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PMC:1310620 / 2444-4919 JSONTXT 5 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function

Id Subject Object Predicate Lexical cue
T923 11-13 NN denotes BC
T924 14-16 VBZ denotes is
T925 17-26 RB denotes currently
T926 27-30 DT denotes the
T928 31-38 VBG denotes leading
T927 39-44 NN denotes cause
T929 45-47 IN denotes of
T930 48-54 NN denotes cancer
T932 54-55 HYPH denotes -
T931 55-62 VBN denotes related
T933 63-68 NN denotes death
T934 69-71 IN denotes in
T935 72-75 DT denotes the
T937 76-82 NNP denotes United
T936 83-89 NNP denotes States
T938 89-91 , denotes ,
T939 91-98 VBG denotes causing
T940 99-101 CD denotes 28
T941 101-102 NN denotes %
T942 103-105 IN denotes of
T943 106-109 DT denotes all
T945 110-116 NN denotes cancer
T944 117-123 NNS denotes deaths
T946 124-125 -LRB- denotes [
T947 125-126 CD denotes 1
T948 126-127 -RRB- denotes ]
T949 127-128 . denotes .
T950 128-259 sentence denotes Although cigarette smoking is the primary risk factor, only 10–15% of heavy smokers (greater than 20 pack years) develop BC [1-3].
T951 129-137 IN denotes Although
T953 138-147 NN denotes cigarette
T954 148-155 NN denotes smoking
T952 156-158 VBZ denotes is
T956 159-162 DT denotes the
T958 163-170 JJ denotes primary
T959 171-175 NN denotes risk
T957 176-182 NN denotes factor
T960 182-184 , denotes ,
T961 184-188 RB denotes only
T963 189-191 CD denotes 10
T964 191-192 SYM denotes –
T962 192-194 CD denotes 15
T965 194-195 NN denotes %
T966 196-198 IN denotes of
T967 199-204 JJ denotes heavy
T968 205-212 NNS denotes smokers
T969 213-214 -LRB- denotes (
T971 214-221 JJR denotes greater
T973 222-226 IN denotes than
T972 227-229 CD denotes 20
T974 230-234 NN denotes pack
T970 235-240 NNS denotes years
T975 240-241 -RRB- denotes )
T955 242-249 VBP denotes develop
T976 250-252 NN denotes BC
T977 253-254 -LRB- denotes [
T978 254-255 CD denotes 1
T979 255-256 SYM denotes -
T980 256-257 CD denotes 3
T981 257-258 -RRB- denotes ]
T982 258-259 . denotes .
T983 259-446 sentence denotes Antioxidant and DNA repair enzymes that provide protection from the effects of cigarette smoke are expressed in the progenitor cells for BC, normal bronchial epithelial cells (NBEC) [1].
T984 260-271 NN denotes Antioxidant
T986 272-275 CC denotes and
T987 276-279 NN denotes DNA
T988 280-286 NN denotes repair
T985 287-294 NNS denotes enzymes
T990 295-299 WDT denotes that
T991 300-307 VBP denotes provide
T992 308-318 NN denotes protection
T993 319-323 IN denotes from
T994 324-327 DT denotes the
T995 328-335 NNS denotes effects
T996 336-338 IN denotes of
T997 339-348 NN denotes cigarette
T998 349-354 NN denotes smoke
T999 355-358 VBP denotes are
T989 359-368 VBN denotes expressed
T1000 369-371 IN denotes in
T1001 372-375 DT denotes the
T1003 376-386 NN denotes progenitor
T1002 387-392 NNS denotes cells
T1004 393-396 IN denotes for
T1005 397-399 NN denotes BC
T1006 399-401 , denotes ,
T1007 401-407 JJ denotes normal
T1009 408-417 JJ denotes bronchial
T1010 418-428 JJ denotes epithelial
T1008 429-434 NNS denotes cells
T1011 435-436 -LRB- denotes (
T1012 436-440 NN denotes NBEC
T1013 440-441 -RRB- denotes )
T1014 442-443 -LRB- denotes [
T1015 443-444 CD denotes 1
T1016 444-445 -RRB- denotes ]
T1017 445-446 . denotes .
T1018 446-561 sentence denotes Inherited inter-individual variation in the function of these genes plays a role in determining risk for BC [4-6].
T1019 447-456 VBN denotes Inherited
T1021 457-473 JJ denotes inter-individual
T1020 474-483 NN denotes variation
T1023 484-486 IN denotes in
T1024 487-490 DT denotes the
T1025 491-499 NN denotes function
T1026 500-502 IN denotes of
T1027 503-508 DT denotes these
T1028 509-514 NNS denotes genes
T1022 515-520 VBZ denotes plays
T1029 521-522 DT denotes a
T1030 523-527 NN denotes role
T1031 528-530 IN denotes in
T1032 531-542 VBG denotes determining
T1033 543-547 NN denotes risk
T1034 548-551 IN denotes for
T1035 552-554 NN denotes BC
T1036 555-556 -LRB- denotes [
T1037 556-557 CD denotes 4
T1038 557-558 SYM denotes -
T1039 558-559 CD denotes 6
T1040 559-560 -RRB- denotes ]
T1041 560-561 . denotes .
T1042 561-783 sentence denotes Antioxidant enzymes protect NBEC from reactive oxygen species produced by interaction with and metabolism of xenobiotics such as pollution and cigarette smoke [4-7] as well as those produced by normal cellular metabolism.
T1043 562-573 NN denotes Antioxidant
T1044 574-581 NNS denotes enzymes
T1045 582-589 VBP denotes protect
T1046 590-594 NN denotes NBEC
T1047 595-599 IN denotes from
T1048 600-608 JJ denotes reactive
T1050 609-615 NN denotes oxygen
T1049 616-623 NNS denotes species
T1051 624-632 VBN denotes produced
T1052 633-635 IN denotes by
T1053 636-647 NN denotes interaction
T1054 648-652 IN denotes with
T1055 653-656 CC denotes and
T1056 657-667 NN denotes metabolism
T1058 668-670 IN denotes of
T1057 671-682 NNS denotes xenobiotics
T1059 683-687 JJ denotes such
T1060 688-690 IN denotes as
T1061 691-700 NN denotes pollution
T1062 701-704 CC denotes and
T1063 705-714 NN denotes cigarette
T1064 715-720 NN denotes smoke
T1065 721-722 -LRB- denotes [
T1066 722-723 CD denotes 4
T1067 723-724 SYM denotes -
T1068 724-725 CD denotes 7
T1069 725-726 -RRB- denotes ]
T1070 727-729 RB denotes as
T1072 730-734 RB denotes well
T1071 735-737 IN denotes as
T1073 738-743 DT denotes those
T1074 744-752 VBN denotes produced
T1075 753-755 IN denotes by
T1076 756-762 JJ denotes normal
T1078 763-771 JJ denotes cellular
T1077 772-782 NN denotes metabolism
T1079 782-783 . denotes .
T1080 783-980 sentence denotes Reactive oxygen species cause many damaging reactions including denaturation of proteins, cross-linking of lipids and proteins and modification of nucleic acid bases, which can lead to cancer [7].
T1081 784-792 JJ denotes Reactive
T1083 793-799 NN denotes oxygen
T1082 800-807 NNS denotes species
T1084 808-813 VBP denotes cause
T1085 814-818 JJ denotes many
T1087 819-827 VBG denotes damaging
T1086 828-837 NNS denotes reactions
T1088 838-847 VBG denotes including
T1089 848-860 NN denotes denaturation
T1090 861-863 IN denotes of
T1091 864-872 NN denotes proteins
T1092 872-874 , denotes ,
T1093 874-887 NN denotes cross-linking
T1094 888-890 IN denotes of
T1095 891-897 NNS denotes lipids
T1096 898-901 CC denotes and
T1097 902-910 NN denotes proteins
T1098 911-914 CC denotes and
T1099 915-927 NN denotes modification
T1100 928-930 IN denotes of
T1101 931-938 JJ denotes nucleic
T1102 939-943 NN denotes acid
T1103 944-949 NNS denotes bases
T1104 949-951 , denotes ,
T1105 951-956 WDT denotes which
T1107 957-960 MD denotes can
T1106 961-965 VB denotes lead
T1108 966-968 IN denotes to
T1109 969-975 NN denotes cancer
T1110 976-977 -LRB- denotes [
T1111 977-978 CD denotes 7
T1112 978-979 -RRB- denotes ]
T1113 979-980 . denotes .
T1114 980-1158 sentence denotes DNA repair enzymes repair the frequent damage to DNA caused by oxidant stress as well as other stresses, including bulky adducts derived from carcinogens in cigarette smoke [8].
T1115 981-984 NN denotes DNA
T1116 985-991 NN denotes repair
T1117 992-999 NNS denotes enzymes
T1118 1000-1006 VBP denotes repair
T1119 1007-1010 DT denotes the
T1121 1011-1019 JJ denotes frequent
T1120 1020-1026 NN denotes damage
T1122 1027-1029 IN denotes to
T1123 1030-1033 NN denotes DNA
T1124 1034-1040 VBN denotes caused
T1125 1041-1043 IN denotes by
T1126 1044-1051 NN denotes oxidant
T1127 1052-1058 NN denotes stress
T1128 1059-1061 RB denotes as
T1130 1062-1066 RB denotes well
T1129 1067-1069 IN denotes as
T1131 1070-1075 JJ denotes other
T1132 1076-1084 NNS denotes stresses
T1133 1084-1086 , denotes ,
T1134 1086-1095 VBG denotes including
T1135 1096-1101 JJ denotes bulky
T1136 1102-1109 NNS denotes adducts
T1137 1110-1117 VBN denotes derived
T1138 1118-1122 IN denotes from
T1139 1123-1134 NNS denotes carcinogens
T1140 1135-1137 IN denotes in
T1141 1138-1147 NN denotes cigarette
T1142 1148-1153 NN denotes smoke
T1143 1154-1155 -LRB- denotes [
T1144 1155-1156 CD denotes 8
T1145 1156-1157 -RRB- denotes ]
T1146 1157-1158 . denotes .
T1147 1158-1418 sentence denotes We previously reported that an interactive transcript abundance index comprising antioxidant genes was lower in NBEC of BC individuals compared to non-BC individuals, suggesting that BC individuals are selected on the basis of poor antioxidant protection [9].
T1148 1159-1161 PRP denotes We
T1150 1162-1172 RB denotes previously
T1149 1173-1181 VBD denotes reported
T1151 1182-1186 IN denotes that
T1153 1187-1189 DT denotes an
T1155 1190-1201 JJ denotes interactive
T1156 1202-1212 NN denotes transcript
T1157 1213-1222 NN denotes abundance
T1154 1223-1228 NN denotes index
T1158 1229-1239 VBG denotes comprising
T1159 1240-1251 NN denotes antioxidant
T1160 1252-1257 NNS denotes genes
T1152 1258-1261 VBD denotes was
T1161 1262-1267 JJR denotes lower
T1162 1268-1270 IN denotes in
T1163 1271-1275 NN denotes NBEC
T1164 1276-1278 IN denotes of
T1165 1279-1281 NN denotes BC
T1166 1282-1293 NNS denotes individuals
T1167 1294-1302 VBN denotes compared
T1168 1303-1305 IN denotes to
T1169 1306-1312 JJ denotes non-BC
T1170 1313-1324 NNS denotes individuals
T1171 1324-1326 , denotes ,
T1172 1326-1336 VBG denotes suggesting
T1173 1337-1341 IN denotes that
T1175 1342-1344 NN denotes BC
T1176 1345-1356 NNS denotes individuals
T1177 1357-1360 VBP denotes are
T1174 1361-1369 VBN denotes selected
T1178 1370-1372 IN denotes on
T1179 1373-1376 DT denotes the
T1180 1377-1382 NN denotes basis
T1181 1383-1385 IN denotes of
T1182 1386-1390 JJ denotes poor
T1184 1391-1402 NN denotes antioxidant
T1183 1403-1413 NN denotes protection
T1185 1414-1415 -LRB- denotes [
T1186 1415-1416 CD denotes 9
T1187 1416-1417 -RRB- denotes ]
T1188 1417-1418 . denotes .
T1189 1418-1605 sentence denotes In that study, there was a tendency towards correlation in transcript abundance between several pairs of antioxidant or DNA repair genes in non-BC individuals, but not in BC individuals.
T1190 1419-1421 IN denotes In
T1192 1422-1426 DT denotes that
T1193 1427-1432 NN denotes study
T1194 1432-1434 , denotes ,
T1195 1434-1439 EX denotes there
T1191 1440-1443 VBD denotes was
T1196 1444-1445 DT denotes a
T1197 1446-1454 NN denotes tendency
T1198 1455-1462 IN denotes towards
T1199 1463-1474 NN denotes correlation
T1200 1475-1477 IN denotes in
T1201 1478-1488 NN denotes transcript
T1202 1489-1498 NN denotes abundance
T1203 1499-1506 IN denotes between
T1204 1507-1514 JJ denotes several
T1205 1515-1520 NNS denotes pairs
T1206 1521-1523 IN denotes of
T1207 1524-1535 NN denotes antioxidant
T1209 1536-1538 CC denotes or
T1210 1539-1542 NN denotes DNA
T1211 1543-1549 NN denotes repair
T1208 1550-1555 NNS denotes genes
T1212 1556-1558 IN denotes in
T1213 1559-1565 JJ denotes non-BC
T1214 1566-1577 NNS denotes individuals
T1215 1577-1579 , denotes ,
T1216 1579-1582 CC denotes but
T1217 1583-1586 RB denotes not
T1218 1587-1589 IN denotes in
T1219 1590-1592 NN denotes BC
T1220 1593-1604 NNS denotes individuals
T1221 1604-1605 . denotes .
T1222 1605-1687 sentence denotes Gene pairs included in that observation were GSTP1/GPX1, CAT/GPX3, and GPX3/SOD1.
T1223 1606-1610 NN denotes Gene
T1224 1611-1616 NNS denotes pairs
T1226 1617-1625 VBN denotes included
T1227 1626-1628 IN denotes in
T1228 1629-1633 DT denotes that
T1229 1634-1645 NN denotes observation
T1225 1646-1650 VBD denotes were
T1230 1651-1656 NN denotes GSTP1
T1232 1656-1657 HYPH denotes /
T1231 1657-1661 NN denotes GPX1
T1233 1661-1663 , denotes ,
T1234 1663-1666 NN denotes CAT
T1236 1666-1667 HYPH denotes /
T1235 1667-1671 NN denotes GPX3
T1237 1671-1673 , denotes ,
T1238 1673-1676 CC denotes and
T1239 1677-1681 NN denotes GPX3
T1241 1681-1682 HYPH denotes /
T1240 1682-1686 NN denotes SOD1
T1242 1686-1687 . denotes .
T1243 1687-1752 sentence denotes Correlation is one typical characteristic of co-regulated genes.
T1244 1688-1699 NN denotes Correlation
T1245 1700-1702 VBZ denotes is
T1246 1703-1706 CD denotes one
T1248 1707-1714 JJ denotes typical
T1247 1715-1729 NN denotes characteristic
T1249 1730-1732 IN denotes of
T1250 1733-1745 VBN denotes co-regulated
T1251 1746-1751 NNS denotes genes
T1252 1751-1752 . denotes .
T1253 1752-1856 sentence denotes Another is shared transcription factor recognition sites in the regulatory regions of those genes [10].
T1254 1753-1760 DT denotes Another
T1255 1761-1763 VBZ denotes is
T1256 1764-1770 VBN denotes shared
T1258 1771-1784 NN denotes transcription
T1259 1785-1791 NN denotes factor
T1260 1792-1803 NN denotes recognition
T1257 1804-1809 NNS denotes sites
T1261 1810-1812 IN denotes in
T1262 1813-1816 DT denotes the
T1264 1817-1827 JJ denotes regulatory
T1263 1828-1835 NNS denotes regions
T1265 1836-1838 IN denotes of
T1266 1839-1844 DT denotes those
T1267 1845-1850 NNS denotes genes
T1268 1851-1852 -LRB- denotes [
T1269 1852-1854 CD denotes 10
T1270 1854-1855 -RRB- denotes ]
T1271 1855-1856 . denotes .
T1272 1856-2162 sentence denotes Based on the above findings, it was hypothesized first, that there is inter-individual variation in regulation of key antioxidant and DNA repair genes by one or more transcription factors and second, that individuals with sub-optimal regulation are selected for development of BC if they smoke cigarettes.
T1273 1857-1862 VBN denotes Based
T1275 1863-1865 IN denotes on
T1276 1866-1869 DT denotes the
T1278 1870-1875 JJ denotes above
T1277 1876-1884 NNS denotes findings
T1279 1884-1886 , denotes ,
T1280 1886-1888 PRP denotes it
T1281 1889-1892 VBD denotes was
T1274 1893-1905 VBN denotes hypothesized
T1282 1906-1911 RB denotes first
T1284 1911-1913 , denotes ,
T1285 1913-1917 IN denotes that
T1286 1918-1923 EX denotes there
T1283 1924-1926 VBZ denotes is
T1287 1927-1943 JJ denotes inter-individual
T1288 1944-1953 NN denotes variation
T1289 1954-1956 IN denotes in
T1290 1957-1967 NN denotes regulation
T1291 1968-1970 IN denotes of
T1292 1971-1974 JJ denotes key
T1294 1975-1986 NN denotes antioxidant
T1295 1987-1990 CC denotes and
T1296 1991-1994 NN denotes DNA
T1297 1995-2001 NN denotes repair
T1293 2002-2007 NNS denotes genes
T1298 2008-2010 IN denotes by
T1299 2011-2014 CD denotes one
T1301 2015-2017 CC denotes or
T1302 2018-2022 JJR denotes more
T1303 2023-2036 NN denotes transcription
T1300 2037-2044 NNS denotes factors
T1304 2045-2048 CC denotes and
T1305 2049-2055 RB denotes second
T1307 2055-2057 , denotes ,
T1308 2057-2061 IN denotes that
T1309 2062-2073 NNS denotes individuals
T1310 2074-2078 IN denotes with
T1311 2079-2090 JJ denotes sub-optimal
T1312 2091-2101 NN denotes regulation
T1313 2102-2105 VBP denotes are
T1306 2106-2114 VBN denotes selected
T1314 2115-2118 IN denotes for
T1315 2119-2130 NN denotes development
T1316 2131-2133 IN denotes of
T1317 2134-2136 NN denotes BC
T1318 2137-2139 IN denotes if
T1320 2140-2144 PRP denotes they
T1319 2145-2150 VBP denotes smoke
T1321 2151-2161 NNS denotes cigarettes
T1322 2161-2162 . denotes .
T1323 2162-2475 sentence denotes To test these hypotheses, transcription factor recognition sites common to the regulatory regions of the above correlated gene pairs were identified through in silico DNA sequence analysis, and their transcript abundance measured simultaneously with an expanded group of ten antioxidant and six DNA repair genes.
T1324 2163-2165 TO denotes To
T1325 2166-2170 VB denotes test
T1327 2171-2176 DT denotes these
T1328 2177-2187 NNS denotes hypotheses
T1329 2187-2189 , denotes ,
T1330 2189-2202 NN denotes transcription
T1331 2203-2209 NN denotes factor
T1333 2210-2221 NN denotes recognition
T1332 2222-2227 NNS denotes sites
T1334 2228-2234 JJ denotes common
T1335 2235-2237 IN denotes to
T1336 2238-2241 DT denotes the
T1338 2242-2252 JJ denotes regulatory
T1337 2253-2260 NNS denotes regions
T1339 2261-2263 IN denotes of
T1340 2264-2267 DT denotes the
T1342 2268-2273 JJ denotes above
T1343 2274-2284 VBN denotes correlated
T1344 2285-2289 NN denotes gene
T1341 2290-2295 NNS denotes pairs
T1345 2296-2300 VBD denotes were
T1326 2301-2311 VBN denotes identified
T1346 2312-2319 IN denotes through
T1347 2320-2322 FW denotes in
T1348 2323-2329 FW denotes silico
T1350 2330-2333 NN denotes DNA
T1351 2334-2342 NN denotes sequence
T1349 2343-2351 NN denotes analysis
T1352 2351-2353 , denotes ,
T1353 2353-2356 CC denotes and
T1354 2357-2362 PRP$ denotes their
T1356 2363-2373 NN denotes transcript
T1355 2374-2383 NN denotes abundance
T1357 2384-2392 VBN denotes measured
T1358 2393-2407 RB denotes simultaneously
T1359 2408-2412 IN denotes with
T1360 2413-2415 DT denotes an
T1362 2416-2424 VBN denotes expanded
T1361 2425-2430 NN denotes group
T1363 2431-2433 IN denotes of
T1364 2434-2437 CD denotes ten
T1365 2438-2449 NN denotes antioxidant
T1367 2450-2453 CC denotes and
T1368 2454-2457 CD denotes six
T1370 2458-2461 NN denotes DNA
T1369 2462-2468 NN denotes repair
T1366 2469-2474 NNS denotes genes
T1371 2474-2475 . denotes .
R394 T923 T924 nsubj BC,is
R395 T925 T924 advmod currently,is
R396 T926 T927 det the,cause
R397 T927 T924 attr cause,is
R398 T928 T927 amod leading,cause
R399 T929 T927 prep of,cause
R400 T930 T931 npadvmod cancer,related
R401 T931 T933 amod related,death
R402 T932 T931 punct -,related
R403 T933 T929 pobj death,of
R404 T934 T924 prep in,is
R405 T935 T936 det the,States
R406 T936 T934 pobj States,in
R407 T937 T936 compound United,States
R408 T938 T924 punct ", ",is
R409 T939 T924 advcl causing,is
R410 T940 T941 nummod 28,%
R411 T941 T939 dobj %,causing
R412 T942 T941 prep of,%
R413 T943 T944 det all,deaths
R414 T944 T942 pobj deaths,of
R415 T945 T944 compound cancer,deaths
R416 T946 T947 punct [,1
R417 T947 T924 parataxis 1,is
R418 T948 T947 punct ],1
R419 T949 T924 punct .,is
R420 T951 T952 mark Although,is
R421 T952 T955 advcl is,develop
R422 T953 T954 compound cigarette,smoking
R423 T954 T952 nsubj smoking,is
R424 T956 T957 det the,factor
R425 T957 T952 attr factor,is
R426 T958 T957 amod primary,factor
R427 T959 T957 compound risk,factor
R428 T960 T955 punct ", ",develop
R429 T961 T962 advmod only,15
R430 T962 T965 nummod 15,%
R431 T963 T962 quantmod 10,15
R432 T964 T962 punct –,15
R433 T965 T955 nsubj %,develop
R434 T966 T965 prep of,%
R435 T967 T968 amod heavy,smokers
R436 T968 T966 pobj smokers,of
R437 T969 T970 punct (,years
R438 T970 T968 parataxis years,smokers
R439 T971 T972 amod greater,20
R440 T972 T974 nummod 20,pack
R441 T973 T972 quantmod than,20
R442 T974 T970 compound pack,years
R443 T975 T970 punct ),years
R444 T976 T955 dobj BC,develop
R445 T977 T978 punct [,1
R446 T978 T955 parataxis 1,develop
R447 T979 T980 punct -,3
R448 T980 T978 prep 3,1
R449 T981 T978 punct ],1
R450 T982 T955 punct .,develop
R451 T984 T985 nmod Antioxidant,enzymes
R452 T985 T989 nsubjpass enzymes,expressed
R453 T986 T984 cc and,Antioxidant
R454 T987 T988 compound DNA,repair
R455 T988 T984 conj repair,Antioxidant
R456 T990 T991 dep that,provide
R457 T991 T985 relcl provide,enzymes
R458 T992 T991 dobj protection,provide
R459 T993 T992 prep from,protection
R460 T994 T995 det the,effects
R461 T995 T993 pobj effects,from
R462 T996 T995 prep of,effects
R463 T997 T998 compound cigarette,smoke
R464 T998 T996 pobj smoke,of
R465 T999 T989 auxpass are,expressed
R466 T1000 T989 prep in,expressed
R467 T1001 T1002 det the,cells
R468 T1002 T1000 pobj cells,in
R469 T1003 T1002 compound progenitor,cells
R470 T1004 T1002 prep for,cells
R471 T1005 T1004 pobj BC,for
R472 T1006 T1002 punct ", ",cells
R473 T1007 T1008 amod normal,cells
R474 T1008 T1002 appos cells,cells
R475 T1009 T1008 amod bronchial,cells
R476 T1010 T1008 amod epithelial,cells
R477 T1011 T1008 punct (,cells
R478 T1012 T1008 appos NBEC,cells
R479 T1013 T989 punct ),expressed
R480 T1014 T1015 punct [,1
R481 T1015 T989 parataxis 1,expressed
R482 T1016 T1015 punct ],1
R483 T1017 T989 punct .,expressed
R484 T1019 T1020 amod Inherited,variation
R485 T1020 T1022 nsubj variation,plays
R486 T1021 T1020 amod inter-individual,variation
R487 T1023 T1020 prep in,variation
R488 T1024 T1025 det the,function
R489 T1025 T1023 pobj function,in
R490 T1026 T1025 prep of,function
R491 T1027 T1028 det these,genes
R492 T1028 T1026 pobj genes,of
R493 T1029 T1030 det a,role
R494 T1030 T1022 dobj role,plays
R495 T1031 T1022 prep in,plays
R496 T1032 T1031 pcomp determining,in
R497 T1033 T1032 dobj risk,determining
R498 T1034 T1033 prep for,risk
R499 T1035 T1034 pobj BC,for
R500 T1036 T1037 punct [,4
R501 T1037 T1022 parataxis 4,plays
R502 T1038 T1039 punct -,6
R503 T1039 T1037 prep 6,4
R504 T1040 T1037 punct ],4
R505 T1041 T1022 punct .,plays
R506 T1043 T1044 compound Antioxidant,enzymes
R507 T1044 T1045 nsubj enzymes,protect
R508 T1046 T1045 dobj NBEC,protect
R509 T1047 T1045 prep from,protect
R510 T1048 T1049 amod reactive,species
R511 T1049 T1047 pobj species,from
R512 T1050 T1049 compound oxygen,species
R513 T1051 T1049 acl produced,species
R514 T1052 T1051 agent by,produced
R515 T1053 T1052 pobj interaction,by
R516 T1054 T1053 prep with,interaction
R517 T1055 T1053 cc and,interaction
R518 T1056 T1057 nmod metabolism,xenobiotics
R519 T1057 T1053 conj xenobiotics,interaction
R520 T1058 T1056 prep of,metabolism
R521 T1059 T1060 amod such,as
R522 T1060 T1057 prep as,xenobiotics
R523 T1061 T1060 pobj pollution,as
R524 T1062 T1061 cc and,pollution
R525 T1063 T1064 compound cigarette,smoke
R526 T1064 T1061 conj smoke,pollution
R527 T1065 T1066 punct [,4
R528 T1066 T1051 parataxis 4,produced
R529 T1067 T1068 punct -,7
R530 T1068 T1066 prep 7,4
R531 T1069 T1066 punct ],4
R532 T1070 T1071 advmod as,as
R533 T1071 T1049 cc as,species
R534 T1072 T1071 advmod well,as
R535 T1073 T1049 conj those,species
R536 T1074 T1073 acl produced,those
R537 T1075 T1074 agent by,produced
R538 T1076 T1077 amod normal,metabolism
R539 T1077 T1075 pobj metabolism,by
R540 T1078 T1077 amod cellular,metabolism
R541 T1079 T1045 punct .,protect
R542 T1081 T1082 amod Reactive,species
R543 T1082 T1084 nsubj species,cause
R544 T1083 T1082 compound oxygen,species
R545 T1085 T1086 amod many,reactions
R546 T1086 T1084 dobj reactions,cause
R547 T1087 T1086 amod damaging,reactions
R548 T1088 T1086 prep including,reactions
R549 T1089 T1088 pobj denaturation,including
R550 T1090 T1089 prep of,denaturation
R551 T1091 T1090 pobj proteins,of
R552 T1092 T1089 punct ", ",denaturation
R553 T1093 T1089 conj cross-linking,denaturation
R554 T1094 T1093 prep of,cross-linking
R555 T1095 T1094 pobj lipids,of
R556 T1096 T1095 cc and,lipids
R557 T1097 T1095 conj proteins,lipids
R558 T1098 T1093 cc and,cross-linking
R559 T1099 T1093 conj modification,cross-linking
R560 T1100 T1099 prep of,modification
R561 T1101 T1102 amod nucleic,acid
R562 T1102 T1103 compound acid,bases
R563 T1103 T1100 pobj bases,of
R564 T1104 T1086 punct ", ",reactions
R565 T1105 T1106 dep which,lead
R566 T1106 T1086 relcl lead,reactions
R567 T1107 T1106 aux can,lead
R568 T1108 T1106 prep to,lead
R569 T1109 T1108 pobj cancer,to
R570 T1110 T1111 punct [,7
R571 T1111 T1084 parataxis 7,cause
R572 T1112 T1111 punct ],7
R573 T1113 T1084 punct .,cause
R574 T1115 T1116 compound DNA,repair
R575 T1116 T1117 compound repair,enzymes
R576 T1117 T1118 nsubj enzymes,repair
R577 T1119 T1120 det the,damage
R578 T1120 T1118 dobj damage,repair
R579 T1121 T1120 amod frequent,damage
R580 T1122 T1120 prep to,damage
R581 T1123 T1122 pobj DNA,to
R582 T1124 T1120 acl caused,damage
R583 T1125 T1124 agent by,caused
R584 T1126 T1127 compound oxidant,stress
R585 T1127 T1125 pobj stress,by
R586 T1128 T1129 advmod as,as
R587 T1129 T1127 cc as,stress
R588 T1130 T1129 advmod well,as
R589 T1131 T1132 amod other,stresses
R590 T1132 T1127 conj stresses,stress
R591 T1133 T1120 punct ", ",damage
R592 T1134 T1120 prep including,damage
R593 T1135 T1136 amod bulky,adducts
R594 T1136 T1134 pobj adducts,including
R595 T1137 T1136 acl derived,adducts
R596 T1138 T1137 prep from,derived
R597 T1139 T1138 pobj carcinogens,from
R598 T1140 T1139 prep in,carcinogens
R599 T1141 T1142 compound cigarette,smoke
R600 T1142 T1140 pobj smoke,in
R601 T1143 T1144 punct [,8
R602 T1144 T1118 parataxis 8,repair
R603 T1145 T1144 punct ],8
R604 T1146 T1118 punct .,repair
R605 T1148 T1149 nsubj We,reported
R606 T1150 T1149 advmod previously,reported
R607 T1151 T1152 mark that,was
R608 T1152 T1149 ccomp was,reported
R609 T1153 T1154 det an,index
R610 T1154 T1152 nsubj index,was
R611 T1155 T1154 amod interactive,index
R612 T1156 T1157 compound transcript,abundance
R613 T1157 T1154 compound abundance,index
R614 T1158 T1154 acl comprising,index
R615 T1159 T1160 compound antioxidant,genes
R616 T1160 T1158 dobj genes,comprising
R617 T1161 T1152 acomp lower,was
R618 T1162 T1152 prep in,was
R619 T1163 T1162 pobj NBEC,in
R620 T1164 T1163 prep of,NBEC
R621 T1165 T1166 compound BC,individuals
R622 T1166 T1164 pobj individuals,of
R623 T1167 T1152 prep compared,was
R624 T1168 T1167 prep to,compared
R625 T1169 T1170 amod non-BC,individuals
R626 T1170 T1168 pobj individuals,to
R627 T1171 T1149 punct ", ",reported
R628 T1172 T1149 advcl suggesting,reported
R629 T1173 T1174 mark that,selected
R630 T1174 T1172 ccomp selected,suggesting
R631 T1175 T1176 compound BC,individuals
R632 T1176 T1174 nsubjpass individuals,selected
R633 T1177 T1174 auxpass are,selected
R634 T1178 T1174 prep on,selected
R635 T1179 T1180 det the,basis
R636 T1180 T1178 pobj basis,on
R637 T1181 T1180 prep of,basis
R638 T1182 T1183 amod poor,protection
R639 T1183 T1181 pobj protection,of
R640 T1184 T1183 compound antioxidant,protection
R641 T1185 T1186 punct [,9
R642 T1186 T1149 parataxis 9,reported
R643 T1187 T1186 punct ],9
R644 T1188 T1149 punct .,reported
R645 T1190 T1191 prep In,was
R646 T1192 T1193 det that,study
R647 T1193 T1190 pobj study,In
R648 T1194 T1191 punct ", ",was
R649 T1195 T1191 expl there,was
R650 T1196 T1197 det a,tendency
R651 T1197 T1191 attr tendency,was
R652 T1198 T1197 prep towards,tendency
R653 T1199 T1198 pobj correlation,towards
R654 T1200 T1199 prep in,correlation
R655 T1201 T1202 compound transcript,abundance
R656 T1202 T1200 pobj abundance,in
R657 T1203 T1199 prep between,correlation
R658 T1204 T1205 amod several,pairs
R659 T1205 T1203 pobj pairs,between
R660 T1206 T1205 prep of,pairs
R661 T1207 T1208 nmod antioxidant,genes
R662 T1208 T1206 pobj genes,of
R663 T1209 T1207 cc or,antioxidant
R664 T1210 T1211 compound DNA,repair
R665 T1211 T1207 conj repair,antioxidant
R666 T1212 T1191 prep in,was
R667 T1213 T1214 amod non-BC,individuals
R668 T1214 T1212 pobj individuals,in
R669 T1215 T1212 punct ", ",in
R670 T1216 T1212 cc but,in
R671 T1217 T1216 neg not,but
R672 T1218 T1212 conj in,in
R673 T1219 T1220 compound BC,individuals
R674 T1220 T1218 pobj individuals,in
R675 T1221 T1191 punct .,was
R676 T1223 T1224 compound Gene,pairs
R677 T1224 T1225 nsubj pairs,were
R678 T1226 T1224 acl included,pairs
R679 T1227 T1226 prep in,included
R680 T1228 T1229 det that,observation
R681 T1229 T1227 pobj observation,in
R682 T1230 T1231 compound GSTP1,GPX1
R683 T1231 T1225 attr GPX1,were
R684 T1232 T1231 punct /,GPX1
R685 T1233 T1231 punct ", ",GPX1
R686 T1234 T1235 compound CAT,GPX3
R687 T1235 T1231 conj GPX3,GPX1
R688 T1236 T1235 punct /,GPX3
R689 T1237 T1235 punct ", ",GPX3
R690 T1238 T1235 cc and,GPX3
R691 T1239 T1240 compound GPX3,SOD1
R692 T1240 T1235 conj SOD1,GPX3
R693 T1241 T1240 punct /,SOD1
R694 T1242 T1225 punct .,were
R695 T1244 T1245 nsubj Correlation,is
R696 T1246 T1247 nummod one,characteristic
R697 T1247 T1245 attr characteristic,is
R698 T1248 T1247 amod typical,characteristic
R699 T1249 T1247 prep of,characteristic
R700 T1250 T1251 amod co-regulated,genes
R701 T1251 T1249 pobj genes,of
R702 T1252 T1245 punct .,is
R703 T1254 T1255 nsubj Another,is
R704 T1256 T1257 amod shared,sites
R705 T1257 T1255 attr sites,is
R706 T1258 T1259 compound transcription,factor
R707 T1259 T1260 compound factor,recognition
R708 T1260 T1257 compound recognition,sites
R709 T1261 T1255 prep in,is
R710 T1262 T1263 det the,regions
R711 T1263 T1261 pobj regions,in
R712 T1264 T1263 amod regulatory,regions
R713 T1265 T1263 prep of,regions
R714 T1266 T1267 det those,genes
R715 T1267 T1265 pobj genes,of
R716 T1268 T1269 punct [,10
R717 T1269 T1255 parataxis 10,is
R718 T1270 T1269 punct ],10
R719 T1271 T1255 punct .,is
R720 T1273 T1274 prep Based,hypothesized
R721 T1275 T1273 prep on,Based
R722 T1276 T1277 det the,findings
R723 T1277 T1275 pobj findings,on
R724 T1278 T1277 amod above,findings
R725 T1279 T1274 punct ", ",hypothesized
R726 T1280 T1274 nsubjpass it,hypothesized
R727 T1281 T1274 auxpass was,hypothesized
R728 T1282 T1283 advmod first,is
R729 T1283 T1274 advcl is,hypothesized
R730 T1284 T1283 punct ", ",is
R731 T1285 T1283 mark that,is
R732 T1286 T1283 expl there,is
R733 T1287 T1288 amod inter-individual,variation
R734 T1288 T1283 attr variation,is
R735 T1289 T1283 prep in,is
R736 T1290 T1289 pobj regulation,in
R737 T1291 T1290 prep of,regulation
R738 T1292 T1293 amod key,genes
R739 T1293 T1291 pobj genes,of
R740 T1294 T1293 nmod antioxidant,genes
R741 T1295 T1294 cc and,antioxidant
R742 T1296 T1297 compound DNA,repair
R743 T1297 T1294 conj repair,antioxidant
R744 T1298 T1290 prep by,regulation
R745 T1299 T1300 nummod one,factors
R746 T1300 T1298 pobj factors,by
R747 T1301 T1299 cc or,one
R748 T1302 T1299 conj more,one
R749 T1303 T1300 compound transcription,factors
R750 T1304 T1283 cc and,is
R751 T1305 T1306 advmod second,selected
R752 T1306 T1283 conj selected,is
R753 T1307 T1306 punct ", ",selected
R754 T1308 T1306 mark that,selected
R755 T1309 T1306 nsubjpass individuals,selected
R756 T1310 T1309 prep with,individuals
R757 T1311 T1312 amod sub-optimal,regulation
R758 T1312 T1310 pobj regulation,with
R759 T1313 T1306 auxpass are,selected
R760 T1314 T1306 prep for,selected
R761 T1315 T1314 pobj development,for
R762 T1316 T1315 prep of,development
R763 T1317 T1316 pobj BC,of
R764 T1318 T1319 mark if,smoke
R765 T1319 T1306 advcl smoke,selected
R766 T1320 T1319 nsubj they,smoke
R767 T1321 T1319 dobj cigarettes,smoke
R768 T1322 T1274 punct .,hypothesized
R769 T1324 T1325 aux To,test
R770 T1325 T1326 advcl test,identified
R771 T1327 T1328 det these,hypotheses
R772 T1328 T1325 dobj hypotheses,test
R773 T1329 T1326 punct ", ",identified
R774 T1330 T1331 compound transcription,factor
R775 T1331 T1332 compound factor,sites
R776 T1332 T1326 nsubjpass sites,identified
R777 T1333 T1332 compound recognition,sites
R778 T1334 T1332 amod common,sites
R779 T1335 T1334 prep to,common
R780 T1336 T1337 det the,regions
R781 T1337 T1335 pobj regions,to
R782 T1338 T1337 amod regulatory,regions
R783 T1339 T1337 prep of,regions
R784 T1340 T1341 det the,pairs
R785 T1341 T1339 pobj pairs,of
R786 T1342 T1343 amod above,correlated
R787 T1343 T1341 amod correlated,pairs
R788 T1344 T1341 compound gene,pairs
R789 T1345 T1326 auxpass were,identified
R790 T1346 T1326 prep through,identified
R791 T1347 T1348 advmod in,silico
R792 T1348 T1349 amod silico,analysis
R793 T1349 T1346 pobj analysis,through
R794 T1350 T1351 compound DNA,sequence
R795 T1351 T1349 compound sequence,analysis
R796 T1352 T1326 punct ", ",identified
R797 T1353 T1326 cc and,identified
R798 T1354 T1355 poss their,abundance
R799 T1355 T1357 nsubj abundance,measured
R800 T1356 T1355 compound transcript,abundance
R801 T1357 T1326 conj measured,identified
R802 T1358 T1357 advmod simultaneously,measured
R803 T1359 T1358 prep with,simultaneously
R804 T1360 T1361 det an,group
R805 T1361 T1359 pobj group,with
R806 T1362 T1361 amod expanded,group
R807 T1363 T1361 prep of,group
R808 T1364 T1365 nummod ten,antioxidant
R809 T1365 T1366 nmod antioxidant,genes
R810 T1366 T1363 pobj genes,of
R811 T1367 T1365 cc and,antioxidant
R812 T1368 T1369 nummod six,repair
R813 T1369 T1365 conj repair,antioxidant
R814 T1370 T1369 compound DNA,repair
R815 T1371 T1326 punct .,identified