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PMC:1255741 / 15682-17297 JSONTXT 4 Projects

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Id Subject Object Predicate Lexical cue
T4143 0-1615 sentence denotes Figure 2 Odor Learning and Discrimination Is Enhanced, but Odor Memory Is Reduced in GluR-BΔFB Mice (A) Schematic diagram depicting Cre-mediated ablation of loxP-flanked exon 11 of the GluR-B alleles. (B and C) Nine GluR-BΔFB (red) and nine GluRB2lox littermate controls (black) were trained for successive odor discrimination tasks on 1% AA versus 1% EB (400 trials), 0.4% Cin/0.6% Eu versus 0.6% Cin/0.4% Eu (400 trials) and 1% Pel versus 1% Val. GluR-BΔFB mice showed increased learning/discrimination compared with controls, both using the performance as measured by percentage of correct trials ([B]; group effect: F1,16 = 6.55, p < 0.05) or the discrimination index (C), that is the maximal difference of the sampling pattern (see Materials and Methods and Figure 1D–1F; F1,16 = 29.5, p < 10−4). (D) Sampling difference for the last 100 trials of the mixture discrimination task (indicated with a black arrow in [C]) for all 18 individual mice. Note that the GluR-BΔFB mice show a consistently larger sampling difference. (E) Olfactory memory performance for nine littermate controls (black) and nine GluR-BΔFB (red) mice. Olfactory memory was tested at the time indicated by the black bar in (C) by interleaving the Pel and Val trials with unrewarded AA and EB trials. AA, amylacetate; Cin, cineol; EB, ethylbutyrate; Eu, eugenol; Pel, pelargonic acid; Val, valeric acid. If the GluR-B/GluR-B(Q) switch-induced alterations in the Ca2+ permeability of the AMPA channels are linked to enhanced odor discrimination and learning, the depletion of the GluR-B subunit should lead to a similar phenotypic readout.
T4144 1381-1383 IN denotes If
T4146 1384-1387 DT denotes the
T4148 1388-1392 NN denotes GluR
T4149 1392-1393 HYPH denotes -
T4063 1393-1394 NN denotes B
T4150 1394-1395 HYPH denotes /
T4151 1395-1399 NN denotes GluR
T4153 1399-1400 HYPH denotes -
T4152 1400-1401 NN denotes B
T4154 1401-1402 -LRB- denotes (
T4155 1402-1403 NN denotes Q
T4156 1403-1404 -RRB- denotes )
T4157 1405-1411 NN denotes switch
T4159 1411-1412 HYPH denotes -
T4158 1412-1419 VBN denotes induced
T4147 1420-1431 NNS denotes alterations
T4160 1432-1434 IN denotes in
T4161 1435-1438 DT denotes the
T4163 1439-1442 NN denotes Ca2
T4164 1442-1443 SYM denotes +
T4162 1444-1456 NN denotes permeability
T4165 1457-1459 IN denotes of
T4166 1460-1463 DT denotes the
T4168 1464-1468 NN denotes AMPA
T4167 1469-1477 NNS denotes channels
T4169 1478-1481 VBP denotes are
T4145 1482-1488 VBN denotes linked
T4171 1489-1491 IN denotes to
T4172 1492-1500 VBN denotes enhanced
T4174 1501-1505 NN denotes odor
T4173 1506-1520 NN denotes discrimination
T4175 1521-1524 CC denotes and
T4176 1525-1533 NN denotes learning
T4177 1533-1535 , denotes ,
T4178 1535-1538 DT denotes the
T4179 1539-1548 NN denotes depletion
T4180 1549-1551 IN denotes of
T4181 1552-1555 DT denotes the
T4183 1556-1560 NN denotes GluR
T4185 1560-1561 HYPH denotes -
T4184 1561-1562 NN denotes B
T4182 1563-1570 NN denotes subunit
T4186 1571-1577 MD denotes should
T4170 1578-1582 VB denotes lead
T4187 1583-1585 IN denotes to
T4188 1586-1587 DT denotes a
T4190 1588-1595 JJ denotes similar
T4191 1596-1606 JJ denotes phenotypic
T4189 1607-1614 NN denotes readout
T4192 1614-1615 . denotes .
R2641 T4063 T4147 nmod B,alterations
R2719 T4144 T4145 mark If,linked
R2720 T4145 T4170 advcl linked,lead
R2721 T4146 T4147 det the,alterations
R2722 T4147 T4145 nsubjpass alterations,linked
R2723 T4148 T4063 nmod GluR,B
R2724 T4149 T4063 punct -,B
R2725 T4150 T4063 punct /,B
R2726 T4151 T4152 compound GluR,B
R2727 T4152 T4063 appos B,B
R2728 T4153 T4152 punct -,B
R2729 T4154 T4155 punct (,Q
R2730 T4155 T4063 parataxis Q,B
R2731 T4156 T4155 punct ),Q
R2732 T4157 T4158 npadvmod switch,induced
R2733 T4158 T4147 amod induced,alterations
R2734 T4159 T4158 punct -,induced
R2735 T4160 T4147 prep in,alterations
R2736 T4161 T4162 det the,permeability
R2737 T4162 T4160 pobj permeability,in
R2738 T4163 T4162 nmod Ca2,permeability
R2739 T4164 T4163 punct +,Ca2
R2740 T4165 T4162 prep of,permeability
R2741 T4166 T4167 det the,channels
R2742 T4167 T4165 pobj channels,of
R2743 T4168 T4167 compound AMPA,channels
R2744 T4169 T4145 auxpass are,linked
R2745 T4171 T4145 prep to,linked
R2746 T4172 T4173 amod enhanced,discrimination
R2747 T4173 T4171 pobj discrimination,to
R2748 T4174 T4173 compound odor,discrimination
R2749 T4175 T4173 cc and,discrimination
R2750 T4176 T4173 conj learning,discrimination
R2751 T4177 T4170 punct ", ",lead
R2752 T4178 T4179 det the,depletion
R2753 T4179 T4170 nsubj depletion,lead
R2754 T4180 T4179 prep of,depletion
R2755 T4181 T4182 det the,subunit
R2756 T4182 T4180 pobj subunit,of
R2757 T4183 T4184 compound GluR,B
R2758 T4184 T4182 compound B,subunit
R2759 T4185 T4184 punct -,B
R2760 T4186 T4170 aux should,lead
R2761 T4187 T4170 prep to,lead
R2762 T4188 T4189 det a,readout
R2763 T4189 T4187 pobj readout,to
R2764 T4190 T4189 amod similar,readout
R2765 T4191 T4189 amod phenotypic,readout
R2766 T4192 T4170 punct .,lead