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PMC:1315279 / 136-1872 JSONTXT 4 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T254 0-3 DT denotes The
T253 0-209 sentence denotes The Src substrate associated in mitosis of 68 kDa (Sam68) is a KH-type RNA binding protein that has been shown to regulate several aspects of RNA metabolism; however, its physiologic role has remained elusive.
T256 4-7 NN denotes Src
T255 8-17 NN denotes substrate
T258 18-28 VBN denotes associated
T259 29-31 IN denotes in
T260 32-39 NN denotes mitosis
T261 40-42 IN denotes of
T262 43-45 CD denotes 68
T263 46-49 NN denotes kDa
T264 50-51 -LRB- denotes (
T265 51-56 NN denotes Sam68
T266 56-57 -RRB- denotes )
T257 58-60 VBZ denotes is
T268 61-62 DT denotes a
T270 63-65 NN denotes KH
T272 65-66 HYPH denotes -
T271 66-70 NN denotes type
T273 71-74 NN denotes RNA
T274 75-82 NN denotes binding
T269 83-90 NN denotes protein
T275 91-95 WDT denotes that
T277 96-99 VBZ denotes has
T278 100-104 VBN denotes been
T276 105-110 VBN denotes shown
T279 111-113 TO denotes to
T280 114-122 VB denotes regulate
T281 123-130 JJ denotes several
T282 131-138 NNS denotes aspects
T283 139-141 IN denotes of
T284 142-145 NN denotes RNA
T285 146-156 NN denotes metabolism
T286 156-157 : denotes ;
T287 158-165 RB denotes however
T288 165-167 , denotes ,
T289 167-170 PRP$ denotes its
T291 171-182 JJ denotes physiologic
T290 183-187 NN denotes role
T292 188-191 VBZ denotes has
T267 192-200 VBN denotes remained
T293 201-208 JJ denotes elusive
T294 208-209 . denotes .
T295 209-289 sentence denotes Herein we report the generation of Sam68-null mice by homologous recombination.
T296 210-216 RB denotes Herein
T298 217-219 PRP denotes we
T297 220-226 VBP denotes report
T299 227-230 DT denotes the
T300 231-241 NN denotes generation
T301 242-244 IN denotes of
T302 245-250 NN denotes Sam68
T304 250-251 HYPH denotes -
T303 251-255 JJ denotes null
T305 256-260 NNS denotes mice
T306 261-263 IN denotes by
T307 264-274 JJ denotes homologous
T308 275-288 NN denotes recombination
T309 288-289 . denotes .
T310 289-451 sentence denotes Aged Sam68−/− mice preserved their bone mass, in sharp contrast with 12-month-old wild-type littermates in which bone mass was decreased up to approximately 75%.
T311 290-294 VBN denotes Aged
T313 295-300 NN denotes Sam68
T314 300-301 SYM denotes −
T315 301-302 HYPH denotes /
T316 302-303 SYM denotes −
T312 304-308 NNS denotes mice
T317 309-318 VBD denotes preserved
T318 319-324 PRP$ denotes their
T320 325-329 NN denotes bone
T319 330-334 NN denotes mass
T321 334-336 , denotes ,
T322 336-338 IN denotes in
T323 339-344 JJ denotes sharp
T324 345-353 NN denotes contrast
T325 354-358 IN denotes with
T326 359-361 CD denotes 12
T328 361-362 HYPH denotes -
T327 362-367 NN denotes month
T330 367-368 HYPH denotes -
T329 368-371 JJ denotes old
T332 372-376 JJ denotes wild
T334 376-377 HYPH denotes -
T333 377-381 NN denotes type
T331 382-393 NNS denotes littermates
T335 394-396 IN denotes in
T337 397-402 WDT denotes which
T338 403-407 NN denotes bone
T339 408-412 NN denotes mass
T340 413-416 VBD denotes was
T336 417-426 VBN denotes decreased
T341 427-429 IN denotes up
T343 430-432 IN denotes to
T344 433-446 RB denotes approximately
T342 447-449 CD denotes 75
T345 449-450 NN denotes %
T346 450-451 . denotes .
T347 451-595 sentence denotes In fact, the bone volume of the 12-month-old Sam68−/− mice was virtually indistinguishable from that of 4-month-old wild-type or Sam68−/− mice.
T348 452-454 IN denotes In
T350 455-459 NN denotes fact
T351 459-461 , denotes ,
T352 461-464 DT denotes the
T354 465-469 NN denotes bone
T353 470-476 NN denotes volume
T355 477-479 IN denotes of
T356 480-483 DT denotes the
T358 484-486 CD denotes 12
T360 486-487 HYPH denotes -
T359 487-492 NN denotes month
T362 492-493 HYPH denotes -
T361 493-496 JJ denotes old
T363 497-502 NN denotes Sam68
T364 502-503 SYM denotes −
T365 503-504 HYPH denotes /
T366 504-505 SYM denotes −
T357 506-510 NNS denotes mice
T349 511-514 VBD denotes was
T367 515-524 RB denotes virtually
T368 525-542 JJ denotes indistinguishable
T369 543-547 IN denotes from
T370 548-552 DT denotes that
T371 553-555 IN denotes of
T372 556-557 CD denotes 4
T374 557-558 HYPH denotes -
T373 558-563 NN denotes month
T376 563-564 HYPH denotes -
T375 564-567 JJ denotes old
T378 568-572 JJ denotes wild
T380 572-573 HYPH denotes -
T379 573-577 NN denotes type
T381 578-580 CC denotes or
T382 581-586 NN denotes Sam68
T383 586-587 SYM denotes −
T384 587-588 HYPH denotes /
T385 588-589 SYM denotes −
T377 590-594 NNS denotes mice
T386 594-595 . denotes .
T387 595-690 sentence denotes Sam68−/− bone marrow stromal cells had a differentiation advantage for the osteogenic pathway.
T388 596-601 NN denotes Sam68
T390 601-602 SYM denotes −
T391 602-603 HYPH denotes /
T392 603-604 SYM denotes −
T393 605-609 NN denotes bone
T394 610-616 NN denotes marrow
T395 617-624 JJ denotes stromal
T389 625-630 NNS denotes cells
T396 631-634 VBD denotes had
T397 635-636 DT denotes a
T399 637-652 NN denotes differentiation
T398 653-662 NN denotes advantage
T400 663-666 IN denotes for
T401 667-670 DT denotes the
T403 671-681 JJ denotes osteogenic
T402 682-689 NN denotes pathway
T404 689-690 . denotes .
T405 690-969 sentence denotes Moreover, the knockdown of Sam68 using short hairpin RNA in the embryonic mesenchymal multipotential progenitor C3H10T1/2 cells resulted in more pronounced expression of the mature osteoblast marker osteocalcin when differentiation was induced with bone morphogenetic protein-2.
T406 691-699 RB denotes Moreover
T408 699-701 , denotes ,
T409 701-704 DT denotes the
T410 705-714 NN denotes knockdown
T411 715-717 IN denotes of
T412 718-723 NN denotes Sam68
T413 724-729 VBG denotes using
T414 730-735 JJ denotes short
T416 736-743 NN denotes hairpin
T415 744-747 NN denotes RNA
T417 748-750 IN denotes in
T418 751-754 DT denotes the
T420 755-764 JJ denotes embryonic
T421 765-776 JJ denotes mesenchymal
T422 777-791 JJ denotes multipotential
T423 792-802 NN denotes progenitor
T424 803-810 NN denotes C3H10T1
T425 810-811 HYPH denotes /
T426 811-812 CD denotes 2
T419 813-818 NNS denotes cells
T407 819-827 VBD denotes resulted
T427 828-830 IN denotes in
T428 831-835 RBR denotes more
T429 836-846 VBN denotes pronounced
T430 847-857 NN denotes expression
T431 858-860 IN denotes of
T432 861-864 DT denotes the
T434 865-871 JJ denotes mature
T435 872-882 NN denotes osteoblast
T433 883-889 NN denotes marker
T436 890-901 NN denotes osteocalcin
T437 902-906 WRB denotes when
T439 907-922 NN denotes differentiation
T440 923-926 VBD denotes was
T438 927-934 VBN denotes induced
T441 935-939 IN denotes with
T442 940-944 NN denotes bone
T444 945-958 JJ denotes morphogenetic
T443 959-966 NN denotes protein
T445 966-967 HYPH denotes -
T446 967-968 CD denotes 2
T447 968-969 . denotes .
T448 969-1237 sentence denotes Cultures of mouse embryo fibroblasts generated from Sam68+/+ and Sam68−/− littermates were induced to differentiate into adipocytes with culture medium containing pioglitazone and the Sam68−/− mouse embryo fibroblasts shown to have impaired adipocyte differentiation.
T449 970-978 NNS denotes Cultures
T451 979-981 IN denotes of
T452 982-987 NN denotes mouse
T453 988-994 NN denotes embryo
T454 995-1006 NNS denotes fibroblasts
T455 1007-1016 VBN denotes generated
T456 1017-1021 IN denotes from
T457 1022-1027 NN denotes Sam68
T459 1027-1028 SYM denotes +
T460 1028-1029 HYPH denotes /
T461 1029-1030 SYM denotes +
T462 1031-1034 CC denotes and
T463 1035-1040 NN denotes Sam68
T464 1040-1041 SYM denotes −
T465 1041-1042 HYPH denotes /
T466 1042-1043 SYM denotes −
T458 1044-1055 NNS denotes littermates
T467 1056-1060 VBD denotes were
T450 1061-1068 VBN denotes induced
T468 1069-1071 TO denotes to
T469 1072-1085 VB denotes differentiate
T470 1086-1090 IN denotes into
T471 1091-1101 NNS denotes adipocytes
T472 1102-1106 IN denotes with
T473 1107-1114 NN denotes culture
T474 1115-1121 NN denotes medium
T475 1122-1132 VBG denotes containing
T476 1133-1145 NN denotes pioglitazone
T477 1146-1149 CC denotes and
T478 1150-1153 DT denotes the
T480 1154-1159 NN denotes Sam68
T481 1159-1160 SYM denotes −
T482 1160-1161 HYPH denotes /
T483 1161-1162 SYM denotes −
T484 1163-1168 NN denotes mouse
T485 1169-1175 NN denotes embryo
T479 1176-1187 NNS denotes fibroblasts
T486 1188-1193 VBN denotes shown
T487 1194-1196 TO denotes to
T488 1197-1201 VB denotes have
T489 1202-1210 VBN denotes impaired
T491 1211-1220 NN denotes adipocyte
T490 1221-1236 NN denotes differentiation
T492 1236-1237 . denotes .
T493 1237-1449 sentence denotes Furthermore, in vivo it was shown that sections of bone from 12-month-old Sam68−/− mice had few marrow adipocytes compared with their age-matched wild-type littermate controls, which exhibited fatty bone marrow.
T494 1238-1249 RB denotes Furthermore
T496 1249-1251 , denotes ,
T497 1251-1253 FW denotes in
T498 1254-1258 FW denotes vivo
T499 1259-1261 PRP denotes it
T500 1262-1265 VBD denotes was
T495 1266-1271 VBN denotes shown
T501 1272-1276 IN denotes that
T503 1277-1285 NNS denotes sections
T504 1286-1288 IN denotes of
T505 1289-1293 NN denotes bone
T506 1294-1298 IN denotes from
T507 1299-1301 CD denotes 12
T509 1301-1302 HYPH denotes -
T508 1302-1307 NN denotes month
T511 1307-1308 HYPH denotes -
T510 1308-1311 JJ denotes old
T513 1312-1317 NN denotes Sam68
T514 1317-1318 SYM denotes −
T515 1318-1319 HYPH denotes /
T516 1319-1320 SYM denotes −
T512 1321-1325 NNS denotes mice
T502 1326-1329 VBD denotes had
T517 1330-1333 JJ denotes few
T519 1334-1340 NN denotes marrow
T518 1341-1351 NNS denotes adipocytes
T520 1352-1360 VBN denotes compared
T521 1361-1365 IN denotes with
T522 1366-1371 PRP$ denotes their
T524 1372-1375 NN denotes age
T526 1375-1376 HYPH denotes -
T525 1376-1383 VBN denotes matched
T527 1384-1388 JJ denotes wild
T529 1388-1389 HYPH denotes -
T528 1389-1393 NN denotes type
T530 1394-1404 NN denotes littermate
T523 1405-1413 NNS denotes controls
T531 1413-1415 , denotes ,
T532 1415-1420 WDT denotes which
T533 1421-1430 VBD denotes exhibited
T534 1431-1436 JJ denotes fatty
T536 1437-1441 NN denotes bone
T535 1442-1448 NN denotes marrow
T537 1448-1449 . denotes .
T538 1449-1736 sentence denotes Our findings identify endogenous Sam68 as a positive regulator of adipocyte differentiation and a negative regulator of osteoblast differentiation, which is consistent with Sam68 being a modulator of bone marrow mesenchymal cell differentiation, and hence bone metabolism, in aged mice.
T539 1450-1453 PRP$ denotes Our
T540 1454-1462 NNS denotes findings
T541 1463-1471 VBP denotes identify
T542 1472-1482 JJ denotes endogenous
T543 1483-1488 NN denotes Sam68
T544 1489-1491 IN denotes as
T545 1492-1493 DT denotes a
T547 1494-1502 JJ denotes positive
T546 1503-1512 NN denotes regulator
T548 1513-1515 IN denotes of
T549 1516-1525 NN denotes adipocyte
T550 1526-1541 NN denotes differentiation
T551 1542-1545 CC denotes and
T552 1546-1547 DT denotes a
T554 1548-1556 JJ denotes negative
T553 1557-1566 NN denotes regulator
T555 1567-1569 IN denotes of
T556 1570-1580 NN denotes osteoblast
T557 1581-1596 NN denotes differentiation
T558 1596-1598 , denotes ,
T559 1598-1603 WDT denotes which
T560 1604-1606 VBZ denotes is
T561 1607-1617 JJ denotes consistent
T562 1618-1622 IN denotes with
T563 1623-1628 NN denotes Sam68
T564 1629-1634 VBG denotes being
T565 1635-1636 DT denotes a
T566 1637-1646 NN denotes modulator
T567 1647-1649 IN denotes of
T568 1650-1654 NN denotes bone
T569 1655-1661 NN denotes marrow
T571 1662-1673 JJ denotes mesenchymal
T572 1674-1678 NN denotes cell
T570 1679-1694 NN denotes differentiation
T573 1694-1696 , denotes ,
T574 1696-1699 CC denotes and
T575 1700-1705 RB denotes hence
T577 1706-1710 NN denotes bone
T576 1711-1721 NN denotes metabolism
T578 1721-1723 , denotes ,
T579 1723-1725 IN denotes in
T580 1726-1730 JJ denotes aged
T581 1731-1735 NNS denotes mice
T582 1735-1736 . denotes .
R100 T341 T342 quantmod up,75
R101 T342 T345 nummod 75,%
R102 T343 T342 quantmod to,75
R103 T344 T342 advmod approximately,75
R104 T345 T336 npadvmod %,decreased
R105 T346 T317 punct .,preserved
R106 T348 T349 prep In,was
R107 T350 T348 pobj fact,In
R108 T351 T349 punct ", ",was
R109 T352 T353 det the,volume
R110 T353 T349 nsubj volume,was
R111 T354 T353 compound bone,volume
R112 T355 T353 prep of,volume
R113 T356 T357 det the,mice
R114 T357 T355 pobj mice,of
R115 T358 T359 nummod 12,month
R116 T359 T361 npadvmod month,old
R117 T360 T359 punct -,month
R118 T361 T357 amod old,mice
R119 T362 T361 punct -,old
R120 T363 T357 nmod Sam68,mice
R121 T364 T363 punct −,Sam68
R122 T365 T363 punct /,Sam68
R123 T366 T363 punct −,Sam68
R124 T367 T368 advmod virtually,indistinguishable
R125 T368 T349 acomp indistinguishable,was
R126 T369 T368 prep from,indistinguishable
R127 T370 T369 pobj that,from
R128 T371 T370 prep of,that
R129 T372 T373 nummod 4,month
R130 T373 T375 npadvmod month,old
R131 T374 T373 punct -,month
R132 T375 T377 amod old,mice
R133 T376 T375 punct -,old
R134 T377 T371 pobj mice,of
R135 T378 T379 amod wild,type
R136 T379 T377 nmod type,mice
R137 T380 T379 punct -,type
R138 T381 T379 cc or,type
R139 T382 T379 conj Sam68,type
R140 T383 T382 punct −,Sam68
R141 T384 T382 punct /,Sam68
R142 T385 T382 punct −,Sam68
R143 T386 T349 punct .,was
R144 T388 T389 nmod Sam68,cells
R145 T389 T396 nsubj cells,had
R146 T390 T388 punct −,Sam68
R147 T391 T388 punct /,Sam68
R148 T392 T388 punct −,Sam68
R149 T393 T394 nmod bone,marrow
R150 T394 T389 nmod marrow,cells
R151 T395 T389 amod stromal,cells
R152 T397 T398 det a,advantage
R153 T398 T396 dobj advantage,had
R154 T399 T398 compound differentiation,advantage
R155 T400 T398 prep for,advantage
R156 T401 T402 det the,pathway
R157 T402 T400 pobj pathway,for
R158 T403 T402 amod osteogenic,pathway
R159 T404 T396 punct .,had
R160 T406 T407 advmod Moreover,resulted
R161 T408 T407 punct ", ",resulted
R162 T409 T410 det the,knockdown
R163 T410 T407 nsubj knockdown,resulted
R164 T411 T410 prep of,knockdown
R165 T412 T411 pobj Sam68,of
R166 T413 T410 acl using,knockdown
R167 T414 T415 amod short,RNA
R168 T415 T413 dobj RNA,using
R169 T416 T415 compound hairpin,RNA
R170 T417 T413 prep in,using
R171 T418 T419 det the,cells
R172 T419 T417 pobj cells,in
R173 T420 T419 amod embryonic,cells
R174 T421 T419 amod mesenchymal,cells
R175 T422 T419 amod multipotential,cells
R176 T423 T419 nmod progenitor,cells
R177 T424 T419 nmod C3H10T1,cells
R178 T425 T424 punct /,C3H10T1
R179 T426 T424 nummod 2,C3H10T1
R18 T254 T255 det The,substrate
R180 T427 T407 prep in,resulted
R181 T428 T429 advmod more,pronounced
R182 T429 T430 amod pronounced,expression
R183 T430 T427 pobj expression,in
R184 T431 T430 prep of,expression
R185 T432 T433 det the,marker
R186 T433 T431 pobj marker,of
R187 T434 T433 amod mature,marker
R188 T435 T433 compound osteoblast,marker
R189 T436 T433 appos osteocalcin,marker
R19 T255 T257 nsubj substrate,is
R190 T437 T438 advmod when,induced
R191 T438 T407 advcl induced,resulted
R192 T439 T438 nsubjpass differentiation,induced
R193 T440 T438 auxpass was,induced
R194 T441 T438 prep with,induced
R195 T442 T443 nmod bone,protein
R196 T443 T441 pobj protein,with
R197 T444 T443 amod morphogenetic,protein
R198 T445 T443 punct -,protein
R199 T446 T443 nummod 2,protein
R20 T256 T255 compound Src,substrate
R200 T447 T407 punct .,resulted
R201 T449 T450 nsubjpass Cultures,induced
R202 T451 T449 prep of,Cultures
R203 T452 T453 compound mouse,embryo
R204 T453 T454 compound embryo,fibroblasts
R205 T454 T451 pobj fibroblasts,of
R206 T455 T449 acl generated,Cultures
R207 T456 T455 prep from,generated
R208 T457 T458 nmod Sam68,littermates
R209 T458 T456 pobj littermates,from
R21 T257 T267 ccomp is,remained
R210 T459 T457 punct +,Sam68
R211 T460 T457 punct /,Sam68
R212 T461 T457 punct +,Sam68
R213 T462 T457 cc and,Sam68
R214 T463 T457 conj Sam68,Sam68
R215 T464 T463 punct −,Sam68
R216 T465 T463 punct /,Sam68
R217 T466 T463 punct −,Sam68
R218 T467 T450 auxpass were,induced
R219 T468 T469 aux to,differentiate
R22 T258 T255 acl associated,substrate
R220 T469 T450 advcl differentiate,induced
R221 T470 T469 prep into,differentiate
R222 T471 T470 pobj adipocytes,into
R223 T472 T450 prep with,induced
R224 T473 T474 compound culture,medium
R225 T474 T472 pobj medium,with
R226 T475 T474 acl containing,medium
R227 T476 T475 dobj pioglitazone,containing
R228 T477 T476 cc and,pioglitazone
R229 T478 T479 det the,fibroblasts
R23 T259 T258 prep in,associated
R230 T479 T476 conj fibroblasts,pioglitazone
R231 T480 T479 nmod Sam68,fibroblasts
R232 T481 T480 punct −,Sam68
R233 T482 T480 punct /,Sam68
R234 T483 T480 punct −,Sam68
R235 T484 T479 compound mouse,fibroblasts
R236 T485 T479 compound embryo,fibroblasts
R237 T486 T479 acl shown,fibroblasts
R238 T487 T488 aux to,have
R239 T488 T486 xcomp have,shown
R24 T260 T259 pobj mitosis,in
R240 T489 T490 amod impaired,differentiation
R241 T490 T488 dobj differentiation,have
R242 T491 T490 compound adipocyte,differentiation
R243 T492 T450 punct .,induced
R244 T494 T495 advmod Furthermore,shown
R245 T496 T495 punct ", ",shown
R246 T497 T498 advmod in,vivo
R247 T498 T495 advmod vivo,shown
R248 T499 T495 nsubjpass it,shown
R249 T500 T495 auxpass was,shown
R25 T261 T260 prep of,mitosis
R250 T501 T502 mark that,had
R251 T502 T495 ccomp had,shown
R252 T503 T502 nsubj sections,had
R253 T504 T503 prep of,sections
R254 T505 T504 pobj bone,of
R255 T506 T503 prep from,sections
R256 T507 T508 nummod 12,month
R257 T508 T510 npadvmod month,old
R258 T509 T508 punct -,month
R259 T510 T512 amod old,mice
R26 T262 T263 nummod 68,kDa
R260 T511 T510 punct -,old
R261 T512 T506 pobj mice,from
R262 T513 T512 nmod Sam68,mice
R263 T514 T513 punct −,Sam68
R264 T515 T513 punct /,Sam68
R265 T516 T513 punct −,Sam68
R266 T517 T518 amod few,adipocytes
R267 T518 T502 dobj adipocytes,had
R268 T519 T518 compound marrow,adipocytes
R269 T520 T502 prep compared,had
R27 T263 T261 pobj kDa,of
R270 T521 T520 prep with,compared
R271 T522 T523 poss their,controls
R272 T523 T521 pobj controls,with
R273 T524 T525 npadvmod age,matched
R274 T525 T523 amod matched,controls
R275 T526 T525 punct -,matched
R276 T527 T528 amod wild,type
R277 T528 T523 compound type,controls
R278 T529 T528 punct -,type
R279 T530 T523 compound littermate,controls
R28 T264 T265 punct (,Sam68
R280 T531 T523 punct ", ",controls
R281 T532 T533 dep which,exhibited
R282 T533 T523 relcl exhibited,controls
R283 T534 T535 amod fatty,marrow
R284 T535 T533 dobj marrow,exhibited
R285 T536 T535 compound bone,marrow
R286 T537 T495 punct .,shown
R287 T539 T540 poss Our,findings
R289 T540 T541 nsubj findings,identify
R29 T265 T255 parataxis Sam68,substrate
R290 T542 T543 amod endogenous,Sam68
R291 T543 T541 dobj Sam68,identify
R292 T544 T541 prep as,identify
R293 T545 T546 det a,regulator
R294 T546 T544 pobj regulator,as
R295 T547 T546 amod positive,regulator
R296 T548 T546 prep of,regulator
R297 T549 T550 compound adipocyte,differentiation
R298 T550 T548 pobj differentiation,of
R299 T551 T546 cc and,regulator
R30 T266 T265 punct ),Sam68
R300 T552 T553 det a,regulator
R301 T553 T546 conj regulator,regulator
R302 T554 T553 amod negative,regulator
R303 T555 T553 prep of,regulator
R304 T556 T557 compound osteoblast,differentiation
R305 T557 T555 pobj differentiation,of
R306 T558 T541 punct ", ",identify
R307 T559 T560 dep which,is
R308 T560 T541 advcl is,identify
R309 T561 T560 acomp consistent,is
R31 T268 T269 det a,protein
R310 T562 T561 prep with,consistent
R311 T563 T564 nsubj Sam68,being
R312 T564 T562 pcomp being,with
R313 T565 T566 det a,modulator
R314 T566 T564 attr modulator,being
R315 T567 T566 prep of,modulator
R316 T568 T569 nmod bone,marrow
R317 T569 T570 nmod marrow,differentiation
R318 T570 T567 pobj differentiation,of
R319 T571 T572 amod mesenchymal,cell
R32 T269 T257 attr protein,is
R320 T572 T570 compound cell,differentiation
R321 T573 T570 punct ", ",differentiation
R322 T574 T570 cc and,differentiation
R323 T575 T576 advmod hence,metabolism
R324 T576 T570 conj metabolism,differentiation
R325 T577 T576 compound bone,metabolism
R326 T578 T564 punct ", ",being
R327 T579 T564 prep in,being
R328 T580 T581 amod aged,mice
R329 T581 T579 pobj mice,in
R33 T270 T271 compound KH,type
R330 T582 T541 punct .,identify
R34 T271 T269 compound type,protein
R35 T272 T271 punct -,type
R36 T273 T274 compound RNA,binding
R37 T274 T269 compound binding,protein
R38 T275 T276 dep that,shown
R39 T276 T269 relcl shown,protein
R40 T277 T276 aux has,shown
R41 T278 T276 auxpass been,shown
R42 T279 T280 aux to,regulate
R43 T280 T276 xcomp regulate,shown
R44 T281 T282 amod several,aspects
R45 T282 T280 dobj aspects,regulate
R46 T283 T282 prep of,aspects
R47 T284 T285 compound RNA,metabolism
R48 T285 T283 pobj metabolism,of
R49 T286 T267 punct ;,remained
R50 T287 T267 advmod however,remained
R51 T288 T267 punct ", ",remained
R52 T289 T290 poss its,role
R53 T290 T267 nsubj role,remained
R54 T291 T290 amod physiologic,role
R55 T292 T267 aux has,remained
R56 T293 T267 acomp elusive,remained
R57 T294 T267 punct .,remained
R58 T296 T297 advmod Herein,report
R59 T298 T297 nsubj we,report
R60 T299 T300 det the,generation
R61 T300 T297 dobj generation,report
R62 T301 T300 prep of,generation
R63 T302 T303 npadvmod Sam68,null
R64 T303 T305 amod null,mice
R65 T304 T303 punct -,null
R66 T305 T301 pobj mice,of
R67 T306 T300 prep by,generation
R68 T307 T308 amod homologous,recombination
R69 T308 T306 pobj recombination,by
R70 T309 T297 punct .,report
R71 T311 T312 amod Aged,mice
R72 T312 T317 nsubj mice,preserved
R73 T313 T312 nmod Sam68,mice
R74 T314 T313 punct −,Sam68
R75 T315 T313 punct /,Sam68
R76 T316 T313 punct −,Sam68
R77 T318 T319 poss their,mass
R78 T319 T317 dobj mass,preserved
R79 T320 T319 compound bone,mass
R80 T321 T317 punct ", ",preserved
R81 T322 T317 prep in,preserved
R82 T323 T324 amod sharp,contrast
R83 T324 T322 pobj contrast,in
R84 T325 T324 prep with,contrast
R85 T326 T327 nummod 12,month
R86 T327 T329 npadvmod month,old
R87 T328 T327 punct -,month
R88 T329 T331 amod old,littermates
R89 T330 T329 punct -,old
R90 T331 T325 pobj littermates,with
R91 T332 T333 amod wild,type
R92 T333 T331 compound type,littermates
R93 T334 T333 punct -,type
R94 T335 T336 prep in,decreased
R95 T336 T331 relcl decreased,littermates
R96 T337 T335 pobj which,in
R97 T338 T339 compound bone,mass
R98 T339 T336 nsubjpass mass,decreased
R99 T340 T336 auxpass was,decreased