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PMC:1315279 / 25253-26386 JSONTXT 5 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T5782 6-8 IN denotes as
T5784 9-12 VBD denotes was
T5783 13-18 VBN denotes shown
T5785 19-23 WRB denotes when
T5787 24-30 NN denotes leptin
T5788 31-34 CC denotes and
T5789 35-38 DT denotes the
T5791 39-50 JJ denotes sympathetic
T5792 51-58 JJ denotes nervous
T5793 59-65 NN denotes system
T5790 66-70 NN denotes axis
T5794 71-75 VBD denotes were
T5786 76-81 VBN denotes shown
T5795 82-84 TO denotes to
T5797 85-95 RB denotes negatively
T5796 96-104 VB denotes regulate
T5798 105-109 NN denotes bone
T5799 110-114 NN denotes mass
T5800 115-116 -LRB- denotes [
T5801 116-117 CD denotes 8
T5802 117-118 -RRB- denotes ]
T5803 118-119 . denotes .
T5804 119-269 sentence denotes To confirm a role for Sam68 in the regulation of adipocyte differentiation, we isolated primary MEFs from 14.5-day-old Sam68+/+ and Sam68−/− embryos.
T5805 120-122 TO denotes To
T5806 123-130 VB denotes confirm
T5808 131-132 DT denotes a
T5809 133-137 NN denotes role
T5810 138-141 IN denotes for
T5811 142-147 NN denotes Sam68
T5812 148-150 IN denotes in
T5813 151-154 DT denotes the
T5814 155-165 NN denotes regulation
T5815 166-168 IN denotes of
T5816 169-178 NN denotes adipocyte
T5817 179-194 NN denotes differentiation
T5818 194-196 , denotes ,
T5819 196-198 PRP denotes we
T5807 199-207 VBD denotes isolated
T5820 208-215 JJ denotes primary
T5821 216-220 NNS denotes MEFs
T5822 221-225 IN denotes from
T5823 226-230 CD denotes 14.5
T5825 230-231 HYPH denotes -
T5824 231-234 NN denotes day
T5827 234-235 HYPH denotes -
T5826 235-238 JJ denotes old
T5829 239-244 NN denotes Sam68
T5830 244-245 SYM denotes +
T5831 245-246 HYPH denotes /
T5832 246-247 SYM denotes +
T5833 248-251 CC denotes and
T5834 252-257 NN denotes Sam68
T5835 257-258 SYM denotes −
T5836 258-259 HYPH denotes /
T5837 259-260 SYM denotes −
T5828 261-268 NNS denotes embryos
T5838 268-269 . denotes .
T5839 269-411 sentence denotes The primary Sam68−/− MEFs were differentiated into adipocytes in vitro in culture medium containing 5 μM pioglitazone to induce adipogenesis.
T5840 270-273 DT denotes The
T5842 274-281 JJ denotes primary
T5843 282-287 NN denotes Sam68
T5844 287-288 SYM denotes −
T5845 288-289 HYPH denotes /
T5846 289-290 SYM denotes −
T5841 291-295 NNS denotes MEFs
T5848 296-300 VBD denotes were
T5847 301-315 VBN denotes differentiated
T5849 316-320 IN denotes into
T5850 321-331 NNS denotes adipocytes
T5851 332-334 FW denotes in
T5852 335-340 FW denotes vitro
T5853 341-343 IN denotes in
T5854 344-351 NN denotes culture
T5855 352-358 NN denotes medium
T5856 359-369 VBG denotes containing
T5857 370-371 CD denotes 5
T5858 372-374 NN denotes μM
T5859 375-387 NN denotes pioglitazone
T5860 388-390 TO denotes to
T5861 391-397 VB denotes induce
T5862 398-410 NN denotes adipogenesis
T5863 410-411 . denotes .
T5864 411-494 sentence denotes Cells at days 0, 4, 6, and 12 were stained with Oil red O to monitor adipogenesis.
T5865 412-417 NNS denotes Cells
T5867 418-420 IN denotes at
T5868 421-425 NNS denotes days
T5869 426-427 CD denotes 0
T5870 427-429 , denotes ,
T5871 429-430 CD denotes 4
T5872 430-432 , denotes ,
T5873 432-433 CD denotes 6
T5874 433-435 , denotes ,
T5875 435-438 CC denotes and
T5876 439-441 CD denotes 12
T5877 442-446 VBD denotes were
T5866 447-454 VBN denotes stained
T5878 455-459 IN denotes with
T5879 460-463 NN denotes Oil
T5881 464-467 NN denotes red
T5880 468-469 NN denotes O
T5882 470-472 TO denotes to
T5883 473-480 VB denotes monitor
T5884 481-493 NN denotes adipogenesis
T5885 493-494 . denotes .
T5886 494-680 sentence denotes Adipogenesis was more pronounced in the wild-type MEFs cultures than in the Sam68−/− MEFs, consistent with the positive role of endogenous Sam68 in adipocyte differentiation (Figure 7).
T5887 495-507 NN denotes Adipogenesis
T5888 508-511 VBD denotes was
T5889 512-516 RBR denotes more
T5890 517-527 JJ denotes pronounced
T5891 528-530 IN denotes in
T5892 531-534 DT denotes the
T5894 535-539 JJ denotes wild
T5896 539-540 HYPH denotes -
T5895 540-544 NN denotes type
T5897 545-549 NNS denotes MEFs
T5893 550-558 NNS denotes cultures
T5898 559-563 IN denotes than
T5899 564-566 IN denotes in
T5900 567-570 DT denotes the
T5902 571-576 NN denotes Sam68
T5903 576-577 SYM denotes −
T5904 577-578 HYPH denotes /
T5905 578-579 SYM denotes −
T5901 580-584 NNS denotes MEFs
T5906 584-586 , denotes ,
T5907 586-596 JJ denotes consistent
T5908 597-601 IN denotes with
T5909 602-605 DT denotes the
T5911 606-614 JJ denotes positive
T5910 615-619 NN denotes role
T5912 620-622 IN denotes of
T5913 623-633 JJ denotes endogenous
T5914 634-639 NN denotes Sam68
T5915 640-642 IN denotes in
T5916 643-652 NN denotes adipocyte
T5917 653-668 NN denotes differentiation
T5918 669-670 -LRB- denotes (
T5919 670-676 NN denotes Figure
T5920 677-678 CD denotes 7
T5921 678-679 -RRB- denotes )
T5922 679-680 . denotes .
T5923 680-901 sentence denotes The expression of key transcription factors including the PPARγ and KLF5 was impaired in Sam68−/− differentiated MEFs compared with Sam68+/+ MEFs, consistent with impaired adipogenesis in the absence of Sam68 (Figure 7).
T5924 681-684 DT denotes The
T5925 685-695 NN denotes expression
T5927 696-698 IN denotes of
T5928 699-702 JJ denotes key
T5930 703-716 NN denotes transcription
T5929 717-724 NNS denotes factors
T5931 725-734 VBG denotes including
T5932 735-738 DT denotes the
T5933 739-744 NN denotes PPARγ
T5934 745-748 CC denotes and
T5935 749-753 NN denotes KLF5
T5936 754-757 VBD denotes was
T5926 758-766 VBN denotes impaired
T5937 767-769 IN denotes in
T5938 770-775 NN denotes Sam68
T5940 775-776 SYM denotes −
T5941 776-777 HYPH denotes /
T5942 777-778 SYM denotes −
T5943 779-793 VBN denotes differentiated
T5939 794-798 NNS denotes MEFs
T5944 799-807 VBN denotes compared
T5945 808-812 IN denotes with
T5946 813-818 NN denotes Sam68
T5948 818-819 SYM denotes +
T5949 819-820 HYPH denotes /
T5950 820-821 SYM denotes +
T5947 822-826 NNS denotes MEFs
T5951 826-828 , denotes ,
T5952 828-838 JJ denotes consistent
T5953 839-843 IN denotes with
T5954 844-852 VBN denotes impaired
T5955 853-865 NN denotes adipogenesis
T5956 866-868 IN denotes in
T5957 869-872 DT denotes the
T5958 873-880 NN denotes absence
T5959 881-883 IN denotes of
T5960 884-889 NN denotes Sam68
T5961 890-891 -LRB- denotes (
T5962 891-897 NN denotes Figure
T5963 898-899 CD denotes 7
T5964 899-900 -RRB- denotes )
T5965 900-901 . denotes .
T5966 901-1109 sentence denotes These data, together with data confirming a lean phenotype in Sam68−/− mice (N. Torabi and S. Richard, unpublished data), support the hypothesis that Sam68 modulates the differentiation of mesenchymal cells.
T5967 902-907 DT denotes These
T5968 908-912 NNS denotes data
T5970 912-914 , denotes ,
T5971 914-922 RB denotes together
T5972 923-927 IN denotes with
T5973 928-932 NNS denotes data
T5974 933-943 VBG denotes confirming
T5975 944-945 DT denotes a
T5977 946-950 JJ denotes lean
T5976 951-960 NN denotes phenotype
T5978 961-963 IN denotes in
T5979 964-969 NN denotes Sam68
T5981 969-970 SYM denotes −
T5982 970-971 HYPH denotes /
T5983 971-972 SYM denotes −
T5980 973-977 NNS denotes mice
T5984 978-979 -LRB- denotes (
T5985 979-981 NNP denotes N.
T5986 982-988 NNP denotes Torabi
T5987 989-992 CC denotes and
T5988 993-995 NNP denotes S.
T5989 996-1003 NNP denotes Richard
T5990 1003-1005 , denotes ,
T5991 1005-1016 JJ denotes unpublished
T5992 1017-1021 NNS denotes data
T5993 1021-1022 -RRB- denotes )
T5994 1022-1024 , denotes ,
T5969 1024-1031 VBP denotes support
T5995 1032-1035 DT denotes the
T5996 1036-1046 NN denotes hypothesis
T5997 1047-1051 IN denotes that
T5999 1052-1057 NN denotes Sam68
T5998 1058-1067 VBZ denotes modulates
T6000 1068-1071 DT denotes the
T6001 1072-1087 NN denotes differentiation
T6002 1088-1090 IN denotes of
T6003 1091-1102 JJ denotes mesenchymal
T6004 1103-1108 NNS denotes cells
T6005 1108-1109 . denotes .
R3463 T5782 T5783 mark as,shown
R3465 T5784 T5783 auxpass was,shown
R3466 T5785 T5786 advmod when,shown
R3467 T5786 T5783 advcl shown,shown
R3468 T5787 T5786 nsubjpass leptin,shown
R3469 T5788 T5787 cc and,leptin
R3470 T5789 T5790 det the,axis
R3471 T5790 T5787 conj axis,leptin
R3472 T5791 T5790 amod sympathetic,axis
R3473 T5792 T5793 amod nervous,system
R3474 T5793 T5790 compound system,axis
R3475 T5794 T5786 auxpass were,shown
R3476 T5795 T5796 aux to,regulate
R3477 T5796 T5786 xcomp regulate,shown
R3478 T5797 T5796 advmod negatively,regulate
R3479 T5798 T5799 compound bone,mass
R3480 T5799 T5796 dobj mass,regulate
R3481 T5800 T5801 punct [,8
R3483 T5802 T5801 punct ],8
R3485 T5805 T5806 aux To,confirm
R3486 T5806 T5807 advcl confirm,isolated
R3487 T5808 T5809 det a,role
R3488 T5809 T5806 dobj role,confirm
R3489 T5810 T5809 prep for,role
R3490 T5811 T5810 pobj Sam68,for
R3491 T5812 T5809 prep in,role
R3492 T5813 T5814 det the,regulation
R3493 T5814 T5812 pobj regulation,in
R3494 T5815 T5814 prep of,regulation
R3495 T5816 T5817 compound adipocyte,differentiation
R3496 T5817 T5815 pobj differentiation,of
R3497 T5818 T5807 punct ", ",isolated
R3498 T5819 T5807 nsubj we,isolated
R3499 T5820 T5821 amod primary,MEFs
R3500 T5821 T5807 dobj MEFs,isolated
R3501 T5822 T5821 prep from,MEFs
R3502 T5823 T5824 nummod 14.5,day
R3503 T5824 T5826 npadvmod day,old
R3504 T5825 T5824 punct -,day
R3505 T5826 T5828 amod old,embryos
R3506 T5827 T5826 punct -,old
R3507 T5828 T5822 pobj embryos,from
R3508 T5829 T5828 nmod Sam68,embryos
R3509 T5830 T5829 punct +,Sam68
R3510 T5831 T5829 punct /,Sam68
R3511 T5832 T5829 punct +,Sam68
R3512 T5833 T5829 cc and,Sam68
R3513 T5834 T5829 conj Sam68,Sam68
R3514 T5835 T5834 punct −,Sam68
R3515 T5836 T5834 punct /,Sam68
R3516 T5837 T5834 punct −,Sam68
R3517 T5838 T5807 punct .,isolated
R3518 T5840 T5841 det The,MEFs
R3519 T5841 T5847 nsubjpass MEFs,differentiated
R3520 T5842 T5841 amod primary,MEFs
R3521 T5843 T5841 nmod Sam68,MEFs
R3522 T5844 T5843 punct −,Sam68
R3523 T5845 T5843 punct /,Sam68
R3524 T5846 T5843 punct −,Sam68
R3525 T5848 T5847 auxpass were,differentiated
R3526 T5849 T5847 prep into,differentiated
R3527 T5850 T5849 pobj adipocytes,into
R3528 T5851 T5852 advmod in,vitro
R3529 T5852 T5847 advmod vitro,differentiated
R3530 T5853 T5847 prep in,differentiated
R3531 T5854 T5855 compound culture,medium
R3532 T5855 T5853 pobj medium,in
R3533 T5856 T5855 acl containing,medium
R3534 T5857 T5858 nummod 5,μM
R3535 T5858 T5859 compound μM,pioglitazone
R3536 T5859 T5856 dobj pioglitazone,containing
R3537 T5860 T5861 aux to,induce
R3538 T5861 T5847 advcl induce,differentiated
R3539 T5862 T5861 dobj adipogenesis,induce
R3540 T5863 T5847 punct .,differentiated
R3541 T5865 T5866 nsubjpass Cells,stained
R3542 T5867 T5865 prep at,Cells
R3543 T5868 T5869 nmod days,0
R3544 T5869 T5867 pobj 0,at
R3545 T5870 T5869 punct ", ",0
R3546 T5871 T5869 conj 4,0
R3547 T5872 T5871 punct ", ",4
R3548 T5873 T5871 conj 6,4
R3549 T5874 T5873 punct ", ",6
R3550 T5875 T5873 cc and,6
R3551 T5876 T5873 conj 12,6
R3552 T5877 T5866 auxpass were,stained
R3553 T5878 T5866 prep with,stained
R3554 T5879 T5880 compound Oil,O
R3555 T5880 T5878 pobj O,with
R3556 T5881 T5880 compound red,O
R3557 T5882 T5883 aux to,monitor
R3558 T5883 T5866 advcl monitor,stained
R3559 T5884 T5883 dobj adipogenesis,monitor
R3560 T5885 T5866 punct .,stained
R3561 T5887 T5888 nsubj Adipogenesis,was
R3562 T5889 T5890 advmod more,pronounced
R3563 T5890 T5888 acomp pronounced,was
R3564 T5891 T5888 prep in,was
R3565 T5892 T5893 det the,cultures
R3566 T5893 T5891 pobj cultures,in
R3567 T5894 T5895 amod wild,type
R3568 T5895 T5893 compound type,cultures
R3569 T5896 T5895 punct -,type
R3570 T5897 T5893 compound MEFs,cultures
R3571 T5898 T5888 prep than,was
R3572 T5899 T5898 prep in,than
R3573 T5900 T5901 det the,MEFs
R3574 T5901 T5899 pobj MEFs,in
R3575 T5902 T5901 nmod Sam68,MEFs
R3576 T5903 T5902 punct −,Sam68
R3577 T5904 T5902 punct /,Sam68
R3578 T5905 T5902 punct −,Sam68
R3579 T5906 T5888 punct ", ",was
R3580 T5907 T5888 advcl consistent,was
R3581 T5908 T5907 prep with,consistent
R3582 T5909 T5910 det the,role
R3583 T5910 T5908 pobj role,with
R3584 T5911 T5910 amod positive,role
R3585 T5912 T5910 prep of,role
R3586 T5913 T5914 amod endogenous,Sam68
R3587 T5914 T5912 pobj Sam68,of
R3588 T5915 T5910 prep in,role
R3589 T5916 T5917 compound adipocyte,differentiation
R3590 T5917 T5915 pobj differentiation,in
R3591 T5918 T5919 punct (,Figure
R3592 T5919 T5888 parataxis Figure,was
R3593 T5920 T5919 nummod 7,Figure
R3594 T5921 T5919 punct ),Figure
R3595 T5922 T5888 punct .,was
R3596 T5924 T5925 det The,expression
R3597 T5925 T5926 nsubjpass expression,impaired
R3598 T5927 T5925 prep of,expression
R3599 T5928 T5929 amod key,factors
R3600 T5929 T5927 pobj factors,of
R3601 T5930 T5929 compound transcription,factors
R3602 T5931 T5929 prep including,factors
R3603 T5932 T5933 det the,PPARγ
R3604 T5933 T5931 pobj PPARγ,including
R3605 T5934 T5933 cc and,PPARγ
R3606 T5935 T5933 conj KLF5,PPARγ
R3607 T5936 T5926 auxpass was,impaired
R3608 T5937 T5926 prep in,impaired
R3609 T5938 T5939 nmod Sam68,MEFs
R3610 T5939 T5937 pobj MEFs,in
R3611 T5940 T5938 punct −,Sam68
R3612 T5941 T5938 punct /,Sam68
R3613 T5942 T5938 punct −,Sam68
R3614 T5943 T5939 amod differentiated,MEFs
R3615 T5944 T5926 prep compared,impaired
R3616 T5945 T5944 prep with,compared
R3617 T5946 T5947 nmod Sam68,MEFs
R3618 T5947 T5945 pobj MEFs,with
R3619 T5948 T5946 punct +,Sam68
R3620 T5949 T5946 punct /,Sam68
R3621 T5950 T5946 punct +,Sam68
R3622 T5951 T5926 punct ", ",impaired
R3623 T5952 T5926 advcl consistent,impaired
R3624 T5953 T5952 prep with,consistent
R3625 T5954 T5955 amod impaired,adipogenesis
R3626 T5955 T5953 pobj adipogenesis,with
R3627 T5956 T5955 prep in,adipogenesis
R3628 T5957 T5958 det the,absence
R3629 T5958 T5956 pobj absence,in
R3630 T5959 T5958 prep of,absence
R3631 T5960 T5959 pobj Sam68,of
R3632 T5961 T5962 punct (,Figure
R3633 T5962 T5926 parataxis Figure,impaired
R3634 T5963 T5962 nummod 7,Figure
R3635 T5964 T5962 punct ),Figure
R3636 T5965 T5926 punct .,impaired
R3637 T5967 T5968 det These,data
R3638 T5968 T5969 nsubj data,support
R3639 T5970 T5968 punct ", ",data
R3640 T5971 T5968 advmod together,data
R3641 T5972 T5971 prep with,together
R3642 T5973 T5972 pobj data,with
R3643 T5974 T5973 acl confirming,data
R3644 T5975 T5976 det a,phenotype
R3645 T5976 T5974 dobj phenotype,confirming
R3646 T5977 T5976 amod lean,phenotype
R3647 T5978 T5976 prep in,phenotype
R3648 T5979 T5980 nmod Sam68,mice
R3649 T5980 T5978 pobj mice,in
R3650 T5981 T5979 punct −,Sam68
R3651 T5982 T5979 punct /,Sam68
R3652 T5983 T5979 punct −,Sam68
R3653 T5984 T5985 punct (,N.
R3654 T5985 T5968 meta N.,data
R3655 T5986 T5985 nmod Torabi,N.
R3656 T5987 T5985 cc and,N.
R3657 T5988 T5985 conj S.,N.
R3658 T5989 T5988 nmod Richard,S.
R3659 T5990 T5988 punct ", ",S.
R3660 T5991 T5992 amod unpublished,data
R3661 T5992 T5988 conj data,S.
R3662 T5993 T5992 punct ),data
R3663 T5994 T5969 punct ", ",support
R3664 T5995 T5996 det the,hypothesis
R3665 T5996 T5969 dobj hypothesis,support
R3666 T5997 T5998 mark that,modulates
R3667 T5998 T5996 acl modulates,hypothesis
R3668 T5999 T5998 nsubj Sam68,modulates
R3669 T6000 T6001 det the,differentiation
R3670 T6001 T5998 dobj differentiation,modulates
R3671 T6002 T6001 prep of,differentiation
R3672 T6003 T6004 amod mesenchymal,cells
R3673 T6004 T6002 pobj cells,of
R3674 T6005 T5969 punct .,support