Id |
Subject |
Object |
Predicate |
Lexical cue |
T2419 |
0-2 |
TO |
denotes |
To |
T2420 |
3-10 |
VB |
denotes |
explore |
T2422 |
11-14 |
DT |
denotes |
the |
T2423 |
15-19 |
NN |
denotes |
role |
T2424 |
20-22 |
IN |
denotes |
of |
T2425 |
23-27 |
JJ |
denotes |
fast |
T2427 |
28-38 |
JJ |
denotes |
excitatory |
T2426 |
39-56 |
NN |
denotes |
neurotransmission |
T2428 |
57-64 |
VBN |
denotes |
carried |
T2429 |
65-67 |
IN |
denotes |
by |
T2430 |
68-72 |
NN |
denotes |
GluR |
T2432 |
72-73 |
HYPH |
denotes |
- |
T2431 |
73-74 |
NN |
denotes |
B |
T2434 |
74-75 |
HYPH |
denotes |
- |
T2433 |
75-85 |
VBG |
denotes |
containing |
T2436 |
86-90 |
NN |
denotes |
AMPA |
T2435 |
91-99 |
NNS |
denotes |
channels |
T2437 |
100-102 |
IN |
denotes |
in |
T2438 |
103-112 |
JJ |
denotes |
olfactory |
T2439 |
113-122 |
NNS |
denotes |
processes |
T2440 |
122-124 |
, |
denotes |
, |
T2441 |
124-126 |
PRP |
denotes |
we |
T2442 |
127-132 |
RB |
denotes |
first |
T2421 |
133-141 |
VBD |
denotes |
analyzed |
T2443 |
142-146 |
NNS |
denotes |
mice |
T2444 |
147-151 |
WDT |
denotes |
that |
T2445 |
152-159 |
VBP |
denotes |
express |
T2446 |
160-164 |
NN |
denotes |
part |
T2447 |
165-167 |
IN |
denotes |
of |
T2448 |
168-171 |
DT |
denotes |
the |
T2450 |
172-176 |
NN |
denotes |
GluR |
T2452 |
176-177 |
HYPH |
denotes |
- |
T2451 |
177-178 |
NN |
denotes |
B |
T2449 |
179-189 |
NN |
denotes |
population |
T2453 |
190-192 |
IN |
denotes |
in |
T2454 |
193-194 |
DT |
denotes |
a |
T2456 |
195-196 |
NN |
denotes |
Q |
T2458 |
196-197 |
HYPH |
denotes |
/ |
T2457 |
197-198 |
NN |
denotes |
R |
T2459 |
199-203 |
NN |
denotes |
site |
T2461 |
203-204 |
HYPH |
denotes |
- |
T2460 |
204-212 |
JJ |
denotes |
unedited |
T2455 |
213-217 |
NN |
denotes |
form |
T2462 |
218-219 |
-LRB- |
denotes |
( |
T2464 |
219-225 |
NN |
denotes |
Figure |
T2463 |
226-228 |
NN |
denotes |
1A |
T2465 |
228-229 |
: |
denotes |
; |
T2466 |
230-236 |
VBN |
denotes |
termed |
T2467 |
237-238 |
`` |
denotes |
“ |
T2468 |
238-242 |
NN |
denotes |
GluR |
T2470 |
242-243 |
HYPH |
denotes |
- |
T2469 |
243-248 |
NN |
denotes |
BΔECS |
T2471 |
248-249 |
: |
denotes |
: |
T2472 |
249-251 |
NN |
denotes |
FB |
T2473 |
251-252 |
'' |
denotes |
” |
T2474 |
252-253 |
: |
denotes |
; |
T2475 |
254-257 |
VB |
denotes |
see |
T2476 |
258-262 |
RB |
denotes |
also |
T2477 |
263-264 |
-LRB- |
denotes |
[ |
T2478 |
264-266 |
CD |
denotes |
58 |
T2479 |
266-267 |
-RRB- |
denotes |
] |
T2480 |
267-268 |
-RRB- |
denotes |
) |
T2481 |
268-269 |
. |
denotes |
. |
T2482 |
269-604 |
sentence |
denotes |
These mice carry, in addition to a wild-type GluR-B allele, a gene-targeted GluR-Bneo allele in which the intronic sequence critical for GluR-B pre-mRNA editing at the Q/R site is replaced by a floxed TK-neo gene, which severely reduces splicing of the modified intron and hence attenuates the expression of the GluR-Bneo allele [60]. |
T2483 |
270-275 |
DT |
denotes |
These |
T2484 |
276-280 |
NNS |
denotes |
mice |
T2485 |
281-286 |
VBP |
denotes |
carry |
T2486 |
286-288 |
, |
denotes |
, |
T2487 |
288-290 |
IN |
denotes |
in |
T2488 |
291-299 |
NN |
denotes |
addition |
T2489 |
300-302 |
IN |
denotes |
to |
T2490 |
303-304 |
DT |
denotes |
a |
T2492 |
305-309 |
JJ |
denotes |
wild |
T2494 |
309-310 |
HYPH |
denotes |
- |
T2493 |
310-314 |
NN |
denotes |
type |
T2495 |
315-319 |
NN |
denotes |
GluR |
T2497 |
319-320 |
HYPH |
denotes |
- |
T2496 |
320-321 |
NN |
denotes |
B |
T2491 |
322-328 |
NN |
denotes |
allele |
T2498 |
328-330 |
, |
denotes |
, |
T2499 |
330-331 |
DT |
denotes |
a |
T2501 |
332-336 |
NN |
denotes |
gene |
T2503 |
336-337 |
HYPH |
denotes |
- |
T2502 |
337-345 |
VBN |
denotes |
targeted |
T2504 |
346-350 |
NN |
denotes |
GluR |
T2506 |
350-351 |
HYPH |
denotes |
- |
T2505 |
351-355 |
NN |
denotes |
Bneo |
T2500 |
356-362 |
NN |
denotes |
allele |
T2507 |
363-365 |
IN |
denotes |
in |
T2509 |
366-371 |
WDT |
denotes |
which |
T2510 |
372-375 |
DT |
denotes |
the |
T2512 |
376-384 |
JJ |
denotes |
intronic |
T2511 |
385-393 |
NN |
denotes |
sequence |
T2513 |
394-402 |
JJ |
denotes |
critical |
T2514 |
403-406 |
IN |
denotes |
for |
T2515 |
407-411 |
NN |
denotes |
GluR |
T2517 |
411-412 |
HYPH |
denotes |
- |
T2516 |
412-413 |
NN |
denotes |
B |
T2519 |
414-422 |
NN |
denotes |
pre-mRNA |
T2518 |
423-430 |
NN |
denotes |
editing |
T2520 |
431-433 |
IN |
denotes |
at |
T2521 |
434-437 |
DT |
denotes |
the |
T2523 |
438-439 |
NN |
denotes |
Q |
T2525 |
439-440 |
HYPH |
denotes |
/ |
T2524 |
440-441 |
NN |
denotes |
R |
T2522 |
442-446 |
NN |
denotes |
site |
T2526 |
447-449 |
VBZ |
denotes |
is |
T2508 |
450-458 |
VBN |
denotes |
replaced |
T2527 |
459-461 |
IN |
denotes |
by |
T2528 |
462-463 |
DT |
denotes |
a |
T2530 |
464-470 |
VBN |
denotes |
floxed |
T2531 |
471-473 |
NN |
denotes |
TK |
T2533 |
473-474 |
HYPH |
denotes |
- |
T2532 |
474-477 |
NN |
denotes |
neo |
T2529 |
478-482 |
NN |
denotes |
gene |
T2534 |
482-484 |
, |
denotes |
, |
T2535 |
484-489 |
WDT |
denotes |
which |
T2537 |
490-498 |
RB |
denotes |
severely |
T2536 |
499-506 |
VBZ |
denotes |
reduces |
T2538 |
507-515 |
NN |
denotes |
splicing |
T2539 |
516-518 |
IN |
denotes |
of |
T2540 |
519-522 |
DT |
denotes |
the |
T2542 |
523-531 |
VBN |
denotes |
modified |
T2541 |
532-538 |
NN |
denotes |
intron |
T2543 |
539-542 |
CC |
denotes |
and |
T2544 |
543-548 |
RB |
denotes |
hence |
T2545 |
549-559 |
VBZ |
denotes |
attenuates |
T2546 |
560-563 |
DT |
denotes |
the |
T2547 |
564-574 |
NN |
denotes |
expression |
T2548 |
575-577 |
IN |
denotes |
of |
T2549 |
578-581 |
DT |
denotes |
the |
T2551 |
582-586 |
NN |
denotes |
GluR |
T2553 |
586-587 |
HYPH |
denotes |
- |
T2552 |
587-591 |
NN |
denotes |
Bneo |
T2550 |
592-598 |
NN |
denotes |
allele |
T2554 |
599-600 |
-LRB- |
denotes |
[ |
T2555 |
600-602 |
CD |
denotes |
60 |
T2556 |
602-603 |
-RRB- |
denotes |
] |
T2557 |
603-604 |
. |
denotes |
. |
T2558 |
604-815 |
sentence |
denotes |
To unsilence the attenuated GluR-Bneo allele, specifically in the postnatal forebrain, we crossed in the TgCre4 transgene, which encodes Cre-recombinase and is driven by the αCaMKII promoter ([59]; “Camkcre4”). |
T2559 |
605-607 |
TO |
denotes |
To |
T2560 |
608-617 |
VB |
denotes |
unsilence |
T2562 |
618-621 |
DT |
denotes |
the |
T2564 |
622-632 |
VBN |
denotes |
attenuated |
T2565 |
633-637 |
NN |
denotes |
GluR |
T2567 |
637-638 |
HYPH |
denotes |
- |
T2566 |
638-642 |
NN |
denotes |
Bneo |
T2563 |
643-649 |
NN |
denotes |
allele |
T2568 |
649-651 |
, |
denotes |
, |
T2569 |
651-663 |
RB |
denotes |
specifically |
T2570 |
664-666 |
IN |
denotes |
in |
T2571 |
667-670 |
DT |
denotes |
the |
T2573 |
671-680 |
JJ |
denotes |
postnatal |
T2572 |
681-690 |
NN |
denotes |
forebrain |
T2574 |
690-692 |
, |
denotes |
, |
T2575 |
692-694 |
PRP |
denotes |
we |
T2561 |
695-702 |
VBD |
denotes |
crossed |
T2576 |
703-705 |
IN |
denotes |
in |
T2577 |
706-709 |
DT |
denotes |
the |
T2579 |
710-716 |
NN |
denotes |
TgCre4 |
T2578 |
717-726 |
NN |
denotes |
transgene |
T2580 |
726-728 |
, |
denotes |
, |
T2581 |
728-733 |
WDT |
denotes |
which |
T2582 |
734-741 |
VBZ |
denotes |
encodes |
T2583 |
742-745 |
NN |
denotes |
Cre |
T2585 |
745-746 |
HYPH |
denotes |
- |
T2584 |
746-757 |
NN |
denotes |
recombinase |
T2586 |
758-761 |
CC |
denotes |
and |
T2587 |
762-764 |
VBZ |
denotes |
is |
T2588 |
765-771 |
VBN |
denotes |
driven |
T2589 |
772-774 |
IN |
denotes |
by |
T2590 |
775-778 |
DT |
denotes |
the |
T2592 |
779-786 |
NN |
denotes |
αCaMKII |
T2591 |
787-795 |
NN |
denotes |
promoter |
T2593 |
796-797 |
-LRB- |
denotes |
( |
T2595 |
797-798 |
-LRB- |
denotes |
[ |
T2596 |
798-800 |
CD |
denotes |
59 |
T2597 |
800-801 |
-RRB- |
denotes |
] |
T2598 |
801-802 |
: |
denotes |
; |
T2599 |
803-804 |
`` |
denotes |
“ |
T2594 |
804-812 |
NN |
denotes |
Camkcre4 |
T2600 |
812-813 |
'' |
denotes |
” |
T2601 |
813-814 |
-RRB- |
denotes |
) |
T2602 |
814-815 |
. |
denotes |
. |
T2603 |
815-993 |
sentence |
denotes |
Thus, Cre-recombinase removes in forebrain neurons the intronic TK-neo gene, leading to the active GluR-BΔECS allele for Q/R site-unedited GluR-B(Q) subunits (Figures 1 and S1). |
T2604 |
816-820 |
RB |
denotes |
Thus |
T2606 |
820-822 |
, |
denotes |
, |
T2607 |
822-825 |
NN |
denotes |
Cre |
T2609 |
825-826 |
HYPH |
denotes |
- |
T2608 |
826-837 |
NN |
denotes |
recombinase |
T2605 |
838-845 |
VBZ |
denotes |
removes |
T2610 |
846-848 |
IN |
denotes |
in |
T2611 |
849-858 |
NN |
denotes |
forebrain |
T2612 |
859-866 |
NNS |
denotes |
neurons |
T2613 |
867-870 |
DT |
denotes |
the |
T2615 |
871-879 |
JJ |
denotes |
intronic |
T2616 |
880-882 |
NN |
denotes |
TK |
T2618 |
882-883 |
HYPH |
denotes |
- |
T2617 |
883-886 |
NN |
denotes |
neo |
T2614 |
887-891 |
NN |
denotes |
gene |
T2619 |
891-893 |
, |
denotes |
, |
T2620 |
893-900 |
VBG |
denotes |
leading |
T2621 |
901-903 |
IN |
denotes |
to |
T2622 |
904-907 |
DT |
denotes |
the |
T2624 |
908-914 |
JJ |
denotes |
active |
T2625 |
915-919 |
NN |
denotes |
GluR |
T2627 |
919-920 |
HYPH |
denotes |
- |
T2626 |
920-925 |
NN |
denotes |
BΔECS |
T2623 |
926-932 |
NN |
denotes |
allele |
T2628 |
933-936 |
IN |
denotes |
for |
T2629 |
937-938 |
NN |
denotes |
Q |
T2631 |
938-939 |
HYPH |
denotes |
/ |
T2630 |
939-940 |
NN |
denotes |
R |
T2632 |
941-945 |
NN |
denotes |
site |
T2634 |
945-946 |
HYPH |
denotes |
- |
T2633 |
946-954 |
JJ |
denotes |
unedited |
T2636 |
955-959 |
NN |
denotes |
GluR |
T2638 |
959-960 |
HYPH |
denotes |
- |
T2637 |
960-961 |
NN |
denotes |
B |
T2639 |
961-962 |
-LRB- |
denotes |
( |
T2640 |
962-963 |
NN |
denotes |
Q |
T2641 |
963-964 |
-RRB- |
denotes |
) |
T2635 |
965-973 |
NNS |
denotes |
subunits |
T2642 |
974-975 |
-LRB- |
denotes |
( |
T2644 |
975-982 |
NNS |
denotes |
Figures |
T2645 |
983-984 |
CD |
denotes |
1 |
T2646 |
985-988 |
CC |
denotes |
and |
T2643 |
989-991 |
NN |
denotes |
S1 |
T2647 |
991-992 |
-RRB- |
denotes |
) |
T2648 |
992-993 |
. |
denotes |
. |
T2649 |
993-1222 |
sentence |
denotes |
As expected [53,60], also in mice expressing postnatally forebrain-specific Q/R site-unedited GluR-B(Q) subunits, Ca2+ permeability through AMPAR was increased and AMPAR currents showed rectification ([58] and unpublished data). |
T2650 |
994-996 |
IN |
denotes |
As |
T2651 |
997-1005 |
VBN |
denotes |
expected |
T2653 |
1006-1007 |
-LRB- |
denotes |
[ |
T2655 |
1007-1009 |
CD |
denotes |
53 |
T2656 |
1009-1010 |
, |
denotes |
, |
T2654 |
1010-1012 |
CD |
denotes |
60 |
T2657 |
1012-1013 |
-RRB- |
denotes |
] |
T2658 |
1013-1015 |
, |
denotes |
, |
T2659 |
1015-1019 |
RB |
denotes |
also |
T2660 |
1020-1022 |
IN |
denotes |
in |
T2661 |
1023-1027 |
NNS |
denotes |
mice |
T2662 |
1028-1038 |
VBG |
denotes |
expressing |
T2663 |
1039-1050 |
RB |
denotes |
postnatally |
T2664 |
1051-1060 |
NN |
denotes |
forebrain |
T2666 |
1060-1061 |
HYPH |
denotes |
- |
T2665 |
1061-1069 |
JJ |
denotes |
specific |
T2668 |
1070-1071 |
NN |
denotes |
Q |
T2670 |
1071-1072 |
HYPH |
denotes |
/ |
T2669 |
1072-1073 |
NN |
denotes |
R |
T2671 |
1074-1078 |
NN |
denotes |
site |
T2673 |
1078-1079 |
HYPH |
denotes |
- |
T2672 |
1079-1087 |
JJ |
denotes |
unedited |
T2674 |
1088-1092 |
NN |
denotes |
GluR |
T2676 |
1092-1093 |
HYPH |
denotes |
- |
T2675 |
1093-1094 |
NN |
denotes |
B |
T2677 |
1094-1095 |
-LRB- |
denotes |
( |
T2678 |
1095-1096 |
NN |
denotes |
Q |
T2679 |
1096-1097 |
-RRB- |
denotes |
) |
T2667 |
1098-1106 |
NNS |
denotes |
subunits |
T2680 |
1106-1108 |
, |
denotes |
, |
T2681 |
1108-1111 |
NN |
denotes |
Ca2 |
T2683 |
1111-1112 |
SYM |
denotes |
+ |
T2682 |
1113-1125 |
NN |
denotes |
permeability |
T2684 |
1126-1133 |
IN |
denotes |
through |
T2685 |
1134-1139 |
NN |
denotes |
AMPAR |
T2686 |
1140-1143 |
VBD |
denotes |
was |
T2652 |
1144-1153 |
VBN |
denotes |
increased |
T2687 |
1154-1157 |
CC |
denotes |
and |
T2688 |
1158-1163 |
NN |
denotes |
AMPAR |
T2689 |
1164-1172 |
NNS |
denotes |
currents |
T2690 |
1173-1179 |
VBD |
denotes |
showed |
T2691 |
1180-1193 |
NN |
denotes |
rectification |
T2692 |
1194-1195 |
-LRB- |
denotes |
( |
T2694 |
1195-1196 |
-LRB- |
denotes |
[ |
T2693 |
1196-1198 |
CD |
denotes |
58 |
T2695 |
1198-1199 |
-RRB- |
denotes |
] |
T2696 |
1200-1203 |
CC |
denotes |
and |
T2697 |
1204-1215 |
JJ |
denotes |
unpublished |
T2698 |
1216-1220 |
NNS |
denotes |
data |
T2699 |
1220-1221 |
-RRB- |
denotes |
) |
T2700 |
1221-1222 |
. |
denotes |
. |
T2701 |
1222-1359 |
sentence |
denotes |
GluR-BΔECS:FB mice had, in contrast to mice expressing GluR-B(Q) globally, a prolonged lifespan and no severe developmental alterations. |
T2702 |
1223-1227 |
NN |
denotes |
GluR |
T2704 |
1227-1228 |
HYPH |
denotes |
- |
T2703 |
1228-1233 |
NN |
denotes |
BΔECS |
T2706 |
1233-1234 |
: |
denotes |
: |
T2707 |
1234-1236 |
NN |
denotes |
FB |
T2705 |
1237-1241 |
NNS |
denotes |
mice |
T2708 |
1242-1245 |
VBD |
denotes |
had |
T2709 |
1245-1247 |
, |
denotes |
, |
T2710 |
1247-1249 |
IN |
denotes |
in |
T2711 |
1250-1258 |
NN |
denotes |
contrast |
T2712 |
1259-1261 |
IN |
denotes |
to |
T2713 |
1262-1266 |
NNS |
denotes |
mice |
T2714 |
1267-1277 |
VBG |
denotes |
expressing |
T2715 |
1278-1282 |
NN |
denotes |
GluR |
T2717 |
1282-1283 |
HYPH |
denotes |
- |
T2718 |
1283-1284 |
NN |
denotes |
B |
T2719 |
1284-1285 |
-LRB- |
denotes |
( |
T2716 |
1285-1286 |
NN |
denotes |
Q |
T2720 |
1286-1287 |
-RRB- |
denotes |
) |
T2721 |
1288-1296 |
RB |
denotes |
globally |
T2722 |
1296-1298 |
, |
denotes |
, |
T2723 |
1298-1299 |
DT |
denotes |
a |
T2725 |
1300-1309 |
VBN |
denotes |
prolonged |
T2724 |
1310-1318 |
NN |
denotes |
lifespan |
T2726 |
1319-1322 |
CC |
denotes |
and |
T2727 |
1323-1325 |
DT |
denotes |
no |
T2729 |
1326-1332 |
JJ |
denotes |
severe |
T2730 |
1333-1346 |
JJ |
denotes |
developmental |
T2728 |
1347-1358 |
NNS |
denotes |
alterations |
T2731 |
1358-1359 |
. |
denotes |
. |
T2732 |
1359-1475 |
sentence |
denotes |
They were however, still seizure-prone [58], and hence behavioral training was restricted to short periods of time. |
T2733 |
1360-1364 |
PRP |
denotes |
They |
T2734 |
1365-1369 |
VBD |
denotes |
were |
T2735 |
1370-1377 |
RB |
denotes |
however |
T2736 |
1377-1379 |
, |
denotes |
, |
T2737 |
1379-1384 |
RB |
denotes |
still |
T2738 |
1385-1392 |
NN |
denotes |
seizure |
T2740 |
1392-1393 |
HYPH |
denotes |
- |
T2739 |
1393-1398 |
JJ |
denotes |
prone |
T2741 |
1399-1400 |
-LRB- |
denotes |
[ |
T2742 |
1400-1402 |
CD |
denotes |
58 |
T2743 |
1402-1403 |
-RRB- |
denotes |
] |
T2744 |
1403-1405 |
, |
denotes |
, |
T2745 |
1405-1408 |
CC |
denotes |
and |
T2746 |
1409-1414 |
RB |
denotes |
hence |
T2748 |
1415-1425 |
JJ |
denotes |
behavioral |
T2749 |
1426-1434 |
NN |
denotes |
training |
T2750 |
1435-1438 |
VBD |
denotes |
was |
T2747 |
1439-1449 |
VBN |
denotes |
restricted |
T2751 |
1450-1452 |
IN |
denotes |
to |
T2752 |
1453-1458 |
JJ |
denotes |
short |
T2753 |
1459-1466 |
NNS |
denotes |
periods |
T2754 |
1467-1469 |
IN |
denotes |
of |
T2755 |
1470-1474 |
NN |
denotes |
time |
T2756 |
1474-1475 |
. |
denotes |
. |
R1442 |
T2419 |
T2420 |
aux |
To,explore |
R1443 |
T2420 |
T2421 |
advcl |
explore,analyzed |
R1444 |
T2422 |
T2423 |
det |
the,role |
R1445 |
T2423 |
T2420 |
dobj |
role,explore |
R1446 |
T2424 |
T2423 |
prep |
of,role |
R1447 |
T2425 |
T2426 |
amod |
fast,neurotransmission |
R1448 |
T2426 |
T2424 |
pobj |
neurotransmission,of |
R1449 |
T2427 |
T2426 |
amod |
excitatory,neurotransmission |
R1450 |
T2428 |
T2426 |
acl |
carried,neurotransmission |
R1451 |
T2429 |
T2428 |
prep |
by,carried |
R1452 |
T2430 |
T2431 |
compound |
GluR,B |
R1453 |
T2431 |
T2433 |
npadvmod |
B,containing |
R1454 |
T2432 |
T2431 |
punct |
-,B |
R1455 |
T2433 |
T2435 |
amod |
containing,channels |
R1456 |
T2434 |
T2433 |
punct |
-,containing |
R1457 |
T2435 |
T2429 |
pobj |
channels,by |
R1458 |
T2436 |
T2435 |
compound |
AMPA,channels |
R1459 |
T2437 |
T2423 |
prep |
in,role |
R1460 |
T2438 |
T2439 |
amod |
olfactory,processes |
R1461 |
T2439 |
T2437 |
pobj |
processes,in |
R1462 |
T2440 |
T2421 |
punct |
", ",analyzed |
R1463 |
T2441 |
T2421 |
nsubj |
we,analyzed |
R1464 |
T2442 |
T2421 |
advmod |
first,analyzed |
R1465 |
T2443 |
T2421 |
dobj |
mice,analyzed |
R1466 |
T2444 |
T2445 |
dep |
that,express |
R1467 |
T2445 |
T2443 |
relcl |
express,mice |
R1468 |
T2446 |
T2445 |
dobj |
part,express |
R1469 |
T2447 |
T2446 |
prep |
of,part |
R1470 |
T2448 |
T2449 |
det |
the,population |
R1471 |
T2449 |
T2447 |
pobj |
population,of |
R1472 |
T2450 |
T2451 |
compound |
GluR,B |
R1473 |
T2451 |
T2449 |
compound |
B,population |
R1474 |
T2452 |
T2451 |
punct |
-,B |
R1475 |
T2453 |
T2445 |
prep |
in,express |
R1476 |
T2454 |
T2455 |
det |
a,form |
R1477 |
T2455 |
T2453 |
pobj |
form,in |
R1478 |
T2456 |
T2457 |
compound |
Q,R |
R1479 |
T2457 |
T2459 |
compound |
R,site |
R1480 |
T2458 |
T2457 |
punct |
/,R |
R1481 |
T2459 |
T2460 |
npadvmod |
site,unedited |
R1482 |
T2460 |
T2455 |
amod |
unedited,form |
R1483 |
T2461 |
T2460 |
punct |
-,unedited |
R1484 |
T2462 |
T2463 |
punct |
(,1A |
R1485 |
T2463 |
T2421 |
parataxis |
1A,analyzed |
R1486 |
T2464 |
T2463 |
compound |
Figure,1A |
R1487 |
T2465 |
T2463 |
punct |
;,1A |
R1488 |
T2466 |
T2463 |
advcl |
termed,1A |
R1489 |
T2467 |
T2466 |
punct |
“,termed |
R1490 |
T2468 |
T2469 |
compound |
GluR,BΔECS |
R1491 |
T2469 |
T2466 |
oprd |
BΔECS,termed |
R1492 |
T2470 |
T2469 |
punct |
-,BΔECS |
R1493 |
T2471 |
T2469 |
punct |
:,BΔECS |
R1494 |
T2472 |
T2469 |
appos |
FB,BΔECS |
R1495 |
T2473 |
T2463 |
punct |
”,1A |
R1496 |
T2474 |
T2463 |
punct |
;,1A |
R1497 |
T2475 |
T2463 |
advcl |
see,1A |
R1498 |
T2476 |
T2475 |
advmod |
also,see |
R1499 |
T2477 |
T2475 |
punct |
[,see |
R1500 |
T2478 |
T2475 |
dobj |
58,see |
R1501 |
T2479 |
T2463 |
punct |
],1A |
R1502 |
T2480 |
T2463 |
punct |
),1A |
R1503 |
T2481 |
T2421 |
punct |
.,analyzed |
R1504 |
T2483 |
T2484 |
det |
These,mice |
R1505 |
T2484 |
T2485 |
nsubj |
mice,carry |
R1506 |
T2486 |
T2485 |
punct |
", ",carry |
R1507 |
T2487 |
T2485 |
prep |
in,carry |
R1508 |
T2488 |
T2487 |
pobj |
addition,in |
R1509 |
T2489 |
T2488 |
prep |
to,addition |
R1510 |
T2490 |
T2491 |
det |
a,allele |
R1511 |
T2491 |
T2489 |
pobj |
allele,to |
R1512 |
T2492 |
T2493 |
amod |
wild,type |
R1513 |
T2493 |
T2491 |
compound |
type,allele |
R1514 |
T2494 |
T2493 |
punct |
-,type |
R1515 |
T2495 |
T2496 |
compound |
GluR,B |
R1516 |
T2496 |
T2491 |
compound |
B,allele |
R1517 |
T2497 |
T2496 |
punct |
-,B |
R1518 |
T2498 |
T2485 |
punct |
", ",carry |
R1519 |
T2499 |
T2500 |
det |
a,allele |
R1520 |
T2500 |
T2485 |
dobj |
allele,carry |
R1521 |
T2501 |
T2502 |
npadvmod |
gene,targeted |
R1522 |
T2502 |
T2500 |
amod |
targeted,allele |
R1523 |
T2503 |
T2502 |
punct |
-,targeted |
R1524 |
T2504 |
T2505 |
compound |
GluR,Bneo |
R1525 |
T2505 |
T2500 |
compound |
Bneo,allele |
R1526 |
T2506 |
T2505 |
punct |
-,Bneo |
R1527 |
T2507 |
T2508 |
prep |
in,replaced |
R1528 |
T2508 |
T2500 |
relcl |
replaced,allele |
R1529 |
T2509 |
T2507 |
pobj |
which,in |
R1530 |
T2510 |
T2511 |
det |
the,sequence |
R1531 |
T2511 |
T2508 |
nsubjpass |
sequence,replaced |
R1532 |
T2512 |
T2511 |
amod |
intronic,sequence |
R1533 |
T2513 |
T2511 |
amod |
critical,sequence |
R1534 |
T2514 |
T2513 |
prep |
for,critical |
R1535 |
T2515 |
T2516 |
compound |
GluR,B |
R1536 |
T2516 |
T2518 |
compound |
B,editing |
R1537 |
T2517 |
T2516 |
punct |
-,B |
R1538 |
T2518 |
T2514 |
pobj |
editing,for |
R1539 |
T2519 |
T2518 |
compound |
pre-mRNA,editing |
R1540 |
T2520 |
T2518 |
prep |
at,editing |
R1541 |
T2521 |
T2522 |
det |
the,site |
R1542 |
T2522 |
T2520 |
pobj |
site,at |
R1543 |
T2523 |
T2524 |
compound |
Q,R |
R1544 |
T2524 |
T2522 |
compound |
R,site |
R1545 |
T2525 |
T2524 |
punct |
/,R |
R1546 |
T2526 |
T2508 |
auxpass |
is,replaced |
R1547 |
T2527 |
T2508 |
agent |
by,replaced |
R1548 |
T2528 |
T2529 |
det |
a,gene |
R1549 |
T2529 |
T2527 |
pobj |
gene,by |
R1550 |
T2530 |
T2529 |
amod |
floxed,gene |
R1551 |
T2531 |
T2532 |
compound |
TK,neo |
R1552 |
T2532 |
T2529 |
compound |
neo,gene |
R1553 |
T2533 |
T2532 |
punct |
-,neo |
R1554 |
T2534 |
T2529 |
punct |
", ",gene |
R1555 |
T2535 |
T2536 |
dep |
which,reduces |
R1556 |
T2536 |
T2529 |
relcl |
reduces,gene |
R1557 |
T2537 |
T2536 |
advmod |
severely,reduces |
R1558 |
T2538 |
T2536 |
dobj |
splicing,reduces |
R1559 |
T2539 |
T2538 |
prep |
of,splicing |
R1560 |
T2540 |
T2541 |
det |
the,intron |
R1561 |
T2541 |
T2539 |
pobj |
intron,of |
R1562 |
T2542 |
T2541 |
amod |
modified,intron |
R1563 |
T2543 |
T2536 |
cc |
and,reduces |
R1564 |
T2544 |
T2545 |
advmod |
hence,attenuates |
R1565 |
T2545 |
T2536 |
conj |
attenuates,reduces |
R1566 |
T2546 |
T2547 |
det |
the,expression |
R1567 |
T2547 |
T2545 |
dobj |
expression,attenuates |
R1568 |
T2548 |
T2547 |
prep |
of,expression |
R1569 |
T2549 |
T2550 |
det |
the,allele |
R1570 |
T2550 |
T2548 |
pobj |
allele,of |
R1571 |
T2551 |
T2552 |
compound |
GluR,Bneo |
R1572 |
T2552 |
T2550 |
compound |
Bneo,allele |
R1573 |
T2553 |
T2552 |
punct |
-,Bneo |
R1574 |
T2554 |
T2555 |
punct |
[,60 |
R1575 |
T2555 |
T2485 |
parataxis |
60,carry |
R1576 |
T2556 |
T2555 |
punct |
],60 |
R1577 |
T2557 |
T2485 |
punct |
.,carry |
R1578 |
T2559 |
T2560 |
aux |
To,unsilence |
R1579 |
T2560 |
T2561 |
advcl |
unsilence,crossed |
R1580 |
T2562 |
T2563 |
det |
the,allele |
R1581 |
T2563 |
T2560 |
dobj |
allele,unsilence |
R1582 |
T2564 |
T2563 |
amod |
attenuated,allele |
R1583 |
T2565 |
T2566 |
compound |
GluR,Bneo |
R1584 |
T2566 |
T2563 |
compound |
Bneo,allele |
R1585 |
T2567 |
T2566 |
punct |
-,Bneo |
R1586 |
T2568 |
T2560 |
punct |
", ",unsilence |
R1587 |
T2569 |
T2570 |
advmod |
specifically,in |
R1588 |
T2570 |
T2560 |
prep |
in,unsilence |
R1589 |
T2571 |
T2572 |
det |
the,forebrain |
R1590 |
T2572 |
T2570 |
pobj |
forebrain,in |
R1591 |
T2573 |
T2572 |
amod |
postnatal,forebrain |
R1592 |
T2574 |
T2561 |
punct |
", ",crossed |
R1593 |
T2575 |
T2561 |
nsubj |
we,crossed |
R1594 |
T2576 |
T2561 |
prep |
in,crossed |
R1595 |
T2577 |
T2578 |
det |
the,transgene |
R1596 |
T2578 |
T2576 |
pobj |
transgene,in |
R1597 |
T2579 |
T2578 |
compound |
TgCre4,transgene |
R1598 |
T2580 |
T2578 |
punct |
", ",transgene |
R1599 |
T2581 |
T2582 |
dep |
which,encodes |
R1600 |
T2582 |
T2578 |
relcl |
encodes,transgene |
R1601 |
T2583 |
T2584 |
compound |
Cre,recombinase |
R1602 |
T2584 |
T2582 |
dobj |
recombinase,encodes |
R1603 |
T2585 |
T2584 |
punct |
-,recombinase |
R1604 |
T2586 |
T2582 |
cc |
and,encodes |
R1605 |
T2587 |
T2588 |
auxpass |
is,driven |
R1606 |
T2588 |
T2582 |
conj |
driven,encodes |
R1607 |
T2589 |
T2588 |
agent |
by,driven |
R1608 |
T2590 |
T2591 |
det |
the,promoter |
R1609 |
T2591 |
T2589 |
pobj |
promoter,by |
R1610 |
T2592 |
T2591 |
compound |
αCaMKII,promoter |
R1611 |
T2593 |
T2594 |
punct |
(,Camkcre4 |
R1612 |
T2594 |
T2561 |
parataxis |
Camkcre4,crossed |
R1613 |
T2595 |
T2594 |
punct |
[,Camkcre4 |
R1614 |
T2596 |
T2594 |
dep |
59,Camkcre4 |
R1615 |
T2597 |
T2594 |
punct |
],Camkcre4 |
R1616 |
T2598 |
T2594 |
punct |
;,Camkcre4 |
R1617 |
T2599 |
T2594 |
punct |
“,Camkcre4 |
R1618 |
T2600 |
T2594 |
punct |
”,Camkcre4 |
R1619 |
T2601 |
T2594 |
punct |
),Camkcre4 |
R1620 |
T2602 |
T2561 |
punct |
.,crossed |
R1621 |
T2604 |
T2605 |
advmod |
Thus,removes |
R1622 |
T2606 |
T2605 |
punct |
", ",removes |
R1623 |
T2607 |
T2608 |
compound |
Cre,recombinase |
R1624 |
T2608 |
T2605 |
nsubj |
recombinase,removes |
R1625 |
T2609 |
T2608 |
punct |
-,recombinase |
R1626 |
T2610 |
T2605 |
prep |
in,removes |
R1627 |
T2611 |
T2612 |
compound |
forebrain,neurons |
R1628 |
T2612 |
T2610 |
pobj |
neurons,in |
R1629 |
T2613 |
T2614 |
det |
the,gene |
R1630 |
T2614 |
T2605 |
dobj |
gene,removes |
R1631 |
T2615 |
T2614 |
amod |
intronic,gene |
R1632 |
T2616 |
T2617 |
compound |
TK,neo |
R1633 |
T2617 |
T2614 |
compound |
neo,gene |
R1634 |
T2618 |
T2617 |
punct |
-,neo |
R1635 |
T2619 |
T2605 |
punct |
", ",removes |
R1636 |
T2620 |
T2605 |
advcl |
leading,removes |
R1637 |
T2621 |
T2620 |
prep |
to,leading |
R1638 |
T2622 |
T2623 |
det |
the,allele |
R1639 |
T2623 |
T2621 |
pobj |
allele,to |
R1640 |
T2624 |
T2623 |
amod |
active,allele |
R1641 |
T2625 |
T2626 |
compound |
GluR,BΔECS |
R1642 |
T2626 |
T2623 |
compound |
BΔECS,allele |
R1643 |
T2627 |
T2626 |
punct |
-,BΔECS |
R1644 |
T2628 |
T2623 |
prep |
for,allele |
R1645 |
T2629 |
T2630 |
compound |
Q,R |
R1646 |
T2630 |
T2632 |
compound |
R,site |
R1647 |
T2631 |
T2630 |
punct |
/,R |
R1648 |
T2632 |
T2633 |
npadvmod |
site,unedited |
R1649 |
T2633 |
T2635 |
amod |
unedited,subunits |
R1650 |
T2634 |
T2633 |
punct |
-,unedited |
R1651 |
T2635 |
T2628 |
pobj |
subunits,for |
R1652 |
T2636 |
T2637 |
nmod |
GluR,B |
R1653 |
T2637 |
T2635 |
nmod |
B,subunits |
R1654 |
T2638 |
T2637 |
punct |
-,B |
R1655 |
T2639 |
T2640 |
punct |
(,Q |
R1656 |
T2640 |
T2635 |
parataxis |
Q,subunits |
R1657 |
T2641 |
T2640 |
punct |
),Q |
R1658 |
T2642 |
T2643 |
punct |
(,S1 |
R1659 |
T2643 |
T2605 |
parataxis |
S1,removes |
R1660 |
T2644 |
T2643 |
dep |
Figures,S1 |
R1661 |
T2645 |
T2643 |
nummod |
1,S1 |
R1662 |
T2646 |
T2643 |
cc |
and,S1 |
R1663 |
T2647 |
T2643 |
punct |
),S1 |
R1664 |
T2648 |
T2605 |
punct |
.,removes |
R1665 |
T2650 |
T2651 |
mark |
As,expected |
R1666 |
T2651 |
T2652 |
advcl |
expected,increased |
R1667 |
T2653 |
T2654 |
punct |
[,60 |
R1668 |
T2654 |
T2651 |
parataxis |
60,expected |
R1669 |
T2655 |
T2654 |
nummod |
53,60 |
R1670 |
T2656 |
T2654 |
punct |
",",60 |
R1671 |
T2657 |
T2654 |
punct |
],60 |
R1672 |
T2658 |
T2652 |
punct |
", ",increased |
R1673 |
T2659 |
T2660 |
advmod |
also,in |
R1674 |
T2660 |
T2652 |
prep |
in,increased |
R1675 |
T2661 |
T2660 |
pobj |
mice,in |
R1676 |
T2662 |
T2661 |
acl |
expressing,mice |
R1677 |
T2663 |
T2662 |
advmod |
postnatally,expressing |
R1678 |
T2664 |
T2665 |
npadvmod |
forebrain,specific |
R1679 |
T2665 |
T2667 |
amod |
specific,subunits |
R1680 |
T2666 |
T2665 |
punct |
-,specific |
R1681 |
T2667 |
T2662 |
dobj |
subunits,expressing |
R1682 |
T2668 |
T2669 |
compound |
Q,R |
R1683 |
T2669 |
T2671 |
compound |
R,site |
R1684 |
T2670 |
T2669 |
punct |
/,R |
R1685 |
T2671 |
T2672 |
npadvmod |
site,unedited |
R1686 |
T2672 |
T2667 |
amod |
unedited,subunits |
R1687 |
T2673 |
T2672 |
punct |
-,unedited |
R1688 |
T2674 |
T2675 |
nmod |
GluR,B |
R1689 |
T2675 |
T2667 |
nmod |
B,subunits |
R1690 |
T2676 |
T2675 |
punct |
-,B |
R1691 |
T2677 |
T2678 |
punct |
(,Q |
R1692 |
T2678 |
T2667 |
parataxis |
Q,subunits |
R1693 |
T2679 |
T2678 |
punct |
),Q |
R1694 |
T2680 |
T2652 |
punct |
", ",increased |
R1695 |
T2681 |
T2682 |
nmod |
Ca2,permeability |
R1696 |
T2682 |
T2652 |
nsubjpass |
permeability,increased |
R1697 |
T2683 |
T2681 |
punct |
+,Ca2 |
R1698 |
T2684 |
T2682 |
prep |
through,permeability |
R1699 |
T2685 |
T2684 |
pobj |
AMPAR,through |
R1700 |
T2686 |
T2652 |
auxpass |
was,increased |
R1701 |
T2687 |
T2652 |
cc |
and,increased |
R1702 |
T2688 |
T2689 |
compound |
AMPAR,currents |
R1703 |
T2689 |
T2690 |
nsubj |
currents,showed |
R1704 |
T2690 |
T2652 |
conj |
showed,increased |
R1705 |
T2691 |
T2690 |
dobj |
rectification,showed |
R1706 |
T2692 |
T2693 |
punct |
(,58 |
R1707 |
T2693 |
T2690 |
parataxis |
58,showed |
R1708 |
T2694 |
T2693 |
punct |
[,58 |
R1709 |
T2695 |
T2693 |
punct |
],58 |
R1710 |
T2696 |
T2693 |
cc |
and,58 |
R1711 |
T2697 |
T2698 |
amod |
unpublished,data |
R1712 |
T2698 |
T2693 |
conj |
data,58 |
R1713 |
T2699 |
T2698 |
punct |
),data |
R1714 |
T2700 |
T2652 |
punct |
.,increased |
R1715 |
T2702 |
T2703 |
nmod |
GluR,BΔECS |
R1716 |
T2703 |
T2705 |
nmod |
BΔECS,mice |
R1717 |
T2704 |
T2703 |
punct |
-,BΔECS |
R1718 |
T2705 |
T2708 |
nsubj |
mice,had |
R1719 |
T2706 |
T2703 |
punct |
:,BΔECS |
R1720 |
T2707 |
T2703 |
appos |
FB,BΔECS |
R1721 |
T2709 |
T2708 |
punct |
", ",had |
R1722 |
T2710 |
T2708 |
prep |
in,had |
R1723 |
T2711 |
T2710 |
pobj |
contrast,in |
R1724 |
T2712 |
T2711 |
prep |
to,contrast |
R1725 |
T2713 |
T2712 |
pobj |
mice,to |
R1726 |
T2714 |
T2713 |
acl |
expressing,mice |
R1727 |
T2715 |
T2716 |
nmod |
GluR,Q |
R1728 |
T2716 |
T2714 |
dobj |
Q,expressing |
R1729 |
T2717 |
T2716 |
punct |
-,Q |
R1730 |
T2718 |
T2716 |
nmod |
B,Q |
R1731 |
T2719 |
T2716 |
punct |
(,Q |
R1732 |
T2720 |
T2716 |
punct |
),Q |
R1733 |
T2721 |
T2714 |
advmod |
globally,expressing |
R1734 |
T2722 |
T2708 |
punct |
", ",had |
R1735 |
T2723 |
T2724 |
det |
a,lifespan |
R1736 |
T2724 |
T2708 |
dobj |
lifespan,had |
R1737 |
T2725 |
T2724 |
amod |
prolonged,lifespan |
R1738 |
T2726 |
T2724 |
cc |
and,lifespan |
R1739 |
T2727 |
T2728 |
det |
no,alterations |
R1740 |
T2728 |
T2724 |
conj |
alterations,lifespan |
R1741 |
T2729 |
T2728 |
amod |
severe,alterations |
R1742 |
T2730 |
T2728 |
amod |
developmental,alterations |
R1743 |
T2731 |
T2708 |
punct |
.,had |
R1744 |
T2733 |
T2734 |
nsubj |
They,were |
R1745 |
T2735 |
T2734 |
advmod |
however,were |
R1746 |
T2736 |
T2734 |
punct |
", ",were |
R1747 |
T2737 |
T2734 |
advmod |
still,were |
R1748 |
T2738 |
T2739 |
npadvmod |
seizure,prone |
R1749 |
T2739 |
T2734 |
acomp |
prone,were |
R1750 |
T2740 |
T2739 |
punct |
-,prone |
R1751 |
T2741 |
T2742 |
punct |
[,58 |
R1752 |
T2742 |
T2734 |
parataxis |
58,were |
R1753 |
T2743 |
T2742 |
punct |
],58 |
R1754 |
T2744 |
T2734 |
punct |
", ",were |
R1755 |
T2745 |
T2734 |
cc |
and,were |
R1756 |
T2746 |
T2747 |
advmod |
hence,restricted |
R1757 |
T2747 |
T2734 |
conj |
restricted,were |
R1758 |
T2748 |
T2749 |
amod |
behavioral,training |
R1759 |
T2749 |
T2747 |
nsubjpass |
training,restricted |
R1760 |
T2750 |
T2747 |
auxpass |
was,restricted |
R1761 |
T2751 |
T2747 |
prep |
to,restricted |
R1762 |
T2752 |
T2753 |
amod |
short,periods |
R1763 |
T2753 |
T2751 |
pobj |
periods,to |
R1764 |
T2754 |
T2753 |
prep |
of,periods |
R1765 |
T2755 |
T2754 |
pobj |
time,of |
R1766 |
T2756 |
T2747 |
punct |
.,restricted |