CC denotes and
T7960 3132-3134 NNP denotes S.
T7961 3135-3142 NNP denotes Richard
T7962 3142-3144 , denotes ,
T7963 3144-3155 JJ denotes unpublished
T7964 3156-3160 NNS denotes data
T7965 3160-3161 -RRB- denotes )
T7966 3161-3163 , denotes ,
T7967 3163-3173 VBG denotes suggesting
T7968 3174-3178 IN denotes that
T7970 3179-3182 DT denotes the
T7972 3183-3191 VBN denotes observed
T7973 3192-3198 NN denotes leptin
T7971 3199-3208 NN denotes reduction
T7974 3209-3212 VBD denotes was
T7975 3213-3216 RB denotes not
T7969 3217-3227 VBG denotes recreating
T7976 3228-3230 NN denotes ob
T7978 3230-3231 HYPH denotes /
T7979 3231-3233 NN denotes ob
T7980 3233-3234 HYPH denotes -
T7977 3234-3238 JJ denotes like
T7981 3239-3249 NNS denotes phenotypes
T7982 3250-3257 VBN denotes related
T7983 3258-3260 IN denotes to
T7984 3261-3267 NN denotes weight
T7985 3267-3269 , denotes ,
T7986 3269-3277 NN denotes appetite
T7987 3278-3281 CC denotes and
T7988 3282-3288 JJ denotes female
T7989 3289-3298 NN denotes sterility
T7990 3299-3300 -LRB- denotes [
T7991 3300-3302 CD denotes 54
T7992 3302-3303 -RRB- denotes ]
T7993 3303-3304 . denotes .
T7994 3304-3429 sentence denotes The skeletal phenotyping of cohorts of Sam68+/+ and Sam68−/− mice showed that bone mass was preserved in aged Sam68−/− mice.
T7995 3305-3308 DT denotes The
T7997 3309-3317 JJ denotes skeletal
T7996 3318-3329 NN denotes phenotyping
T7999 3330-3332 IN denotes of
T8000 3333-3340 NNS denotes cohorts
T8001 3341-3343 IN denotes of
T8002 3344-3349 NN denotes Sam68
T8004 3349-3350 SYM denotes +
T8005 3350-3351 HYPH denotes /
T8006 3351-3352 SYM denotes +
T8007 3353-3356 CC denotes and
T8008 3357-3362 NN denotes Sam68
T8009 3362-3363 SYM denotes −
T8010 3363-3364 HYPH denotes /
T8011 3364-3365 SYM denotes −
T8003 3366-3370 NNS denotes mice
T7998 3371-3377 VBD denotes showed
T8012 3378-3382 IN denotes that
T8014 3383-3387 NN denotes bone
T8015 3388-3392 NN denotes mass
T8016 3393-3396 VBD denotes was
T8013 3397-3406 VBN denotes preserved
T8017 3407-3409 IN denotes in
T8018 3410-3414 JJ denotes aged
T8020 3415-3420 NN denotes Sam68
T8021 3420-3421 SYM denotes −
T8022 3421-3422 HYPH denotes /
T8023 3422-3423 SYM denotes −
T8019 3424-3428 NNS denotes mice
T8024 3428-3429 . denotes .
T8025 3429-3562 sentence denotes Traditional histology and histomorphometry suggested that the mechanism involved preservation of osteoblast and osteoclast activity.
T8026 3430-3441 JJ denotes Traditional
T8027 3442-3451 NN denotes histology
T8029 3452-3455 CC denotes and
T8030 3456-3472 NN denotes histomorphometry
T8028 3473-3482 VBD denotes suggested
T8031 3483-3487 IN denotes that
T8033 3488-3491 DT denotes the
T8034 3492-3501 NN denotes mechanism
T8032 3502-3510 VBD denotes involved
T8035 3511-3523 NN denotes preservation
T8036 3524-3526 IN denotes of
T8037 3527-3537 NN denotes osteoblast
T8039 3538-3541 CC denotes and
T8040 3542-3552 NN denotes osteoclast
T8038 3553-3561 NN denotes activity
T8041 3561-3562 DT denotes .
T8042 3562-3720 sentence denotes The documented role of the Sam68 regulatory protein, Src, in osteopetrosis led us to investigate the morphology and activity of Sam68−/− osteoclasts ex vivo.
T8043 3563-3566 DT denotes The
T8045 3567-3577 VBN denotes documented
T8044 3578-3582 NN denotes role
T8047 3583-3585 IN denotes of
T8048 3586-3589 DT denotes the
T8050 3590-3595 NN denotes Sam68
T8051 3596-3606 JJ denotes regulatory
T8049 3607-3614 NN denotes protein
T8052 3614-3616 , denotes ,
T8053 3616-3619 NN denotes Src
T8054 3619-3621 , denotes ,
T8055 3621-3623 IN denotes in
T8056 3624-3637 NN denotes osteopetrosis
T8046 3638-3641 VBD denotes led
T8057 3642-3644 PRP denotes us
T8058 3645-3647 TO denotes to
T8059 3648-3659 VB denotes investigate
T8060 3660-3663 DT denotes the
T8061 3664-3674 NN denotes morphology
T8062 3675-3678 CC denotes and
T8063 3679-3687 NN denotes activity
T8064 3688-3690 IN denotes of
T8065 3691-3696 NN denotes Sam68
T8067 3696-3697 SYM denotes −
T8068 3697-3698 HYPH denotes /
T8069 3698-3699 SYM denotes −
T8066 3700-3711 NNS denotes osteoclasts
T8070 3712-3714 FW denotes ex
T8071 3715-3719 FW denotes vivo
T8072 3719-3720 . denotes .
T8073 3720-3938 sentence denotes The Src tyrosine kinase was shown to play a role in bone remodeling when Src−/− mice died at 6 months of age with an osteopetrotic phenotype [48] and the defect was attributed to defective osteoclast function [55−59].
T8074 3721-3724 DT denotes The
T8076 3725-3728 NN denotes Src
T8077 3729-3737 NN denotes tyrosine
T8075 3738-3744 NN denotes kinase
T8079 3745-3748 VBD denotes was
T8078 3749-3754 VBN denotes shown
T8080 3755-3757 TO denotes to
T8081 3758-3762 VB denotes play
T8082 3763-3764 DT denotes a
T8083 3765-3769 NN denotes role
T8084 3770-3772 IN denotes in
T8085 3773-3777 NN denotes bone
T8086 3778-3788 NN denotes remodeling
T8087 3789-3793 WRB denotes when
T8089 3794-3797 NN denotes Src
T8091 3797-3798 SYM denotes −
T8092 3798-3799 HYPH denotes /
T8093 3799-3800 SYM denotes −
T8090 3801-3805 NNS denotes mice
T8088 3806-3810 VBD denotes died
T8094 3811-3813 IN denotes at
T8095 3814-3815 CD denotes 6
T8096 3816-3822 NNS denotes months
T8097 3823-3825 IN denotes of
T8098 3826-3829 NN denotes age
T8099 3830-3834 IN denotes with
T8100 3835-3837 DT denotes an
T8102 3838-3851 JJ denotes osteopetrotic
T8101 3852-3861 NN denotes phenotype
T8103 3862-3863 -LRB- denotes [
T8104 3863-3865 CD denotes 48
T8105 3865-3866 -RRB- denotes ]
T8106 3867-3870 CC denotes and
T8107 3871-3874 DT denotes the
T8108 3875-3881 NN denotes defect
T8110 3882-3885 VBD denotes was
T8109 3886-3896 VBN denotes attributed
T8111 3897-3899 IN denotes to
T8112 3900-3909 JJ denotes defective
T8114 3910-3920 NN denotes osteoclast
T8113 3921-3929 NN denotes function
T8115 3930-3931 -LRB- denotes [
T8116 3931-3933 CD denotes 55
T8117 3933-3934 SYM denotes −
T8118 3934-3936 CD denotes 59
T8119 3936-3937 -RRB- denotes ]
T8120 3937-3938 . denotes .
T8121 3938-4085 sentence denotes We therefore cultured mature osteoclasts harvested from Sam68+/+ and Sam68−/− mice ex vivo on dentin slices to quantify their resorptive capacity.
T8122 3939-3941 PRP denotes We
T8124 3942-3951 RB denotes therefore
T8123 3952-3960 VBD denotes cultured
T8125 3961-3967 JJ denotes mature
T8126 3968-3979 NNS denotes osteoclasts
T8127 3980-3989 VBN denotes harvested
T8128 3990-3994 IN denotes from
T8129 3995-4000 NN denotes Sam68
T8131 4000-4001 SYM denotes +
T8132 4001-4002 HYPH denotes /
T8133 4002-4003 SYM denotes +
T8134 4004-4007 CC denotes and
T8135 4008-4013 NN denotes Sam68
T8136 4013-4014 SYM denotes −
T8137 4014-4015 HYPH denotes /
T8138 4015-4016 SYM denotes −
T8130 4017-4021 NNS denotes mice
T8139 4022-4024 FW denotes ex
T8140 4025-4029 FW denotes vivo
T8141 4030-4032 IN denotes on
T8142 4033-4039 NN denotes dentin
T8143 4040-4046 NNS denotes slices
T8144 4047-4049 TO denotes to
T8145 4050-4058 VB denotes quantify
T8146 4059-4064 PRP$ denotes their
T8148 4065-4075 JJ denotes resorptive
T8147 4076-4084 NN denotes capacity
T8149 4084-4085 . denotes .
T8150 4085-4301 sentence denotes The fact that Sam68−/− osteoclasts looked and acted like Sam68+/+ osteoclasts ex vivo and in vivo made it unlikely that this was the primary source of the difference in bone metabolism in 12-month-old Sam68−/− mice.
T8151 4086-4089 DT denotes The
T8152 4090-4094 NN denotes fact
T8154 4095-4099 IN denotes that
T8156 4100-4105 NN denotes Sam68
T8158 4105-4106 SYM denotes −
T8159 4106-4107 HYPH denotes /
T8160 4107-4108 SYM denotes −
T8157 4109-4120 NNS denotes osteoclasts
T8155 4121-4127 VBD denotes looked
T8161 4128-4131 CC denotes and
T8162 4132-4137 VBD denotes acted
T8163 4138-4142 IN denotes like
T8164 4143-4148 NN denotes Sam68
T8166 4148-4149 SYM denotes +
T8167 4149-4150 HYPH denotes /
T8168 4150-4151 SYM denotes +
T8165 4152-4163 NNS denotes osteoclasts
T8169 4164-4166 FW denotes ex
T8170 4167-4171 FW denotes vivo
T8171 4172-4175 CC denotes and
T8172 4176-4178 FW denotes in
T8173 4179-4183 FW denotes vivo
T8153 4184-4188 VBD denotes made
T8174 4189-4191 PRP denotes it
T8175 4192-4200 JJ denotes unlikely
T8176 4201-4205 IN denotes that
T8178 4206-4210 DT denotes this
T8177 4211-4214 VBD denotes was
T8179 4215-4218 DT denotes the
T8181 4219-4226 JJ denotes primary
T8180 4227-4233 NN denotes source
T8182 4234-4236 IN denotes of
T8183 4237-4240 DT denotes the
T8184 4241-4251 NN denotes difference
T8185 4252-4254 IN denotes in
T8186 4255-4259 NN denotes bone
T8187 4260-4270 NN denotes metabolism
T8188 4271-4273 IN denotes in
T8189 4274-4276 CD denotes 12
T8191 4276-4277 HYPH denotes -
T8190 4277-4282 NN denotes month
T8193 4282-4283 HYPH denotes -
T8192 4283-4286 JJ denotes old
T8195 4287-4292 NN denotes Sam68
T8196 4292-4293 SYM denotes −
T8197 4293-4294 HYPH denotes /
T8198 4294-4295 SYM denotes −
T8194 4296-4300 NNS denotes mice
T8199 4300-4301 . denotes .
T8200 4301-4465 sentence denotes The fact that the CTX levels were lower in young and old Sam68−/− mice suggested that there is reduced bone resorption compared with wild-type littermate controls.
T8201 4302-4305 DT denotes The
T8202 4306-4310 NN denotes fact
T8204 4311-4315 IN denotes that
T8206 4316-4319 DT denotes the
T8208 4320-4323 NN denotes CTX
T8207 4324-4330 NNS denotes levels
T8205 4331-4335 VBD denotes were
T8209 4336-4341 JJR denotes lower
T8210 4342-4344 IN denotes in
T8211 4345-4350 JJ denotes young
T8213 4351-4354 CC denotes and
T8214 4355-4358 JJ denotes old
T8215 4359-4364 NN denotes Sam68
T8216 4364-4365 SYM denotes −
T8217 4365-4366 HYPH denotes /
T8218 4366-4367 SYM denotes −
T8212 4368-4372 NNS denotes mice
T8203 4373-4382 VBD denotes suggested
T8219 4383-4387 IN denotes that
T8221 4388-4393 EX denotes there
T8220 4394-4396 VBZ denotes is
T8222 4397-4404 VBN denotes reduced
T8224 4405-4409 NN denotes bone
T8223 4410-4420 NN denotes resorption
T8225 4421-4429 VBN denotes compared
T8226 4430-4434 IN denotes with
T8227 4435-4439 JJ denotes wild
T8229 4439-4440 HYPH denotes -
T8228 4440-4444 NN denotes type
T8231 4445-4455 NN denotes littermate
T8230 4456-4464 NNS denotes controls
T8232 4464-4465 . denotes .
T8233 4465-4585 sentence denotes However, this reduction in bone resorption occurred with normal osteoclast activity, as assessed by in vitro culturing.
T8234 4466-4473 RB denotes However
T8236 4473-4475 , denotes ,
T8237 4475-4479 DT denotes this
T8238 4480-4489 NN denotes reduction
T8239 4490-4492 IN denotes in
T8240 4493-4497 NN denotes bone
T8241 4498-4508 NN denotes resorption
T8235 4509-4517 VBD denotes occurred
T8242 4518-4522 IN denotes with
T8243 4523-4529 JJ denotes normal
T8245 4530-4540 NN denotes osteoclast
T8244 4541-4549 NN denotes activity
T8246 4549-4551 , denotes ,
T8247 4551-4553 IN denotes as
T8248 4554-4562 VBN denotes assessed
T8249 4563-4565 IN denotes by
T8250 4566-4568 FW denotes in
T8251 4569-4574 FW denotes vitro
T8252 4575-4584 NN denotes culturing
T8253 4584-4585 . denotes .
T8254 4585-4678 sentence denotes These observations are consistent with the Sam68−/− mice having a youth-like bone phenotype.
T8255 4586-4591 DT denotes These
T8256 4592-4604 NNS denotes observations
T8257 4605-4608 VBP denotes are
T8258 4609-4619 JJ denotes consistent
T8259 4620-4624 IN denotes with
T8260 4625-4628 DT denotes the
T8262 4629-4634 NN denotes Sam68
T8263 4634-4635 SYM denotes −
T8264 4635-4636 HYPH denotes /
T8265 4636-4637 SYM denotes −
T8261 4638-4642 NNS denotes mice
T8266 4643-4649 VBG denotes having
T8267 4650-4651 DT denotes a
T8269 4652-4657 NN denotes youth
T8271 4657-4658 HYPH denotes -
T8270 4658-4662 JJ denotes like
T8272 4663-4667 NN denotes bone
T8268 4668-4677 NN denotes phenotype
T8273 4677-4678 . denotes .
T8274 4678-4883 sentence denotes However, it is still possible, that a mild impairment in Sam68−/− mice osteoclast function may manifest itself later in life in overall accumulation of bone and this will require further detailed studies.
T8275 4679-4686 RB denotes However
T8277 4686-4688 , denotes ,
T8278 4688-4690 PRP denotes it
T8276 4691-4693 VBZ denotes is
T8279 4694-4699 RB denotes still
T8280 4700-4708 JJ denotes possible
T8281 4708-4710 , denotes ,
T8282 4710-4714 IN denotes that
T8284 4715-4716 DT denotes a
T8286 4717-4721 JJ denotes mild
T8285 4722-4732 NN denotes impairment
T8287 4733-4735 IN denotes in
T8288 4736-4741 NN denotes Sam68
T8290 4741-4742 SYM denotes −
T8291 4742-4743 HYPH denotes /
T8292 4743-4744 SYM denotes −
T8289 4745-4749 NNS denotes mice
T8294 4750-4760 NN denotes osteoclast
T8293 4761-4769 NN denotes function
T8295 4770-4773 MD denotes may
T8283 4774-4782 VB denotes manifest
T8296 4783-4789 PRP denotes itself
T8297 4790-4795 RB denotes later
T8298 4796-4798 IN denotes in
T8299 4799-4803 NN denotes life
T8300 4804-4806 IN denotes in
T8301 4807-4814 JJ denotes overall
T8302 4815-4827 NN denotes accumulation
T8303 4828-4830 IN denotes of
T8304 4831-4835 NN denotes bone
T8305 4836-4839 CC denotes and
T8306 4840-4844 DT denotes this
T8308 4845-4849 MD denotes will
T8307 4850-4857 VB denotes require
T8309 4858-4865 JJ denotes further
T8311 4866-4874 JJ denotes detailed
T8310 4875-4882 NNS denotes studies
T8312 4882-4883 . denotes .
T8313 4883-5106 sentence denotes Ex vivo differentiation of primary bone marrow stromal cells, harvested from Sam68+/+ and Sam68−/− mice, down the osteoblast lineage revealed an osteogenic advantage in the cultures of cells derived from the Sam68−/− mice.
T8314 4884-4886 FW denotes Ex
T8315 4887-4891 FW denotes vivo
T8316 4892-4907 NN denotes differentiation
T8318 4908-4910 IN denotes of
T8319 4911-4918 JJ denotes primary
T8321 4919-4923 NN denotes bone
T8322 4924-4930 NN denotes marrow
T8323 4931-4938 JJ denotes stromal
T8320 4939-4944 NNS denotes cells
T8324 4944-4946 , denotes ,
T8325 4946-4955 VBN denotes harvested
T8326 4956-4960 IN denotes from
T8327 4961-4966 NN denotes Sam68
T8329 4966-4967 SYM denotes +
T8330 4967-4968 HYPH denotes /
T8331 4968-4969 SYM denotes +
T8332 4970-4973 CC denotes and
T8333 4974-4979 NN denotes Sam68
T8334 4979-4980 SYM denotes −
T8335 4980-4981 HYPH denotes /
T8336 4981-4982 SYM denotes −
T8328 4983-4987 NNS denotes mice
T8337 4987-4989 , denotes ,
T8338 4989-4993 IN denotes down
T8339 4994-4997 DT denotes the
T8341 4998-5008 NN denotes osteoblast
T8340 5009-5016 NN denotes lineage
T8317 5017-5025 VBD denotes revealed
T8342 5026-5028 DT denotes an
T8344 5029-5039 JJ denotes osteogenic
T8343 5040-5049 NN denotes advantage
T8345 5050-5052 IN denotes in
T8346 5053-5056 DT denotes the
T8347 5057-5065 NNS denotes cultures
T8348 5066-5068 IN denotes of
T8349 5069-5074 NNS denotes cells
T8350 5075-5082 VBN denotes derived
T8351 5083-5087 IN denotes from
T8352 5088-5091 DT denotes the
T8354 5092-5097 NN denotes Sam68
T8355 5097-5098 SYM denotes −
T8356 5098-5099 HYPH denotes /
T8357 5099-5100 SYM denotes −
T8353 5101-5105 NNS denotes mice
T8358 5105-5106 . denotes .
T8359 5106-5241 sentence denotes It will be important to demonstrate that a similar effect is observed using primary bone marrow stromal cells from aged Sam68−/− mice.
T8360 5107-5109 PRP denotes It
T8362 5110-5114 MD denotes will
T8361 5115-5117 VB denotes be
T8363 5118-5127 JJ denotes important
T8364 5128-5130 TO denotes to
T8365 5131-5142 VB denotes demonstrate
T8366 5143-5147 IN denotes that
T8368 5148-5149 DT denotes a
T8370 5150-5157 JJ denotes similar
T8369 5158-5164 NN denotes effect
T8371 5165-5167 VBZ denotes is
T8367 5168-5176 VBN denotes observed
T8372 5177-5182 VBG denotes using
T8373 5183-5190 JJ denotes primary
T8375 5191-5195 NN denotes bone
T8376 5196-5202 NN denotes marrow
T8377 5203-5210 JJ denotes stromal
T8374 5211-5216 NNS denotes cells
T8378 5217-5221 IN denotes from
T8379 5222-5226 JJ denotes aged
T8381 5227-5232 NN denotes Sam68
T8382 5232-5233 SYM denotes −
T8383 5233-5234 HYPH denotes /
T8384 5234-5235 SYM denotes −
T8380 5236-5240 NNS denotes mice
T8385 5240-5241 . denotes .
T8386 5241-5415 sentence denotes Similar findings were observed when embryonic mesenchymal multipotential progenitor cells C3H10T1/2 treated with Sam68 shRNA, were differentiated into osteoblasts with BMP2.
T8387 5242-5249 JJ denotes Similar
T8388 5250-5258 NNS denotes findings
T8390 5259-5263 VBD denotes were
T8389 5264-5272 VBN denotes observed
T8391 5273-5277 WRB denotes when
T8393 5278-5287 JJ denotes embryonic
T8395 5288-5299 JJ denotes mesenchymal
T8396 5300-5314 JJ denotes multipotential
T8397 5315-5325 NN denotes progenitor
T8394 5326-5331 NNS denotes cells
T8398 5332-5339 NN denotes C3H10T1
T8399 5339-5340 HYPH denotes /
T8400 5340-5341 CD denotes 2
T8401 5342-5349 VBN denotes treated
T8402 5350-5354 IN denotes with
T8403 5355-5360 NN denotes Sam68
T8404 5361-5366 NN denotes shRNA
T8405 5366-5368 , denotes ,
T8406 5368-5372 VBD denotes were
T8392 5373-5387 VBN denotes differentiated
T8407 5388-5392 IN denotes into
T8408 5393-5404 NNS denotes osteoblasts
T8409 5405-5409 IN denotes with
T8410 5410-5414 NN denotes BMP2
T8411 5414-5415 . denotes .
T8412 5415-5645 sentence denotes Our findings that aged Sam68−/− mice do not develop fatty bone marrow and that MEFs derived from Sam68 −/− mice have impaired adipocyte differentiation, indicate that Sam68 regulates both adipocyte and osteoblast differentiation.
T8413 5416-5419 PRP$ denotes Our
T8414 5420-5428 NNS denotes findings
T8416 5429-5433 IN denotes that
T8418 5434-5438 JJ denotes aged
T8420 5439-5444 NN denotes Sam68
T8421 5444-5445 SYM denotes −
T8422 5445-5446 HYPH denotes /
T8423 5446-5447 SYM denotes −
T8419 5448-5452 NNS denotes mice
T8424 5453-5455 VBP denotes do
T8425 5456-5459 RB denotes not
T8417 5460-5467 VB denotes develop
T8426 5468-5473 JJ denotes fatty
T8428 5474-5478 NN denotes bone
T8427 5479-5485 NN denotes marrow
T8429 5486-5489 CC denotes and
T8430 5490-5494 IN denotes that
T8432 5495-5499 NNS denotes MEFs
T8433 5500-5507 VBN denotes derived
T8434 5508-5512 IN denotes from
T8435 5513-5518 NN denotes Sam68
T8437 5519-5520 SYM denotes −
T8438 5520-5521 HYPH denotes /
T8439 5521-5522 SYM denotes −
T8436 5523-5527 NNS denotes mice
T8431 5528-5532 VBP denotes have
T8440 5533-5541 VBN denotes impaired
T8442 5542-5551 NN denotes adipocyte
T8441 5552-5567 NN denotes differentiation
T8443 5567-5569 , denotes ,
T8415 5569-5577 VBP denotes indicate
T8444 5578-5582 IN denotes that
T8446 5583-5588 NN denotes Sam68
T8445 5589-5598 VBZ denotes regulates
T8447 5599-5603 CC denotes both
T8448 5604-5613 NN denotes adipocyte
T8450 5614-5617 CC denotes and
T8451 5618-5628 NN denotes osteoblast
T8449 5629-5644 NN denotes differentiation
T8452 5644-5645 . denotes .
T8453 5645-5855 sentence denotes These findings identify Sam68 as the first RNA binding protein to regulate mesenchymal cell differentiation and the challenge will be to identify the specific RNA targets that it regulates during this process.
T8454 5646-5651 DT denotes These
T8455 5652-5660 NNS denotes findings
T8456 5661-5669 VBP denotes identify
T8457 5670-5675 NN denotes Sam68
T8458 5676-5678 IN denotes as
T8459 5679-5682 DT denotes the
T8461 5683-5688 JJ denotes first
T8462 5689-5692 NN denotes RNA
T8463 5693-5700 VBG denotes binding
T8460 5701-5708 NN denotes protein
T8464 5709-5711 TO denotes to
T8465 5712-5720 VB denotes regulate
T8466 5721-5732 JJ denotes mesenchymal
T8468 5733-5737 NN denotes cell
T8467 5738-5753 NN denotes differentiation
T8469 5754-5757 CC denotes and
T8470 5758-5761 DT denotes the
T8471 5762-5771 NN denotes challenge
T8473 5772-5776 MD denotes will
T8472 5777-5779 VB denotes be
T8474 5780-5782 TO denotes to
T8475 5783-5791 VB denotes identify
T8476 5792-5795 DT denotes the
T8478 5796-5804 JJ denotes specific
T8479 5805-5808 NN denotes RNA
T8477 5809-5816 NNS denotes targets
T8480 5817-5821 WDT denotes that
T8482 5822-5824 PRP denotes it
T8481 5825-5834 VBZ denotes regulates
T8483 5835-5841 IN denotes during
T8484 5842-5846 DT denotes this
T8485 5847-5854 NN denotes process
T8486 5854-5855 . denotes .
T8487 5855-6041 sentence denotes The fact that osteoblast function is altered in Src−/− mice [60,61] raises the possibility that preservation of bone mass in the Sam68−/− mice could be linked with and regulated by Src.
T8488 5856-5859 DT denotes The
T8489 5860-5864 NN denotes fact
T8491 5865-5869 IN denotes that
T8493 5870-5880 NN denotes osteoblast
T8494 5881-5889 NN denotes function
T8495 5890-5892 VBZ denotes is
T8492 5893-5900 VBN denotes altered
T8496 5901-5903 IN denotes in
T8497 5904-5907 NN denotes Src
T8499 5907-5908 SYM denotes −
T8500 5908-5909 HYPH denotes /
T8501 5909-5910 SYM denotes −
T8498 5911-5915 NNS denotes mice
T8502 5916-5917 -LRB- denotes [
T8504 5917-5919 CD denotes 60
T8505 5919-5920 , denotes ,
T8503 5920-5922 CD denotes 61
T8506 5922-5923 -RRB- denotes ]
T8490 5924-5930 VBZ denotes raises
T8507 5931-5934 DT denotes the
T8508 5935-5946 NN denotes possibility
T8509 5947-5951 IN denotes that
T8511 5952-5964 NN denotes preservation
T8512 5965-5967 IN denotes of
T8513 5968-5972 NN denotes bone
T8514 5973-5977 NN denotes mass
T8515 5978-5980 IN denotes in
T8516 5981-5984 DT denotes the
T8518 5985-5990 NN denotes Sam68
T8519 5990-5991 SYM denotes −
T8520 5991-5992 HYPH denotes /
T8521 5992-5993 SYM denotes −
T8517 5994-5998 NNS denotes mice
T8522 5999-6004 MD denotes could
T8523 6005-6007 VB denotes be
T8510 6008-6014 VBN denotes linked
T8524 6015-6019 IN denotes with
T8525 6020-6023 CC denotes and
T8526 6024-6033 VBN denotes regulated
T8527 6034-6036 IN denotes by
T8528 6037-6040 NN denotes Src
T8529 6040-6041 . denotes .
T8530 6041-6315 sentence denotes The pathway by which leptin regulates bone resorption was identified to involve the sympathetic nervous system relaying to the osteoblasts via the β-adrenergic pathway leading to the release of growth factors including RANKL that causes the osteoclasts to thrive [8,18–20].
T8531 6042-6045 DT denotes The
T8532 6046-6053 NN denotes pathway
T8534 6054-6056 IN denotes by
T8536 6057-6062 WDT denotes which
T8537 6063-6069 NN denotes leptin
T8535 6070-6079 VBZ denotes regulates
T8538 6080-6084 NN denotes bone
T8539 6085-6095 NN denotes resorption
T8540 6096-6099 VBD denotes was
T8533 6100-6110 VBN denotes identified
T8541 6111-6113 TO denotes to
T8542 6114-6121 VB denotes involve
T8543 6122-6125 DT denotes the
T8545 6126-6137 JJ denotes sympathetic
T8546 6138-6145 JJ denotes nervous
T8544 6146-6152 NN denotes system
T8547 6153-6161 VBG denotes relaying
T8548 6162-6164 IN denotes to
T8549 6165-6168 DT denotes the
T8550 6169-6180 NNS denotes osteoblasts
T8551 6181-6184 IN denotes via
T8552 6185-6188 DT denotes the
T8554 6189-6190 NN denotes β
T8556 6190-6191 HYPH denotes -
T8555 6191-6201 JJ denotes adrenergic
T8553 6202-6209 NN denotes pathway
T8557 6210-6217 VBG denotes leading
T8558 6218-6220 IN denotes to
T8559 6221-6224 DT denotes the
T8560 6225-6232 NN denotes release
T8561 6233-6235 IN denotes of
T8562 6236-6242 NN denotes growth
T8563 6243-6250 NNS denotes factors
T8564 6251-6260 VBG denotes including
T8565 6261-6266 NN denotes RANKL
T8566 6267-6271 WDT denotes that
T8567 6272-6278 VBZ denotes causes
T8568 6279-6282 DT denotes the
T8569 6283-6294 NNS denotes osteoclasts
T8571 6295-6297 TO denotes to
T8570 6298-6304 VB denotes thrive
T8572 6305-6306 -LRB- denotes [
T8573 6306-6307 CD denotes 8
T8574 6307-6308 , denotes ,
T8575 6308-6310 CD denotes 18
T8576 6310-6311 SYM denotes –
T8577 6311-6313 CD denotes 20
T8578 6313-6314 -RRB- denotes ]
T8579 6314-6315 . denotes .
T8580 6315-6459 sentence denotes The lowering of leptin levels in aged Sam68−/− mice is consistent with these mice having a high bone mass compared with their aged littermates.
T8581 6316-6319 DT denotes The
T8582 6320-6328 NN denotes lowering
T8584 6329-6331 IN denotes of
T8585 6332-6338 NN denotes leptin
T8586 6339-6345 NNS denotes levels
T8587 6346-6348 IN denotes in
T8588 6349-6353 JJ denotes aged
T8590 6354-6359 NN denotes Sam68
T8591 6359-6360 SYM denotes −
T8592 6360-6361 HYPH denotes /
T8593 6361-6362 SYM denotes −
T8589 6363-6367 NNS denotes mice
T8583 6368-6370 VBZ denotes is
T8594 6371-6381 JJ denotes consistent
T8595 6382-6386 IN denotes with
T8596 6387-6392 DT denotes these
T8597 6393-6397 NNS denotes mice
T8598 6398-6404 VBG denotes having
T8599 6405-6406 DT denotes a
T8601 6407-6411 JJ denotes high
T8602 6412-6416 NN denotes bone
T8600 6417-6421 NN denotes mass
T8603 6422-6430 VBN denotes compared
T8604 6431-6435 IN denotes with
T8605 6436-6441 PRP$ denotes their
T8607 6442-6446 JJ denotes aged
T8606 6447-6458 NNS denotes littermates
T8608 6458-6459 . denotes .
T8609 6459-6649 sentence denotes These data would suggest that the leptin-sympathetic pathway is unaltered in Sam68−/− mice and that the lowering of leptin may explain the lower levels of CTX in the serum of Sam68−/− mice.
T8610 6460-6465 DT denotes These
T8611 6466-6470 NNS denotes data
T8613 6471-6476 MD denotes would
T8612 6477-6484 VB denotes suggest
T8614 6485-6489 IN denotes that
T8616 6490-6493 DT denotes the
T8618 6494-6500 NN denotes leptin
T8620 6500-6501 HYPH denotes -
T8619 6501-6512 JJ denotes sympathetic
T8617 6513-6520 NN denotes pathway
T8615 6521-6523 VBZ denotes is
T8621 6524-6533 JJ denotes unaltered
T8622 6534-6536 IN denotes in
T8623 6537-6542 NN denotes Sam68
T8625 6542-6543 SYM denotes −
T8626 6543-6544 HYPH denotes /
T8627 6544-6545 SYM denotes −
T8624 6546-6550 NNS denotes mice
T8628 6551-6554 CC denotes and
T8629 6555-6559 IN denotes that
T8631 6560-6563 DT denotes the
T8632 6564-6572 NN denotes lowering
T8633 6573-6575 IN denotes of
T8634 6576-6582 NN denotes leptin
T8635 6583-6586 MD denotes may
T8630 6587-6594 VB denotes explain
T8636 6595-6598 DT denotes the
T8638 6599-6604 JJR denotes lower
T8637 6605-6611 NNS denotes levels
T8639 6612-6614 IN denotes of
T8640 6615-6618 NN denotes CTX
T8641 6619-6621 IN denotes in
T8642 6622-6625 DT denotes the
T8643 6626-6631 NN denotes serum
T8644 6632-6634 IN denotes of
T8645 6635-6640 NN denotes Sam68
T8647 6640-6641 SYM denotes −
T8648 6641-6642 HYPH denotes /
T8649 6642-6643 SYM denotes −
T8646 6644-6648 NNS denotes mice
T8650 6648-6649 . denotes .
T8651 6649-6953 sentence denotes These findings suggest that Sam68 may be regulating bone metabolism at two different levels: (1) the absence of Sam68 results in lower leptin levels that may reduce bone resorption via the sympathetic nervous system and (2) the absence of Sam68 favors osteoblast, rather than adipocyte, differentiation.
T8652 6650-6655 DT denotes These
T8653 6656-6664 NNS denotes findings
T8654 6665-6672 VBP denotes suggest
T8656 6673-6677 IN denotes that
T8658 6678-6683 NN denotes Sam68
T8659 6684-6687 MD denotes may
T8660 6688-6690 VB denotes be
T8657 6691-6701 VBG denotes regulating
T8661 6702-6706 NN denotes bone
T8662 6707-6717 NN denotes metabolism
T8663 6718-6720 IN denotes at
T8664 6721-6724 CD denotes two
T8666 6725-6734 JJ denotes different
T8665 6735-6741 NNS denotes levels
T8667 6741-6743 : denotes :
T8668 6743-6744 -LRB- denotes (
T8669 6744-6745 LS denotes 1
T8670 6745-6746 -RRB- denotes )
T8671 6747-6750 DT denotes the
T8672 6751-6758 NN denotes absence
T8673 6759-6761 IN denotes of
T8674 6762-6767 NN denotes Sam68
T8655 6768-6775 VBZ denotes results
T8675 6776-6778 IN denotes in
T8676 6779-6784 JJR denotes lower
T8678 6785-6791 NN denotes leptin
T8677 6792-6798 NNS denotes levels
T8679 6799-6803 WDT denotes that
T8681 6804-6807 MD denotes may
T8680 6808-6814 VB denotes reduce
T8682 6815-6819 NN denotes bone
T8683 6820-6830 NN denotes resorption
T8684 6831-6834 IN denotes via
T8685 6835-6838 DT denotes the
T8687 6839-6850 JJ denotes sympathetic
T8688 6851-6858 JJ denotes nervous
T8686 6859-6865 NN denotes system
T8689 6866-6869 CC denotes and
T8690 6870-6871 -LRB- denotes (
T8691 6871-6872 LS denotes 2
T8693 6872-6873 -RRB- denotes )
T8694 6874-6877 DT denotes the
T8695 6878-6885 NN denotes absence
T8696 6886-6888 IN denotes of
T8697 6889-6894 NN denotes Sam68
T8692 6895-6901 VBZ denotes favors
T8698 6902-6912 NN denotes osteoblast
T8700 6912-6914 , denotes ,
T8701 6914-6920 RB denotes rather
T8702 6921-6925 IN denotes than
T8703 6926-6935 NN denotes adipocyte
T8704 6935-6937 , denotes ,
T8699 6937-6952 NN denotes differentiation
T8705 6952-6953 . denotes .
T8706 6953-7087 sentence denotes In conclusion, our data define a physiologic role for Sam68 in bone metabolism and bone marrow mesenchymal stem cell differentiation.
T8707 6954-6956 IN denotes In
T8709 6957-6967 NN denotes conclusion
T8710 6967-6969 , denotes ,
T8711 6969-6972 PRP$ denotes our
T8712 6973-6977 NNS denotes data
T8708 6978-6984 VBP denotes define
T8713 6985-6986 DT denotes a
T8715 6987-6998 JJ denotes physiologic
T8714 6999-7003 NN denotes role
T8716 7004-7007 IN denotes for
T8717 7008-7013 NN denotes Sam68
T8718 7014-7016 IN denotes in
T8719 7017-7021 NN denotes bone
T8720 7022-7032 NN denotes metabolism
T8721 7033-7036 CC denotes and
T8722 7037-7041 NN denotes bone
T8723 7042-7048 NN denotes marrow
T8725 7049-7060 JJ denotes mesenchymal
T8727 7061-7065 NN denotes stem
T8726 7066-7070 NN denotes cell
T8724 7071-7086 NN denotes differentiation
T8728 7086-7087 . denotes .
T8729 7087-7200 sentence denotes The bone phenotype observed in Sam68−/− mice imply that inhibitors of Sam68 could prevent age-related bone loss.
T8730 7088-7091 DT denotes The
T8732 7092-7096 NN denotes bone
T8731 7097-7106 NN denotes phenotype
T8734 7107-7115 VBN denotes observed
T8735 7116-7118 IN denotes in
T8736 7119-7124 NN denotes Sam68
T8738 7124-7125 SYM denotes −
T8739 7125-7126 HYPH denotes /
T8740 7126-7127 SYM denotes −
T8737 7128-7132 NNS denotes mice
T8733 7133-7138 VBP denotes imply
T8741 7139-7143 IN denotes that
T8743 7144-7154 NNS denotes inhibitors
T8744 7155-7157 IN denotes of
T8745 7158-7163 NN denotes Sam68
T8746 7164-7169 MD denotes could
T8742 7170-7177 VB denotes prevent
T8747 7178-7181 NN denotes age
T8749 7181-7182 HYPH denotes -
T8748 7182-7189 VBN denotes related
T8751 7190-7194 NN denotes bone
T8750 7195-7199 NN denotes loss
T8752 7199-7200 . denotes .
T8753 7200-7386 sentence denotes Furthermore, the results also suggest that Sam68 expression levels, hypomorphism, and mutations in humans may influence susceptibility to marrow adipocyte accumulation and osteoporosis.
T8754 7201-7212 RB denotes Furthermore
T8756 7212-7214 , denotes ,
T8757 7214-7217 DT denotes the
T8758 7218-7225 NNS denotes results
T8759 7226-7230 RB denotes also
T8755 7231-7238 VBP denotes suggest
T8760 7239-7243 IN denotes that
T8762 7244-7249 NN denotes Sam68
T8764 7250-7260 NN denotes expression
T8763 7261-7267 NNS denotes levels
T8765 7267-7269 , denotes ,
T8766 7269-7281 NN denotes hypomorphism
T8767 7281-7283 , denotes ,
T8768 7283-7286 CC denotes and
T8769 7287-7296 NNS denotes mutations
T8770 7297-7299 IN denotes in
T8771 7300-7306 NNS denotes humans
T8772 7307-7310 MD denotes may
T8761 7311-7320 VB denotes influence
T8773 7321-7335 NN denotes susceptibility
T8774 7336-7338 IN denotes to
T8775 7339-7345 NN denotes marrow
T8776 7346-7355 NN denotes adipocyte
T8777 7356-7368 NN denotes accumulation
T8778 7369-7372 CC denotes and
T8779 7373-7385 NN denotes osteoporosis
T8780 7385-7386 . denotes .
T8781 7386-7458 sentence denotes Our findings also identify a new animal model to study aging bone loss.
T8782 7387-7390 PRP$ denotes Our
T8783 7391-7399 NNS denotes findings
T8785 7400-7404 RB denotes also
T8784 7405-7413 VBP denotes identify
T8786 7414-7415 DT denotes a
T8788 7416-7419 JJ denotes new
T8789 7420-7426 NN denotes animal
T8787 7427-7432 NN denotes model
T8790 7433-7435 TO denotes to
T8791 7436-7441 VB denotes study
T8792 7442-7447 VBG denotes aging
T8794 7448-7452 NN denotes bone
T8793 7453-7457 NN denotes loss
T8795 7457-7458 . denotes .
R4104 T7333 T7334 det The,study
R4105 T7334 T7336 nsubj study,provides
R4106 T7335 T7334 amod present,study
R4107 T7337 T7336 dobj evidence,provides
R4108 T7338 T7339 mark that,is
R4109 T7339 T7337 acl is,evidence
R4110 T7340 T7341 det a,role
R4111 T7341 T7339 nsubj role,is
R4112 T7342 T7341 amod physiologic,role
R4113 T7343 T7341 prep of,role
R4114 T7344 T7343 pobj Sam68,of
R4115 T7345 T7346 aux to,modulate
R4116 T7346 T7339 xcomp modulate,is
R4117 T7347 T7348 nmod bone,marrow
R4118 T7348 T7349 nmod marrow,cells
R4119 T7349 T7346 dobj cells,modulate
R4120 T7350 T7349 amod mesenchymal,cells
R4121 T7351 T7349 compound stem,cells
R4122 T7352 T7336 punct .,provides
R4123 T7354 T7355 amod Young,mice
R4124 T7355 T7360 nsubj mice,developed
R4125 T7356 T7355 nmod Sam68,mice
R4126 T7357 T7356 punct −,Sam68
R4127 T7358 T7356 punct /,Sam68
R4128 T7359 T7356 punct −,Sam68
R4129 T7361 T7360 advmod normally,developed
R4130 T7362 T7360 cc and,developed
R4131 T7363 T7360 conj contained,developed
R4132 T7364 T7365 amod similar,mass
R4133 T7365 T7363 dobj mass,contained
R4134 T7366 T7365 compound bone,mass
R4135 T7367 T7363 prep compared,contained
R4136 T7368 T7367 prep with,compared
R4137 T7369 T7370 amod wild,type
R4138 T7370 T7372 compound type,littermates
R4139 T7371 T7370 punct -,type
R4140 T7372 T7368 pobj littermates,with
R4141 T7373 T7360 punct .,developed
R4142 T7375 T7376 amod Aged,mice
R4143 T7376 T7385 nsubj mice,displayed
R4144 T7377 T7378 punct (,months
R4145 T7378 T7375 parataxis months,Aged
R4146 T7379 T7378 nummod 12,months
R4147 T7380 T7378 punct ),months
R4148 T7381 T7376 nmod Sam68,mice
R4149 T7382 T7381 punct −,Sam68
R4150 T7383 T7381 punct /,Sam68
R4151 T7384 T7381 punct −,Sam68
R4152 T7386 T7387 det a,phenotype
R4153 T7387 T7385 dobj phenotype,displayed
R4154 T7388 T7389 amod high,mass
R4155 T7389 T7387 compound mass,phenotype
R4156 T7390 T7389 compound bone,mass
R4157 T7391 T7385 prep compared,displayed
R4158 T7392 T7391 prep with,compared
R4159 T7393 T7394 nmod Sam68,littermates
R4160 T7394 T7392 pobj littermates,with
R4161 T7395 T7393 punct +,Sam68
R4162 T7396 T7393 punct /,Sam68
R4163 T7397 T7393 punct +,Sam68
R4164 T7398 T7385 punct .,displayed
R4165 T7400 T7401 det The,littermates
R4166 T7401 T7405 nsubj littermates,underwent
R4167 T7402 T7403 amod wild,type
R4168 T7403 T7401 compound type,littermates
R4169 T7404 T7403 punct -,type
R4170 T7406 T7407 npadvmod age,related
R4171 T7407 T7409 amod related,loss
R4172 T7408 T7407 punct -,related
R4173 T7409 T7405 dobj loss,underwent
R4174 T7410 T7409 compound bone,loss
R4175 T7411 T7412 dep that,occurs
R4176 T7412 T7409 relcl occurs,loss
R4177 T7413 T7412 advmod naturally,occurs
R4178 T7414 T7412 prep in,occurs
R4179 T7415 T7414 pobj mammals,in
R4180 T7416 T7405 punct ", ",underwent
R4181 T7417 T7418 mark while,preserved
R4182 T7418 T7405 advcl preserved,underwent
R4183 T7419 T7420 det the,animals
R4184 T7420 T7418 nsubj animals,preserved
R4185 T7421 T7420 nmod Sam68,animals
R4186 T7422 T7421 punct −,Sam68
R4187 T7423 T7421 punct /,Sam68
R4188 T7424 T7421 punct −,Sam68
R4189 T7425 T7426 poss their,mass
R4190 T7426 T7418 dobj mass,preserved
R4191 T7427 T7426 compound bone,mass
R4192 T7428 T7418 prep with,preserved
R4193 T7429 T7428 pobj aging,with
R4194 T7430 T7405 punct .,underwent
R4195 T7432 T7433 det The,differentiation
R4196 T7433 T7434 nsubj differentiation,resulted
R4197 T7435 T7433 prep of,differentiation
R4198 T7436 T7437 compound bone,marrow
R4199 T7437 T7438 compound marrow,cells
R4200 T7438 T7435 pobj cells,of
R4201 T7439 T7438 compound stem,cells
R4202 T7440 T7438 acl isolated,cells
R4203 T7441 T7440 prep from,isolated
R4204 T7442 T7443 nmod Sam68,mice
R4205 T7443 T7441 pobj mice,from
R4206 T7444 T7442 punct −,Sam68
R4207 T7445 T7442 punct /,Sam68
R4208 T7446 T7442 punct −,Sam68
R4209 T7447 T7438 cc and,cells
R4210 T7448 T7449 amod embryonic,cells
R4211 T7449 T7438 conj cells,cells
R4212 T7450 T7449 amod mesenchymal,cells
R4213 T7451 T7449 amod multipotential,cells
R4214 T7452 T7449 compound progenitor,cells
R4215 T7453 T7449 appos C3H10T1,cells
R4216 T7454 T7453 punct /,C3H10T1
R4217 T7455 T7453 nummod 2,C3H10T1
R4218 T7456 T7449 acl treated,cells
R4219 T7457 T7456 prep with,treated
R4220 T7458 T7459 compound Sam68,shRNA
R4221 T7459 T7457 pobj shRNA,with
R4222 T7460 T7434 prep in,resulted
R4223 T7461 T7462 det a,differentiation
R4224 T7462 T7460 pobj differentiation,in
R4225 T7463 T7464 advmod more,pronounced
R4226 T7464 T7462 amod pronounced,differentiation
R4227 T7465 T7462 compound osteoblast,differentiation
R4228 T7466 T7434 punct .,resulted
R4229 T7468 T7469 det These,findings
R4230 T7469 T7470 nsubj findings,demonstrate
R4231 T7471 T7472 mark that,enhances
R4232 T7472 T7470 ccomp enhances,demonstrate
R4233 T7473 T7474 det the,loss
R4234 T7474 T7472 nsubj loss,enhances
R4235 T7475 T7474 prep of,loss
R4236 T7476 T7475 pobj Sam68,of
R4237 T7477 T7478 compound osteoblast,differentiation
R4238 T7478 T7472 dobj differentiation,enhances
R4239 T7479 T7470 punct .,demonstrate
R4240 T7481 T7482 det The,converse
R4241 T7482 T7483 nsubj converse,was
R4242 T7484 T7483 advmod also,was
R4243 T7485 T7483 acomp true,was
R4244 T7486 T7483 punct ", ",was
R4245 T7487 T7488 mark as,impaired
R4246 T7488 T7483 advcl impaired,was
R4247 T7489 T7488 nsubjpass MEFs,impaired
R4248 T7490 T7489 acl isolated,MEFs
R4249 T7491 T7490 prep from,isolated
R4250 T7492 T7493 nmod Sam68,animals
R4251 T7493 T7491 pobj animals,from
R4252 T7494 T7492 punct −,Sam68
R4253 T7495 T7492 punct /,Sam68
R4254 T7496 T7492 punct −,Sam68
R4255 T7497 T7488 auxpass were,impaired
R4256 T7498 T7488 prep in,impaired
R4257 T7499 T7500 poss their,ability
R4258 T7500 T7498 pobj ability,in
R4259 T7501 T7502 aux to,undergo
R4260 T7502 T7500 acl undergo,ability
R4261 T7503 T7504 compound adipocyte,differentiation
R4262 T7504 T7502 dobj differentiation,undergo
R4263 T7505 T7488 prep compared,impaired
R4264 T7506 T7505 prep with,compared
R4265 T7507 T7508 nmod Sam68,MEFs
R4266 T7508 T7506 pobj MEFs,with
R4267 T7509 T7507 punct +,Sam68
R4268 T7510 T7507 punct /,Sam68
R4269 T7511 T7507 punct +,Sam68
R4270 T7512 T7483 punct .,was
R4271 T7514 T7515 det These,findings
R4272 T7515 T7516 nsubj findings,suggest
R4273 T7517 T7518 mark that,is
R4274 T7518 T7516 ccomp is,suggest
R4275 T7519 T7520 det a,role
R4276 T7520 T7518 nsubj role,is
R4277 T7521 T7520 amod physiologic,role
R4278 T7522 T7520 prep for,role
R4279 T7523 T7522 pobj Sam68,for
R4280 T7524 T7525 aux to,regulate
R4281 T7525 T7518 xcomp regulate,is
R4282 T7526 T7527 det the,balance
R4283 T7527 T7525 dobj balance,regulate
R4284 T7528 T7527 prep between,balance
R4285 T7529 T7530 amod adipogenic,differentiation
R4286 T7530 T7528 pobj differentiation,between
R4287 T7531 T7529 cc and,adipogenic
R4288 T7532 T7529 conj osteogenic,adipogenic
R4289 T7533 T7530 prep of,differentiation
R4290 T7534 T7535 det the,marrow
R4291 T7535 T7533 pobj marrow,of
R4292 T7536 T7535 compound bone,marrow
R4293 T7537 T7535 amod mesenchymal,marrow
R4294 T7538 T7516 punct .,suggest
R4295 T7540 T7541 compound Sam68,expression
R4296 T7541 T7543 nsubjpass expression,observed
R4297 T7542 T7541 compound protein,expression
R4298 T7544 T7543 auxpass was,observed
R4299 T7545 T7543 prep throughout,observed
R4300 T7546 T7547 det the,embryo
R4301 T7547 T7545 pobj embryo,throughout
R4302 T7548 T7547 amod developing,embryo
R4303 T7549 T7547 compound mouse,embryo
R4304 T7550 T7543 punct ", ",observed
R4305 T7551 T7543 prep in,observed
R4306 T7552 T7551 pobj keeping,in
R4307 T7553 T7552 prep with,keeping
R4308 T7554 T7555 amod previous,reports
R4309 T7555 T7553 pobj reports,with
R4310 T7556 T7557 dep that,identified
R4311 T7557 T7555 relcl identified,reports
R4312 T7558 T7559 det the,mRNA
R4313 T7559 T7561 nsubjpass mRNA,expressed
R4314 T7560 T7559 compound Sam68,mRNA
R4315 T7561 T7557 ccomp expressed,identified
R4316 T7562 T7561 aux to,expressed
R4317 T7563 T7561 auxpass be,expressed
R4318 T7564 T7561 advmod widely,expressed
R4319 T7565 T7566 punct [,38
R4320 T7566 T7543 parataxis 38,observed
R4321 T7567 T7566 punct ],38
R4322 T7568 T7543 punct .,observed
R4323 T7570 T7571 nsubj We,observe
R4324 T7572 T7573 compound Sam68,staining
R4325 T7573 T7571 dobj staining,observe
R4326 T7574 T7571 prep in,observe
R4327 T7575 T7576 det the,brain
R4328 T7576 T7574 pobj brain,in
R4329 T7577 T7576 punct ", ",brain
R4330 T7578 T7576 conj heart,brain
R4331 T7579 T7578 punct ", ",heart
R4332 T7580 T7578 cc and,heart
R4333 T7581 T7578 conj intestine,heart
R4334 T7582 T7583 punct (,see
R4335 T7583 T7581 parataxis see,intestine
R4336 T7584 T7583 dobj Figure,see
R4337 T7585 T7584 nummod 1,Figure
R4338 T7586 T7583 punct ),see
R4339 T7587 T7588 advmod as,as
R4340 T7588 T7576 cc as,brain
R4341 T7589 T7588 advmod well,as
R4342 T7590 T7576 conj liver,brain
R4343 T7591 T7590 punct ", ",liver
R4344 T7592 T7590 conj skin,liver
R4345 T7593 T7592 punct ", ",skin
R4346 T7594 T7592 cc and,skin
R4347 T7595 T7592 conj kidney,skin
R4348 T7596 T7597 punct (,data
R4349 T7597 T7595 meta data,kidney
R4350 T7598 T7597 amod unpublished,data
R4351 T7599 T7597 punct ),data
R4352 T7600 T7576 prep of,brain
R4353 T7601 T7602 amod late,stage
R4354 T7602 T7604 compound stage,embryos
R4355 T7603 T7602 punct -,stage
R4356 T7604 T7600 pobj embryos,of
R4357 T7605 T7571 punct .,observe
R4358 T7607 T7608 det This,pattern
R4359 T7608 T7610 nsubj pattern,is
R4360 T7609 T7608 compound expression,pattern
R4361 T7611 T7610 acomp consistent,is
R4362 T7612 T7611 prep with,consistent
R4363 T7613 T7614 amod previous,work
R4364 T7614 T7612 pobj work,with
R4365 T7615 T7616 dep that,observed
R4366 T7616 T7614 relcl observed,work
R4367 T7617 T7616 aux has,observed
R4368 T7618 T7616 dobj Sam68,observed
R4369 T7619 T7618 prep in,Sam68
R4370 T7620 T7619 pobj neurons,in
R4371 T7621 T7622 punct [,52
R4372 T7622 T7619 parataxis 52,in
R4373 T7623 T7622 punct ],52
R4374 T7624 T7619 cc and,in
R4375 T7625 T7619 conj as,in
R4376 T7626 T7627 det a,substrate
R4377 T7627 T7625 pobj substrate,as
R4378 T7628 T7627 prep of,substrate
R4379 T7629 T7630 det the,kinase
R4380 T7630 T7628 pobj kinase,of
R4381 T7631 T7632 amod intestinal,SIK
R4382 T7632 T7630 nmod SIK,kinase
R4383 T7633 T7632 punct /,SIK
R4384 T7634 T7635 compound breast,tumor
R4385 T7635 T7632 appos tumor,SIK
R4386 T7636 T7637 punct [,43
R4387 T7637 T7627 parataxis 43,substrate
R4388 T7638 T7637 punct ],43
R4389 T7639 T7610 punct .,is
R4390 T7641 T7642 det The,expression
R4391 T7642 T7643 nsubjpass expression,altered
R4392 T7644 T7642 prep of,expression
R4393 T7645 T7644 pobj Sam68,of
R4394 T7646 T7643 auxpass was,altered
R4395 T7647 T7643 neg not,altered
R4396 T7648 T7643 prep in,altered
R4397 T7649 T7650 amod aging,cells
R4398 T7650 T7648 pobj cells,in
R4399 T7651 T7652 nmod bone,marrow
R4400 T7652 T7650 nmod marrow,cells
R4401 T7653 T7650 amod stromal,cells
R4402 T7654 T7648 cc or,in
R4403 T7655 T7648 conj in,in
R4404 T7656 T7657 amod senescencing,cells
R4405 T7657 T7655 pobj cells,in
R4406 T7658 T7657 nmod WI,cells
R4407 T7659 T7658 punct -,WI
R4408 T7660 T7658 nummod 38,WI
R4409 T7661 T7662 punct (,data
R4410 T7662 T7643 meta data,altered
R4411 T7663 T7662 amod unpublished,data
R4412 T7664 T7662 punct ),data
R4413 T7665 T7643 punct .,altered
R4414 T7667 T7668 det The,presence
R4415 T7668 T7669 nsubj presence,predicted
R4416 T7670 T7668 prep of,presence
R4417 T7671 T7670 pobj Sam68,of
R4418 T7672 T7668 prep in,presence
R4419 T7673 T7672 pobj chondrocytes,in
R4420 T7674 T7673 punct ", ",chondrocytes
R4421 T7675 T7673 conj osteoblasts,chondrocytes
R4422 T7676 T7675 cc and,osteoblasts
R4423 T7677 T7675 conj osteoclasts,osteoblasts
R4424 T7678 T7673 prep in,chondrocytes
R4425 T7679 T7680 amod developing,cartilage
R4426 T7680 T7678 pobj cartilage,in
R4427 T7681 T7680 cc and,cartilage
R4428 T7682 T7680 conj bone,cartilage
R4429 T7683 T7684 det a,role
R4430 T7684 T7669 dobj role,predicted
R4431 T7685 T7684 amod pivotal,role
R4432 T7686 T7684 prep for,role
R4433 T7687 T7688 det the,protein
R4434 T7688 T7686 pobj protein,for
R4435 T7689 T7684 prep in,role
R4436 T7690 T7691 amod skeletal,development
R4437 T7691 T7689 pobj development,in
R4438 T7692 T7669 punct .,predicted
R4439 T7694 T7695 det The,mice
R4440 T7695 T7700 nsubjpass mice,generated
R4441 T7696 T7695 nmod Sam68,mice
R4442 T7697 T7696 punct −,Sam68
R4443 T7698 T7696 punct /,Sam68
R4444 T7699 T7696 punct −,Sam68
R4445 T7701 T7700 auxpass were,generated
R4446 T7702 T7700 advcl using,generated
R4447 T7703 T7704 det a,approach
R4448 T7704 T7702 dobj approach,using
R4449 T7705 T7704 amod traditional,approach
R4450 T7706 T7704 compound targeting,approach
R4451 T7707 T7708 advmod where,deleted
R4452 T7708 T7704 relcl deleted,approach
R4453 T7709 T7710 det the,domain
R4454 T7710 T7708 nsubjpass domain,deleted
R4455 T7711 T7710 amod functional,domain
R4456 T7712 T7710 compound KH,domain
R4457 T7713 T7708 auxpass was,deleted
R4458 T7714 T7700 cc and,generated
R4459 T7715 T7716 advmod approximately,one
R4460 T7716 T7717 nsubj one,survived
R4461 T7717 T7700 conj survived,generated
R4462 T7718 T7716 amod third,one
R4463 T7719 T7716 prep of,one
R4464 T7720 T7721 det the,mice
R4465 T7721 T7719 pobj mice,of
R4466 T7722 T7721 nmod Sam68,mice
R4467 T7723 T7722 punct −,Sam68
R4468 T7724 T7722 punct /,Sam68
R4469 T7725 T7722 punct −,Sam68
R4470 T7726 T7717 prep to,survived
R4471 T7727 T7726 pobj adulthood,to
R4472 T7728 T7717 prep with,survived
R4473 T7729 T7730 det no,defects
R4474 T7730 T7728 pobj defects,with
R4475 T7731 T7730 amod apparent,defects
R4476 T7732 T7717 punct .,survived
R4477 T7734 T7735 nummod One,explanation
R4478 T7735 T7736 nsubj explanation,is
R4479 T7737 T7735 prep for,explanation
R4480 T7738 T7739 det this,phenomenon
R4481 T7739 T7737 pobj phenomenon,for
R4482 T7740 T7741 mark that,sub-served
R4483 T7741 T7736 ccomp sub-served,is
R4484 T7742 T7743 compound Sam68,function
R4485 T7743 T7741 nsubjpass function,sub-served
R4486 T7744 T7741 auxpass is,sub-served
R4487 T7745 T7741 agent by,sub-served
R4488 T7746 T7745 pobj one,by
R4489 T7747 T7746 cc or,one
R4490 T7748 T7746 conj more,one
R4491 T7749 T7746 prep of,one
R4492 T7750 T7751 poss its,members
R4493 T7751 T7749 pobj members,of
R4494 T7752 T7751 compound family,members
R4495 T7753 T7741 prep during,sub-served
R4496 T7754 T7753 pobj development,during
R4497 T7755 T7756 amod such,as
R4498 T7756 T7741 prep as,sub-served
R4499 T7757 T7756 pobj SLM,as
R4500 T7758 T7757 punct -,SLM
R4501 T7759 T7757 nummod 1,SLM
R4502 T7760 T7757 cc and,SLM
R4503 T7761 T7757 conj SLM,SLM
R4504 T7762 T7761 punct -,SLM
R4505 T7763 T7761 nummod 2,SLM
R4506 T7764 T7765 punct [,47
R4507 T7765 T7736 parataxis 47,is
R4508 T7766 T7765 punct ],47
R4509 T7767 T7736 punct .,is
R4510 T7769 T7770 advmod Alternatively,required
R4511 T7771 T7770 punct ", ",required
R4512 T7772 T7770 nsubjpass Sam68,required
R4513 T7773 T7770 auxpass is,required
R4514 T7774 T7770 neg not,required
R4515 T7775 T7770 prep during,required
R4516 T7776 T7777 amod embryonic,development
R4517 T7777 T7775 pobj development,during
R4518 T7778 T7770 punct .,required
R4519 T7780 T7781 advmod However,killed
R4520 T7782 T7781 punct ", ",killed
R4521 T7783 T7784 nummod two,thirds
R4522 T7784 T7781 nsubjpass thirds,killed
R4523 T7785 T7784 prep of,thirds
R4524 T7786 T7787 det the,Sam68
R4525 T7787 T7785 pobj Sam68,of
R4526 T7788 T7787 punct −,Sam68
R4527 T7789 T7787 punct /,Sam68
R4528 T7790 T7787 punct −,Sam68
R4529 T7791 T7787 punct ", ",Sam68
R4530 T7792 T7787 cc but,Sam68
R4531 T7793 T7792 neg not,but
R4532 T7794 T7795 det the,Sam68
R4533 T7795 T7796 nmod Sam68,pups
R4534 T7796 T7787 conj pups,Sam68
R4535 T7797 T7795 punct +,Sam68
R4536 T7798 T7795 punct /,Sam68
R4537 T7799 T7795 punct -,Sam68
R4538 T7800 T7781 punct ", ",killed
R4539 T7801 T7781 auxpass were,killed
R4540 T7802 T7781 agent by,killed
R4541 T7803 T7804 poss their,mothers
R4542 T7804 T7802 pobj mothers,by
R4543 T7805 T7804 nmod Sam68,mothers
R4544 T7806 T7805 punct +,Sam68
R4545 T7807 T7805 punct /,Sam68
R4546 T7808 T7805 punct -,Sam68
R4547 T7809 T7781 punct .,killed
R4548 T7811 T7812 det These,findings
R4549 T7812 T7813 nsubj findings,suggest
R4550 T7814 T7815 mark that,are
R4551 T7815 T7813 ccomp are,suggest
R4552 T7816 T7817 det the,mothers
R4553 T7817 T7815 nsubj mothers,are
R4554 T7818 T7815 acomp able,are
R4555 T7819 T7820 aux to,detect
R4556 T7820 T7818 xcomp detect,able
R4557 T7821 T7822 det a,difference
R4558 T7822 T7820 dobj difference,detect
R4559 T7823 T7822 amod subtle,difference
R4560 T7824 T7822 compound defect,difference
R4561 T7825 T7822 punct /,difference
R4562 T7826 T7827 dep that,can
R4563 T7827 T7822 relcl can,difference
R4564 T7828 T7827 nsubj we,can
R4565 T7829 T7827 neg not,can
R4566 T7830 T7813 punct .,suggest
R4567 T7832 T7833 amod Adult,mice
R4568 T7833 T7838 nsubj mice,live
R4569 T7834 T7833 nmod Sam68,mice
R4570 T7835 T7834 punct −,Sam68
R4571 T7836 T7834 punct /,Sam68
R4572 T7837 T7834 punct −,Sam68
R4573 T7839 T7840 det a,span
R4574 T7840 T7838 dobj span,live
R4575 T7841 T7840 amod normal,span
R4576 T7842 T7840 compound life,span
R4577 T7843 T7840 prep of,span
R4578 T7844 T7845 advmod approximately,two
R4579 T7845 T7846 nummod two,years
R4580 T7846 T7843 pobj years,of
R4581 T7847 T7838 punct .,live
R4582 T7849 T7850 det The,males
R4583 T7850 T7855 nsubj males,were
R4584 T7851 T7850 nmod Sam68,males
R4585 T7852 T7851 punct −,Sam68
R4586 T7853 T7851 punct /,Sam68
R4587 T7854 T7851 punct −,Sam68
R4588 T7856 T7855 acomp sterile,were
R4589 T7857 T7855 cc and,were
R4590 T7858 T7859 det the,females
R4591 T7859 T7864 nsubj females,provided
R4592 T7860 T7859 nmod Sam68,females
R4593 T7861 T7860 punct −,Sam68
R4594 T7862 T7860 punct /,Sam68
R4595 T7863 T7860 punct −,Sam68
R4596 T7864 T7855 conj provided,were
R4597 T7865 T7866 amod inadequate,care
R4598 T7866 T7864 dobj care,provided
R4599 T7867 T7864 dative to,provided
R4600 T7868 T7869 poss their,young
R4601 T7869 T7867 pobj young,to
R4602 T7870 T7855 punct ", ",were
R4603 T7871 T7855 cc but,were
R4604 T7872 T7873 det the,pups
R4605 T7873 T7874 nsubjpass pups,scattered
R4606 T7874 T7855 conj scattered,were
R4607 T7875 T7874 auxpass were,scattered
R4608 T7876 T7874 neg not,scattered
R4609 T7877 T7874 cc and,scattered
R4610 T7878 T7874 conj neglected,scattered
R4611 T7879 T7880 mark as,observed
R4612 T7880 T7878 advcl observed,neglected
R4613 T7881 T7880 prep with,observed
R4614 T7882 T7883 nmod FosB,mice
R4615 T7883 T7881 pobj mice,with
R4616 T7884 T7882 punct −,FosB
R4617 T7885 T7882 punct /,FosB
R4618 T7886 T7882 punct −,FosB
R4619 T7887 T7888 punct [,53
R4620 T7888 T7878 parataxis 53,neglected
R4621 T7889 T7888 punct ],53
R4622 T7890 T7874 punct .,scattered
R4623 T7892 T7893 compound Serum,levels
R4624 T7893 T7894 nsubj levels,decreased
R4625 T7894 T7897 ccomp decreased,decreased
R4626 T7895 T7893 prep of,levels
R4627 T7896 T7895 pobj estrogen,of
R4628 T7898 T7894 prep in,decreased
R4629 T7899 T7900 amod aging,females
R4630 T7900 T7898 pobj females,in
R4631 T7901 T7900 nmod Sam68,females
R4632 T7902 T7901 punct −,Sam68
R4633 T7903 T7901 punct /,Sam68
R4634 T7904 T7901 punct −,Sam68
R4635 T7905 T7906 mark as,expected
R4636 T7906 T7894 advcl expected,decreased
R4637 T7907 T7897 punct ;,decreased
R4638 T7908 T7897 advmod however,decreased
R4639 T7909 T7897 punct ", ",decreased
R4640 T7910 T7911 det the,levels
R4641 T7911 T7897 nsubj levels,decreased
R4642 T7912 T7911 compound leptin,levels
R4643 T7913 T7897 prep in,decreased
R4644 T7914 T7915 amod aged,females
R4645 T7915 T7913 pobj females,in
R4646 T7916 T7915 nmod Sam68,females
R4647 T7917 T7916 punct −,Sam68
R4648 T7918 T7916 punct /,Sam68
R4649 T7919 T7916 punct −,Sam68
R4650 T7920 T7897 punct .,decreased
R4651 T7922 T7923 det The,females
R4652 T7923 T7929 nsubj females,were
R4653 T7924 T7923 amod aged,females
R4654 T7925 T7923 nmod Sam68,females
R4655 T7926 T7925 punct −,Sam68
R4656 T7927 T7925 punct /,Sam68
R4657 T7928 T7925 punct −,Sam68
R4658 T7930 T7929 neg not,were
R4659 T7931 T7929 acomp obese,were
R4660 T7932 T7929 cc and,were
R4661 T7933 T7934 advmod actually,weighed
R4662 T7934 T7929 conj weighed,were
R4663 T7935 T7934 dobj less,weighed
R4664 T7936 T7935 prep than,less
R4665 T7937 T7938 det the,controls
R4666 T7938 T7936 pobj controls,than
R4667 T7939 T7938 compound littermate,controls
R4668 T7940 T7941 punct (,see
R4669 T7941 T7934 parataxis see,weighed
R4670 T7942 T7941 dobj Table,see
R4671 T7943 T7942 nummod 2,Table
R4672 T7944 T7941 punct ),see
R4673 T7945 T7929 punct .,were
R4674 T7947 T7948 advmod Moreover,altered
R4675 T7949 T7948 punct ", ",altered
R4676 T7950 T7951 poss their,appetite
R4677 T7951 T7948 nsubjpass appetite,altered
R4678 T7952 T7948 auxpass was,altered
R4679 T7953 T7948 neg not,altered
R4680 T7954 T7948 prep with,altered
R4681 T7955 T7954 pobj aging,with
R4682 T7956 T7957 punct (,N.
R4683 T7957 T7948 meta N.,altered
R4684 T7958 T7957 nmod Torabi,N.
R4685 T7959 T7957 cc and,N.
R4686 T7960 T7957 conj S.,N.
R4687 T7961 T7960 nmod Richard,S.
R4688 T7962 T7960 punct ", ",S.
R4689 T7963 T7964 amod unpublished,data
R4690 T7964 T7960 conj data,S.
R4691 T7965 T7964 punct ),data
R4692 T7966 T7948 punct ", ",altered
R4693 T7967 T7948 advcl suggesting,altered
R4694 T7968 T7969 mark that,recreating
R4695 T7969 T7967 ccomp recreating,suggesting
R4696 T7970 T7971 det the,reduction
R4697 T7971 T7969 nsubj reduction,recreating
R4698 T7972 T7971 amod observed,reduction
R4699 T7973 T7971 compound leptin,reduction
R4700 T7974 T7969 aux was,recreating
R4701 T7975 T7969 neg not,recreating
R4702 T7976 T7977 dep ob,like
R4703 T7977 T7981 amod like,phenotypes
R4704 T7978 T7977 punct /,like
R4705 T7979 T7977 npadvmod ob,like
R4706 T7980 T7977 punct -,like
R4707 T7981 T7969 dobj phenotypes,recreating
R4708 T7982 T7981 acl related,phenotypes
R4709 T7983 T7982 prep to,related
R4710 T7984 T7983 pobj weight,to
R4711 T7985 T7984 punct ", ",weight
R4712 T7986 T7984 conj appetite,weight
R4713 T7987 T7986 cc and,appetite
R4714 T7988 T7989 amod female,sterility
R4715 T7989 T7986 conj sterility,appetite
R4716 T7990 T7991 punct [,54
R4717 T7991 T7948 parataxis 54,altered
R4718 T7992 T7991 punct ],54
R4719 T7993 T7948 punct .,altered
R4720 T7995 T7996 det The,phenotyping
R4721 T7996 T7998 nsubj phenotyping,showed
R4722 T7997 T7996 amod skeletal,phenotyping
R4723 T7999 T7996 prep of,phenotyping
R4724 T8000 T7999 pobj cohorts,of
R4725 T8001 T8000 prep of,cohorts
R4726 T8002 T8003 nmod Sam68,mice
R4727 T8003 T8001 pobj mice,of
R4728 T8004 T8002 punct +,Sam68
R4729 T8005 T8002 punct /,Sam68
R4730 T8006 T8002 punct +,Sam68
R4731 T8007 T8002 cc and,Sam68
R4732 T8008 T8002 conj Sam68,Sam68
R4733 T8009 T8008 punct −,Sam68
R4734 T8010 T8008 punct /,Sam68
R4735 T8011 T8008 punct −,Sam68
R4736 T8012 T8013 mark that,preserved
R4737 T8013 T7998 ccomp preserved,showed
R4738 T8014 T8015 compound bone,mass
R4739 T8015 T8013 nsubjpass mass,preserved
R4740 T8016 T8013 auxpass was,preserved
R4741 T8017 T8013 prep in,preserved
R4742 T8018 T8019 amod aged,mice
R4743 T8019 T8017 pobj mice,in
R4744 T8020 T8019 nmod Sam68,mice
R4745 T8021 T8020 punct −,Sam68
R4746 T8022 T8020 punct /,Sam68
R4747 T8023 T8020 punct −,Sam68
R4748 T8024 T7998 punct .,showed
R4749 T8026 T8027 amod Traditional,histology
R4750 T8027 T8028 nsubj histology,suggested
R4751 T8029 T8027 cc and,histology
R4752 T8030 T8027 conj histomorphometry,histology
R4753 T8031 T8032 mark that,involved
R4754 T8032 T8028 ccomp involved,suggested
R4755 T8033 T8034 det the,mechanism
R4756 T8034 T8032 nsubj mechanism,involved
R4757 T8035 T8032 dobj preservation,involved
R4758 T8036 T8035 prep of,preservation
R4759 T8037 T8038 nmod osteoblast,activity
R4760 T8038 T8036 pobj activity,of
R4761 T8039 T8037 cc and,osteoblast
R4762 T8040 T8037 conj osteoclast,osteoblast
R4763 T8041 T8028 dep .,suggested
R4764 T8043 T8044 det The,role
R4765 T8044 T8046 nsubj role,led
R4766 T8045 T8044 amod documented,role
R4767 T8047 T8044 prep of,role
R4768 T8048 T8049 det the,protein
R4769 T8049 T8047 pobj protein,of
R4770 T8050 T8049 nmod Sam68,protein
R4771 T8051 T8049 amod regulatory,protein
R4772 T8052 T8049 punct ", ",protein
R4773 T8053 T8049 appos Src,protein
R4774 T8054 T8044 punct ", ",role
R4775 T8055 T8044 prep in,role
R4776 T8056 T8055 pobj osteopetrosis,in
R4777 T8057 T8046 dobj us,led
R4778 T8058 T8059 aux to,investigate
R4779 T8059 T8046 xcomp investigate,led
R4780 T8060 T8061 det the,morphology
R4781 T8061 T8059 dobj morphology,investigate
R4782 T8062 T8061 cc and,morphology
R4783 T8063 T8061 conj activity,morphology
R4784 T8064 T8061 prep of,morphology
R4785 T8065 T8066 nmod Sam68,osteoclasts
R4786 T8066 T8064 pobj osteoclasts,of
R4787 T8067 T8065 punct −,Sam68
R4788 T8068 T8065 punct /,Sam68
R4789 T8069 T8065 punct −,Sam68
R4790 T8070 T8071 advmod ex,vivo
R4791 T8071 T8059 advmod vivo,investigate
R4792 T8072 T8046 punct .,led
R4793 T8074 T8075 det The,kinase
R4794 T8075 T8078 nsubjpass kinase,shown
R4795 T8076 T8075 compound Src,kinase
R4796 T8077 T8075 compound tyrosine,kinase
R4797 T8079 T8078 auxpass was,shown
R4798 T8080 T8081 aux to,play
R4799 T8081 T8078 xcomp play,shown
R4800 T8082 T8083 det a,role
R4801 T8083 T8081 dobj role,play
R4802 T8084 T8081 prep in,play
R4803 T8085 T8086 compound bone,remodeling
R4804 T8086 T8084 pobj remodeling,in
R4805 T8087 T8088 advmod when,died
R4806 T8088 T8081 advcl died,play
R4807 T8089 T8090 nmod Src,mice
R4808 T8090 T8088 nsubj mice,died
R4809 T8091 T8089 punct −,Src
R4810 T8092 T8089 punct /,Src
R4811 T8093 T8089 punct −,Src
R4812 T8094 T8088 prep at,died
R4813 T8095 T8096 nummod 6,months
R4814 T8096 T8094 pobj months,at
R4815 T8097 T8096 prep of,months
R4816 T8098 T8097 pobj age,of
R4817 T8099 T8088 prep with,died
R4818 T8100 T8101 det an,phenotype
R4819 T8101 T8099 pobj phenotype,with
R4820 T8102 T8101 amod osteopetrotic,phenotype
R4821 T8103 T8104 punct [,48
R4822 T8104 T8088 parataxis 48,died
R4823 T8105 T8104 punct ],48
R4824 T8106 T8088 cc and,died
R4825 T8107 T8108 det the,defect
R4826 T8108 T8109 nsubjpass defect,attributed
R4827 T8109 T8088 conj attributed,died
R4828 T8110 T8109 auxpass was,attributed
R4829 T8111 T8109 prep to,attributed
R4830 T8112 T8113 amod defective,function
R4831 T8113 T8111 pobj function,to
R4832 T8114 T8113 compound osteoclast,function
R4833 T8115 T8116 punct [,55
R4834 T8116 T8109 parataxis 55,attributed
R4835 T8117 T8118 punct −,59
R4836 T8118 T8116 prep 59,55
R4837 T8119 T8116 punct ],55
R4838 T8120 T8078 punct .,shown
R4839 T8122 T8123 nsubj We,cultured
R4840 T8124 T8123 advmod therefore,cultured
R4841 T8125 T8126 amod mature,osteoclasts
R4842 T8126 T8123 dobj osteoclasts,cultured
R4843 T8127 T8126 acl harvested,osteoclasts
R4844 T8128 T8127 prep from,harvested
R4845 T8129 T8130 nmod Sam68,mice
R4846 T8130 T8128 pobj mice,from
R4847 T8131 T8129 punct +,Sam68
R4848 T8132 T8129 punct /,Sam68
R4849 T8133 T8129 punct +,Sam68
R4850 T8134 T8129 cc and,Sam68
R4851 T8135 T8129 conj Sam68,Sam68
R4852 T8136 T8135 punct −,Sam68
R4853 T8137 T8135 punct /,Sam68
R4854 T8138 T8135 punct −,Sam68
R4855 T8139 T8140 advmod ex,vivo
R4856 T8140 T8123 advmod vivo,cultured
R4857 T8141 T8123 prep on,cultured
R4858 T8142 T8143 compound dentin,slices
R4859 T8143 T8141 pobj slices,on
R4860 T8144 T8145 aux to,quantify
R4861 T8145 T8123 advcl quantify,cultured
R4862 T8146 T8147 poss their,capacity
R4863 T8147 T8145 dobj capacity,quantify
R4864 T8148 T8147 amod resorptive,capacity
R4865 T8149 T8123 punct .,cultured
R4866 T8151 T8152 det The,fact
R4867 T8152 T8153 nsubj fact,made
R4868 T8154 T8155 mark that,looked
R4869 T8155 T8152 acl looked,fact
R4870 T8156 T8157 nmod Sam68,osteoclasts
R4871 T8157 T8155 nsubj osteoclasts,looked
R4872 T8158 T8156 punct −,Sam68
R4873 T8159 T8156 punct /,Sam68
R4874 T8160 T8156 punct −,Sam68
R4875 T8161 T8155 cc and,looked
R4876 T8162 T8155 conj acted,looked
R4877 T8163 T8162 prep like,acted
R4878 T8164 T8165 nmod Sam68,osteoclasts
R4879 T8165 T8163 pobj osteoclasts,like
R4880 T8166 T8164 punct +,Sam68
R4881 T8167 T8164 punct /,Sam68
R4882 T8168 T8164 punct +,Sam68
R4883 T8169 T8170 advmod ex,vivo
R4884 T8170 T8162 advmod vivo,acted
R4885 T8171 T8170 cc and,vivo
R4886 T8172 T8173 advmod in,vivo
R4887 T8173 T8170 conj vivo,vivo
R4888 T8174 T8175 nsubj it,unlikely
R4889 T8175 T8153 ccomp unlikely,made
R4890 T8176 T8177 mark that,was
R4891 T8177 T8175 advcl was,unlikely
R4892 T8178 T8177 nsubj this,was
R4893 T8179 T8180 det the,source
R4894 T8180 T8177 attr source,was
R4895 T8181 T8180 amod primary,source
R4896 T8182 T8180 prep of,source
R4897 T8183 T8184 det the,difference
R4898 T8184 T8182 pobj difference,of
R4899 T8185 T8184 prep in,difference
R4900 T8186 T8187 compound bone,metabolism
R4901 T8187 T8185 pobj metabolism,in
R4902 T8188 T8177 prep in,was
R4903 T8189 T8190 nummod 12,month
R4904 T8190 T8192 npadvmod month,old
R4905 T8191 T8190 punct -,month
R4906 T8192 T8194 amod old,mice
R4907 T8193 T8192 punct -,old
R4908 T8194 T8188 pobj mice,in
R4909 T8195 T8194 nmod Sam68,mice
R4910 T8196 T8195 punct −,Sam68
R4911 T8197 T8195 punct /,Sam68
R4912 T8198 T8195 punct −,Sam68
R4913 T8199 T8153 punct .,made
R4914 T8201 T8202 det The,fact
R4915 T8202 T8203 nsubj fact,suggested
R4916 T8204 T8205 mark that,were
R4917 T8205 T8202 acl were,fact
R4918 T8206 T8207 det the,levels
R4919 T8207 T8205 nsubj levels,were
R4920 T8208 T8207 compound CTX,levels
R4921 T8209 T8205 acomp lower,were
R4922 T8210 T8205 prep in,were
R4923 T8211 T8212 amod young,mice
R4924 T8212 T8210 pobj mice,in
R4925 T8213 T8211 cc and,young
R4926 T8214 T8211 conj old,young
R4927 T8215 T8212 nmod Sam68,mice
R4928 T8216 T8215 punct −,Sam68
R4929 T8217 T8215 punct /,Sam68
R4930 T8218 T8215 punct −,Sam68
R4931 T8219 T8220 mark that,is
R4932 T8220 T8203 ccomp is,suggested
R4933 T8221 T8220 expl there,is
R4934 T8222 T8223 amod reduced,resorption
R4935 T8223 T8220 attr resorption,is
R4936 T8224 T8223 compound bone,resorption
R4937 T8225 T8223 prep compared,resorption
R4938 T8226 T8225 prep with,compared
R4939 T8227 T8228 amod wild,type
R4940 T8228 T8230 compound type,controls
R4941 T8229 T8228 punct -,type
R4942 T8230 T8226 pobj controls,with
R4943 T8231 T8230 compound littermate,controls
R4944 T8232 T8203 punct .,suggested
R4945 T8234 T8235 advmod However,occurred
R4946 T8236 T8235 punct ", ",occurred
R4947 T8237 T8238 det this,reduction
R4948 T8238 T8235 nsubj reduction,occurred
R4949 T8239 T8238 prep in,reduction
R4950 T8240 T8241 compound bone,resorption
R4951 T8241 T8239 pobj resorption,in
R4952 T8242 T8235 prep with,occurred
R4953 T8243 T8244 amod normal,activity
R4954 T8244 T8242 pobj activity,with
R4955 T8245 T8244 compound osteoclast,activity
R4956 T8246 T8235 punct ", ",occurred
R4957 T8247 T8248 mark as,assessed
R4958 T8248 T8235 advcl assessed,occurred
R4959 T8249 T8248 prep by,assessed
R4960 T8250 T8251 advmod in,vitro
R4961 T8251 T8252 amod vitro,culturing
R4962 T8252 T8249 pobj culturing,by
R4963 T8253 T8235 punct .,occurred
R4964 T8255 T8256 det These,observations
R4965 T8256 T8257 nsubj observations,are
R4966 T8258 T8257 acomp consistent,are
R4967 T8259 T8258 prep with,consistent
R4968 T8260 T8261 det the,mice
R4969 T8261 T8266 nsubj mice,having
R4970 T8262 T8261 nmod Sam68,mice
R4971 T8263 T8262 punct −,Sam68
R4972 T8264 T8262 punct /,Sam68
R4973 T8265 T8262 punct −,Sam68
R4974 T8266 T8259 pcomp having,with
R4975 T8267 T8268 det a,phenotype
R4976 T8268 T8266 dobj phenotype,having
R4977 T8269 T8270 npadvmod youth,like
R4978 T8270 T8268 amod like,phenotype
R4979 T8271 T8270 punct -,like
R4980 T8272 T8268 compound bone,phenotype
R4981 T8273 T8257 punct .,are
R4982 T8275 T8276 advmod However,is
R4983 T8277 T8276 punct ", ",is
R4984 T8278 T8276 nsubj it,is
R4985 T8279 T8276 advmod still,is
R4986 T8280 T8276 acomp possible,is
R4987 T8281 T8276 punct ", ",is
R4988 T8282 T8283 mark that,manifest
R4989 T8283 T8276 ccomp manifest,is
R4990 T8284 T8285 det a,impairment
R4991 T8285 T8283 nsubj impairment,manifest
R4992 T8286 T8285 amod mild,impairment
R4993 T8287 T8285 prep in,impairment
R4994 T8288 T8289 nmod Sam68,mice
R4995 T8289 T8293 compound mice,function
R4996 T8290 T8288 punct −,Sam68
R4997 T8291 T8288 punct /,Sam68
R4998 T8292 T8288 punct −,Sam68
R4999 T8293 T8287 pobj function,in
R5000 T8294 T8293 compound osteoclast,function
R5001 T8295 T8283 aux may,manifest
R5002 T8296 T8283 dobj itself,manifest
R5003 T8297 T8283 advmod later,manifest
R5004 T8298 T8297 prep in,later
R5005 T8299 T8298 pobj life,in
R5006 T8300 T8283 prep in,manifest
R5007 T8301 T8302 amod overall,accumulation
R5008 T8302 T8300 pobj accumulation,in
R5009 T8303 T8302 prep of,accumulation
R5010 T8304 T8303 pobj bone,of
R5011 T8305 T8276 cc and,is
R5012 T8306 T8307 nsubj this,require
R5013 T8307 T8276 conj require,is
R5014 T8308 T8307 aux will,require
R5015 T8309 T8310 amod further,studies
R5016 T8310 T8307 dobj studies,require
R5017 T8311 T8310 amod detailed,studies
R5018 T8312 T8276 punct .,is
R5019 T8314 T8315 advmod Ex,vivo
R5020 T8315 T8316 amod vivo,differentiation
R5021 T8316 T8317 nsubj differentiation,revealed
R5022 T8318 T8316 prep of,differentiation
R5023 T8319 T8320 amod primary,cells
R5024 T8320 T8318 pobj cells,of
R5025 T8321 T8322 nmod bone,marrow
R5026 T8322 T8320 nmod marrow,cells
R5027 T8323 T8320 amod stromal,cells
R5028 T8324 T8320 punct ", ",cells
R5029 T8325 T8320 acl harvested,cells
R5030 T8326 T8325 prep from,harvested
R5031 T8327 T8328 nmod Sam68,mice
R5032 T8328 T8326 pobj mice,from
R5033 T8329 T8327 punct +,Sam68
R5034 T8330 T8327 punct /,Sam68
R5035 T8331 T8327 punct +,Sam68
R5036 T8332 T8327 cc and,Sam68
R5037 T8333 T8327 conj Sam68,Sam68
R5038 T8334 T8333 punct −,Sam68
R5039 T8335 T8333 punct /,Sam68
R5040 T8336 T8333 punct −,Sam68
R5041 T8337 T8317 punct ", ",revealed
R5042 T8338 T8317 prep down,revealed
R5043 T8339 T8340 det the,lineage
R5044 T8340 T8338 pobj lineage,down
R5045 T8341 T8340 compound osteoblast,lineage
R5046 T8342 T8343 det an,advantage
R5047 T8343 T8317 dobj advantage,revealed
R5048 T8344 T8343 amod osteogenic,advantage
R5049 T8345 T8317 prep in,revealed
R5050 T8346 T8347 det the,cultures
R5051 T8347 T8345 pobj cultures,in
R5052 T8348 T8347 prep of,cultures
R5053 T8349 T8348 pobj cells,of
R5054 T8350 T8349 acl derived,cells
R5055 T8351 T8350 prep from,derived
R5056 T8352 T8353 det the,mice
R5057 T8353 T8351 pobj mice,from
R5058 T8354 T8353 nmod Sam68,mice
R5059 T8355 T8354 punct −,Sam68
R5060 T8356 T8354 punct /,Sam68
R5061 T8357 T8354 punct −,Sam68
R5062 T8358 T8317 punct .,revealed
R5063 T8360 T8361 nsubj It,be
R5064 T8362 T8361 aux will,be
R5065 T8363 T8361 acomp important,be
R5066 T8364 T8365 aux to,demonstrate
R5067 T8365 T8361 xcomp demonstrate,be
R5068 T8366 T8367 mark that,observed
R5069 T8367 T8365 ccomp observed,demonstrate
R5070 T8368 T8369 det a,effect
R5071 T8369 T8367 nsubjpass effect,observed
R5072 T8370 T8369 amod similar,effect
R5073 T8407 T8392 prep into,differentiated
R5074 T8371 T8367 auxpass is,observed
R5075 T8408 T8407 pobj osteoblasts,into
R5076 T8372 T8367 advcl using,observed
R5077 T8409 T8392 prep with,differentiated
R5078 T8410 T8409 pobj BMP2,with
R5079 T8411 T8389 punct .,observed
R5080 T8413 T8414 poss Our,findings
R5081 T8373 T8374 amod primary,cells
R5082 T8414 T8415 nsubj findings,indicate
R5083 T8416 T8417 mark that,develop
R5084 T8374 T8372 dobj cells,using
R5085 T8417 T8414 advcl develop,findings
R5086 T8418 T8419 amod aged,mice
R5087 T8375 T8376 nmod bone,marrow
R5088 T8419 T8417 nsubj mice,develop
R5089 T8420 T8419 nmod Sam68,mice
R5090 T8421 T8420 punct −,Sam68
R5091 T8376 T8374 nmod marrow,cells
R5092 T8422 T8420 punct /,Sam68
R5093 T8423 T8420 punct −,Sam68
R5094 T8377 T8374 amod stromal,cells
R5095 T8424 T8417 aux do,develop
R5096 T8425 T8417 neg not,develop
R5097 T8426 T8427 amod fatty,marrow
R5098 T8378 T8374 prep from,cells
R5099 T8427 T8417 dobj marrow,develop
R5100 T8428 T8427 compound bone,marrow
R5101 T8379 T8380 amod aged,mice
R5102 T8429 T8417 cc and,develop
R5103 T8430 T8431 mark that,have
R5104 T8431 T8417 conj have,develop
R5105 T8380 T8378 pobj mice,from
R5106 T8432 T8431 nsubj MEFs,have
R5107 T8433 T8432 acl derived,MEFs
R5108 T8434 T8433 prep from,derived
R5109 T8381 T8380 nmod Sam68,mice
R5110 T8435 T8436 nmod Sam68,mice
R5111 T8436 T8434 pobj mice,from
R5112 T8382 T8381 punct −,Sam68
R5113 T8437 T8435 punct −,Sam68
R5114 T8438 T8435 punct /,Sam68
R5115 T8383 T8381 punct /,Sam68
R5116 T8439 T8435 punct −,Sam68
R5117 T8440 T8441 amod impaired,differentiation
R5118 T8441 T8431 dobj differentiation,have
R5119 T8442 T8441 compound adipocyte,differentiation
R5120 T8384 T8381 punct −,Sam68
R5121 T8443 T8415 punct ", ",indicate
R5122 T8444 T8445 mark that,regulates
R5123 T8445 T8415 ccomp regulates,indicate
R5124 T8385 T8361 punct .,be
R5125 T8446 T8445 nsubj Sam68,regulates
R5126 T8447 T8448 preconj both,adipocyte
R5127 T8448 T8449 nmod adipocyte,differentiation
R5128 T8387 T8388 amod Similar,findings
R5129 T8449 T8445 dobj differentiation,regulates
R5130 T8450 T8448 cc and,adipocyte
R5131 T8451 T8448 conj osteoblast,adipocyte
R5132 T8452 T8415 punct .,indicate
R5133 T8454 T8455 det These,findings
R5134 T8455 T8456 nsubj findings,identify
R5135 T8388 T8389 nsubjpass findings,observed
R5136 T8390 T8389 auxpass were,observed
R5137 T8457 T8456 dobj Sam68,identify
R5138 T8458 T8456 prep as,identify
R5139 T8391 T8392 advmod when,differentiated
R5140 T8459 T8460 det the,protein
R5141 T8460 T8458 pobj protein,as
R5142 T8392 T8389 advcl differentiated,observed
R5143 T8461 T8460 amod first,protein
R5144 T8462 T8463 npadvmod RNA,binding
R5145 T8463 T8460 amod binding,protein
R5146 T8393 T8394 amod embryonic,cells
R5147 T8464 T8465 aux to,regulate
R5148 T8465 T8460 advcl regulate,protein
R5149 T8394 T8392 nsubjpass cells,differentiated
R5150 T8466 T8467 amod mesenchymal,differentiation
R5151 T8467 T8465 dobj differentiation,regulate
R5152 T8468 T8467 compound cell,differentiation
R5153 T8395 T8394 amod mesenchymal,cells
R5154 T8469 T8456 cc and,identify
R5155 T8470 T8471 det the,challenge
R5156 T8471 T8472 nsubj challenge,be
R5157 T8396 T8394 amod multipotential,cells
R5158 T8472 T8456 conj be,identify
R5159 T8473 T8472 aux will,be
R5160 T8474 T8475 aux to,identify
R5161 T8397 T8394 compound progenitor,cells
R5162 T8475 T8472 xcomp identify,be
R5163 T8476 T8477 det the,targets
R5164 T8477 T8475 dobj targets,identify
R5165 T8398 T8394 appos C3H10T1,cells
R5166 T8478 T8477 amod specific,targets
R5167 T8479 T8477 compound RNA,targets
R5168 T8399 T8398 punct /,C3H10T1
R5169 T8480 T8481 dep that,regulates
R5170 T8400 T8398 nummod 2,C3H10T1
R5171 T8481 T8477 relcl regulates,targets
R5172 T8482 T8481 nsubj it,regulates
R5173 T8483 T8481 prep during,regulates
R5174 T8401 T8394 acl treated,cells
R5175 T8484 T8485 det this,process
R5176 T8485 T8483 pobj process,during
R5177 T8486 T8472 punct .,be
R5178 T8402 T8401 prep with,treated
R5179 T8488 T8489 det The,fact
R5180 T8489 T8490 nsubj fact,raises
R5181 T8403 T8404 compound Sam68,shRNA
R5182 T8491 T8492 mark that,altered
R5183 T8492 T8489 acl altered,fact
R5184 T8404 T8402 pobj shRNA,with
R5185 T8405 T8392 punct ", ",differentiated
R5186 T8493 T8494 compound osteoblast,function
R5187 T8406 T8392 auxpass were,differentiated
R5188 T8494 T8492 nsubjpass function,altered
R5189 T8495 T8492 auxpass is,altered
R5190 T8496 T8492 prep in,altered
R5191 T8513 T8514 compound bone,mass
R5192 T8497 T8498 nmod Src,mice
R5193 T8498 T8496 pobj mice,in
R5194 T8499 T8497 punct −,Src
R5195 T8514 T8512 pobj mass,of
R5196 T8500 T8497 punct /,Src
R5197 T8501 T8497 punct −,Src
R5198 T8502 T8503 punct [,61
R5199 T8515 T8511 prep in,preservation
R5200 T8503 T8492 parataxis 61,altered
R5201 T8504 T8503 nummod 60,61
R5202 T8505 T8503 punct ",",61
R5203 T8516 T8517 det the,mice
R5204 T8506 T8503 punct ],61
R5205 T8507 T8508 det the,possibility
R5206 T8508 T8490 dobj possibility,raises
R5207 T8517 T8515 pobj mice,in
R5208 T8509 T8510 mark that,linked
R5209 T8510 T8508 acl linked,possibility
R5210 T8511 T8510 nsubjpass preservation,linked
R5211 T8518 T8517 nmod Sam68,mice
R5212 T8512 T8511 prep of,preservation
R5213 T8519 T8518 punct −,Sam68
R5214 T8520 T8518 punct /,Sam68
R5215 T8521 T8518 punct −,Sam68
R5216 T8522 T8510 aux could,linked
R5217 T8523 T8510 auxpass be,linked
R5218 T8524 T8510 prep with,linked
R5219 T8619 T8617 amod sympathetic,pathway
R5220 T8525 T8510 cc and,linked
R5221 T8620 T8619 punct -,sympathetic
R5222 T8621 T8615 acomp unaltered,is
R5223 T8622 T8615 prep in,is
R5224 T8526 T8510 conj regulated,linked
R5225 T8623 T8624 nmod Sam68,mice
R5226 T8527 T8526 agent by,regulated
R5227 T8624 T8622 pobj mice,in
R5228 T8528 T8526 dobj Src,regulated
R5229 T8625 T8623 punct −,Sam68
R5230 T8626 T8623 punct /,Sam68
R5231 T8529 T8490 punct .,raises
R5232 T8627 T8623 punct −,Sam68
R5233 T8531 T8532 det The,pathway
R5234 T8628 T8615 cc and,is
R5235 T8629 T8630 mark that,explain
R5236 T8630 T8615 conj explain,is
R5237 T8631 T8632 det the,lowering
R5238 T8632 T8630 nsubj lowering,explain
R5239 T8633 T8632 prep of,lowering
R5240 T8634 T8633 pobj leptin,of
R5241 T8532 T8533 nsubjpass pathway,identified
R5242 T8635 T8630 aux may,explain
R5243 T8636 T8637 det the,levels
R5244 T8637 T8630 dobj levels,explain
R5245 T8534 T8535 prep by,regulates
R5246 T8638 T8637 amod lower,levels
R5247 T8639 T8637 prep of,levels
R5248 T8640 T8639 pobj CTX,of
R5249 T8535 T8532 relcl regulates,pathway
R5250 T8641 T8637 prep in,levels
R5251 T8642 T8643 det the,serum
R5252 T8643 T8641 pobj serum,in
R5253 T8536 T8534 pobj which,by
R5254 T8644 T8643 prep of,serum
R5255 T8645 T8646 nmod Sam68,mice
R5256 T8646 T8644 pobj mice,of
R5257 T8537 T8535 nsubj leptin,regulates
R5258 T8647 T8645 punct −,Sam68
R5259 T8648 T8645 punct /,Sam68
R5260 T8649 T8645 punct −,Sam68
R5261 T8538 T8539 compound bone,resorption
R5262 T8650 T8612 punct .,suggest
R5263 T8652 T8653 det These,findings
R5264 T8539 T8535 dobj resorption,regulates
R5265 T8653 T8654 nsubj findings,suggest
R5266 T8654 T8655 ccomp suggest,results
R5267 T8540 T8533 auxpass was,identified
R5268 T8656 T8657 mark that,regulating
R5269 T8657 T8654 ccomp regulating,suggest
R5270 T8541 T8542 aux to,involve
R5271 T8658 T8657 nsubj Sam68,regulating
R5272 T8659 T8657 aux may,regulating
R5273 T8542 T8533 xcomp involve,identified
R5274 T8660 T8657 aux be,regulating
R5275 T8661 T8662 compound bone,metabolism
R5276 T8662 T8657 dobj metabolism,regulating
R5277 T8543 T8544 det the,system
R5278 T8663 T8657 prep at,regulating
R5279 T8664 T8665 nummod two,levels
R5280 T8665 T8663 pobj levels,at
R5281 T8544 T8542 dobj system,involve
R5282 T8666 T8665 amod different,levels
R5283 T8667 T8655 punct : ,results
R5284 T8668 T8669 punct (,1
R5285 T8545 T8544 amod sympathetic,system
R5286 T8669 T8655 meta 1,results
R5287 T8670 T8669 punct ),1
R5288 T8671 T8672 det the,absence
R5289 T8672 T8655 nsubj absence,results
R5290 T8673 T8672 prep of,absence
R5291 T8674 T8673 pobj Sam68,of
R5292 T8546 T8544 amod nervous,system
R5293 T8675 T8655 prep in,results
R5294 T8676 T8677 amod lower,levels
R5295 T8677 T8675 pobj levels,in
R5296 T8547 T8544 acl relaying,system
R5297 T8678 T8677 compound leptin,levels
R5298 T8679 T8680 dep that,reduce
R5299 T8680 T8677 relcl reduce,levels
R5300 T8548 T8547 prep to,relaying
R5301 T8681 T8680 aux may,reduce
R5302 T8682 T8683 compound bone,resorption
R5303 T8683 T8680 dobj resorption,reduce
R5304 T8549 T8550 det the,osteoblasts
R5305 T8684 T8680 prep via,reduce
R5306 T8685 T8686 det the,system
R5307 T8686 T8684 pobj system,via
R5308 T8550 T8548 pobj osteoblasts,to
R5309 T8687 T8686 amod sympathetic,system
R5310 T8688 T8686 amod nervous,system
R5311 T8689 T8655 cc and,results
R5312 T8551 T8547 prep via,relaying
R5313 T8690 T8691 punct (,2
R5314 T8691 T8692 meta 2,favors
R5315 T8692 T8655 conj favors,results
R5316 T8552 T8553 det the,pathway
R5317 T8693 T8691 punct ),2
R5318 T8694 T8695 det the,absence
R5319 T8695 T8692 nsubj absence,favors
R5320 T8553 T8551 pobj pathway,via
R5321 T8696 T8695 prep of,absence
R5322 T8697 T8696 pobj Sam68,of
R5323 T8698 T8699 nmod osteoblast,differentiation
R5324 T8554 T8555 npadvmod β,adrenergic
R5325 T8699 T8692 dobj differentiation,favors
R5326 T8700 T8698 punct ", ",osteoblast
R5327 T8701 T8702 advmod rather,than
R5328 T8555 T8553 amod adrenergic,pathway
R5329 T8702 T8698 cc than,osteoblast
R5330 T8703 T8698 conj adipocyte,osteoblast
R5331 T8556 T8555 punct -,adrenergic
R5332 T8704 T8699 punct ", ",differentiation
R5333 T8705 T8655 punct .,results
R5334 T8557 T8547 advcl leading,relaying
R5335 T8707 T8708 prep In,define
R5336 T8558 T8557 prep to,leading
R5337 T8709 T8707 pobj conclusion,In
R5338 T8710 T8708 punct ", ",define
R5339 T8711 T8712 poss our,data
R5340 T8559 T8560 det the,release
R5341 T8560 T8558 pobj release,to
R5342 T8712 T8708 nsubj data,define
R5343 T8713 T8714 det a,role
R5344 T8714 T8708 dobj role,define
R5345 T8561 T8560 prep of,release
R5346 T8715 T8714 amod physiologic,role
R5347 T8716 T8714 prep for,role
R5348 T8562 T8563 compound growth,factors
R5349 T8717 T8716 pobj Sam68,for
R5350 T8718 T8714 prep in,role
R5351 T8563 T8561 pobj factors,of
R5352 T8564 T8563 prep including,factors
R5353 T8719 T8720 compound bone,metabolism
R5354 T8565 T8564 pobj RANKL,including
R5355 T8720 T8718 pobj metabolism,in
R5356 T8566 T8567 dep that,causes
R5357 T8721 T8720 cc and,metabolism
R5358 T8722 T8723 nmod bone,marrow
R5359 T8567 T8563 relcl causes,factors
R5360 T8723 T8724 nmod marrow,differentiation
R5361 T8724 T8720 conj differentiation,metabolism
R5362 T8568 T8569 det the,osteoclasts
R5363 T8569 T8570 nsubj osteoclasts,thrive
R5364 T8725 T8726 amod mesenchymal,cell
R5365 T8570 T8567 ccomp thrive,causes
R5366 T8726 T8724 compound cell,differentiation
R5367 T8727 T8726 compound stem,cell
R5368 T8571 T8570 aux to,thrive
R5369 T8728 T8708 punct .,define
R5370 T8730 T8731 det The,phenotype
R5371 T8572 T8573 punct [,8
R5372 T8731 T8733 nsubj phenotype,imply
R5373 T8732 T8731 compound bone,phenotype
R5374 T8573 T8533 parataxis 8,identified
R5375 T8734 T8731 acl observed,phenotype
R5376 T8735 T8734 prep in,observed
R5377 T8574 T8573 punct ",",8
R5378 T8736 T8737 nmod Sam68,mice
R5379 T8737 T8735 pobj mice,in
R5380 T8738 T8736 punct −,Sam68
R5381 T8575 T8573 appos 18,8
R5382 T8739 T8736 punct /,Sam68
R5383 T8740 T8736 punct −,Sam68
R5384 T8576 T8577 punct –,20
R5385 T8741 T8742 mark that,prevent
R5386 T8742 T8733 ccomp prevent,imply
R5387 T8743 T8742 nsubj inhibitors,prevent
R5388 T8577 T8575 prep 20,18
R5389 T8744 T8743 prep of,inhibitors
R5390 T8745 T8744 pobj Sam68,of
R5391 T8746 T8742 aux could,prevent
R5392 T8747 T8748 npadvmod age,related
R5393 T8748 T8750 amod related,loss
R5394 T8749 T8748 punct -,related
R5395 T8578 T8573 punct ],8
R5396 T8750 T8742 dobj loss,prevent
R5397 T8751 T8750 compound bone,loss
R5398 T8579 T8533 punct .,identified
R5399 T8752 T8733 punct .,imply
R5400 T8754 T8755 advmod Furthermore,suggest
R5401 T8581 T8582 det The,lowering
R5402 T8756 T8755 punct ", ",suggest
R5403 T8757 T8758 det the,results
R5404 T8758 T8755 nsubj results,suggest
R5405 T8582 T8583 nsubj lowering,is
R5406 T8759 T8755 advmod also,suggest
R5407 T8760 T8761 mark that,influence
R5408 T8761 T8755 ccomp influence,suggest
R5409 T8584 T8582 prep of,lowering
R5410 T8762 T8763 compound Sam68,levels
R5411 T8763 T8761 nsubj levels,influence
R5412 T8764 T8763 compound expression,levels
R5413 T8765 T8763 punct ", ",levels
R5414 T8585 T8586 compound leptin,levels
R5415 T8766 T8763 conj hypomorphism,levels
R5416 T8767 T8766 punct ", ",hypomorphism
R5417 T8768 T8766 cc and,hypomorphism
R5418 T8586 T8584 pobj levels,of
R5419 T8769 T8766 conj mutations,hypomorphism
R5420 T8770 T8763 prep in,levels
R5421 T8771 T8770 pobj humans,in
R5422 T8587 T8582 prep in,lowering
R5423 T8772 T8761 aux may,influence
R5424 T8773 T8761 dobj susceptibility,influence
R5425 T8774 T8773 prep to,susceptibility
R5426 T8588 T8589 amod aged,mice
R5427 T8775 T8776 compound marrow,adipocyte
R5428 T8776 T8777 compound adipocyte,accumulation
R5429 T8777 T8774 pobj accumulation,to
R5430 T8589 T8587 pobj mice,in
R5431 T8778 T8777 cc and,accumulation
R5432 T8779 T8777 conj osteoporosis,accumulation
R5433 T8780 T8755 punct .,suggest
R5434 T8590 T8589 nmod Sam68,mice
R5435 T8782 T8783 poss Our,findings
R5436 T8783 T8784 nsubj findings,identify
R5437 T8591 T8590 punct −,Sam68
R5438 T8785 T8784 advmod also,identify
R5439 T8786 T8787 det a,model
R5440 T8592 T8590 punct /,Sam68
R5441 T8787 T8784 dobj model,identify
R5442 T8788 T8787 amod new,model
R5443 T8789 T8787 compound animal,model
R5444 T8790 T8791 aux to,study
R5445 T8791 T8787 advcl study,model
R5446 T8792 T8793 amod aging,loss
R5447 T8593 T8590 punct −,Sam68
R5448 T8793 T8791 dobj loss,study
R5449 T8794 T8793 compound bone,loss
R5450 T8594 T8583 acomp consistent,is
R5451 T8795 T8784 punct .,identify
R5452 T8595 T8594 prep with,consistent
R5453 T8596 T8597 det these,mice
R5454 T8597 T8598 nsubj mice,having
R5455 T8598 T8595 pcomp having,with
R5456 T8599 T8600 det a,mass
R5457 T8600 T8598 dobj mass,having
R5458 T8601 T8600 amod high,mass
R5459 T8602 T8600 compound bone,mass
R5460 T8603 T8598 prep compared,having
R5461 T8604 T8603 prep with,compared
R5462 T8605 T8606 poss their,littermates
R5463 T8606 T8604 pobj littermates,with
R5464 T8607 T8606 amod aged,littermates
R5465 T8608 T8583 punct .,is
R5466 T8610 T8611 det These,data
R5467 T8611 T8612 nsubj data,suggest
R5468 T8613 T8612 aux would,suggest
R5469 T8614 T8615 mark that,is
R5470 T8615 T8612 advcl is,suggest
R5471 T8616 T8617 det the,pathway
R5472 T8617 T8615 nsubj pathway,is
R5473 T8618 T8619 npadvmod leptin,sympathetic