Id |
Subject |
Object |
Predicate |
Lexical cue |
T5701 |
0-2 |
PRP |
denotes |
It |
T5703 |
3-5 |
VBZ |
denotes |
is |
T5704 |
6-10 |
RB |
denotes |
well |
T5702 |
11-21 |
VBN |
denotes |
recognized |
T5705 |
22-26 |
IN |
denotes |
that |
T5707 |
27-31 |
NN |
denotes |
bone |
T5708 |
32-38 |
NN |
denotes |
marrow |
T5710 |
39-46 |
JJ |
denotes |
stromal |
T5709 |
47-52 |
NNS |
denotes |
cells |
T5706 |
53-57 |
VBP |
denotes |
give |
T5711 |
58-62 |
NN |
denotes |
rise |
T5712 |
63-65 |
IN |
denotes |
to |
T5713 |
66-70 |
DT |
denotes |
both |
T5714 |
71-82 |
NNS |
denotes |
osteoblasts |
T5715 |
83-86 |
CC |
denotes |
and |
T5716 |
87-97 |
NNS |
denotes |
adipocytes |
T5717 |
98-101 |
CC |
denotes |
and |
T5718 |
102-106 |
IN |
denotes |
that |
T5720 |
107-110 |
NN |
denotes |
age |
T5722 |
110-111 |
HYPH |
denotes |
- |
T5721 |
111-118 |
VBN |
denotes |
related |
T5724 |
119-123 |
NN |
denotes |
bone |
T5723 |
124-128 |
NN |
denotes |
loss |
T5725 |
129-131 |
VBZ |
denotes |
is |
T5719 |
132-143 |
VBN |
denotes |
accompanied |
T5726 |
144-146 |
IN |
denotes |
by |
T5727 |
147-149 |
DT |
denotes |
an |
T5728 |
150-158 |
NN |
denotes |
increase |
T5729 |
159-161 |
IN |
denotes |
in |
T5730 |
162-177 |
NN |
denotes |
differentiation |
T5731 |
178-182 |
IN |
denotes |
down |
T5732 |
183-186 |
DT |
denotes |
the |
T5734 |
187-196 |
NN |
denotes |
adipocyte |
T5733 |
197-204 |
NN |
denotes |
lineage |
T5735 |
205-206 |
-LRB- |
denotes |
[ |
T5736 |
206-208 |
CD |
denotes |
22 |
T5737 |
208-209 |
-RRB- |
denotes |
] |
T5738 |
209-210 |
. |
denotes |
. |
T5739 |
210-354 |
sentence |
denotes |
Therefore, the loss of Sam68 could influence the bone marrow stromal cells to differentiate along the osteogenic versus the adipogenic pathway. |
T5740 |
211-220 |
RB |
denotes |
Therefore |
T5742 |
220-222 |
, |
denotes |
, |
T5743 |
222-225 |
DT |
denotes |
the |
T5744 |
226-230 |
NN |
denotes |
loss |
T5745 |
231-233 |
IN |
denotes |
of |
T5746 |
234-239 |
NN |
denotes |
Sam68 |
T5747 |
240-245 |
MD |
denotes |
could |
T5741 |
246-255 |
VB |
denotes |
influence |
T5748 |
256-259 |
DT |
denotes |
the |
T5750 |
260-264 |
NN |
denotes |
bone |
T5751 |
265-271 |
NN |
denotes |
marrow |
T5752 |
272-279 |
JJ |
denotes |
stromal |
T5749 |
280-285 |
NNS |
denotes |
cells |
T5753 |
286-288 |
TO |
denotes |
to |
T5754 |
289-302 |
VB |
denotes |
differentiate |
T5755 |
303-308 |
IN |
denotes |
along |
T5756 |
309-312 |
DT |
denotes |
the |
T5757 |
313-323 |
JJ |
denotes |
osteogenic |
T5758 |
324-330 |
CC |
denotes |
versus |
T5759 |
331-334 |
DT |
denotes |
the |
T5760 |
335-345 |
JJ |
denotes |
adipogenic |
T5761 |
346-353 |
NN |
denotes |
pathway |
T5762 |
353-354 |
. |
denotes |
. |
T5763 |
354-588 |
sentence |
denotes |
Alternatively, the loss of Sam68 could indirectly regulate bone mass as a general disturbance of neuroendocrine control as was shown when leptin and the sympathetic nervous system axis were shown to negatively regulate bone mass [8]. |
T5764 |
355-368 |
RB |
denotes |
Alternatively |
T5766 |
368-370 |
, |
denotes |
, |
T5767 |
370-373 |
DT |
denotes |
the |
T5768 |
374-378 |
NN |
denotes |
loss |
T5769 |
379-381 |
IN |
denotes |
of |
T5770 |
382-387 |
NN |
denotes |
Sam68 |
T5771 |
388-393 |
MD |
denotes |
could |
T5772 |
394-404 |
RB |
denotes |
indirectly |
T5765 |
405-413 |
VB |
denotes |
regulate |
T5773 |
414-418 |
NN |
denotes |
bone |
T5774 |
419-423 |
NN |
denotes |
mass |
T5775 |
424-426 |
IN |
denotes |
as |
T5776 |
427-428 |
DT |
denotes |
a |
T5778 |
429-436 |
JJ |
denotes |
general |
T5777 |
437-448 |
NN |
denotes |
disturbance |
T5779 |
449-451 |
IN |
denotes |
of |
T5780 |
452-466 |
JJ |
denotes |
neuroendocrine |
T5781 |
467-474 |
NN |
denotes |
control |
T5782 |
475-477 |
IN |
denotes |
as |
T5784 |
478-481 |
VBD |
denotes |
was |
T5783 |
482-487 |
VBN |
denotes |
shown |
T5785 |
488-492 |
WRB |
denotes |
when |
T5787 |
493-499 |
NN |
denotes |
leptin |
T5788 |
500-503 |
CC |
denotes |
and |
T5789 |
504-507 |
DT |
denotes |
the |
T5791 |
508-519 |
JJ |
denotes |
sympathetic |
T5792 |
520-527 |
JJ |
denotes |
nervous |
T5793 |
528-534 |
NN |
denotes |
system |
T5790 |
535-539 |
NN |
denotes |
axis |
T5794 |
540-544 |
VBD |
denotes |
were |
T5786 |
545-550 |
VBN |
denotes |
shown |
T5795 |
551-553 |
TO |
denotes |
to |
T5797 |
554-564 |
RB |
denotes |
negatively |
T5796 |
565-573 |
VB |
denotes |
regulate |
T5798 |
574-578 |
NN |
denotes |
bone |
T5799 |
579-583 |
NN |
denotes |
mass |
T5800 |
584-585 |
-LRB- |
denotes |
[ |
T5801 |
585-586 |
CD |
denotes |
8 |
T5802 |
586-587 |
-RRB- |
denotes |
] |
T5803 |
587-588 |
. |
denotes |
. |
T5804 |
588-738 |
sentence |
denotes |
To confirm a role for Sam68 in the regulation of adipocyte differentiation, we isolated primary MEFs from 14.5-day-old Sam68+/+ and Sam68−/− embryos. |
T5805 |
589-591 |
TO |
denotes |
To |
T5806 |
592-599 |
VB |
denotes |
confirm |
T5808 |
600-601 |
DT |
denotes |
a |
T5809 |
602-606 |
NN |
denotes |
role |
T5810 |
607-610 |
IN |
denotes |
for |
T5811 |
611-616 |
NN |
denotes |
Sam68 |
T5812 |
617-619 |
IN |
denotes |
in |
T5813 |
620-623 |
DT |
denotes |
the |
T5814 |
624-634 |
NN |
denotes |
regulation |
T5815 |
635-637 |
IN |
denotes |
of |
T5816 |
638-647 |
NN |
denotes |
adipocyte |
T5817 |
648-663 |
NN |
denotes |
differentiation |
T5818 |
663-665 |
, |
denotes |
, |
T5819 |
665-667 |
PRP |
denotes |
we |
T5807 |
668-676 |
VBD |
denotes |
isolated |
T5820 |
677-684 |
JJ |
denotes |
primary |
T5821 |
685-689 |
NNS |
denotes |
MEFs |
T5822 |
690-694 |
IN |
denotes |
from |
T5823 |
695-699 |
CD |
denotes |
14.5 |
T5825 |
699-700 |
HYPH |
denotes |
- |
T5824 |
700-703 |
NN |
denotes |
day |
T5827 |
703-704 |
HYPH |
denotes |
- |
T5826 |
704-707 |
JJ |
denotes |
old |
T5829 |
708-713 |
NN |
denotes |
Sam68 |
T5830 |
713-714 |
SYM |
denotes |
+ |
T5831 |
714-715 |
HYPH |
denotes |
/ |
T5832 |
715-716 |
SYM |
denotes |
+ |
T5833 |
717-720 |
CC |
denotes |
and |
T5834 |
721-726 |
NN |
denotes |
Sam68 |
T5835 |
726-727 |
SYM |
denotes |
− |
T5836 |
727-728 |
HYPH |
denotes |
/ |
T5837 |
728-729 |
SYM |
denotes |
− |
T5828 |
730-737 |
NNS |
denotes |
embryos |
T5838 |
737-738 |
. |
denotes |
. |
T5839 |
738-880 |
sentence |
denotes |
The primary Sam68−/− MEFs were differentiated into adipocytes in vitro in culture medium containing 5 μM pioglitazone to induce adipogenesis. |
T5840 |
739-742 |
DT |
denotes |
The |
T5842 |
743-750 |
JJ |
denotes |
primary |
T5843 |
751-756 |
NN |
denotes |
Sam68 |
T5844 |
756-757 |
SYM |
denotes |
− |
T5845 |
757-758 |
HYPH |
denotes |
/ |
T5846 |
758-759 |
SYM |
denotes |
− |
T5841 |
760-764 |
NNS |
denotes |
MEFs |
T5848 |
765-769 |
VBD |
denotes |
were |
T5847 |
770-784 |
VBN |
denotes |
differentiated |
T5849 |
785-789 |
IN |
denotes |
into |
T5850 |
790-800 |
NNS |
denotes |
adipocytes |
T5851 |
801-803 |
FW |
denotes |
in |
T5852 |
804-809 |
FW |
denotes |
vitro |
T5853 |
810-812 |
IN |
denotes |
in |
T5854 |
813-820 |
NN |
denotes |
culture |
T5855 |
821-827 |
NN |
denotes |
medium |
T5856 |
828-838 |
VBG |
denotes |
containing |
T5857 |
839-840 |
CD |
denotes |
5 |
T5858 |
841-843 |
NN |
denotes |
μM |
T5859 |
844-856 |
NN |
denotes |
pioglitazone |
T5860 |
857-859 |
TO |
denotes |
to |
T5861 |
860-866 |
VB |
denotes |
induce |
T5862 |
867-879 |
NN |
denotes |
adipogenesis |
T5863 |
879-880 |
. |
denotes |
. |
T5864 |
880-963 |
sentence |
denotes |
Cells at days 0, 4, 6, and 12 were stained with Oil red O to monitor adipogenesis. |
T5865 |
881-886 |
NNS |
denotes |
Cells |
T5867 |
887-889 |
IN |
denotes |
at |
T5868 |
890-894 |
NNS |
denotes |
days |
T5869 |
895-896 |
CD |
denotes |
0 |
T5870 |
896-898 |
, |
denotes |
, |
T5871 |
898-899 |
CD |
denotes |
4 |
T5872 |
899-901 |
, |
denotes |
, |
T5873 |
901-902 |
CD |
denotes |
6 |
T5874 |
902-904 |
, |
denotes |
, |
T5875 |
904-907 |
CC |
denotes |
and |
T5876 |
908-910 |
CD |
denotes |
12 |
T5877 |
911-915 |
VBD |
denotes |
were |
T5866 |
916-923 |
VBN |
denotes |
stained |
T5878 |
924-928 |
IN |
denotes |
with |
T5879 |
929-932 |
NN |
denotes |
Oil |
T5881 |
933-936 |
NN |
denotes |
red |
T5880 |
937-938 |
NN |
denotes |
O |
T5882 |
939-941 |
TO |
denotes |
to |
T5883 |
942-949 |
VB |
denotes |
monitor |
T5884 |
950-962 |
NN |
denotes |
adipogenesis |
T5885 |
962-963 |
. |
denotes |
. |
T5886 |
963-1149 |
sentence |
denotes |
Adipogenesis was more pronounced in the wild-type MEFs cultures than in the Sam68−/− MEFs, consistent with the positive role of endogenous Sam68 in adipocyte differentiation (Figure 7). |
T5887 |
964-976 |
NN |
denotes |
Adipogenesis |
T5888 |
977-980 |
VBD |
denotes |
was |
T5889 |
981-985 |
RBR |
denotes |
more |
T5890 |
986-996 |
JJ |
denotes |
pronounced |
T5891 |
997-999 |
IN |
denotes |
in |
T5892 |
1000-1003 |
DT |
denotes |
the |
T5894 |
1004-1008 |
JJ |
denotes |
wild |
T5896 |
1008-1009 |
HYPH |
denotes |
- |
T5895 |
1009-1013 |
NN |
denotes |
type |
T5897 |
1014-1018 |
NNS |
denotes |
MEFs |
T5893 |
1019-1027 |
NNS |
denotes |
cultures |
T5898 |
1028-1032 |
IN |
denotes |
than |
T5899 |
1033-1035 |
IN |
denotes |
in |
T5900 |
1036-1039 |
DT |
denotes |
the |
T5902 |
1040-1045 |
NN |
denotes |
Sam68 |
T5903 |
1045-1046 |
SYM |
denotes |
− |
T5904 |
1046-1047 |
HYPH |
denotes |
/ |
T5905 |
1047-1048 |
SYM |
denotes |
− |
T5901 |
1049-1053 |
NNS |
denotes |
MEFs |
T5906 |
1053-1055 |
, |
denotes |
, |
T5907 |
1055-1065 |
JJ |
denotes |
consistent |
T5908 |
1066-1070 |
IN |
denotes |
with |
T5909 |
1071-1074 |
DT |
denotes |
the |
T5911 |
1075-1083 |
JJ |
denotes |
positive |
T5910 |
1084-1088 |
NN |
denotes |
role |
T5912 |
1089-1091 |
IN |
denotes |
of |
T5913 |
1092-1102 |
JJ |
denotes |
endogenous |
T5914 |
1103-1108 |
NN |
denotes |
Sam68 |
T5915 |
1109-1111 |
IN |
denotes |
in |
T5916 |
1112-1121 |
NN |
denotes |
adipocyte |
T5917 |
1122-1137 |
NN |
denotes |
differentiation |
T5918 |
1138-1139 |
-LRB- |
denotes |
( |
T5919 |
1139-1145 |
NN |
denotes |
Figure |
T5920 |
1146-1147 |
CD |
denotes |
7 |
T5921 |
1147-1148 |
-RRB- |
denotes |
) |
T5922 |
1148-1149 |
. |
denotes |
. |
T5923 |
1149-1370 |
sentence |
denotes |
The expression of key transcription factors including the PPARγ and KLF5 was impaired in Sam68−/− differentiated MEFs compared with Sam68+/+ MEFs, consistent with impaired adipogenesis in the absence of Sam68 (Figure 7). |
T5924 |
1150-1153 |
DT |
denotes |
The |
T5925 |
1154-1164 |
NN |
denotes |
expression |
T5927 |
1165-1167 |
IN |
denotes |
of |
T5928 |
1168-1171 |
JJ |
denotes |
key |
T5930 |
1172-1185 |
NN |
denotes |
transcription |
T5929 |
1186-1193 |
NNS |
denotes |
factors |
T5931 |
1194-1203 |
VBG |
denotes |
including |
T5932 |
1204-1207 |
DT |
denotes |
the |
T5933 |
1208-1213 |
NN |
denotes |
PPARγ |
T5934 |
1214-1217 |
CC |
denotes |
and |
T5935 |
1218-1222 |
NN |
denotes |
KLF5 |
T5936 |
1223-1226 |
VBD |
denotes |
was |
T5926 |
1227-1235 |
VBN |
denotes |
impaired |
T5937 |
1236-1238 |
IN |
denotes |
in |
T5938 |
1239-1244 |
NN |
denotes |
Sam68 |
T5940 |
1244-1245 |
SYM |
denotes |
− |
T5941 |
1245-1246 |
HYPH |
denotes |
/ |
T5942 |
1246-1247 |
SYM |
denotes |
− |
T5943 |
1248-1262 |
VBN |
denotes |
differentiated |
T5939 |
1263-1267 |
NNS |
denotes |
MEFs |
T5944 |
1268-1276 |
VBN |
denotes |
compared |
T5945 |
1277-1281 |
IN |
denotes |
with |
T5946 |
1282-1287 |
NN |
denotes |
Sam68 |
T5948 |
1287-1288 |
SYM |
denotes |
+ |
T5949 |
1288-1289 |
HYPH |
denotes |
/ |
T5950 |
1289-1290 |
SYM |
denotes |
+ |
T5947 |
1291-1295 |
NNS |
denotes |
MEFs |
T5951 |
1295-1297 |
, |
denotes |
, |
T5952 |
1297-1307 |
JJ |
denotes |
consistent |
T5953 |
1308-1312 |
IN |
denotes |
with |
T5954 |
1313-1321 |
VBN |
denotes |
impaired |
T5955 |
1322-1334 |
NN |
denotes |
adipogenesis |
T5956 |
1335-1337 |
IN |
denotes |
in |
T5957 |
1338-1341 |
DT |
denotes |
the |
T5958 |
1342-1349 |
NN |
denotes |
absence |
T5959 |
1350-1352 |
IN |
denotes |
of |
T5960 |
1353-1358 |
NN |
denotes |
Sam68 |
T5961 |
1359-1360 |
-LRB- |
denotes |
( |
T5962 |
1360-1366 |
NN |
denotes |
Figure |
T5963 |
1367-1368 |
CD |
denotes |
7 |
T5964 |
1368-1369 |
-RRB- |
denotes |
) |
T5965 |
1369-1370 |
. |
denotes |
. |
T5966 |
1370-1578 |
sentence |
denotes |
These data, together with data confirming a lean phenotype in Sam68−/− mice (N. Torabi and S. Richard, unpublished data), support the hypothesis that Sam68 modulates the differentiation of mesenchymal cells. |
T5967 |
1371-1376 |
DT |
denotes |
These |
T5968 |
1377-1381 |
NNS |
denotes |
data |
T5970 |
1381-1383 |
, |
denotes |
, |
T5971 |
1383-1391 |
RB |
denotes |
together |
T5972 |
1392-1396 |
IN |
denotes |
with |
T5973 |
1397-1401 |
NNS |
denotes |
data |
T5974 |
1402-1412 |
VBG |
denotes |
confirming |
T5975 |
1413-1414 |
DT |
denotes |
a |
T5977 |
1415-1419 |
JJ |
denotes |
lean |
T5976 |
1420-1429 |
NN |
denotes |
phenotype |
T5978 |
1430-1432 |
IN |
denotes |
in |
T5979 |
1433-1438 |
NN |
denotes |
Sam68 |
T5981 |
1438-1439 |
SYM |
denotes |
− |
T5982 |
1439-1440 |
HYPH |
denotes |
/ |
T5983 |
1440-1441 |
SYM |
denotes |
− |
T5980 |
1442-1446 |
NNS |
denotes |
mice |
T5984 |
1447-1448 |
-LRB- |
denotes |
( |
T5985 |
1448-1450 |
NNP |
denotes |
N. |
T5986 |
1451-1457 |
NNP |
denotes |
Torabi |
T5987 |
1458-1461 |
CC |
denotes |
and |
T5988 |
1462-1464 |
NNP |
denotes |
S. |
T5989 |
1465-1472 |
NNP |
denotes |
Richard |
T5990 |
1472-1474 |
, |
denotes |
, |
T5991 |
1474-1485 |
JJ |
denotes |
unpublished |
T5992 |
1486-1490 |
NNS |
denotes |
data |
T5993 |
1490-1491 |
-RRB- |
denotes |
) |
T5994 |
1491-1493 |
, |
denotes |
, |
T5969 |
1493-1500 |
VBP |
denotes |
support |
T5995 |
1501-1504 |
DT |
denotes |
the |
T5996 |
1505-1515 |
NN |
denotes |
hypothesis |
T5997 |
1516-1520 |
IN |
denotes |
that |
T5999 |
1521-1526 |
NN |
denotes |
Sam68 |
T5998 |
1527-1536 |
VBZ |
denotes |
modulates |
T6000 |
1537-1540 |
DT |
denotes |
the |
T6001 |
1541-1556 |
NN |
denotes |
differentiation |
T6002 |
1557-1559 |
IN |
denotes |
of |
T6003 |
1560-1571 |
JJ |
denotes |
mesenchymal |
T6004 |
1572-1577 |
NNS |
denotes |
cells |
T6005 |
1577-1578 |
. |
denotes |
. |
R3387 |
T5701 |
T5702 |
nsubjpass |
It,recognized |
R3388 |
T5703 |
T5702 |
auxpass |
is,recognized |
R3389 |
T5704 |
T5702 |
advmod |
well,recognized |
R3390 |
T5705 |
T5706 |
mark |
that,give |
R3391 |
T5706 |
T5702 |
advcl |
give,recognized |
R3392 |
T5707 |
T5708 |
nmod |
bone,marrow |
R3393 |
T5708 |
T5709 |
nmod |
marrow,cells |
R3394 |
T5709 |
T5706 |
nsubj |
cells,give |
R3395 |
T5710 |
T5709 |
amod |
stromal,cells |
R3396 |
T5711 |
T5706 |
dobj |
rise,give |
R3397 |
T5712 |
T5706 |
prep |
to,give |
R3398 |
T5713 |
T5714 |
det |
both,osteoblasts |
R3399 |
T5714 |
T5712 |
pobj |
osteoblasts,to |
R3400 |
T5715 |
T5714 |
cc |
and,osteoblasts |
R3401 |
T5716 |
T5714 |
conj |
adipocytes,osteoblasts |
R3402 |
T5717 |
T5706 |
cc |
and,give |
R3403 |
T5718 |
T5719 |
mark |
that,accompanied |
R3404 |
T5719 |
T5706 |
conj |
accompanied,give |
R3405 |
T5720 |
T5721 |
npadvmod |
age,related |
R3406 |
T5721 |
T5723 |
amod |
related,loss |
R3407 |
T5722 |
T5721 |
punct |
-,related |
R3408 |
T5723 |
T5719 |
nsubjpass |
loss,accompanied |
R3409 |
T5724 |
T5723 |
compound |
bone,loss |
R3410 |
T5725 |
T5719 |
auxpass |
is,accompanied |
R3411 |
T5726 |
T5719 |
agent |
by,accompanied |
R3412 |
T5727 |
T5728 |
det |
an,increase |
R3413 |
T5728 |
T5726 |
pobj |
increase,by |
R3414 |
T5729 |
T5728 |
prep |
in,increase |
R3415 |
T5730 |
T5729 |
pobj |
differentiation,in |
R3416 |
T5731 |
T5719 |
prep |
down,accompanied |
R3417 |
T5732 |
T5733 |
det |
the,lineage |
R3418 |
T5733 |
T5731 |
pobj |
lineage,down |
R3419 |
T5734 |
T5733 |
compound |
adipocyte,lineage |
R3420 |
T5735 |
T5736 |
punct |
[,22 |
R3421 |
T5736 |
T5719 |
parataxis |
22,accompanied |
R3422 |
T5737 |
T5736 |
punct |
],22 |
R3423 |
T5738 |
T5702 |
punct |
.,recognized |
R3424 |
T5740 |
T5741 |
advmod |
Therefore,influence |
R3425 |
T5742 |
T5741 |
punct |
", ",influence |
R3426 |
T5743 |
T5744 |
det |
the,loss |
R3427 |
T5744 |
T5741 |
nsubj |
loss,influence |
R3428 |
T5745 |
T5744 |
prep |
of,loss |
R3429 |
T5746 |
T5745 |
pobj |
Sam68,of |
R3430 |
T5747 |
T5741 |
aux |
could,influence |
R3431 |
T5748 |
T5749 |
det |
the,cells |
R3432 |
T5749 |
T5741 |
dobj |
cells,influence |
R3433 |
T5750 |
T5751 |
nmod |
bone,marrow |
R3434 |
T5751 |
T5749 |
nmod |
marrow,cells |
R3435 |
T5752 |
T5749 |
amod |
stromal,cells |
R3436 |
T5753 |
T5754 |
aux |
to,differentiate |
R3437 |
T5754 |
T5741 |
advcl |
differentiate,influence |
R3438 |
T5755 |
T5754 |
prep |
along,differentiate |
R3439 |
T5756 |
T5757 |
det |
the,osteogenic |
R3440 |
T5757 |
T5755 |
pobj |
osteogenic,along |
R3441 |
T5758 |
T5757 |
cc |
versus,osteogenic |
R3442 |
T5759 |
T5760 |
det |
the,adipogenic |
R3443 |
T5760 |
T5761 |
nmod |
adipogenic,pathway |
R3444 |
T5761 |
T5757 |
conj |
pathway,osteogenic |
R3445 |
T5762 |
T5741 |
punct |
.,influence |
R3446 |
T5764 |
T5765 |
advmod |
Alternatively,regulate |
R3447 |
T5766 |
T5765 |
punct |
", ",regulate |
R3448 |
T5767 |
T5768 |
det |
the,loss |
R3449 |
T5768 |
T5765 |
nsubj |
loss,regulate |
R3450 |
T5769 |
T5768 |
prep |
of,loss |
R3451 |
T5770 |
T5769 |
pobj |
Sam68,of |
R3452 |
T5771 |
T5765 |
aux |
could,regulate |
R3453 |
T5772 |
T5765 |
advmod |
indirectly,regulate |
R3454 |
T5773 |
T5774 |
compound |
bone,mass |
R3455 |
T5774 |
T5765 |
dobj |
mass,regulate |
R3456 |
T5775 |
T5765 |
prep |
as,regulate |
R3457 |
T5776 |
T5777 |
det |
a,disturbance |
R3458 |
T5777 |
T5775 |
pobj |
disturbance,as |
R3459 |
T5778 |
T5777 |
amod |
general,disturbance |
R3460 |
T5779 |
T5777 |
prep |
of,disturbance |
R3461 |
T5780 |
T5781 |
amod |
neuroendocrine,control |
R3462 |
T5781 |
T5779 |
pobj |
control,of |
R3463 |
T5782 |
T5783 |
mark |
as,shown |
R3464 |
T5783 |
T5765 |
advcl |
shown,regulate |
R3465 |
T5784 |
T5783 |
auxpass |
was,shown |
R3466 |
T5785 |
T5786 |
advmod |
when,shown |
R3467 |
T5786 |
T5783 |
advcl |
shown,shown |
R3468 |
T5787 |
T5786 |
nsubjpass |
leptin,shown |
R3469 |
T5788 |
T5787 |
cc |
and,leptin |
R3470 |
T5789 |
T5790 |
det |
the,axis |
R3471 |
T5790 |
T5787 |
conj |
axis,leptin |
R3472 |
T5791 |
T5790 |
amod |
sympathetic,axis |
R3473 |
T5792 |
T5793 |
amod |
nervous,system |
R3474 |
T5793 |
T5790 |
compound |
system,axis |
R3475 |
T5794 |
T5786 |
auxpass |
were,shown |
R3476 |
T5795 |
T5796 |
aux |
to,regulate |
R3477 |
T5796 |
T5786 |
xcomp |
regulate,shown |
R3478 |
T5797 |
T5796 |
advmod |
negatively,regulate |
R3479 |
T5798 |
T5799 |
compound |
bone,mass |
R3480 |
T5799 |
T5796 |
dobj |
mass,regulate |
R3481 |
T5800 |
T5801 |
punct |
[,8 |
R3482 |
T5801 |
T5765 |
parataxis |
8,regulate |
R3483 |
T5802 |
T5801 |
punct |
],8 |
R3484 |
T5803 |
T5765 |
punct |
.,regulate |
R3485 |
T5805 |
T5806 |
aux |
To,confirm |
R3486 |
T5806 |
T5807 |
advcl |
confirm,isolated |
R3487 |
T5808 |
T5809 |
det |
a,role |
R3488 |
T5809 |
T5806 |
dobj |
role,confirm |
R3489 |
T5810 |
T5809 |
prep |
for,role |
R3490 |
T5811 |
T5810 |
pobj |
Sam68,for |
R3491 |
T5812 |
T5809 |
prep |
in,role |
R3492 |
T5813 |
T5814 |
det |
the,regulation |
R3493 |
T5814 |
T5812 |
pobj |
regulation,in |
R3494 |
T5815 |
T5814 |
prep |
of,regulation |
R3495 |
T5816 |
T5817 |
compound |
adipocyte,differentiation |
R3496 |
T5817 |
T5815 |
pobj |
differentiation,of |
R3497 |
T5818 |
T5807 |
punct |
", ",isolated |
R3498 |
T5819 |
T5807 |
nsubj |
we,isolated |
R3499 |
T5820 |
T5821 |
amod |
primary,MEFs |
R3500 |
T5821 |
T5807 |
dobj |
MEFs,isolated |
R3501 |
T5822 |
T5821 |
prep |
from,MEFs |
R3502 |
T5823 |
T5824 |
nummod |
14.5,day |
R3503 |
T5824 |
T5826 |
npadvmod |
day,old |
R3504 |
T5825 |
T5824 |
punct |
-,day |
R3505 |
T5826 |
T5828 |
amod |
old,embryos |
R3506 |
T5827 |
T5826 |
punct |
-,old |
R3507 |
T5828 |
T5822 |
pobj |
embryos,from |
R3508 |
T5829 |
T5828 |
nmod |
Sam68,embryos |
R3509 |
T5830 |
T5829 |
punct |
+,Sam68 |
R3510 |
T5831 |
T5829 |
punct |
/,Sam68 |
R3511 |
T5832 |
T5829 |
punct |
+,Sam68 |
R3512 |
T5833 |
T5829 |
cc |
and,Sam68 |
R3513 |
T5834 |
T5829 |
conj |
Sam68,Sam68 |
R3514 |
T5835 |
T5834 |
punct |
−,Sam68 |
R3515 |
T5836 |
T5834 |
punct |
/,Sam68 |
R3516 |
T5837 |
T5834 |
punct |
−,Sam68 |
R3517 |
T5838 |
T5807 |
punct |
.,isolated |
R3518 |
T5840 |
T5841 |
det |
The,MEFs |
R3519 |
T5841 |
T5847 |
nsubjpass |
MEFs,differentiated |
R3520 |
T5842 |
T5841 |
amod |
primary,MEFs |
R3521 |
T5843 |
T5841 |
nmod |
Sam68,MEFs |
R3522 |
T5844 |
T5843 |
punct |
−,Sam68 |
R3523 |
T5845 |
T5843 |
punct |
/,Sam68 |
R3524 |
T5846 |
T5843 |
punct |
−,Sam68 |
R3525 |
T5848 |
T5847 |
auxpass |
were,differentiated |
R3526 |
T5849 |
T5847 |
prep |
into,differentiated |
R3527 |
T5850 |
T5849 |
pobj |
adipocytes,into |
R3528 |
T5851 |
T5852 |
advmod |
in,vitro |
R3529 |
T5852 |
T5847 |
advmod |
vitro,differentiated |
R3530 |
T5853 |
T5847 |
prep |
in,differentiated |
R3531 |
T5854 |
T5855 |
compound |
culture,medium |
R3532 |
T5855 |
T5853 |
pobj |
medium,in |
R3533 |
T5856 |
T5855 |
acl |
containing,medium |
R3534 |
T5857 |
T5858 |
nummod |
5,μM |
R3535 |
T5858 |
T5859 |
compound |
μM,pioglitazone |
R3536 |
T5859 |
T5856 |
dobj |
pioglitazone,containing |
R3537 |
T5860 |
T5861 |
aux |
to,induce |
R3538 |
T5861 |
T5847 |
advcl |
induce,differentiated |
R3539 |
T5862 |
T5861 |
dobj |
adipogenesis,induce |
R3540 |
T5863 |
T5847 |
punct |
.,differentiated |
R3541 |
T5865 |
T5866 |
nsubjpass |
Cells,stained |
R3542 |
T5867 |
T5865 |
prep |
at,Cells |
R3543 |
T5868 |
T5869 |
nmod |
days,0 |
R3544 |
T5869 |
T5867 |
pobj |
0,at |
R3545 |
T5870 |
T5869 |
punct |
", ",0 |
R3546 |
T5871 |
T5869 |
conj |
4,0 |
R3547 |
T5872 |
T5871 |
punct |
", ",4 |
R3548 |
T5873 |
T5871 |
conj |
6,4 |
R3549 |
T5874 |
T5873 |
punct |
", ",6 |
R3550 |
T5875 |
T5873 |
cc |
and,6 |
R3551 |
T5876 |
T5873 |
conj |
12,6 |
R3552 |
T5877 |
T5866 |
auxpass |
were,stained |
R3553 |
T5878 |
T5866 |
prep |
with,stained |
R3554 |
T5879 |
T5880 |
compound |
Oil,O |
R3555 |
T5880 |
T5878 |
pobj |
O,with |
R3556 |
T5881 |
T5880 |
compound |
red,O |
R3557 |
T5882 |
T5883 |
aux |
to,monitor |
R3558 |
T5883 |
T5866 |
advcl |
monitor,stained |
R3559 |
T5884 |
T5883 |
dobj |
adipogenesis,monitor |
R3560 |
T5885 |
T5866 |
punct |
.,stained |
R3561 |
T5887 |
T5888 |
nsubj |
Adipogenesis,was |
R3562 |
T5889 |
T5890 |
advmod |
more,pronounced |
R3563 |
T5890 |
T5888 |
acomp |
pronounced,was |
R3564 |
T5891 |
T5888 |
prep |
in,was |
R3565 |
T5892 |
T5893 |
det |
the,cultures |
R3566 |
T5893 |
T5891 |
pobj |
cultures,in |
R3567 |
T5894 |
T5895 |
amod |
wild,type |
R3568 |
T5895 |
T5893 |
compound |
type,cultures |
R3569 |
T5896 |
T5895 |
punct |
-,type |
R3570 |
T5897 |
T5893 |
compound |
MEFs,cultures |
R3571 |
T5898 |
T5888 |
prep |
than,was |
R3572 |
T5899 |
T5898 |
prep |
in,than |
R3573 |
T5900 |
T5901 |
det |
the,MEFs |
R3574 |
T5901 |
T5899 |
pobj |
MEFs,in |
R3575 |
T5902 |
T5901 |
nmod |
Sam68,MEFs |
R3576 |
T5903 |
T5902 |
punct |
−,Sam68 |
R3577 |
T5904 |
T5902 |
punct |
/,Sam68 |
R3578 |
T5905 |
T5902 |
punct |
−,Sam68 |
R3579 |
T5906 |
T5888 |
punct |
", ",was |
R3580 |
T5907 |
T5888 |
advcl |
consistent,was |
R3581 |
T5908 |
T5907 |
prep |
with,consistent |
R3582 |
T5909 |
T5910 |
det |
the,role |
R3583 |
T5910 |
T5908 |
pobj |
role,with |
R3584 |
T5911 |
T5910 |
amod |
positive,role |
R3585 |
T5912 |
T5910 |
prep |
of,role |
R3586 |
T5913 |
T5914 |
amod |
endogenous,Sam68 |
R3587 |
T5914 |
T5912 |
pobj |
Sam68,of |
R3588 |
T5915 |
T5910 |
prep |
in,role |
R3589 |
T5916 |
T5917 |
compound |
adipocyte,differentiation |
R3590 |
T5917 |
T5915 |
pobj |
differentiation,in |
R3591 |
T5918 |
T5919 |
punct |
(,Figure |
R3592 |
T5919 |
T5888 |
parataxis |
Figure,was |
R3593 |
T5920 |
T5919 |
nummod |
7,Figure |
R3594 |
T5921 |
T5919 |
punct |
),Figure |
R3595 |
T5922 |
T5888 |
punct |
.,was |
R3596 |
T5924 |
T5925 |
det |
The,expression |
R3597 |
T5925 |
T5926 |
nsubjpass |
expression,impaired |
R3598 |
T5927 |
T5925 |
prep |
of,expression |
R3599 |
T5928 |
T5929 |
amod |
key,factors |
R3600 |
T5929 |
T5927 |
pobj |
factors,of |
R3601 |
T5930 |
T5929 |
compound |
transcription,factors |
R3602 |
T5931 |
T5929 |
prep |
including,factors |
R3603 |
T5932 |
T5933 |
det |
the,PPARγ |
R3604 |
T5933 |
T5931 |
pobj |
PPARγ,including |
R3605 |
T5934 |
T5933 |
cc |
and,PPARγ |
R3606 |
T5935 |
T5933 |
conj |
KLF5,PPARγ |
R3607 |
T5936 |
T5926 |
auxpass |
was,impaired |
R3608 |
T5937 |
T5926 |
prep |
in,impaired |
R3609 |
T5938 |
T5939 |
nmod |
Sam68,MEFs |
R3610 |
T5939 |
T5937 |
pobj |
MEFs,in |
R3611 |
T5940 |
T5938 |
punct |
−,Sam68 |
R3612 |
T5941 |
T5938 |
punct |
/,Sam68 |
R3613 |
T5942 |
T5938 |
punct |
−,Sam68 |
R3614 |
T5943 |
T5939 |
amod |
differentiated,MEFs |
R3615 |
T5944 |
T5926 |
prep |
compared,impaired |
R3616 |
T5945 |
T5944 |
prep |
with,compared |
R3617 |
T5946 |
T5947 |
nmod |
Sam68,MEFs |
R3618 |
T5947 |
T5945 |
pobj |
MEFs,with |
R3619 |
T5948 |
T5946 |
punct |
+,Sam68 |
R3620 |
T5949 |
T5946 |
punct |
/,Sam68 |
R3621 |
T5950 |
T5946 |
punct |
+,Sam68 |
R3622 |
T5951 |
T5926 |
punct |
", ",impaired |
R3623 |
T5952 |
T5926 |
advcl |
consistent,impaired |
R3624 |
T5953 |
T5952 |
prep |
with,consistent |
R3625 |
T5954 |
T5955 |
amod |
impaired,adipogenesis |
R3626 |
T5955 |
T5953 |
pobj |
adipogenesis,with |
R3627 |
T5956 |
T5955 |
prep |
in,adipogenesis |
R3628 |
T5957 |
T5958 |
det |
the,absence |
R3629 |
T5958 |
T5956 |
pobj |
absence,in |
R3630 |
T5959 |
T5958 |
prep |
of,absence |
R3631 |
T5960 |
T5959 |
pobj |
Sam68,of |
R3632 |
T5961 |
T5962 |
punct |
(,Figure |
R3633 |
T5962 |
T5926 |
parataxis |
Figure,impaired |
R3634 |
T5963 |
T5962 |
nummod |
7,Figure |
R3635 |
T5964 |
T5962 |
punct |
),Figure |
R3636 |
T5965 |
T5926 |
punct |
.,impaired |
R3637 |
T5967 |
T5968 |
det |
These,data |
R3638 |
T5968 |
T5969 |
nsubj |
data,support |
R3639 |
T5970 |
T5968 |
punct |
", ",data |
R3640 |
T5971 |
T5968 |
advmod |
together,data |
R3641 |
T5972 |
T5971 |
prep |
with,together |
R3642 |
T5973 |
T5972 |
pobj |
data,with |
R3643 |
T5974 |
T5973 |
acl |
confirming,data |
R3644 |
T5975 |
T5976 |
det |
a,phenotype |
R3645 |
T5976 |
T5974 |
dobj |
phenotype,confirming |
R3646 |
T5977 |
T5976 |
amod |
lean,phenotype |
R3647 |
T5978 |
T5976 |
prep |
in,phenotype |
R3648 |
T5979 |
T5980 |
nmod |
Sam68,mice |
R3649 |
T5980 |
T5978 |
pobj |
mice,in |
R3650 |
T5981 |
T5979 |
punct |
−,Sam68 |
R3651 |
T5982 |
T5979 |
punct |
/,Sam68 |
R3652 |
T5983 |
T5979 |
punct |
−,Sam68 |
R3653 |
T5984 |
T5985 |
punct |
(,N. |
R3654 |
T5985 |
T5968 |
meta |
N.,data |
R3655 |
T5986 |
T5985 |
nmod |
Torabi,N. |
R3656 |
T5987 |
T5985 |
cc |
and,N. |
R3657 |
T5988 |
T5985 |
conj |
S.,N. |
R3658 |
T5989 |
T5988 |
nmod |
Richard,S. |
R3659 |
T5990 |
T5988 |
punct |
", ",S. |
R3660 |
T5991 |
T5992 |
amod |
unpublished,data |
R3661 |
T5992 |
T5988 |
conj |
data,S. |
R3662 |
T5993 |
T5992 |
punct |
),data |
R3663 |
T5994 |
T5969 |
punct |
", ",support |
R3664 |
T5995 |
T5996 |
det |
the,hypothesis |
R3665 |
T5996 |
T5969 |
dobj |
hypothesis,support |
R3666 |
T5997 |
T5998 |
mark |
that,modulates |
R3667 |
T5998 |
T5996 |
acl |
modulates,hypothesis |
R3668 |
T5999 |
T5998 |
nsubj |
Sam68,modulates |
R3669 |
T6000 |
T6001 |
det |
the,differentiation |
R3670 |
T6001 |
T5998 |
dobj |
differentiation,modulates |
R3671 |
T6002 |
T6001 |
prep |
of,differentiation |
R3672 |
T6003 |
T6004 |
amod |
mesenchymal,cells |
R3673 |
T6004 |
T6002 |
pobj |
cells,of |
R3674 |
T6005 |
T5969 |
punct |
.,support |