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PMC:1315279 / 3043-7492 JSONTXT 5 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T1057 13-19 IN denotes During
T1059 20-28 JJ denotes skeletal
T1060 29-40 NN denotes development
T1061 40-42 , denotes ,
T1062 42-45 DT denotes the
T1064 46-54 JJ denotes anabolic
T1063 55-63 NN denotes activity
T1065 64-66 IN denotes of
T1066 67-78 NNS denotes osteoblasts
T1067 79-80 -LRB- denotes [
T1068 80-81 CD denotes 1
T1069 81-82 -RRB- denotes ]
T1070 83-85 VBZ denotes is
T1058 86-93 VBN denotes favored
T1071 94-98 IN denotes over
T1072 99-102 DT denotes the
T1074 103-112 JJ denotes catabolic
T1073 113-121 NN denotes activity
T1075 122-124 IN denotes of
T1076 125-136 NNS denotes osteoclasts
T1077 137-138 -LRB- denotes [
T1078 138-139 CD denotes 2
T1079 139-140 -RRB- denotes ]
T1080 140-142 , denotes ,
T1081 142-147 WDT denotes which
T1082 148-155 VBZ denotes results
T1083 156-158 IN denotes in
T1084 159-160 DT denotes a
T1086 161-164 JJ denotes net
T1085 165-169 NN denotes gain
T1087 170-172 IN denotes in
T1088 173-177 NN denotes bone
T1089 178-182 NN denotes mass
T1090 182-183 . denotes .
T1091 183-319 sentence denotes At skeletal maturity, bone mass is maintained through the balanced activity of osteoblasts and osteoclasts during the remodeling cycle.
T1092 184-186 IN denotes At
T1094 187-195 JJ denotes skeletal
T1095 196-204 NN denotes maturity
T1096 204-206 , denotes ,
T1097 206-210 NN denotes bone
T1098 211-215 NN denotes mass
T1099 216-218 VBZ denotes is
T1093 219-229 VBN denotes maintained
T1100 230-237 IN denotes through
T1101 238-241 DT denotes the
T1103 242-250 VBN denotes balanced
T1102 251-259 NN denotes activity
T1104 260-262 IN denotes of
T1105 263-274 NNS denotes osteoblasts
T1106 275-278 CC denotes and
T1107 279-290 NNS denotes osteoclasts
T1108 291-297 IN denotes during
T1109 298-301 DT denotes the
T1111 302-312 NN denotes remodeling
T1110 313-318 NN denotes cycle
T1112 318-319 . denotes .
T1113 319-459 sentence denotes During skeletal aging, there is a shift in the balance that favors osteoclast over osteoblast activity, which results in net bone loss [3].
T1114 320-326 IN denotes During
T1116 327-335 JJ denotes skeletal
T1117 336-341 NN denotes aging
T1118 341-343 , denotes ,
T1119 343-348 EX denotes there
T1115 349-351 VBZ denotes is
T1120 352-353 DT denotes a
T1121 354-359 NN denotes shift
T1122 360-362 IN denotes in
T1123 363-366 DT denotes the
T1124 367-374 NN denotes balance
T1125 375-379 WDT denotes that
T1126 380-386 VBZ denotes favors
T1127 387-397 NN denotes osteoclast
T1128 398-402 IN denotes over
T1129 403-413 NN denotes osteoblast
T1130 414-422 NN denotes activity
T1131 422-424 , denotes ,
T1132 424-429 WDT denotes which
T1133 430-437 VBZ denotes results
T1134 438-440 IN denotes in
T1135 441-444 JJ denotes net
T1137 445-449 NN denotes bone
T1136 450-454 NN denotes loss
T1138 455-456 -LRB- denotes [
T1139 456-457 CD denotes 3
T1140 457-458 -RRB- denotes ]
T1141 458-459 . denotes .
T1142 459-761 sentence denotes The amount and rate at which bone is gained during development and lost during aging are determined in large part by genetics [4–6] but also by physical activity and by alterations in the availability and response of bone cells to circulating hormones [7–9] and locally derived growth factors [10,11].
T1143 460-463 DT denotes The
T1144 464-470 NN denotes amount
T1146 471-474 CC denotes and
T1147 475-479 NN denotes rate
T1148 480-482 IN denotes at
T1150 483-488 WDT denotes which
T1151 489-493 NN denotes bone
T1152 494-496 VBZ denotes is
T1149 497-503 VBN denotes gained
T1153 504-510 IN denotes during
T1154 511-522 NN denotes development
T1155 523-526 CC denotes and
T1156 527-531 VBN denotes lost
T1157 532-538 IN denotes during
T1158 539-544 NN denotes aging
T1159 545-548 VBP denotes are
T1145 549-559 VBN denotes determined
T1160 560-562 IN denotes in
T1161 563-568 JJ denotes large
T1162 569-573 NN denotes part
T1163 574-576 IN denotes by
T1164 577-585 NN denotes genetics
T1165 586-587 -LRB- denotes [
T1166 587-588 CD denotes 4
T1167 588-589 SYM denotes –
T1168 589-590 CD denotes 6
T1169 590-591 -RRB- denotes ]
T1170 592-595 CC denotes but
T1171 596-600 RB denotes also
T1172 601-603 IN denotes by
T1173 604-612 JJ denotes physical
T1174 613-621 NN denotes activity
T1175 622-625 CC denotes and
T1176 626-628 IN denotes by
T1177 629-640 NNS denotes alterations
T1178 641-643 IN denotes in
T1179 644-647 DT denotes the
T1180 648-660 NN denotes availability
T1181 661-664 CC denotes and
T1182 665-673 NN denotes response
T1183 674-676 IN denotes of
T1184 677-681 NN denotes bone
T1185 682-687 NNS denotes cells
T1186 688-690 IN denotes to
T1187 691-702 VBG denotes circulating
T1188 703-711 NNS denotes hormones
T1189 712-713 -LRB- denotes [
T1190 713-714 CD denotes 7
T1191 714-715 SYM denotes –
T1192 715-716 CD denotes 9
T1193 716-717 -RRB- denotes ]
T1194 718-721 CC denotes and
T1195 722-729 RB denotes locally
T1196 730-737 VBN denotes derived
T1198 738-744 NN denotes growth
T1197 745-752 NNS denotes factors
T1199 753-754 -LRB- denotes [
T1201 754-756 CD denotes 10
T1202 756-757 , denotes ,
T1200 757-759 CD denotes 11
T1203 759-760 -RRB- denotes ]
T1204 760-761 . denotes .
T1205 761-950 sentence denotes Whereas genetic-based studies have provided novel insights into the pathways that regulate bone development [12–14], relatively little is known about the etiology of age-related bone loss.
T1206 762-769 IN denotes Whereas
T1208 770-777 JJ denotes genetic
T1210 777-778 HYPH denotes -
T1209 778-783 VBN denotes based
T1211 784-791 NNS denotes studies
T1212 792-796 VBP denotes have
T1207 797-805 VBN denotes provided
T1214 806-811 JJ denotes novel
T1215 812-820 NNS denotes insights
T1216 821-825 IN denotes into
T1217 826-829 DT denotes the
T1218 830-838 NNS denotes pathways
T1219 839-843 WDT denotes that
T1220 844-852 VBP denotes regulate
T1221 853-857 NN denotes bone
T1222 858-869 NN denotes development
T1223 870-871 -LRB- denotes [
T1224 871-873 CD denotes 12
T1225 873-874 SYM denotes –
T1226 874-876 CD denotes 14
T1227 876-877 -RRB- denotes ]
T1228 877-879 , denotes ,
T1229 879-889 RB denotes relatively
T1230 890-896 JJ denotes little
T1231 897-899 VBZ denotes is
T1213 900-905 VBN denotes known
T1232 906-911 IN denotes about
T1233 912-915 DT denotes the
T1234 916-924 NN denotes etiology
T1235 925-927 IN denotes of
T1236 928-931 NN denotes age
T1238 931-932 HYPH denotes -
T1237 932-939 VBN denotes related
T1240 940-944 NN denotes bone
T1239 945-949 NN denotes loss
T1241 949-950 . denotes .
T1242 950-1108 sentence denotes Increased bone resorption in elderly men and women is associated with a reduction in bone mass and an increase in circulating levels of bone biomarkers [15].
T1243 951-960 VBN denotes Increased
T1245 961-965 NN denotes bone
T1244 966-976 NN denotes resorption
T1247 977-979 IN denotes in
T1248 980-987 JJ denotes elderly
T1249 988-991 NNS denotes men
T1250 992-995 CC denotes and
T1251 996-1001 NNS denotes women
T1252 1002-1004 VBZ denotes is
T1246 1005-1015 VBN denotes associated
T1253 1016-1020 IN denotes with
T1254 1021-1022 DT denotes a
T1255 1023-1032 NN denotes reduction
T1256 1033-1035 IN denotes in
T1257 1036-1040 NN denotes bone
T1258 1041-1045 NN denotes mass
T1259 1046-1049 CC denotes and
T1260 1050-1052 DT denotes an
T1261 1053-1061 NN denotes increase
T1262 1062-1064 IN denotes in
T1263 1065-1076 VBG denotes circulating
T1264 1077-1083 NNS denotes levels
T1265 1084-1086 IN denotes of
T1266 1087-1091 NN denotes bone
T1267 1092-1102 NNS denotes biomarkers
T1268 1103-1104 -LRB- denotes [
T1269 1104-1106 CD denotes 15
T1270 1106-1107 -RRB- denotes ]
T1271 1107-1108 . denotes .
T1272 1108-1397 sentence denotes These changes have been attributed primarily to nutritional deficits resulting in alterations in the parathyroid hormone–vitamin D axis [16], to gonadal hormone deficiency [17], to leptin levels and the sympathetic nervous system [8,18–20], and to alterations in bone cell apoptosis [21].
T1273 1109-1114 DT denotes These
T1274 1115-1122 NNS denotes changes
T1276 1123-1127 VBP denotes have
T1277 1128-1132 VBN denotes been
T1275 1133-1143 VBN denotes attributed
T1278 1144-1153 RB denotes primarily
T1279 1154-1156 IN denotes to
T1280 1157-1168 JJ denotes nutritional
T1281 1169-1177 NNS denotes deficits
T1282 1178-1187 VBG denotes resulting
T1283 1188-1190 IN denotes in
T1284 1191-1202 NNS denotes alterations
T1285 1203-1205 IN denotes in
T1286 1206-1209 DT denotes the
T1288 1210-1221 NN denotes parathyroid
T1289 1222-1229 NN denotes hormone
T1290 1229-1230 HYPH denotes –
T1291 1230-1237 NN denotes vitamin
T1292 1238-1239 NN denotes D
T1287 1240-1244 NN denotes axis
T1293 1245-1246 -LRB- denotes [
T1294 1246-1248 CD denotes 16
T1295 1248-1249 -RRB- denotes ]
T1296 1249-1251 , denotes ,
T1297 1251-1253 IN denotes to
T1298 1254-1261 JJ denotes gonadal
T1300 1262-1269 NN denotes hormone
T1299 1270-1280 NN denotes deficiency
T1301 1281-1282 -LRB- denotes [
T1302 1282-1284 CD denotes 17
T1303 1284-1285 -RRB- denotes ]
T1304 1285-1287 , denotes ,
T1305 1287-1289 IN denotes to
T1306 1290-1296 NN denotes leptin
T1307 1297-1303 NNS denotes levels
T1308 1304-1307 CC denotes and
T1309 1308-1311 DT denotes the
T1311 1312-1323 JJ denotes sympathetic
T1312 1324-1331 JJ denotes nervous
T1310 1332-1338 NN denotes system
T1313 1339-1340 -LRB- denotes [
T1314 1340-1341 CD denotes 8
T1315 1341-1342 , denotes ,
T1316 1342-1344 CD denotes 18
T1317 1344-1345 SYM denotes –
T1318 1345-1347 CD denotes 20
T1319 1347-1348 -RRB- denotes ]
T1320 1348-1350 , denotes ,
T1321 1350-1353 CC denotes and
T1322 1354-1356 IN denotes to
T1323 1357-1368 NNS denotes alterations
T1324 1369-1371 IN denotes in
T1325 1372-1376 NN denotes bone
T1326 1377-1381 NN denotes cell
T1327 1382-1391 NN denotes apoptosis
T1328 1392-1393 -LRB- denotes [
T1329 1393-1395 CD denotes 21
T1330 1395-1396 -RRB- denotes ]
T1331 1396-1397 . denotes .
T1332 1397-1629 sentence denotes Bone loss in the elderly has also been attributed to alterations in the response of bone marrow stromal cells to their microenvironment that favors differentiation down the adipocyte lineage rather than the osteoblast lineage [22].
T1333 1398-1402 NN denotes Bone
T1334 1403-1407 NN denotes loss
T1336 1408-1410 IN denotes in
T1337 1411-1414 DT denotes the
T1338 1415-1422 JJ denotes elderly
T1339 1423-1426 VBZ denotes has
T1340 1427-1431 RB denotes also
T1341 1432-1436 VBN denotes been
T1335 1437-1447 VBN denotes attributed
T1342 1448-1450 IN denotes to
T1343 1451-1462 NNS denotes alterations
T1344 1463-1465 IN denotes in
T1345 1466-1469 DT denotes the
T1346 1470-1478 NN denotes response
T1347 1479-1481 IN denotes of
T1348 1482-1486 NN denotes bone
T1349 1487-1493 NN denotes marrow
T1351 1494-1501 JJ denotes stromal
T1350 1502-1507 NNS denotes cells
T1352 1508-1510 IN denotes to
T1353 1511-1516 PRP$ denotes their
T1354 1517-1533 NN denotes microenvironment
T1355 1534-1538 WDT denotes that
T1356 1539-1545 VBZ denotes favors
T1357 1546-1561 NN denotes differentiation
T1358 1562-1566 IN denotes down
T1359 1567-1570 DT denotes the
T1361 1571-1580 NN denotes adipocyte
T1360 1581-1588 NN denotes lineage
T1362 1589-1595 RB denotes rather
T1363 1596-1600 IN denotes than
T1364 1601-1604 DT denotes the
T1366 1605-1615 NN denotes osteoblast
T1365 1616-1623 NN denotes lineage
T1367 1624-1625 -LRB- denotes [
T1368 1625-1627 CD denotes 22
T1369 1627-1628 -RRB- denotes ]
T1370 1628-1629 . denotes .
T1371 1629-1761 sentence denotes Aging has long been associated with an increase in marrow fat, where the generation of adipocytes is favored over osteoblasts [23].
T1372 1630-1635 NN denotes Aging
T1374 1636-1639 VBZ denotes has
T1375 1640-1644 RB denotes long
T1376 1645-1649 VBN denotes been
T1373 1650-1660 VBN denotes associated
T1377 1661-1665 IN denotes with
T1378 1666-1668 DT denotes an
T1379 1669-1677 NN denotes increase
T1380 1678-1680 IN denotes in
T1381 1681-1687 NN denotes marrow
T1382 1688-1691 NN denotes fat
T1383 1691-1693 , denotes ,
T1384 1693-1698 WRB denotes where
T1386 1699-1702 DT denotes the
T1387 1703-1713 NN denotes generation
T1388 1714-1716 IN denotes of
T1389 1717-1727 NNS denotes adipocytes
T1390 1728-1730 VBZ denotes is
T1385 1731-1738 VBN denotes favored
T1391 1739-1743 IN denotes over
T1392 1744-1755 NNS denotes osteoblasts
T1393 1756-1757 -LRB- denotes [
T1394 1757-1759 CD denotes 23
T1395 1759-1760 -RRB- denotes ]
T1396 1760-1761 . denotes .
T1397 1761-1981 sentence denotes Osteoblasts and adipocytes are derived from a common mesenchymal precursor cell present in bone marrow, and the factors that control this age-induced switch toward adipogenic differentiation is not well understood [24].
T1398 1762-1773 NNS denotes Osteoblasts
T1400 1774-1777 CC denotes and
T1401 1778-1788 NNS denotes adipocytes
T1402 1789-1792 VBP denotes are
T1399 1793-1800 VBN denotes derived
T1403 1801-1805 IN denotes from
T1404 1806-1807 DT denotes a
T1406 1808-1814 JJ denotes common
T1407 1815-1826 JJ denotes mesenchymal
T1408 1827-1836 NN denotes precursor
T1405 1837-1841 NN denotes cell
T1409 1842-1849 JJ denotes present
T1410 1850-1852 IN denotes in
T1411 1853-1857 NN denotes bone
T1412 1858-1864 NN denotes marrow
T1413 1864-1866 , denotes ,
T1414 1866-1869 CC denotes and
T1415 1870-1873 DT denotes the
T1416 1874-1881 NNS denotes factors
T1418 1882-1886 WDT denotes that
T1419 1887-1894 VBP denotes control
T1420 1895-1899 DT denotes this
T1422 1900-1903 NN denotes age
T1424 1903-1904 HYPH denotes -
T1423 1904-1911 VBN denotes induced
T1421 1912-1918 NN denotes switch
T1425 1919-1925 IN denotes toward
T1426 1926-1936 JJ denotes adipogenic
T1427 1937-1952 NN denotes differentiation
T1428 1953-1955 VBZ denotes is
T1429 1956-1959 RB denotes not
T1430 1960-1964 RB denotes well
T1417 1965-1975 VBN denotes understood
T1431 1976-1977 -LRB- denotes [
T1432 1977-1979 CD denotes 24
T1433 1979-1980 -RRB- denotes ]
T1434 1980-1981 . denotes .
T1435 1981-2262 sentence denotes While several transcriptional regulatory proteins have been associated with cell fate determination of bone marrow mesenchymal cells, including peroxisome proliferator–activated receptor γ (PPARγ) and KLF5 [25–30], the role of RNA binding proteins in this process remains unknown.
T1436 1982-1987 IN denotes While
T1438 1988-1995 JJ denotes several
T1440 1996-2011 JJ denotes transcriptional
T1441 2012-2022 JJ denotes regulatory
T1439 2023-2031 NN denotes proteins
T1442 2032-2036 VBP denotes have
T1443 2037-2041 VBN denotes been
T1437 2042-2052 VBN denotes associated
T1445 2053-2057 IN denotes with
T1446 2058-2062 NN denotes cell
T1448 2063-2067 NN denotes fate
T1447 2068-2081 NN denotes determination
T1449 2082-2084 IN denotes of
T1450 2085-2089 NN denotes bone
T1451 2090-2096 NN denotes marrow
T1453 2097-2108 JJ denotes mesenchymal
T1452 2109-2114 NNS denotes cells
T1454 2114-2116 , denotes ,
T1455 2116-2125 VBG denotes including
T1456 2126-2136 NN denotes peroxisome
T1458 2137-2149 NN denotes proliferator
T1460 2149-2150 HYPH denotes –
T1459 2150-2159 VBN denotes activated
T1457 2160-2168 NN denotes receptor
T1461 2169-2170 SYM denotes γ
T1462 2171-2172 -LRB- denotes (
T1463 2172-2177 NN denotes PPARγ
T1464 2177-2178 -RRB- denotes )
T1465 2179-2182 CC denotes and
T1466 2183-2187 NN denotes KLF5
T1467 2188-2189 -LRB- denotes [
T1468 2189-2191 CD denotes 25
T1469 2191-2192 SYM denotes –
T1470 2192-2194 CD denotes 30
T1471 2194-2195 -RRB- denotes ]
T1472 2195-2197 , denotes ,
T1473 2197-2200 DT denotes the
T1474 2201-2205 NN denotes role
T1475 2206-2208 IN denotes of
T1476 2209-2212 NN denotes RNA
T1478 2213-2220 NN denotes binding
T1477 2221-2229 NN denotes proteins
T1479 2230-2232 IN denotes in
T1480 2233-2237 DT denotes this
T1481 2238-2245 NN denotes process
T1444 2246-2253 VBZ denotes remains
T1482 2254-2261 JJ denotes unknown
T1483 2261-2262 . denotes .
T1484 2262-2348 sentence denotes RNA binding proteins of the KH type are known regulators of cellular differentiation.
T1485 2263-2266 NN denotes RNA
T1487 2267-2274 NN denotes binding
T1486 2275-2283 NN denotes proteins
T1489 2284-2286 IN denotes of
T1490 2287-2290 DT denotes the
T1492 2291-2293 NN denotes KH
T1491 2294-2298 NN denotes type
T1488 2299-2302 VBP denotes are
T1493 2303-2308 JJ denotes known
T1494 2309-2319 NNS denotes regulators
T1495 2320-2322 IN denotes of
T1496 2323-2331 JJ denotes cellular
T1497 2332-2347 NN denotes differentiation
T1498 2347-2348 . denotes .
T1499 2348-2538 sentence denotes For example, expression defects in the KH domain proteins NOVA and FMRP are known to cause paraneoplastic neurologic disorders [31] and the fragile X syndrome, respectively, in humans [32].
T1500 2349-2352 IN denotes For
T1502 2353-2360 NN denotes example
T1503 2360-2362 , denotes ,
T1504 2362-2372 NN denotes expression
T1505 2373-2380 NNS denotes defects
T1506 2381-2383 IN denotes in
T1507 2384-2387 DT denotes the
T1509 2388-2390 NN denotes KH
T1510 2391-2397 NN denotes domain
T1508 2398-2406 NN denotes proteins
T1511 2407-2411 NN denotes NOVA
T1512 2412-2415 CC denotes and
T1513 2416-2420 NN denotes FMRP
T1514 2421-2424 VBP denotes are
T1501 2425-2430 VBN denotes known
T1515 2431-2433 TO denotes to
T1516 2434-2439 VB denotes cause
T1517 2440-2454 JJ denotes paraneoplastic
T1519 2455-2465 JJ denotes neurologic
T1518 2466-2475 NNS denotes disorders
T1520 2476-2477 -LRB- denotes [
T1521 2477-2479 CD denotes 31
T1522 2479-2480 -RRB- denotes ]
T1523 2481-2484 CC denotes and
T1524 2485-2488 DT denotes the
T1526 2489-2496 JJ denotes fragile
T1527 2497-2498 NN denotes X
T1525 2499-2507 NN denotes syndrome
T1528 2507-2509 , denotes ,
T1529 2509-2521 RB denotes respectively
T1530 2521-2523 , denotes ,
T1531 2523-2525 IN denotes in
T1532 2526-2532 NNS denotes humans
T1533 2533-2534 -LRB- denotes [
T1534 2534-2536 CD denotes 32
T1535 2536-2537 -RRB- denotes ]
T1536 2537-2538 . denotes .
T1537 2538-2673 sentence denotes The phenotype of the quaking viable mice suggests a role for the QUAKING RNA binding protein in oligodendrocytes and myelination [33].
T1538 2539-2542 DT denotes The
T1539 2543-2552 NN denotes phenotype
T1541 2553-2555 IN denotes of
T1542 2556-2559 DT denotes the
T1544 2560-2567 NN denotes quaking
T1545 2568-2574 JJ denotes viable
T1543 2575-2579 NNS denotes mice
T1540 2580-2588 VBZ denotes suggests
T1546 2589-2590 DT denotes a
T1547 2591-2595 NN denotes role
T1548 2596-2599 IN denotes for
T1549 2600-2603 DT denotes the
T1551 2604-2611 NN denotes QUAKING
T1552 2612-2615 NN denotes RNA
T1553 2616-2623 NN denotes binding
T1550 2624-2631 NN denotes protein
T1554 2632-2634 IN denotes in
T1555 2635-2651 NNS denotes oligodendrocytes
T1556 2652-2655 CC denotes and
T1557 2656-2667 NN denotes myelination
T1558 2668-2669 -LRB- denotes [
T1559 2669-2671 CD denotes 33
T1560 2671-2672 -RRB- denotes ]
T1561 2672-2673 . denotes .
T1562 2673-2872 sentence denotes Indeed, the ectopic expression of the QKI-6/7 isoforms in vivo led to the formation of glial cells rather than neurons from neural progenitor, demonstrating its role in cell fate determination [34].
T1563 2674-2680 RB denotes Indeed
T1565 2680-2682 , denotes ,
T1566 2682-2685 DT denotes the
T1568 2686-2693 JJ denotes ectopic
T1567 2694-2704 NN denotes expression
T1569 2705-2707 IN denotes of
T1570 2708-2711 DT denotes the
T1572 2712-2715 NN denotes QKI
T1574 2715-2716 HYPH denotes -
T1575 2716-2717 CD denotes 6
T1576 2717-2718 HYPH denotes /
T1573 2718-2719 CD denotes 7
T1571 2720-2728 NNS denotes isoforms
T1577 2729-2731 FW denotes in
T1578 2732-2736 FW denotes vivo
T1564 2737-2740 VBD denotes led
T1579 2741-2743 IN denotes to
T1580 2744-2747 DT denotes the
T1581 2748-2757 NN denotes formation
T1582 2758-2760 IN denotes of
T1583 2761-2766 JJ denotes glial
T1584 2767-2772 NNS denotes cells
T1585 2773-2779 RB denotes rather
T1586 2780-2784 IN denotes than
T1587 2785-2792 NNS denotes neurons
T1588 2793-2797 IN denotes from
T1589 2798-2804 JJ denotes neural
T1590 2805-2815 NN denotes progenitor
T1591 2815-2817 , denotes ,
T1592 2817-2830 VBG denotes demonstrating
T1593 2831-2834 PRP$ denotes its
T1594 2835-2839 NN denotes role
T1595 2840-2842 IN denotes in
T1596 2843-2847 NN denotes cell
T1598 2848-2852 NN denotes fate
T1597 2853-2866 NN denotes determination
T1599 2867-2868 -LRB- denotes [
T1600 2868-2870 CD denotes 34
T1601 2870-2871 -RRB- denotes ]
T1602 2871-2872 . denotes .
T1603 2872-3109 sentence denotes The loss of GLD-1 protein in Caenorhabditis elegans prevents the appearance of stem cells [35], and the absence of the KH domain protein HOW in Drosophila prevents muscle differentiation and results in flies with held-out-wings [36,37].
T1604 2873-2876 DT denotes The
T1605 2877-2881 NN denotes loss
T1607 2882-2884 IN denotes of
T1608 2885-2888 NN denotes GLD
T1610 2888-2889 HYPH denotes -
T1611 2889-2890 CD denotes 1
T1609 2891-2898 NN denotes protein
T1612 2899-2901 IN denotes in
T1613 2902-2916 NNP denotes Caenorhabditis
T1614 2917-2924 NNP denotes elegans
T1606 2925-2933 VBZ denotes prevents
T1615 2934-2937 DT denotes the
T1616 2938-2948 NN denotes appearance
T1617 2949-2951 IN denotes of
T1618 2952-2956 NN denotes stem
T1619 2957-2962 NNS denotes cells
T1620 2963-2964 -LRB- denotes [
T1621 2964-2966 CD denotes 35
T1622 2966-2967 -RRB- denotes ]
T1623 2967-2969 , denotes ,
T1624 2969-2972 CC denotes and
T1625 2973-2976 DT denotes the
T1626 2977-2984 NN denotes absence
T1628 2985-2987 IN denotes of
T1629 2988-2991 DT denotes the
T1631 2992-2994 NN denotes KH
T1632 2995-3001 NN denotes domain
T1630 3002-3009 NN denotes protein
T1633 3010-3013 NN denotes HOW
T1634 3014-3016 IN denotes in
T1635 3017-3027 NNP denotes Drosophila
T1627 3028-3036 VBZ denotes prevents
T1636 3037-3043 NN denotes muscle
T1637 3044-3059 NN denotes differentiation
T1638 3060-3063 CC denotes and
T1639 3064-3071 VBZ denotes results
T1640 3072-3074 IN denotes in
T1641 3075-3080 NNS denotes flies
T1642 3081-3085 IN denotes with
T1643 3086-3090 VBN denotes held
T1645 3090-3091 HYPH denotes -
T1646 3091-3094 RP denotes out
T1647 3094-3095 HYPH denotes -
T1644 3095-3100 NNS denotes wings
T1648 3101-3102 -LRB- denotes [
T1650 3102-3104 CD denotes 36
T1651 3104-3105 , denotes ,
T1649 3105-3107 CD denotes 37
T1652 3107-3108 -RRB- denotes ]
T1653 3108-3109 . denotes .
T1654 3109-3292 sentence denotes The Src substrate associated in mitosis of 68 kDa (Sam68) is also a member of the family of KH domain RNA binding proteins [38]; however, its physiologic role has remained undefined.
T1655 3110-3113 DT denotes The
T1657 3114-3117 NN denotes Src
T1656 3118-3127 NN denotes substrate
T1659 3128-3138 VBN denotes associated
T1660 3139-3141 IN denotes in
T1661 3142-3149 NN denotes mitosis
T1662 3150-3152 IN denotes of
T1663 3153-3155 CD denotes 68
T1664 3156-3159 NN denotes kDa
T1665 3160-3161 -LRB- denotes (
T1666 3161-3166 NN denotes Sam68
T1667 3166-3167 -RRB- denotes )
T1658 3168-3170 VBZ denotes is
T1669 3171-3175 RB denotes also
T1670 3176-3177 DT denotes a
T1671 3178-3184 NN denotes member
T1672 3185-3187 IN denotes of
T1673 3188-3191 DT denotes the
T1674 3192-3198 NN denotes family
T1675 3199-3201 IN denotes of
T1676 3202-3204 NN denotes KH
T1678 3205-3211 NN denotes domain
T1679 3212-3215 NN denotes RNA
T1680 3216-3223 NN denotes binding
T1677 3224-3232 NN denotes proteins
T1681 3233-3234 -LRB- denotes [
T1682 3234-3236 CD denotes 38
T1683 3236-3237 -RRB- denotes ]
T1684 3237-3238 : denotes ;
T1685 3239-3246 RB denotes however
T1686 3246-3248 , denotes ,
T1687 3248-3251 PRP$ denotes its
T1689 3252-3263 JJ denotes physiologic
T1688 3264-3268 NN denotes role
T1690 3269-3272 VBZ denotes has
T1668 3273-3281 VBN denotes remained
T1691 3282-3291 JJ denotes undefined
T1692 3291-3292 . denotes .
T1693 3292-3471 sentence denotes Sam68 was identified as an SH3 and SH2 domain interacting protein for Src family kinases and is also a known substrate of Src kinases [39–42] and of the breast tumor kinase [43].
T1694 3293-3298 NN denotes Sam68
T1696 3299-3302 VBD denotes was
T1695 3303-3313 VBN denotes identified
T1697 3314-3316 IN denotes as
T1698 3317-3319 DT denotes an
T1700 3320-3323 NN denotes SH3
T1701 3324-3327 CC denotes and
T1702 3328-3331 NN denotes SH2
T1703 3332-3338 NN denotes domain
T1704 3339-3350 VBG denotes interacting
T1699 3351-3358 NN denotes protein
T1705 3359-3362 IN denotes for
T1706 3363-3366 NN denotes Src
T1708 3367-3373 NN denotes family
T1707 3374-3381 NNS denotes kinases
T1709 3382-3385 CC denotes and
T1710 3386-3388 VBZ denotes is
T1711 3389-3393 RB denotes also
T1712 3394-3395 DT denotes a
T1714 3396-3401 JJ denotes known
T1713 3402-3411 NN denotes substrate
T1715 3412-3414 IN denotes of
T1716 3415-3418 NN denotes Src
T1717 3419-3426 NNS denotes kinases
T1718 3427-3428 -LRB- denotes [
T1719 3428-3430 CD denotes 39
T1720 3430-3431 SYM denotes –
T1721 3431-3433 CD denotes 42
T1722 3433-3434 -RRB- denotes ]
T1723 3435-3438 CC denotes and
T1724 3439-3441 IN denotes of
T1725 3442-3445 DT denotes the
T1727 3446-3452 NN denotes breast
T1728 3453-3458 NN denotes tumor
T1726 3459-3465 NN denotes kinase
T1729 3466-3467 -LRB- denotes [
T1730 3467-3469 CD denotes 43
T1731 3469-3470 -RRB- denotes ]
T1732 3470-3471 . denotes .
T1733 3471-3585 sentence denotes Sam68 has been shown to facilitate the export of unspliced HIV RNA [44] and to regulate pre-mRNA processing [45].
T1734 3472-3477 NN denotes Sam68
T1736 3478-3481 VBZ denotes has
T1737 3482-3486 VBN denotes been
T1735 3487-3492 VBN denotes shown
T1738 3493-3495 TO denotes to
T1739 3496-3506 VB denotes facilitate
T1740 3507-3510 DT denotes the
T1741 3511-3517 NN denotes export
T1742 3518-3520 IN denotes of
T1743 3521-3530 JJ denotes unspliced
T1745 3531-3534 NN denotes HIV
T1744 3535-3538 NN denotes RNA
T1746 3539-3540 -LRB- denotes [
T1747 3540-3542 CD denotes 44
T1748 3542-3543 -RRB- denotes ]
T1749 3544-3547 CC denotes and
T1750 3548-3550 TO denotes to
T1751 3551-3559 VB denotes regulate
T1752 3560-3568 NN denotes pre-mRNA
T1753 3569-3579 NN denotes processing
T1754 3580-3581 -LRB- denotes [
T1755 3581-3583 CD denotes 45
T1756 3583-3584 -RRB- denotes ]
T1757 3584-3585 . denotes .
T1758 3585-3691 sentence denotes In the present paper, we report the generation of Sam68−/− mice and analysis of their skeletal phenotype.
T1759 3586-3588 IN denotes In
T1761 3589-3592 DT denotes the
T1763 3593-3600 JJ denotes present
T1762 3601-3606 NN denotes paper
T1764 3606-3608 , denotes ,
T1765 3608-3610 PRP denotes we
T1760 3611-3617 VBP denotes report
T1766 3618-3621 DT denotes the
T1767 3622-3632 NN denotes generation
T1768 3633-3635 IN denotes of
T1769 3636-3641 NN denotes Sam68
T1771 3641-3642 SYM denotes −
T1772 3642-3643 HYPH denotes /
T1773 3643-3644 SYM denotes −
T1770 3645-3649 NNS denotes mice
T1774 3650-3653 CC denotes and
T1775 3654-3662 NN denotes analysis
T1776 3663-3665 IN denotes of
T1777 3666-3671 PRP$ denotes their
T1779 3672-3680 JJ denotes skeletal
T1778 3681-3690 NN denotes phenotype
T1780 3690-3691 . denotes .
T1781 3691-3865 sentence denotes Our data indicate that the absence of Sam68 confers resistance to age-related bone loss in mice such that old Sam68 have a higher bone mass than their wild-type littermates.
T1782 3692-3695 PRP$ denotes Our
T1783 3696-3700 NNS denotes data
T1784 3701-3709 VBP denotes indicate
T1785 3710-3714 IN denotes that
T1787 3715-3718 DT denotes the
T1788 3719-3726 NN denotes absence
T1789 3727-3729 IN denotes of
T1790 3730-3735 NN denotes Sam68
T1786 3736-3743 VBZ denotes confers
T1791 3744-3754 NN denotes resistance
T1792 3755-3757 IN denotes to
T1793 3758-3761 NN denotes age
T1795 3761-3762 HYPH denotes -
T1794 3762-3769 VBN denotes related
T1797 3770-3774 NN denotes bone
T1796 3775-3779 NN denotes loss
T1798 3780-3782 IN denotes in
T1799 3783-3787 NNS denotes mice
T1800 3788-3792 JJ denotes such
T1802 3793-3797 IN denotes that
T1803 3798-3801 JJ denotes old
T1804 3802-3807 NN denotes Sam68
T1801 3808-3812 VBP denotes have
T1805 3813-3814 DT denotes a
T1807 3815-3821 JJR denotes higher
T1808 3822-3826 NN denotes bone
T1806 3827-3831 NN denotes mass
T1809 3832-3836 IN denotes than
T1810 3837-3842 PRP$ denotes their
T1812 3843-3847 JJ denotes wild
T1814 3847-3848 HYPH denotes -
T1813 3848-3852 NN denotes type
T1811 3853-3864 NNS denotes littermates
T1815 3864-3865 . denotes .
T1816 3865-4124 sentence denotes We provide evidence that Sam68 regulates the differentiation of bone marrow stromal cells by showing that cells isolated from Sam68−/− animals had enhanced osteogenic activity and decreased adipogenic activity than those harvested from wild-type littermates.
T1817 3866-3868 PRP denotes We
T1818 3869-3876 VBP denotes provide
T1819 3877-3885 NN denotes evidence
T1820 3886-3890 IN denotes that
T1822 3891-3896 NN denotes Sam68
T1821 3897-3906 VBZ denotes regulates
T1823 3907-3910 DT denotes the
T1824 3911-3926 NN denotes differentiation
T1825 3927-3929 IN denotes of
T1826 3930-3934 NN denotes bone
T1827 3935-3941 NN denotes marrow
T1829 3942-3949 JJ denotes stromal
T1828 3950-3955 NNS denotes cells
T1830 3956-3958 IN denotes by
T1831 3959-3966 VBG denotes showing
T1832 3967-3971 IN denotes that
T1834 3972-3977 NNS denotes cells
T1835 3978-3986 VBN denotes isolated
T1836 3987-3991 IN denotes from
T1837 3992-3997 NN denotes Sam68
T1839 3997-3998 SYM denotes −
T1840 3998-3999 HYPH denotes /
T1841 3999-4000 SYM denotes −
T1838 4001-4008 NNS denotes animals
T1833 4009-4012 VBD denotes had
T1842 4013-4021 VBN denotes enhanced
T1844 4022-4032 JJ denotes osteogenic
T1843 4033-4041 NN denotes activity
T1845 4042-4045 CC denotes and
T1846 4046-4055 VBN denotes decreased
T1848 4056-4066 JJ denotes adipogenic
T1847 4067-4075 NN denotes activity
T1849 4076-4080 IN denotes than
T1850 4081-4086 DT denotes those
T1851 4087-4096 VBN denotes harvested
T1852 4097-4101 IN denotes from
T1853 4102-4106 JJ denotes wild
T1855 4106-4107 HYPH denotes -
T1854 4107-4111 NN denotes type
T1856 4112-4123 NNS denotes littermates
T1857 4123-4124 . denotes .
T1858 4124-4333 sentence denotes Furthermore, Sam68−/− mouse embryo fibroblasts (MEFs) were impaired in their capacity to differentiate into adipocytes, consistent with Sam68 being a regulator of bone marrow mesenchymal cell differentiation.
T1859 4125-4136 RB denotes Furthermore
T1861 4136-4138 , denotes ,
T1862 4138-4143 NN denotes Sam68
T1863 4143-4144 SYM denotes −
T1864 4144-4145 HYPH denotes /
T1865 4145-4146 SYM denotes −
T1866 4147-4152 NN denotes mouse
T1867 4153-4159 NN denotes embryo
T1868 4160-4171 NNS denotes fibroblasts
T1869 4172-4173 -LRB- denotes (
T1870 4173-4177 NNS denotes MEFs
T1871 4177-4178 -RRB- denotes )
T1872 4179-4183 VBD denotes were
T1860 4184-4192 VBN denotes impaired
T1873 4193-4195 IN denotes in
T1874 4196-4201 PRP$ denotes their
T1875 4202-4210 NN denotes capacity
T1876 4211-4213 TO denotes to
T1877 4214-4227 VB denotes differentiate
T1878 4228-4232 IN denotes into
T1879 4233-4243 NNS denotes adipocytes
T1880 4243-4245 , denotes ,
T1881 4245-4255 JJ denotes consistent
T1882 4256-4260 IN denotes with
T1883 4261-4266 NN denotes Sam68
T1884 4267-4272 VBG denotes being
T1885 4273-4274 DT denotes a
T1886 4275-4284 NN denotes regulator
T1887 4285-4287 IN denotes of
T1888 4288-4292 NN denotes bone
T1889 4293-4299 NN denotes marrow
T1891 4300-4311 JJ denotes mesenchymal
T1892 4312-4316 NN denotes cell
T1890 4317-4332 NN denotes differentiation
T1893 4332-4333 . denotes .
T1894 4333-4449 sentence denotes These results also characterize a new animal model to study bone metabolism, regeneration, and repair during aging.
T1895 4334-4339 DT denotes These
T1896 4340-4347 NNS denotes results
T1898 4348-4352 RB denotes also
T1897 4353-4365 VBP denotes characterize
T1899 4366-4367 DT denotes a
T1901 4368-4371 JJ denotes new
T1902 4372-4378 NN denotes animal
T1900 4379-4384 NN denotes model
T1903 4385-4387 TO denotes to
T1904 4388-4393 VB denotes study
T1905 4394-4398 NN denotes bone
T1906 4399-4409 NN denotes metabolism
T1907 4409-4411 , denotes ,
T1908 4411-4423 NN denotes regeneration
T1909 4423-4425 , denotes ,
T1910 4425-4428 CC denotes and
T1911 4429-4435 NN denotes repair
T1912 4436-4442 IN denotes during
T1913 4443-4448 NN denotes aging
T1914 4448-4449 . denotes .
R1000 T1712 T1713 det a,substrate
R1001 T1765 T1760 nsubj we,report
R1002 T1766 T1767 det the,generation
R1003 T1767 T1760 dobj generation,report
R1004 T1768 T1767 prep of,generation
R1005 T1713 T1710 attr substrate,is
R1006 T1769 T1770 nmod Sam68,mice
R1007 T1770 T1768 pobj mice,of
R1008 T1714 T1713 amod known,substrate
R1009 T1771 T1769 punct −,Sam68
R1010 T1772 T1769 punct /,Sam68
R1011 T1773 T1769 punct −,Sam68
R1012 T1774 T1767 cc and,generation
R1013 T1775 T1767 conj analysis,generation
R1014 T1776 T1775 prep of,analysis
R1015 T1777 T1778 poss their,phenotype
R1016 T1715 T1713 prep of,substrate
R1017 T1778 T1776 pobj phenotype,of
R1018 T1779 T1778 amod skeletal,phenotype
R1019 T1780 T1760 punct .,report
R1020 T1716 T1717 compound Src,kinases
R1021 T1782 T1783 poss Our,data
R1022 T1717 T1715 pobj kinases,of
R1023 T1783 T1784 nsubj data,indicate
R1024 T1785 T1786 mark that,confers
R1025 T1718 T1719 punct [,39
R1026 T1786 T1784 ccomp confers,indicate
R1027 T1787 T1788 det the,absence
R1028 T1719 T1717 parataxis 39,kinases
R1029 T1788 T1786 nsubj absence,confers
R1030 T1789 T1788 prep of,absence
R1031 T1790 T1789 pobj Sam68,of
R1032 T1720 T1721 punct –,42
R1033 T1791 T1786 dobj resistance,confers
R1034 T1792 T1791 prep to,resistance
R1035 T1793 T1794 npadvmod age,related
R1036 T1826 T1827 nmod bone,marrow
R1037 T1794 T1796 amod related,loss
R1038 T1795 T1794 punct -,related
R1039 T1796 T1792 pobj loss,to
R1040 T1797 T1796 compound bone,loss
R1041 T1798 T1786 prep in,confers
R1042 T1799 T1798 pobj mice,in
R1043 T1827 T1828 nmod marrow,cells
R1044 T1800 T1801 amod such,have
R1045 T1801 T1786 advcl have,confers
R1046 T1802 T1801 mark that,have
R1047 T1828 T1825 pobj cells,of
R1048 T1803 T1804 amod old,Sam68
R1049 T1804 T1801 nsubj Sam68,have
R1050 T1805 T1806 det a,mass
R1051 T1829 T1828 amod stromal,cells
R1052 T1806 T1801 dobj mass,have
R1053 T1807 T1806 amod higher,mass
R1054 T1808 T1806 compound bone,mass
R1055 T1830 T1818 prep by,provide
R1056 T1809 T1806 prep than,mass
R1057 T1810 T1811 poss their,littermates
R1058 T1811 T1809 pobj littermates,than
R1059 T1831 T1830 pcomp showing,by
R1060 T1812 T1813 amod wild,type
R1061 T1813 T1811 compound type,littermates
R1062 T1814 T1813 punct -,type
R1063 T1815 T1784 punct .,indicate
R1064 T1817 T1818 nsubj We,provide
R1065 T1832 T1833 mark that,had
R1066 T1819 T1818 dobj evidence,provide
R1067 T1820 T1821 mark that,regulates
R1068 T1833 T1831 ccomp had,showing
R1069 T1821 T1819 acl regulates,evidence
R1070 T1822 T1821 nsubj Sam68,regulates
R1071 T1823 T1824 det the,differentiation
R1072 T1834 T1833 nsubj cells,had
R1073 T1824 T1821 dobj differentiation,regulates
R1074 T1825 T1824 prep of,differentiation
R1075 T1835 T1834 acl isolated,cells
R1076 T1836 T1835 prep from,isolated
R1077 T1837 T1838 nmod Sam68,animals
R1078 T1838 T1836 pobj animals,from
R1079 T1839 T1837 punct −,Sam68
R1080 T1840 T1837 punct /,Sam68
R1081 T1841 T1837 punct −,Sam68
R1082 T1842 T1843 amod enhanced,activity
R1083 T1843 T1833 dobj activity,had
R1084 T1844 T1843 amod osteogenic,activity
R1085 T1845 T1843 cc and,activity
R1086 T1846 T1847 amod decreased,activity
R1087 T1847 T1843 conj activity,activity
R1088 T1848 T1847 amod adipogenic,activity
R1089 T1849 T1843 prep than,activity
R1090 T1850 T1849 pobj those,than
R1091 T1851 T1850 acl harvested,those
R1092 T1852 T1851 prep from,harvested
R1093 T1853 T1854 amod wild,type
R1094 T1854 T1856 compound type,littermates
R1095 T1855 T1854 punct -,type
R1096 T1856 T1852 pobj littermates,from
R1097 T1857 T1818 punct .,provide
R1098 T1859 T1860 advmod Furthermore,impaired
R1099 T1861 T1860 punct ", ",impaired
R1100 T1862 T1860 nsubjpass Sam68,impaired
R1101 T1863 T1862 punct −,Sam68
R1102 T1864 T1862 punct /,Sam68
R1103 T1865 T1862 punct −,Sam68
R1104 T1866 T1867 compound mouse,embryo
R1105 T1867 T1868 compound embryo,fibroblasts
R1106 T1868 T1862 appos fibroblasts,Sam68
R1107 T1869 T1868 punct (,fibroblasts
R1108 T1870 T1868 appos MEFs,fibroblasts
R1109 T1871 T1862 punct ),Sam68
R1110 T1872 T1860 auxpass were,impaired
R1111 T1873 T1860 prep in,impaired
R1112 T1874 T1875 poss their,capacity
R1113 T1875 T1873 pobj capacity,in
R1114 T1876 T1877 aux to,differentiate
R1115 T1877 T1875 acl differentiate,capacity
R1116 T1878 T1877 prep into,differentiate
R1117 T1879 T1878 pobj adipocytes,into
R1118 T1880 T1860 punct ", ",impaired
R1119 T1881 T1860 advcl consistent,impaired
R1120 T1882 T1881 prep with,consistent
R1121 T1883 T1884 nsubj Sam68,being
R1122 T1884 T1882 pcomp being,with
R1123 T1885 T1886 det a,regulator
R1124 T1886 T1884 attr regulator,being
R1125 T1887 T1886 prep of,regulator
R1126 T1888 T1889 nmod bone,marrow
R1127 T1889 T1890 nmod marrow,differentiation
R1128 T1890 T1887 pobj differentiation,of
R1129 T1891 T1890 amod mesenchymal,differentiation
R1130 T1892 T1890 compound cell,differentiation
R1131 T1893 T1860 punct .,impaired
R1132 T1895 T1896 det These,results
R1133 T1896 T1897 nsubj results,characterize
R1134 T1898 T1897 advmod also,characterize
R1135 T1899 T1900 det a,model
R1136 T1900 T1897 dobj model,characterize
R1137 T1901 T1900 amod new,model
R1138 T1902 T1900 compound animal,model
R1139 T1903 T1904 aux to,study
R1140 T1904 T1900 advcl study,model
R1141 T1905 T1906 compound bone,metabolism
R1142 T1906 T1904 dobj metabolism,study
R1143 T1907 T1906 punct ", ",metabolism
R1144 T1908 T1906 conj regeneration,metabolism
R1145 T1909 T1908 punct ", ",regeneration
R1146 T1910 T1908 cc and,regeneration
R1147 T1911 T1908 conj repair,regeneration
R1148 T1912 T1904 prep during,study
R1149 T1913 T1912 pobj aging,during
R1150 T1914 T1897 punct .,characterize
R340 T1057 T1058 prep During,favored
R341 T1059 T1060 amod skeletal,development
R342 T1060 T1057 pobj development,During
R343 T1061 T1058 punct ", ",favored
R344 T1062 T1063 det the,activity
R345 T1063 T1058 nsubjpass activity,favored
R346 T1064 T1063 amod anabolic,activity
R347 T1065 T1063 prep of,activity
R348 T1066 T1065 pobj osteoblasts,of
R349 T1067 T1068 punct [,1
R350 T1068 T1063 parataxis 1,activity
R351 T1069 T1068 punct ],1
R352 T1070 T1058 auxpass is,favored
R353 T1071 T1058 prep over,favored
R354 T1072 T1073 det the,activity
R355 T1073 T1071 pobj activity,over
R356 T1074 T1073 amod catabolic,activity
R357 T1075 T1073 prep of,activity
R358 T1076 T1075 pobj osteoclasts,of
R359 T1077 T1078 punct [,2
R360 T1078 T1073 appos 2,activity
R361 T1079 T1078 punct ],2
R362 T1080 T1073 punct ", ",activity
R363 T1081 T1082 dep which,results
R364 T1082 T1073 relcl results,activity
R365 T1083 T1082 prep in,results
R366 T1084 T1085 det a,gain
R367 T1085 T1083 pobj gain,in
R368 T1086 T1085 amod net,gain
R369 T1087 T1085 prep in,gain
R370 T1088 T1089 compound bone,mass
R371 T1089 T1087 pobj mass,in
R372 T1090 T1058 punct .,favored
R373 T1092 T1093 prep At,maintained
R374 T1094 T1095 amod skeletal,maturity
R375 T1095 T1092 pobj maturity,At
R376 T1096 T1093 punct ", ",maintained
R377 T1097 T1098 compound bone,mass
R378 T1098 T1093 nsubjpass mass,maintained
R379 T1099 T1093 auxpass is,maintained
R380 T1100 T1093 prep through,maintained
R381 T1101 T1102 det the,activity
R382 T1102 T1100 pobj activity,through
R383 T1103 T1102 amod balanced,activity
R384 T1104 T1102 prep of,activity
R385 T1105 T1104 pobj osteoblasts,of
R386 T1106 T1105 cc and,osteoblasts
R387 T1107 T1105 conj osteoclasts,osteoblasts
R388 T1108 T1093 prep during,maintained
R389 T1109 T1110 det the,cycle
R390 T1110 T1108 pobj cycle,during
R391 T1111 T1110 compound remodeling,cycle
R392 T1112 T1093 punct .,maintained
R393 T1114 T1115 prep During,is
R394 T1116 T1117 amod skeletal,aging
R395 T1117 T1114 pobj aging,During
R396 T1118 T1115 punct ", ",is
R397 T1119 T1115 expl there,is
R398 T1120 T1121 det a,shift
R399 T1121 T1115 attr shift,is
R400 T1122 T1121 prep in,shift
R401 T1123 T1124 det the,balance
R402 T1124 T1122 pobj balance,in
R403 T1125 T1126 dep that,favors
R404 T1126 T1121 relcl favors,shift
R405 T1127 T1126 dative osteoclast,favors
R406 T1128 T1126 prep over,favors
R407 T1129 T1128 pobj osteoblast,over
R408 T1130 T1126 dobj activity,favors
R409 T1131 T1126 punct ", ",favors
R410 T1132 T1133 dep which,results
R411 T1133 T1126 ccomp results,favors
R412 T1134 T1133 prep in,results
R413 T1135 T1136 amod net,loss
R414 T1136 T1134 pobj loss,in
R415 T1137 T1136 compound bone,loss
R416 T1138 T1139 punct [,3
R417 T1139 T1115 parataxis 3,is
R418 T1140 T1139 punct ],3
R419 T1141 T1115 punct .,is
R420 T1143 T1144 det The,amount
R421 T1144 T1145 nsubjpass amount,determined
R422 T1146 T1144 cc and,amount
R423 T1147 T1144 conj rate,amount
R424 T1148 T1149 prep at,gained
R425 T1149 T1147 relcl gained,rate
R426 T1150 T1148 pobj which,at
R427 T1151 T1149 nsubjpass bone,gained
R428 T1152 T1149 auxpass is,gained
R429 T1153 T1149 prep during,gained
R430 T1154 T1153 pobj development,during
R431 T1155 T1149 cc and,gained
R432 T1156 T1149 conj lost,gained
R433 T1157 T1156 prep during,lost
R434 T1158 T1157 pobj aging,during
R435 T1159 T1145 auxpass are,determined
R436 T1160 T1145 prep in,determined
R437 T1161 T1162 amod large,part
R438 T1162 T1160 pobj part,in
R439 T1163 T1145 prep by,determined
R440 T1164 T1163 pobj genetics,by
R441 T1165 T1166 punct [,4
R442 T1166 T1164 parataxis 4,genetics
R443 T1167 T1168 punct –,6
R444 T1168 T1166 prep 6,4
R445 T1169 T1166 punct ],4
R446 T1170 T1163 cc but,by
R447 T1171 T1170 advmod also,but
R448 T1172 T1163 conj by,by
R449 T1173 T1174 amod physical,activity
R450 T1174 T1172 pobj activity,by
R451 T1175 T1172 cc and,by
R452 T1176 T1172 conj by,by
R453 T1177 T1176 pobj alterations,by
R454 T1178 T1177 prep in,alterations
R455 T1179 T1180 det the,availability
R456 T1180 T1178 pobj availability,in
R457 T1181 T1180 cc and,availability
R458 T1182 T1180 conj response,availability
R459 T1183 T1180 prep of,availability
R460 T1184 T1185 compound bone,cells
R461 T1185 T1183 pobj cells,of
R462 T1186 T1180 prep to,availability
R463 T1187 T1188 amod circulating,hormones
R464 T1188 T1186 pobj hormones,to
R465 T1189 T1190 punct [,7
R466 T1190 T1188 parataxis 7,hormones
R467 T1191 T1192 punct –,9
R468 T1192 T1190 prep 9,7
R469 T1193 T1190 punct ],7
R470 T1194 T1188 cc and,hormones
R471 T1195 T1196 advmod locally,derived
R472 T1196 T1197 amod derived,factors
R473 T1197 T1188 conj factors,hormones
R474 T1198 T1197 compound growth,factors
R475 T1199 T1200 punct [,11
R476 T1200 T1197 parataxis 11,factors
R477 T1201 T1200 nummod 10,11
R478 T1202 T1200 punct ",",11
R479 T1203 T1200 punct ],11
R480 T1204 T1145 punct .,determined
R481 T1206 T1207 mark Whereas,provided
R482 T1207 T1213 advcl provided,known
R483 T1208 T1209 amod genetic,based
R484 T1209 T1211 amod based,studies
R485 T1210 T1209 punct -,based
R486 T1211 T1207 nsubj studies,provided
R487 T1212 T1207 aux have,provided
R488 T1214 T1215 amod novel,insights
R489 T1215 T1207 dobj insights,provided
R490 T1216 T1215 prep into,insights
R491 T1217 T1218 det the,pathways
R492 T1218 T1216 pobj pathways,into
R493 T1219 T1220 dep that,regulate
R494 T1220 T1218 relcl regulate,pathways
R495 T1221 T1222 compound bone,development
R496 T1222 T1220 dobj development,regulate
R497 T1223 T1224 punct [,12
R498 T1224 T1220 parataxis 12,regulate
R499 T1225 T1226 punct –,14
R500 T1226 T1224 prep 14,12
R501 T1227 T1224 punct ],12
R502 T1228 T1213 punct ", ",known
R503 T1229 T1230 advmod relatively,little
R504 T1230 T1213 nsubjpass little,known
R505 T1231 T1213 auxpass is,known
R506 T1232 T1213 prep about,known
R507 T1233 T1234 det the,etiology
R508 T1234 T1232 pobj etiology,about
R509 T1235 T1234 prep of,etiology
R510 T1236 T1237 npadvmod age,related
R511 T1237 T1239 amod related,loss
R512 T1238 T1237 punct -,related
R513 T1239 T1235 pobj loss,of
R514 T1240 T1239 compound bone,loss
R515 T1241 T1213 punct .,known
R516 T1243 T1244 amod Increased,resorption
R517 T1244 T1246 nsubjpass resorption,associated
R518 T1245 T1244 compound bone,resorption
R519 T1247 T1244 prep in,resorption
R520 T1248 T1249 amod elderly,men
R521 T1249 T1247 pobj men,in
R522 T1250 T1249 cc and,men
R523 T1251 T1249 conj women,men
R524 T1252 T1246 auxpass is,associated
R525 T1253 T1246 prep with,associated
R526 T1254 T1255 det a,reduction
R527 T1255 T1253 pobj reduction,with
R528 T1256 T1255 prep in,reduction
R529 T1257 T1258 compound bone,mass
R530 T1258 T1256 pobj mass,in
R531 T1259 T1255 cc and,reduction
R532 T1260 T1261 det an,increase
R533 T1261 T1255 conj increase,reduction
R534 T1262 T1261 prep in,increase
R535 T1263 T1264 amod circulating,levels
R536 T1264 T1262 pobj levels,in
R537 T1265 T1264 prep of,levels
R538 T1266 T1267 compound bone,biomarkers
R539 T1267 T1265 pobj biomarkers,of
R540 T1268 T1269 punct [,15
R541 T1269 T1246 parataxis 15,associated
R542 T1270 T1269 punct ],15
R543 T1271 T1246 punct .,associated
R544 T1273 T1274 det These,changes
R545 T1274 T1275 nsubjpass changes,attributed
R546 T1276 T1275 aux have,attributed
R547 T1277 T1275 auxpass been,attributed
R548 T1278 T1275 advmod primarily,attributed
R549 T1279 T1275 prep to,attributed
R550 T1280 T1281 amod nutritional,deficits
R551 T1281 T1279 pobj deficits,to
R552 T1282 T1281 acl resulting,deficits
R553 T1283 T1282 prep in,resulting
R554 T1284 T1283 pobj alterations,in
R555 T1285 T1284 prep in,alterations
R556 T1286 T1287 det the,axis
R557 T1287 T1285 pobj axis,in
R558 T1288 T1289 nmod parathyroid,hormone
R559 T1289 T1287 nmod hormone,axis
R560 T1290 T1289 punct –,hormone
R561 T1291 T1292 compound vitamin,D
R562 T1292 T1289 appos D,hormone
R563 T1293 T1294 punct [,16
R564 T1294 T1281 parataxis 16,deficits
R565 T1295 T1294 punct ],16
R566 T1296 T1279 punct ", ",to
R567 T1297 T1279 conj to,to
R568 T1298 T1299 amod gonadal,deficiency
R569 T1299 T1297 pobj deficiency,to
R570 T1300 T1299 compound hormone,deficiency
R571 T1301 T1302 punct [,17
R572 T1302 T1299 parataxis 17,deficiency
R573 T1303 T1302 punct ],17
R574 T1304 T1297 punct ", ",to
R575 T1305 T1297 conj to,to
R576 T1306 T1307 compound leptin,levels
R577 T1307 T1305 pobj levels,to
R578 T1308 T1307 cc and,levels
R579 T1309 T1310 det the,system
R580 T1310 T1307 conj system,levels
R581 T1311 T1310 amod sympathetic,system
R582 T1312 T1310 amod nervous,system
R583 T1313 T1314 punct [,8
R584 T1314 T1310 parataxis 8,system
R585 T1315 T1314 punct ",",8
R586 T1316 T1314 appos 18,8
R587 T1317 T1318 punct –,20
R588 T1318 T1316 prep 20,18
R589 T1319 T1314 punct ],8
R590 T1320 T1305 punct ", ",to
R591 T1321 T1305 cc and,to
R592 T1322 T1305 conj to,to
R593 T1323 T1322 pobj alterations,to
R594 T1324 T1323 prep in,alterations
R595 T1325 T1326 compound bone,cell
R596 T1326 T1327 compound cell,apoptosis
R597 T1327 T1324 pobj apoptosis,in
R598 T1328 T1329 punct [,21
R599 T1329 T1323 parataxis 21,alterations
R600 T1330 T1329 punct ],21
R601 T1331 T1275 punct .,attributed
R602 T1333 T1334 compound Bone,loss
R603 T1334 T1335 nsubjpass loss,attributed
R604 T1336 T1334 prep in,loss
R605 T1337 T1338 det the,elderly
R606 T1338 T1336 pobj elderly,in
R607 T1339 T1335 aux has,attributed
R608 T1340 T1335 advmod also,attributed
R609 T1341 T1335 auxpass been,attributed
R610 T1342 T1335 prep to,attributed
R611 T1343 T1342 pobj alterations,to
R612 T1344 T1343 prep in,alterations
R613 T1345 T1346 det the,response
R614 T1346 T1344 pobj response,in
R615 T1347 T1346 prep of,response
R616 T1348 T1349 nmod bone,marrow
R617 T1349 T1350 nmod marrow,cells
R618 T1350 T1347 pobj cells,of
R619 T1351 T1350 amod stromal,cells
R620 T1352 T1346 prep to,response
R621 T1353 T1354 poss their,microenvironment
R622 T1354 T1352 pobj microenvironment,to
R623 T1355 T1356 dep that,favors
R624 T1356 T1346 relcl favors,response
R625 T1357 T1356 dobj differentiation,favors
R626 T1358 T1357 prep down,differentiation
R627 T1359 T1360 det the,lineage
R628 T1360 T1358 pobj lineage,down
R629 T1361 T1360 compound adipocyte,lineage
R630 T1362 T1363 advmod rather,than
R631 T1363 T1360 cc than,lineage
R632 T1364 T1365 det the,lineage
R633 T1365 T1360 conj lineage,lineage
R634 T1366 T1365 compound osteoblast,lineage
R635 T1367 T1368 punct [,22
R636 T1368 T1335 parataxis 22,attributed
R637 T1369 T1368 punct ],22
R638 T1370 T1335 punct .,attributed
R639 T1372 T1373 nsubjpass Aging,associated
R640 T1374 T1373 aux has,associated
R641 T1375 T1373 advmod long,associated
R642 T1376 T1373 auxpass been,associated
R643 T1377 T1373 prep with,associated
R644 T1378 T1379 det an,increase
R645 T1379 T1377 pobj increase,with
R646 T1380 T1379 prep in,increase
R647 T1381 T1382 compound marrow,fat
R648 T1382 T1380 pobj fat,in
R649 T1383 T1382 punct ", ",fat
R650 T1384 T1385 advmod where,favored
R651 T1385 T1382 relcl favored,fat
R652 T1386 T1387 det the,generation
R653 T1387 T1385 nsubjpass generation,favored
R654 T1388 T1387 prep of,generation
R655 T1389 T1388 pobj adipocytes,of
R656 T1390 T1385 auxpass is,favored
R657 T1391 T1385 prep over,favored
R658 T1392 T1391 pobj osteoblasts,over
R659 T1393 T1394 punct [,23
R660 T1394 T1373 parataxis 23,associated
R661 T1395 T1394 punct ],23
R662 T1396 T1373 punct .,associated
R663 T1398 T1399 nsubjpass Osteoblasts,derived
R664 T1400 T1398 cc and,Osteoblasts
R665 T1401 T1398 conj adipocytes,Osteoblasts
R666 T1402 T1399 auxpass are,derived
R667 T1403 T1399 prep from,derived
R668 T1404 T1405 det a,cell
R669 T1405 T1403 pobj cell,from
R670 T1406 T1405 amod common,cell
R671 T1407 T1405 amod mesenchymal,cell
R672 T1408 T1405 compound precursor,cell
R673 T1409 T1405 relcl present,cell
R674 T1410 T1409 prep in,present
R675 T1411 T1412 compound bone,marrow
R676 T1412 T1410 pobj marrow,in
R677 T1413 T1399 punct ", ",derived
R678 T1414 T1399 cc and,derived
R679 T1415 T1416 det the,factors
R680 T1416 T1417 nsubjpass factors,understood
R681 T1417 T1399 conj understood,derived
R682 T1418 T1419 dep that,control
R683 T1419 T1416 relcl control,factors
R684 T1420 T1421 det this,switch
R685 T1421 T1419 dobj switch,control
R686 T1422 T1423 npadvmod age,induced
R687 T1423 T1421 amod induced,switch
R688 T1424 T1423 punct -,induced
R689 T1425 T1421 prep toward,switch
R690 T1426 T1427 amod adipogenic,differentiation
R691 T1427 T1425 pobj differentiation,toward
R692 T1428 T1417 auxpass is,understood
R693 T1429 T1417 neg not,understood
R694 T1430 T1417 advmod well,understood
R695 T1431 T1432 punct [,24
R696 T1432 T1417 parataxis 24,understood
R697 T1433 T1432 punct ],24
R698 T1434 T1417 punct .,understood
R699 T1436 T1437 mark While,associated
R700 T1437 T1444 advcl associated,remains
R701 T1438 T1439 amod several,proteins
R702 T1439 T1437 nsubjpass proteins,associated
R703 T1440 T1439 amod transcriptional,proteins
R704 T1441 T1439 amod regulatory,proteins
R705 T1442 T1437 aux have,associated
R706 T1443 T1437 auxpass been,associated
R707 T1445 T1437 prep with,associated
R708 T1446 T1447 compound cell,determination
R709 T1447 T1445 pobj determination,with
R710 T1448 T1447 compound fate,determination
R711 T1449 T1447 prep of,determination
R712 T1450 T1451 nmod bone,marrow
R713 T1451 T1452 nmod marrow,cells
R714 T1452 T1449 pobj cells,of
R715 T1453 T1452 amod mesenchymal,cells
R716 T1454 T1452 punct ", ",cells
R717 T1455 T1452 prep including,cells
R718 T1456 T1457 nmod peroxisome,receptor
R719 T1457 T1455 pobj receptor,including
R720 T1458 T1459 npadvmod proliferator,activated
R721 T1459 T1457 amod activated,receptor
R722 T1460 T1459 punct –,activated
R723 T1461 T1457 punct γ,receptor
R724 T1462 T1457 punct (,receptor
R725 T1463 T1457 appos PPARγ,receptor
R726 T1464 T1457 punct ),receptor
R727 T1465 T1457 cc and,receptor
R728 T1466 T1457 conj KLF5,receptor
R729 T1467 T1468 punct [,25
R730 T1468 T1437 parataxis 25,associated
R731 T1469 T1470 punct –,30
R732 T1470 T1468 prep 30,25
R733 T1471 T1468 punct ],25
R734 T1472 T1444 punct ", ",remains
R735 T1473 T1474 det the,role
R736 T1474 T1444 nsubj role,remains
R737 T1475 T1474 prep of,role
R738 T1476 T1477 compound RNA,proteins
R739 T1477 T1475 pobj proteins,of
R740 T1478 T1477 compound binding,proteins
R741 T1479 T1474 prep in,role
R742 T1480 T1481 det this,process
R743 T1481 T1479 pobj process,in
R744 T1482 T1444 acomp unknown,remains
R745 T1483 T1444 punct .,remains
R746 T1485 T1486 compound RNA,proteins
R747 T1486 T1488 nsubj proteins,are
R748 T1487 T1486 compound binding,proteins
R749 T1489 T1486 prep of,proteins
R750 T1490 T1491 det the,type
R751 T1491 T1489 pobj type,of
R752 T1492 T1491 compound KH,type
R753 T1493 T1494 amod known,regulators
R754 T1494 T1488 attr regulators,are
R755 T1495 T1494 prep of,regulators
R756 T1496 T1497 amod cellular,differentiation
R757 T1497 T1495 pobj differentiation,of
R758 T1498 T1488 punct .,are
R759 T1500 T1501 prep For,known
R760 T1502 T1500 pobj example,For
R761 T1503 T1501 punct ", ",known
R762 T1504 T1505 compound expression,defects
R763 T1505 T1501 nsubjpass defects,known
R764 T1506 T1505 prep in,defects
R765 T1507 T1508 det the,proteins
R766 T1508 T1506 pobj proteins,in
R767 T1509 T1510 compound KH,domain
R768 T1510 T1508 compound domain,proteins
R769 T1511 T1508 appos NOVA,proteins
R770 T1512 T1511 cc and,NOVA
R771 T1513 T1511 conj FMRP,NOVA
R772 T1514 T1501 auxpass are,known
R773 T1515 T1516 aux to,cause
R774 T1516 T1501 xcomp cause,known
R775 T1517 T1518 amod paraneoplastic,disorders
R776 T1518 T1516 dobj disorders,cause
R777 T1519 T1518 amod neurologic,disorders
R778 T1520 T1521 punct [,31
R779 T1521 T1518 parataxis 31,disorders
R780 T1522 T1521 punct ],31
R781 T1523 T1518 cc and,disorders
R782 T1524 T1525 det the,syndrome
R783 T1525 T1518 conj syndrome,disorders
R784 T1526 T1527 amod fragile,X
R785 T1527 T1525 compound X,syndrome
R786 T1528 T1516 punct ", ",cause
R787 T1529 T1516 advmod respectively,cause
R788 T1530 T1516 punct ", ",cause
R789 T1531 T1516 prep in,cause
R790 T1532 T1531 pobj humans,in
R791 T1533 T1534 punct [,32
R792 T1534 T1516 parataxis 32,cause
R793 T1535 T1534 punct ],32
R794 T1536 T1501 punct .,known
R795 T1538 T1539 det The,phenotype
R796 T1539 T1540 nsubj phenotype,suggests
R797 T1541 T1539 prep of,phenotype
R798 T1542 T1543 det the,mice
R799 T1543 T1541 pobj mice,of
R800 T1544 T1543 nmod quaking,mice
R801 T1545 T1543 amod viable,mice
R802 T1546 T1547 det a,role
R803 T1547 T1540 dobj role,suggests
R804 T1548 T1547 prep for,role
R805 T1549 T1550 det the,protein
R806 T1550 T1548 pobj protein,for
R807 T1551 T1550 compound QUAKING,protein
R808 T1552 T1553 compound RNA,binding
R809 T1553 T1550 compound binding,protein
R810 T1554 T1547 prep in,role
R811 T1555 T1554 pobj oligodendrocytes,in
R812 T1556 T1555 cc and,oligodendrocytes
R813 T1557 T1555 conj myelination,oligodendrocytes
R814 T1558 T1559 punct [,33
R815 T1559 T1540 parataxis 33,suggests
R816 T1560 T1559 punct ],33
R817 T1561 T1540 punct .,suggests
R818 T1563 T1564 advmod Indeed,led
R819 T1565 T1564 punct ", ",led
R820 T1566 T1567 det the,expression
R821 T1567 T1564 nsubj expression,led
R822 T1568 T1567 amod ectopic,expression
R823 T1569 T1567 prep of,expression
R824 T1570 T1571 det the,isoforms
R825 T1571 T1569 pobj isoforms,of
R826 T1572 T1573 nmod QKI,7
R827 T1573 T1571 nummod 7,isoforms
R828 T1574 T1573 punct -,7
R829 T1575 T1573 nummod 6,7
R830 T1576 T1573 punct /,7
R831 T1577 T1578 advmod in,vivo
R832 T1578 T1564 advmod vivo,led
R833 T1579 T1564 prep to,led
R834 T1580 T1581 det the,formation
R835 T1581 T1579 pobj formation,to
R836 T1582 T1581 prep of,formation
R837 T1583 T1584 amod glial,cells
R838 T1584 T1582 pobj cells,of
R839 T1585 T1586 advmod rather,than
R840 T1586 T1584 cc than,cells
R841 T1587 T1584 conj neurons,cells
R842 T1588 T1581 prep from,formation
R843 T1589 T1590 amod neural,progenitor
R844 T1590 T1588 pobj progenitor,from
R845 T1591 T1564 punct ", ",led
R846 T1592 T1564 advcl demonstrating,led
R847 T1593 T1594 poss its,role
R848 T1594 T1592 dobj role,demonstrating
R849 T1595 T1594 prep in,role
R850 T1596 T1597 compound cell,determination
R851 T1597 T1595 pobj determination,in
R852 T1598 T1597 compound fate,determination
R853 T1599 T1600 punct [,34
R854 T1600 T1564 parataxis 34,led
R855 T1601 T1600 punct ],34
R856 T1602 T1564 punct .,led
R857 T1604 T1605 det The,loss
R858 T1605 T1606 nsubj loss,prevents
R859 T1607 T1605 prep of,loss
R860 T1608 T1609 nmod GLD,protein
R861 T1609 T1607 pobj protein,of
R862 T1610 T1608 punct -,GLD
R863 T1611 T1608 nummod 1,GLD
R864 T1612 T1605 prep in,loss
R865 T1613 T1614 compound Caenorhabditis,elegans
R866 T1614 T1612 pobj elegans,in
R867 T1615 T1616 det the,appearance
R868 T1616 T1606 dobj appearance,prevents
R869 T1617 T1616 prep of,appearance
R870 T1618 T1619 compound stem,cells
R871 T1619 T1617 pobj cells,of
R872 T1620 T1621 punct [,35
R873 T1621 T1606 parataxis 35,prevents
R874 T1622 T1621 punct ],35
R875 T1623 T1606 punct ", ",prevents
R876 T1624 T1606 cc and,prevents
R877 T1625 T1626 det the,absence
R878 T1626 T1627 nsubj absence,prevents
R879 T1627 T1606 conj prevents,prevents
R880 T1628 T1626 prep of,absence
R881 T1629 T1630 det the,protein
R882 T1630 T1628 pobj protein,of
R883 T1631 T1630 compound KH,protein
R884 T1632 T1630 compound domain,protein
R885 T1633 T1630 appos HOW,protein
R886 T1634 T1626 prep in,absence
R887 T1635 T1634 pobj Drosophila,in
R888 T1636 T1637 compound muscle,differentiation
R889 T1637 T1627 dobj differentiation,prevents
R890 T1638 T1627 cc and,prevents
R891 T1639 T1627 conj results,prevents
R892 T1640 T1639 prep in,results
R893 T1641 T1640 pobj flies,in
R894 T1642 T1641 prep with,flies
R895 T1643 T1644 amod held,wings
R896 T1644 T1642 pobj wings,with
R897 T1645 T1643 punct -,held
R898 T1646 T1643 prt out,held
R899 T1647 T1644 punct -,wings
R900 T1648 T1649 punct [,37
R901 T1649 T1639 parataxis 37,results
R902 T1650 T1649 nummod 36,37
R903 T1651 T1649 punct ",",37
R904 T1652 T1649 punct ],37
R905 T1653 T1627 punct .,prevents
R906 T1655 T1656 det The,substrate
R907 T1656 T1658 nsubj substrate,is
R908 T1657 T1656 compound Src,substrate
R909 T1658 T1668 ccomp is,remained
R910 T1659 T1656 acl associated,substrate
R911 T1660 T1659 prep in,associated
R912 T1661 T1660 pobj mitosis,in
R913 T1662 T1661 prep of,mitosis
R914 T1663 T1664 nummod 68,kDa
R915 T1664 T1662 pobj kDa,of
R916 T1665 T1666 punct (,Sam68
R917 T1666 T1659 parataxis Sam68,associated
R918 T1667 T1666 punct ),Sam68
R919 T1669 T1658 advmod also,is
R920 T1670 T1671 det a,member
R921 T1671 T1658 attr member,is
R922 T1672 T1671 prep of,member
R923 T1673 T1674 det the,family
R924 T1674 T1672 pobj family,of
R925 T1675 T1674 prep of,family
R926 T1676 T1677 compound KH,proteins
R927 T1677 T1675 pobj proteins,of
R928 T1678 T1677 compound domain,proteins
R929 T1679 T1680 compound RNA,binding
R930 T1680 T1677 compound binding,proteins
R931 T1681 T1682 punct [,38
R932 T1682 T1658 parataxis 38,is
R933 T1683 T1682 punct ],38
R934 T1684 T1668 punct ;,remained
R935 T1685 T1668 advmod however,remained
R936 T1686 T1668 punct ", ",remained
R937 T1687 T1688 poss its,role
R938 T1688 T1668 nsubj role,remained
R939 T1689 T1688 amod physiologic,role
R940 T1690 T1668 aux has,remained
R941 T1691 T1668 acomp undefined,remained
R942 T1692 T1668 punct .,remained
R943 T1721 T1719 prep 42,39
R944 T1694 T1695 nsubjpass Sam68,identified
R945 T1722 T1719 punct ],39
R946 T1723 T1715 cc and,of
R947 T1724 T1715 conj of,of
R948 T1725 T1726 det the,kinase
R949 T1696 T1695 auxpass was,identified
R950 T1726 T1724 pobj kinase,of
R951 T1727 T1728 compound breast,tumor
R952 T1728 T1726 compound tumor,kinase
R953 T1729 T1730 punct [,43
R954 T1697 T1695 prep as,identified
R955 T1730 T1726 parataxis 43,kinase
R956 T1731 T1730 punct ],43
R957 T1698 T1699 det an,protein
R958 T1732 T1695 punct .,identified
R959 T1734 T1735 nsubjpass Sam68,shown
R960 T1736 T1735 aux has,shown
R961 T1737 T1735 auxpass been,shown
R962 T1699 T1697 pobj protein,as
R963 T1738 T1739 aux to,facilitate
R964 T1700 T1699 nmod SH3,protein
R965 T1739 T1735 xcomp facilitate,shown
R966 T1701 T1700 cc and,SH3
R967 T1702 T1700 conj SH2,SH3
R968 T1740 T1741 det the,export
R969 T1703 T1699 nmod domain,protein
R970 T1741 T1739 dobj export,facilitate
R971 T1704 T1699 amod interacting,protein
R972 T1742 T1741 prep of,export
R973 T1743 T1744 amod unspliced,RNA
R974 T1744 T1742 pobj RNA,of
R975 T1705 T1695 prep for,identified
R976 T1745 T1744 compound HIV,RNA
R977 T1746 T1747 punct [,44
R978 T1747 T1739 parataxis 44,facilitate
R979 T1706 T1707 compound Src,kinases
R980 T1748 T1747 punct ],44
R981 T1749 T1739 cc and,facilitate
R982 T1750 T1751 aux to,regulate
R983 T1707 T1705 pobj kinases,for
R984 T1751 T1739 conj regulate,facilitate
R985 T1752 T1753 compound pre-mRNA,processing
R986 T1708 T1707 compound family,kinases
R987 T1753 T1751 dobj processing,regulate
R988 T1754 T1755 punct [,45
R989 T1755 T1751 parataxis 45,regulate
R990 T1709 T1695 cc and,identified
R991 T1756 T1755 punct ],45
R992 T1757 T1735 punct .,shown
R993 T1759 T1760 prep In,report
R994 T1710 T1695 conj is,identified
R995 T1761 T1762 det the,paper
R996 T1711 T1710 advmod also,is
R997 T1762 T1759 pobj paper,In
R998 T1763 T1762 amod present,paper
R999 T1764 T1760 punct ", ",report