Id |
Subject |
Object |
Predicate |
Lexical cue |
T2528 |
0-2 |
TO |
denotes |
To |
T2529 |
3-9 |
VB |
denotes |
define |
T2531 |
10-13 |
DT |
denotes |
the |
T2533 |
14-25 |
JJ |
denotes |
physiologic |
T2532 |
26-30 |
NN |
denotes |
role |
T2534 |
31-33 |
IN |
denotes |
of |
T2535 |
34-39 |
NN |
denotes |
Sam68 |
T2536 |
39-41 |
, |
denotes |
, |
T2537 |
41-43 |
PRP |
denotes |
we |
T2530 |
44-53 |
VBD |
denotes |
generated |
T2538 |
54-59 |
NN |
denotes |
Sam68 |
T2540 |
59-60 |
HYPH |
denotes |
- |
T2539 |
60-69 |
JJ |
denotes |
deficient |
T2541 |
70-74 |
NNS |
denotes |
mice |
T2542 |
75-77 |
IN |
denotes |
by |
T2543 |
78-86 |
VBN |
denotes |
targeted |
T2544 |
87-97 |
NN |
denotes |
disruption |
T2545 |
98-100 |
IN |
denotes |
of |
T2546 |
101-106 |
NNS |
denotes |
exons |
T2547 |
107-108 |
CD |
denotes |
4 |
T2548 |
109-112 |
CC |
denotes |
and |
T2549 |
113-114 |
CD |
denotes |
5 |
T2550 |
115-117 |
IN |
denotes |
of |
T2551 |
118-121 |
DT |
denotes |
the |
T2553 |
122-127 |
NN |
denotes |
sam68 |
T2552 |
128-132 |
NN |
denotes |
gene |
T2554 |
132-134 |
, |
denotes |
, |
T2555 |
134-139 |
WDT |
denotes |
which |
T2556 |
140-146 |
VBP |
denotes |
encode |
T2557 |
147-150 |
DT |
denotes |
the |
T2559 |
151-161 |
JJ |
denotes |
functional |
T2558 |
162-168 |
NN |
denotes |
region |
T2560 |
169-171 |
IN |
denotes |
of |
T2561 |
172-175 |
DT |
denotes |
the |
T2563 |
176-178 |
NN |
denotes |
KH |
T2565 |
178-179 |
HYPH |
denotes |
- |
T2564 |
179-183 |
NN |
denotes |
type |
T2566 |
184-187 |
NN |
denotes |
RNA |
T2567 |
188-195 |
NN |
denotes |
binding |
T2562 |
196-202 |
NN |
denotes |
domain |
T2568 |
203-204 |
-LRB- |
denotes |
( |
T2570 |
204-210 |
NN |
denotes |
Figure |
T2569 |
211-213 |
NN |
denotes |
2A |
T2571 |
213-214 |
-RRB- |
denotes |
) |
T2572 |
214-215 |
. |
denotes |
. |
T2573 |
215-349 |
sentence |
denotes |
The integrity of the targeted allele was verified by Southern blot analysis (Figure 2B) and by PCR of genomic DNA (unpublished data). |
T2574 |
216-219 |
DT |
denotes |
The |
T2575 |
220-229 |
NN |
denotes |
integrity |
T2577 |
230-232 |
IN |
denotes |
of |
T2578 |
233-236 |
DT |
denotes |
the |
T2580 |
237-245 |
VBN |
denotes |
targeted |
T2579 |
246-252 |
NN |
denotes |
allele |
T2581 |
253-256 |
VBD |
denotes |
was |
T2576 |
257-265 |
VBN |
denotes |
verified |
T2582 |
266-268 |
IN |
denotes |
by |
T2583 |
269-277 |
NNP |
denotes |
Southern |
T2584 |
278-282 |
NN |
denotes |
blot |
T2585 |
283-291 |
NN |
denotes |
analysis |
T2586 |
292-293 |
-LRB- |
denotes |
( |
T2588 |
293-299 |
NN |
denotes |
Figure |
T2587 |
300-302 |
NN |
denotes |
2B |
T2589 |
302-303 |
-RRB- |
denotes |
) |
T2590 |
304-307 |
CC |
denotes |
and |
T2591 |
308-310 |
IN |
denotes |
by |
T2592 |
311-314 |
NN |
denotes |
PCR |
T2593 |
315-317 |
IN |
denotes |
of |
T2594 |
318-325 |
JJ |
denotes |
genomic |
T2595 |
326-329 |
NN |
denotes |
DNA |
T2596 |
330-331 |
-LRB- |
denotes |
( |
T2598 |
331-342 |
JJ |
denotes |
unpublished |
T2597 |
343-347 |
NNS |
denotes |
data |
T2599 |
347-348 |
-RRB- |
denotes |
) |
T2600 |
348-349 |
. |
denotes |
. |
T2601 |
349-649 |
sentence |
denotes |
Sam68 transcripts encoded by exons 1 to 5 were absent as evidenced by RT-PCR (Dataset S2), and Sam68−/− mice were devoid of Sam68 protein, as visualized by immunoblotting with anti-Sam68 AD1 and SC-333 antibodies or control normal rabbit serum or anti-Sam68 AD1 preabsorbed with peptide (Figure 2C). |
T2602 |
350-355 |
NN |
denotes |
Sam68 |
T2603 |
356-367 |
NNS |
denotes |
transcripts |
T2605 |
368-375 |
VBN |
denotes |
encoded |
T2606 |
376-378 |
IN |
denotes |
by |
T2607 |
379-384 |
NNS |
denotes |
exons |
T2608 |
385-386 |
CD |
denotes |
1 |
T2609 |
387-389 |
IN |
denotes |
to |
T2610 |
390-391 |
CD |
denotes |
5 |
T2604 |
392-396 |
VBD |
denotes |
were |
T2611 |
397-403 |
JJ |
denotes |
absent |
T2612 |
404-406 |
IN |
denotes |
as |
T2613 |
407-416 |
VBN |
denotes |
evidenced |
T2614 |
417-419 |
IN |
denotes |
by |
T2615 |
420-422 |
NN |
denotes |
RT |
T2617 |
422-423 |
HYPH |
denotes |
- |
T2616 |
423-426 |
NN |
denotes |
PCR |
T2618 |
427-428 |
-LRB- |
denotes |
( |
T2620 |
428-435 |
NN |
denotes |
Dataset |
T2619 |
436-438 |
NN |
denotes |
S2 |
T2621 |
438-439 |
-RRB- |
denotes |
) |
T2622 |
439-441 |
, |
denotes |
, |
T2623 |
441-444 |
CC |
denotes |
and |
T2624 |
445-450 |
NN |
denotes |
Sam68 |
T2626 |
450-451 |
SYM |
denotes |
− |
T2627 |
451-452 |
HYPH |
denotes |
/ |
T2628 |
452-453 |
SYM |
denotes |
− |
T2625 |
454-458 |
NNS |
denotes |
mice |
T2629 |
459-463 |
VBD |
denotes |
were |
T2630 |
464-470 |
JJ |
denotes |
devoid |
T2631 |
471-473 |
IN |
denotes |
of |
T2632 |
474-479 |
NN |
denotes |
Sam68 |
T2633 |
480-487 |
NN |
denotes |
protein |
T2634 |
487-489 |
, |
denotes |
, |
T2635 |
489-491 |
IN |
denotes |
as |
T2636 |
492-502 |
VBN |
denotes |
visualized |
T2637 |
503-505 |
IN |
denotes |
by |
T2638 |
506-520 |
VBG |
denotes |
immunoblotting |
T2639 |
521-525 |
IN |
denotes |
with |
T2640 |
526-536 |
JJ |
denotes |
anti-Sam68 |
T2641 |
537-540 |
NN |
denotes |
AD1 |
T2643 |
541-544 |
CC |
denotes |
and |
T2644 |
545-547 |
NN |
denotes |
SC |
T2645 |
547-548 |
HYPH |
denotes |
- |
T2646 |
548-551 |
CD |
denotes |
333 |
T2642 |
552-562 |
NNS |
denotes |
antibodies |
T2647 |
563-565 |
CC |
denotes |
or |
T2648 |
566-573 |
NN |
denotes |
control |
T2650 |
574-580 |
JJ |
denotes |
normal |
T2651 |
581-587 |
NN |
denotes |
rabbit |
T2649 |
588-593 |
NN |
denotes |
serum |
T2652 |
594-596 |
CC |
denotes |
or |
T2653 |
597-607 |
JJ |
denotes |
anti-Sam68 |
T2654 |
608-611 |
NN |
denotes |
AD1 |
T2655 |
612-623 |
VBN |
denotes |
preabsorbed |
T2656 |
624-628 |
IN |
denotes |
with |
T2657 |
629-636 |
NN |
denotes |
peptide |
T2658 |
637-638 |
-LRB- |
denotes |
( |
T2660 |
638-644 |
NN |
denotes |
Figure |
T2659 |
645-647 |
NN |
denotes |
2C |
T2661 |
647-648 |
-RRB- |
denotes |
) |
T2662 |
648-649 |
. |
denotes |
. |
T2663 |
649-757 |
sentence |
denotes |
SC-333 is a rabbit anti-Sam68 antibody that was raised against the C-terminal 20 amino acids of Sam68 [47]. |
T2664 |
650-652 |
NN |
denotes |
SC |
T2666 |
652-653 |
HYPH |
denotes |
- |
T2667 |
653-656 |
CD |
denotes |
333 |
T2665 |
657-659 |
VBZ |
denotes |
is |
T2668 |
660-661 |
DT |
denotes |
a |
T2670 |
662-668 |
NN |
denotes |
rabbit |
T2671 |
669-679 |
JJ |
denotes |
anti-Sam68 |
T2669 |
680-688 |
NN |
denotes |
antibody |
T2672 |
689-693 |
WDT |
denotes |
that |
T2674 |
694-697 |
VBD |
denotes |
was |
T2673 |
698-704 |
VBN |
denotes |
raised |
T2675 |
705-712 |
IN |
denotes |
against |
T2676 |
713-716 |
DT |
denotes |
the |
T2678 |
717-718 |
NN |
denotes |
C |
T2680 |
718-719 |
HYPH |
denotes |
- |
T2679 |
719-727 |
JJ |
denotes |
terminal |
T2681 |
728-730 |
CD |
denotes |
20 |
T2682 |
731-736 |
NN |
denotes |
amino |
T2677 |
737-742 |
NNS |
denotes |
acids |
T2683 |
743-745 |
IN |
denotes |
of |
T2684 |
746-751 |
NN |
denotes |
Sam68 |
T2685 |
752-753 |
-LRB- |
denotes |
[ |
T2686 |
753-755 |
CD |
denotes |
47 |
T2687 |
755-756 |
-RRB- |
denotes |
] |
T2688 |
756-757 |
. |
denotes |
. |
T2689 |
757-824 |
sentence |
denotes |
These data confirmed the generation of a mouse deficient in Sam68. |
T2690 |
758-763 |
DT |
denotes |
These |
T2691 |
764-768 |
NNS |
denotes |
data |
T2692 |
769-778 |
VBD |
denotes |
confirmed |
T2693 |
779-782 |
DT |
denotes |
the |
T2694 |
783-793 |
NN |
denotes |
generation |
T2695 |
794-796 |
IN |
denotes |
of |
T2696 |
797-798 |
DT |
denotes |
a |
T2697 |
799-804 |
NN |
denotes |
mouse |
T2698 |
805-814 |
JJ |
denotes |
deficient |
T2699 |
815-817 |
IN |
denotes |
in |
T2700 |
818-823 |
NN |
denotes |
Sam68 |
T2701 |
823-824 |
. |
denotes |
. |
T2702 |
824-936 |
sentence |
denotes |
The genotypes of offspring from heterozygote intercrosses exhibited a Mendelian segregation at E18.5 (Table 1). |
T2703 |
825-828 |
DT |
denotes |
The |
T2704 |
829-838 |
NNS |
denotes |
genotypes |
T2706 |
839-841 |
IN |
denotes |
of |
T2707 |
842-851 |
NN |
denotes |
offspring |
T2708 |
852-856 |
IN |
denotes |
from |
T2709 |
857-869 |
NN |
denotes |
heterozygote |
T2710 |
870-882 |
NNS |
denotes |
intercrosses |
T2705 |
883-892 |
VBD |
denotes |
exhibited |
T2711 |
893-894 |
DT |
denotes |
a |
T2713 |
895-904 |
JJ |
denotes |
Mendelian |
T2712 |
905-916 |
NN |
denotes |
segregation |
T2714 |
917-919 |
IN |
denotes |
at |
T2715 |
920-925 |
NN |
denotes |
E18.5 |
T2716 |
926-927 |
-LRB- |
denotes |
( |
T2717 |
927-932 |
NN |
denotes |
Table |
T2718 |
933-934 |
CD |
denotes |
1 |
T2719 |
934-935 |
-RRB- |
denotes |
) |
T2720 |
935-936 |
. |
denotes |
. |
T2721 |
936-1034 |
sentence |
denotes |
Despite the lack of visible deformity, many of the Sam68−/− pups died at birth of unknown causes. |
T2722 |
937-944 |
IN |
denotes |
Despite |
T2724 |
945-948 |
DT |
denotes |
the |
T2725 |
949-953 |
NN |
denotes |
lack |
T2726 |
954-956 |
IN |
denotes |
of |
T2727 |
957-964 |
JJ |
denotes |
visible |
T2728 |
965-974 |
NN |
denotes |
deformity |
T2729 |
974-976 |
, |
denotes |
, |
T2730 |
976-980 |
JJ |
denotes |
many |
T2731 |
981-983 |
IN |
denotes |
of |
T2732 |
984-987 |
DT |
denotes |
the |
T2734 |
988-993 |
NN |
denotes |
Sam68 |
T2735 |
993-994 |
SYM |
denotes |
− |
T2736 |
994-995 |
HYPH |
denotes |
/ |
T2737 |
995-996 |
SYM |
denotes |
− |
T2733 |
997-1001 |
NNS |
denotes |
pups |
T2723 |
1002-1006 |
VBD |
denotes |
died |
T2738 |
1007-1009 |
IN |
denotes |
at |
T2739 |
1010-1015 |
NN |
denotes |
birth |
T2740 |
1016-1018 |
IN |
denotes |
of |
T2741 |
1019-1026 |
JJ |
denotes |
unknown |
T2742 |
1027-1033 |
NNS |
denotes |
causes |
T2743 |
1033-1034 |
. |
denotes |
. |
T2744 |
1034-1157 |
sentence |
denotes |
Sam68+/- mice were phenotypically normal and Sam68−/− pups that survived the perinatal period invariably lived to old age. |
T2745 |
1035-1040 |
NN |
denotes |
Sam68 |
T2747 |
1040-1041 |
SYM |
denotes |
+ |
T2748 |
1041-1042 |
HYPH |
denotes |
/ |
T2749 |
1042-1043 |
SYM |
denotes |
- |
T2746 |
1044-1048 |
NNS |
denotes |
mice |
T2750 |
1049-1053 |
VBD |
denotes |
were |
T2751 |
1054-1068 |
RB |
denotes |
phenotypically |
T2752 |
1069-1075 |
JJ |
denotes |
normal |
T2753 |
1076-1079 |
CC |
denotes |
and |
T2754 |
1080-1085 |
NN |
denotes |
Sam68 |
T2756 |
1085-1086 |
SYM |
denotes |
− |
T2757 |
1086-1087 |
HYPH |
denotes |
/ |
T2758 |
1087-1088 |
SYM |
denotes |
− |
T2755 |
1089-1093 |
NNS |
denotes |
pups |
T2760 |
1094-1098 |
WDT |
denotes |
that |
T2761 |
1099-1107 |
VBD |
denotes |
survived |
T2762 |
1108-1111 |
DT |
denotes |
the |
T2764 |
1112-1121 |
JJ |
denotes |
perinatal |
T2763 |
1122-1128 |
NN |
denotes |
period |
T2765 |
1129-1139 |
RB |
denotes |
invariably |
T2759 |
1140-1145 |
VBD |
denotes |
lived |
T2766 |
1146-1148 |
IN |
denotes |
to |
T2767 |
1149-1152 |
JJ |
denotes |
old |
T2768 |
1153-1156 |
NN |
denotes |
age |
T2769 |
1156-1157 |
. |
denotes |
. |
T2770 |
1157-1342 |
sentence |
denotes |
Despite evidence that Sam68 mRNA is widely expressed and phosphorylated in mitosis [41,42], the Sam68−/− mice did not develop tumors and showed no immunologic or other major illnesses. |
T2771 |
1158-1165 |
IN |
denotes |
Despite |
T2773 |
1166-1174 |
NN |
denotes |
evidence |
T2774 |
1175-1179 |
IN |
denotes |
that |
T2776 |
1180-1185 |
NN |
denotes |
Sam68 |
T2777 |
1186-1190 |
NN |
denotes |
mRNA |
T2778 |
1191-1193 |
VBZ |
denotes |
is |
T2779 |
1194-1200 |
RB |
denotes |
widely |
T2775 |
1201-1210 |
VBN |
denotes |
expressed |
T2780 |
1211-1214 |
CC |
denotes |
and |
T2781 |
1215-1229 |
VBN |
denotes |
phosphorylated |
T2782 |
1230-1232 |
IN |
denotes |
in |
T2783 |
1233-1240 |
NN |
denotes |
mitosis |
T2784 |
1241-1242 |
-LRB- |
denotes |
[ |
T2786 |
1242-1244 |
CD |
denotes |
41 |
T2787 |
1244-1245 |
, |
denotes |
, |
T2785 |
1245-1247 |
CD |
denotes |
42 |
T2788 |
1247-1248 |
-RRB- |
denotes |
] |
T2789 |
1248-1250 |
, |
denotes |
, |
T2790 |
1250-1253 |
DT |
denotes |
the |
T2792 |
1254-1259 |
NN |
denotes |
Sam68 |
T2793 |
1259-1260 |
SYM |
denotes |
− |
T2794 |
1260-1261 |
HYPH |
denotes |
/ |
T2795 |
1261-1262 |
SYM |
denotes |
− |
T2791 |
1263-1267 |
NNS |
denotes |
mice |
T2796 |
1268-1271 |
VBD |
denotes |
did |
T2797 |
1272-1275 |
RB |
denotes |
not |
T2772 |
1276-1283 |
VB |
denotes |
develop |
T2798 |
1284-1290 |
NNS |
denotes |
tumors |
T2799 |
1291-1294 |
CC |
denotes |
and |
T2800 |
1295-1301 |
VBD |
denotes |
showed |
T2801 |
1302-1304 |
DT |
denotes |
no |
T2803 |
1305-1316 |
JJ |
denotes |
immunologic |
T2804 |
1317-1319 |
CC |
denotes |
or |
T2805 |
1320-1325 |
JJ |
denotes |
other |
T2806 |
1326-1331 |
JJ |
denotes |
major |
T2802 |
1332-1341 |
NNS |
denotes |
illnesses |
T2807 |
1341-1342 |
. |
denotes |
. |
T2808 |
1342-1481 |
sentence |
denotes |
Sam68−/− mice did, however, have difficulty breeding due to male infertility and the females rarely provided adequate care to their young. |
T2809 |
1343-1348 |
NN |
denotes |
Sam68 |
T2811 |
1348-1349 |
SYM |
denotes |
− |
T2812 |
1349-1350 |
HYPH |
denotes |
/ |
T2813 |
1350-1351 |
SYM |
denotes |
− |
T2810 |
1352-1356 |
NNS |
denotes |
mice |
T2815 |
1357-1360 |
VBD |
denotes |
did |
T2816 |
1360-1362 |
, |
denotes |
, |
T2817 |
1362-1369 |
RB |
denotes |
however |
T2818 |
1369-1371 |
, |
denotes |
, |
T2814 |
1371-1375 |
VB |
denotes |
have |
T2819 |
1376-1386 |
NN |
denotes |
difficulty |
T2820 |
1387-1395 |
VBG |
denotes |
breeding |
T2821 |
1396-1399 |
IN |
denotes |
due |
T2822 |
1400-1402 |
IN |
denotes |
to |
T2823 |
1403-1407 |
JJ |
denotes |
male |
T2824 |
1408-1419 |
NN |
denotes |
infertility |
T2825 |
1420-1423 |
CC |
denotes |
and |
T2826 |
1424-1427 |
DT |
denotes |
the |
T2827 |
1428-1435 |
NNS |
denotes |
females |
T2829 |
1436-1442 |
RB |
denotes |
rarely |
T2828 |
1443-1451 |
VBD |
denotes |
provided |
T2830 |
1452-1460 |
JJ |
denotes |
adequate |
T2831 |
1461-1465 |
NN |
denotes |
care |
T2832 |
1466-1468 |
IN |
denotes |
to |
T2833 |
1469-1474 |
PRP$ |
denotes |
their |
T2834 |
1475-1480 |
JJ |
denotes |
young |
T2835 |
1480-1481 |
. |
denotes |
. |
R1439 |
T2528 |
T2529 |
aux |
To,define |
R1440 |
T2529 |
T2530 |
advcl |
define,generated |
R1441 |
T2531 |
T2532 |
det |
the,role |
R1442 |
T2532 |
T2529 |
dobj |
role,define |
R1443 |
T2533 |
T2532 |
amod |
physiologic,role |
R1444 |
T2534 |
T2532 |
prep |
of,role |
R1445 |
T2535 |
T2534 |
pobj |
Sam68,of |
R1446 |
T2536 |
T2530 |
punct |
", ",generated |
R1447 |
T2537 |
T2530 |
nsubj |
we,generated |
R1448 |
T2538 |
T2539 |
npadvmod |
Sam68,deficient |
R1449 |
T2539 |
T2541 |
amod |
deficient,mice |
R1450 |
T2540 |
T2539 |
punct |
-,deficient |
R1451 |
T2541 |
T2530 |
dobj |
mice,generated |
R1452 |
T2542 |
T2530 |
prep |
by,generated |
R1453 |
T2543 |
T2544 |
amod |
targeted,disruption |
R1454 |
T2544 |
T2542 |
pobj |
disruption,by |
R1455 |
T2545 |
T2544 |
prep |
of,disruption |
R1456 |
T2546 |
T2547 |
nmod |
exons,4 |
R1457 |
T2547 |
T2545 |
pobj |
4,of |
R1458 |
T2548 |
T2547 |
cc |
and,4 |
R1459 |
T2549 |
T2547 |
conj |
5,4 |
R1460 |
T2550 |
T2547 |
prep |
of,4 |
R1461 |
T2551 |
T2552 |
det |
the,gene |
R1462 |
T2552 |
T2550 |
pobj |
gene,of |
R1463 |
T2553 |
T2552 |
compound |
sam68,gene |
R1464 |
T2554 |
T2547 |
punct |
", ",4 |
R1465 |
T2555 |
T2556 |
dep |
which,encode |
R1466 |
T2556 |
T2547 |
relcl |
encode,4 |
R1467 |
T2557 |
T2558 |
det |
the,region |
R1468 |
T2558 |
T2556 |
dobj |
region,encode |
R1469 |
T2559 |
T2558 |
amod |
functional,region |
R1470 |
T2560 |
T2558 |
prep |
of,region |
R1471 |
T2561 |
T2562 |
det |
the,domain |
R1472 |
T2562 |
T2560 |
pobj |
domain,of |
R1473 |
T2563 |
T2564 |
compound |
KH,type |
R1474 |
T2564 |
T2562 |
compound |
type,domain |
R1475 |
T2565 |
T2564 |
punct |
-,type |
R1476 |
T2566 |
T2567 |
compound |
RNA,binding |
R1477 |
T2567 |
T2562 |
compound |
binding,domain |
R1478 |
T2568 |
T2569 |
punct |
(,2A |
R1479 |
T2569 |
T2530 |
parataxis |
2A,generated |
R1480 |
T2570 |
T2569 |
compound |
Figure,2A |
R1481 |
T2571 |
T2569 |
punct |
),2A |
R1482 |
T2572 |
T2530 |
punct |
.,generated |
R1483 |
T2574 |
T2575 |
det |
The,integrity |
R1484 |
T2575 |
T2576 |
nsubjpass |
integrity,verified |
R1485 |
T2577 |
T2575 |
prep |
of,integrity |
R1486 |
T2578 |
T2579 |
det |
the,allele |
R1487 |
T2579 |
T2577 |
pobj |
allele,of |
R1488 |
T2580 |
T2579 |
amod |
targeted,allele |
R1489 |
T2581 |
T2576 |
auxpass |
was,verified |
R1490 |
T2582 |
T2576 |
prep |
by,verified |
R1491 |
T2583 |
T2584 |
compound |
Southern,blot |
R1492 |
T2584 |
T2585 |
compound |
blot,analysis |
R1493 |
T2585 |
T2582 |
pobj |
analysis,by |
R1494 |
T2586 |
T2587 |
punct |
(,2B |
R1495 |
T2587 |
T2585 |
parataxis |
2B,analysis |
R1496 |
T2588 |
T2587 |
compound |
Figure,2B |
R1497 |
T2589 |
T2587 |
punct |
),2B |
R1498 |
T2590 |
T2582 |
cc |
and,by |
R1499 |
T2591 |
T2582 |
conj |
by,by |
R1500 |
T2592 |
T2591 |
pobj |
PCR,by |
R1501 |
T2593 |
T2592 |
prep |
of,PCR |
R1502 |
T2594 |
T2595 |
amod |
genomic,DNA |
R1503 |
T2595 |
T2593 |
pobj |
DNA,of |
R1504 |
T2596 |
T2597 |
punct |
(,data |
R1505 |
T2597 |
T2592 |
meta |
data,PCR |
R1506 |
T2598 |
T2597 |
amod |
unpublished,data |
R1507 |
T2599 |
T2597 |
punct |
),data |
R1508 |
T2600 |
T2576 |
punct |
.,verified |
R1509 |
T2602 |
T2603 |
compound |
Sam68,transcripts |
R1510 |
T2603 |
T2604 |
nsubj |
transcripts,were |
R1511 |
T2605 |
T2603 |
acl |
encoded,transcripts |
R1512 |
T2606 |
T2605 |
agent |
by,encoded |
R1513 |
T2607 |
T2608 |
nmod |
exons,1 |
R1514 |
T2608 |
T2606 |
pobj |
1,by |
R1515 |
T2609 |
T2608 |
prep |
to,1 |
R1516 |
T2610 |
T2609 |
pobj |
5,to |
R1517 |
T2611 |
T2604 |
acomp |
absent,were |
R1518 |
T2612 |
T2613 |
mark |
as,evidenced |
R1519 |
T2613 |
T2604 |
advcl |
evidenced,were |
R1520 |
T2614 |
T2613 |
prep |
by,evidenced |
R1521 |
T2615 |
T2616 |
compound |
RT,PCR |
R1522 |
T2616 |
T2614 |
pobj |
PCR,by |
R1523 |
T2617 |
T2616 |
punct |
-,PCR |
R1524 |
T2618 |
T2619 |
punct |
(,S2 |
R1525 |
T2619 |
T2613 |
parataxis |
S2,evidenced |
R1526 |
T2620 |
T2619 |
compound |
Dataset,S2 |
R1527 |
T2621 |
T2619 |
punct |
),S2 |
R1528 |
T2622 |
T2604 |
punct |
", ",were |
R1529 |
T2623 |
T2604 |
cc |
and,were |
R1530 |
T2624 |
T2625 |
nmod |
Sam68,mice |
R1531 |
T2625 |
T2629 |
nsubj |
mice,were |
R1532 |
T2626 |
T2624 |
punct |
−,Sam68 |
R1533 |
T2627 |
T2624 |
punct |
/,Sam68 |
R1534 |
T2628 |
T2624 |
punct |
−,Sam68 |
R1535 |
T2629 |
T2604 |
conj |
were,were |
R1536 |
T2630 |
T2629 |
acomp |
devoid,were |
R1537 |
T2631 |
T2630 |
prep |
of,devoid |
R1538 |
T2632 |
T2633 |
compound |
Sam68,protein |
R1539 |
T2633 |
T2631 |
pobj |
protein,of |
R1540 |
T2634 |
T2629 |
punct |
", ",were |
R1541 |
T2635 |
T2636 |
mark |
as,visualized |
R1542 |
T2636 |
T2629 |
advcl |
visualized,were |
R1543 |
T2637 |
T2636 |
prep |
by,visualized |
R1544 |
T2638 |
T2637 |
pcomp |
immunoblotting,by |
R1545 |
T2639 |
T2638 |
prep |
with,immunoblotting |
R1546 |
T2640 |
T2641 |
amod |
anti-Sam68,AD1 |
R1547 |
T2641 |
T2642 |
nmod |
AD1,antibodies |
R1548 |
T2642 |
T2639 |
pobj |
antibodies,with |
R1549 |
T2643 |
T2641 |
cc |
and,AD1 |
R1550 |
T2644 |
T2641 |
conj |
SC,AD1 |
R1551 |
T2645 |
T2644 |
punct |
-,SC |
R1552 |
T2646 |
T2644 |
nummod |
333,SC |
R1553 |
T2647 |
T2642 |
cc |
or,antibodies |
R1554 |
T2648 |
T2649 |
nmod |
control,serum |
R1555 |
T2649 |
T2642 |
conj |
serum,antibodies |
R1556 |
T2650 |
T2649 |
amod |
normal,serum |
R1557 |
T2651 |
T2649 |
compound |
rabbit,serum |
R1558 |
T2652 |
T2649 |
cc |
or,serum |
R1559 |
T2653 |
T2654 |
amod |
anti-Sam68,AD1 |
R1560 |
T2654 |
T2649 |
conj |
AD1,serum |
R1561 |
T2655 |
T2654 |
acl |
preabsorbed,AD1 |
R1562 |
T2656 |
T2655 |
prep |
with,preabsorbed |
R1563 |
T2657 |
T2656 |
pobj |
peptide,with |
R1564 |
T2658 |
T2659 |
punct |
(,2C |
R1565 |
T2659 |
T2629 |
parataxis |
2C,were |
R1566 |
T2660 |
T2659 |
compound |
Figure,2C |
R1567 |
T2661 |
T2659 |
punct |
),2C |
R1568 |
T2662 |
T2629 |
punct |
.,were |
R1569 |
T2664 |
T2665 |
nsubj |
SC,is |
R1570 |
T2666 |
T2664 |
punct |
-,SC |
R1571 |
T2667 |
T2664 |
nummod |
333,SC |
R1572 |
T2668 |
T2669 |
det |
a,antibody |
R1573 |
T2669 |
T2665 |
attr |
antibody,is |
R1574 |
T2670 |
T2669 |
nmod |
rabbit,antibody |
R1575 |
T2671 |
T2669 |
amod |
anti-Sam68,antibody |
R1576 |
T2672 |
T2673 |
dep |
that,raised |
R1577 |
T2673 |
T2669 |
relcl |
raised,antibody |
R1578 |
T2674 |
T2673 |
auxpass |
was,raised |
R1579 |
T2675 |
T2673 |
prep |
against,raised |
R1580 |
T2676 |
T2677 |
det |
the,acids |
R1581 |
T2677 |
T2675 |
pobj |
acids,against |
R1582 |
T2678 |
T2679 |
npadvmod |
C,terminal |
R1583 |
T2679 |
T2677 |
amod |
terminal,acids |
R1584 |
T2680 |
T2679 |
punct |
-,terminal |
R1585 |
T2681 |
T2677 |
nummod |
20,acids |
R1586 |
T2682 |
T2677 |
compound |
amino,acids |
R1587 |
T2683 |
T2677 |
prep |
of,acids |
R1588 |
T2684 |
T2683 |
pobj |
Sam68,of |
R1589 |
T2685 |
T2686 |
punct |
[,47 |
R1590 |
T2686 |
T2665 |
parataxis |
47,is |
R1591 |
T2687 |
T2686 |
punct |
],47 |
R1592 |
T2688 |
T2665 |
punct |
.,is |
R1593 |
T2690 |
T2691 |
det |
These,data |
R1594 |
T2691 |
T2692 |
nsubj |
data,confirmed |
R1595 |
T2693 |
T2694 |
det |
the,generation |
R1596 |
T2694 |
T2692 |
dobj |
generation,confirmed |
R1597 |
T2695 |
T2694 |
prep |
of,generation |
R1598 |
T2696 |
T2697 |
det |
a,mouse |
R1599 |
T2697 |
T2695 |
pobj |
mouse,of |
R1600 |
T2698 |
T2697 |
amod |
deficient,mouse |
R1601 |
T2699 |
T2698 |
prep |
in,deficient |
R1602 |
T2700 |
T2699 |
pobj |
Sam68,in |
R1603 |
T2701 |
T2692 |
punct |
.,confirmed |
R1604 |
T2703 |
T2704 |
det |
The,genotypes |
R1605 |
T2704 |
T2705 |
nsubj |
genotypes,exhibited |
R1606 |
T2706 |
T2704 |
prep |
of,genotypes |
R1607 |
T2707 |
T2706 |
pobj |
offspring,of |
R1608 |
T2708 |
T2707 |
prep |
from,offspring |
R1609 |
T2709 |
T2710 |
compound |
heterozygote,intercrosses |
R1610 |
T2710 |
T2708 |
pobj |
intercrosses,from |
R1611 |
T2711 |
T2712 |
det |
a,segregation |
R1612 |
T2712 |
T2705 |
dobj |
segregation,exhibited |
R1613 |
T2713 |
T2712 |
amod |
Mendelian,segregation |
R1614 |
T2714 |
T2705 |
prep |
at,exhibited |
R1615 |
T2715 |
T2714 |
pobj |
E18.5,at |
R1616 |
T2716 |
T2717 |
punct |
(,Table |
R1617 |
T2717 |
T2705 |
parataxis |
Table,exhibited |
R1618 |
T2718 |
T2717 |
nummod |
1,Table |
R1619 |
T2719 |
T2717 |
punct |
),Table |
R1620 |
T2720 |
T2705 |
punct |
.,exhibited |
R1621 |
T2722 |
T2723 |
prep |
Despite,died |
R1622 |
T2724 |
T2725 |
det |
the,lack |
R1623 |
T2725 |
T2722 |
pobj |
lack,Despite |
R1624 |
T2726 |
T2725 |
prep |
of,lack |
R1625 |
T2727 |
T2728 |
amod |
visible,deformity |
R1626 |
T2728 |
T2726 |
pobj |
deformity,of |
R1627 |
T2729 |
T2723 |
punct |
", ",died |
R1628 |
T2730 |
T2723 |
nsubj |
many,died |
R1629 |
T2731 |
T2730 |
prep |
of,many |
R1630 |
T2732 |
T2733 |
det |
the,pups |
R1631 |
T2733 |
T2731 |
pobj |
pups,of |
R1632 |
T2734 |
T2733 |
nmod |
Sam68,pups |
R1633 |
T2735 |
T2734 |
punct |
−,Sam68 |
R1634 |
T2736 |
T2734 |
punct |
/,Sam68 |
R1635 |
T2737 |
T2734 |
punct |
−,Sam68 |
R1636 |
T2738 |
T2723 |
prep |
at,died |
R1637 |
T2739 |
T2738 |
pobj |
birth,at |
R1638 |
T2740 |
T2723 |
prep |
of,died |
R1639 |
T2741 |
T2742 |
amod |
unknown,causes |
R1640 |
T2742 |
T2740 |
pobj |
causes,of |
R1641 |
T2743 |
T2723 |
punct |
.,died |
R1642 |
T2745 |
T2746 |
nmod |
Sam68,mice |
R1643 |
T2746 |
T2750 |
nsubj |
mice,were |
R1644 |
T2747 |
T2745 |
punct |
+,Sam68 |
R1645 |
T2748 |
T2745 |
punct |
/,Sam68 |
R1646 |
T2749 |
T2745 |
punct |
-,Sam68 |
R1647 |
T2751 |
T2752 |
advmod |
phenotypically,normal |
R1648 |
T2752 |
T2750 |
acomp |
normal,were |
R1649 |
T2753 |
T2750 |
cc |
and,were |
R1650 |
T2754 |
T2755 |
nmod |
Sam68,pups |
R1651 |
T2755 |
T2759 |
nsubj |
pups,lived |
R1652 |
T2756 |
T2754 |
punct |
−,Sam68 |
R1653 |
T2757 |
T2754 |
punct |
/,Sam68 |
R1654 |
T2758 |
T2754 |
punct |
−,Sam68 |
R1655 |
T2759 |
T2750 |
conj |
lived,were |
R1656 |
T2760 |
T2761 |
dep |
that,survived |
R1657 |
T2761 |
T2755 |
relcl |
survived,pups |
R1658 |
T2762 |
T2763 |
det |
the,period |
R1659 |
T2763 |
T2761 |
dobj |
period,survived |
R1660 |
T2764 |
T2763 |
amod |
perinatal,period |
R1661 |
T2765 |
T2759 |
advmod |
invariably,lived |
R1662 |
T2766 |
T2759 |
prep |
to,lived |
R1663 |
T2767 |
T2768 |
amod |
old,age |
R1664 |
T2768 |
T2766 |
pobj |
age,to |
R1665 |
T2769 |
T2759 |
punct |
.,lived |
R1666 |
T2771 |
T2772 |
prep |
Despite,develop |
R1667 |
T2773 |
T2771 |
pobj |
evidence,Despite |
R1668 |
T2774 |
T2775 |
mark |
that,expressed |
R1669 |
T2775 |
T2773 |
acl |
expressed,evidence |
R1670 |
T2776 |
T2777 |
compound |
Sam68,mRNA |
R1671 |
T2777 |
T2775 |
nsubjpass |
mRNA,expressed |
R1672 |
T2778 |
T2775 |
auxpass |
is,expressed |
R1673 |
T2779 |
T2775 |
advmod |
widely,expressed |
R1674 |
T2780 |
T2775 |
cc |
and,expressed |
R1675 |
T2781 |
T2775 |
conj |
phosphorylated,expressed |
R1676 |
T2782 |
T2781 |
prep |
in,phosphorylated |
R1677 |
T2783 |
T2782 |
pobj |
mitosis,in |
R1678 |
T2784 |
T2785 |
punct |
[,42 |
R1679 |
T2785 |
T2775 |
parataxis |
42,expressed |
R1680 |
T2786 |
T2785 |
nummod |
41,42 |
R1681 |
T2787 |
T2785 |
punct |
",",42 |
R1682 |
T2788 |
T2785 |
punct |
],42 |
R1683 |
T2789 |
T2772 |
punct |
", ",develop |
R1684 |
T2790 |
T2791 |
det |
the,mice |
R1685 |
T2791 |
T2772 |
nsubj |
mice,develop |
R1686 |
T2792 |
T2791 |
nmod |
Sam68,mice |
R1687 |
T2793 |
T2792 |
punct |
−,Sam68 |
R1688 |
T2794 |
T2792 |
punct |
/,Sam68 |
R1689 |
T2795 |
T2792 |
punct |
−,Sam68 |
R1690 |
T2796 |
T2772 |
aux |
did,develop |
R1691 |
T2797 |
T2772 |
neg |
not,develop |
R1692 |
T2798 |
T2772 |
dobj |
tumors,develop |
R1693 |
T2799 |
T2772 |
cc |
and,develop |
R1694 |
T2800 |
T2772 |
conj |
showed,develop |
R1695 |
T2801 |
T2802 |
det |
no,illnesses |
R1696 |
T2802 |
T2800 |
dobj |
illnesses,showed |
R1697 |
T2803 |
T2802 |
amod |
immunologic,illnesses |
R1698 |
T2804 |
T2803 |
cc |
or,immunologic |
R1699 |
T2805 |
T2806 |
amod |
other,major |
R1700 |
T2806 |
T2803 |
conj |
major,immunologic |
R1701 |
T2807 |
T2772 |
punct |
.,develop |
R1702 |
T2809 |
T2810 |
nmod |
Sam68,mice |
R1703 |
T2810 |
T2814 |
nsubj |
mice,have |
R1704 |
T2811 |
T2809 |
punct |
−,Sam68 |
R1705 |
T2812 |
T2809 |
punct |
/,Sam68 |
R1706 |
T2813 |
T2809 |
punct |
−,Sam68 |
R1707 |
T2815 |
T2814 |
aux |
did,have |
R1708 |
T2816 |
T2814 |
punct |
", ",have |
R1709 |
T2817 |
T2814 |
advmod |
however,have |
R1710 |
T2818 |
T2814 |
punct |
", ",have |
R1711 |
T2819 |
T2814 |
dobj |
difficulty,have |
R1712 |
T2820 |
T2819 |
acl |
breeding,difficulty |
R1713 |
T2821 |
T2814 |
prep |
due,have |
R1714 |
T2822 |
T2821 |
pcomp |
to,due |
R1715 |
T2823 |
T2824 |
amod |
male,infertility |
R1716 |
T2824 |
T2821 |
pobj |
infertility,due |
R1717 |
T2825 |
T2814 |
cc |
and,have |
R1718 |
T2826 |
T2827 |
det |
the,females |
R1719 |
T2827 |
T2828 |
nsubj |
females,provided |
R1720 |
T2828 |
T2814 |
conj |
provided,have |
R1721 |
T2829 |
T2828 |
advmod |
rarely,provided |
R1722 |
T2830 |
T2831 |
amod |
adequate,care |
R1723 |
T2831 |
T2828 |
dobj |
care,provided |
R1724 |
T2832 |
T2828 |
dative |
to,provided |
R1725 |
T2833 |
T2834 |
poss |
their,young |
R1726 |
T2834 |
T2832 |
pobj |
young,to |
R1727 |
T2835 |
T2828 |
punct |
.,provided |