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PMC:1253828 / 32343-34429 JSONTXT 5 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T10519 0-3 PRP$ denotes Our
T10521 4-14 NN denotes expression
T10520 15-22 NNS denotes studies
T10523 23-27 RB denotes also
T10522 28-35 VBP denotes suggest
T10524 36-40 IN denotes that
T10526 41-44 NN denotes MTF
T10527 44-45 HYPH denotes -
T10528 45-46 CD denotes 1
T10525 47-56 VBZ denotes represses
T10529 57-62 JJ denotes basal
T10530 63-76 NN denotes transcription
T10531 77-79 IN denotes of
T10532 80-88 NN denotes Slc39a10
T10533 88-90 , denotes ,
T10534 90-92 IN denotes in
T10535 93-101 NN denotes contrast
T10536 102-104 IN denotes to
T10537 105-108 PRP$ denotes its
T10538 109-113 NN denotes role
T10539 114-116 IN denotes as
T10540 117-126 NN denotes activator
T10541 127-130 IN denotes for
T10542 131-134 DT denotes the
T10543 135-145 NN denotes expression
T10544 146-148 IN denotes of
T10545 149-154 JJ denotes other
T10547 155-161 NN denotes target
T10546 162-167 NNS denotes genes
T10548 168-172 IN denotes like
T10549 173-176 NN denotes Mt1
T10550 176-178 , denotes ,
T10551 178-181 NN denotes Mt2
T10552 181-183 , denotes ,
T10553 183-186 CC denotes and
T10554 187-191 NN denotes Znt1
T10555 192-193 -LRB- denotes (
T10557 193-194 CD denotes 4
T10558 194-195 , denotes ,
T10556 195-197 CD denotes 19
T10559 197-198 -RRB- denotes )
T10560 198-199 . denotes .
T10561 199-308 sentence denotes SLC39A10 is one of 14 mouse SLC39 members, which belong to the ZIP family of metal ion transporters (43,44).
T10562 200-208 NN denotes SLC39A10
T10563 209-211 VBZ denotes is
T10564 212-215 CD denotes one
T10565 216-218 IN denotes of
T10566 219-221 CD denotes 14
T10568 222-227 NN denotes mouse
T10569 228-233 NN denotes SLC39
T10567 234-241 NNS denotes members
T10570 241-243 , denotes ,
T10571 243-248 WDT denotes which
T10572 249-255 VBP denotes belong
T10573 256-258 IN denotes to
T10574 259-262 DT denotes the
T10576 263-266 NN denotes ZIP
T10575 267-273 NN denotes family
T10577 274-276 IN denotes of
T10578 277-282 NN denotes metal
T10579 283-286 NN denotes ion
T10580 287-299 NNS denotes transporters
T10581 300-301 -LRB- denotes (
T10583 301-303 CD denotes 43
T10584 303-304 , denotes ,
T10582 304-306 CD denotes 44
T10585 306-307 -RRB- denotes )
T10586 307-308 . denotes .
T10587 308-494 sentence denotes All members of the ZIP family characterized so far increase intracellular cytoplasmic metal ion concentrations by promoting extracellular and vesicular ion transport into the cytoplasm.
T10588 309-312 DT denotes All
T10589 313-320 NNS denotes members
T10591 321-323 IN denotes of
T10592 324-327 DT denotes the
T10594 328-331 NN denotes ZIP
T10593 332-338 NN denotes family
T10595 339-352 VBN denotes characterized
T10596 353-355 RB denotes so
T10597 356-359 RB denotes far
T10590 360-368 VBP denotes increase
T10598 369-382 JJ denotes intracellular
T10600 383-394 JJ denotes cytoplasmic
T10601 395-400 NN denotes metal
T10602 401-404 NN denotes ion
T10599 405-419 NNS denotes concentrations
T10603 420-422 IN denotes by
T10604 423-432 VBG denotes promoting
T10605 433-446 JJ denotes extracellular
T10607 447-450 CC denotes and
T10608 451-460 JJ denotes vesicular
T10609 461-464 NN denotes ion
T10606 465-474 NN denotes transport
T10610 475-479 IN denotes into
T10611 480-483 DT denotes the
T10612 484-493 NN denotes cytoplasm
T10613 493-494 . denotes .
T10614 494-597 sentence denotes ZIP proteins have been reported to be transporters of zinc, iron, manganese and/or cadmium (44,61–63).
T10615 495-498 NN denotes ZIP
T10616 499-507 NN denotes proteins
T10618 508-512 VBP denotes have
T10619 513-517 VBN denotes been
T10617 518-526 VBN denotes reported
T10620 527-529 TO denotes to
T10621 530-532 VB denotes be
T10622 533-545 NNS denotes transporters
T10623 546-548 IN denotes of
T10624 549-553 NN denotes zinc
T10625 553-555 , denotes ,
T10626 555-559 NN denotes iron
T10627 559-561 , denotes ,
T10628 561-570 NN denotes manganese
T10629 571-574 CC denotes and
T10630 574-575 HYPH denotes /
T10631 575-577 CC denotes or
T10632 578-585 NN denotes cadmium
T10633 586-587 -LRB- denotes (
T10634 587-589 CD denotes 44
T10635 589-590 , denotes ,
T10636 590-592 CD denotes 61
T10637 592-593 SYM denotes –
T10638 593-595 CD denotes 63
T10639 595-596 -RRB- denotes )
T10640 596-597 . denotes .
T10641 597-717 sentence denotes Although SLC39A10 is largely uncharacterized (44), it is referred to in several databases as putative zinc transporter.
T10642 598-606 IN denotes Although
T10644 607-615 NN denotes SLC39A10
T10643 616-618 VBZ denotes is
T10646 619-626 RB denotes largely
T10647 627-642 JJ denotes uncharacterized
T10648 643-644 -LRB- denotes (
T10649 644-646 CD denotes 44
T10650 646-647 -RRB- denotes )
T10651 647-649 , denotes ,
T10652 649-651 PRP denotes it
T10653 652-654 VBZ denotes is
T10645 655-663 VBN denotes referred
T10654 664-666 IN denotes to
T10655 667-669 IN denotes in
T10656 670-677 JJ denotes several
T10657 678-687 NNS denotes databases
T10658 688-690 IN denotes as
T10659 691-699 JJ denotes putative
T10661 700-704 NN denotes zinc
T10660 705-716 NN denotes transporter
T10662 716-717 . denotes .
T10663 717-845 sentence denotes It has been previously shown that MTF-1 is important for both basal expression and metal induction of the mouse Znt1 gene (19).
T10664 718-720 PRP denotes It
T10666 721-724 VBZ denotes has
T10667 725-729 VBN denotes been
T10668 730-740 RB denotes previously
T10665 741-746 VBN denotes shown
T10669 747-751 IN denotes that
T10671 752-755 NN denotes MTF
T10672 755-756 HYPH denotes -
T10673 756-757 CD denotes 1
T10670 758-760 VBZ denotes is
T10674 761-770 JJ denotes important
T10675 771-774 IN denotes for
T10676 775-779 CC denotes both
T10678 780-785 JJ denotes basal
T10677 786-796 NN denotes expression
T10679 797-800 CC denotes and
T10680 801-806 NN denotes metal
T10681 807-816 NN denotes induction
T10682 817-819 IN denotes of
T10683 820-823 DT denotes the
T10685 824-829 NN denotes mouse
T10686 830-834 NN denotes Znt1
T10684 835-839 NN denotes gene
T10687 840-841 -LRB- denotes (
T10688 841-843 CD denotes 19
T10689 843-844 -RRB- denotes )
T10690 844-845 . denotes .
T10691 845-1014 sentence denotes ZnT proteins represent a different family of transporters that reduce intracellular cytoplasmic zinc by promoting zinc efflux from cells or into intracellular vesicles.
T10692 846-849 NN denotes ZnT
T10693 850-858 NN denotes proteins
T10694 859-868 VBP denotes represent
T10695 869-870 DT denotes a
T10697 871-880 JJ denotes different
T10696 881-887 NN denotes family
T10698 888-890 IN denotes of
T10699 891-903 NNS denotes transporters
T10700 904-908 WDT denotes that
T10701 909-915 VBP denotes reduce
T10702 916-929 JJ denotes intracellular
T10704 930-941 JJ denotes cytoplasmic
T10703 942-946 NN denotes zinc
T10705 947-949 IN denotes by
T10706 950-959 VBG denotes promoting
T10707 960-964 NN denotes zinc
T10708 965-971 NN denotes efflux
T10709 972-976 IN denotes from
T10710 977-982 NNS denotes cells
T10711 983-985 CC denotes or
T10712 986-990 IN denotes into
T10713 991-1004 JJ denotes intracellular
T10714 1005-1013 NNS denotes vesicles
T10715 1013-1014 . denotes .
T10716 1014-1144 sentence denotes Thus, members of the ZnT and ZIP family with zinc as predominant substrate have opposite roles in cellular zinc homeostasis (43).
T10717 1015-1019 RB denotes Thus
T10719 1019-1021 , denotes ,
T10720 1021-1028 NNS denotes members
T10721 1029-1031 IN denotes of
T10722 1032-1035 DT denotes the
T10724 1036-1039 NN denotes ZnT
T10725 1040-1043 CC denotes and
T10726 1044-1047 NN denotes ZIP
T10723 1048-1054 NN denotes family
T10727 1055-1059 IN denotes with
T10728 1060-1064 NN denotes zinc
T10729 1065-1067 IN denotes as
T10730 1068-1079 JJ denotes predominant
T10731 1080-1089 NN denotes substrate
T10718 1090-1094 VBP denotes have
T10732 1095-1103 JJ denotes opposite
T10733 1104-1109 NNS denotes roles
T10734 1110-1112 IN denotes in
T10735 1113-1121 JJ denotes cellular
T10737 1122-1126 NN denotes zinc
T10736 1127-1138 NN denotes homeostasis
T10738 1139-1140 -LRB- denotes (
T10739 1140-1142 CD denotes 43
T10740 1142-1143 -RRB- denotes )
T10741 1143-1144 . denotes .
T10742 1144-1309 sentence denotes Assuming that SLC39A10 is indeed a zinc transporter, MTF-1 would control expression of two zinc transporters with antagonistic functions, namely, Znt1 and Slc39a10.
T10743 1145-1153 VBG denotes Assuming
T10745 1154-1158 IN denotes that
T10747 1159-1167 NN denotes SLC39A10
T10746 1168-1170 VBZ denotes is
T10748 1171-1177 RB denotes indeed
T10749 1178-1179 DT denotes a
T10751 1180-1184 NN denotes zinc
T10750 1185-1196 NN denotes transporter
T10752 1196-1198 , denotes ,
T10753 1198-1201 NN denotes MTF
T10754 1201-1202 HYPH denotes -
T10755 1202-1203 CD denotes 1
T10756 1204-1209 MD denotes would
T10744 1210-1217 VB denotes control
T10757 1218-1228 NN denotes expression
T10758 1229-1231 IN denotes of
T10759 1232-1235 CD denotes two
T10761 1236-1240 NN denotes zinc
T10760 1241-1253 NNS denotes transporters
T10762 1254-1258 IN denotes with
T10763 1259-1271 JJ denotes antagonistic
T10764 1272-1281 NNS denotes functions
T10765 1281-1283 , denotes ,
T10766 1283-1289 RB denotes namely
T10768 1289-1291 , denotes ,
T10767 1291-1295 NN denotes Znt1
T10769 1296-1299 CC denotes and
T10770 1300-1308 NN denotes Slc39a10
T10771 1308-1309 . denotes .
T10772 1309-1420 sentence denotes Specific binding of MTF-1 was observed for an MRE located just downstream of the Slc39a10 transcription start.
T10773 1310-1318 JJ denotes Specific
T10774 1319-1326 NN denotes binding
T10776 1327-1329 IN denotes of
T10777 1330-1333 NN denotes MTF
T10778 1333-1334 HYPH denotes -
T10779 1334-1335 CD denotes 1
T10780 1336-1339 VBD denotes was
T10775 1340-1348 VBN denotes observed
T10781 1349-1352 IN denotes for
T10782 1353-1355 DT denotes an
T10783 1356-1359 NN denotes MRE
T10784 1360-1367 VBN denotes located
T10785 1368-1372 RB denotes just
T10786 1373-1383 RB denotes downstream
T10787 1384-1386 IN denotes of
T10788 1387-1390 DT denotes the
T10790 1391-1399 NN denotes Slc39a10
T10791 1400-1413 NN denotes transcription
T10789 1414-1419 NN denotes start
T10792 1419-1420 . denotes .
T10793 1420-1641 sentence denotes In a simple model, such a binding could interfere with the accessibility of the transcriptional start site for RNA polymerase II and/or general transcription factors, thus preventing transcription initiation of the gene.
T10794 1421-1423 IN denotes In
T10796 1424-1425 DT denotes a
T10798 1426-1432 JJ denotes simple
T10797 1433-1438 NN denotes model
T10799 1438-1440 , denotes ,
T10800 1440-1444 PDT denotes such
T10802 1445-1446 DT denotes a
T10801 1447-1454 NN denotes binding
T10803 1455-1460 MD denotes could
T10795 1461-1470 VB denotes interfere
T10804 1471-1475 IN denotes with
T10805 1476-1479 DT denotes the
T10806 1480-1493 NN denotes accessibility
T10807 1494-1496 IN denotes of
T10808 1497-1500 DT denotes the
T10810 1501-1516 JJ denotes transcriptional
T10811 1517-1522 NN denotes start
T10809 1523-1527 NN denotes site
T10812 1528-1531 IN denotes for
T10813 1532-1535 NN denotes RNA
T10814 1536-1546 NN denotes polymerase
T10815 1547-1549 CD denotes II
T10816 1550-1553 CC denotes and
T10817 1553-1554 HYPH denotes /
T10818 1554-1556 CC denotes or
T10819 1557-1564 JJ denotes general
T10821 1565-1578 NN denotes transcription
T10820 1579-1586 NNS denotes factors
T10822 1586-1588 , denotes ,
T10823 1588-1592 RB denotes thus
T10824 1593-1603 VBG denotes preventing
T10825 1604-1617 NN denotes transcription
T10826 1618-1628 NN denotes initiation
T10827 1629-1631 IN denotes of
T10828 1632-1635 DT denotes the
T10829 1636-1640 NN denotes gene
T10830 1640-1641 . denotes .
T10831 1641-1808 sentence denotes Indeed, such a mechanism has been described in yeast for the zinc-responsive activator protein 1 (Zap1) and its target gene, zinc-regulated transporter 2 (ZRT2) (64).
T10832 1642-1648 RB denotes Indeed
T10834 1648-1650 , denotes ,
T10835 1650-1654 PDT denotes such
T10837 1655-1656 DT denotes a
T10836 1657-1666 NN denotes mechanism
T10838 1667-1670 VBZ denotes has
T10839 1671-1675 VBN denotes been
T10833 1676-1685 VBN denotes described
T10840 1686-1688 IN denotes in
T10841 1689-1694 NN denotes yeast
T10842 1695-1698 IN denotes for
T10843 1699-1702 DT denotes the
T10845 1703-1707 NN denotes zinc
T10847 1707-1708 HYPH denotes -
T10846 1708-1718 JJ denotes responsive
T10848 1719-1728 NN denotes activator
T10844 1729-1736 NN denotes protein
T10849 1737-1738 CD denotes 1
T10850 1739-1740 -LRB- denotes (
T10851 1740-1744 NN denotes Zap1
T10852 1744-1745 -RRB- denotes )
T10853 1746-1749 CC denotes and
T10854 1750-1753 PRP$ denotes its
T10856 1754-1760 NN denotes target
T10855 1761-1765 NN denotes gene
T10857 1765-1767 , denotes ,
T10858 1767-1771 NN denotes zinc
T10860 1771-1772 HYPH denotes -
T10861 1772-1781 VBN denotes regulated
T10859 1782-1793 NN denotes transporter
T10862 1794-1795 CD denotes 2
T10863 1796-1797 -LRB- denotes (
T10864 1797-1801 NN denotes ZRT2
T10865 1801-1802 -RRB- denotes )
T10866 1803-1804 -LRB- denotes (
T10867 1804-1806 CD denotes 64
T10868 1806-1807 -RRB- denotes )
T10869 1807-1808 . denotes .
T10870 1808-1930 sentence denotes However, the inhibition of Slc39a10 expression by MTF-1 may well be more complex than a competition for promoter binding.
T10871 1809-1816 RB denotes However
T10873 1816-1818 , denotes ,
T10874 1818-1821 DT denotes the
T10875 1822-1832 NN denotes inhibition
T10876 1833-1835 IN denotes of
T10877 1836-1844 NN denotes Slc39a10
T10878 1845-1855 NN denotes expression
T10879 1856-1858 IN denotes by
T10880 1859-1862 NN denotes MTF
T10881 1862-1863 HYPH denotes -
T10882 1863-1864 CD denotes 1
T10883 1865-1868 MD denotes may
T10884 1869-1873 RB denotes well
T10872 1874-1876 VB denotes be
T10885 1877-1881 RBR denotes more
T10886 1882-1889 JJ denotes complex
T10887 1890-1894 IN denotes than
T10888 1895-1896 DT denotes a
T10889 1897-1908 NN denotes competition
T10890 1909-1912 IN denotes for
T10891 1913-1921 NN denotes promoter
T10892 1922-1929 NN denotes binding
T10893 1929-1930 . denotes .
T10894 1930-2086 sentence denotes Independent of MTF-1, cadmium treatment also leads to downregulation of Slc39a10 transcripts, suggesting that some other factor is mediating this response.
T10895 1931-1942 JJ denotes Independent
T10897 1943-1945 IN denotes of
T10898 1946-1949 NN denotes MTF
T10899 1949-1950 HYPH denotes -
T10900 1950-1951 CD denotes 1
T10901 1951-1953 , denotes ,
T10902 1953-1960 NN denotes cadmium
T10903 1961-1970 NN denotes treatment
T10904 1971-1975 RB denotes also
T10896 1976-1981 VBZ denotes leads
T10905 1982-1984 IN denotes to
T10906 1985-1999 NN denotes downregulation
T10907 2000-2002 IN denotes of
T10908 2003-2011 NN denotes Slc39a10
T10909 2012-2023 NNS denotes transcripts
T10910 2023-2025 , denotes ,
T10911 2025-2035 VBG denotes suggesting
T10912 2036-2040 IN denotes that
T10914 2041-2045 DT denotes some
T10916 2046-2051 JJ denotes other
T10915 2052-2058 NN denotes factor
T10917 2059-2061 VBZ denotes is
T10913 2062-2071 VBG denotes mediating
T10918 2072-2076 DT denotes this
T10919 2077-2085 NN denotes response
T10920 2085-2086 . denotes .
R6254 T10519 T10520 poss Our,studies
R6255 T10520 T10522 nsubj studies,suggest
R6256 T10521 T10520 compound expression,studies
R6257 T10523 T10522 advmod also,suggest
R6258 T10524 T10525 mark that,represses
R6259 T10525 T10522 ccomp represses,suggest
R6260 T10526 T10525 nsubj MTF,represses
R6261 T10527 T10526 punct -,MTF
R6262 T10528 T10526 nummod 1,MTF
R6263 T10529 T10530 amod basal,transcription
R6264 T10530 T10525 dobj transcription,represses
R6265 T10531 T10530 prep of,transcription
R6266 T10532 T10531 pobj Slc39a10,of
R6267 T10533 T10525 punct ", ",represses
R6268 T10534 T10525 prep in,represses
R6269 T10535 T10534 pobj contrast,in
R6270 T10536 T10535 prep to,contrast
R6271 T10537 T10538 poss its,role
R6272 T10538 T10536 pobj role,to
R6273 T10539 T10538 prep as,role
R6274 T10540 T10539 pobj activator,as
R6275 T10541 T10540 prep for,activator
R6276 T10542 T10543 det the,expression
R6277 T10543 T10541 pobj expression,for
R6278 T10544 T10543 prep of,expression
R6279 T10545 T10546 amod other,genes
R6280 T10546 T10544 pobj genes,of
R6281 T10547 T10546 compound target,genes
R6282 T10548 T10546 prep like,genes
R6283 T10549 T10548 pobj Mt1,like
R6284 T10550 T10549 punct ", ",Mt1
R6285 T10551 T10549 conj Mt2,Mt1
R6286 T10552 T10551 punct ", ",Mt2
R6287 T10553 T10551 cc and,Mt2
R6288 T10554 T10551 conj Znt1,Mt2
R6289 T10555 T10556 punct (,19
R6290 T10556 T10525 parataxis 19,represses
R6291 T10557 T10556 nummod 4,19
R6292 T10558 T10556 punct ",",19
R6293 T10559 T10556 punct ),19
R6294 T10560 T10522 punct .,suggest
R6295 T10562 T10563 nsubj SLC39A10,is
R6296 T10564 T10563 attr one,is
R6297 T10565 T10564 prep of,one
R6298 T10566 T10567 nummod 14,members
R6299 T10567 T10565 pobj members,of
R6300 T10568 T10567 compound mouse,members
R6301 T10569 T10567 compound SLC39,members
R6302 T10570 T10567 punct ", ",members
R6303 T10571 T10572 dep which,belong
R6304 T10572 T10567 relcl belong,members
R6305 T10573 T10572 prep to,belong
R6306 T10574 T10575 det the,family
R6307 T10575 T10573 pobj family,to
R6308 T10576 T10575 compound ZIP,family
R6309 T10577 T10575 prep of,family
R6310 T10578 T10579 compound metal,ion
R6311 T10579 T10580 compound ion,transporters
R6312 T10580 T10577 pobj transporters,of
R6313 T10581 T10582 punct (,44
R6314 T10582 T10572 parataxis 44,belong
R6315 T10583 T10582 nummod 43,44
R6316 T10584 T10582 punct ",",44
R6317 T10585 T10582 punct ),44
R6318 T10586 T10563 punct .,is
R6319 T10588 T10589 det All,members
R6320 T10589 T10590 nsubj members,increase
R6321 T10591 T10589 prep of,members
R6322 T10592 T10593 det the,family
R6323 T10593 T10591 pobj family,of
R6324 T10594 T10593 compound ZIP,family
R6325 T10595 T10589 acl characterized,members
R6326 T10596 T10597 advmod so,far
R6327 T10597 T10595 advmod far,characterized
R6328 T10598 T10599 amod intracellular,concentrations
R6329 T10599 T10590 dobj concentrations,increase
R6330 T10600 T10599 amod cytoplasmic,concentrations
R6331 T10601 T10602 compound metal,ion
R6332 T10602 T10599 compound ion,concentrations
R6333 T10603 T10590 prep by,increase
R6334 T10604 T10603 pcomp promoting,by
R6335 T10605 T10606 amod extracellular,transport
R6336 T10606 T10604 dobj transport,promoting
R6337 T10607 T10605 cc and,extracellular
R6338 T10608 T10605 conj vesicular,extracellular
R6339 T10609 T10606 compound ion,transport
R6340 T10610 T10606 prep into,transport
R6341 T10611 T10612 det the,cytoplasm
R6342 T10612 T10610 pobj cytoplasm,into
R6343 T10613 T10590 punct .,increase
R6344 T10615 T10616 compound ZIP,proteins
R6345 T10616 T10617 nsubjpass proteins,reported
R6346 T10618 T10617 aux have,reported
R6347 T10619 T10617 auxpass been,reported
R6348 T10620 T10621 aux to,be
R6349 T10621 T10617 xcomp be,reported
R6350 T10622 T10621 attr transporters,be
R6351 T10623 T10622 prep of,transporters
R6352 T10624 T10623 pobj zinc,of
R6353 T10625 T10624 punct ", ",zinc
R6354 T10626 T10624 conj iron,zinc
R6355 T10627 T10626 punct ", ",iron
R6356 T10628 T10626 conj manganese,iron
R6357 T10629 T10628 cc and,manganese
R6358 T10630 T10629 punct /,and
R6359 T10631 T10629 cc or,and
R6360 T10632 T10628 conj cadmium,manganese
R6361 T10633 T10634 punct (,44
R6362 T10634 T10621 parataxis 44,be
R6363 T10635 T10634 punct ",",44
R6364 T10636 T10634 appos 61,44
R6365 T10637 T10638 punct –,63
R6366 T10638 T10636 prep 63,61
R6367 T10639 T10634 punct ),44
R6368 T10640 T10617 punct .,reported
R6369 T10642 T10643 mark Although,is
R6370 T10643 T10645 advcl is,referred
R6371 T10644 T10643 nsubj SLC39A10,is
R6372 T10646 T10647 advmod largely,uncharacterized
R6373 T10647 T10643 acomp uncharacterized,is
R6374 T10648 T10649 punct (,44
R6375 T10649 T10643 parataxis 44,is
R6376 T10650 T10649 punct ),44
R6377 T10651 T10645 punct ", ",referred
R6378 T10652 T10645 nsubjpass it,referred
R6379 T10653 T10645 auxpass is,referred
R6380 T10654 T10645 prep to,referred
R6381 T10655 T10645 prep in,referred
R6382 T10656 T10657 amod several,databases
R6383 T10657 T10655 pobj databases,in
R6384 T10658 T10645 prep as,referred
R6385 T10659 T10660 amod putative,transporter
R6386 T10660 T10658 pobj transporter,as
R6387 T10661 T10660 compound zinc,transporter
R6388 T10662 T10645 punct .,referred
R6389 T10664 T10665 nsubjpass It,shown
R6390 T10666 T10665 aux has,shown
R6391 T10667 T10665 auxpass been,shown
R6392 T10668 T10665 advmod previously,shown
R6393 T10669 T10670 mark that,is
R6394 T10670 T10665 ccomp is,shown
R6395 T10671 T10670 nsubj MTF,is
R6396 T10672 T10671 punct -,MTF
R6397 T10673 T10671 nummod 1,MTF
R6398 T10674 T10670 acomp important,is
R6399 T10675 T10674 prep for,important
R6400 T10676 T10677 preconj both,expression
R6401 T10677 T10675 pobj expression,for
R6402 T10678 T10677 amod basal,expression
R6403 T10679 T10677 cc and,expression
R6404 T10680 T10681 compound metal,induction
R6405 T10681 T10677 conj induction,expression
R6406 T10682 T10677 prep of,expression
R6407 T10683 T10684 det the,gene
R6408 T10684 T10682 pobj gene,of
R6409 T10685 T10684 compound mouse,gene
R6410 T10686 T10684 compound Znt1,gene
R6411 T10687 T10688 punct (,19
R6412 T10688 T10670 parataxis 19,is
R6413 T10689 T10688 punct ),19
R6414 T10690 T10665 punct .,shown
R6415 T10692 T10693 compound ZnT,proteins
R6416 T10693 T10694 nsubj proteins,represent
R6417 T10695 T10696 det a,family
R6418 T10696 T10694 dobj family,represent
R6419 T10697 T10696 amod different,family
R6420 T10698 T10696 prep of,family
R6421 T10699 T10698 pobj transporters,of
R6422 T10700 T10701 dep that,reduce
R6423 T10701 T10696 relcl reduce,family
R6424 T10702 T10703 amod intracellular,zinc
R6425 T10703 T10701 dobj zinc,reduce
R6426 T10704 T10703 amod cytoplasmic,zinc
R6427 T10705 T10701 prep by,reduce
R6428 T10706 T10705 pcomp promoting,by
R6429 T10707 T10708 compound zinc,efflux
R6430 T10708 T10706 dobj efflux,promoting
R6431 T10709 T10708 prep from,efflux
R6432 T10710 T10709 pobj cells,from
R6433 T10711 T10709 cc or,from
R6434 T10712 T10709 conj into,from
R6435 T10713 T10714 amod intracellular,vesicles
R6436 T10714 T10712 pobj vesicles,into
R6437 T10715 T10694 punct .,represent
R6438 T10717 T10718 advmod Thus,have
R6439 T10719 T10718 punct ", ",have
R6440 T10720 T10718 nsubj members,have
R6441 T10721 T10720 prep of,members
R6442 T10722 T10723 det the,family
R6443 T10723 T10721 pobj family,of
R6444 T10724 T10723 nmod ZnT,family
R6445 T10725 T10724 cc and,ZnT
R6446 T10726 T10724 conj ZIP,ZnT
R6447 T10727 T10720 prep with,members
R6448 T10728 T10727 pobj zinc,with
R6449 T10729 T10728 prep as,zinc
R6450 T10730 T10731 amod predominant,substrate
R6451 T10731 T10729 pobj substrate,as
R6452 T10732 T10733 amod opposite,roles
R6453 T10733 T10718 dobj roles,have
R6454 T10734 T10733 prep in,roles
R6455 T10735 T10736 amod cellular,homeostasis
R6456 T10736 T10734 pobj homeostasis,in
R6457 T10737 T10736 compound zinc,homeostasis
R6458 T10738 T10739 punct (,43
R6459 T10739 T10718 parataxis 43,have
R6460 T10740 T10739 punct ),43
R6461 T10741 T10718 punct .,have
R6462 T10743 T10744 advcl Assuming,control
R6463 T10745 T10746 mark that,is
R6464 T10746 T10743 ccomp is,Assuming
R6465 T10747 T10746 nsubj SLC39A10,is
R6466 T10748 T10746 advmod indeed,is
R6467 T10749 T10750 det a,transporter
R6468 T10750 T10746 attr transporter,is
R6469 T10751 T10750 compound zinc,transporter
R6470 T10752 T10744 punct ", ",control
R6471 T10753 T10744 nsubj MTF,control
R6472 T10754 T10753 punct -,MTF
R6473 T10755 T10753 nummod 1,MTF
R6474 T10756 T10744 aux would,control
R6475 T10757 T10744 dobj expression,control
R6476 T10758 T10757 prep of,expression
R6477 T10759 T10760 nummod two,transporters
R6478 T10760 T10758 pobj transporters,of
R6479 T10761 T10760 compound zinc,transporters
R6480 T10762 T10760 prep with,transporters
R6481 T10763 T10764 amod antagonistic,functions
R6482 T10764 T10762 pobj functions,with
R6483 T10765 T10760 punct ", ",transporters
R6484 T10766 T10767 advmod namely,Znt1
R6485 T10767 T10760 appos Znt1,transporters
R6486 T10768 T10767 punct ", ",Znt1
R6487 T10769 T10767 cc and,Znt1
R6488 T10770 T10767 conj Slc39a10,Znt1
R6489 T10771 T10744 punct .,control
R6490 T10773 T10774 amod Specific,binding
R6491 T10774 T10775 nsubjpass binding,observed
R6492 T10776 T10774 prep of,binding
R6493 T10777 T10776 pobj MTF,of
R6494 T10778 T10777 punct -,MTF
R6495 T10779 T10777 nummod 1,MTF
R6496 T10780 T10775 auxpass was,observed
R6497 T10781 T10775 prep for,observed
R6498 T10782 T10783 det an,MRE
R6499 T10783 T10781 pobj MRE,for
R6500 T10784 T10783 acl located,MRE
R6501 T10785 T10786 advmod just,downstream
R6502 T10786 T10784 advmod downstream,located
R6503 T10787 T10786 prep of,downstream
R6504 T10788 T10789 det the,start
R6505 T10789 T10787 pobj start,of
R6506 T10790 T10789 compound Slc39a10,start
R6507 T10791 T10789 compound transcription,start
R6508 T10792 T10775 punct .,observed
R6509 T10794 T10795 prep In,interfere
R6510 T10796 T10797 det a,model
R6511 T10797 T10794 pobj model,In
R6512 T10798 T10797 amod simple,model
R6513 T10799 T10795 punct ", ",interfere
R6514 T10800 T10801 predet such,binding
R6515 T10801 T10795 nsubj binding,interfere
R6516 T10802 T10801 det a,binding
R6517 T10803 T10795 aux could,interfere
R6518 T10804 T10795 prep with,interfere
R6519 T10805 T10806 det the,accessibility
R6520 T10806 T10804 pobj accessibility,with
R6521 T10807 T10806 prep of,accessibility
R6522 T10808 T10809 det the,site
R6523 T10809 T10807 pobj site,of
R6524 T10810 T10809 amod transcriptional,site
R6525 T10811 T10809 compound start,site
R6526 T10812 T10809 prep for,site
R6527 T10813 T10814 compound RNA,polymerase
R6528 T10814 T10812 pobj polymerase,for
R6529 T10815 T10814 nummod II,polymerase
R6530 T10816 T10814 cc and,polymerase
R6531 T10817 T10816 punct /,and
R6532 T10818 T10816 cc or,and
R6533 T10819 T10820 amod general,factors
R6534 T10820 T10814 conj factors,polymerase
R6535 T10821 T10820 compound transcription,factors
R6536 T10822 T10795 punct ", ",interfere
R6537 T10823 T10824 advmod thus,preventing
R6538 T10824 T10795 advcl preventing,interfere
R6539 T10825 T10826 compound transcription,initiation
R6540 T10826 T10824 dobj initiation,preventing
R6541 T10827 T10826 prep of,initiation
R6542 T10828 T10829 det the,gene
R6543 T10829 T10827 pobj gene,of
R6544 T10830 T10795 punct .,interfere
R6545 T10832 T10833 advmod Indeed,described
R6546 T10834 T10833 punct ", ",described
R6547 T10835 T10836 predet such,mechanism
R6548 T10836 T10833 nsubjpass mechanism,described
R6549 T10837 T10836 det a,mechanism
R6550 T10838 T10833 aux has,described
R6551 T10839 T10833 auxpass been,described
R6552 T10840 T10833 prep in,described
R6553 T10841 T10840 pobj yeast,in
R6554 T10842 T10833 prep for,described
R6555 T10843 T10844 det the,protein
R6556 T10844 T10842 pobj protein,for
R6557 T10845 T10846 npadvmod zinc,responsive
R6558 T10846 T10844 amod responsive,protein
R6559 T10847 T10846 punct -,responsive
R6560 T10848 T10844 compound activator,protein
R6561 T10849 T10844 nummod 1,protein
R6562 T10850 T10844 punct (,protein
R6563 T10851 T10844 appos Zap1,protein
R6564 T10852 T10844 punct ),protein
R6565 T10853 T10844 cc and,protein
R6566 T10854 T10855 poss its,gene
R6567 T10855 T10844 conj gene,protein
R6568 T10856 T10855 compound target,gene
R6569 T10857 T10855 punct ", ",gene
R6570 T10858 T10859 nmod zinc,transporter
R6571 T10859 T10855 appos transporter,gene
R6572 T10860 T10859 punct -,transporter
R6573 T10861 T10859 amod regulated,transporter
R6574 T10862 T10859 nummod 2,transporter
R6575 T10863 T10859 punct (,transporter
R6576 T10864 T10859 appos ZRT2,transporter
R6577 T10865 T10833 punct ),described
R6578 T10866 T10867 punct (,64
R6579 T10867 T10833 parataxis 64,described
R6580 T10868 T10867 punct ),64
R6581 T10869 T10833 punct .,described
R6582 T10871 T10872 advmod However,be
R6583 T10873 T10872 punct ", ",be
R6584 T10874 T10875 det the,inhibition
R6585 T10875 T10872 nsubj inhibition,be
R6586 T10876 T10875 prep of,inhibition
R6587 T10877 T10878 compound Slc39a10,expression
R6588 T10878 T10876 pobj expression,of
R6589 T10879 T10875 prep by,inhibition
R6590 T10880 T10879 pobj MTF,by
R6591 T10881 T10880 punct -,MTF
R6592 T10882 T10880 nummod 1,MTF
R6593 T10883 T10872 aux may,be
R6594 T10884 T10872 advmod well,be
R6595 T10885 T10886 advmod more,complex
R6596 T10886 T10872 acomp complex,be
R6597 T10887 T10886 prep than,complex
R6598 T10888 T10889 det a,competition
R6599 T10889 T10887 pobj competition,than
R6600 T10890 T10889 prep for,competition
R6601 T10891 T10892 compound promoter,binding
R6602 T10892 T10890 pobj binding,for
R6603 T10893 T10872 punct .,be
R6604 T10895 T10896 advcl Independent,leads
R6605 T10897 T10895 prep of,Independent
R6606 T10898 T10897 pobj MTF,of
R6607 T10899 T10898 punct -,MTF
R6608 T10900 T10898 nummod 1,MTF
R6609 T10901 T10896 punct ", ",leads
R6610 T10902 T10903 compound cadmium,treatment
R6611 T10903 T10896 nsubj treatment,leads
R6612 T10904 T10896 advmod also,leads
R6613 T10905 T10896 prep to,leads
R6614 T10906 T10905 pobj downregulation,to
R6615 T10907 T10906 prep of,downregulation
R6616 T10908 T10909 compound Slc39a10,transcripts
R6617 T10909 T10907 pobj transcripts,of
R6618 T10910 T10896 punct ", ",leads
R6619 T10911 T10896 advcl suggesting,leads
R6620 T10912 T10913 mark that,mediating
R6621 T10913 T10911 ccomp mediating,suggesting
R6622 T10914 T10915 det some,factor
R6623 T10915 T10913 nsubj factor,mediating
R6624 T10916 T10915 amod other,factor
R6625 T10917 T10913 aux is,mediating
R6626 T10918 T10919 det this,response
R6627 T10919 T10913 dobj response,mediating
R6628 T10920 T10896 punct .,leads