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PMC:1255741 / 1608-7845 JSONTXT 5 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T655 13-16 DT denotes The
T656 17-22 NN denotes sense
T658 23-25 IN denotes of
T659 26-31 NN denotes smell
T657 32-34 VBZ denotes is
T660 35-37 IN denotes of
T661 38-47 JJ denotes paramount
T662 48-58 NN denotes importance
T663 59-62 IN denotes for
T664 63-70 NNS denotes rodents
T665 71-72 -LRB- denotes [
T666 72-73 CD denotes 1
T667 73-74 -RRB- denotes ]
T668 74-76 , denotes ,
T669 76-79 IN denotes for
T671 80-85 WDT denotes which
T672 86-91 JJ denotes rapid
T674 92-96 NN denotes odor
T673 97-111 NN denotes discrimination
T675 112-115 CC denotes and
T676 116-120 RB denotes long
T678 120-121 HYPH denotes -
T677 121-128 VBG denotes lasting
T680 129-138 JJ denotes olfactory
T679 139-145 NN denotes memory
T670 146-153 VBZ denotes permits
T681 154-163 NNS denotes responses
T682 164-166 IN denotes to
T683 167-175 NN denotes predator
T684 176-179 CC denotes and
T685 180-184 NN denotes prey
T686 185-193 JJ denotes critical
T687 194-197 IN denotes for
T688 198-206 NN denotes survival
T689 206-207 . denotes .
T690 207-335 sentence denotes Consequently, the behavioral analyses of olfactory capabilities in rodents are efficient, quantitative, and reproducible [2–4].
T691 208-220 RB denotes Consequently
T693 220-222 , denotes ,
T694 222-225 DT denotes the
T696 226-236 JJ denotes behavioral
T695 237-245 NNS denotes analyses
T697 246-248 IN denotes of
T698 249-258 JJ denotes olfactory
T699 259-271 NNS denotes capabilities
T700 272-274 IN denotes in
T701 275-282 NNS denotes rodents
T692 283-286 VBP denotes are
T702 287-296 JJ denotes efficient
T703 296-298 , denotes ,
T704 298-310 JJ denotes quantitative
T705 310-312 , denotes ,
T706 312-315 CC denotes and
T707 316-328 JJ denotes reproducible
T708 329-330 -LRB- denotes [
T709 330-331 CD denotes 2
T710 331-332 SYM denotes –
T711 332-333 CD denotes 4
T712 333-334 -RRB- denotes ]
T713 334-335 . denotes .
T714 335-557 sentence denotes While in the formation and storage of olfactory memory piriform cortex [5–7], hippocampus [8,9], and olfactory bulb [10–12] are all implicated, the cellular correlates for these processes have not been clearly delineated.
T715 336-341 IN denotes While
T717 342-344 IN denotes in
T718 345-348 DT denotes the
T719 349-358 NN denotes formation
T720 359-362 CC denotes and
T721 363-370 NN denotes storage
T722 371-373 IN denotes of
T723 374-383 JJ denotes olfactory
T724 384-390 NN denotes memory
T725 391-399 JJ denotes piriform
T726 400-406 NN denotes cortex
T727 407-408 -LRB- denotes [
T728 408-409 CD denotes 5
T729 409-410 SYM denotes –
T730 410-411 CD denotes 7
T731 411-412 -RRB- denotes ]
T732 412-414 , denotes ,
T733 414-425 NN denotes hippocampus
T734 426-427 -LRB- denotes [
T736 427-428 CD denotes 8
T737 428-429 , denotes ,
T735 429-430 CD denotes 9
T738 430-431 -RRB- denotes ]
T739 431-433 , denotes ,
T740 433-436 CC denotes and
T741 437-446 JJ denotes olfactory
T742 447-451 NN denotes bulb
T743 452-453 -LRB- denotes [
T744 453-455 CD denotes 10
T745 455-456 SYM denotes –
T746 456-458 CD denotes 12
T747 458-459 -RRB- denotes ]
T748 460-463 VBP denotes are
T749 464-467 RB denotes all
T716 468-478 VBN denotes implicated
T751 478-480 , denotes ,
T752 480-483 DT denotes the
T754 484-492 JJ denotes cellular
T753 493-503 NNS denotes correlates
T755 504-507 IN denotes for
T756 508-513 DT denotes these
T757 514-523 NNS denotes processes
T758 524-528 VBP denotes have
T759 529-532 RB denotes not
T760 533-537 VBN denotes been
T761 538-545 RB denotes clearly
T750 546-556 VBN denotes delineated
T762 556-557 . denotes .
T763 557-724 sentence denotes The contribution of the hippocampus to olfactory memory is presently controversial [2,13–18], but is deemed unlikely for simple olfactory discrimination tasks [9,19].
T764 558-561 DT denotes The
T765 562-574 NN denotes contribution
T767 575-577 IN denotes of
T768 578-581 DT denotes the
T769 582-593 NN denotes hippocampus
T770 594-596 IN denotes to
T771 597-606 JJ denotes olfactory
T772 607-613 NN denotes memory
T766 614-616 VBZ denotes is
T773 617-626 RB denotes presently
T774 627-640 JJ denotes controversial
T775 641-642 -LRB- denotes [
T776 642-643 CD denotes 2
T777 643-644 , denotes ,
T778 644-646 CD denotes 13
T779 646-647 SYM denotes –
T780 647-649 CD denotes 18
T781 649-650 -RRB- denotes ]
T782 650-652 , denotes ,
T783 652-655 CC denotes but
T784 656-658 VBZ denotes is
T785 659-665 VBN denotes deemed
T786 666-674 JJ denotes unlikely
T787 675-678 IN denotes for
T788 679-685 JJ denotes simple
T790 686-695 JJ denotes olfactory
T791 696-710 NN denotes discrimination
T789 711-716 NNS denotes tasks
T792 717-718 -LRB- denotes [
T794 718-719 CD denotes 9
T795 719-720 , denotes ,
T793 720-722 CD denotes 19
T796 722-723 -RRB- denotes ]
T797 723-724 . denotes .
T798 724-991 sentence denotes In fact, the most likely candidates for a cellular correlate of olfactory memory appear to be the neuronal connections in the piriform cortex due to the associational connectivity [5] and the expression of several forms of cellular and synaptic plasticity [7,20–23].
T799 725-727 IN denotes In
T801 728-732 NN denotes fact
T802 732-734 , denotes ,
T803 734-737 DT denotes the
T805 738-742 RBS denotes most
T806 743-749 JJ denotes likely
T804 750-760 NNS denotes candidates
T807 761-764 IN denotes for
T808 765-766 DT denotes a
T810 767-775 JJ denotes cellular
T809 776-785 NN denotes correlate
T811 786-788 IN denotes of
T812 789-798 JJ denotes olfactory
T813 799-805 NN denotes memory
T800 806-812 VBP denotes appear
T814 813-815 TO denotes to
T815 816-818 VB denotes be
T816 819-822 DT denotes the
T818 823-831 JJ denotes neuronal
T817 832-843 NNS denotes connections
T819 844-846 IN denotes in
T820 847-850 DT denotes the
T822 851-859 JJ denotes piriform
T821 860-866 NN denotes cortex
T823 867-870 IN denotes due
T824 871-873 IN denotes to
T825 874-877 DT denotes the
T827 878-891 JJ denotes associational
T826 892-904 NN denotes connectivity
T828 905-906 -LRB- denotes [
T829 906-907 CD denotes 5
T830 907-908 -RRB- denotes ]
T831 909-912 CC denotes and
T832 913-916 DT denotes the
T833 917-927 NN denotes expression
T834 928-930 IN denotes of
T835 931-938 JJ denotes several
T836 939-944 NNS denotes forms
T837 945-947 IN denotes of
T838 948-956 JJ denotes cellular
T840 957-960 CC denotes and
T841 961-969 JJ denotes synaptic
T839 970-980 NN denotes plasticity
T842 981-982 -LRB- denotes [
T843 982-983 CD denotes 7
T844 983-984 , denotes ,
T845 984-986 CD denotes 20
T846 986-987 SYM denotes –
T847 987-989 CD denotes 23
T848 989-990 -RRB- denotes ]
T849 990-991 . denotes .
T850 991-1170 sentence denotes Concerning odor discrimination itself, cellular mechanisms for this process are often attributed to the inhibitory circuitry of the olfactory bulb ([24–30]; reviewed in [31–33]).
T851 992-1002 VBG denotes Concerning
T853 1003-1007 NN denotes odor
T854 1008-1022 NN denotes discrimination
T855 1023-1029 PRP denotes itself
T856 1029-1031 , denotes ,
T857 1031-1039 JJ denotes cellular
T858 1040-1050 NNS denotes mechanisms
T859 1051-1054 IN denotes for
T860 1055-1059 DT denotes this
T861 1060-1067 NN denotes process
T862 1068-1071 VBP denotes are
T863 1072-1077 RB denotes often
T852 1078-1088 VBN denotes attributed
T864 1089-1091 IN denotes to
T865 1092-1095 DT denotes the
T867 1096-1106 JJ denotes inhibitory
T866 1107-1116 NN denotes circuitry
T868 1117-1119 IN denotes of
T869 1120-1123 DT denotes the
T871 1124-1133 JJ denotes olfactory
T870 1134-1138 NN denotes bulb
T872 1139-1140 -LRB- denotes (
T874 1140-1141 -LRB- denotes [
T875 1141-1143 CD denotes 24
T876 1143-1144 SYM denotes –
T877 1144-1146 CD denotes 30
T878 1146-1147 -RRB- denotes ]
T879 1147-1148 : denotes ;
T873 1149-1157 VBN denotes reviewed
T880 1158-1160 IN denotes in
T881 1161-1162 -LRB- denotes [
T882 1162-1164 CD denotes 31
T883 1164-1165 SYM denotes –
T884 1165-1167 CD denotes 33
T885 1167-1168 -RRB- denotes ]
T886 1168-1169 -RRB- denotes )
T887 1169-1170 . denotes .
T888 1170-1414 sentence denotes Lateral inhibitory circuits were postulated, in analogy to retina [34,35], to mediate contrast enhancement [24], for which physiological recordings [24,36,37] and modeling data, based on the well-known anatomy [29], provide additional support.
T889 1171-1178 JJ denotes Lateral
T891 1179-1189 JJ denotes inhibitory
T890 1190-1198 NNS denotes circuits
T893 1199-1203 VBD denotes were
T892 1204-1214 VBN denotes postulated
T894 1214-1216 , denotes ,
T895 1216-1218 IN denotes in
T896 1219-1226 NN denotes analogy
T897 1227-1229 IN denotes to
T898 1230-1236 NN denotes retina
T899 1237-1238 -LRB- denotes [
T901 1238-1240 CD denotes 34
T902 1240-1241 , denotes ,
T900 1241-1243 CD denotes 35
T903 1243-1244 -RRB- denotes ]
T904 1244-1246 , denotes ,
T905 1246-1248 TO denotes to
T906 1249-1256 VB denotes mediate
T907 1257-1265 NN denotes contrast
T908 1266-1277 NN denotes enhancement
T909 1278-1279 -LRB- denotes [
T910 1279-1281 CD denotes 24
T911 1281-1282 -RRB- denotes ]
T912 1282-1284 , denotes ,
T913 1284-1287 IN denotes for
T915 1288-1293 WDT denotes which
T916 1294-1307 JJ denotes physiological
T917 1308-1318 NNS denotes recordings
T918 1319-1320 -LRB- denotes [
T920 1320-1322 CD denotes 24
T921 1322-1323 , denotes ,
T922 1323-1325 CD denotes 36
T923 1325-1326 , denotes ,
T919 1326-1328 CD denotes 37
T924 1328-1329 -RRB- denotes ]
T925 1330-1333 CC denotes and
T926 1334-1342 NN denotes modeling
T927 1343-1347 NNS denotes data
T928 1347-1349 , denotes ,
T929 1349-1354 VBN denotes based
T930 1355-1357 IN denotes on
T931 1358-1361 DT denotes the
T933 1362-1366 RB denotes well
T935 1366-1367 HYPH denotes -
T934 1367-1372 VBN denotes known
T932 1373-1380 NN denotes anatomy
T936 1381-1382 -LRB- denotes [
T937 1382-1384 CD denotes 29
T938 1384-1385 -RRB- denotes ]
T939 1385-1387 , denotes ,
T914 1387-1394 VBP denotes provide
T940 1395-1405 JJ denotes additional
T941 1406-1413 NN denotes support
T942 1413-1414 . denotes .
T943 1414-1640 sentence denotes Such contrast enhancement may rest in large part on the particular properties of dendrodendritic synapses between the principal output neurons (mitral cells) and local inhibitory neurons (granule cells) of the olfactory bulb.
T944 1415-1419 JJ denotes Such
T946 1420-1428 NN denotes contrast
T945 1429-1440 NN denotes enhancement
T948 1441-1444 MD denotes may
T947 1445-1449 VB denotes rest
T949 1450-1452 IN denotes in
T950 1453-1458 JJ denotes large
T951 1459-1463 NN denotes part
T952 1464-1466 IN denotes on
T953 1467-1470 DT denotes the
T955 1471-1481 JJ denotes particular
T954 1482-1492 NNS denotes properties
T956 1493-1495 IN denotes of
T957 1496-1511 JJ denotes dendrodendritic
T958 1512-1520 NNS denotes synapses
T959 1521-1528 IN denotes between
T960 1529-1532 DT denotes the
T962 1533-1542 JJ denotes principal
T963 1543-1549 NN denotes output
T961 1550-1557 NNS denotes neurons
T964 1558-1559 -LRB- denotes (
T966 1559-1565 JJ denotes mitral
T965 1566-1571 NNS denotes cells
T654 1571-1572 -RRB- denotes )
T967 1573-1576 CC denotes and
T968 1577-1582 JJ denotes local
T970 1583-1593 JJ denotes inhibitory
T969 1594-1601 NNS denotes neurons
T971 1602-1603 -LRB- denotes (
T973 1603-1610 NN denotes granule
T972 1611-1616 NNS denotes cells
T974 1616-1617 -RRB- denotes )
T975 1618-1620 IN denotes of
T976 1621-1624 DT denotes the
T978 1625-1634 JJ denotes olfactory
T977 1635-1639 NN denotes bulb
T979 1639-1640 . denotes .
T980 1640-1973 sentence denotes In these distinct synapses, lateral and recurrent inhibition mediated by the gamma-aminobutyric acid-A system may be controlled by the activity of the closely appositioned glutamatergic part, perhaps triggering increased gamma-aminobutyric acid release by Ca2+ influx through glutamate-gated receptor channels ([38]; see also [39]).
T981 1641-1643 IN denotes In
T983 1644-1649 DT denotes these
T985 1650-1658 JJ denotes distinct
T984 1659-1667 NNS denotes synapses
T986 1667-1669 , denotes ,
T987 1669-1676 JJ denotes lateral
T989 1677-1680 CC denotes and
T990 1681-1690 JJ denotes recurrent
T988 1691-1701 NN denotes inhibition
T991 1702-1710 VBN denotes mediated
T992 1711-1713 IN denotes by
T993 1714-1717 DT denotes the
T995 1718-1723 NN denotes gamma
T997 1723-1724 HYPH denotes -
T996 1724-1736 JJ denotes aminobutyric
T998 1737-1741 NN denotes acid
T1000 1741-1742 HYPH denotes -
T999 1742-1743 NN denotes A
T994 1744-1750 NN denotes system
T1001 1751-1754 MD denotes may
T1002 1755-1757 VB denotes be
T982 1758-1768 VBN denotes controlled
T1003 1769-1771 IN denotes by
T1004 1772-1775 DT denotes the
T1005 1776-1784 NN denotes activity
T1006 1785-1787 IN denotes of
T1007 1788-1791 DT denotes the
T1009 1792-1799 RB denotes closely
T1010 1800-1812 VBN denotes appositioned
T1011 1813-1826 JJ denotes glutamatergic
T1008 1827-1831 NN denotes part
T1012 1831-1833 , denotes ,
T1013 1833-1840 RB denotes perhaps
T1014 1841-1851 VBG denotes triggering
T1015 1852-1861 VBN denotes increased
T1017 1862-1867 NN denotes gamma
T1019 1867-1868 HYPH denotes -
T1018 1868-1880 JJ denotes aminobutyric
T1020 1881-1885 NN denotes acid
T1016 1886-1893 NN denotes release
T1021 1894-1896 IN denotes by
T1022 1897-1900 NN denotes Ca2
T1024 1900-1901 SYM denotes +
T1023 1902-1908 NN denotes influx
T1025 1909-1916 IN denotes through
T1026 1917-1926 NN denotes glutamate
T1028 1926-1927 HYPH denotes -
T1027 1927-1932 VBN denotes gated
T1030 1933-1941 NN denotes receptor
T1029 1942-1950 NNS denotes channels
T1031 1951-1952 -LRB- denotes (
T1033 1952-1953 -LRB- denotes [
T1032 1953-1955 CD denotes 38
T1034 1955-1956 -RRB- denotes ]
T1035 1956-1957 : denotes ;
T1036 1958-1961 VB denotes see
T1037 1962-1966 RB denotes also
T1038 1967-1968 -LRB- denotes [
T1039 1968-1970 CD denotes 39
T1040 1970-1971 -RRB- denotes ]
T1041 1971-1972 -RRB- denotes )
T1042 1972-1973 . denotes .
T1043 1973-2383 sentence denotes Given that neuronal circuits underlying odor discrimination, as well as olfactory memory, rely on properties of fast excitatory neurotransmission mediated by α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptors (AMPARs), we sought to alter, by genetic means, the specific functional contribution of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) channels containing the dominant subunit GluR-B.
T1044 1974-1979 VBN denotes Given
T1046 1980-1984 IN denotes that
T1048 1985-1993 JJ denotes neuronal
T1049 1994-2002 NNS denotes circuits
T1050 2003-2013 VBG denotes underlying
T1051 2014-2018 NN denotes odor
T1052 2019-2033 NN denotes discrimination
T1053 2033-2035 , denotes ,
T1054 2035-2037 RB denotes as
T1056 2038-2042 RB denotes well
T1055 2043-2045 IN denotes as
T1057 2046-2055 JJ denotes olfactory
T1058 2056-2062 NN denotes memory
T1059 2062-2064 , denotes ,
T1047 2064-2068 VBP denotes rely
T1060 2069-2071 IN denotes on
T1061 2072-2082 NNS denotes properties
T1062 2083-2085 IN denotes of
T1063 2086-2090 JJ denotes fast
T1065 2091-2101 JJ denotes excitatory
T1064 2102-2119 NN denotes neurotransmission
T1066 2120-2128 VBN denotes mediated
T1067 2129-2131 IN denotes by
T1068 2132-2133 NN denotes α
T1070 2133-2134 HYPH denotes -
T1069 2134-2139 NN denotes amino
T1072 2139-2140 HYPH denotes -
T1073 2140-2141 CD denotes 3
T1075 2141-2142 HYPH denotes -
T1074 2142-2149 NN denotes hydroxy
T1076 2149-2150 HYPH denotes -
T1077 2150-2151 CD denotes 5
T1079 2151-2152 HYPH denotes -
T1078 2152-2158 NN denotes methyl
T1080 2158-2159 HYPH denotes -
T1081 2159-2160 CD denotes 4
T1082 2160-2161 HYPH denotes -
T1071 2161-2180 NN denotes isoxazolepropionate
T1083 2181-2190 NNS denotes receptors
T1084 2191-2192 -LRB- denotes (
T1085 2192-2198 NNS denotes AMPARs
T1086 2198-2199 -RRB- denotes )
T1087 2199-2201 , denotes ,
T1088 2201-2203 PRP denotes we
T1045 2204-2210 VBD denotes sought
T1089 2211-2213 TO denotes to
T1090 2214-2219 VB denotes alter
T1091 2219-2221 , denotes ,
T1092 2221-2223 IN denotes by
T1093 2224-2231 JJ denotes genetic
T1094 2232-2237 NNS denotes means
T1095 2237-2239 , denotes ,
T1096 2239-2242 DT denotes the
T1098 2243-2251 JJ denotes specific
T1099 2252-2262 JJ denotes functional
T1097 2263-2275 NN denotes contribution
T1100 2276-2278 IN denotes of
T1101 2279-2280 NN denotes α
T1103 2280-2281 HYPH denotes -
T1102 2281-2286 NN denotes amino
T1105 2286-2287 HYPH denotes -
T1106 2287-2288 CD denotes 3
T1108 2288-2289 HYPH denotes -
T1107 2289-2296 NN denotes hydroxy
T1109 2296-2297 HYPH denotes -
T1110 2297-2298 CD denotes 5
T1112 2298-2299 HYPH denotes -
T1111 2299-2305 NN denotes methyl
T1113 2305-2306 HYPH denotes -
T1114 2306-2307 CD denotes 4
T1115 2307-2308 HYPH denotes -
T1104 2308-2327 NN denotes isoxazolepropionate
T1117 2328-2329 -LRB- denotes (
T1118 2329-2333 NN denotes AMPA
T1119 2333-2334 -RRB- denotes )
T1116 2335-2343 NNS denotes channels
T1120 2344-2354 VBG denotes containing
T1121 2355-2358 DT denotes the
T1123 2359-2367 JJ denotes dominant
T1122 2368-2375 NN denotes subunit
T1124 2376-2380 NN denotes GluR
T1126 2380-2381 HYPH denotes -
T1125 2381-2382 NN denotes B
T1127 2382-2383 . denotes .
T1128 2383-2563 sentence denotes Of the four AMPAR constituents, GluR-A to D (GluR1 to 4), which form tetrameric channels with different binary subunit combinations, GluR-B is contained in the majority of AMPARs.
T1129 2384-2386 IN denotes Of
T1131 2387-2390 DT denotes the
T1133 2391-2395 CD denotes four
T1134 2396-2401 NN denotes AMPAR
T1132 2402-2414 NNS denotes constituents
T1135 2414-2416 , denotes ,
T1136 2416-2420 NN denotes GluR
T1138 2420-2421 HYPH denotes -
T1137 2421-2422 NN denotes A
T1139 2423-2425 IN denotes to
T1140 2426-2427 NN denotes D
T1141 2428-2429 -LRB- denotes (
T1142 2429-2434 NN denotes GluR1
T1143 2435-2437 IN denotes to
T1144 2438-2439 CD denotes 4
T1145 2439-2440 -RRB- denotes )
T1146 2440-2442 , denotes ,
T1147 2442-2447 WDT denotes which
T1148 2448-2452 VBP denotes form
T1149 2453-2463 JJ denotes tetrameric
T1150 2464-2472 NNS denotes channels
T1151 2473-2477 IN denotes with
T1152 2478-2487 JJ denotes different
T1154 2488-2494 JJ denotes binary
T1155 2495-2502 NN denotes subunit
T1153 2503-2515 NNS denotes combinations
T1156 2515-2517 , denotes ,
T1157 2517-2521 NN denotes GluR
T1159 2521-2522 HYPH denotes -
T1158 2522-2523 NN denotes B
T1160 2524-2526 VBZ denotes is
T1130 2527-2536 VBN denotes contained
T1161 2537-2539 IN denotes in
T1162 2540-2543 DT denotes the
T1163 2544-2552 NN denotes majority
T1164 2553-2555 IN denotes of
T1165 2556-2562 NNS denotes AMPARs
T1166 2562-2563 . denotes .
T1167 2563-2704 sentence denotes GluR-B is critically involved in the formation and trafficking of AMPARs, and dominates their ion conductance and gating properties [40–46].
T1168 2564-2568 NN denotes GluR
T1170 2568-2569 HYPH denotes -
T1169 2569-2570 NN denotes B
T1172 2571-2573 VBZ denotes is
T1173 2574-2584 RB denotes critically
T1171 2585-2593 VBN denotes involved
T1174 2594-2596 IN denotes in
T1175 2597-2600 DT denotes the
T1176 2601-2610 NN denotes formation
T1177 2611-2614 CC denotes and
T1178 2615-2626 NN denotes trafficking
T1179 2627-2629 IN denotes of
T1180 2630-2636 NNS denotes AMPARs
T1181 2636-2638 , denotes ,
T1182 2638-2641 CC denotes and
T1183 2642-2651 VBZ denotes dominates
T1184 2652-2657 PRP$ denotes their
T1186 2658-2661 NN denotes ion
T1185 2662-2673 NN denotes conductance
T1187 2674-2677 CC denotes and
T1188 2678-2684 NN denotes gating
T1189 2685-2695 NNS denotes properties
T1190 2696-2697 -LRB- denotes [
T1191 2697-2699 CD denotes 40
T1192 2699-2700 SYM denotes –
T1193 2700-2702 CD denotes 46
T1194 2702-2703 -RRB- denotes ]
T1195 2703-2704 . denotes .
T1196 2704-3030 sentence denotes Notably, the normally low Ca2+ permeability of AMPA channels in principal neurons is solely mediated by GluR-B, due to a unique arginine residue (R587) in the functionally critical glutamine/arginine (Q/R) site of the pore-forming segment M2 [44,47,48], resulting from RNA editing of GluR-B pre-mRNA ([49]; reviewed in [50]).
T1197 2705-2712 RB denotes Notably
T1199 2712-2714 , denotes ,
T1200 2714-2717 DT denotes the
T1202 2718-2726 RB denotes normally
T1203 2727-2730 JJ denotes low
T1204 2731-2734 NN denotes Ca2
T1205 2734-2735 SYM denotes +
T1201 2736-2748 NN denotes permeability
T1206 2749-2751 IN denotes of
T1207 2752-2756 NN denotes AMPA
T1208 2757-2765 NNS denotes channels
T1210 2766-2768 IN denotes in
T1212 2769-2778 JJ denotes principal
T1214 2779-2786 NNS denotes neurons
T1215 2787-2789 VBZ denotes is
T1216 2790-2796 RB denotes solely
T1198 2797-2805 VBN denotes mediated
T1217 2806-2808 IN denotes by
T1219 2809-2813 NN denotes GluR
T1221 2813-2814 HYPH denotes -
T1220 2814-2815 NN denotes B
T1222 2815-2817 , denotes ,
T1224 2817-2820 IN denotes due
T1225 2821-2823 IN denotes to
T1227 2824-2825 DT denotes a
T1229 2826-2832 JJ denotes unique
T1230 2833-2841 NN denotes arginine
T1228 2842-2849 NN denotes residue
T1231 2850-2851 -LRB- denotes (
T1232 2851-2855 NN denotes R587
T1233 2855-2856 -RRB- denotes )
T1234 2857-2859 IN denotes in
T1235 2860-2863 DT denotes the
T1237 2864-2876 RB denotes functionally
T1209 2877-2885 JJ denotes critical
T1238 2886-2895 NN denotes glutamine
T1240 2895-2896 HYPH denotes /
T1239 2896-2904 NN denotes arginine
T1241 2905-2906 -LRB- denotes (
T1243 2906-2907 NN denotes Q
T1244 2907-2908 HYPH denotes /
T1242 2908-2909 NN denotes R
T1245 2909-2910 -RRB- denotes )
T1236 2911-2915 NN denotes site
T1246 2916-2918 IN denotes of
T1247 2919-2922 DT denotes the
T1249 2923-2927 NN denotes pore
T1251 2927-2928 HYPH denotes -
T1250 2928-2935 VBG denotes forming
T1252 2936-2943 NN denotes segment
T1248 2944-2946 NN denotes M2
T1253 2947-2948 -LRB- denotes [
T1255 2948-2950 CD denotes 44
T1256 2950-2951 , denotes ,
T1257 2951-2953 CD denotes 47
T1258 2953-2954 , denotes ,
T1254 2954-2956 CD denotes 48
T1259 2956-2957 -RRB- denotes ]
T1260 2957-2959 , denotes ,
T1261 2959-2968 VBG denotes resulting
T1262 2969-2973 IN denotes from
T1263 2974-2977 NN denotes RNA
T1264 2978-2985 NN denotes editing
T1265 2986-2988 IN denotes of
T1266 2989-2993 NN denotes GluR
T1268 2993-2994 HYPH denotes -
T1267 2994-2995 NN denotes B
T1269 2996-3004 NN denotes pre-mRNA
T1270 3005-3006 -LRB- denotes (
T1272 3006-3007 -LRB- denotes [
T1271 3007-3009 CD denotes 49
T1273 3009-3010 -RRB- denotes ]
T1274 3010-3011 : denotes ;
T1275 3012-3020 VBN denotes reviewed
T1276 3021-3023 IN denotes in
T1277 3024-3025 -LRB- denotes [
T1278 3025-3027 CD denotes 50
T1279 3027-3028 -RRB- denotes ]
T1280 3028-3029 -RRB- denotes )
T1281 3029-3030 . denotes .
T1282 3030-3278 sentence denotes Hence, either GluR-B deficiency, or the expression of Q/R site-unedited GluR-B with a glutamine residue at the critical channel site, leads to increased Ca2+ permeability of AMPA channels, as amply demonstrated in gene-targeted mice [51,53,58,60].
T1283 3031-3036 RB denotes Hence
T1285 3036-3038 , denotes ,
T1286 3038-3044 CC denotes either
T1288 3045-3049 NN denotes GluR
T1290 3049-3050 HYPH denotes -
T1289 3050-3051 NN denotes B
T1287 3052-3062 NN denotes deficiency
T1291 3062-3064 , denotes ,
T1292 3064-3066 CC denotes or
T1293 3067-3070 DT denotes the
T1294 3071-3081 NN denotes expression
T1295 3082-3084 IN denotes of
T1296 3085-3086 NN denotes Q
T1298 3086-3087 HYPH denotes /
T1297 3087-3088 NN denotes R
T1300 3089-3093 NN denotes site
T1302 3093-3094 HYPH denotes -
T1301 3094-3102 JJ denotes unedited
T1303 3103-3107 NN denotes GluR
T1304 3107-3108 HYPH denotes -
T1299 3108-3109 NN denotes B
T1305 3110-3114 IN denotes with
T1306 3115-3116 DT denotes a
T1308 3117-3126 NN denotes glutamine
T1307 3127-3134 NN denotes residue
T1309 3135-3137 IN denotes at
T1310 3138-3141 DT denotes the
T1312 3142-3150 JJ denotes critical
T1313 3151-3158 NN denotes channel
T1311 3159-3163 NN denotes site
T1314 3163-3165 , denotes ,
T1284 3165-3170 VBZ denotes leads
T1315 3171-3173 IN denotes to
T1316 3174-3183 VBN denotes increased
T1318 3184-3187 NN denotes Ca2
T1319 3187-3188 SYM denotes +
T1317 3189-3201 NN denotes permeability
T1320 3202-3204 IN denotes of
T1321 3205-3209 NN denotes AMPA
T1322 3210-3218 NNS denotes channels
T1323 3218-3220 , denotes ,
T1324 3220-3222 IN denotes as
T1326 3223-3228 RB denotes amply
T1325 3229-3241 VBN denotes demonstrated
T1327 3242-3244 IN denotes in
T1328 3245-3249 NN denotes gene
T1330 3249-3250 HYPH denotes -
T1329 3250-3258 VBN denotes targeted
T1331 3259-3263 NNS denotes mice
T1332 3264-3265 -LRB- denotes [
T1334 3265-3267 CD denotes 51
T1335 3267-3268 , denotes ,
T1336 3268-3270 CD denotes 53
T1337 3270-3271 , denotes ,
T1338 3271-3273 CD denotes 58
T1339 3273-3274 , denotes ,
T1333 3274-3276 CD denotes 60
T1340 3276-3277 -RRB- denotes ]
T1341 3277-3278 . denotes .
T1342 3278-3412 sentence denotes Thus, the absence of GluR-B, or the expression of GluR-B(Q) in the olfactory bulb, may generate increased inhibition in mitral cells.
T1343 3279-3283 RB denotes Thus
T1345 3283-3285 , denotes ,
T1346 3285-3288 DT denotes the
T1347 3289-3296 NN denotes absence
T1348 3297-3299 IN denotes of
T1349 3300-3304 NN denotes GluR
T1351 3304-3305 HYPH denotes -
T1350 3305-3306 NN denotes B
T1352 3306-3308 , denotes ,
T1353 3308-3310 CC denotes or
T1354 3311-3314 DT denotes the
T1355 3315-3325 NN denotes expression
T1356 3326-3328 IN denotes of
T1357 3329-3333 NN denotes GluR
T1359 3333-3334 HYPH denotes -
T1360 3334-3335 NN denotes B
T1361 3335-3336 -LRB- denotes (
T1358 3336-3337 NN denotes Q
T1362 3337-3338 -RRB- denotes )
T1363 3339-3341 IN denotes in
T1364 3342-3345 DT denotes the
T1366 3346-3355 JJ denotes olfactory
T1365 3356-3360 NN denotes bulb
T1367 3360-3362 , denotes ,
T1368 3362-3365 MD denotes may
T1344 3366-3374 VB denotes generate
T1369 3375-3384 VBN denotes increased
T1370 3385-3395 NN denotes inhibition
T1371 3396-3398 IN denotes in
T1372 3399-3405 JJ denotes mitral
T1373 3406-3411 NNS denotes cells
T1374 3411-3412 . denotes .
T1375 3412-3735 sentence denotes Moreover, the ablation of GluR-B, but also changes in the extent of Q/R site editing of GluR-B, can alter the strength of excitatory synaptic transmission in the genetically addressed neuronal populations [51,58,60], thus potentially shifting the balance of excitatory and inhibitory transmission in the affected circuits.
T1376 3413-3421 RB denotes Moreover
T1378 3421-3423 , denotes ,
T1379 3423-3426 DT denotes the
T1380 3427-3435 NN denotes ablation
T1211 3436-3438 IN denotes of
T1381 3439-3443 NN denotes GluR
T1383 3443-3444 HYPH denotes -
T1382 3444-3445 NN denotes B
T1384 3445-3447 , denotes ,
T1385 3447-3450 CC denotes but
T1386 3451-3455 RB denotes also
T1387 3456-3463 NNS denotes changes
T1388 3464-3466 IN denotes in
T1389 3467-3470 DT denotes the
T1390 3471-3477 NN denotes extent
T1391 3478-3480 IN denotes of
T1392 3481-3482 NN denotes Q
T1394 3482-3483 HYPH denotes /
T1393 3483-3484 NN denotes R
T1396 3485-3489 NN denotes site
T1395 3490-3497 NN denotes editing
T1397 3498-3500 IN denotes of
T1398 3501-3505 NN denotes GluR
T1400 3505-3506 HYPH denotes -
T1399 3506-3507 NN denotes B
T1401 3507-3509 , denotes ,
T1402 3509-3512 MD denotes can
T1377 3513-3518 VB denotes alter
T1403 3519-3522 DT denotes the
T1404 3523-3531 NN denotes strength
T1405 3532-3534 IN denotes of
T1406 3535-3545 JJ denotes excitatory
T1408 3546-3554 JJ denotes synaptic
T1407 3555-3567 NN denotes transmission
T1409 3568-3570 IN denotes in
T1410 3571-3574 DT denotes the
T1412 3575-3586 RB denotes genetically
T1413 3587-3596 VBN denotes addressed
T1414 3597-3605 JJ denotes neuronal
T1411 3606-3617 NNS denotes populations
T1415 3618-3619 -LRB- denotes [
T1417 3619-3621 CD denotes 51
T1418 3621-3622 , denotes ,
T1419 3622-3624 CD denotes 58
T1420 3624-3625 , denotes ,
T1416 3625-3627 CD denotes 60
T1421 3627-3628 -RRB- denotes ]
T1422 3628-3630 , denotes ,
T1423 3630-3634 RB denotes thus
T1425 3635-3646 RB denotes potentially
T1424 3647-3655 VBG denotes shifting
T1426 3656-3659 DT denotes the
T1427 3660-3667 NN denotes balance
T1428 3668-3670 IN denotes of
T1429 3671-3681 JJ denotes excitatory
T1431 3682-3685 CC denotes and
T1432 3686-3696 JJ denotes inhibitory
T1430 3697-3709 NN denotes transmission
T1433 3710-3712 IN denotes in
T1434 3713-3716 DT denotes the
T1436 3717-3725 VBN denotes affected
T1435 3726-3734 NNS denotes circuits
T1437 3734-3735 . denotes .
T1438 3735-3885 sentence denotes Similarly, changes in synaptic plasticity due to Ca2+-permeable AMPARs [51,52,60], e.g., in piriform cortex, might alter odor memorization processes.
T1439 3736-3745 RB denotes Similarly
T1441 3745-3747 , denotes ,
T1442 3747-3754 NNS denotes changes
T1443 3755-3757 IN denotes in
T1213 3758-3766 JJ denotes synaptic
T1444 3767-3777 NN denotes plasticity
T1445 3778-3781 IN denotes due
T1446 3782-3784 IN denotes to
T1447 3785-3788 NN denotes Ca2
T1449 3788-3789 SYM denotes +
T1450 3789-3790 HYPH denotes -
T1448 3790-3799 JJ denotes permeable
T1451 3800-3806 NNS denotes AMPARs
T1452 3807-3808 -LRB- denotes [
T1454 3808-3810 CD denotes 51
T1455 3810-3811 , denotes ,
T1456 3811-3813 CD denotes 52
T1457 3813-3814 , denotes ,
T1453 3814-3816 CD denotes 60
T1458 3816-3817 -RRB- denotes ]
T1459 3817-3819 , denotes ,
T1460 3819-3823 FW denotes e.g.
T1462 3823-3825 , denotes ,
T1461 3825-3827 IN denotes in
T1463 3828-3836 JJ denotes piriform
T1464 3837-3843 NN denotes cortex
T1465 3843-3845 , denotes ,
T1466 3845-3850 MD denotes might
T1440 3851-3856 VB denotes alter
T1467 3857-3861 NN denotes odor
T1468 3862-3874 NN denotes memorization
T1469 3875-3884 NNS denotes processes
T1470 3884-3885 . denotes .
T1471 3885-4045 sentence denotes Thus, alterations of AMPAR properties in these brain regions will allow investigation and possibly separation of mechanisms underlying these behavioral traits.
T1472 3886-3890 RB denotes Thus
T1474 3890-3892 , denotes ,
T1475 3892-3903 NNS denotes alterations
T1476 3904-3906 IN denotes of
T1477 3907-3912 NN denotes AMPAR
T1478 3913-3923 NNS denotes properties
T1479 3924-3926 IN denotes in
T1480 3927-3932 DT denotes these
T1482 3933-3938 NN denotes brain
T1481 3939-3946 NNS denotes regions
T1483 3947-3951 MD denotes will
T1473 3952-3957 VB denotes allow
T1484 3958-3971 NN denotes investigation
T1485 3972-3975 CC denotes and
T1486 3976-3984 RB denotes possibly
T1487 3985-3995 NN denotes separation
T1488 3996-3998 IN denotes of
T1489 3999-4009 NNS denotes mechanisms
T1490 4010-4020 VBG denotes underlying
T1491 4021-4026 DT denotes these
T1493 4027-4037 JJ denotes behavioral
T1492 4038-4044 NNS denotes traits
T1494 4044-4045 . denotes .
T1495 4045-4311 sentence denotes Concerning this intended switch in AMPAR properties, mice lacking all GluR-B, however, show a widespread impairment in behavior, including lethargy, motor coordination problems, and deficits in exploratory activity [51], which preclude detailed behavioral analyses.
T1496 4046-4056 VBG denotes Concerning
T1498 4057-4061 DT denotes this
T1500 4062-4070 VBN denotes intended
T1499 4071-4077 NN denotes switch
T1501 4078-4080 IN denotes in
T1502 4081-4086 NN denotes AMPAR
T1503 4087-4097 NNS denotes properties
T1504 4097-4099 , denotes ,
T1505 4099-4103 NNS denotes mice
T1506 4104-4111 VBG denotes lacking
T1507 4112-4115 DT denotes all
T1509 4116-4120 NN denotes GluR
T1510 4120-4121 HYPH denotes -
T1508 4121-4122 NN denotes B
T1511 4122-4124 , denotes ,
T1512 4124-4131 RB denotes however
T1513 4131-4133 , denotes ,
T1497 4133-4137 VBP denotes show
T1514 4138-4139 DT denotes a
T1516 4140-4150 JJ denotes widespread
T1515 4151-4161 NN denotes impairment
T1517 4162-4164 IN denotes in
T1518 4165-4173 NN denotes behavior
T1519 4173-4175 , denotes ,
T1520 4175-4184 VBG denotes including
T1521 4185-4193 NN denotes lethargy
T1522 4193-4195 , denotes ,
T1523 4195-4200 NN denotes motor
T1524 4201-4213 NN denotes coordination
T1525 4214-4222 NNS denotes problems
T1526 4222-4224 , denotes ,
T1527 4224-4227 CC denotes and
T1528 4228-4236 NNS denotes deficits
T1529 4237-4239 IN denotes in
T1530 4240-4251 JJ denotes exploratory
T1531 4252-4260 NN denotes activity
T1532 4261-4262 -LRB- denotes [
T1533 4262-4264 CD denotes 51
T1534 4264-4265 -RRB- denotes ]
T1535 4265-4267 , denotes ,
T1536 4267-4272 WDT denotes which
T1537 4273-4281 VBP denotes preclude
T1538 4282-4290 JJ denotes detailed
T1540 4291-4301 JJ denotes behavioral
T1539 4302-4310 NNS denotes analyses
T1541 4310-4311 . denotes .
T1542 4311-4481 sentence denotes Similarly, mice expressing (in the entire brain) a substantial part of the GluR-B population in the Q/R site-unedited form become seizure-prone and die prematurely [53].
T1543 4312-4321 RB denotes Similarly
T1545 4321-4323 , denotes ,
T1546 4323-4327 NNS denotes mice
T1547 4328-4338 VBG denotes expressing
T1548 4339-4340 -LRB- denotes (
T1549 4340-4342 IN denotes in
T1550 4343-4346 DT denotes the
T1552 4347-4353 JJ denotes entire
T1551 4354-4359 NN denotes brain
T1553 4359-4360 -RRB- denotes )
T1554 4361-4362 DT denotes a
T1556 4363-4374 JJ denotes substantial
T1555 4375-4379 NN denotes part
T1557 4380-4382 IN denotes of
T1558 4383-4386 DT denotes the
T1560 4387-4391 NN denotes GluR
T1562 4391-4392 HYPH denotes -
T1561 4392-4393 NN denotes B
T1559 4394-4404 NN denotes population
T1563 4405-4407 IN denotes in
T1564 4408-4411 DT denotes the
T1566 4412-4413 NN denotes Q
T1568 4413-4414 HYPH denotes /
T1567 4414-4415 NN denotes R
T1569 4416-4420 NN denotes site
T1571 4420-4421 HYPH denotes -
T1570 4421-4429 JJ denotes unedited
T1565 4430-4434 NN denotes form
T1544 4435-4441 VBP denotes become
T1572 4442-4449 NN denotes seizure
T1574 4449-4450 HYPH denotes -
T1573 4450-4455 JJ denotes prone
T1575 4456-4459 CC denotes and
T1576 4460-4463 VBP denotes die
T1577 4464-4475 RB denotes prematurely
T1578 4476-4477 -LRB- denotes [
T1579 4477-4479 CD denotes 53
T1580 4479-4480 -RRB- denotes ]
T1581 4480-4481 . denotes .
T1582 4481-4800 sentence denotes Some of these problems can be partially overcome by use of spatially and temporally restricted expression systems [54–56], in particular the Cre-lox system, with Cre-recombinase expression in defined brain areas of gene-targeted mice carrying GluR-B alleles marked by loxP sites for Cre-mediated recombination [55,57].
T1583 4482-4486 DT denotes Some
T1585 4487-4489 IN denotes of
T1586 4490-4495 DT denotes these
T1587 4496-4504 NNS denotes problems
T1588 4505-4508 MD denotes can
T1589 4509-4511 VB denotes be
T1590 4512-4521 RB denotes partially
T1584 4522-4530 VBN denotes overcome
T1591 4531-4533 IN denotes by
T1592 4534-4537 NN denotes use
T1593 4538-4540 IN denotes of
T1594 4541-4550 RB denotes spatially
T1596 4551-4554 CC denotes and
T1597 4555-4565 RB denotes temporally
T1595 4566-4576 VBN denotes restricted
T1599 4577-4587 NN denotes expression
T1598 4588-4595 NNS denotes systems
T1600 4596-4597 -LRB- denotes [
T1601 4597-4599 CD denotes 54
T1602 4599-4600 SYM denotes –
T1603 4600-4602 CD denotes 56
T1604 4602-4603 -RRB- denotes ]
T1605 4603-4605 , denotes ,
T1606 4605-4607 IN denotes in
T1608 4608-4618 JJ denotes particular
T1609 4619-4622 DT denotes the
T1610 4623-4626 NN denotes Cre
T1612 4626-4627 HYPH denotes -
T1611 4627-4630 NN denotes lox
T1607 4631-4637 NN denotes system
T1613 4637-4639 , denotes ,
T1614 4639-4643 IN denotes with
T1616 4644-4647 NN denotes Cre
T1618 4647-4648 HYPH denotes -
T1617 4648-4659 NN denotes recombinase
T1619 4660-4670 NN denotes expression
T1620 4671-4673 IN denotes in
T1621 4674-4681 VBN denotes defined
T1623 4682-4687 NN denotes brain
T1622 4688-4693 NNS denotes areas
T1624 4694-4696 IN denotes of
T1625 4697-4701 NN denotes gene
T1627 4701-4702 HYPH denotes -
T1626 4702-4710 VBN denotes targeted
T1628 4711-4715 NNS denotes mice
T1629 4716-4724 VBG denotes carrying
T1630 4725-4729 NN denotes GluR
T1632 4729-4730 HYPH denotes -
T1631 4730-4731 NN denotes B
T1633 4732-4739 NNS denotes alleles
T1615 4740-4746 VBN denotes marked
T1634 4747-4749 IN denotes by
T1635 4750-4754 NN denotes loxP
T1636 4755-4760 NNS denotes sites
T1637 4761-4764 IN denotes for
T1638 4765-4768 NN denotes Cre
T1640 4768-4769 HYPH denotes -
T1639 4769-4777 VBN denotes mediated
T1641 4778-4791 NN denotes recombination
T1642 4792-4793 -LRB- denotes [
T1218 4793-4795 CD denotes 55
T1644 4795-4796 , denotes ,
T1643 4796-4798 CD denotes 57
T1645 4798-4799 -RRB- denotes ]
T1646 4799-4800 . denotes .
T1647 4800-4960 sentence denotes Indeed, restricting the expression of Q/R site-unedited GluR-B to forebrain resulted in almost normal lifespan and an only weakly seizure-prone phenotype [58].
T1648 4801-4807 RB denotes Indeed
T1650 4807-4809 , denotes ,
T1651 4809-4820 VBG denotes restricting
T1652 4821-4824 DT denotes the
T1653 4825-4835 NN denotes expression
T1654 4836-4838 IN denotes of
T1655 4839-4840 NN denotes Q
T1657 4840-4841 HYPH denotes /
T1656 4841-4842 NN denotes R
T1659 4843-4847 NN denotes site
T1661 4847-4848 HYPH denotes -
T1660 4848-4856 JJ denotes unedited
T1662 4857-4861 NN denotes GluR
T1663 4861-4862 HYPH denotes -
T1658 4862-4863 NN denotes B
T1664 4864-4866 IN denotes to
T1665 4867-4876 NN denotes forebrain
T1649 4877-4885 VBD denotes resulted
T1666 4886-4888 IN denotes in
T1667 4889-4895 RB denotes almost
T1668 4896-4902 JJ denotes normal
T1669 4903-4911 NN denotes lifespan
T1670 4912-4915 CC denotes and
T1671 4916-4918 DT denotes an
T1673 4919-4923 RB denotes only
T1674 4924-4930 RB denotes weakly
T1676 4931-4938 NN denotes seizure
T1677 4938-4939 HYPH denotes -
T1675 4939-4944 JJ denotes prone
T1672 4945-4954 NN denotes phenotype
T1678 4955-4956 -LRB- denotes [
T1679 4956-4958 CD denotes 58
T1680 4958-4959 -RRB- denotes ]
T1681 4959-4960 . denotes .
T1682 4960-5171 sentence denotes Mice with forebrain-specific GluR-B depletion appeared almost completely normal throughout life with no developmental abnormalities, thus permitting a detailed, quantitative investigation of olfactory behavior.
T1683 4961-4965 NNS denotes Mice
T1685 4966-4970 IN denotes with
T1686 4971-4980 NN denotes forebrain
T1688 4980-4981 HYPH denotes -
T1687 4981-4989 JJ denotes specific
T1690 4990-4994 NN denotes GluR
T1692 4994-4995 HYPH denotes -
T1691 4995-4996 NN denotes B
T1689 4997-5006 NN denotes depletion
T1684 5007-5015 VBD denotes appeared
T1693 5016-5022 RB denotes almost
T1694 5023-5033 RB denotes completely
T1695 5034-5040 JJ denotes normal
T1696 5041-5051 IN denotes throughout
T1697 5052-5056 NN denotes life
T1698 5057-5061 IN denotes with
T1699 5062-5064 DT denotes no
T1701 5065-5078 JJ denotes developmental
T1700 5079-5092 NNS denotes abnormalities
T1702 5092-5094 , denotes ,
T1703 5094-5098 RB denotes thus
T1704 5099-5109 VBG denotes permitting
T1705 5110-5111 DT denotes a
T1707 5112-5120 VBN denotes detailed
T1708 5120-5122 , denotes ,
T1709 5122-5134 JJ denotes quantitative
T1706 5135-5148 NN denotes investigation
T1710 5149-5151 IN denotes of
T1711 5152-5161 JJ denotes olfactory
T1712 5162-5170 NN denotes behavior
T1713 5170-5171 . denotes .
T1714 5171-5450 sentence denotes To allow for the mechanistic separation of olfactory learning, discrimination, and memory, we exploited a well-known phenomenon of transgenes, which concerns heterogeneous expression among different founder lines and even among genetically identical individuals of a given line.
T1715 5172-5174 TO denotes To
T1716 5175-5180 VB denotes allow
T1718 5181-5184 IN denotes for
T1719 5185-5188 DT denotes the
T1721 5189-5200 JJ denotes mechanistic
T1720 5201-5211 NN denotes separation
T1722 5212-5214 IN denotes of
T1723 5215-5224 JJ denotes olfactory
T1724 5225-5233 NN denotes learning
T1725 5233-5235 , denotes ,
T1726 5235-5249 NN denotes discrimination
T1727 5249-5251 , denotes ,
T1728 5251-5254 CC denotes and
T1729 5255-5261 NN denotes memory
T1223 5261-5263 , denotes ,
T1730 5263-5265 PRP denotes we
T1717 5266-5275 VBD denotes exploited
T1731 5276-5277 DT denotes a
T1733 5278-5282 RB denotes well
T1735 5282-5283 HYPH denotes -
T1734 5283-5288 VBN denotes known
T1732 5289-5299 NN denotes phenomenon
T1736 5300-5302 IN denotes of
T1737 5303-5313 NNS denotes transgenes
T1738 5313-5315 , denotes ,
T1739 5315-5320 WDT denotes which
T1740 5321-5329 VBZ denotes concerns
T1741 5330-5343 JJ denotes heterogeneous
T1742 5344-5354 NN denotes expression
T1743 5355-5360 IN denotes among
T1744 5361-5370 JJ denotes different
T1746 5371-5378 NN denotes founder
T1745 5379-5384 NNS denotes lines
T1747 5385-5388 CC denotes and
T1748 5389-5393 RB denotes even
T1749 5394-5399 IN denotes among
T1750 5400-5411 RB denotes genetically
T1751 5412-5421 JJ denotes identical
T1752 5422-5433 NNS denotes individuals
T1753 5434-5436 IN denotes of
T1754 5437-5438 DT denotes a
T1756 5439-5444 JJ denotes given
T1755 5445-5449 NN denotes line
T1757 5449-5450 . denotes .
T1758 5450-5681 sentence denotes Although such “mosaic” expression is usually undesired, here we took advantage of it by ablating GluR-B via gene-targeted, floxed GluR-B alleles with the help of a transgenic mouse line with variegated Cre expression in forebrain.
T1759 5451-5459 IN denotes Although
T1761 5460-5464 JJ denotes such
T1763 5465-5466 `` denotes “
T1764 5466-5472 NN denotes mosaic
T1765 5472-5473 '' denotes ”
T1762 5474-5484 NN denotes expression
T1760 5485-5487 VBZ denotes is
T1767 5488-5495 RB denotes usually
T1768 5496-5505 JJ denotes undesired
T1769 5505-5507 , denotes ,
T1770 5507-5511 RB denotes here
T1771 5512-5514 PRP denotes we
T1766 5515-5519 VBD denotes took
T1772 5520-5529 NN denotes advantage
T1773 5530-5532 IN denotes of
T1774 5533-5535 PRP denotes it
T1775 5536-5538 IN denotes by
T1776 5539-5547 VBG denotes ablating
T1777 5548-5552 NN denotes GluR
T1779 5552-5553 HYPH denotes -
T1778 5553-5554 NN denotes B
T1780 5555-5558 IN denotes via
T1781 5559-5563 NN denotes gene
T1783 5563-5564 HYPH denotes -
T1782 5564-5572 VBN denotes targeted
T1785 5572-5574 , denotes ,
T1786 5574-5580 VBN denotes floxed
T1787 5581-5585 NN denotes GluR
T1789 5585-5586 HYPH denotes -
T1788 5586-5587 NN denotes B
T1784 5588-5595 NNS denotes alleles
T1790 5596-5600 IN denotes with
T1791 5601-5604 DT denotes the
T1792 5605-5609 NN denotes help
T1793 5610-5612 IN denotes of
T1794 5613-5614 DT denotes a
T1796 5615-5625 JJ denotes transgenic
T1797 5626-5631 NN denotes mouse
T1795 5632-5636 NN denotes line
T1798 5637-5641 IN denotes with
T1799 5642-5652 VBN denotes variegated
T1801 5653-5656 NN denotes Cre
T1800 5657-5667 NN denotes expression
T1802 5668-5670 IN denotes in
T1803 5671-5680 NN denotes forebrain
T1804 5680-5681 . denotes .
T1805 5681-5861 sentence denotes By correlating GluR-B levels in olfaction-related brain regions with quantitative behavioral data, we investigated the dependence on GluR-B of olfactory discrimination and memory.
T1806 5682-5684 IN denotes By
T1808 5685-5696 VBG denotes correlating
T1809 5697-5701 NN denotes GluR
T1811 5701-5702 HYPH denotes -
T1810 5702-5703 NN denotes B
T1812 5704-5710 NNS denotes levels
T1813 5711-5713 IN denotes in
T1814 5714-5723 NN denotes olfaction
T1816 5723-5724 HYPH denotes -
T1815 5724-5731 VBN denotes related
T1818 5732-5737 NN denotes brain
T1817 5738-5745 NNS denotes regions
T1819 5746-5750 IN denotes with
T1820 5751-5763 JJ denotes quantitative
T1822 5764-5774 JJ denotes behavioral
T1821 5775-5779 NNS denotes data
T1823 5779-5781 , denotes ,
T1824 5781-5783 PRP denotes we
T1807 5784-5796 VBD denotes investigated
T1825 5797-5800 DT denotes the
T1826 5801-5811 NN denotes dependence
T1827 5812-5814 IN denotes on
T1828 5815-5819 NN denotes GluR
T1830 5819-5820 HYPH denotes -
T1829 5820-5821 NN denotes B
T1831 5822-5824 IN denotes of
T1832 5825-5834 JJ denotes olfactory
T1833 5835-5849 NN denotes discrimination
T1834 5850-5853 CC denotes and
T1835 5854-5860 NN denotes memory
T1836 5860-5861 . denotes .
T1837 5861-6047 sentence denotes Moreover, to delineate the brain areas involved in these distinctive olfactory processes we used transgenic “rescue” of GluR-B ablation, specifically in piriform cortex and hippocampus.
T1838 5862-5870 RB denotes Moreover
T1840 5870-5872 , denotes ,
T1841 5872-5874 TO denotes to
T1842 5875-5884 VB denotes delineate
T1843 5885-5888 DT denotes the
T1845 5889-5894 NN denotes brain
T1844 5895-5900 NNS denotes areas
T1846 5901-5909 VBN denotes involved
T1847 5910-5912 IN denotes in
T1848 5913-5918 DT denotes these
T1850 5919-5930 JJ denotes distinctive
T1851 5931-5940 JJ denotes olfactory
T1849 5941-5950 NNS denotes processes
T1852 5951-5953 PRP denotes we
T1839 5954-5958 VBD denotes used
T1853 5959-5969 JJ denotes transgenic
T1226 5970-5971 `` denotes “
T1854 5971-5977 NN denotes rescue
T1855 5977-5978 '' denotes ”
T1856 5979-5981 IN denotes of
T1857 5982-5986 NN denotes GluR
T1859 5986-5987 HYPH denotes -
T1858 5987-5988 NN denotes B
T1860 5989-5997 NN denotes ablation
T1861 5997-5999 , denotes ,
T1862 5999-6011 RB denotes specifically
T1863 6012-6014 IN denotes in
T1864 6015-6023 JJ denotes piriform
T1865 6024-6030 NN denotes cortex
T1866 6031-6034 CC denotes and
T1867 6035-6046 NN denotes hippocampus
T1868 6046-6047 . denotes .
T1869 6047-6237 sentence denotes These efforts allowed us to dissect, both spatially and mechanistically, the role of GluR-B-mediated AMPAR properties in selected brain regions in odor learning, discrimination, and memory.
T1870 6048-6053 DT denotes These
T1871 6054-6061 NNS denotes efforts
T1872 6062-6069 VBD denotes allowed
T1873 6070-6072 PRP denotes us
T1875 6073-6075 TO denotes to
T1874 6076-6083 VB denotes dissect
T1876 6083-6085 , denotes ,
T1877 6085-6089 DT denotes both
T1878 6090-6099 RB denotes spatially
T1879 6100-6103 CC denotes and
T1880 6104-6119 RB denotes mechanistically
T1881 6119-6121 , denotes ,
T1882 6121-6124 DT denotes the
T1883 6125-6129 NN denotes role
T1884 6130-6132 IN denotes of
T1885 6133-6137 NN denotes GluR
T1887 6137-6138 HYPH denotes -
T1886 6138-6139 NN denotes B
T1889 6139-6140 HYPH denotes -
T1888 6140-6148 VBN denotes mediated
T1891 6149-6154 NN denotes AMPAR
T1890 6155-6165 NNS denotes properties
T1892 6166-6168 IN denotes in
T1893 6169-6177 VBN denotes selected
T1895 6178-6183 NN denotes brain
T1894 6184-6191 NNS denotes regions
T1896 6192-6194 IN denotes in
T1897 6195-6199 NN denotes odor
T1898 6200-6208 NN denotes learning
T1899 6208-6210 , denotes ,
T1900 6210-6224 NN denotes discrimination
T1901 6224-6226 , denotes ,
T1902 6226-6229 CC denotes and
T1903 6230-6236 NN denotes memory
T1904 6236-6237 . denotes .
R1000 T1460 T1461 advmod e.g.,in
R1001 T1461 T1451 prep in,AMPARs
R1002 T1459 T1451 punct ", ",AMPARs
R1003 T1463 T1464 amod piriform,cortex
R1004 T1464 T1461 pobj cortex,in
R1005 T1462 T1461 punct ", ",in
R1006 T1466 T1440 aux might,alter
R1007 T1465 T1440 punct ", ",alter
R1008 T1468 T1469 compound memorization,processes
R1009 T1467 T1468 compound odor,memorization
R1010 T1470 T1440 punct .,alter
R1011 T1469 T1440 dobj processes,alter
R1012 T1472 T1473 advmod Thus,allow
R1013 T1475 T1473 nsubj alterations,allow
R1014 T1476 T1475 prep of,alterations
R1015 T1474 T1473 punct ", ",allow
R1016 T1478 T1476 pobj properties,of
R1017 T1479 T1475 prep in,alterations
R1018 T1477 T1478 compound AMPAR,properties
R1019 T1481 T1479 pobj regions,in
R1020 T1480 T1481 det these,regions
R1021 T1483 T1473 aux will,allow
R1022 T1484 T1473 dobj investigation,allow
R1023 T1482 T1481 compound brain,regions
R1024 T1486 T1487 advmod possibly,separation
R1025 T1485 T1484 cc and,investigation
R1026 T1488 T1484 prep of,investigation
R1027 T1487 T1484 conj separation,investigation
R1028 T1490 T1489 acl underlying,mechanisms
R1029 T1491 T1492 det these,traits
R1030 T1489 T1488 pobj mechanisms,of
R1031 T1493 T1492 amod behavioral,traits
R1032 T1492 T1490 dobj traits,underlying
R1033 T1496 T1497 prep Concerning,show
R1034 T1499 T1496 pobj switch,Concerning
R1035 T1494 T1473 punct .,allow
R1036 T1500 T1499 amod intended,switch
R1037 T1498 T1499 det this,switch
R1038 T1502 T1503 compound AMPAR,properties
R1039 T1501 T1499 prep in,switch
R1040 T1504 T1497 punct ", ",show
R1041 T1505 T1497 nsubj mice,show
R1042 T1503 T1501 pobj properties,in
R1043 T1507 T1508 det all,B
R1044 T1506 T1505 acl lacking,mice
R1045 T1509 T1508 compound GluR,B
R1046 T1510 T1508 punct -,B
R1047 T1508 T1506 dobj B,lacking
R1048 T1512 T1497 advmod however,show
R1049 T1511 T1497 punct ", ",show
R1050 T1514 T1515 det a,impairment
R1051 T1515 T1497 dobj impairment,show
R1052 T1513 T1497 punct ", ",show
R1053 T1517 T1515 prep in,impairment
R1054 T1516 T1515 amod widespread,impairment
R1055 T1519 T1515 punct ", ",impairment
R1056 T1520 T1515 prep including,impairment
R1057 T1518 T1517 pobj behavior,in
R1058 T1522 T1521 punct ", ",lethargy
R1059 T1523 T1524 compound motor,coordination
R1060 T1521 T1520 pobj lethargy,including
R1061 T1525 T1521 conj problems,lethargy
R1062 T1526 T1525 punct ", ",problems
R1063 T1524 T1525 compound coordination,problems
R1064 T1528 T1525 conj deficits,problems
R1065 T1529 T1528 prep in,deficits
R1066 T1527 T1525 cc and,problems
R1067 T1531 T1529 pobj activity,in
R1068 T1530 T1531 amod exploratory,activity
R1069 T1533 T1528 parataxis 51,deficits
R1070 T1534 T1533 punct ],51
R1071 T1532 T1533 punct [,51
R1072 T1536 T1537 dep which,preclude
R1073 T1537 T1528 relcl preclude,deficits
R1074 T1535 T1528 punct ", ",deficits
R1075 T1539 T1537 dobj analyses,preclude
R1076 T1538 T1539 amod detailed,analyses
R1077 T1541 T1497 punct .,show
R1078 T1540 T1539 amod behavioral,analyses
R1079 T1543 T1544 advmod Similarly,become
R1080 T1546 T1544 nsubj mice,become
R1081 T1547 T1546 acl expressing,mice
R1082 T1548 T1547 punct (,expressing
R1083 T1549 T1547 prep in,expressing
R1084 T1545 T1544 punct ", ",become
R1085 T1551 T1549 pobj brain,in
R1086 T1552 T1551 amod entire,brain
R1087 T1550 T1551 det the,brain
R1088 T1554 T1555 det a,part
R1089 T1553 T1547 punct ),expressing
R1090 T1556 T1555 amod substantial,part
R1091 T1555 T1547 dobj part,expressing
R1092 T1558 T1559 det the,population
R1093 T1559 T1557 pobj population,of
R1094 T1557 T1555 prep of,part
R1095 T1561 T1559 compound B,population
R1096 T1562 T1561 punct -,B
R1097 T1560 T1561 compound GluR,B
R1098 T1564 T1565 det the,form
R1099 T1563 T1547 prep in,expressing
R1100 T1566 T1567 nmod Q,R
R1101 T1567 T1565 nmod R,form
R1102 T1565 T1563 pobj form,in
R1103 T1569 T1570 npadvmod site,unedited
R1104 T1570 T1565 amod unedited,form
R1105 T1568 T1567 punct /,R
R1106 T1572 T1573 npadvmod seizure,prone
R1107 T1571 T1570 punct -,unedited
R1108 T1574 T1573 punct -,prone
R1109 T1575 T1544 cc and,become
R1110 T1573 T1544 acomp prone,become
R1111 T1577 T1576 advmod prematurely,die
R1112 T1578 T1579 punct [,53
R1113 T1576 T1544 conj die,become
R1114 T1580 T1579 punct ],53
R1115 T1579 T1576 parataxis 53,die
R1116 T1583 T1584 nsubjpass Some,overcome
R1117 T1581 T1544 punct .,become
R1118 T1585 T1583 prep of,Some
R1119 T1586 T1587 det these,problems
R1120 T1588 T1584 aux can,overcome
R1121 T1589 T1584 auxpass be,overcome
R1122 T1587 T1585 pobj problems,of
R1123 T1591 T1584 prep by,overcome
R1124 T1590 T1584 advmod partially,overcome
R1125 T1593 T1592 prep of,use
R1126 T1594 T1595 advmod spatially,restricted
R1127 T1595 T1598 amod restricted,systems
R1128 T1592 T1591 pobj use,by
R1129 T1597 T1594 conj temporally,spatially
R1130 T1598 T1593 pobj systems,of
R1131 T1596 T1594 cc and,spatially
R1132 T1600 T1601 punct [,54
R1133 T1601 T1598 parataxis 54,systems
R1134 T1599 T1598 compound expression,systems
R1135 T1603 T1601 prep 56,54
R1136 T1604 T1601 punct ],54
R1137 T1602 T1603 punct –,56
R1138 T1606 T1607 prep in,system
R1139 T1605 T1598 punct ", ",systems
R1140 T1608 T1606 amod particular,in
R1141 T1609 T1607 det the,system
R1142 T1610 T1611 compound Cre,lox
R1143 T1607 T1598 appos system,systems
R1144 T1612 T1611 punct -,lox
R1145 T1613 T1584 punct ", ",overcome
R1146 T1611 T1607 compound lox,system
R1147 T1615 T1584 advcl marked,overcome
R1148 T1614 T1615 mark with,marked
R1149 T1617 T1619 compound recombinase,expression
R1150 T1618 T1617 punct -,recombinase
R1151 T1619 T1615 nsubj expression,marked
R1152 T1616 T1617 compound Cre,recombinase
R1153 T1621 T1622 amod defined,areas
R1154 T1620 T1619 prep in,expression
R1155 T1623 T1622 compound brain,areas
R1156 T1624 T1622 prep of,areas
R1157 T1622 T1620 pobj areas,in
R1158 T1626 T1628 amod targeted,mice
R1159 T1625 T1626 npadvmod gene,targeted
R1160 T1628 T1624 pobj mice,of
R1161 T1627 T1626 punct -,targeted
R1162 T1630 T1631 compound GluR,B
R1163 T1631 T1633 compound B,alleles
R1164 T1629 T1628 acl carrying,mice
R1165 T1633 T1629 dobj alleles,carrying
R1166 T1632 T1631 punct -,B
R1167 T1635 T1636 compound loxP,sites
R1168 T1636 T1634 pobj sites,by
R1169 T1634 T1615 agent by,marked
R1170 T1638 T1639 npadvmod Cre,mediated
R1171 T1637 T1636 prep for,sites
R1172 T1640 T1639 punct -,mediated
R1173 T1641 T1637 pobj recombination,for
R1174 T1639 T1641 amod mediated,recombination
R1175 T1643 T1584 parataxis 57,overcome
R1176 T1642 T1643 punct [,57
R1177 T1645 T1643 punct ],57
R1178 T1646 T1584 punct .,overcome
R1179 T1644 T1643 punct ",",57
R1180 T1648 T1649 advmod Indeed,resulted
R1181 T1650 T1649 punct ", ",resulted
R1182 T1652 T1653 det the,expression
R1183 T1653 T1651 dobj expression,restricting
R1184 T1651 T1649 csubj restricting,resulted
R1185 T1655 T1656 nmod Q,R
R1186 T1656 T1658 nmod R,B
R1187 T1654 T1653 prep of,expression
R1188 T1658 T1654 pobj B,of
R1189 T1657 T1656 punct /,R
R1190 T1660 T1658 amod unedited,B
R1191 T1659 T1660 npadvmod site,unedited
R1192 T1662 T1658 compound GluR,B
R1193 T1663 T1658 punct -,B
R1194 T1661 T1660 punct -,unedited
R1195 T1665 T1664 pobj forebrain,to
R1196 T1666 T1649 prep in,resulted
R1197 T1664 T1651 prep to,restricting
R1198 T1668 T1669 amod normal,lifespan
R1199 T1669 T1666 pobj lifespan,in
R1200 T1667 T1668 advmod almost,normal
R1201 T1671 T1672 det an,phenotype
R1202 T1672 T1669 conj phenotype,lifespan
R1203 T1670 T1669 cc and,lifespan
R1204 T1674 T1675 advmod weakly,prone
R1205 T1675 T1672 amod prone,phenotype
R1206 T1673 T1674 advmod only,weakly
R1207 T1677 T1675 punct -,prone
R1208 T1676 T1675 npadvmod seizure,prone
R1209 T1679 T1649 parataxis 58,resulted
R1210 T1678 T1679 punct [,58
R1211 T1681 T1649 punct .,resulted
R1212 T1680 T1679 punct ],58
R1213 T1683 T1684 nsubj Mice,appeared
R1214 T1685 T1683 prep with,Mice
R1215 T1686 T1687 npadvmod forebrain,specific
R1216 T1688 T1687 punct -,specific
R1217 T1689 T1685 pobj depletion,with
R1218 T1687 T1689 amod specific,depletion
R1219 T1690 T1691 compound GluR,B
R1220 T1692 T1691 punct -,B
R1221 T1693 T1694 advmod almost,completely
R1222 T1691 T1689 compound B,depletion
R1223 T1695 T1684 oprd normal,appeared
R1224 T1696 T1684 prep throughout,appeared
R1225 T1694 T1695 advmod completely,normal
R1226 T1698 T1684 prep with,appeared
R1227 T1699 T1700 det no,abnormalities
R1228 T1697 T1696 pobj life,throughout
R1229 T1701 T1700 amod developmental,abnormalities
R1230 T1702 T1684 punct ", ",appeared
R1231 T1700 T1698 pobj abnormalities,with
R1232 T1704 T1684 advcl permitting,appeared
R1233 T1703 T1704 advmod thus,permitting
R1234 T1706 T1704 dobj investigation,permitting
R1235 T1705 T1706 det a,investigation
R1236 T1708 T1706 punct ", ",investigation
R1237 T1709 T1706 amod quantitative,investigation
R1238 T1707 T1706 amod detailed,investigation
R1239 T1711 T1712 amod olfactory,behavior
R1240 T1712 T1710 pobj behavior,of
R1241 T1710 T1706 prep of,investigation
R1242 T1715 T1716 aux To,allow
R1243 T1713 T1684 punct .,appeared
R1244 T1718 T1716 prep for,allow
R1245 T1716 T1717 advcl allow,exploited
R1246 T1720 T1718 pobj separation,for
R1247 T1721 T1720 amod mechanistic,separation
R1248 T1719 T1720 det the,separation
R1249 T1723 T1724 amod olfactory,learning
R1250 T1722 T1720 prep of,separation
R1251 T1725 T1724 punct ", ",learning
R1252 T1724 T1722 pobj learning,of
R1253 T1727 T1726 punct ", ",discrimination
R1254 T1728 T1726 cc and,discrimination
R1255 T1726 T1724 conj discrimination,learning
R1256 T1730 T1717 nsubj we,exploited
R1257 T1731 T1732 det a,phenomenon
R1258 T1729 T1726 conj memory,discrimination
R1259 T1733 T1734 advmod well,known
R1260 T1734 T1732 amod known,phenomenon
R1261 T1732 T1717 dobj phenomenon,exploited
R1262 T1736 T1732 prep of,phenomenon
R1263 T1735 T1734 punct -,known
R1264 T1738 T1732 punct ", ",phenomenon
R1265 T1739 T1740 dep which,concerns
R1266 T1737 T1736 pobj transgenes,of
R1267 T1741 T1742 amod heterogeneous,expression
R1268 T1740 T1732 relcl concerns,phenomenon
R1269 T1743 T1742 prep among,expression
R1270 T1742 T1740 dobj expression,concerns
R1271 T1745 T1743 pobj lines,among
R1272 T1744 T1745 amod different,lines
R1273 T1747 T1743 cc and,among
R1274 T1746 T1745 compound founder,lines
R1275 T1749 T1743 conj among,among
R1276 T1750 T1751 advmod genetically,identical
R1277 T1748 T1749 advmod even,among
R1278 T1752 T1749 pobj individuals,among
R1279 T1753 T1752 prep of,individuals
R1280 T1754 T1755 det a,line
R1281 T1755 T1753 pobj line,of
R1282 T1756 T1755 amod given,line
R1283 T1757 T1717 punct .,exploited
R1284 T1759 T1760 mark Although,is
R1285 T1760 T1766 advcl is,took
R1286 T1761 T1762 amod such,expression
R1287 T1762 T1760 nsubj expression,is
R1288 T1763 T1762 punct “,expression
R1289 T1764 T1762 nmod mosaic,expression
R1290 T1751 T1752 amod identical,individuals
R1291 T1767 T1760 advmod usually,is
R1292 T1768 T1760 acomp undesired,is
R1293 T1765 T1762 punct ”,expression
R1294 T1770 T1766 advmod here,took
R1295 T1771 T1766 nsubj we,took
R1296 T1769 T1766 punct ", ",took
R1297 T1773 T1772 prep of,advantage
R1298 T1774 T1773 pobj it,of
R1299 T1772 T1766 dobj advantage,took
R1300 T1776 T1775 pcomp ablating,by
R1301 T1775 T1766 prep by,took
R1302 T1778 T1776 dobj B,ablating
R1303 T1779 T1778 punct -,B
R1304 T1777 T1778 compound GluR,B
R1305 T1781 T1782 npadvmod gene,targeted
R1306 T1782 T1784 amod targeted,alleles
R1307 T1780 T1776 prep via,ablating
R1308 T1784 T1780 pobj alleles,via
R1309 T1785 T1784 punct ", ",alleles
R1310 T1783 T1782 punct -,targeted
R1311 T1787 T1788 compound GluR,B
R1312 T1788 T1784 compound B,alleles
R1313 T1786 T1784 amod floxed,alleles
R1314 T1790 T1776 prep with,ablating
R1315 T1791 T1792 det the,help
R1316 T1789 T1788 punct -,B
R1317 T1793 T1792 prep of,help
R1318 T1794 T1795 det a,line
R1319 T1792 T1790 pobj help,with
R1320 T1796 T1795 amod transgenic,line
R1321 T1795 T1793 pobj line,of
R1322 T1798 T1795 prep with,line
R1323 T1797 T1795 compound mouse,line
R1324 T1800 T1798 pobj expression,with
R1325 T1801 T1800 compound Cre,expression
R1326 T1799 T1800 amod variegated,expression
R1327 T1803 T1802 pobj forebrain,in
R1328 T1804 T1766 punct .,took
R1329 T1802 T1800 prep in,expression
R1330 T1806 T1807 prep By,investigated
R1331 T1808 T1806 pcomp correlating,By
R1332 T1810 T1812 compound B,levels
R1333 T1811 T1810 punct -,B
R1334 T1812 T1808 dobj levels,correlating
R1335 T1809 T1810 compound GluR,B
R1336 T1814 T1815 npadvmod olfaction,related
R1337 T1813 T1812 prep in,levels
R1338 T1816 T1815 punct -,related
R1339 T1815 T1817 amod related,regions
R1340 T1818 T1817 compound brain,regions
R1341 T1819 T1808 prep with,correlating
R1342 T1817 T1813 pobj regions,in
R1343 T1821 T1819 pobj data,with
R1344 T1822 T1821 amod behavioral,data
R1345 T1820 T1821 amod quantitative,data
R1346 T1824 T1807 nsubj we,investigated
R1347 T1825 T1826 det the,dependence
R1348 T1826 T1807 dobj dependence,investigated
R1349 T1823 T1807 punct ", ",investigated
R1350 T1828 T1829 compound GluR,B
R1351 T1829 T1827 pobj B,on
R1352 T1827 T1826 prep on,dependence
R1353 T1831 T1826 prep of,dependence
R1354 T1832 T1833 amod olfactory,discrimination
R1355 T1830 T1829 punct -,B
R1356 T1834 T1833 cc and,discrimination
R1357 T1835 T1833 conj memory,discrimination
R1358 T1833 T1831 pobj discrimination,of
R1359 T1838 T1839 advmod Moreover,used
R1360 T1836 T1807 punct .,investigated
R1361 T1840 T1839 punct ", ",used
R1362 T1842 T1839 advcl delineate,used
R1363 T1843 T1844 det the,areas
R1364 T1841 T1842 aux to,delineate
R1365 T1845 T1844 compound brain,areas
R1366 T1844 T1842 dobj areas,delineate
R1367 T1847 T1846 prep in,involved
R1368 T1848 T1849 det these,processes
R1369 T1849 T1847 pobj processes,in
R1370 T1846 T1844 acl involved,areas
R1371 T1851 T1849 amod olfactory,processes
R1372 T1852 T1839 nsubj we,used
R1373 T1850 T1849 amod distinctive,processes
R1374 T1854 T1839 dobj rescue,used
R1375 T1853 T1854 amod transgenic,rescue
R1376 T1856 T1854 prep of,rescue
R1377 T1857 T1858 compound GluR,B
R1378 T1855 T1854 punct ”,rescue
R1379 T1859 T1858 punct -,B
R1380 T1860 T1856 pobj ablation,of
R1381 T1861 T1854 punct ", ",rescue
R1382 T1858 T1860 compound B,ablation
R1383 T1863 T1854 prep in,rescue
R1384 T1864 T1865 amod piriform,cortex
R1385 T1862 T1863 advmod specifically,in
R1386 T1866 T1865 cc and,cortex
R1387 T1865 T1863 pobj cortex,in
R1388 T1868 T1839 punct .,used
R1389 T1871 T1872 nsubj efforts,allowed
R1390 T1867 T1865 conj hippocampus,cortex
R1391 T1874 T1872 ccomp dissect,allowed
R1392 T1870 T1871 det These,efforts
R1393 T1875 T1874 aux to,dissect
R1394 T1873 T1874 nsubj us,dissect
R1395 T1877 T1878 advmod both,spatially
R1396 T1878 T1874 advmod spatially,dissect
R1397 T1876 T1874 punct ", ",dissect
R1398 T1880 T1878 conj mechanistically,spatially
R1399 T1881 T1874 punct ", ",dissect
R1400 T1879 T1878 cc and,spatially
R1401 T1883 T1874 dobj role,dissect
R1402 T1882 T1883 det the,role
R1403 T1885 T1886 compound GluR,B
R1404 T1886 T1888 npadvmod B,mediated
R1405 T1884 T1883 prep of,role
R1406 T1888 T1890 amod mediated,properties
R1407 T1889 T1888 punct -,mediated
R1408 T1887 T1886 punct -,B
R1409 T1891 T1890 compound AMPAR,properties
R1410 T1890 T1884 pobj properties,of
R1411 T1893 T1894 amod selected,regions
R1412 T1894 T1892 pobj regions,in
R1413 T1892 T1883 prep in,role
R1414 T1896 T1883 prep in,role
R1415 T1897 T1898 compound odor,learning
R1416 T1895 T1894 compound brain,regions
R1417 T1899 T1898 punct ", ",learning
R1418 T1898 T1896 pobj learning,in
R1419 T1901 T1900 punct ", ",discrimination
R1420 T1902 T1900 cc and,discrimination
R1421 T1900 T1898 conj discrimination,learning
R1422 T1904 T1872 punct .,allowed
R1423 T1903 T1900 conj memory,discrimination
R228 T654 T965 punct ),cells
R229 T655 T656 det The,sense
R230 T656 T657 nsubj sense,is
R231 T658 T656 prep of,sense
R232 T659 T658 pobj smell,of
R233 T660 T657 prep of,is
R234 T661 T662 amod paramount,importance
R235 T662 T660 pobj importance,of
R236 T663 T662 prep for,importance
R237 T664 T663 pobj rodents,for
R238 T665 T666 punct [,1
R239 T666 T664 parataxis 1,rodents
R240 T667 T666 punct ],1
R241 T668 T664 punct ", ",rodents
R242 T669 T670 prep for,permits
R243 T670 T664 relcl permits,rodents
R244 T671 T669 pobj which,for
R245 T672 T673 amod rapid,discrimination
R246 T673 T670 nsubj discrimination,permits
R247 T674 T673 compound odor,discrimination
R248 T675 T673 cc and,discrimination
R249 T676 T677 advmod long,lasting
R250 T677 T679 amod lasting,memory
R251 T678 T677 punct -,lasting
R252 T679 T673 conj memory,discrimination
R253 T680 T679 amod olfactory,memory
R254 T681 T670 dobj responses,permits
R255 T682 T681 prep to,responses
R256 T683 T682 pobj predator,to
R257 T684 T683 cc and,predator
R258 T685 T683 conj prey,predator
R259 T686 T681 amod critical,responses
R260 T687 T686 prep for,critical
R261 T688 T687 pobj survival,for
R262 T689 T657 punct .,is
R263 T691 T692 advmod Consequently,are
R264 T693 T692 punct ", ",are
R265 T694 T695 det the,analyses
R266 T695 T692 nsubj analyses,are
R267 T696 T695 amod behavioral,analyses
R268 T697 T695 prep of,analyses
R269 T698 T699 amod olfactory,capabilities
R270 T699 T697 pobj capabilities,of
R271 T700 T699 prep in,capabilities
R272 T701 T700 pobj rodents,in
R273 T702 T692 acomp efficient,are
R274 T703 T702 punct ", ",efficient
R275 T704 T702 conj quantitative,efficient
R276 T705 T704 punct ", ",quantitative
R277 T706 T704 cc and,quantitative
R278 T707 T704 conj reproducible,quantitative
R279 T708 T709 punct [,2
R280 T709 T692 parataxis 2,are
R281 T710 T711 punct –,4
R282 T711 T709 prep 4,2
R283 T712 T709 punct ],2
R284 T713 T692 punct .,are
R285 T715 T716 mark While,implicated
R286 T716 T750 advcl implicated,delineated
R287 T717 T716 prep in,implicated
R288 T718 T719 det the,formation
R289 T719 T717 pobj formation,in
R290 T720 T719 cc and,formation
R291 T721 T719 conj storage,formation
R292 T722 T719 prep of,formation
R293 T723 T724 amod olfactory,memory
R294 T724 T722 pobj memory,of
R295 T725 T726 amod piriform,cortex
R296 T726 T716 nsubjpass cortex,implicated
R297 T727 T728 punct [,5
R298 T728 T726 parataxis 5,cortex
R299 T729 T730 punct –,7
R300 T730 T728 prep 7,5
R301 T731 T728 punct ],5
R302 T732 T726 punct ", ",cortex
R303 T733 T726 conj hippocampus,cortex
R304 T734 T735 punct [,9
R305 T735 T733 parataxis 9,hippocampus
R306 T736 T735 nummod 8,9
R307 T737 T735 punct ",",9
R308 T738 T735 punct ],9
R309 T739 T733 punct ", ",hippocampus
R310 T740 T733 cc and,hippocampus
R311 T741 T742 amod olfactory,bulb
R312 T742 T733 conj bulb,hippocampus
R313 T743 T744 punct [,10
R314 T744 T742 parataxis 10,bulb
R315 T745 T746 punct –,12
R316 T746 T744 prep 12,10
R317 T747 T744 punct ],10
R318 T748 T716 auxpass are,implicated
R319 T749 T716 advmod all,implicated
R320 T751 T750 punct ", ",delineated
R321 T752 T753 det the,correlates
R322 T753 T750 nsubjpass correlates,delineated
R323 T754 T753 amod cellular,correlates
R324 T755 T753 prep for,correlates
R325 T756 T757 det these,processes
R326 T757 T755 pobj processes,for
R327 T758 T750 aux have,delineated
R328 T759 T750 neg not,delineated
R329 T760 T750 auxpass been,delineated
R330 T761 T750 advmod clearly,delineated
R331 T762 T750 punct .,delineated
R332 T764 T765 det The,contribution
R333 T765 T766 nsubj contribution,is
R334 T767 T765 prep of,contribution
R335 T768 T769 det the,hippocampus
R336 T769 T767 pobj hippocampus,of
R337 T770 T765 prep to,contribution
R338 T771 T772 amod olfactory,memory
R339 T772 T770 pobj memory,to
R340 T773 T766 advmod presently,is
R341 T774 T766 acomp controversial,is
R342 T775 T776 punct [,2
R343 T776 T766 parataxis 2,is
R344 T777 T776 punct ",",2
R345 T778 T776 appos 13,2
R346 T779 T780 punct –,18
R347 T780 T778 prep 18,13
R348 T781 T776 punct ],2
R349 T782 T766 punct ", ",is
R350 T783 T766 cc but,is
R351 T784 T785 auxpass is,deemed
R352 T785 T766 conj deemed,is
R353 T786 T785 oprd unlikely,deemed
R354 T787 T786 prep for,unlikely
R355 T788 T789 amod simple,tasks
R356 T789 T787 pobj tasks,for
R357 T790 T791 amod olfactory,discrimination
R358 T791 T789 compound discrimination,tasks
R359 T792 T793 punct [,19
R360 T793 T785 parataxis 19,deemed
R361 T794 T793 nummod 9,19
R362 T795 T793 punct ",",19
R363 T796 T793 punct ],19
R364 T797 T766 punct .,is
R365 T799 T800 prep In,appear
R366 T801 T799 pobj fact,In
R367 T802 T800 punct ", ",appear
R368 T803 T804 det the,candidates
R369 T804 T800 nsubj candidates,appear
R370 T805 T806 advmod most,likely
R371 T806 T804 amod likely,candidates
R372 T807 T804 prep for,candidates
R373 T808 T809 det a,correlate
R374 T809 T807 pobj correlate,for
R375 T810 T809 amod cellular,correlate
R376 T811 T809 prep of,correlate
R377 T812 T813 amod olfactory,memory
R378 T813 T811 pobj memory,of
R379 T814 T815 aux to,be
R380 T815 T800 xcomp be,appear
R381 T816 T817 det the,connections
R382 T817 T815 attr connections,be
R383 T818 T817 amod neuronal,connections
R384 T819 T817 prep in,connections
R385 T820 T821 det the,cortex
R386 T821 T819 pobj cortex,in
R387 T822 T821 amod piriform,cortex
R388 T823 T800 prep due,appear
R389 T824 T823 pcomp to,due
R390 T825 T826 det the,connectivity
R391 T826 T823 pobj connectivity,due
R392 T827 T826 amod associational,connectivity
R393 T828 T829 punct [,5
R394 T829 T826 parataxis 5,connectivity
R395 T830 T829 punct ],5
R396 T831 T826 cc and,connectivity
R397 T832 T833 det the,expression
R398 T833 T826 conj expression,connectivity
R399 T834 T833 prep of,expression
R400 T835 T836 amod several,forms
R401 T836 T834 pobj forms,of
R402 T837 T836 prep of,forms
R403 T838 T839 amod cellular,plasticity
R404 T839 T837 pobj plasticity,of
R405 T840 T838 cc and,cellular
R406 T841 T838 conj synaptic,cellular
R407 T842 T843 punct [,7
R408 T843 T800 parataxis 7,appear
R409 T844 T843 punct ",",7
R410 T845 T843 appos 20,7
R411 T846 T847 punct –,23
R412 T847 T845 prep 23,20
R413 T848 T843 punct ],7
R414 T849 T800 punct .,appear
R415 T851 T852 prep Concerning,attributed
R416 T853 T854 compound odor,discrimination
R417 T854 T851 pobj discrimination,Concerning
R418 T855 T854 appos itself,discrimination
R419 T856 T852 punct ", ",attributed
R420 T857 T858 amod cellular,mechanisms
R421 T858 T852 nsubjpass mechanisms,attributed
R422 T859 T858 prep for,mechanisms
R423 T860 T861 det this,process
R424 T861 T859 pobj process,for
R425 T862 T852 auxpass are,attributed
R426 T863 T852 advmod often,attributed
R427 T864 T852 prep to,attributed
R428 T865 T866 det the,circuitry
R429 T866 T864 pobj circuitry,to
R430 T867 T866 amod inhibitory,circuitry
R431 T868 T866 prep of,circuitry
R432 T869 T870 det the,bulb
R433 T870 T868 pobj bulb,of
R434 T871 T870 amod olfactory,bulb
R435 T872 T873 punct (,reviewed
R436 T873 T852 parataxis reviewed,attributed
R437 T874 T875 punct [,24
R438 T875 T873 parataxis 24,reviewed
R439 T876 T877 punct –,30
R440 T877 T875 prep 30,24
R441 T878 T875 punct ],24
R442 T879 T873 punct ;,reviewed
R443 T880 T873 prep in,reviewed
R444 T881 T880 punct [,in
R445 T882 T880 pobj 31,in
R446 T883 T884 punct –,33
R447 T884 T882 prep 33,31
R448 T885 T873 punct ],reviewed
R449 T886 T873 punct ),reviewed
R450 T887 T852 punct .,attributed
R451 T889 T890 amod Lateral,circuits
R452 T890 T892 nsubjpass circuits,postulated
R453 T891 T890 amod inhibitory,circuits
R454 T893 T892 auxpass were,postulated
R455 T894 T892 punct ", ",postulated
R456 T895 T892 prep in,postulated
R457 T896 T895 pobj analogy,in
R458 T897 T896 prep to,analogy
R459 T898 T897 pobj retina,to
R460 T899 T900 punct [,35
R461 T900 T892 parataxis 35,postulated
R462 T901 T900 nummod 34,35
R463 T902 T900 punct ",",35
R464 T903 T900 punct ],35
R465 T904 T892 punct ", ",postulated
R466 T905 T906 aux to,mediate
R467 T906 T892 advcl mediate,postulated
R468 T907 T908 compound contrast,enhancement
R469 T908 T906 dobj enhancement,mediate
R470 T909 T910 punct [,24
R471 T910 T908 parataxis 24,enhancement
R472 T911 T910 punct ],24
R473 T912 T908 punct ", ",enhancement
R474 T913 T914 prep for,provide
R475 T914 T908 relcl provide,enhancement
R476 T915 T913 pobj which,for
R477 T916 T917 amod physiological,recordings
R478 T917 T914 nsubj recordings,provide
R479 T918 T919 punct [,37
R480 T919 T917 parataxis 37,recordings
R481 T920 T919 nummod 24,37
R482 T921 T919 punct ",",37
R483 T922 T919 nummod 36,37
R484 T923 T919 punct ",",37
R485 T924 T919 punct ],37
R486 T925 T917 cc and,recordings
R487 T926 T927 compound modeling,data
R488 T927 T917 conj data,recordings
R489 T928 T927 punct ", ",data
R490 T929 T927 prep based,data
R491 T930 T929 prep on,based
R492 T931 T932 det the,anatomy
R493 T932 T930 pobj anatomy,on
R494 T933 T934 advmod well,known
R495 T934 T932 amod known,anatomy
R496 T935 T934 punct -,known
R497 T936 T937 punct [,29
R498 T937 T927 parataxis 29,data
R499 T938 T937 punct ],29
R500 T939 T914 punct ", ",provide
R501 T940 T941 amod additional,support
R502 T941 T914 dobj support,provide
R503 T942 T892 punct .,postulated
R504 T944 T945 amod Such,enhancement
R505 T945 T947 nsubj enhancement,rest
R506 T946 T945 compound contrast,enhancement
R507 T948 T947 aux may,rest
R508 T949 T947 prep in,rest
R509 T950 T951 amod large,part
R510 T951 T949 pobj part,in
R511 T952 T947 prep on,rest
R512 T953 T954 det the,properties
R513 T954 T952 pobj properties,on
R514 T955 T954 amod particular,properties
R515 T956 T954 prep of,properties
R516 T957 T958 amod dendrodendritic,synapses
R517 T958 T956 pobj synapses,of
R518 T959 T958 prep between,synapses
R519 T960 T961 det the,neurons
R520 T961 T959 pobj neurons,between
R521 T962 T961 amod principal,neurons
R522 T963 T961 compound output,neurons
R523 T964 T965 punct (,cells
R524 T965 T961 parataxis cells,neurons
R525 T966 T965 amod mitral,cells
R526 T967 T961 cc and,neurons
R527 T968 T969 amod local,neurons
R528 T969 T961 conj neurons,neurons
R529 T970 T969 amod inhibitory,neurons
R530 T971 T972 punct (,cells
R531 T972 T969 parataxis cells,neurons
R532 T973 T972 compound granule,cells
R533 T974 T972 punct ),cells
R534 T975 T961 prep of,neurons
R535 T976 T977 det the,bulb
R536 T977 T975 pobj bulb,of
R537 T978 T977 amod olfactory,bulb
R538 T979 T947 punct .,rest
R539 T981 T982 prep In,controlled
R540 T983 T984 det these,synapses
R541 T984 T981 pobj synapses,In
R542 T985 T984 amod distinct,synapses
R543 T986 T982 punct ", ",controlled
R544 T987 T988 amod lateral,inhibition
R545 T988 T982 nsubjpass inhibition,controlled
R546 T989 T987 cc and,lateral
R547 T990 T987 conj recurrent,lateral
R548 T991 T988 acl mediated,inhibition
R549 T992 T991 agent by,mediated
R550 T993 T994 det the,system
R551 T994 T992 pobj system,by
R552 T995 T996 npadvmod gamma,aminobutyric
R553 T996 T994 amod aminobutyric,system
R554 T997 T996 punct -,aminobutyric
R555 T998 T999 compound acid,A
R556 T999 T994 compound A,system
R557 T1000 T999 punct -,A
R558 T1001 T982 aux may,controlled
R559 T1002 T982 auxpass be,controlled
R560 T1003 T982 agent by,controlled
R561 T1004 T1005 det the,activity
R562 T1005 T1003 pobj activity,by
R563 T1006 T1005 prep of,activity
R564 T1007 T1008 det the,part
R565 T1008 T1006 pobj part,of
R566 T1009 T1010 advmod closely,appositioned
R567 T1010 T1008 amod appositioned,part
R568 T1011 T1008 amod glutamatergic,part
R569 T1012 T982 punct ", ",controlled
R570 T1013 T1014 advmod perhaps,triggering
R571 T1014 T982 advcl triggering,controlled
R572 T1015 T1016 amod increased,release
R573 T1016 T1014 dobj release,triggering
R574 T1017 T1018 npadvmod gamma,aminobutyric
R575 T1018 T1020 amod aminobutyric,acid
R576 T1019 T1018 punct -,aminobutyric
R577 T1020 T1016 compound acid,release
R578 T1021 T1016 prep by,release
R579 T1022 T1023 nmod Ca2,influx
R580 T1023 T1021 pobj influx,by
R581 T1024 T1022 punct +,Ca2
R582 T1025 T1023 prep through,influx
R583 T1026 T1027 npadvmod glutamate,gated
R584 T1027 T1029 amod gated,channels
R585 T1028 T1027 punct -,gated
R586 T1029 T1025 pobj channels,through
R587 T1030 T1029 compound receptor,channels
R588 T1031 T1032 punct (,38
R589 T1032 T982 parataxis 38,controlled
R590 T1033 T1032 punct [,38
R591 T1034 T1032 punct ],38
R592 T1035 T1032 punct ;,38
R593 T1036 T1032 advcl see,38
R594 T1037 T1036 advmod also,see
R595 T1038 T1036 punct [,see
R596 T1039 T1036 dobj 39,see
R597 T1040 T1032 punct ],38
R598 T1041 T1032 punct ),38
R599 T1042 T982 punct .,controlled
R600 T1044 T1045 prep Given,sought
R601 T1046 T1047 mark that,rely
R602 T1047 T1044 pcomp rely,Given
R603 T1048 T1049 amod neuronal,circuits
R604 T1049 T1047 nsubj circuits,rely
R605 T1050 T1049 acl underlying,circuits
R606 T1051 T1052 compound odor,discrimination
R607 T1052 T1050 dobj discrimination,underlying
R608 T1053 T1052 punct ", ",discrimination
R609 T1054 T1055 advmod as,as
R610 T1055 T1052 cc as,discrimination
R611 T1056 T1055 advmod well,as
R612 T1057 T1058 amod olfactory,memory
R613 T1058 T1052 conj memory,discrimination
R614 T1059 T1047 punct ", ",rely
R615 T1060 T1047 prep on,rely
R616 T1061 T1060 pobj properties,on
R617 T1062 T1061 prep of,properties
R618 T1063 T1064 amod fast,neurotransmission
R619 T1064 T1062 pobj neurotransmission,of
R620 T1065 T1064 amod excitatory,neurotransmission
R621 T1066 T1064 acl mediated,neurotransmission
R622 T1067 T1066 agent by,mediated
R623 T1068 T1069 nmod α,amino
R624 T1069 T1071 nmod amino,isoxazolepropionate
R625 T1070 T1069 punct -,amino
R626 T1071 T1083 compound isoxazolepropionate,receptors
R627 T1072 T1071 punct -,isoxazolepropionate
R628 T1073 T1074 nummod 3,hydroxy
R629 T1074 T1071 nmod hydroxy,isoxazolepropionate
R630 T1075 T1074 punct -,hydroxy
R631 T1076 T1071 punct -,isoxazolepropionate
R632 T1077 T1078 nummod 5,methyl
R633 T1078 T1071 nmod methyl,isoxazolepropionate
R634 T1079 T1078 punct -,methyl
R635 T1080 T1071 punct -,isoxazolepropionate
R636 T1081 T1071 nummod 4,isoxazolepropionate
R637 T1082 T1071 punct -,isoxazolepropionate
R638 T1083 T1067 pobj receptors,by
R639 T1084 T1083 punct (,receptors
R640 T1085 T1083 appos AMPARs,receptors
R641 T1086 T1045 punct ),sought
R642 T1087 T1045 punct ", ",sought
R643 T1088 T1045 nsubj we,sought
R644 T1089 T1090 aux to,alter
R645 T1090 T1045 xcomp alter,sought
R646 T1091 T1090 punct ", ",alter
R647 T1092 T1090 prep by,alter
R648 T1093 T1094 amod genetic,means
R649 T1094 T1092 pobj means,by
R650 T1095 T1090 punct ", ",alter
R651 T1096 T1097 det the,contribution
R652 T1097 T1090 dobj contribution,alter
R653 T1098 T1097 amod specific,contribution
R654 T1099 T1097 amod functional,contribution
R655 T1100 T1097 prep of,contribution
R656 T1101 T1102 nmod α,amino
R657 T1102 T1104 nmod amino,isoxazolepropionate
R658 T1103 T1102 punct -,amino
R659 T1104 T1116 nmod isoxazolepropionate,channels
R660 T1105 T1104 punct -,isoxazolepropionate
R661 T1106 T1107 nummod 3,hydroxy
R662 T1107 T1104 nmod hydroxy,isoxazolepropionate
R663 T1108 T1107 punct -,hydroxy
R664 T1109 T1104 punct -,isoxazolepropionate
R665 T1110 T1111 nummod 5,methyl
R666 T1111 T1104 nmod methyl,isoxazolepropionate
R667 T1112 T1111 punct -,methyl
R668 T1113 T1104 punct -,isoxazolepropionate
R669 T1114 T1104 nummod 4,isoxazolepropionate
R670 T1115 T1104 punct -,isoxazolepropionate
R671 T1116 T1100 pobj channels,of
R672 T1117 T1104 punct (,isoxazolepropionate
R673 T1118 T1104 appos AMPA,isoxazolepropionate
R674 T1119 T1116 punct ),channels
R675 T1120 T1116 acl containing,channels
R676 T1121 T1122 det the,subunit
R677 T1122 T1120 dobj subunit,containing
R678 T1123 T1122 amod dominant,subunit
R679 T1124 T1125 compound GluR,B
R680 T1125 T1122 appos B,subunit
R681 T1126 T1125 punct -,B
R682 T1127 T1045 punct .,sought
R683 T1129 T1130 prep Of,contained
R684 T1131 T1132 det the,constituents
R685 T1132 T1129 pobj constituents,Of
R686 T1133 T1132 nummod four,constituents
R687 T1134 T1132 compound AMPAR,constituents
R688 T1135 T1132 punct ", ",constituents
R689 T1136 T1137 compound GluR,A
R690 T1137 T1132 appos A,constituents
R691 T1138 T1137 punct -,A
R692 T1139 T1137 prep to,A
R693 T1140 T1139 pobj D,to
R694 T1141 T1137 punct (,A
R695 T1142 T1137 appos GluR1,A
R696 T1143 T1142 prep to,GluR1
R697 T1144 T1143 pobj 4,to
R698 T1145 T1137 punct ),A
R699 T1146 T1137 punct ", ",A
R700 T1147 T1148 dep which,form
R701 T1148 T1137 relcl form,A
R702 T1150 T1148 dobj channels,form
R703 T1151 T1150 prep with,channels
R704 T1152 T1153 amod different,combinations
R705 T1153 T1151 pobj combinations,with
R706 T1154 T1153 amod binary,combinations
R707 T1155 T1153 compound subunit,combinations
R708 T1156 T1130 punct ", ",contained
R709 T1157 T1158 compound GluR,B
R710 T1158 T1130 nsubjpass B,contained
R711 T1159 T1158 punct -,B
R712 T1160 T1130 auxpass is,contained
R713 T1161 T1130 prep in,contained
R714 T1162 T1163 det the,majority
R715 T1149 T1150 amod tetrameric,channels
R716 T1164 T1163 prep of,majority
R717 T1165 T1164 pobj AMPARs,of
R718 T1166 T1130 punct .,contained
R719 T1163 T1161 pobj majority,in
R720 T1168 T1169 compound GluR,B
R721 T1169 T1171 nsubjpass B,involved
R722 T1172 T1171 auxpass is,involved
R723 T1170 T1169 punct -,B
R724 T1174 T1171 prep in,involved
R725 T1175 T1176 det the,formation
R726 T1176 T1174 pobj formation,in
R727 T1177 T1176 cc and,formation
R728 T1178 T1176 conj trafficking,formation
R729 T1173 T1171 advmod critically,involved
R730 T1180 T1179 pobj AMPARs,of
R731 T1181 T1171 punct ", ",involved
R732 T1179 T1176 prep of,formation
R733 T1183 T1171 conj dominates,involved
R734 T1184 T1185 poss their,conductance
R735 T1185 T1183 dobj conductance,dominates
R736 T1186 T1185 compound ion,conductance
R737 T1182 T1171 cc and,involved
R738 T1188 T1189 compound gating,properties
R739 T1189 T1185 conj properties,conductance
R740 T1187 T1185 cc and,conductance
R741 T1191 T1183 parataxis 40,dominates
R742 T1192 T1193 punct –,46
R743 T1190 T1191 punct [,40
R744 T1194 T1191 punct ],40
R745 T1195 T1171 punct .,involved
R746 T1193 T1191 prep 46,40
R747 T1197 T1198 advmod Notably,mediated
R748 T1199 T1198 punct ", ",mediated
R749 T1201 T1198 nsubjpass permeability,mediated
R750 T1200 T1201 det the,permeability
R751 T1203 T1201 amod low,permeability
R752 T1204 T1201 nmod Ca2,permeability
R753 T1202 T1203 advmod normally,low
R754 T1206 T1201 prep of,permeability
R755 T1207 T1208 compound AMPA,channels
R756 T1205 T1204 punct +,Ca2
R757 T1209 T1236 amod critical,site
R758 T1210 T1201 prep in,permeability
R759 T1211 T1380 prep of,ablation
R760 T1208 T1206 pobj channels,of
R761 T1214 T1210 pobj neurons,in
R762 T1215 T1198 auxpass is,mediated
R763 T1212 T1214 amod principal,neurons
R764 T1216 T1198 advmod solely,mediated
R765 T1217 T1198 agent by,mediated
R766 T1218 T1643 nummod 55,57
R767 T1213 T1444 amod synaptic,plasticity
R768 T1220 T1217 pobj B,by
R769 T1221 T1220 punct -,B
R770 T1219 T1220 compound GluR,B
R771 T1223 T1717 punct ", ",exploited
R772 T1225 T1224 pcomp to,due
R773 T1222 T1198 punct ", ",mediated
R774 T1227 T1228 det a,residue
R775 T1224 T1198 prep due,mediated
R776 T1228 T1224 pobj residue,due
R777 T1226 T1854 punct “,rescue
R778 T1230 T1228 compound arginine,residue
R779 T1231 T1232 punct (,R587
R780 T1229 T1228 amod unique,residue
R781 T1233 T1232 punct ),R587
R782 T1234 T1228 prep in,residue
R783 T1235 T1236 det the,site
R784 T1232 T1228 parataxis R587,residue
R785 T1237 T1209 advmod functionally,critical
R786 T1239 T1236 nmod arginine,site
R787 T1236 T1234 pobj site,in
R788 T1238 T1239 nmod glutamine,arginine
R789 T1241 T1242 punct (,R
R790 T1242 T1236 parataxis R,site
R791 T1240 T1239 punct /,arginine
R792 T1244 T1242 punct /,R
R793 T1245 T1242 punct ),R
R794 T1243 T1242 compound Q,R
R795 T1247 T1248 det the,M2
R796 T1248 T1246 pobj M2,of
R797 T1246 T1236 prep of,site
R798 T1250 T1248 amod forming,M2
R799 T1249 T1250 npadvmod pore,forming
R800 T1252 T1248 compound segment,M2
R801 T1251 T1250 punct -,forming
R802 T1254 T1236 parataxis 48,site
R803 T1253 T1254 punct [,48
R804 T1256 T1254 punct ",",48
R805 T1257 T1254 nummod 47,48
R806 T1255 T1254 nummod 44,48
R807 T1259 T1254 punct ],48
R808 T1260 T1228 punct ", ",residue
R809 T1258 T1254 punct ",",48
R810 T1262 T1261 prep from,resulting
R811 T1263 T1264 compound RNA,editing
R812 T1264 T1262 pobj editing,from
R813 T1261 T1228 acl resulting,residue
R814 T1266 T1267 compound GluR,B
R815 T1267 T1269 compound B,pre-mRNA
R816 T1265 T1264 prep of,editing
R817 T1269 T1265 pobj pre-mRNA,of
R818 T1270 T1271 punct (,49
R819 T1268 T1267 punct -,B
R820 T1272 T1271 punct [,49
R821 T1273 T1271 punct ],49
R822 T1271 T1198 parataxis 49,mediated
R823 T1275 T1271 advcl reviewed,49
R824 T1276 T1275 prep in,reviewed
R825 T1274 T1271 punct ;,49
R826 T1278 T1276 pobj 50,in
R827 T1279 T1271 punct ],49
R828 T1280 T1271 punct ),49
R829 T1281 T1198 punct .,mediated
R830 T1277 T1276 punct [,in
R831 T1283 T1284 advmod Hence,leads
R832 T1286 T1287 preconj either,deficiency
R833 T1287 T1284 nsubj deficiency,leads
R834 T1285 T1284 punct ", ",leads
R835 T1289 T1287 compound B,deficiency
R836 T1290 T1289 punct -,B
R837 T1288 T1289 compound GluR,B
R838 T1292 T1287 cc or,deficiency
R839 T1293 T1294 det the,expression
R840 T1291 T1287 punct ", ",deficiency
R841 T1295 T1294 prep of,expression
R842 T1296 T1297 nmod Q,R
R843 T1294 T1287 conj expression,deficiency
R844 T1298 T1297 punct /,R
R845 T1299 T1295 pobj B,of
R846 T1297 T1299 nmod R,B
R847 T1301 T1299 amod unedited,B
R848 T1303 T1299 compound GluR,B
R849 T1300 T1301 npadvmod site,unedited
R850 T1302 T1301 punct -,unedited
R851 T1305 T1299 prep with,B
R852 T1306 T1307 det a,residue
R853 T1304 T1299 punct -,B
R854 T1308 T1307 compound glutamine,residue
R855 T1309 T1307 prep at,residue
R856 T1307 T1305 pobj residue,with
R857 T1311 T1309 pobj site,at
R858 T1310 T1311 det the,site
R859 T1313 T1311 compound channel,site
R860 T1314 T1284 punct ", ",leads
R861 T1312 T1311 amod critical,site
R862 T1316 T1317 amod increased,permeability
R863 T1317 T1315 pobj permeability,to
R864 T1315 T1284 prep to,leads
R865 T1319 T1318 punct +,Ca2
R866 T1320 T1317 prep of,permeability
R867 T1318 T1317 nmod Ca2,permeability
R868 T1322 T1320 pobj channels,of
R869 T1323 T1284 punct ", ",leads
R870 T1321 T1322 compound AMPA,channels
R871 T1325 T1284 advcl demonstrated,leads
R872 T1326 T1325 advmod amply,demonstrated
R873 T1324 T1325 mark as,demonstrated
R874 T1328 T1329 npadvmod gene,targeted
R875 T1329 T1331 amod targeted,mice
R876 T1327 T1325 prep in,demonstrated
R877 T1331 T1327 pobj mice,in
R878 T1332 T1333 punct [,60
R879 T1330 T1329 punct -,targeted
R880 T1334 T1333 nummod 51,60
R881 T1335 T1333 punct ",",60
R882 T1333 T1284 parataxis 60,leads
R883 T1337 T1333 punct ",",60
R884 T1336 T1333 nummod 53,60
R885 T1339 T1333 punct ",",60
R886 T1340 T1333 punct ],60
R887 T1338 T1333 nummod 58,60
R888 T1343 T1344 advmod Thus,generate
R889 T1341 T1284 punct .,leads
R890 T1345 T1344 punct ", ",generate
R891 T1347 T1344 nsubj absence,generate
R892 T1348 T1347 prep of,absence
R893 T1346 T1347 det the,absence
R894 T1350 T1348 pobj B,of
R895 T1351 T1350 punct -,B
R896 T1349 T1350 compound GluR,B
R897 T1353 T1347 cc or,absence
R898 T1354 T1355 det the,expression
R899 T1352 T1347 punct ", ",absence
R900 T1356 T1355 prep of,expression
R901 T1357 T1358 nmod GluR,Q
R902 T1358 T1356 pobj Q,of
R903 T1355 T1347 conj expression,absence
R904 T1360 T1358 nmod B,Q
R905 T1361 T1358 punct (,Q
R906 T1359 T1358 punct -,Q
R907 T1363 T1347 prep in,absence
R908 T1362 T1358 punct ),Q
R909 T1365 T1363 pobj bulb,in
R910 T1364 T1365 det the,bulb
R911 T1367 T1344 punct ", ",generate
R912 T1368 T1344 aux may,generate
R913 T1366 T1365 amod olfactory,bulb
R914 T1370 T1344 dobj inhibition,generate
R915 T1371 T1344 prep in,generate
R916 T1369 T1370 amod increased,inhibition
R917 T1373 T1371 pobj cells,in
R918 T1374 T1344 punct .,generate
R919 T1372 T1373 amod mitral,cells
R920 T1376 T1377 advmod Moreover,alter
R921 T1378 T1377 punct ", ",alter
R922 T1379 T1380 det the,ablation
R923 T1381 T1382 compound GluR,B
R924 T1382 T1211 pobj B,of
R925 T1380 T1377 nsubj ablation,alter
R926 T1384 T1380 punct ", ",ablation
R927 T1385 T1380 cc but,ablation
R928 T1383 T1382 punct -,B
R929 T1387 T1380 conj changes,ablation
R930 T1388 T1387 prep in,changes
R931 T1386 T1385 advmod also,but
R932 T1390 T1388 pobj extent,in
R933 T1391 T1390 prep of,extent
R934 T1389 T1390 det the,extent
R935 T1393 T1395 compound R,editing
R936 T1394 T1393 punct /,R
R937 T1392 T1393 compound Q,R
R938 T1396 T1395 compound site,editing
R939 T1397 T1395 prep of,editing
R940 T1395 T1391 pobj editing,of
R941 T1399 T1397 pobj B,of
R942 T1398 T1399 compound GluR,B
R943 T1401 T1377 punct ", ",alter
R944 T1402 T1377 aux can,alter
R945 T1400 T1399 punct -,B
R946 T1404 T1377 dobj strength,alter
R947 T1405 T1404 prep of,strength
R948 T1403 T1404 det the,strength
R949 T1407 T1405 pobj transmission,of
R950 T1408 T1407 amod synaptic,transmission
R951 T1406 T1407 amod excitatory,transmission
R952 T1410 T1411 det the,populations
R953 T1409 T1377 prep in,alter
R954 T1412 T1413 advmod genetically,addressed
R955 T1413 T1411 amod addressed,populations
R956 T1411 T1409 pobj populations,in
R957 T1415 T1416 punct [,60
R958 T1414 T1411 amod neuronal,populations
R959 T1417 T1416 nummod 51,60
R960 T1418 T1416 punct ",",60
R961 T1416 T1377 parataxis 60,alter
R962 T1420 T1416 punct ",",60
R963 T1421 T1416 punct ],60
R964 T1419 T1416 nummod 58,60
R965 T1423 T1424 advmod thus,shifting
R966 T1422 T1377 punct ", ",alter
R967 T1425 T1424 advmod potentially,shifting
R968 T1426 T1427 det the,balance
R969 T1424 T1377 advcl shifting,alter
R970 T1428 T1427 prep of,balance
R971 T1429 T1430 amod excitatory,transmission
R972 T1427 T1424 dobj balance,shifting
R973 T1431 T1429 cc and,excitatory
R974 T1432 T1429 conj inhibitory,excitatory
R975 T1430 T1428 pobj transmission,of
R976 T1434 T1435 det the,circuits
R977 T1435 T1433 pobj circuits,in
R978 T1433 T1424 prep in,shifting
R979 T1437 T1377 punct .,alter
R980 T1436 T1435 amod affected,circuits
R981 T1439 T1440 advmod Similarly,alter
R982 T1442 T1440 nsubj changes,alter
R983 T1443 T1442 prep in,changes
R984 T1441 T1440 punct ", ",alter
R985 T1445 T1442 prep due,changes
R986 T1444 T1443 pobj plasticity,in
R987 T1447 T1448 npadvmod Ca2,permeable
R988 T1448 T1451 amod permeable,AMPARs
R989 T1446 T1445 pcomp to,due
R990 T1450 T1448 punct -,permeable
R991 T1451 T1445 pobj AMPARs,due
R992 T1449 T1447 punct +,Ca2
R993 T1453 T1451 parataxis 60,AMPARs
R994 T1452 T1453 punct [,60
R995 T1455 T1453 punct ",",60
R996 T1454 T1453 nummod 51,60
R997 T1457 T1453 punct ",",60
R998 T1458 T1453 punct ],60
R999 T1456 T1453 nummod 52,60