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PMC:1253828 / 26481-27361 JSONTXT 5 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T8229 0-7 JJ denotes Several
T8230 8-13 NNS denotes genes
T8232 14-22 VBN denotes involved
T8233 23-25 IN denotes in
T8234 26-29 DT denotes the
T8235 30-40 NN denotes metabolism
T8236 41-43 IN denotes of
T8237 44-47 DT denotes the
T8239 48-59 NN denotes antioxidant
T8238 60-71 NN denotes glutathione
T8240 72-76 VBD denotes were
T8231 77-82 VBN denotes found
T8241 83-85 TO denotes to
T8243 86-88 VB denotes be
T8242 89-100 VBN denotes upregulated
T8244 101-103 IN denotes by
T8245 104-111 NN denotes cadmium
T8246 112-120 NN denotes exposure
T8247 120-122 , denotes ,
T8248 122-128 RB denotes namely
T8250 129-132 DT denotes the
T8249 133-138 NNS denotes genes
T8251 139-147 VBG denotes encoding
T8252 148-151 DT denotes the
T8254 152-161 JJ denotes catalytic
T8253 162-169 NN denotes subunit
T8255 170-172 IN denotes of
T8256 173-182 NN denotes glutamate
T8258 182-183 HYPH denotes -
T8259 183-191 NN denotes cysteine
T8257 192-198 NN denotes ligase
T8260 199-200 -LRB- denotes (
T8261 200-204 NN denotes Gclc
T8262 204-205 -RRB- denotes )
T8263 206-210 WDT denotes that
T8264 211-213 VBZ denotes is
T8265 214-217 DT denotes the
T8267 218-222 NN denotes rate
T8268 223-231 VBG denotes limiting
T8266 232-238 NN denotes enzyme
T8269 239-241 IN denotes in
T8270 242-244 FW denotes de
T8271 245-249 FW denotes novo
T8272 250-259 NN denotes synthesis
T8273 260-262 IN denotes of
T8274 263-274 NN denotes glutathione
T8275 275-276 -LRB- denotes (
T8276 276-278 CD denotes 45
T8277 278-279 -RRB- denotes )
T8278 279-280 : denotes ;
T8279 281-292 NN denotes glutathione
T8280 293-302 NN denotes reductase
T8281 303-304 CD denotes 1
T8282 305-306 -LRB- denotes (
T8283 306-309 NN denotes Gsr
T8284 309-310 -RRB- denotes )
T8285 310-312 , denotes ,
T8286 312-315 DT denotes the
T8288 316-324 VBG denotes reducing
T8287 325-331 NN denotes enzyme
T8289 332-335 IN denotes for
T8290 336-344 VBN denotes oxidized
T8291 345-356 NN denotes glutathione
T8292 357-358 -LRB- denotes (
T8293 358-360 CD denotes 45
T8294 360-361 -RRB- denotes )
T8295 361-362 : denotes ;
T8296 363-366 CC denotes and
T8297 367-378 NN denotes glutathione
T8299 378-379 HYPH denotes -
T8300 379-380 NN denotes S
T8301 380-381 HYPH denotes -
T8298 381-392 NN denotes transferase
T8302 392-394 , denotes ,
T8303 394-396 NN denotes mu
T8305 397-398 CD denotes 4
T8306 399-400 -LRB- denotes (
T8304 400-405 NN denotes Gstm4
T8307 405-406 -RRB- denotes )
T8308 406-408 , denotes ,
T8309 408-413 WDT denotes which
T8310 414-416 VBZ denotes is
T8311 417-418 DT denotes a
T8312 419-425 NN denotes member
T8313 426-428 IN denotes of
T8314 429-432 DT denotes the
T8316 433-444 NN denotes glutathione
T8318 444-445 HYPH denotes -
T8319 445-446 NN denotes S
T8320 446-447 HYPH denotes -
T8317 447-458 NN denotes transferase
T8321 459-468 NN denotes supergene
T8315 469-475 NN denotes family
T8322 476-478 IN denotes of
T8323 479-493 NN denotes detoxification
T8324 494-501 NNS denotes enzymes
T8325 502-503 -LRB- denotes (
T8326 503-505 CD denotes 45
T8327 505-506 -RRB- denotes )
T8328 506-507 . denotes .
T8329 507-600 sentence denotes In all of these cases, induction was confirmed by semiquantitative RT–PCRs (data not shown).
T8330 508-510 IN denotes In
T8332 511-514 DT denotes all
T8333 515-517 IN denotes of
T8334 518-523 DT denotes these
T8335 524-529 NNS denotes cases
T8336 529-531 , denotes ,
T8337 531-540 NN denotes induction
T8338 541-544 VBD denotes was
T8331 545-554 VBN denotes confirmed
T8339 555-557 IN denotes by
T8340 558-574 JJ denotes semiquantitative
T8342 575-577 NN denotes RT
T8343 577-578 HYPH denotes –
T8341 578-582 NNS denotes PCRs
T8344 583-584 -LRB- denotes (
T8346 584-588 NNS denotes data
T8347 589-592 RB denotes not
T8345 593-598 VBN denotes shown
T8348 598-599 -RRB- denotes )
T8349 599-600 . denotes .
T8350 600-755 sentence denotes Gclc, also referred to as heavy chain subunit of gamma-glutamylcysteine synthetase (Ggcs-hc), had been discussed previously as a target gene of MTF-1 (6).
T8351 601-605 NN denotes Gclc
T8353 605-607 , denotes ,
T8354 607-611 RB denotes also
T8355 612-620 VBN denotes referred
T8356 621-623 IN denotes to
T8357 624-626 IN denotes as
T8358 627-632 JJ denotes heavy
T8359 633-638 NN denotes chain
T8360 639-646 NN denotes subunit
T8361 647-649 IN denotes of
T8362 650-655 NN denotes gamma
T8364 655-656 HYPH denotes -
T8363 656-672 NN denotes glutamylcysteine
T8365 673-683 NN denotes synthetase
T8366 684-685 -LRB- denotes (
T8367 685-689 NN denotes Ggcs
T8369 689-690 HYPH denotes -
T8368 690-692 NN denotes hc
T8370 692-693 -RRB- denotes )
T8371 693-695 , denotes ,
T8372 695-698 VBD denotes had
T8373 699-703 VBN denotes been
T8352 704-713 VBN denotes discussed
T8374 714-724 RB denotes previously
T8375 725-727 IN denotes as
T8376 728-729 DT denotes a
T8378 730-736 NN denotes target
T8377 737-741 NN denotes gene
T8379 742-744 IN denotes of
T8380 745-748 NN denotes MTF
T8381 748-749 HYPH denotes -
T8382 749-750 CD denotes 1
T8383 751-752 -LRB- denotes (
T8384 752-753 CD denotes 6
T8385 753-754 -RRB- denotes )
T8386 754-755 . denotes .
T8387 755-880 sentence denotes Our expression data indicate that Gclc is induced by cadmium but, at least in the adult mouse liver, not dependent on MTF-1.
T8388 756-759 PRP$ denotes Our
T8390 760-770 NN denotes expression
T8389 771-775 NNS denotes data
T8391 776-784 VBP denotes indicate
T8392 785-789 IN denotes that
T8394 790-794 NN denotes Gclc
T8395 795-797 VBZ denotes is
T8393 798-805 VBN denotes induced
T8396 806-808 IN denotes by
T8397 809-816 NN denotes cadmium
T8398 817-820 CC denotes but
T8399 820-822 , denotes ,
T8400 822-824 RB denotes at
T8401 825-830 RBS denotes least
T8402 831-833 IN denotes in
T8404 834-837 DT denotes the
T8406 838-843 JJ denotes adult
T8407 844-849 NN denotes mouse
T8405 850-855 NN denotes liver
T8408 855-857 , denotes ,
T8409 857-860 RB denotes not
T8403 861-870 JJ denotes dependent
T8410 871-873 IN denotes on
T8411 874-877 NN denotes MTF
T8412 877-878 HYPH denotes -
T8413 878-879 CD denotes 1
T8414 879-880 . denotes .
R5145 T8229 T8230 amod Several,genes
R5146 T8230 T8231 nsubjpass genes,found
R5147 T8232 T8230 acl involved,genes
R5148 T8233 T8232 prep in,involved
R5149 T8234 T8235 det the,metabolism
R5150 T8235 T8233 pobj metabolism,in
R5151 T8236 T8235 prep of,metabolism
R5152 T8237 T8238 det the,glutathione
R5153 T8238 T8236 pobj glutathione,of
R5154 T8239 T8238 compound antioxidant,glutathione
R5155 T8240 T8231 auxpass were,found
R5156 T8241 T8242 aux to,upregulated
R5157 T8242 T8231 xcomp upregulated,found
R5158 T8243 T8242 auxpass be,upregulated
R5159 T8244 T8242 agent by,upregulated
R5160 T8245 T8246 compound cadmium,exposure
R5161 T8246 T8244 pobj exposure,by
R5162 T8247 T8242 punct ", ",upregulated
R5163 T8248 T8249 advmod namely,genes
R5164 T8249 T8242 dobj genes,upregulated
R5165 T8250 T8249 det the,genes
R5166 T8251 T8249 acl encoding,genes
R5167 T8252 T8253 det the,subunit
R5168 T8253 T8251 dobj subunit,encoding
R5169 T8254 T8253 amod catalytic,subunit
R5170 T8255 T8253 prep of,subunit
R5171 T8256 T8257 compound glutamate,ligase
R5172 T8257 T8255 pobj ligase,of
R5173 T8258 T8257 punct -,ligase
R5174 T8259 T8257 compound cysteine,ligase
R5175 T8260 T8253 punct (,subunit
R5176 T8261 T8253 appos Gclc,subunit
R5177 T8262 T8253 punct ),subunit
R5178 T8263 T8264 dep that,is
R5179 T8264 T8253 relcl is,subunit
R5180 T8265 T8266 det the,enzyme
R5181 T8266 T8264 attr enzyme,is
R5182 T8267 T8268 npadvmod rate,limiting
R5183 T8268 T8266 amod limiting,enzyme
R5184 T8269 T8266 prep in,enzyme
R5185 T8270 T8271 advmod de,novo
R5186 T8271 T8272 amod novo,synthesis
R5187 T8272 T8269 pobj synthesis,in
R5188 T8273 T8272 prep of,synthesis
R5189 T8274 T8273 pobj glutathione,of
R5190 T8275 T8276 punct (,45
R5191 T8276 T8264 parataxis 45,is
R5192 T8277 T8276 punct ),45
R5193 T8278 T8249 punct ;,genes
R5194 T8279 T8280 compound glutathione,reductase
R5195 T8280 T8249 conj reductase,genes
R5196 T8281 T8280 nummod 1,reductase
R5197 T8282 T8280 punct (,reductase
R5198 T8283 T8280 appos Gsr,reductase
R5199 T8284 T8280 punct ),reductase
R5200 T8285 T8280 punct ", ",reductase
R5201 T8286 T8287 det the,enzyme
R5202 T8287 T8280 appos enzyme,reductase
R5203 T8288 T8287 amod reducing,enzyme
R5204 T8289 T8287 prep for,enzyme
R5205 T8290 T8291 amod oxidized,glutathione
R5206 T8291 T8289 pobj glutathione,for
R5207 T8292 T8293 punct (,45
R5208 T8293 T8291 parataxis 45,glutathione
R5209 T8294 T8293 punct ),45
R5210 T8295 T8280 punct ;,reductase
R5211 T8296 T8280 cc and,reductase
R5212 T8297 T8298 compound glutathione,transferase
R5213 T8298 T8280 conj transferase,reductase
R5214 T8299 T8298 punct -,transferase
R5215 T8300 T8298 compound S,transferase
R5216 T8301 T8298 punct -,transferase
R5217 T8302 T8298 punct ", ",transferase
R5218 T8303 T8304 nmod mu,Gstm4
R5219 T8304 T8298 appos Gstm4,transferase
R5220 T8305 T8304 nummod 4,Gstm4
R5221 T8306 T8304 punct (,Gstm4
R5222 T8307 T8304 punct ),Gstm4
R5223 T8308 T8298 punct ", ",transferase
R5224 T8309 T8310 dep which,is
R5225 T8310 T8298 relcl is,transferase
R5226 T8311 T8312 det a,member
R5227 T8312 T8310 attr member,is
R5228 T8313 T8312 prep of,member
R5229 T8314 T8315 det the,family
R5230 T8315 T8313 pobj family,of
R5231 T8316 T8317 compound glutathione,transferase
R5232 T8317 T8315 compound transferase,family
R5233 T8318 T8317 punct -,transferase
R5234 T8319 T8317 compound S,transferase
R5235 T8320 T8317 punct -,transferase
R5236 T8321 T8315 compound supergene,family
R5237 T8322 T8315 prep of,family
R5238 T8323 T8324 compound detoxification,enzymes
R5239 T8324 T8322 pobj enzymes,of
R5240 T8325 T8326 punct (,45
R5241 T8326 T8312 parataxis 45,member
R5242 T8327 T8326 punct ),45
R5243 T8328 T8231 punct .,found
R5244 T8330 T8331 prep In,confirmed
R5245 T8332 T8330 pobj all,In
R5246 T8333 T8332 prep of,all
R5247 T8334 T8335 det these,cases
R5248 T8335 T8333 pobj cases,of
R5249 T8336 T8331 punct ", ",confirmed
R5250 T8337 T8331 nsubjpass induction,confirmed
R5251 T8338 T8331 auxpass was,confirmed
R5252 T8339 T8331 agent by,confirmed
R5253 T8340 T8341 amod semiquantitative,PCRs
R5254 T8341 T8339 pobj PCRs,by
R5255 T8342 T8341 compound RT,PCRs
R5256 T8343 T8341 punct –,PCRs
R5257 T8344 T8345 punct (,shown
R5258 T8345 T8331 parataxis shown,confirmed
R5259 T8346 T8345 nsubj data,shown
R5260 T8347 T8345 neg not,shown
R5261 T8348 T8345 punct ),shown
R5262 T8349 T8331 punct .,confirmed
R5263 T8351 T8352 nsubjpass Gclc,discussed
R5264 T8353 T8351 punct ", ",Gclc
R5265 T8354 T8355 advmod also,referred
R5266 T8355 T8351 acl referred,Gclc
R5267 T8356 T8355 prep to,referred
R5268 T8357 T8355 prep as,referred
R5269 T8358 T8359 amod heavy,chain
R5270 T8359 T8360 compound chain,subunit
R5271 T8360 T8357 pobj subunit,as
R5272 T8361 T8360 prep of,subunit
R5273 T8362 T8363 compound gamma,glutamylcysteine
R5274 T8363 T8365 compound glutamylcysteine,synthetase
R5275 T8364 T8363 punct -,glutamylcysteine
R5276 T8365 T8361 pobj synthetase,of
R5277 T8366 T8360 punct (,subunit
R5278 T8367 T8368 compound Ggcs,hc
R5279 T8368 T8360 appos hc,subunit
R5280 T8369 T8368 punct -,hc
R5281 T8370 T8352 punct ),discussed
R5282 T8371 T8352 punct ", ",discussed
R5283 T8372 T8352 aux had,discussed
R5284 T8373 T8352 auxpass been,discussed
R5285 T8374 T8352 advmod previously,discussed
R5286 T8375 T8352 prep as,discussed
R5287 T8376 T8377 det a,gene
R5288 T8377 T8375 pobj gene,as
R5289 T8378 T8377 compound target,gene
R5290 T8379 T8377 prep of,gene
R5291 T8380 T8379 pobj MTF,of
R5292 T8381 T8380 punct -,MTF
R5293 T8382 T8380 nummod 1,MTF
R5294 T8383 T8384 punct (,6
R5295 T8384 T8352 parataxis 6,discussed
R5296 T8385 T8384 punct ),6
R5297 T8386 T8352 punct .,discussed
R5298 T8388 T8389 poss Our,data
R5299 T8389 T8391 nsubj data,indicate
R5300 T8390 T8389 compound expression,data
R5301 T8392 T8393 mark that,induced
R5302 T8393 T8391 ccomp induced,indicate
R5303 T8394 T8393 nsubjpass Gclc,induced
R5304 T8395 T8393 auxpass is,induced
R5305 T8396 T8393 agent by,induced
R5306 T8397 T8396 pobj cadmium,by
R5307 T8398 T8393 cc but,induced
R5308 T8399 T8393 punct ", ",induced
R5309 T8400 T8401 advmod at,least
R5310 T8401 T8402 advmod least,in
R5311 T8402 T8403 prep in,dependent
R5312 T8403 T8393 amod dependent,induced
R5313 T8404 T8405 det the,liver
R5314 T8405 T8402 pobj liver,in
R5315 T8406 T8405 amod adult,liver
R5316 T8407 T8405 compound mouse,liver
R5317 T8408 T8403 punct ", ",dependent
R5318 T8409 T8403 neg not,dependent
R5319 T8410 T8403 prep on,dependent
R5320 T8411 T8410 pobj MTF,on
R5321 T8412 T8411 punct -,MTF
R5322 T8413 T8411 nummod 1,MTF
R5323 T8414 T8391 punct .,indicate