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PMC:1283364 / 58351-59321 JSONTXT 5 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T12400 0-9 NNP denotes SantaCruz
T12402 10-12 FW denotes et
T12403 13-16 FW denotes al.
T12404 17-25 RB denotes recently
T12401 26-35 VBD denotes published
T12405 36-37 DT denotes a
T12406 38-43 NN denotes study
T12407 44-46 IN denotes of
T12408 47-51 NNS denotes mice
T12409 52-56 WDT denotes that
T12410 57-64 VBP denotes express
T12411 65-70 NN denotes P301L
T12413 71-76 JJ denotes human
T12412 77-80 NN denotes tau
T12414 81-84 IN denotes via
T12415 85-86 DT denotes a
T12417 87-94 JJ denotes similar
T12418 95-101 NN denotes vector
T12416 102-108 NN denotes system
T12419 109-110 -LRB- denotes [
T12420 110-112 CD denotes 61
T12421 112-113 -RRB- denotes ]
T12422 113-114 . denotes .
T12423 114-282 sentence denotes As in our tet-off APP mice, SantaCruz et al. found that tau neurofibrillary tangles, like amyloid plaques, are not cleared efficiently following transgene suppression.
T12424 115-117 IN denotes As
T12426 118-120 IN denotes in
T12427 121-124 PRP$ denotes our
T12429 125-128 NN denotes tet
T12431 128-129 HYPH denotes -
T12430 129-132 NN denotes off
T12432 133-136 NN denotes APP
T12428 137-141 NNS denotes mice
T12433 141-143 , denotes ,
T12434 143-152 NNP denotes SantaCruz
T12435 153-155 FW denotes et
T12436 156-159 FW denotes al.
T12425 160-165 VBD denotes found
T12437 166-170 IN denotes that
T12439 171-174 NN denotes tau
T12441 175-190 JJ denotes neurofibrillary
T12440 191-198 NNS denotes tangles
T12442 198-200 , denotes ,
T12443 200-204 IN denotes like
T12444 205-212 NN denotes amyloid
T12445 213-220 NNS denotes plaques
T12446 220-222 , denotes ,
T12447 222-225 VBP denotes are
T12448 226-229 RB denotes not
T12438 230-237 VBN denotes cleared
T12449 238-249 RB denotes efficiently
T12450 250-259 VBG denotes following
T12451 260-269 NN denotes transgene
T12452 270-281 NN denotes suppression
T12453 281-282 . denotes .
T12454 282-485 sentence denotes The lack of clearance in both models of AD pathology comes as a stark contrast to the rapid removal of protein aggregates found in similar tet-off mouse models of Huntington [32] and prion disease [62].
T12455 283-286 DT denotes The
T12456 287-291 NN denotes lack
T12458 292-294 IN denotes of
T12459 295-304 NN denotes clearance
T12460 305-307 IN denotes in
T12461 308-312 DT denotes both
T12462 313-319 NNS denotes models
T12463 320-322 IN denotes of
T12464 323-325 NN denotes AD
T12465 326-335 NN denotes pathology
T12457 336-341 VBZ denotes comes
T12466 342-344 IN denotes as
T12467 345-346 DT denotes a
T12469 347-352 JJ denotes stark
T12468 353-361 NN denotes contrast
T12470 362-364 IN denotes to
T12471 365-368 DT denotes the
T12473 369-374 JJ denotes rapid
T12472 375-382 NN denotes removal
T12474 383-385 IN denotes of
T12475 386-393 NN denotes protein
T12476 394-404 NNS denotes aggregates
T12477 405-410 VBN denotes found
T12478 411-413 IN denotes in
T12479 414-421 JJ denotes similar
T12481 422-425 NN denotes tet
T12483 425-426 HYPH denotes -
T12482 426-429 NN denotes off
T12484 430-435 NN denotes mouse
T12480 436-442 NNS denotes models
T12485 443-445 IN denotes of
T12486 446-456 NNP denotes Huntington
T12488 457-458 -LRB- denotes [
T12489 458-460 CD denotes 32
T12490 460-461 -RRB- denotes ]
T12491 462-465 CC denotes and
T12492 466-471 NN denotes prion
T12487 472-479 NN denotes disease
T12493 480-481 -LRB- denotes [
T12494 481-483 CD denotes 62
T12495 483-484 -RRB- denotes ]
T12496 484-485 . denotes .
T12497 485-647 sentence denotes In these cases, disrupting the input of new monomer to the system via dox-mediated transgene suppression led to relatively rapid clearance of protein aggregates.
T12498 486-488 IN denotes In
T12500 489-494 DT denotes these
T12501 495-500 NNS denotes cases
T12502 500-502 , denotes ,
T12503 502-512 VBG denotes disrupting
T12504 513-516 DT denotes the
T12505 517-522 NN denotes input
T12506 523-525 IN denotes of
T12507 526-529 JJ denotes new
T12508 530-537 NN denotes monomer
T12509 538-540 IN denotes to
T12510 541-544 DT denotes the
T12511 545-551 NN denotes system
T12512 552-555 IN denotes via
T12513 556-559 NN denotes dox
T12515 559-560 HYPH denotes -
T12514 560-568 VBN denotes mediated
T12517 569-578 NN denotes transgene
T12516 579-590 NN denotes suppression
T12499 591-594 VBD denotes led
T12518 595-597 IN denotes to
T12519 598-608 RB denotes relatively
T12520 609-614 JJ denotes rapid
T12521 615-624 NN denotes clearance
T12522 625-627 IN denotes of
T12523 628-635 NN denotes protein
T12524 636-646 NNS denotes aggregates
T12525 646-647 . denotes .
T12526 647-802 sentence denotes By contrast, our study and that of SantaCruz et al. suggest that protein aggregates in AD may be more tenacious than in other neurodegenerative disorders.
T12527 648-650 IN denotes By
T12529 651-659 NN denotes contrast
T12530 659-661 , denotes ,
T12531 661-664 PRP$ denotes our
T12532 665-670 NN denotes study
T12533 671-674 CC denotes and
T12534 675-679 DT denotes that
T12535 680-682 IN denotes of
T12536 683-692 NNP denotes SantaCruz
T12537 693-695 FW denotes et
T12538 696-699 FW denotes al.
T12528 700-707 VBP denotes suggest
T12539 708-712 IN denotes that
T12541 713-720 NN denotes protein
T12542 721-731 NNS denotes aggregates
T12543 732-734 IN denotes in
T12544 735-737 NN denotes AD
T12545 738-741 MD denotes may
T12540 742-744 VB denotes be
T12546 745-749 RBR denotes more
T12547 750-759 JJ denotes tenacious
T12548 760-764 IN denotes than
T12549 765-767 IN denotes in
T12550 768-773 JJ denotes other
T12552 774-791 JJ denotes neurodegenerative
T12551 792-801 NNS denotes disorders
T12553 801-802 . denotes .
T12554 802-970 sentence denotes Perhaps once aggregated, Aβ and tau are either inherently more stable than other protein aggregates or more resistant to intra- and extracellular clearance mechanisms.
T12555 803-810 RB denotes Perhaps
T12557 811-815 IN denotes once
T12558 816-826 VBN denotes aggregated
T12559 826-828 , denotes ,
T12560 828-830 NN denotes Aβ
T12561 831-834 CC denotes and
T12562 835-838 NN denotes tau
T12556 839-842 VBP denotes are
T12563 843-849 RB denotes either
T12565 850-860 RB denotes inherently
T12566 861-865 RBR denotes more
T12564 866-872 JJ denotes stable
T12567 873-877 IN denotes than
T12568 878-883 JJ denotes other
T12570 884-891 NN denotes protein
T12569 892-902 NNS denotes aggregates
T12571 903-905 CC denotes or
T12572 906-910 RBR denotes more
T12573 911-920 JJ denotes resistant
T12574 921-923 IN denotes to
T12575 924-929 AFX denotes intra
T12577 929-930 HYPH denotes -
T12578 931-934 CC denotes and
T12576 935-948 JJ denotes extracellular
T12580 949-958 NN denotes clearance
T12579 959-969 NNS denotes mechanisms
T12581 969-970 . denotes .
R8684 T12400 T12401 nsubj SantaCruz,published
R8686 T12402 T12403 advmod et,al.
R8687 T12403 T12400 advmod al.,SantaCruz
R8691 T12404 T12401 advmod recently,published
R8693 T12405 T12406 det a,study
R8694 T12406 T12401 dobj study,published
R8695 T12407 T12406 prep of,study
R8696 T12408 T12407 pobj mice,of
R8697 T12409 T12410 dep that,express
R8698 T12410 T12408 relcl express,mice
R8700 T12411 T12412 nmod P301L,tau
R8701 T12412 T12410 dobj tau,express
R8703 T12413 T12412 amod human,tau
R8704 T12414 T12410 prep via,express
R8705 T12415 T12416 det a,system
R8707 T12416 T12414 pobj system,via
R8708 T12417 T12416 amod similar,system
R8710 T12418 T12416 compound vector,system
R8711 T12419 T12420 punct [,61
R8712 T12420 T12401 parataxis 61,published
R8714 T12421 T12420 punct ],61
R8715 T12422 T12401 punct .,published
R8717 T12424 T12425 prep As,found
R8719 T12426 T12424 prep in,As
R8720 T12427 T12428 poss our,mice
R8723 T12428 T12426 pobj mice,in
R8724 T12429 T12430 compound tet,off
R8726 T12430 T12428 compound off,mice
R8727 T12431 T12430 punct -,off
R8729 T12432 T12428 compound APP,mice
R8730 T12433 T12425 punct ", ",found
R8731 T12434 T12425 nsubj SantaCruz,found
R8733 T12435 T12436 advmod et,al.
R8734 T12436 T12434 advmod al.,SantaCruz
R8735 T12437 T12438 mark that,cleared
R8737 T12438 T12425 ccomp cleared,found
R8738 T12439 T12440 nmod tau,tangles
R8740 T12440 T12438 nsubjpass tangles,cleared
R8741 T12441 T12440 amod neurofibrillary,tangles
R8743 T12442 T12440 punct ", ",tangles
R8744 T12443 T12440 prep like,tangles
R8745 T12444 T12445 compound amyloid,plaques
R8746 T12445 T12443 pobj plaques,like
R8747 T12446 T12438 punct ", ",cleared
R8749 T12447 T12438 auxpass are,cleared
R8750 T12448 T12438 neg not,cleared
R8751 T12449 T12438 advmod efficiently,cleared
R8752 T12450 T12438 prep following,cleared
R8754 T12451 T12452 compound transgene,suppression
R8755 T12452 T12450 pobj suppression,following
R8756 T12453 T12425 punct .,found
R8758 T12455 T12456 det The,lack
R8759 T12456 T12457 nsubj lack,comes
R8761 T12458 T12456 prep of,lack
R8763 T12459 T12458 pobj clearance,of
R8764 T12460 T12456 prep in,lack
R8765 T12461 T12462 det both,models
R8767 T12462 T12460 pobj models,in
R8768 T12463 T12462 prep of,models
R8770 T12464 T12465 compound AD,pathology
R8771 T12465 T12463 pobj pathology,of
R8772 T12466 T12457 prep as,comes
R8774 T12467 T12468 det a,contrast
R8775 T12468 T12466 pobj contrast,as
R8777 T12469 T12468 amod stark,contrast
R8778 T12470 T12468 prep to,contrast
R8779 T12471 T12472 det the,removal
R8781 T12472 T12470 pobj removal,to
R8782 T12473 T12472 amod rapid,removal
R8784 T12474 T12472 prep of,removal
R8785 T12475 T12476 compound protein,aggregates
R8786 T12476 T12474 pobj aggregates,of
R8788 T12477 T12472 acl found,removal
R8789 T12478 T12477 prep in,found
R8790 T12479 T12480 amod similar,models
R8792 T12480 T12478 pobj models,in
R8793 T12481 T12482 compound tet,off
R8795 T12482 T12480 compound off,models
R8796 T12483 T12482 punct -,off
R8797 T12484 T12480 compound mouse,models
R8798 T12485 T12480 prep of,models
R8799 T12486 T12487 nmod Huntington,disease
R8800 T12487 T12485 pobj disease,of
R8802 T12488 T12489 punct [,32
R8803 T12489 T12486 parataxis 32,Huntington
R8804 T12490 T12489 punct ],32
R8806 T12491 T12486 cc and,Huntington
R8807 T12492 T12486 conj prion,Huntington
R8808 T12493 T12494 punct [,62
R8810 T12494 T12487 parataxis 62,disease
R8811 T12495 T12494 punct ],62
R8813 T12496 T12457 punct .,comes
R8814 T12498 T12499 prep In,led
R8816 T12500 T12501 det these,cases
R8817 T12501 T12498 pobj cases,In
R8818 T12502 T12499 punct ", ",led
R8819 T12503 T12499 csubj disrupting,led
R8821 T12504 T12505 det the,input
R8822 T12505 T12503 dobj input,disrupting
R8823 T12506 T12505 prep of,input
R8825 T12507 T12508 amod new,monomer
R8826 T12508 T12506 pobj monomer,of
R8827 T12509 T12505 prep to,input
R8832 T12510 T12511 det the,system
R8834 T12511 T12509 pobj system,to
R8835 T12512 T12503 prep via,disrupting
R8836 T12513 T12514 npadvmod dox,mediated
R8839 T12514 T12516 amod mediated,suppression
R8841 T12515 T12514 punct -,mediated
R8842 T12516 T12512 pobj suppression,via
R8843 T12517 T12516 compound transgene,suppression
R8845 T12518 T12499 prep to,led
R8846 T12519 T12520 advmod relatively,rapid
R8848 T12520 T12521 amod rapid,clearance
R8849 T12521 T12518 pobj clearance,to
R8850 T12522 T12521 prep of,clearance
R8851 T12523 T12524 compound protein,aggregates
R8853 T12524 T12522 pobj aggregates,of
R8854 T12525 T12499 punct .,led
R8856 T12527 T12528 prep By,suggest
R8857 T12529 T12527 pobj contrast,By
R8859 T12530 T12528 punct ", ",suggest
R8860 T12531 T12532 poss our,study
R8861 T12532 T12528 nsubj study,suggest
R8863 T12533 T12532 cc and,study
R8864 T12534 T12532 conj that,study
R8865 T12535 T12534 prep of,that
R8867 T12536 T12535 pobj SantaCruz,of
R8868 T12537 T12538 advmod et,al.
R8869 T12538 T12536 advmod al.,SantaCruz
R8871 T12539 T12540 mark that,be
R8872 T12540 T12528 ccomp be,suggest
R8873 T12541 T12542 compound protein,aggregates
R8875 T12542 T12540 nsubj aggregates,be
R8876 T12543 T12542 prep in,aggregates
R8878 T12544 T12543 pobj AD,in
R8879 T12545 T12540 aux may,be
R8880 T12546 T12547 advmod more,tenacious
R8882 T12547 T12540 acomp tenacious,be
R8883 T12548 T12547 prep than,tenacious
R8884 T12549 T12548 prep in,than
R8886 T12550 T12551 amod other,disorders
R8887 T12551 T12549 pobj disorders,in
R8889 T12552 T12551 amod neurodegenerative,disorders
R8890 T12553 T12528 punct .,suggest
R8892 T12555 T12556 advmod Perhaps,are
R8894 T12557 T12558 mark once,aggregated
R8895 T12558 T12556 advcl aggregated,are
R8897 T12559 T12556 punct ", ",are
R8898 T12560 T12556 nsubj Aβ,are
R8899 T12561 T12560 cc and,Aβ
R8901 T12562 T12560 conj tau,Aβ
R8902 T12563 T12564 advmod either,stable
R8903 T12564 T12556 acomp stable,are
R8904 T12565 T12564 advmod inherently,stable
R8905 T12566 T12564 advmod more,stable
R8907 T12567 T12564 prep than,stable
R8908 T12568 T12569 amod other,aggregates
R8909 T12569 T12567 pobj aggregates,than
R8911 T12570 T12569 compound protein,aggregates
R8912 T12571 T12564 cc or,stable
R8913 T12572 T12573 advmod more,resistant
R8915 T12573 T12564 conj resistant,stable
R8916 T12574 T12573 prep to,resistant
R8917 T12575 T12576 advmod intra,extracellular
R8919 T12576 T12579 amod extracellular,mechanisms
R8920 T12577 T12576 punct -,extracellular
R8922 T12578 T12576 cc and,extracellular
R8923 T12579 T12574 pobj mechanisms,to
R8924 T12580 T12579 compound clearance,mechanisms
R8926 T12581 T12556 punct .,are