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PMC:1253828 / 2876-4204 JSONTXT 5 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T1215 0-3 DT denotes The
T1216 4-8 NN denotes role
T1218 9-11 IN denotes of
T1219 12-15 NN denotes MTF
T1220 15-16 HYPH denotes -
T1221 16-17 CD denotes 1
T1222 18-21 VBZ denotes has
T1223 22-26 VBN denotes been
T1217 27-34 VBN denotes studied
T1224 35-39 RBS denotes most
T1225 40-51 RB denotes extensively
T1226 52-54 IN denotes in
T1227 55-58 DT denotes the
T1228 59-64 NN denotes mouse
T1229 64-65 . denotes .
T1230 65-242 sentence denotes Besides coping with heavy metal load, MTF-1 can also mediate the induction of Mt genes in response to other stress situations, such as oxidative stress (5,17) and hypoxia (18).
T1231 66-73 IN denotes Besides
T1233 74-80 VBG denotes coping
T1234 81-85 IN denotes with
T1235 86-91 JJ denotes heavy
T1236 92-97 NN denotes metal
T1237 98-102 NN denotes load
T1238 102-104 , denotes ,
T1239 104-107 NN denotes MTF
T1240 107-108 HYPH denotes -
T1241 108-109 CD denotes 1
T1242 110-113 MD denotes can
T1243 114-118 RB denotes also
T1232 119-126 VB denotes mediate
T1244 127-130 DT denotes the
T1245 131-140 NN denotes induction
T1246 141-143 IN denotes of
T1247 144-146 NN denotes Mt
T1248 147-152 NNS denotes genes
T1249 153-155 IN denotes in
T1250 156-164 NN denotes response
T1251 165-167 IN denotes to
T1252 168-173 JJ denotes other
T1254 174-180 NN denotes stress
T1253 181-191 NNS denotes situations
T1255 191-193 , denotes ,
T1256 193-197 JJ denotes such
T1257 198-200 IN denotes as
T1258 201-210 JJ denotes oxidative
T1259 211-217 NN denotes stress
T1260 218-219 -LRB- denotes (
T1262 219-220 CD denotes 5
T1263 220-221 , denotes ,
T1261 221-223 CD denotes 17
T1264 223-224 -RRB- denotes )
T1265 225-228 CC denotes and
T1266 229-236 NN denotes hypoxia
T1267 237-238 -LRB- denotes (
T1268 238-240 CD denotes 18
T1269 240-241 -RRB- denotes )
T1270 241-242 . denotes .
T1271 242-601 sentence denotes In addition, it is required for the metalloregulation of Znt1, encoding the major plasma membrane-localized zinc efflux transporter (19), the hypoxic/anoxic induction of the gene for placental growth factor (Plgf), an angiogenic protein of the vascular endothelial growth factor (VEGF) family (20), and has recently been invoked in tumor development (21,22).
T1272 243-245 IN denotes In
T1274 246-254 NN denotes addition
T1275 254-256 , denotes ,
T1276 256-258 PRP denotes it
T1277 259-261 VBZ denotes is
T1273 262-270 VBN denotes required
T1278 271-274 IN denotes for
T1279 275-278 DT denotes the
T1280 279-296 NN denotes metalloregulation
T1281 297-299 IN denotes of
T1282 300-304 NN denotes Znt1
T1283 304-306 , denotes ,
T1284 306-314 VBG denotes encoding
T1285 315-318 DT denotes the
T1287 319-324 JJ denotes major
T1288 325-331 NN denotes plasma
T1289 332-340 NN denotes membrane
T1291 340-341 HYPH denotes -
T1290 341-350 VBN denotes localized
T1292 351-355 NN denotes zinc
T1293 356-362 NN denotes efflux
T1286 363-374 NN denotes transporter
T1294 375-376 -LRB- denotes (
T1295 376-378 CD denotes 19
T1296 378-379 -RRB- denotes )
T1297 379-381 , denotes ,
T1298 381-384 DT denotes the
T1300 385-392 JJ denotes hypoxic
T1302 392-393 HYPH denotes /
T1301 393-399 JJ denotes anoxic
T1299 400-409 NN denotes induction
T1303 410-412 IN denotes of
T1304 413-416 DT denotes the
T1305 417-421 NN denotes gene
T1306 422-425 IN denotes for
T1307 426-435 JJ denotes placental
T1309 436-442 NN denotes growth
T1308 443-449 NN denotes factor
T1310 450-451 -LRB- denotes (
T1311 451-455 NN denotes Plgf
T1312 455-456 -RRB- denotes )
T1313 456-458 , denotes ,
T1314 458-460 DT denotes an
T1316 461-471 JJ denotes angiogenic
T1315 472-479 NN denotes protein
T1317 480-482 IN denotes of
T1318 483-486 DT denotes the
T1320 487-495 JJ denotes vascular
T1322 496-507 JJ denotes endothelial
T1323 508-514 NN denotes growth
T1321 515-521 NN denotes factor
T1324 522-523 -LRB- denotes (
T1325 523-527 NN denotes VEGF
T1326 527-528 -RRB- denotes )
T1319 529-535 NN denotes family
T1327 536-537 -LRB- denotes (
T1328 537-539 CD denotes 20
T1329 539-540 -RRB- denotes )
T1330 540-542 , denotes ,
T1331 542-545 CC denotes and
T1332 546-549 VBZ denotes has
T1334 550-558 RB denotes recently
T1335 559-563 VBN denotes been
T1333 564-571 VBN denotes invoked
T1336 572-574 IN denotes in
T1337 575-580 NN denotes tumor
T1338 581-592 NN denotes development
T1339 593-594 -LRB- denotes (
T1341 594-596 CD denotes 21
T1342 596-597 , denotes ,
T1340 597-599 CD denotes 22
T1343 599-600 -RRB- denotes )
T1344 600-601 . denotes .
T1345 601-787 sentence denotes Furthermore, MTF-1 has an essential function during embryogenesis: targeted disruption of Mtf1 results in embryonic lethality around 14 days post coitum due to hepatocyte necrosis (23).
T1346 602-613 RB denotes Furthermore
T1348 613-615 , denotes ,
T1349 615-618 NN denotes MTF
T1350 618-619 HYPH denotes -
T1351 619-620 CD denotes 1
T1347 621-624 VBZ denotes has
T1353 625-627 DT denotes an
T1355 628-637 JJ denotes essential
T1354 638-646 NN denotes function
T1356 647-653 IN denotes during
T1357 654-667 NN denotes embryogenesis
T1358 667-669 : denotes :
T1359 669-677 VBN denotes targeted
T1360 678-688 NN denotes disruption
T1361 689-691 IN denotes of
T1362 692-696 NN denotes Mtf1
T1352 697-704 VBZ denotes results
T1363 705-707 IN denotes in
T1364 708-717 JJ denotes embryonic
T1365 718-727 NN denotes lethality
T1366 728-734 IN denotes around
T1367 735-737 CD denotes 14
T1368 738-742 NNS denotes days
T1369 743-747 FW denotes post
T1370 748-754 FW denotes coitum
T1371 755-758 IN denotes due
T1372 759-761 IN denotes to
T1373 762-772 NN denotes hepatocyte
T1374 773-781 NN denotes necrosis
T1375 782-783 -LRB- denotes (
T1376 783-785 CD denotes 23
T1377 785-786 -RRB- denotes )
T1378 786-787 . denotes .
T1379 787-1029 sentence denotes In contrast, mice with null mutations for the stress-inducible metallothionein genes (Mt1 and Mt2) are viable, though sensitive to cadmium (24,25), indicating that additional important MTF-1 target genes are involved in the lethal phenotype.
T1380 788-790 IN denotes In
T1382 791-799 NN denotes contrast
T1383 799-801 , denotes ,
T1384 801-805 NNS denotes mice
T1385 806-810 IN denotes with
T1386 811-815 JJ denotes null
T1387 816-825 NNS denotes mutations
T1388 826-829 IN denotes for
T1389 830-833 DT denotes the
T1391 834-840 NN denotes stress
T1393 840-841 HYPH denotes -
T1392 841-850 JJ denotes inducible
T1394 851-866 NN denotes metallothionein
T1390 867-872 NNS denotes genes
T1395 873-874 -LRB- denotes (
T1396 874-877 NN denotes Mt1
T1397 878-881 CC denotes and
T1398 882-885 NN denotes Mt2
T1399 885-886 -RRB- denotes )
T1381 887-890 VBP denotes are
T1400 891-897 JJ denotes viable
T1401 897-899 , denotes ,
T1402 899-905 IN denotes though
T1403 906-915 JJ denotes sensitive
T1404 916-918 IN denotes to
T1405 919-926 NN denotes cadmium
T1406 927-928 -LRB- denotes (
T1408 928-930 CD denotes 24
T1409 930-931 , denotes ,
T1407 931-933 CD denotes 25
T1410 933-934 -RRB- denotes )
T1411 934-936 , denotes ,
T1412 936-946 VBG denotes indicating
T1413 947-951 IN denotes that
T1415 952-962 JJ denotes additional
T1417 963-972 JJ denotes important
T1418 973-976 NN denotes MTF
T1419 976-977 HYPH denotes -
T1420 977-978 CD denotes 1
T1421 979-985 NN denotes target
T1416 986-991 NNS denotes genes
T1422 992-995 VBP denotes are
T1414 996-1004 VBN denotes involved
T1423 1005-1007 IN denotes in
T1424 1008-1011 DT denotes the
T1426 1012-1018 JJ denotes lethal
T1425 1019-1028 NN denotes phenotype
T1427 1028-1029 . denotes .
T1428 1029-1175 sentence denotes With the Cre-loxP conditional knockout technique, it is possible to circumvent the embryonic lethal phenotype of conventional Mtf1 knockout mice.
T1429 1030-1034 IN denotes With
T1431 1035-1038 DT denotes the
T1433 1039-1042 NN denotes Cre
T1435 1042-1043 HYPH denotes -
T1434 1043-1047 NN denotes loxP
T1436 1048-1059 JJ denotes conditional
T1437 1060-1068 NN denotes knockout
T1432 1069-1078 NN denotes technique
T1438 1078-1080 , denotes ,
T1439 1080-1082 PRP denotes it
T1430 1083-1085 VBZ denotes is
T1440 1086-1094 JJ denotes possible
T1441 1095-1097 TO denotes to
T1442 1098-1108 VB denotes circumvent
T1443 1109-1112 DT denotes the
T1445 1113-1122 JJ denotes embryonic
T1446 1123-1129 JJ denotes lethal
T1444 1130-1139 NN denotes phenotype
T1447 1140-1142 IN denotes of
T1448 1143-1155 JJ denotes conventional
T1450 1156-1160 NN denotes Mtf1
T1451 1161-1169 NN denotes knockout
T1449 1170-1174 NNS denotes mice
T1452 1174-1175 . denotes .
T1453 1175-1328 sentence denotes Previous experiments with this technique revealed that deletion of Mtf1 from the liver after birth is no longer lethal under non-stress conditions (26).
T1454 1176-1184 JJ denotes Previous
T1455 1185-1196 NNS denotes experiments
T1457 1197-1201 IN denotes with
T1458 1202-1206 DT denotes this
T1459 1207-1216 NN denotes technique
T1456 1217-1225 VBD denotes revealed
T1460 1226-1230 IN denotes that
T1462 1231-1239 NN denotes deletion
T1463 1240-1242 IN denotes of
T1464 1243-1247 NN denotes Mtf1
T1465 1248-1252 IN denotes from
T1466 1253-1256 DT denotes the
T1467 1257-1262 NN denotes liver
T1468 1263-1268 IN denotes after
T1469 1269-1274 NN denotes birth
T1461 1275-1277 VBZ denotes is
T1470 1278-1280 RB denotes no
T1471 1281-1287 RB denotes longer
T1472 1288-1294 JJ denotes lethal
T1473 1295-1300 IN denotes under
T1474 1301-1311 JJ denotes non-stress
T1475 1312-1322 NNS denotes conditions
T1476 1323-1324 -LRB- denotes (
T1477 1324-1326 CD denotes 26
T1478 1326-1327 -RRB- denotes )
T1479 1327-1328 . denotes .
R558 T1215 T1216 det The,role
R559 T1216 T1217 nsubjpass role,studied
R560 T1218 T1216 prep of,role
R561 T1219 T1218 pobj MTF,of
R562 T1220 T1219 punct -,MTF
R563 T1221 T1219 nummod 1,MTF
R564 T1222 T1217 aux has,studied
R565 T1223 T1217 auxpass been,studied
R566 T1224 T1225 advmod most,extensively
R567 T1225 T1217 advmod extensively,studied
R568 T1226 T1217 prep in,studied
R569 T1227 T1228 det the,mouse
R570 T1228 T1226 pobj mouse,in
R571 T1229 T1217 punct .,studied
R572 T1231 T1232 prep Besides,mediate
R573 T1233 T1231 pcomp coping,Besides
R574 T1234 T1233 prep with,coping
R575 T1235 T1236 amod heavy,metal
R576 T1236 T1237 compound metal,load
R577 T1237 T1234 pobj load,with
R578 T1238 T1232 punct ", ",mediate
R579 T1239 T1232 nsubj MTF,mediate
R580 T1240 T1239 punct -,MTF
R581 T1241 T1239 nummod 1,MTF
R582 T1242 T1232 aux can,mediate
R583 T1243 T1232 advmod also,mediate
R584 T1244 T1245 det the,induction
R585 T1245 T1232 dobj induction,mediate
R586 T1246 T1245 prep of,induction
R587 T1247 T1248 compound Mt,genes
R588 T1248 T1246 pobj genes,of
R589 T1249 T1232 prep in,mediate
R590 T1250 T1249 pobj response,in
R591 T1251 T1250 prep to,response
R592 T1252 T1253 amod other,situations
R593 T1253 T1251 pobj situations,to
R594 T1254 T1253 compound stress,situations
R595 T1255 T1253 punct ", ",situations
R596 T1256 T1257 amod such,as
R597 T1257 T1253 prep as,situations
R598 T1258 T1259 amod oxidative,stress
R599 T1259 T1257 pobj stress,as
R600 T1260 T1261 punct (,17
R601 T1261 T1259 parataxis 17,stress
R602 T1262 T1261 nummod 5,17
R603 T1263 T1261 punct ",",17
R604 T1264 T1261 punct ),17
R605 T1265 T1259 cc and,stress
R606 T1266 T1259 conj hypoxia,stress
R607 T1267 T1268 punct (,18
R608 T1268 T1266 parataxis 18,hypoxia
R609 T1269 T1268 punct ),18
R610 T1270 T1232 punct .,mediate
R611 T1272 T1273 prep In,required
R612 T1274 T1272 pobj addition,In
R613 T1275 T1273 punct ", ",required
R614 T1276 T1273 nsubjpass it,required
R615 T1277 T1273 auxpass is,required
R616 T1278 T1273 prep for,required
R617 T1279 T1280 det the,metalloregulation
R618 T1280 T1278 pobj metalloregulation,for
R619 T1281 T1280 prep of,metalloregulation
R620 T1282 T1281 pobj Znt1,of
R621 T1283 T1273 punct ", ",required
R622 T1284 T1273 advcl encoding,required
R623 T1285 T1286 det the,transporter
R624 T1286 T1284 dobj transporter,encoding
R625 T1287 T1286 amod major,transporter
R626 T1288 T1289 compound plasma,membrane
R627 T1289 T1290 npadvmod membrane,localized
R628 T1290 T1286 amod localized,transporter
R629 T1291 T1290 punct -,localized
R630 T1292 T1293 compound zinc,efflux
R631 T1293 T1286 compound efflux,transporter
R632 T1294 T1295 punct (,19
R633 T1295 T1286 parataxis 19,transporter
R634 T1296 T1295 punct ),19
R635 T1297 T1286 punct ", ",transporter
R636 T1298 T1299 det the,induction
R637 T1299 T1286 appos induction,transporter
R638 T1300 T1301 amod hypoxic,anoxic
R639 T1301 T1299 amod anoxic,induction
R640 T1302 T1301 punct /,anoxic
R641 T1303 T1299 prep of,induction
R642 T1304 T1305 det the,gene
R643 T1305 T1303 pobj gene,of
R644 T1306 T1305 prep for,gene
R645 T1307 T1308 amod placental,factor
R646 T1308 T1306 pobj factor,for
R647 T1309 T1308 compound growth,factor
R648 T1310 T1305 punct (,gene
R649 T1311 T1305 appos Plgf,gene
R650 T1312 T1286 punct ),transporter
R651 T1313 T1286 punct ", ",transporter
R652 T1314 T1315 det an,protein
R653 T1315 T1286 appos protein,transporter
R654 T1316 T1315 amod angiogenic,protein
R655 T1317 T1315 prep of,protein
R656 T1318 T1319 det the,family
R657 T1319 T1317 pobj family,of
R658 T1320 T1321 amod vascular,factor
R659 T1321 T1319 nmod factor,family
R660 T1322 T1321 amod endothelial,factor
R661 T1323 T1321 nmod growth,factor
R662 T1324 T1321 punct (,factor
R663 T1325 T1321 appos VEGF,factor
R664 T1326 T1319 punct ),family
R665 T1327 T1328 punct (,20
R666 T1328 T1319 parataxis 20,family
R667 T1329 T1328 punct ),20
R668 T1330 T1273 punct ", ",required
R669 T1331 T1273 cc and,required
R670 T1332 T1333 aux has,invoked
R671 T1333 T1273 conj invoked,required
R672 T1334 T1333 advmod recently,invoked
R673 T1335 T1333 auxpass been,invoked
R674 T1336 T1333 prep in,invoked
R675 T1337 T1338 compound tumor,development
R676 T1338 T1336 pobj development,in
R677 T1339 T1340 punct (,22
R678 T1340 T1333 parataxis 22,invoked
R679 T1341 T1340 nummod 21,22
R680 T1342 T1340 punct ",",22
R681 T1343 T1340 punct ),22
R682 T1344 T1273 punct .,required
R683 T1346 T1347 advmod Furthermore,has
R684 T1347 T1352 ccomp has,results
R685 T1348 T1347 punct ", ",has
R686 T1349 T1347 nsubj MTF,has
R687 T1350 T1349 punct -,MTF
R688 T1351 T1349 nummod 1,MTF
R689 T1353 T1354 det an,function
R690 T1354 T1347 dobj function,has
R691 T1355 T1354 amod essential,function
R692 T1356 T1347 prep during,has
R693 T1357 T1356 pobj embryogenesis,during
R694 T1358 T1352 punct : ,results
R695 T1359 T1360 amod targeted,disruption
R696 T1360 T1352 nsubj disruption,results
R697 T1361 T1360 prep of,disruption
R698 T1362 T1361 pobj Mtf1,of
R699 T1363 T1352 prep in,results
R700 T1364 T1365 amod embryonic,lethality
R701 T1365 T1363 pobj lethality,in
R702 T1366 T1352 prep around,results
R703 T1367 T1368 nummod 14,days
R704 T1368 T1366 pobj days,around
R705 T1369 T1370 advmod post,coitum
R706 T1370 T1368 advmod coitum,days
R707 T1371 T1352 prep due,results
R708 T1372 T1371 pcomp to,due
R709 T1373 T1374 compound hepatocyte,necrosis
R710 T1374 T1371 pobj necrosis,due
R711 T1375 T1376 punct (,23
R712 T1376 T1352 parataxis 23,results
R713 T1377 T1376 punct ),23
R714 T1378 T1352 punct .,results
R715 T1380 T1381 prep In,are
R716 T1382 T1380 pobj contrast,In
R717 T1383 T1381 punct ", ",are
R718 T1384 T1381 nsubj mice,are
R719 T1385 T1384 prep with,mice
R720 T1386 T1387 amod null,mutations
R721 T1387 T1385 pobj mutations,with
R722 T1388 T1387 prep for,mutations
R723 T1389 T1390 det the,genes
R724 T1390 T1388 pobj genes,for
R725 T1391 T1392 npadvmod stress,inducible
R726 T1392 T1390 amod inducible,genes
R727 T1393 T1392 punct -,inducible
R728 T1394 T1390 compound metallothionein,genes
R729 T1395 T1390 punct (,genes
R730 T1396 T1390 appos Mt1,genes
R731 T1397 T1396 cc and,Mt1
R732 T1398 T1396 conj Mt2,Mt1
R733 T1399 T1381 punct ),are
R734 T1400 T1381 acomp viable,are
R735 T1401 T1381 punct ", ",are
R736 T1402 T1403 mark though,sensitive
R737 T1403 T1381 advcl sensitive,are
R738 T1404 T1403 prep to,sensitive
R739 T1405 T1404 pobj cadmium,to
R740 T1406 T1407 punct (,25
R741 T1407 T1403 parataxis 25,sensitive
R742 T1408 T1407 nummod 24,25
R743 T1409 T1407 punct ",",25
R744 T1410 T1407 punct ),25
R745 T1411 T1381 punct ", ",are
R746 T1412 T1381 advcl indicating,are
R747 T1413 T1414 mark that,involved
R748 T1414 T1412 ccomp involved,indicating
R749 T1415 T1416 amod additional,genes
R750 T1416 T1414 nsubjpass genes,involved
R751 T1417 T1416 amod important,genes
R752 T1418 T1416 nmod MTF,genes
R753 T1419 T1418 punct -,MTF
R754 T1420 T1418 nummod 1,MTF
R755 T1421 T1416 compound target,genes
R756 T1422 T1414 auxpass are,involved
R757 T1423 T1414 prep in,involved
R758 T1424 T1425 det the,phenotype
R759 T1425 T1423 pobj phenotype,in
R760 T1426 T1425 amod lethal,phenotype
R761 T1427 T1381 punct .,are
R762 T1429 T1430 prep With,is
R763 T1431 T1432 det the,technique
R764 T1432 T1429 pobj technique,With
R765 T1433 T1434 nmod Cre,loxP
R766 T1434 T1432 nmod loxP,technique
R767 T1435 T1434 punct -,loxP
R768 T1436 T1437 amod conditional,knockout
R769 T1437 T1432 compound knockout,technique
R770 T1438 T1430 punct ", ",is
R771 T1439 T1430 nsubj it,is
R772 T1440 T1430 acomp possible,is
R773 T1441 T1442 aux to,circumvent
R774 T1442 T1430 xcomp circumvent,is
R775 T1443 T1444 det the,phenotype
R776 T1444 T1442 dobj phenotype,circumvent
R777 T1445 T1446 amod embryonic,lethal
R778 T1446 T1444 amod lethal,phenotype
R779 T1447 T1444 prep of,phenotype
R780 T1448 T1449 amod conventional,mice
R781 T1449 T1447 pobj mice,of
R782 T1450 T1451 compound Mtf1,knockout
R783 T1451 T1449 compound knockout,mice
R784 T1452 T1430 punct .,is
R785 T1454 T1455 amod Previous,experiments
R786 T1455 T1456 nsubj experiments,revealed
R787 T1457 T1455 prep with,experiments
R788 T1458 T1459 det this,technique
R789 T1459 T1457 pobj technique,with
R790 T1460 T1461 mark that,is
R791 T1461 T1456 ccomp is,revealed
R792 T1462 T1461 nsubj deletion,is
R793 T1463 T1462 prep of,deletion
R794 T1464 T1463 pobj Mtf1,of
R795 T1465 T1462 prep from,deletion
R796 T1466 T1467 det the,liver
R797 T1467 T1465 pobj liver,from
R798 T1468 T1462 prep after,deletion
R799 T1469 T1468 pobj birth,after
R800 T1470 T1471 neg no,longer
R801 T1471 T1461 advmod longer,is
R802 T1472 T1461 acomp lethal,is
R803 T1473 T1461 prep under,is
R804 T1474 T1475 amod non-stress,conditions
R805 T1475 T1473 pobj conditions,under
R806 T1476 T1477 punct (,26
R807 T1477 T1461 parataxis 26,is
R808 T1478 T1477 punct ),26
R809 T1479 T1456 punct .,revealed