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PMC:1315279 / 12920-16373 JSONTXT 5 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T3035 0-5 NN denotes Sam68
T3036 6-16 NN denotes Deficiency
T3037 17-25 VBZ denotes Protects
T3038 26-30 NNS denotes Mice
T3039 31-35 IN denotes from
T3040 36-39 NN denotes Age
T3042 39-40 HYPH denotes -
T3041 40-47 VBN denotes Related
T3044 48-52 NN denotes Bone
T3043 53-57 NN denotes Loss
T3045 57-226 sentence denotes Src null animals are known to have bone metabolism defects [48], and since Sam68 is a substrate of Src, we decided to analyze the Sam68 mice for skeletal abnormalities.
T3046 58-61 NN denotes Src
T3048 62-66 JJ denotes null
T3047 67-74 NNS denotes animals
T3050 75-78 VBP denotes are
T3049 79-84 VBN denotes known
T3051 85-87 TO denotes to
T3052 88-92 VB denotes have
T3053 93-97 NN denotes bone
T3054 98-108 NN denotes metabolism
T3055 109-116 NNS denotes defects
T3056 117-118 -LRB- denotes [
T3057 118-120 CD denotes 48
T3058 120-121 -RRB- denotes ]
T3059 121-123 , denotes ,
T3060 123-126 CC denotes and
T3061 127-132 IN denotes since
T3063 133-138 NN denotes Sam68
T3062 139-141 VBZ denotes is
T3065 142-143 DT denotes a
T3066 144-153 NN denotes substrate
T3067 154-156 IN denotes of
T3068 157-160 NN denotes Src
T3069 160-162 , denotes ,
T3070 162-164 PRP denotes we
T3064 165-172 VBD denotes decided
T3071 173-175 TO denotes to
T3072 176-183 VB denotes analyze
T3073 184-187 DT denotes the
T3075 188-193 NN denotes Sam68
T3074 194-198 NNS denotes mice
T3076 199-202 IN denotes for
T3077 203-211 JJ denotes skeletal
T3078 212-225 NNS denotes abnormalities
T3079 225-226 . denotes .
T3080 226-332 sentence denotes Cohorts of Sam68+/+ and Sam68−/− mice were euthanized at 4 and 12 months of age for skeletal phenotyping.
T3081 227-234 NNS denotes Cohorts
T3083 235-237 IN denotes of
T3084 238-243 NN denotes Sam68
T3086 243-244 SYM denotes +
T3087 244-245 HYPH denotes /
T3088 245-246 SYM denotes +
T3089 247-250 CC denotes and
T3090 251-256 NN denotes Sam68
T3091 256-257 SYM denotes −
T3092 257-258 HYPH denotes /
T3093 258-259 SYM denotes −
T3085 260-264 NNS denotes mice
T3094 265-269 VBD denotes were
T3082 270-280 VBN denotes euthanized
T3095 281-283 IN denotes at
T3096 284-285 CD denotes 4
T3098 286-289 CC denotes and
T3099 290-292 CD denotes 12
T3097 293-299 NNS denotes months
T3100 300-302 IN denotes of
T3101 303-306 NN denotes age
T3102 307-310 IN denotes for
T3103 311-319 JJ denotes skeletal
T3104 320-331 NN denotes phenotyping
T3105 331-332 . denotes .
T3106 332-494 sentence denotes To minimize differences in the bone phenotype that might arise secondary to gender or weight differences, we selected age-matched female mice for these analyses.
T3107 333-335 TO denotes To
T3108 336-344 VB denotes minimize
T3110 345-356 NNS denotes differences
T3111 357-359 IN denotes in
T3112 360-363 DT denotes the
T3114 364-368 NN denotes bone
T3113 369-378 NN denotes phenotype
T3115 379-383 WDT denotes that
T3117 384-389 MD denotes might
T3116 390-395 VB denotes arise
T3118 396-405 JJ denotes secondary
T3119 406-408 IN denotes to
T3120 409-415 NN denotes gender
T3122 416-418 CC denotes or
T3123 419-425 NN denotes weight
T3121 426-437 NNS denotes differences
T3124 437-439 , denotes ,
T3125 439-441 PRP denotes we
T3109 442-450 VBD denotes selected
T3126 451-454 NN denotes age
T3128 454-455 HYPH denotes -
T3127 455-462 VBN denotes matched
T3130 463-469 JJ denotes female
T3129 470-474 NNS denotes mice
T3131 475-478 IN denotes for
T3132 479-484 DT denotes these
T3133 485-493 NNS denotes analyses
T3134 493-494 . denotes .
T3135 494-742 sentence denotes The female mice demonstrated similar increases in body weight, although 4-month-old Sam68−/− mice weighed less than Sam68+/+ mice, and similar changes in bone lengths in the axial and appendicular skeleton between 4 and 12 months of age (Table 2).
T3136 495-498 DT denotes The
T3138 499-505 JJ denotes female
T3137 506-510 NNS denotes mice
T3139 511-523 VBD denotes demonstrated
T3140 524-531 JJ denotes similar
T3141 532-541 NNS denotes increases
T3142 542-544 IN denotes in
T3143 545-549 NN denotes body
T3144 550-556 NN denotes weight
T3145 556-558 , denotes ,
T3147 558-566 IN denotes although
T3148 567-568 CD denotes 4
T3150 568-569 HYPH denotes -
T3149 569-574 NN denotes month
T3152 574-575 HYPH denotes -
T3151 575-578 JJ denotes old
T3154 579-584 NN denotes Sam68
T3155 584-585 SYM denotes −
T3156 585-586 HYPH denotes /
T3157 586-587 SYM denotes −
T3153 588-592 NNS denotes mice
T3146 593-600 VBD denotes weighed
T3158 601-605 JJR denotes less
T3159 606-610 IN denotes than
T3160 611-616 NN denotes Sam68
T3162 616-617 SYM denotes +
T3163 617-618 HYPH denotes /
T3164 618-619 SYM denotes +
T3161 620-624 NNS denotes mice
T3165 624-626 , denotes ,
T3166 626-629 CC denotes and
T3167 630-637 JJ denotes similar
T3168 638-645 NNS denotes changes
T3169 646-648 IN denotes in
T3170 649-653 NN denotes bone
T3171 654-661 NNS denotes lengths
T3172 662-664 IN denotes in
T3173 665-668 DT denotes the
T3175 669-674 JJ denotes axial
T3176 675-678 CC denotes and
T3177 679-691 JJ denotes appendicular
T3174 692-700 NN denotes skeleton
T3178 701-708 IN denotes between
T3179 709-710 CD denotes 4
T3181 711-714 CC denotes and
T3182 715-717 CD denotes 12
T3180 718-724 NNS denotes months
T3183 725-727 IN denotes of
T3184 728-731 NN denotes age
T3185 732-733 -LRB- denotes (
T3186 733-738 NN denotes Table
T3187 739-740 CD denotes 2
T3188 740-741 -RRB- denotes )
T3189 741-742 . denotes .
T3190 742-1113 sentence denotes Faxitron radiography (Faxitron X-ray Corporation, Wheeling, Illinois, United States) (Figure 3A) and micro–computed tomography (CT) (Figure 3B) revealed significant cortical thinning (arrow) and a reduction in metaphyseal bone (asterisk) in the distal femora of 12-month-old Sam68+/+ mice compared with 4-month-old mice of either genotype and 12-month-old Sam68−/− mice.
T3191 743-751 NNP denotes Faxitron
T3192 752-763 NN denotes radiography
T3194 764-765 -LRB- denotes (
T3196 765-773 NNP denotes Faxitron
T3197 774-775 NN denotes X
T3199 775-776 HYPH denotes -
T3198 776-779 NN denotes ray
T3195 780-791 NNP denotes Corporation
T3200 791-793 , denotes ,
T3201 793-801 NNP denotes Wheeling
T3202 801-803 , denotes ,
T3203 803-811 NNP denotes Illinois
T3204 811-813 , denotes ,
T3205 813-819 NNP denotes United
T3206 820-826 NNP denotes States
T3207 826-827 -RRB- denotes )
T3208 828-829 -LRB- denotes (
T3210 829-835 NN denotes Figure
T3209 836-838 NN denotes 3A
T3211 838-839 -RRB- denotes )
T3212 840-843 CC denotes and
T3213 844-858 VBN denotes micro–computed
T3214 859-869 NN denotes tomography
T3215 870-871 -LRB- denotes (
T3216 871-873 NN denotes CT
T3217 873-874 -RRB- denotes )
T3218 875-876 -LRB- denotes (
T3220 876-882 NN denotes Figure
T3219 883-885 NN denotes 3B
T3221 885-886 -RRB- denotes )
T3193 887-895 VBD denotes revealed
T3222 896-907 JJ denotes significant
T3224 908-916 JJ denotes cortical
T3223 917-925 NN denotes thinning
T3225 926-927 -LRB- denotes (
T3226 927-932 NN denotes arrow
T3227 932-933 -RRB- denotes )
T3228 934-937 CC denotes and
T3229 938-939 DT denotes a
T3230 940-949 NN denotes reduction
T3231 950-952 IN denotes in
T3232 953-964 JJ denotes metaphyseal
T3233 965-969 NN denotes bone
T3234 970-971 -LRB- denotes (
T3235 971-979 NN denotes asterisk
T3236 979-980 -RRB- denotes )
T3237 981-983 IN denotes in
T3238 984-987 DT denotes the
T3240 988-994 JJ denotes distal
T3239 995-1001 NNS denotes femora
T3241 1002-1004 IN denotes of
T3242 1005-1007 CD denotes 12
T3244 1007-1008 HYPH denotes -
T3243 1008-1013 NN denotes month
T3246 1013-1014 HYPH denotes -
T3245 1014-1017 JJ denotes old
T3248 1018-1023 NN denotes Sam68
T3249 1023-1024 SYM denotes +
T3250 1024-1025 HYPH denotes /
T3251 1025-1026 SYM denotes +
T3247 1027-1031 NNS denotes mice
T3252 1032-1040 VBN denotes compared
T3253 1041-1045 IN denotes with
T3254 1046-1047 CD denotes 4
T3256 1047-1048 HYPH denotes -
T3255 1048-1053 NN denotes month
T3258 1053-1054 HYPH denotes -
T3257 1054-1057 JJ denotes old
T3259 1058-1062 NNS denotes mice
T3260 1063-1065 IN denotes of
T3261 1066-1072 CC denotes either
T3262 1073-1081 NN denotes genotype
T3263 1082-1085 CC denotes and
T3264 1086-1088 CD denotes 12
T3266 1088-1089 HYPH denotes -
T3265 1089-1094 NN denotes month
T3268 1094-1095 HYPH denotes -
T3267 1095-1098 JJ denotes old
T3270 1099-1104 NN denotes Sam68
T3271 1104-1105 SYM denotes −
T3272 1105-1106 HYPH denotes /
T3273 1106-1107 SYM denotes −
T3269 1108-1112 NNS denotes mice
T3274 1112-1113 . denotes .
T3275 1113-1300 sentence denotes Similar reductions in trabecular bone were shown by Faxitron and micro-CT in the fifth lumbar vertebrae of the 12-month-old Sam68+/+ mice but not in the Sam68−/− mice (unpublished data).
T3276 1114-1121 JJ denotes Similar
T3277 1122-1132 NNS denotes reductions
T3279 1133-1135 IN denotes in
T3280 1136-1146 JJ denotes trabecular
T3281 1147-1151 NN denotes bone
T3282 1152-1156 VBD denotes were
T3278 1157-1162 VBN denotes shown
T3283 1163-1165 IN denotes by
T3284 1166-1174 NNP denotes Faxitron
T3285 1175-1178 CC denotes and
T3286 1179-1187 NN denotes micro-CT
T3287 1188-1190 IN denotes in
T3288 1191-1194 DT denotes the
T3290 1195-1200 JJ denotes fifth
T3291 1201-1207 NN denotes lumbar
T3289 1208-1217 NNS denotes vertebrae
T3292 1218-1220 IN denotes of
T3293 1221-1224 DT denotes the
T3295 1225-1227 CD denotes 12
T3297 1227-1228 HYPH denotes -
T3296 1228-1233 NN denotes month
T3299 1233-1234 HYPH denotes -
T3298 1234-1237 JJ denotes old
T3300 1238-1243 NN denotes Sam68
T3301 1243-1244 SYM denotes +
T3302 1244-1245 HYPH denotes /
T3303 1245-1246 SYM denotes +
T3294 1247-1251 NNS denotes mice
T3304 1252-1255 CC denotes but
T3305 1256-1259 RB denotes not
T3306 1260-1262 IN denotes in
T3307 1263-1266 DT denotes the
T3309 1267-1272 NN denotes Sam68
T3310 1272-1273 SYM denotes −
T3311 1273-1274 HYPH denotes /
T3312 1274-1275 SYM denotes −
T3308 1276-1280 NNS denotes mice
T3313 1281-1282 -LRB- denotes (
T3315 1282-1293 JJ denotes unpublished
T3314 1294-1298 NNS denotes data
T3316 1298-1299 -RRB- denotes )
T3317 1299-1300 . denotes .
T3318 1300-1583 sentence denotes Total body bone mineral content (BMC), quantified with a Lunar PIXImus mouse densitometer (GE-Lunar, Madison, Wisconsin, United States), increased in both Sam68+/+ and Sam68−/− mice between 4 months and 12 months of age, but only reached significance in the Sam68−/− mice (Table 2).
T3319 1301-1306 JJ denotes Total
T3321 1307-1311 NN denotes body
T3322 1312-1316 NN denotes bone
T3323 1317-1324 NN denotes mineral
T3320 1325-1332 NN denotes content
T3325 1333-1334 -LRB- denotes (
T3326 1334-1337 NN denotes BMC
T3327 1337-1338 -RRB- denotes )
T3328 1338-1340 , denotes ,
T3329 1340-1350 VBN denotes quantified
T3330 1351-1355 IN denotes with
T3331 1356-1357 DT denotes a
T3333 1358-1363 JJ denotes Lunar
T3334 1364-1371 NNP denotes PIXImus
T3335 1372-1377 NN denotes mouse
T3332 1378-1390 NN denotes densitometer
T3336 1391-1392 -LRB- denotes (
T3338 1392-1394 NNP denotes GE
T3339 1394-1395 HYPH denotes -
T3337 1395-1400 NNP denotes Lunar
T3340 1400-1402 , denotes ,
T3341 1402-1409 NNP denotes Madison
T3342 1409-1411 , denotes ,
T3343 1411-1420 NNP denotes Wisconsin
T3344 1420-1422 , denotes ,
T3345 1422-1428 NNP denotes United
T3346 1429-1435 NNP denotes States
T3347 1435-1436 -RRB- denotes )
T3348 1436-1438 , denotes ,
T3324 1438-1447 VBD denotes increased
T3349 1448-1450 IN denotes in
T3350 1451-1455 CC denotes both
T3351 1456-1461 NN denotes Sam68
T3353 1461-1462 SYM denotes +
T3354 1462-1463 HYPH denotes /
T3355 1463-1464 SYM denotes +
T3356 1465-1468 CC denotes and
T3357 1469-1474 NN denotes Sam68
T3358 1474-1475 SYM denotes −
T3359 1475-1476 HYPH denotes /
T3360 1476-1477 SYM denotes −
T3352 1478-1482 NNS denotes mice
T3361 1483-1490 IN denotes between
T3362 1491-1492 CD denotes 4
T3363 1493-1499 NNS denotes months
T3364 1500-1503 CC denotes and
T3365 1504-1506 CD denotes 12
T3366 1507-1513 NNS denotes months
T3367 1514-1516 IN denotes of
T3368 1517-1520 NN denotes age
T3369 1520-1522 , denotes ,
T3370 1522-1525 CC denotes but
T3371 1526-1530 RB denotes only
T3372 1531-1538 VBD denotes reached
T3373 1539-1551 NN denotes significance
T3374 1552-1554 IN denotes in
T3375 1555-1558 DT denotes the
T3377 1559-1564 NN denotes Sam68
T3378 1564-1565 SYM denotes −
T3379 1565-1566 HYPH denotes /
T3380 1566-1567 SYM denotes −
T3376 1568-1572 NNS denotes mice
T3381 1573-1574 -LRB- denotes (
T3382 1574-1579 NN denotes Table
T3383 1580-1581 CD denotes 2
T3384 1581-1582 -RRB- denotes )
T3385 1582-1583 . denotes .
T3386 1583-1677 sentence denotes Similarly, a greater increase in BMC was seen in the femur and vertebra in the Sam68−/− mice.
T3387 1584-1593 RB denotes Similarly
T3389 1593-1595 , denotes ,
T3390 1595-1596 DT denotes a
T3392 1597-1604 JJR denotes greater
T3391 1605-1613 NN denotes increase
T3393 1614-1616 IN denotes in
T3394 1617-1620 NN denotes BMC
T3395 1621-1624 VBD denotes was
T3388 1625-1629 VBN denotes seen
T3396 1630-1632 IN denotes in
T3397 1633-1636 DT denotes the
T3398 1637-1642 NN denotes femur
T3399 1643-1646 CC denotes and
T3400 1647-1655 NN denotes vertebra
T3401 1656-1658 IN denotes in
T3402 1659-1662 DT denotes the
T3404 1663-1668 NN denotes Sam68
T3405 1668-1669 SYM denotes −
T3406 1669-1670 HYPH denotes /
T3407 1670-1671 SYM denotes −
T3403 1672-1676 NNS denotes mice
T3408 1676-1677 . denotes .
T3409 1677-1883 sentence denotes Bone mineral density (BMD) remained constant or decreased in the wild type mice but increased significantly in the total body and in the femoral and vertebral regions of interest in the Sam68−/− (Table 2).
T3410 1678-1682 NN denotes Bone
T3411 1683-1690 NN denotes mineral
T3412 1691-1698 NN denotes density
T3414 1699-1700 -LRB- denotes (
T3415 1700-1703 NN denotes BMD
T3416 1703-1704 -RRB- denotes )
T3413 1705-1713 VBD denotes remained
T3417 1714-1722 JJ denotes constant
T3418 1723-1725 CC denotes or
T3419 1726-1735 VBN denotes decreased
T3420 1736-1738 IN denotes in
T3421 1739-1742 DT denotes the
T3423 1743-1747 JJ denotes wild
T3424 1748-1752 NN denotes type
T3422 1753-1757 NNS denotes mice
T3425 1758-1761 CC denotes but
T3426 1762-1771 VBD denotes increased
T3427 1772-1785 RB denotes significantly
T3428 1786-1788 IN denotes in
T3429 1789-1792 DT denotes the
T3431 1793-1798 JJ denotes total
T3430 1799-1803 NN denotes body
T3432 1804-1807 CC denotes and
T3433 1808-1810 IN denotes in
T3434 1811-1814 DT denotes the
T3436 1815-1822 JJ denotes femoral
T3437 1823-1826 CC denotes and
T3438 1827-1836 JJ denotes vertebral
T3435 1837-1844 NNS denotes regions
T3439 1845-1847 IN denotes of
T3440 1848-1856 NN denotes interest
T3441 1857-1859 IN denotes in
T3442 1860-1863 DT denotes the
T3443 1864-1869 NN denotes Sam68
T3444 1869-1870 SYM denotes −
T3445 1870-1871 HYPH denotes /
T3446 1871-1872 SYM denotes −
T3447 1873-1874 -LRB- denotes (
T3448 1874-1879 NN denotes Table
T3449 1880-1881 CD denotes 2
T3450 1881-1882 -RRB- denotes )
T3451 1882-1883 . denotes .
T3452 1883-2022 sentence denotes These data showed that Sam68−/− mice continued to thrive and accrue bone in the axial and appendicular skeleton for longer than 12 months.
T3453 1884-1889 DT denotes These
T3454 1890-1894 NNS denotes data
T3455 1895-1901 VBD denotes showed
T3456 1902-1906 IN denotes that
T3458 1907-1912 NN denotes Sam68
T3460 1912-1913 SYM denotes −
T3461 1913-1914 HYPH denotes /
T3462 1914-1915 SYM denotes −
T3459 1916-1920 NNS denotes mice
T3457 1921-1930 VBD denotes continued
T3463 1931-1933 TO denotes to
T3464 1934-1940 VB denotes thrive
T3465 1941-1944 CC denotes and
T3466 1945-1951 VB denotes accrue
T3467 1952-1956 NN denotes bone
T3468 1957-1959 IN denotes in
T3469 1960-1963 DT denotes the
T3471 1964-1969 JJ denotes axial
T3472 1970-1973 CC denotes and
T3473 1974-1986 JJ denotes appendicular
T3470 1987-1995 NN denotes skeleton
T3474 1996-1999 IN denotes for
T3475 2000-2006 JJR denotes longer
T3477 2007-2011 IN denotes than
T3476 2012-2014 CD denotes 12
T3478 2015-2021 NNS denotes months
T3479 2021-2022 . denotes .
T3480 2022-2168 sentence denotes This was in contrast to the situation in age-matched, littermate controls in which a significant amount of bone was lost over the same timeframe.
T3481 2023-2027 DT denotes This
T3482 2028-2031 VBD denotes was
T3483 2032-2034 IN denotes in
T3484 2035-2043 NN denotes contrast
T3485 2044-2046 IN denotes to
T3486 2047-2050 DT denotes the
T3487 2051-2060 NN denotes situation
T3488 2061-2063 IN denotes in
T3489 2064-2067 NN denotes age
T3491 2067-2068 HYPH denotes -
T3490 2068-2075 VBN denotes matched
T3493 2075-2077 , denotes ,
T3494 2077-2087 NN denotes littermate
T3492 2088-2096 NNS denotes controls
T3495 2097-2099 IN denotes in
T3497 2100-2105 WDT denotes which
T3498 2106-2107 DT denotes a
T3500 2108-2119 JJ denotes significant
T3499 2120-2126 NN denotes amount
T3501 2127-2129 IN denotes of
T3502 2130-2134 NN denotes bone
T3503 2135-2138 VBD denotes was
T3496 2139-2143 VBN denotes lost
T3504 2144-2148 IN denotes over
T3505 2149-2152 DT denotes the
T3507 2153-2157 JJ denotes same
T3506 2158-2167 NN denotes timeframe
T3508 2167-2168 . denotes .
R1732 T3035 T3036 compound Sam68,Deficiency
R1733 T3036 T3037 nsubj Deficiency,Protects
R1734 T3038 T3037 dobj Mice,Protects
R1735 T3039 T3037 prep from,Protects
R1736 T3040 T3041 npadvmod Age,Related
R1737 T3041 T3043 amod Related,Loss
R1738 T3042 T3041 punct -,Related
R1739 T3043 T3039 pobj Loss,from
R1740 T3044 T3043 compound Bone,Loss
R1741 T3046 T3047 nmod Src,animals
R1742 T3047 T3049 nsubjpass animals,known
R1743 T3048 T3047 amod null,animals
R1744 T3050 T3049 auxpass are,known
R1745 T3051 T3052 aux to,have
R1746 T3052 T3049 xcomp have,known
R1747 T3053 T3054 compound bone,metabolism
R1748 T3054 T3055 compound metabolism,defects
R1749 T3055 T3052 dobj defects,have
R1750 T3056 T3057 punct [,48
R1751 T3057 T3049 parataxis 48,known
R1752 T3058 T3057 punct ],48
R1753 T3059 T3049 punct ", ",known
R1754 T3060 T3049 cc and,known
R1755 T3061 T3062 mark since,is
R1756 T3062 T3064 advcl is,decided
R1757 T3063 T3062 nsubj Sam68,is
R1758 T3064 T3049 conj decided,known
R1759 T3065 T3066 det a,substrate
R1760 T3066 T3062 attr substrate,is
R1761 T3067 T3066 prep of,substrate
R1762 T3068 T3067 pobj Src,of
R1763 T3069 T3064 punct ", ",decided
R1764 T3070 T3064 nsubj we,decided
R1765 T3071 T3072 aux to,analyze
R1766 T3072 T3064 xcomp analyze,decided
R1767 T3073 T3074 det the,mice
R1768 T3074 T3072 dobj mice,analyze
R1769 T3075 T3074 compound Sam68,mice
R1770 T3076 T3072 prep for,analyze
R1771 T3077 T3078 amod skeletal,abnormalities
R1772 T3078 T3076 pobj abnormalities,for
R1773 T3079 T3064 punct .,decided
R1774 T3081 T3082 nsubjpass Cohorts,euthanized
R1775 T3083 T3081 prep of,Cohorts
R1776 T3084 T3085 nmod Sam68,mice
R1777 T3085 T3083 pobj mice,of
R1778 T3086 T3084 punct +,Sam68
R1779 T3087 T3084 punct /,Sam68
R1780 T3088 T3084 punct +,Sam68
R1781 T3089 T3084 cc and,Sam68
R1782 T3090 T3084 conj Sam68,Sam68
R1783 T3091 T3090 punct −,Sam68
R1784 T3092 T3090 punct /,Sam68
R1785 T3093 T3090 punct −,Sam68
R1786 T3094 T3082 auxpass were,euthanized
R1787 T3095 T3082 prep at,euthanized
R1788 T3096 T3097 nummod 4,months
R1789 T3097 T3095 pobj months,at
R1790 T3098 T3096 cc and,4
R1791 T3099 T3096 conj 12,4
R1792 T3100 T3097 prep of,months
R1793 T3101 T3100 pobj age,of
R1794 T3102 T3082 prep for,euthanized
R1795 T3103 T3104 amod skeletal,phenotyping
R1796 T3104 T3102 pobj phenotyping,for
R1797 T3105 T3082 punct .,euthanized
R1798 T3107 T3108 aux To,minimize
R1799 T3108 T3109 advcl minimize,selected
R1800 T3110 T3108 dobj differences,minimize
R1801 T3111 T3110 prep in,differences
R1802 T3112 T3113 det the,phenotype
R1803 T3113 T3111 pobj phenotype,in
R1804 T3114 T3113 compound bone,phenotype
R1805 T3115 T3116 dep that,arise
R1806 T3116 T3110 relcl arise,differences
R1807 T3117 T3116 aux might,arise
R1808 T3118 T3116 advcl secondary,arise
R1809 T3119 T3118 prep to,secondary
R1810 T3120 T3121 nmod gender,differences
R1811 T3121 T3119 pobj differences,to
R1812 T3122 T3120 cc or,gender
R1813 T3123 T3120 conj weight,gender
R1814 T3124 T3109 punct ", ",selected
R1815 T3125 T3109 nsubj we,selected
R1816 T3126 T3127 npadvmod age,matched
R1817 T3127 T3129 amod matched,mice
R1818 T3128 T3127 punct -,matched
R1819 T3129 T3109 dobj mice,selected
R1820 T3130 T3129 amod female,mice
R1821 T3131 T3109 prep for,selected
R1822 T3132 T3133 det these,analyses
R1823 T3133 T3131 pobj analyses,for
R1824 T3134 T3109 punct .,selected
R1825 T3136 T3137 det The,mice
R1826 T3137 T3139 nsubj mice,demonstrated
R1827 T3138 T3137 amod female,mice
R1828 T3140 T3141 amod similar,increases
R1829 T3141 T3139 dobj increases,demonstrated
R1830 T3142 T3141 prep in,increases
R1831 T3143 T3144 compound body,weight
R1832 T3144 T3142 pobj weight,in
R1833 T3145 T3146 punct ", ",weighed
R1834 T3146 T3141 parataxis weighed,increases
R1835 T3147 T3146 mark although,weighed
R1836 T3148 T3149 nummod 4,month
R1837 T3149 T3151 npadvmod month,old
R1838 T3150 T3149 punct -,month
R1839 T3151 T3153 amod old,mice
R1840 T3152 T3151 punct -,old
R1841 T3153 T3146 nsubj mice,weighed
R1842 T3154 T3153 nmod Sam68,mice
R1843 T3155 T3154 punct −,Sam68
R1844 T3156 T3154 punct /,Sam68
R1845 T3157 T3154 punct −,Sam68
R1846 T3158 T3159 amod less,than
R1847 T3159 T3146 prep than,weighed
R1848 T3160 T3161 nmod Sam68,mice
R1849 T3161 T3159 pobj mice,than
R1850 T3162 T3160 punct +,Sam68
R1851 T3163 T3160 punct /,Sam68
R1852 T3164 T3160 punct +,Sam68
R1853 T3165 T3141 punct ", ",increases
R1854 T3166 T3141 cc and,increases
R1855 T3167 T3168 amod similar,changes
R1856 T3168 T3141 conj changes,increases
R1857 T3169 T3168 prep in,changes
R1858 T3170 T3171 compound bone,lengths
R1859 T3171 T3169 pobj lengths,in
R1860 T3172 T3168 prep in,changes
R1861 T3173 T3174 det the,skeleton
R1862 T3174 T3172 pobj skeleton,in
R1863 T3175 T3174 amod axial,skeleton
R1864 T3176 T3175 cc and,axial
R1865 T3177 T3175 conj appendicular,axial
R1866 T3178 T3168 prep between,changes
R1867 T3179 T3180 nummod 4,months
R1868 T3180 T3178 pobj months,between
R1869 T3181 T3179 cc and,4
R1870 T3182 T3179 conj 12,4
R1871 T3183 T3180 prep of,months
R1872 T3184 T3183 pobj age,of
R1873 T3185 T3186 punct (,Table
R1874 T3186 T3139 parataxis Table,demonstrated
R1875 T3187 T3186 nummod 2,Table
R1876 T3188 T3186 punct ),Table
R1877 T3189 T3139 punct .,demonstrated
R1878 T3191 T3192 compound Faxitron,radiography
R1879 T3192 T3193 nsubj radiography,revealed
R1880 T3194 T3195 punct (,Corporation
R1881 T3195 T3192 parataxis Corporation,radiography
R1882 T3196 T3195 compound Faxitron,Corporation
R1883 T3197 T3198 compound X,ray
R1884 T3198 T3195 compound ray,Corporation
R1885 T3199 T3198 punct -,ray
R1886 T3200 T3195 punct ", ",Corporation
R1887 T3201 T3195 npadvmod Wheeling,Corporation
R1888 T3202 T3195 punct ", ",Corporation
R1889 T3203 T3195 npadvmod Illinois,Corporation
R1890 T3204 T3195 punct ", ",Corporation
R1891 T3205 T3206 compound United,States
R1892 T3206 T3195 npadvmod States,Corporation
R1893 T3207 T3195 punct ),Corporation
R1894 T3208 T3209 punct (,3A
R1895 T3209 T3192 parataxis 3A,radiography
R1896 T3210 T3209 compound Figure,3A
R1897 T3211 T3209 punct ),3A
R1898 T3212 T3192 cc and,radiography
R1899 T3213 T3214 amod micro–computed,tomography
R1900 T3214 T3192 conj tomography,radiography
R1901 T3215 T3216 punct (,CT
R1902 T3216 T3214 parataxis CT,tomography
R1903 T3217 T3216 punct ),CT
R1904 T3218 T3219 punct (,3B
R1905 T3219 T3214 parataxis 3B,tomography
R1906 T3220 T3219 compound Figure,3B
R1907 T3221 T3219 punct ),3B
R1908 T3222 T3223 amod significant,thinning
R1909 T3223 T3193 dobj thinning,revealed
R1910 T3224 T3223 amod cortical,thinning
R1911 T3225 T3226 punct (,arrow
R1912 T3226 T3223 parataxis arrow,thinning
R1913 T3227 T3226 punct ),arrow
R1914 T3228 T3223 cc and,thinning
R1915 T3229 T3230 det a,reduction
R1916 T3230 T3223 conj reduction,thinning
R1917 T3231 T3230 prep in,reduction
R1918 T3232 T3233 amod metaphyseal,bone
R1919 T3233 T3231 pobj bone,in
R1920 T3234 T3235 punct (,asterisk
R1921 T3235 T3230 parataxis asterisk,reduction
R1922 T3236 T3235 punct ),asterisk
R1923 T3237 T3223 prep in,thinning
R1924 T3238 T3239 det the,femora
R1925 T3239 T3237 pobj femora,in
R1926 T3240 T3239 amod distal,femora
R1927 T3241 T3239 prep of,femora
R1928 T3242 T3243 nummod 12,month
R1929 T3243 T3245 npadvmod month,old
R1930 T3244 T3243 punct -,month
R1931 T3245 T3247 amod old,mice
R1932 T3246 T3245 punct -,old
R1933 T3247 T3241 pobj mice,of
R1934 T3248 T3247 nmod Sam68,mice
R1935 T3249 T3248 punct +,Sam68
R1936 T3250 T3248 punct /,Sam68
R1937 T3251 T3248 punct +,Sam68
R1938 T3252 T3223 prep compared,thinning
R1939 T3253 T3252 prep with,compared
R1940 T3254 T3255 nummod 4,month
R1941 T3255 T3257 npadvmod month,old
R1942 T3256 T3255 punct -,month
R1943 T3257 T3259 amod old,mice
R1944 T3258 T3257 punct -,old
R1945 T3259 T3253 pobj mice,with
R1946 T3260 T3259 prep of,mice
R1947 T3261 T3262 preconj either,genotype
R1948 T3262 T3260 pobj genotype,of
R1949 T3263 T3259 cc and,mice
R1950 T3264 T3265 nummod 12,month
R1951 T3265 T3267 npadvmod month,old
R1952 T3266 T3265 punct -,month
R1953 T3267 T3269 amod old,mice
R1954 T3268 T3267 punct -,old
R1955 T3269 T3259 conj mice,mice
R1956 T3270 T3269 nmod Sam68,mice
R1957 T3271 T3270 punct −,Sam68
R1958 T3272 T3270 punct /,Sam68
R1959 T3273 T3270 punct −,Sam68
R1960 T3274 T3193 punct .,revealed
R1961 T3276 T3277 amod Similar,reductions
R1962 T3277 T3278 nsubjpass reductions,shown
R1963 T3279 T3277 prep in,reductions
R1964 T3280 T3281 amod trabecular,bone
R1965 T3281 T3279 pobj bone,in
R1966 T3282 T3278 auxpass were,shown
R1967 T3283 T3278 prep by,shown
R1968 T3284 T3283 pobj Faxitron,by
R1969 T3285 T3284 cc and,Faxitron
R1970 T3286 T3284 conj micro-CT,Faxitron
R1971 T3287 T3278 prep in,shown
R1972 T3288 T3289 det the,vertebrae
R1973 T3289 T3287 pobj vertebrae,in
R1974 T3290 T3289 amod fifth,vertebrae
R1975 T3291 T3289 compound lumbar,vertebrae
R1976 T3292 T3289 prep of,vertebrae
R1977 T3293 T3294 det the,mice
R1978 T3294 T3292 pobj mice,of
R1979 T3295 T3296 nummod 12,month
R1980 T3296 T3298 npadvmod month,old
R1981 T3297 T3296 punct -,month
R1982 T3298 T3294 amod old,mice
R1983 T3299 T3298 punct -,old
R1984 T3300 T3294 nmod Sam68,mice
R1985 T3301 T3300 punct +,Sam68
R1986 T3302 T3300 punct /,Sam68
R1987 T3303 T3300 punct +,Sam68
R1988 T3304 T3287 cc but,in
R1989 T3305 T3304 neg not,but
R1990 T3306 T3287 conj in,in
R1991 T3307 T3308 det the,mice
R1992 T3308 T3306 pobj mice,in
R1993 T3309 T3308 nmod Sam68,mice
R1994 T3310 T3309 punct −,Sam68
R1995 T3311 T3309 punct /,Sam68
R1996 T3312 T3309 punct −,Sam68
R1997 T3313 T3314 punct (,data
R1998 T3314 T3278 meta data,shown
R1999 T3315 T3314 amod unpublished,data
R2000 T3316 T3314 punct ),data
R2001 T3317 T3278 punct .,shown
R2002 T3319 T3320 amod Total,content
R2003 T3320 T3324 nsubj content,increased
R2004 T3321 T3320 compound body,content
R2005 T3322 T3320 compound bone,content
R2006 T3323 T3320 compound mineral,content
R2007 T3325 T3320 punct (,content
R2008 T3326 T3320 appos BMC,content
R2009 T3327 T3320 punct ),content
R2010 T3328 T3320 punct ", ",content
R2011 T3329 T3320 acl quantified,content
R2012 T3330 T3329 prep with,quantified
R2013 T3331 T3332 det a,densitometer
R2014 T3332 T3330 pobj densitometer,with
R2015 T3333 T3334 amod Lunar,PIXImus
R2016 T3334 T3332 compound PIXImus,densitometer
R2017 T3335 T3332 compound mouse,densitometer
R2018 T3336 T3337 punct (,Lunar
R2019 T3337 T3332 parataxis Lunar,densitometer
R2020 T3338 T3337 compound GE,Lunar
R2021 T3339 T3337 punct -,Lunar
R2022 T3340 T3337 punct ", ",Lunar
R2023 T3341 T3337 npadvmod Madison,Lunar
R2024 T3342 T3337 punct ", ",Lunar
R2025 T3343 T3337 npadvmod Wisconsin,Lunar
R2026 T3344 T3337 punct ", ",Lunar
R2027 T3345 T3346 compound United,States
R2028 T3346 T3337 npadvmod States,Lunar
R2029 T3347 T3337 punct ),Lunar
R2030 T3348 T3324 punct ", ",increased
R2031 T3349 T3324 prep in,increased
R2032 T3350 T3351 preconj both,Sam68
R2033 T3351 T3352 nmod Sam68,mice
R2034 T3352 T3349 pobj mice,in
R2035 T3353 T3351 punct +,Sam68
R2036 T3354 T3351 punct /,Sam68
R2037 T3355 T3351 punct +,Sam68
R2038 T3356 T3351 cc and,Sam68
R2039 T3357 T3351 conj Sam68,Sam68
R2040 T3358 T3357 punct −,Sam68
R2041 T3359 T3357 punct /,Sam68
R2042 T3360 T3357 punct −,Sam68
R2043 T3361 T3352 prep between,mice
R2044 T3362 T3363 nummod 4,months
R2045 T3363 T3361 pobj months,between
R2046 T3364 T3363 cc and,months
R2047 T3365 T3366 nummod 12,months
R2048 T3366 T3363 conj months,months
R2049 T3367 T3363 prep of,months
R2050 T3368 T3367 pobj age,of
R2051 T3369 T3324 punct ", ",increased
R2052 T3370 T3324 cc but,increased
R2053 T3371 T3372 advmod only,reached
R2054 T3372 T3324 conj reached,increased
R2055 T3373 T3372 dobj significance,reached
R2056 T3374 T3372 prep in,reached
R2057 T3375 T3376 det the,mice
R2058 T3376 T3374 pobj mice,in
R2059 T3377 T3376 nmod Sam68,mice
R2060 T3378 T3377 punct −,Sam68
R2061 T3379 T3377 punct /,Sam68
R2062 T3380 T3377 punct −,Sam68
R2063 T3381 T3382 punct (,Table
R2064 T3382 T3372 parataxis Table,reached
R2065 T3383 T3382 nummod 2,Table
R2066 T3384 T3382 punct ),Table
R2067 T3385 T3324 punct .,increased
R2068 T3387 T3388 advmod Similarly,seen
R2069 T3389 T3388 punct ", ",seen
R2070 T3390 T3391 det a,increase
R2071 T3391 T3388 nsubjpass increase,seen
R2072 T3392 T3391 amod greater,increase
R2073 T3393 T3391 prep in,increase
R2074 T3394 T3393 pobj BMC,in
R2075 T3395 T3388 auxpass was,seen
R2076 T3396 T3388 prep in,seen
R2077 T3397 T3398 det the,femur
R2078 T3398 T3396 pobj femur,in
R2079 T3399 T3398 cc and,femur
R2080 T3400 T3398 conj vertebra,femur
R2081 T3401 T3398 prep in,femur
R2082 T3402 T3403 det the,mice
R2083 T3403 T3401 pobj mice,in
R2084 T3404 T3403 nmod Sam68,mice
R2085 T3405 T3404 punct −,Sam68
R2086 T3406 T3404 punct /,Sam68
R2087 T3407 T3404 punct −,Sam68
R2088 T3408 T3388 punct .,seen
R2089 T3410 T3411 compound Bone,mineral
R2090 T3411 T3412 compound mineral,density
R2091 T3412 T3413 nsubj density,remained
R2092 T3414 T3412 punct (,density
R2093 T3415 T3412 appos BMD,density
R2094 T3416 T3413 punct ),remained
R2095 T3417 T3413 acomp constant,remained
R2096 T3418 T3413 cc or,remained
R2097 T3419 T3413 conj decreased,remained
R2098 T3420 T3413 prep in,remained
R2099 T3421 T3422 det the,mice
R2100 T3422 T3420 pobj mice,in
R2101 T3423 T3424 amod wild,type
R2102 T3424 T3422 compound type,mice
R2103 T3425 T3413 cc but,remained
R2104 T3426 T3413 conj increased,remained
R2105 T3427 T3426 advmod significantly,increased
R2106 T3428 T3426 prep in,increased
R2107 T3429 T3430 det the,body
R2108 T3430 T3428 pobj body,in
R2109 T3431 T3430 amod total,body
R2110 T3432 T3428 cc and,in
R2111 T3433 T3428 conj in,in
R2112 T3434 T3435 det the,regions
R2113 T3435 T3433 pobj regions,in
R2114 T3436 T3435 amod femoral,regions
R2115 T3437 T3436 cc and,femoral
R2116 T3438 T3436 conj vertebral,femoral
R2117 T3439 T3435 prep of,regions
R2118 T3440 T3439 pobj interest,of
R2119 T3441 T3426 prep in,increased
R2120 T3442 T3443 det the,Sam68
R2121 T3443 T3441 pobj Sam68,in
R2122 T3444 T3443 punct −,Sam68
R2123 T3445 T3443 punct /,Sam68
R2124 T3446 T3443 punct −,Sam68
R2125 T3447 T3448 punct (,Table
R2126 T3448 T3426 parataxis Table,increased
R2127 T3449 T3448 nummod 2,Table
R2128 T3450 T3448 punct ),Table
R2129 T3451 T3413 punct .,remained
R2130 T3453 T3454 det These,data
R2131 T3454 T3455 nsubj data,showed
R2132 T3456 T3457 mark that,continued
R2133 T3457 T3455 ccomp continued,showed
R2134 T3458 T3459 nmod Sam68,mice
R2135 T3459 T3457 nsubj mice,continued
R2136 T3460 T3458 punct −,Sam68
R2137 T3461 T3458 punct /,Sam68
R2138 T3462 T3458 punct −,Sam68
R2139 T3463 T3464 aux to,thrive
R2140 T3464 T3457 xcomp thrive,continued
R2141 T3465 T3464 cc and,thrive
R2142 T3466 T3464 conj accrue,thrive
R2143 T3467 T3466 dobj bone,accrue
R2144 T3468 T3466 prep in,accrue
R2145 T3469 T3470 det the,skeleton
R2146 T3470 T3468 pobj skeleton,in
R2147 T3471 T3470 amod axial,skeleton
R2148 T3472 T3471 cc and,axial
R2149 T3473 T3471 conj appendicular,axial
R2150 T3474 T3464 prep for,thrive
R2151 T3475 T3476 amod longer,12
R2152 T3476 T3478 nummod 12,months
R2153 T3477 T3476 quantmod than,12
R2154 T3478 T3474 pobj months,for
R2155 T3479 T3455 punct .,showed
R2156 T3481 T3482 nsubj This,was
R2157 T3483 T3482 prep in,was
R2158 T3484 T3483 pobj contrast,in
R2159 T3485 T3484 prep to,contrast
R2160 T3486 T3487 det the,situation
R2161 T3487 T3485 pobj situation,to
R2162 T3488 T3487 prep in,situation
R2163 T3489 T3490 npadvmod age,matched
R2164 T3490 T3492 amod matched,controls
R2165 T3491 T3490 punct -,matched
R2166 T3492 T3488 pobj controls,in
R2167 T3493 T3492 punct ", ",controls
R2168 T3494 T3492 compound littermate,controls
R2169 T3495 T3496 prep in,lost
R2170 T3496 T3487 relcl lost,situation
R2171 T3497 T3495 pobj which,in
R2172 T3498 T3499 det a,amount
R2173 T3499 T3496 nsubjpass amount,lost
R2174 T3500 T3499 amod significant,amount
R2175 T3501 T3499 prep of,amount
R2176 T3502 T3501 pobj bone,of
R2177 T3503 T3496 auxpass was,lost
R2178 T3504 T3496 prep over,lost
R2179 T3505 T3506 det the,timeframe
R2180 T3506 T3504 pobj timeframe,over
R2181 T3507 T3506 amod same,timeframe
R2182 T3508 T3482 punct .,was