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PMC:1283364 / 39096-40059 JSONTXT 5 Projects

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Id Subject Object Predicate Lexical cue
T8616 0-2 PRP denotes We
T8618 3-16 RB denotes biochemically
T8617 17-25 VBD denotes measured
T8619 26-29 DT denotes the
T8620 30-36 NN denotes amount
T8621 37-39 IN denotes of
T8622 40-50 VBN denotes aggregated
T8623 51-53 NN denotes Aβ
T8624 54-56 IN denotes in
T8625 57-60 DT denotes the
T8626 61-67 NNS denotes brains
T8627 68-70 IN denotes of
T8628 71-74 PRP$ denotes our
T8629 75-79 NNS denotes mice
T8630 80-86 IN denotes before
T8631 87-90 CC denotes and
T8632 91-96 IN denotes after
T8633 97-106 NN denotes transgene
T8634 107-118 NN denotes suppression
T8635 119-124 VBG denotes using
T8636 125-131 NN denotes filter
T8637 132-136 NN denotes trap
T8638 137-145 NN denotes analysis
T8639 146-148 IN denotes of
T8640 149-157 JJ denotes cortical
T8641 158-164 NN denotes tissue
T8642 165-169 IN denotes from
T8643 170-174 DT denotes each
T8644 175-181 NN denotes animal
T8645 181-182 . denotes .
T8646 182-405 sentence denotes In this assay, serial dilutions of protein homogenate are passed through a cellulose acetate filter; particles larger than the pore size of the filter become trapped in the membrane and are revealed by immunoblotting [22].
T8647 183-185 IN denotes In
T8649 186-190 DT denotes this
T8650 191-196 NN denotes assay
T8651 196-198 , denotes ,
T8652 198-204 JJ denotes serial
T8653 205-214 NNS denotes dilutions
T8654 215-217 IN denotes of
T8655 218-225 NN denotes protein
T8656 226-236 NN denotes homogenate
T8657 237-240 VBP denotes are
T8648 241-247 VBN denotes passed
T8659 248-255 IN denotes through
T8660 256-257 DT denotes a
T8662 258-267 NN denotes cellulose
T8663 268-275 NN denotes acetate
T8661 276-282 NN denotes filter
T8664 282-283 : denotes ;
T8665 284-293 NNS denotes particles
T8666 294-300 JJR denotes larger
T8667 301-305 IN denotes than
T8668 306-309 DT denotes the
T8670 310-314 NN denotes pore
T8669 315-319 NN denotes size
T8671 320-322 IN denotes of
T8672 323-326 DT denotes the
T8673 327-333 NN denotes filter
T8658 334-340 VBP denotes become
T8674 341-348 JJ denotes trapped
T8675 349-351 IN denotes in
T8676 352-355 DT denotes the
T8677 356-364 NN denotes membrane
T8678 365-368 CC denotes and
T8679 369-372 VBP denotes are
T8680 373-381 VBN denotes revealed
T8681 382-384 IN denotes by
T8682 385-399 NN denotes immunoblotting
T8683 400-401 -LRB- denotes [
T8684 401-403 CD denotes 22
T8685 403-404 -RRB- denotes ]
T8686 404-405 . denotes .
T8687 405-627 sentence denotes Consistent with our visual analysis of the histological sections, line 107 tTA/APP mice treated with dox for 3 or 6 mo had the same amount of aggregated Aβ as when they started treatment at 6 mo of age (Figure 4A and 4B).
T8688 406-416 JJ denotes Consistent
T8690 417-421 IN denotes with
T8691 422-425 PRP$ denotes our
T8693 426-432 JJ denotes visual
T8692 433-441 NN denotes analysis
T8694 442-444 IN denotes of
T8695 445-448 DT denotes the
T8697 449-461 JJ denotes histological
T8696 462-470 NNS denotes sections
T8698 470-472 , denotes ,
T8699 472-476 NN denotes line
T8701 477-480 CD denotes 107
T8702 481-484 NN denotes tTA
T8704 484-485 HYPH denotes /
T8703 485-488 NN denotes APP
T8700 489-493 NNS denotes mice
T8705 494-501 VBN denotes treated
T8706 502-506 IN denotes with
T8707 507-510 NN denotes dox
T8708 511-514 IN denotes for
T8709 515-516 CD denotes 3
T8711 517-519 CC denotes or
T8712 520-521 CD denotes 6
T8710 522-524 NN denotes mo
T8689 525-528 VBD denotes had
T8713 529-532 DT denotes the
T8715 533-537 JJ denotes same
T8714 538-544 NN denotes amount
T8716 545-547 IN denotes of
T8717 548-558 VBN denotes aggregated
T8718 559-561 NN denotes Aβ
T8719 562-564 IN denotes as
T8720 565-569 WRB denotes when
T8722 570-574 PRP denotes they
T8721 575-582 VBD denotes started
T8723 583-592 NN denotes treatment
T8724 593-595 IN denotes at
T8725 596-597 CD denotes 6
T8726 598-600 NN denotes mo
T8727 601-603 IN denotes of
T8728 604-607 NN denotes age
T8729 608-609 -LRB- denotes (
T8731 609-615 NN denotes Figure
T8730 616-618 NN denotes 4A
T8732 619-622 CC denotes and
T8733 623-625 NN denotes 4B
T8734 625-626 -RRB- denotes )
T8735 626-627 . denotes .
T8736 627-736 sentence denotes In contrast, untreated 9-mo-old mice had almost twice as much aggregated Aβ as either of the treated groups.
T8737 628-630 IN denotes In
T8739 631-639 NN denotes contrast
T8740 639-641 , denotes ,
T8741 641-650 JJ denotes untreated
T8743 651-652 CD denotes 9
T8745 652-653 HYPH denotes -
T8744 653-655 NN denotes mo
T8747 655-656 HYPH denotes -
T8746 656-659 JJ denotes old
T8742 660-664 NNS denotes mice
T8738 665-668 VBD denotes had
T8748 669-675 RB denotes almost
T8749 676-681 RB denotes twice
T8751 682-684 RB denotes as
T8750 685-689 JJ denotes much
T8753 690-700 VBN denotes aggregated
T8752 701-703 NN denotes Aβ
T8754 704-706 IN denotes as
T8755 707-713 DT denotes either
T8756 714-716 IN denotes of
T8757 717-720 DT denotes the
T8759 721-728 VBN denotes treated
T8758 729-735 NNS denotes groups
T8760 735-736 . denotes .
T8761 736-963 sentence denotes Filter trap analysis of line 18 tTA/APP mice yielded similar results: the increase in aggregated Aβ observed in untreated animals between 6 and 9 mo of age was completely arrested by transgene suppression (Figure S5C and S5D).
T8762 737-743 NN denotes Filter
T8764 744-748 NN denotes trap
T8763 749-757 NN denotes analysis
T8766 758-760 IN denotes of
T8767 761-765 NN denotes line
T8769 766-768 CD denotes 18
T8770 769-772 NN denotes tTA
T8772 772-773 HYPH denotes /
T8771 773-776 NN denotes APP
T8768 777-781 NNS denotes mice
T8765 782-789 VBD denotes yielded
T8774 790-797 JJ denotes similar
T8775 798-805 NNS denotes results
T8776 805-807 : denotes :
T8777 807-810 DT denotes the
T8778 811-819 NN denotes increase
T8779 820-822 IN denotes in
T8780 823-833 VBN denotes aggregated
T8781 834-836 NN denotes Aβ
T8782 837-845 VBN denotes observed
T8783 846-848 IN denotes in
T8784 849-858 JJ denotes untreated
T8785 859-866 NNS denotes animals
T8786 867-874 IN denotes between
T8787 875-876 CD denotes 6
T8789 877-880 CC denotes and
T8790 881-882 CD denotes 9
T8788 883-885 NN denotes mo
T8791 886-888 IN denotes of
T8792 889-892 NN denotes age
T8793 893-896 VBD denotes was
T8794 897-907 RB denotes completely
T8773 908-916 VBN denotes arrested
T8795 917-919 IN denotes by
T8796 920-929 NN denotes transgene
T8797 930-941 NN denotes suppression
T8798 942-943 -LRB- denotes (
T8800 943-949 NN denotes Figure
T8799 950-953 NN denotes S5C
T8801 954-957 CC denotes and
T8802 958-961 NN denotes S5D
T8803 961-962 -RRB- denotes )
T8804 962-963 . denotes .
R5885 T8616 T8617 nsubj We,measured
R5887 T8618 T8617 advmod biochemically,measured
R5888 T8619 T8620 det the,amount
R5890 T8620 T8617 dobj amount,measured
R5891 T8621 T8620 prep of,amount
R5892 T8622 T8623 amod aggregated,Aβ
R5893 T8623 T8621 pobj Aβ,of
R5895 T8624 T8617 prep in,measured
R5898 T8625 T8626 det the,brains
R5899 T8626 T8624 pobj brains,in
R5901 T8627 T8626 prep of,brains
R5902 T8628 T8629 poss our,mice
R5903 T8629 T8627 pobj mice,of
R5905 T8630 T8617 prep before,measured
R5906 T8631 T8630 cc and,before
R5908 T8632 T8630 conj after,before
R5909 T8633 T8634 compound transgene,suppression
R5911 T8634 T8632 pobj suppression,after
R5912 T8635 T8617 advcl using,measured
R5913 T8636 T8637 compound filter,trap
R5915 T8637 T8638 compound trap,analysis
R5916 T8638 T8635 dobj analysis,using
R5918 T8639 T8638 prep of,analysis
R5919 T8640 T8641 amod cortical,tissue
R5920 T8641 T8639 pobj tissue,of
R5922 T8642 T8641 prep from,tissue
R5923 T8643 T8644 det each,animal
R5924 T8644 T8642 pobj animal,from
R5926 T8645 T8617 punct .,measured
R5928 T8647 T8648 prep In,passed
R5929 T8648 T8658 ccomp passed,become
R5930 T8649 T8650 det this,assay
R5932 T8650 T8647 pobj assay,In
R5933 T8651 T8648 punct ", ",passed
R5935 T8652 T8653 amod serial,dilutions
R5936 T8653 T8648 nsubjpass dilutions,passed
R5937 T8654 T8653 prep of,dilutions
R5938 T8655 T8656 compound protein,homogenate
R5939 T8656 T8654 pobj homogenate,of
R5941 T8657 T8648 auxpass are,passed
R5942 T8659 T8648 prep through,passed
R5943 T8660 T8661 det a,filter
R5945 T8661 T8659 pobj filter,through
R5946 T8662 T8661 compound cellulose,filter
R5947 T8663 T8661 compound acetate,filter
R5948 T8664 T8658 punct ;,become
R5950 T8665 T8658 nsubj particles,become
R5951 T8666 T8665 amod larger,particles
R5953 T8667 T8666 prep than,larger
R5954 T8668 T8669 det the,size
R5956 T8669 T8667 pobj size,than
R5957 T8670 T8669 compound pore,size
R5959 T8671 T8669 prep of,size
R5960 T8672 T8673 det the,filter
R5961 T8673 T8671 pobj filter,of
R5963 T8674 T8658 acomp trapped,become
R5964 T8675 T8674 prep in,trapped
R5966 T8676 T8677 det the,membrane
R5967 T8677 T8675 pobj membrane,in
R5969 T8678 T8658 cc and,become
R5970 T8679 T8680 auxpass are,revealed
R5972 T8680 T8658 conj revealed,become
R5973 T8681 T8680 prep by,revealed
R5974 T8682 T8681 pobj immunoblotting,by
R5976 T8683 T8684 punct [,22
R5977 T8684 T8680 parataxis 22,revealed
R5979 T8685 T8684 punct ],22
R5980 T8686 T8658 punct .,become
R5982 T8688 T8689 advcl Consistent,had
R5984 T8690 T8688 prep with,Consistent
R5985 T8691 T8692 poss our,analysis
R5987 T8692 T8690 pobj analysis,with
R5988 T8693 T8692 amod visual,analysis
R5989 T8694 T8692 prep of,analysis
R5990 T8695 T8696 det the,sections
R5991 T8696 T8694 pobj sections,of
R5992 T8697 T8696 amod histological,sections
R5994 T8698 T8689 punct ", ",had
R5995 T8699 T8700 nmod line,mice
R5997 T8700 T8689 nsubj mice,had
R5998 T8701 T8699 nummod 107,line
R5999 T8702 T8703 compound tTA,APP
R6001 T8703 T8700 compound APP,mice
R6002 T8704 T8703 punct /,APP
R6004 T8705 T8700 acl treated,mice
R6005 T8706 T8705 prep with,treated
R6006 T8707 T8706 pobj dox,with
R6011 T8708 T8705 prep for,treated
R6012 T8709 T8710 nummod 3,mo
R6016 T8710 T8708 pobj mo,for
R6017 T8711 T8710 cc or,mo
R6018 T8712 T8710 nummod 6,mo
R6020 T8713 T8714 det the,amount
R6021 T8714 T8689 dobj amount,had
R6023 T8715 T8714 amod same,amount
R6024 T8716 T8714 prep of,amount
R6026 T8717 T8718 amod aggregated,Aβ
R6027 T8718 T8716 pobj Aβ,of
R6029 T8719 T8714 prep as,amount
R6030 T8720 T8721 advmod when,started
R6032 T8721 T8719 pcomp started,as
R6033 T8722 T8721 nsubj they,started
R6034 T8723 T8721 dobj treatment,started
R6036 T8724 T8721 prep at,started
R6037 T8725 T8726 nummod 6,mo
R6039 T8726 T8724 pobj mo,at
R6040 T8727 T8726 prep of,mo
R6041 T8728 T8727 pobj age,of
R6042 T8729 T8730 punct (,4A
R6043 T8730 T8689 parataxis 4A,had
R6045 T8731 T8730 compound Figure,4A
R6046 T8732 T8730 cc and,4A
R6047 T8733 T8730 conj 4B,4A
R6049 T8734 T8730 punct ),4A
R6050 T8735 T8689 punct .,had
R6052 T8737 T8738 prep In,had
R6054 T8739 T8737 pobj contrast,In
R6055 T8740 T8738 punct ", ",had
R6057 T8741 T8742 amod untreated,mice
R6058 T8742 T8738 nsubj mice,had
R6060 T8743 T8744 nummod 9,mo
R6061 T8744 T8746 npadvmod mo,old
R6062 T8745 T8744 punct -,mo
R6064 T8746 T8742 amod old,mice
R6065 T8747 T8746 punct -,old
R6067 T8748 T8749 advmod almost,twice
R6068 T8749 T8750 advmod twice,much
R6070 T8750 T8752 amod much,Aβ
R6071 T8751 T8750 advmod as,much
R6073 T8752 T8738 dobj Aβ,had
R6074 T8753 T8752 amod aggregated,Aβ
R6075 T8754 T8752 prep as,Aβ
R6077 T8755 T8754 pobj either,as
R6078 T8756 T8755 prep of,either
R6080 T8757 T8758 det the,groups
R6081 T8758 T8756 pobj groups,of
R6082 T8759 T8758 amod treated,groups
R6084 T8760 T8738 punct .,had
R6085 T8762 T8763 compound Filter,analysis
R6087 T8763 T8765 nsubj analysis,yielded
R6088 T8764 T8763 compound trap,analysis
R6089 T8765 T8773 ccomp yielded,arrested
R6091 T8766 T8763 prep of,analysis
R6092 T8767 T8768 nmod line,mice
R6093 T8768 T8766 pobj mice,of
R6094 T8769 T8767 nummod 18,line
R6096 T8770 T8771 compound tTA,APP
R6097 T8771 T8768 compound APP,mice
R6098 T8772 T8771 punct /,APP
R6100 T8774 T8775 amod similar,results
R6102 T8775 T8765 dobj results,yielded
R6103 T8776 T8773 punct : ,arrested
R6105 T8777 T8778 det the,increase
R6106 T8778 T8773 nsubjpass increase,arrested
R6108 T8779 T8778 prep in,increase
R6109 T8780 T8781 amod aggregated,Aβ
R6110 T8781 T8779 pobj Aβ,in
R6112 T8782 T8778 acl observed,increase
R6113 T8783 T8782 prep in,observed
R6115 T8784 T8785 amod untreated,animals
R6116 T8785 T8783 pobj animals,in
R6117 T8786 T8785 prep between,animals
R6119 T8787 T8788 nummod 6,mo
R6120 T8788 T8786 pobj mo,between
R6121 T8789 T8787 cc and,6
R6122 T8790 T8787 conj 9,6
R6124 T8791 T8788 prep of,mo
R6125 T8792 T8791 pobj age,of
R6126 T8793 T8773 auxpass was,arrested
R6128 T8794 T8773 advmod completely,arrested
R6131 T8795 T8773 agent by,arrested
R6132 T8796 T8797 compound transgene,suppression
R6134 T8797 T8795 pobj suppression,by
R6135 T8798 T8799 punct (,S5C
R6136 T8799 T8773 parataxis S5C,arrested
R6138 T8800 T8799 compound Figure,S5C
R6139 T8801 T8799 cc and,S5C
R6141 T8802 T8799 conj S5D,S5C
R6142 T8803 T8799 punct ),S5C
R6144 T8804 T8773 punct .,arrested