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PMC:1283364 / 23754-25129 JSONTXT 4 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T6723 0-11 RB denotes Importantly
T6725 11-13 , denotes ,
T6726 13-16 DT denotes all
T6728 17-21 CD denotes four
T6729 22-25 JJ denotes new
T6727 26-31 NNS denotes lines
T6730 32-34 IN denotes of
T6731 35-38 NN denotes tet
T6733 38-39 HYPH denotes -
T6732 39-42 NN denotes off
T6735 43-46 NN denotes APP
T6734 47-51 NNS denotes mice
T6724 52-58 VBD denotes showed
T6736 59-65 RB denotes nearly
T6737 66-74 JJ denotes complete
T6738 75-86 NN denotes suppression
T6739 87-89 IN denotes of
T6740 90-93 DT denotes the
T6741 94-103 NN denotes transgene
T6742 104-113 VBG denotes following
T6743 114-117 NN denotes dox
T6744 118-127 NN denotes treatment
T6745 128-129 -LRB- denotes (
T6746 129-136 NNS denotes Figures
T6747 137-138 CD denotes 1
T6748 139-142 CC denotes and
T6749 143-149 NN denotes Figure
T6750 150-152 NN denotes S1
T6751 152-153 -RRB- denotes )
T6752 153-154 . denotes .
T6753 154-337 sentence denotes We focused on one of the four lines, line 107, to examine in more detail the time dependence and extent of transgene suppression following either acute or chronic treatment with dox.
T6754 155-157 PRP denotes We
T6755 158-165 VBD denotes focused
T6756 166-168 IN denotes on
T6757 169-172 CD denotes one
T6758 173-175 IN denotes of
T6759 176-179 DT denotes the
T6761 180-184 CD denotes four
T6760 185-190 NNS denotes lines
T6762 190-192 , denotes ,
T6763 192-196 NN denotes line
T6764 197-200 CD denotes 107
T6765 200-202 , denotes ,
T6766 202-204 TO denotes to
T6767 205-212 VB denotes examine
T6768 213-215 IN denotes in
T6769 216-220 JJR denotes more
T6770 221-227 NN denotes detail
T6771 228-231 DT denotes the
T6773 232-236 NN denotes time
T6772 237-247 NN denotes dependence
T6774 248-251 CC denotes and
T6775 252-258 NN denotes extent
T6776 259-261 IN denotes of
T6777 262-271 NN denotes transgene
T6778 272-283 NN denotes suppression
T6779 284-293 VBG denotes following
T6780 294-300 CC denotes either
T6782 301-306 JJ denotes acute
T6783 307-309 CC denotes or
T6784 310-317 JJ denotes chronic
T6781 318-327 NN denotes treatment
T6785 328-332 IN denotes with
T6786 333-336 NN denotes dox
T6787 336-337 . denotes .
T6788 337-617 sentence denotes Two dox-treated groups were compared to two untreated groups: one group of mice was born and raised on dox, a second group was treated with dox for 2 wk starting at 1 mo of age (4 wk + 2 wk dox); two untreated groups kept on normal chow were harvested at either 4 or 6 wk of age.
T6789 338-341 CD denotes Two
T6791 342-345 NN denotes dox
T6793 345-346 HYPH denotes -
T6792 346-353 VBN denotes treated
T6790 354-360 NNS denotes groups
T6795 361-365 VBD denotes were
T6794 366-374 VBN denotes compared
T6797 375-377 IN denotes to
T6798 378-381 CD denotes two
T6800 382-391 JJ denotes untreated
T6799 392-398 NNS denotes groups
T6801 398-400 : denotes :
T6802 400-403 CD denotes one
T6803 404-409 NN denotes group
T6805 410-412 IN denotes of
T6806 413-417 NNS denotes mice
T6807 418-421 VBD denotes was
T6804 422-426 VBN denotes born
T6808 427-430 CC denotes and
T6809 431-437 VBN denotes raised
T6810 438-440 IN denotes on
T6811 441-444 NN denotes dox
T6812 444-446 , denotes ,
T6813 446-447 DT denotes a
T6815 448-454 JJ denotes second
T6814 455-460 NN denotes group
T6817 461-464 VBD denotes was
T6816 465-472 VBN denotes treated
T6818 473-477 IN denotes with
T6819 478-481 NN denotes dox
T6820 482-485 IN denotes for
T6821 486-487 CD denotes 2
T6822 488-490 NN denotes wk
T6823 491-499 VBG denotes starting
T6824 500-502 IN denotes at
T6825 503-504 CD denotes 1
T6826 505-507 NN denotes mo
T6827 508-510 IN denotes of
T6828 511-514 NN denotes age
T6829 515-516 -LRB- denotes (
T6831 516-517 CD denotes 4
T6830 518-520 NN denotes wk
T6832 521-522 SYM denotes +
T6833 523-524 CD denotes 2
T6834 525-527 NN denotes wk
T6835 528-531 NN denotes dox
T6836 531-532 -RRB- denotes )
T6837 532-533 : denotes ;
T6838 534-537 CD denotes two
T6840 538-547 JJ denotes untreated
T6839 548-554 NNS denotes groups
T6841 555-559 VBN denotes kept
T6842 560-562 IN denotes on
T6843 563-569 JJ denotes normal
T6844 570-574 NN denotes chow
T6845 575-579 VBD denotes were
T6796 580-589 VBN denotes harvested
T6846 590-592 IN denotes at
T6847 593-599 CC denotes either
T6848 600-601 CD denotes 4
T6850 602-604 CC denotes or
T6851 605-606 CD denotes 6
T6849 607-609 NN denotes wk
T6852 610-612 IN denotes of
T6853 613-616 NN denotes age
T6854 616-617 . denotes .
T6855 617-688 sentence denotes Animals born and raised on dox harbored no transgenic APP (Figure 1A).
T6856 618-625 NNS denotes Animals
T6858 626-630 VBN denotes born
T6859 631-634 CC denotes and
T6860 635-641 VBN denotes raised
T6861 642-644 IN denotes on
T6862 645-648 NN denotes dox
T6857 649-657 VBD denotes harbored
T6863 658-660 DT denotes no
T6865 661-671 JJ denotes transgenic
T6864 672-675 NN denotes APP
T6866 676-677 -LRB- denotes (
T6868 677-683 NN denotes Figure
T6867 684-686 NN denotes 1A
T6869 686-687 -RRB- denotes )
T6870 687-688 . denotes .
T6871 688-817 sentence denotes Following as little as 2 wk of dox treatment, transgenic APP expression was reduced by more than 95% compared to pre-dox levels.
T6872 689-698 VBG denotes Following
T6874 699-701 RB denotes as
T6876 702-708 JJ denotes little
T6877 709-711 IN denotes as
T6875 712-713 CD denotes 2
T6878 714-716 NN denotes wk
T6879 717-719 IN denotes of
T6880 720-723 NN denotes dox
T6881 724-733 NN denotes treatment
T6882 733-735 , denotes ,
T6883 735-745 JJ denotes transgenic
T6885 746-749 NN denotes APP
T6884 750-760 NN denotes expression
T6886 761-764 VBD denotes was
T6873 765-772 VBN denotes reduced
T6887 773-775 IN denotes by
T6888 776-780 JJR denotes more
T6890 781-785 IN denotes than
T6889 786-788 CD denotes 95
T6891 788-789 NN denotes %
T6892 790-798 VBN denotes compared
T6893 799-801 IN denotes to
T6894 802-809 JJ denotes pre-dox
T6895 810-816 NNS denotes levels
T6896 816-817 . denotes .
T6897 817-1056 sentence denotes The residual expression remaining in acutely treated mice represents less than 4% of the transgenic protein produced in the absence of dox (Figure 1C), and likely results from slight leakage at the level of transcription (data not shown).
T6898 818-821 DT denotes The
T6900 822-830 JJ denotes residual
T6899 831-841 NN denotes expression
T6902 842-851 VBG denotes remaining
T6903 852-854 IN denotes in
T6904 855-862 RB denotes acutely
T6905 863-870 VBN denotes treated
T6906 871-875 NNS denotes mice
T6901 876-886 VBZ denotes represents
T6907 887-891 JJR denotes less
T6909 892-896 IN denotes than
T6908 897-898 CD denotes 4
T6910 898-899 NN denotes %
T6911 900-902 IN denotes of
T6912 903-906 DT denotes the
T6914 907-917 JJ denotes transgenic
T6913 918-925 NN denotes protein
T6915 926-934 VBN denotes produced
T6916 935-937 IN denotes in
T6917 938-941 DT denotes the
T6918 942-949 NN denotes absence
T6919 950-952 IN denotes of
T6920 953-956 NN denotes dox
T6921 957-958 -LRB- denotes (
T6923 958-964 NN denotes Figure
T6922 965-967 NN denotes 1C
T6924 967-968 -RRB- denotes )
T6925 968-970 , denotes ,
T6926 970-973 CC denotes and
T6927 974-980 RB denotes likely
T6928 981-988 VBZ denotes results
T6929 989-993 IN denotes from
T6930 994-1000 JJ denotes slight
T6931 1001-1008 NN denotes leakage
T6932 1009-1011 IN denotes at
T6933 1012-1015 DT denotes the
T6934 1016-1021 NN denotes level
T6935 1022-1024 IN denotes of
T6936 1025-1038 NN denotes transcription
T6937 1039-1040 -LRB- denotes (
T6939 1040-1044 NNS denotes data
T6940 1045-1048 RB denotes not
T6938 1049-1054 VBN denotes shown
T6941 1054-1055 -RRB- denotes )
T6942 1055-1056 . denotes .
T6943 1056-1375 sentence denotes Importantly, the total amount of APP (endogenous plus transgenic) and related APLPs in both acute and chronically treated animals was statistically indistinguishable from that in nontransgenic mice (Figure 1D; statistical analyses for experiments throughout the study are presented in the accompanying figure legends).
T6944 1057-1068 RB denotes Importantly
T6946 1068-1070 , denotes ,
T6947 1070-1073 DT denotes the
T6949 1074-1079 JJ denotes total
T6948 1080-1086 NN denotes amount
T6950 1087-1089 IN denotes of
T6951 1090-1093 NN denotes APP
T6952 1094-1095 -LRB- denotes (
T6953 1095-1105 JJ denotes endogenous
T6954 1106-1110 CC denotes plus
T6955 1111-1121 JJ denotes transgenic
T6956 1121-1122 -RRB- denotes )
T6957 1123-1126 CC denotes and
T6958 1127-1134 JJ denotes related
T6959 1135-1140 NNS denotes APLPs
T6960 1141-1143 IN denotes in
T6961 1144-1148 CC denotes both
T6962 1149-1154 JJ denotes acute
T6964 1155-1158 CC denotes and
T6965 1159-1170 RB denotes chronically
T6966 1171-1178 VBN denotes treated
T6963 1179-1186 NNS denotes animals
T6945 1187-1190 VBD denotes was
T6967 1191-1204 RB denotes statistically
T6968 1205-1222 JJ denotes indistinguishable
T6969 1223-1227 IN denotes from
T6970 1228-1232 DT denotes that
T6971 1233-1235 IN denotes in
T6972 1236-1249 JJ denotes nontransgenic
T6973 1250-1254 NNS denotes mice
T6974 1255-1256 -LRB- denotes (
T6976 1256-1262 NN denotes Figure
T6975 1263-1265 NN denotes 1D
T6977 1265-1266 : denotes ;
T6978 1267-1278 JJ denotes statistical
T6979 1279-1287 NNS denotes analyses
T6981 1288-1291 IN denotes for
T6982 1292-1303 NNS denotes experiments
T6983 1304-1314 IN denotes throughout
T6984 1315-1318 DT denotes the
T6985 1319-1324 NN denotes study
T6986 1325-1328 VBP denotes are
T6980 1329-1338 VBN denotes presented
T6987 1339-1341 IN denotes in
T6988 1342-1345 DT denotes the
T6990 1346-1358 VBG denotes accompanying
T6991 1359-1365 NN denotes figure
T6989 1366-1373 NNS denotes legends
T6992 1373-1374 -RRB- denotes )
T6993 1374-1375 . denotes .
R4169 T6723 T6724 advmod Importantly,showed
R4170 T6725 T6724 punct ", ",showed
R4171 T6726 T6727 det all,lines
R4172 T6727 T6724 nsubj lines,showed
R4173 T6728 T6727 nummod four,lines
R4174 T6729 T6727 amod new,lines
R4175 T6730 T6727 prep of,lines
R4176 T6731 T6732 compound tet,off
R4177 T6732 T6734 compound off,mice
R4178 T6733 T6732 punct -,off
R4179 T6734 T6730 pobj mice,of
R4180 T6735 T6734 compound APP,mice
R4181 T6736 T6737 advmod nearly,complete
R4182 T6737 T6738 amod complete,suppression
R4183 T6738 T6724 dobj suppression,showed
R4184 T6739 T6738 prep of,suppression
R4185 T6740 T6741 det the,transgene
R4186 T6741 T6739 pobj transgene,of
R4187 T6742 T6724 prep following,showed
R4188 T6743 T6744 compound dox,treatment
R4189 T6744 T6742 pobj treatment,following
R4190 T6745 T6746 punct (,Figures
R4191 T6746 T6724 parataxis Figures,showed
R4192 T6747 T6746 nummod 1,Figures
R4193 T6748 T6746 cc and,Figures
R4194 T6749 T6750 compound Figure,S1
R4195 T6750 T6746 conj S1,Figures
R4196 T6751 T6746 punct ),Figures
R4197 T6752 T6724 punct .,showed
R4198 T6754 T6755 nsubj We,focused
R4199 T6756 T6755 prep on,focused
R4200 T6757 T6756 pobj one,on
R4201 T6758 T6757 prep of,one
R4202 T6759 T6760 det the,lines
R4203 T6760 T6758 pobj lines,of
R4204 T6761 T6760 nummod four,lines
R4205 T6762 T6757 punct ", ",one
R4206 T6763 T6757 appos line,one
R4207 T6764 T6763 nummod 107,line
R4208 T6765 T6755 punct ", ",focused
R4209 T6766 T6767 aux to,examine
R4210 T6767 T6755 advcl examine,focused
R4211 T6768 T6767 prep in,examine
R4212 T6769 T6770 amod more,detail
R4213 T6770 T6768 pobj detail,in
R4214 T6771 T6772 det the,dependence
R4215 T6772 T6767 dobj dependence,examine
R4216 T6773 T6772 compound time,dependence
R4217 T6774 T6772 cc and,dependence
R4218 T6775 T6772 conj extent,dependence
R4219 T6776 T6775 prep of,extent
R4220 T6777 T6778 compound transgene,suppression
R4221 T6778 T6776 pobj suppression,of
R4222 T6779 T6772 prep following,dependence
R4223 T6780 T6781 preconj either,treatment
R4224 T6781 T6779 pobj treatment,following
R4225 T6782 T6781 amod acute,treatment
R4226 T6783 T6782 cc or,acute
R4227 T6784 T6782 conj chronic,acute
R4228 T6785 T6781 prep with,treatment
R4229 T6786 T6785 pobj dox,with
R4230 T6787 T6755 punct .,focused
R4231 T6789 T6790 nummod Two,groups
R4232 T6790 T6794 nsubjpass groups,compared
R4233 T6791 T6792 npadvmod dox,treated
R4234 T6792 T6790 amod treated,groups
R4235 T6793 T6792 punct -,treated
R4236 T6794 T6796 ccomp compared,harvested
R4237 T6795 T6794 auxpass were,compared
R4238 T6797 T6794 prep to,compared
R4239 T6798 T6799 nummod two,groups
R4240 T6799 T6797 pobj groups,to
R4241 T6800 T6799 amod untreated,groups
R4242 T6801 T6796 punct : ,harvested
R4243 T6802 T6803 nummod one,group
R4244 T6803 T6804 nsubjpass group,born
R4245 T6804 T6796 ccomp born,harvested
R4246 T6805 T6803 prep of,group
R4247 T6806 T6805 pobj mice,of
R4248 T6807 T6804 auxpass was,born
R4249 T6808 T6804 cc and,born
R4250 T6809 T6804 conj raised,born
R4251 T6810 T6809 prep on,raised
R4252 T6811 T6810 pobj dox,on
R4253 T6812 T6796 punct ", ",harvested
R4254 T6813 T6814 det a,group
R4255 T6814 T6816 nsubjpass group,treated
R4256 T6815 T6814 amod second,group
R4257 T6816 T6796 ccomp treated,harvested
R4258 T6817 T6816 auxpass was,treated
R4259 T6818 T6816 prep with,treated
R4260 T6819 T6818 pobj dox,with
R4261 T6820 T6816 prep for,treated
R4262 T6821 T6822 nummod 2,wk
R4263 T6822 T6820 pobj wk,for
R4264 T6823 T6816 advcl starting,treated
R4265 T6824 T6823 prep at,starting
R4266 T6825 T6826 nummod 1,mo
R4267 T6826 T6824 pobj mo,at
R4268 T6827 T6826 prep of,mo
R4269 T6828 T6827 pobj age,of
R4270 T6829 T6830 punct (,wk
R4271 T6830 T6816 parataxis wk,treated
R4272 T6831 T6830 nummod 4,wk
R4273 T6832 T6830 punct +,wk
R4274 T6833 T6834 nummod 2,wk
R4275 T6834 T6835 compound wk,dox
R4276 T6835 T6830 appos dox,wk
R4277 T6836 T6830 punct ),wk
R4278 T6837 T6796 punct ;,harvested
R4279 T6838 T6839 nummod two,groups
R4280 T6839 T6796 nsubjpass groups,harvested
R4281 T6840 T6839 amod untreated,groups
R4282 T6841 T6839 acl kept,groups
R4283 T6842 T6841 prep on,kept
R4284 T6843 T6844 amod normal,chow
R4285 T6844 T6842 pobj chow,on
R4286 T6845 T6796 auxpass were,harvested
R4287 T6846 T6796 prep at,harvested
R4288 T6847 T6848 preconj either,4
R4289 T6848 T6849 nummod 4,wk
R4290 T6849 T6846 pobj wk,at
R4291 T6850 T6848 cc or,4
R4292 T6851 T6848 conj 6,4
R4293 T6852 T6849 prep of,wk
R4294 T6853 T6852 pobj age,of
R4295 T6854 T6796 punct .,harvested
R4296 T6856 T6857 nsubj Animals,harbored
R4297 T6858 T6856 acl born,Animals
R4298 T6859 T6858 cc and,born
R4299 T6860 T6858 conj raised,born
R4300 T6861 T6860 prep on,raised
R4301 T6862 T6861 pobj dox,on
R4302 T6863 T6864 det no,APP
R4303 T6864 T6857 dobj APP,harbored
R4304 T6865 T6864 amod transgenic,APP
R4305 T6866 T6867 punct (,1A
R4306 T6867 T6857 parataxis 1A,harbored
R4307 T6868 T6867 compound Figure,1A
R4308 T6869 T6867 punct ),1A
R4309 T6870 T6857 punct .,harbored
R4310 T6872 T6873 prep Following,reduced
R4311 T6874 T6875 advmod as,2
R4312 T6875 T6878 nummod 2,wk
R4313 T6876 T6875 amod little,2
R4314 T6877 T6875 quantmod as,2
R4315 T6878 T6872 pobj wk,Following
R4316 T6879 T6878 prep of,wk
R4317 T6880 T6881 compound dox,treatment
R4318 T6881 T6879 pobj treatment,of
R4319 T6882 T6873 punct ", ",reduced
R4320 T6883 T6884 amod transgenic,expression
R4321 T6884 T6873 nsubjpass expression,reduced
R4322 T6885 T6884 compound APP,expression
R4323 T6886 T6873 auxpass was,reduced
R4324 T6887 T6873 prep by,reduced
R4325 T6888 T6889 amod more,95
R4326 T6889 T6891 nummod 95,%
R4327 T6890 T6889 quantmod than,95
R4328 T6891 T6887 pobj %,by
R4329 T6892 T6873 prep compared,reduced
R4330 T6893 T6892 prep to,compared
R4331 T6894 T6895 amod pre-dox,levels
R4332 T6895 T6893 pobj levels,to
R4333 T6896 T6873 punct .,reduced
R4334 T6898 T6899 det The,expression
R4335 T6899 T6901 nsubj expression,represents
R4336 T6900 T6899 amod residual,expression
R4337 T6902 T6899 acl remaining,expression
R4338 T6903 T6902 prep in,remaining
R4339 T6904 T6905 advmod acutely,treated
R4340 T6905 T6906 amod treated,mice
R4341 T6906 T6903 pobj mice,in
R4342 T6907 T6908 amod less,4
R4343 T6908 T6910 nummod 4,%
R4344 T6909 T6908 quantmod than,4
R4345 T6910 T6901 dobj %,represents
R4346 T6911 T6910 prep of,%
R4347 T6912 T6913 det the,protein
R4348 T6913 T6911 pobj protein,of
R4349 T6914 T6913 amod transgenic,protein
R4350 T6915 T6913 acl produced,protein
R4351 T6916 T6915 prep in,produced
R4352 T6917 T6918 det the,absence
R4353 T6918 T6916 pobj absence,in
R4354 T6919 T6918 prep of,absence
R4355 T6920 T6919 pobj dox,of
R4356 T6921 T6922 punct (,1C
R4357 T6922 T6915 parataxis 1C,produced
R4358 T6923 T6922 compound Figure,1C
R4359 T6924 T6922 punct ),1C
R4360 T6925 T6901 punct ", ",represents
R4361 T6926 T6901 cc and,represents
R4362 T6927 T6928 advmod likely,results
R4363 T6928 T6901 conj results,represents
R4364 T6929 T6928 prep from,results
R4365 T6930 T6931 amod slight,leakage
R4366 T6931 T6929 pobj leakage,from
R4367 T6932 T6931 prep at,leakage
R4368 T6933 T6934 det the,level
R4369 T6934 T6932 pobj level,at
R4370 T6935 T6934 prep of,level
R4371 T6936 T6935 pobj transcription,of
R4372 T6937 T6938 punct (,shown
R4373 T6938 T6928 parataxis shown,results
R4374 T6939 T6938 nsubj data,shown
R4375 T6940 T6938 neg not,shown
R4376 T6941 T6938 punct ),shown
R4377 T6942 T6901 punct .,represents
R4378 T6944 T6945 advmod Importantly,was
R4379 T6946 T6945 punct ", ",was
R4380 T6947 T6948 det the,amount
R4381 T6948 T6945 nsubj amount,was
R4382 T6949 T6948 amod total,amount
R4383 T6950 T6948 prep of,amount
R4384 T6951 T6950 pobj APP,of
R4385 T6952 T6953 punct (,endogenous
R4386 T6953 T6951 parataxis endogenous,APP
R4387 T6954 T6953 cc plus,endogenous
R4388 T6955 T6953 conj transgenic,endogenous
R4389 T6956 T6953 punct ),endogenous
R4390 T6957 T6951 cc and,APP
R4391 T6958 T6959 amod related,APLPs
R4392 T6959 T6951 conj APLPs,APP
R4393 T6960 T6948 prep in,amount
R4394 T6961 T6962 preconj both,acute
R4395 T6962 T6963 amod acute,animals
R4396 T6963 T6960 pobj animals,in
R4397 T6964 T6962 cc and,acute
R4398 T6965 T6966 advmod chronically,treated
R4399 T6966 T6962 conj treated,acute
R4400 T6967 T6968 advmod statistically,indistinguishable
R4401 T6968 T6945 acomp indistinguishable,was
R4402 T6969 T6968 prep from,indistinguishable
R4403 T6970 T6969 pobj that,from
R4404 T6971 T6970 prep in,that
R4405 T6972 T6973 amod nontransgenic,mice
R4406 T6973 T6971 pobj mice,in
R4407 T6974 T6975 punct (,1D
R4408 T6975 T6945 parataxis 1D,was
R4409 T6976 T6975 compound Figure,1D
R4410 T6977 T6975 punct ;,1D
R4411 T6978 T6979 amod statistical,analyses
R4412 T6979 T6980 nsubjpass analyses,presented
R4413 T6980 T6975 ccomp presented,1D
R4414 T6981 T6979 prep for,analyses
R4415 T6982 T6981 pobj experiments,for
R4416 T6983 T6982 prep throughout,experiments
R4417 T6984 T6985 det the,study
R4418 T6985 T6983 pobj study,throughout
R4419 T6986 T6980 auxpass are,presented
R4420 T6987 T6980 prep in,presented
R4421 T6988 T6989 det the,legends
R4422 T6989 T6987 pobj legends,in
R4423 T6990 T6989 amod accompanying,legends
R4424 T6991 T6989 compound figure,legends
R4425 T6992 T6975 punct ),1D
R4426 T6993 T6945 punct .,was