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PMC:1283364 / 725-1667 JSONTXT 4 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T257 0-7 NNS denotes Methods
T258 8-11 CC denotes and
T259 12-20 NNS denotes Findings
T260 20-166 sentence denotes We have generated a transgenic mouse model that genetically mimics the arrest of Aβ production expected from treatment with secretase inhibitors.
T261 21-23 PRP denotes We
T263 24-28 VBP denotes have
T262 29-38 VBN denotes generated
T264 39-40 DT denotes a
T266 41-51 JJ denotes transgenic
T267 52-57 NN denotes mouse
T265 58-63 NN denotes model
T268 64-68 WDT denotes that
T270 69-80 RB denotes genetically
T269 81-87 VBZ denotes mimics
T271 88-91 DT denotes the
T272 92-98 NN denotes arrest
T273 99-101 IN denotes of
T274 102-104 NN denotes Aβ
T275 105-115 NN denotes production
T276 116-124 VBN denotes expected
T277 125-129 IN denotes from
T278 130-139 NN denotes treatment
T279 140-144 IN denotes with
T280 145-154 NN denotes secretase
T281 155-165 NNS denotes inhibitors
T282 165-166 . denotes .
T283 166-252 sentence denotes These mice overexpress mutant APP from a vector that can be regulated by doxycycline.
T284 167-172 DT denotes These
T285 173-177 NNS denotes mice
T286 178-189 VBP denotes overexpress
T287 190-196 NN denotes mutant
T288 197-200 NN denotes APP
T289 201-205 IN denotes from
T290 206-207 DT denotes a
T291 208-214 NN denotes vector
T292 215-219 WDT denotes that
T294 220-223 MD denotes can
T295 224-226 VB denotes be
T293 227-236 VBN denotes regulated
T296 237-239 IN denotes by
T297 240-251 NN denotes doxycycline
T298 251-252 . denotes .
T299 252-351 sentence denotes Under normal conditions, high-level expression of APP quickly induces fulminant amyloid pathology.
T300 253-258 IN denotes Under
T302 259-265 JJ denotes normal
T303 266-276 NNS denotes conditions
T304 276-278 , denotes ,
T305 278-282 JJ denotes high
T307 282-283 HYPH denotes -
T306 283-288 NN denotes level
T308 289-299 NN denotes expression
T309 300-302 IN denotes of
T310 303-306 NN denotes APP
T311 307-314 RB denotes quickly
T301 315-322 VBZ denotes induces
T312 323-332 JJ denotes fulminant
T314 333-340 NN denotes amyloid
T313 341-350 NN denotes pathology
T315 350-351 . denotes .
T316 351-511 sentence denotes We show that doxycycline administration inhibits transgenic APP expression by greater than 95% and reduces Aβ production to levels found in nontransgenic mice.
T317 352-354 PRP denotes We
T318 355-359 VBP denotes show
T319 360-364 IN denotes that
T321 365-376 NN denotes doxycycline
T322 377-391 NN denotes administration
T320 392-400 VBZ denotes inhibits
T323 401-411 JJ denotes transgenic
T325 412-415 NN denotes APP
T324 416-426 NN denotes expression
T326 427-429 IN denotes by
T327 430-437 JJR denotes greater
T329 438-442 IN denotes than
T328 443-445 CD denotes 95
T330 445-446 NN denotes %
T331 447-450 CC denotes and
T332 451-458 VBZ denotes reduces
T333 459-461 NN denotes Aβ
T334 462-472 NN denotes production
T335 473-475 IN denotes to
T336 476-482 NNS denotes levels
T337 483-488 VBN denotes found
T338 489-491 IN denotes in
T339 492-505 JJ denotes nontransgenic
T340 506-510 NNS denotes mice
T341 510-511 . denotes .
T342 511-617 sentence denotes Suppression of transgenic Aβ synthesis in this model abruptly halts the progression of amyloid pathology.
T343 512-523 NN denotes Suppression
T345 524-526 IN denotes of
T346 527-537 JJ denotes transgenic
T348 538-540 NN denotes Aβ
T347 541-550 NN denotes synthesis
T349 551-553 IN denotes in
T350 554-558 DT denotes this
T351 559-564 NN denotes model
T352 565-573 RB denotes abruptly
T344 574-579 VBZ denotes halts
T353 580-583 DT denotes the
T354 584-595 NN denotes progression
T355 596-598 IN denotes of
T356 599-606 NN denotes amyloid
T357 607-616 NN denotes pathology
T358 616-617 . denotes .
T359 617-770 sentence denotes However, formation and disaggregation of amyloid deposits appear to be in disequilibrium as the plaques require far longer to disperse than to assemble.
T360 618-625 RB denotes However
T362 625-627 , denotes ,
T363 627-636 NN denotes formation
T364 637-640 CC denotes and
T365 641-655 NN denotes disaggregation
T366 656-658 IN denotes of
T367 659-666 NN denotes amyloid
T368 667-675 NNS denotes deposits
T361 676-682 VBP denotes appear
T369 683-685 TO denotes to
T370 686-688 VB denotes be
T371 689-691 IN denotes in
T372 692-706 NN denotes disequilibrium
T373 707-709 IN denotes as
T375 710-713 DT denotes the
T376 714-721 NNS denotes plaques
T374 722-729 VBP denotes require
T377 730-733 RB denotes far
T378 734-740 RBR denotes longer
T379 741-743 TO denotes to
T380 744-752 VB denotes disperse
T381 753-757 IN denotes than
T383 758-760 TO denotes to
T382 761-769 VB denotes assemble
T384 769-770 . denotes .
T385 770-942 sentence denotes Mice in which APP synthesis was suppressed for as long as 6 mo after the formation of Aβ deposits retain a considerable amyloid load, with little sign of active clearance.
T386 771-775 NNS denotes Mice
T388 776-778 IN denotes in
T390 779-784 WDT denotes which
T391 785-788 NN denotes APP
T392 789-798 NN denotes synthesis
T393 799-802 VBD denotes was
T389 803-813 VBN denotes suppressed
T394 814-817 IN denotes for
T395 818-820 RB denotes as
T397 821-825 JJ denotes long
T398 826-828 IN denotes as
T396 829-830 CD denotes 6
T399 831-833 NN denotes mo
T400 834-839 IN denotes after
T401 840-843 DT denotes the
T402 844-853 NN denotes formation
T403 854-856 IN denotes of
T404 857-859 NN denotes Aβ
T405 860-868 NNS denotes deposits
T387 869-875 VBP denotes retain
T406 876-877 DT denotes a
T408 878-890 JJ denotes considerable
T409 891-898 NN denotes amyloid
T407 899-903 NN denotes load
T410 903-905 , denotes ,
T411 905-909 IN denotes with
T412 910-916 JJ denotes little
T413 917-921 NN denotes sign
T414 922-924 IN denotes of
T415 925-931 JJ denotes active
T416 932-941 NN denotes clearance
T417 941-942 . denotes .
R110 T258 T257 cc and,Methods
R111 T259 T257 conj Findings,Methods
R112 T261 T262 nsubj We,generated
R113 T263 T262 aux have,generated
R114 T264 T265 det a,model
R115 T265 T262 dobj model,generated
R116 T266 T265 amod transgenic,model
R117 T267 T265 compound mouse,model
R118 T268 T269 dep that,mimics
R119 T269 T265 relcl mimics,model
R120 T270 T269 advmod genetically,mimics
R121 T271 T272 det the,arrest
R122 T272 T269 dobj arrest,mimics
R123 T273 T272 prep of,arrest
R124 T274 T275 compound Aβ,production
R125 T275 T273 pobj production,of
R126 T276 T275 acl expected,production
R127 T277 T276 prep from,expected
R128 T278 T277 pobj treatment,from
R129 T279 T278 prep with,treatment
R130 T280 T281 compound secretase,inhibitors
R131 T281 T279 pobj inhibitors,with
R132 T282 T262 punct .,generated
R133 T284 T285 det These,mice
R134 T285 T286 nsubj mice,overexpress
R135 T287 T288 compound mutant,APP
R136 T288 T286 dobj APP,overexpress
R137 T289 T286 prep from,overexpress
R138 T290 T291 det a,vector
R139 T291 T289 pobj vector,from
R140 T292 T293 dep that,regulated
R141 T293 T291 relcl regulated,vector
R142 T294 T293 aux can,regulated
R143 T295 T293 auxpass be,regulated
R144 T296 T293 agent by,regulated
R145 T297 T296 pobj doxycycline,by
R146 T298 T286 punct .,overexpress
R147 T300 T301 prep Under,induces
R148 T302 T303 amod normal,conditions
R149 T303 T300 pobj conditions,Under
R150 T304 T301 punct ", ",induces
R151 T305 T306 amod high,level
R152 T306 T308 compound level,expression
R153 T307 T306 punct -,level
R154 T308 T301 nsubj expression,induces
R155 T309 T308 prep of,expression
R156 T310 T309 pobj APP,of
R157 T311 T301 advmod quickly,induces
R158 T312 T313 amod fulminant,pathology
R159 T313 T301 dobj pathology,induces
R160 T314 T313 compound amyloid,pathology
R161 T315 T301 punct .,induces
R162 T317 T318 nsubj We,show
R163 T319 T320 mark that,inhibits
R164 T320 T318 ccomp inhibits,show
R165 T321 T322 compound doxycycline,administration
R166 T322 T320 nsubj administration,inhibits
R167 T323 T324 amod transgenic,expression
R168 T324 T320 dobj expression,inhibits
R169 T325 T324 compound APP,expression
R170 T326 T320 prep by,inhibits
R171 T327 T328 amod greater,95
R172 T328 T330 nummod 95,%
R173 T329 T328 quantmod than,95
R174 T330 T326 pobj %,by
R175 T331 T320 cc and,inhibits
R176 T332 T320 conj reduces,inhibits
R177 T333 T334 compound Aβ,production
R178 T334 T332 dobj production,reduces
R179 T335 T332 prep to,reduces
R180 T336 T335 pobj levels,to
R181 T337 T336 acl found,levels
R182 T338 T337 prep in,found
R183 T339 T340 amod nontransgenic,mice
R184 T340 T338 pobj mice,in
R185 T341 T318 punct .,show
R186 T343 T344 nsubj Suppression,halts
R187 T345 T343 prep of,Suppression
R188 T346 T347 amod transgenic,synthesis
R189 T347 T345 pobj synthesis,of
R190 T348 T347 compound Aβ,synthesis
R191 T349 T343 prep in,Suppression
R192 T350 T351 det this,model
R193 T351 T349 pobj model,in
R194 T352 T344 advmod abruptly,halts
R195 T353 T354 det the,progression
R196 T354 T344 dobj progression,halts
R197 T355 T354 prep of,progression
R198 T356 T357 compound amyloid,pathology
R199 T357 T355 pobj pathology,of
R200 T358 T344 punct .,halts
R201 T360 T361 advmod However,appear
R202 T362 T361 punct ", ",appear
R203 T363 T361 nsubj formation,appear
R204 T364 T363 cc and,formation
R205 T365 T363 conj disaggregation,formation
R206 T366 T363 prep of,formation
R207 T367 T368 compound amyloid,deposits
R208 T368 T366 pobj deposits,of
R209 T369 T370 aux to,be
R210 T370 T361 xcomp be,appear
R211 T371 T370 prep in,be
R212 T372 T371 pobj disequilibrium,in
R213 T373 T374 mark as,require
R214 T374 T370 advcl require,be
R215 T375 T376 det the,plaques
R216 T376 T374 nsubj plaques,require
R217 T377 T378 advmod far,longer
R218 T378 T374 advmod longer,require
R219 T379 T380 aux to,disperse
R220 T380 T374 xcomp disperse,require
R221 T381 T382 mark than,assemble
R222 T382 T374 advcl assemble,require
R223 T383 T382 aux to,assemble
R224 T384 T361 punct .,appear
R225 T386 T387 nsubj Mice,retain
R226 T388 T389 prep in,suppressed
R227 T389 T386 relcl suppressed,Mice
R228 T390 T388 pobj which,in
R229 T391 T392 compound APP,synthesis
R230 T392 T389 nsubjpass synthesis,suppressed
R231 T393 T389 auxpass was,suppressed
R232 T394 T389 prep for,suppressed
R233 T395 T396 advmod as,6
R234 T396 T399 nummod 6,mo
R235 T397 T396 amod long,6
R236 T398 T396 quantmod as,6
R237 T399 T394 pobj mo,for
R238 T400 T389 prep after,suppressed
R239 T401 T402 det the,formation
R240 T402 T400 pobj formation,after
R241 T403 T402 prep of,formation
R242 T404 T405 compound Aβ,deposits
R243 T405 T403 pobj deposits,of
R244 T406 T407 det a,load
R245 T407 T387 dobj load,retain
R246 T408 T407 amod considerable,load
R247 T409 T407 compound amyloid,load
R248 T410 T387 punct ", ",retain
R249 T411 T387 prep with,retain
R250 T412 T413 amod little,sign
R251 T413 T411 pobj sign,with
R252 T414 T413 prep of,sign
R253 T415 T416 amod active,clearance
R254 T416 T414 pobj clearance,of
R255 T417 T387 punct .,retain