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PMC:1253828 / 23120-24177 JSONTXT 5 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function

Id Subject Object Predicate Lexical cue
T6936 0-7 NN denotes Cadmium
T6937 8-16 NN denotes response
T6939 17-19 IN denotes of
T6940 20-25 NN denotes Csrp1
T6938 26-33 VBZ denotes depends
T6941 34-36 IN denotes on
T6942 37-40 NN denotes MTF
T6943 40-41 HYPH denotes -
T6944 41-42 CD denotes 1
T6945 42-190 sentence denotes Csrp1 was found in microarray analyses to be significantly downregulated in cadmium-treated Mtf1Mx-cre mice compared to Mtf1loxP mice (Table 1, c).
T6946 43-48 NN denotes Csrp1
T6948 49-52 VBD denotes was
T6947 53-58 VBN denotes found
T6949 59-61 IN denotes in
T6950 62-72 NN denotes microarray
T6951 73-81 NNS denotes analyses
T6952 82-84 TO denotes to
T6954 85-87 VB denotes be
T6955 88-101 RB denotes significantly
T6953 102-115 VBN denotes downregulated
T6956 116-118 IN denotes in
T6957 119-126 NN denotes cadmium
T6959 126-127 HYPH denotes -
T6958 127-134 VBN denotes treated
T6961 135-141 NN denotes Mtf1Mx
T6934 141-142 HYPH denotes -
T6962 142-145 NN denotes cre
T6960 146-150 NNS denotes mice
T6963 151-159 VBN denotes compared
T6964 160-162 IN denotes to
T6965 163-171 NN denotes Mtf1loxP
T6966 172-176 NNS denotes mice
T6967 177-178 -LRB- denotes (
T6969 178-183 NN denotes Table
T6970 184-185 CD denotes 1
T6971 185-187 , denotes ,
T6968 187-188 NN denotes c
T6972 188-189 -RRB- denotes )
T6973 189-190 . denotes .
T6974 190-338 sentence denotes CSRP1 is a member of the evolutionary conserved CRP family of proteins that have been implicated in myogenesis and cytoskeletal remodeling (41,42).
T6975 191-196 NN denotes CSRP1
T6976 197-199 VBZ denotes is
T6977 200-201 DT denotes a
T6978 202-208 NN denotes member
T6979 209-211 IN denotes of
T6980 212-215 DT denotes the
T6982 216-228 JJ denotes evolutionary
T6983 229-238 VBN denotes conserved
T6984 239-242 NN denotes CRP
T6981 243-249 NN denotes family
T6985 250-252 IN denotes of
T6935 253-261 NN denotes proteins
T6986 262-266 WDT denotes that
T6988 267-271 VBP denotes have
T6989 272-276 VBN denotes been
T6987 277-287 VBN denotes implicated
T6990 288-290 IN denotes in
T6991 291-301 NN denotes myogenesis
T6992 302-305 CC denotes and
T6993 306-318 JJ denotes cytoskeletal
T6994 319-329 NN denotes remodeling
T6995 330-331 -LRB- denotes (
T6997 331-333 CD denotes 41
T6998 333-334 , denotes ,
T6996 334-336 CD denotes 42
T6999 336-337 -RRB- denotes )
T7000 337-338 . denotes .
T7001 338-493 sentence denotes Semiquantitative RT–PCRs confirmed the microarray results, namely, that Csrp1 expression is elevated in Mtf1loxP livers upon cadmium exposure (Figure 4a).
T7002 339-355 JJ denotes Semiquantitative
T7004 356-358 NN denotes RT
T7005 358-359 HYPH denotes –
T7003 359-363 NNS denotes PCRs
T7006 364-373 VBD denotes confirmed
T7007 374-377 DT denotes the
T7008 378-388 NN denotes microarray
T7009 389-396 VBZ denotes results
T7010 396-398 , denotes ,
T7011 398-404 RB denotes namely
T7013 404-406 , denotes ,
T7014 406-410 IN denotes that
T7015 411-416 NN denotes Csrp1
T7016 417-427 NN denotes expression
T7017 428-430 VBZ denotes is
T7012 431-439 VBN denotes elevated
T7018 440-442 IN denotes in
T7019 443-451 NN denotes Mtf1loxP
T7020 452-458 NNS denotes livers
T7021 459-463 IN denotes upon
T7022 464-471 NN denotes cadmium
T7023 472-480 NN denotes exposure
T7024 481-482 -LRB- denotes (
T7026 482-488 NN denotes Figure
T7025 489-491 NN denotes 4a
T7027 491-492 -RRB- denotes )
T7028 492-493 . denotes .
T7029 493-639 sentence denotes In contrast, no cadmium response was detectable in livers from Mtf1Mx-cre mice, suggesting that MTF-1 is required for cadmium induction of Csrp1.
T7030 494-496 IN denotes In
T7032 497-505 NN denotes contrast
T7033 505-507 , denotes ,
T7034 507-509 DT denotes no
T7036 510-517 NN denotes cadmium
T7035 518-526 NN denotes response
T7031 527-530 VBD denotes was
T7037 531-541 JJ denotes detectable
T7038 542-544 IN denotes in
T7039 545-551 NNS denotes livers
T7040 552-556 IN denotes from
T7041 557-563 NN denotes Mtf1Mx
T7043 563-564 HYPH denotes -
T7042 564-567 NN denotes cre
T7044 568-572 NNS denotes mice
T7045 572-574 , denotes ,
T7046 574-584 VBG denotes suggesting
T7047 585-589 IN denotes that
T7049 590-593 NN denotes MTF
T7050 593-594 HYPH denotes -
T7051 594-595 CD denotes 1
T7052 596-598 VBZ denotes is
T7048 599-607 VBN denotes required
T7053 608-611 IN denotes for
T7054 612-619 NN denotes cadmium
T7055 620-629 NN denotes induction
T7056 630-632 IN denotes of
T7057 633-638 NN denotes Csrp1
T7058 638-639 . denotes .
T7059 639-822 sentence denotes Three MRE core consensus sequences were found upstream of the Csrp1 transcription start (MRE2 to MRE4, −56 to −366 bp), one was found immediately downstream (MRE1, +7 bp; Figure 4b).
T7060 640-645 CD denotes Three
T7062 646-649 NN denotes MRE
T7063 650-654 NN denotes core
T7064 655-664 NN denotes consensus
T7061 665-674 NNS denotes sequences
T7066 675-679 VBD denotes were
T7065 680-685 VBN denotes found
T7068 686-694 RB denotes upstream
T7069 695-697 IN denotes of
T7070 698-701 DT denotes the
T7072 702-707 NN denotes Csrp1
T7073 708-721 NN denotes transcription
T7071 722-727 NN denotes start
T7074 728-729 -LRB- denotes (
T7076 729-733 NN denotes MRE2
T7077 734-736 IN denotes to
T7078 737-741 NN denotes MRE4
T7079 741-743 , denotes ,
T7080 743-744 SYM denotes −
T7081 744-746 CD denotes 56
T7083 747-749 IN denotes to
T7084 750-751 SYM denotes −
T7082 751-754 CD denotes 366
T7075 755-757 NN denotes bp
T7085 757-758 -RRB- denotes )
T7086 758-760 , denotes ,
T7087 760-763 CD denotes one
T7088 764-767 VBD denotes was
T7067 768-773 VBN denotes found
T7089 774-785 RB denotes immediately
T7090 786-796 RB denotes downstream
T7091 797-798 -LRB- denotes (
T7093 798-802 NN denotes MRE1
T7094 802-804 , denotes ,
T7095 804-805 SYM denotes +
T7096 805-806 CD denotes 7
T7097 807-809 NN denotes bp
T7098 809-810 : denotes ;
T7099 811-817 NN denotes Figure
T7092 818-820 NN denotes 4b
T7100 820-821 -RRB- denotes )
T7101 821-822 . denotes .
T7102 822-1057 sentence denotes Specific binding of MTF-1 was observed with EMSA for MRE2 oligonucleotide and protein extract from an Mtf1loxP liver, but not an Mtf1Mx-cre liver extract lacking MTF-1, confirming the participation of MTF-1 in the complex (Figure 4c).
T7103 823-831 JJ denotes Specific
T7104 832-839 NN denotes binding
T7106 840-842 IN denotes of
T7107 843-846 NN denotes MTF
T7108 846-847 HYPH denotes -
T7109 847-848 CD denotes 1
T7110 849-852 VBD denotes was
T7105 853-861 VBN denotes observed
T7111 862-866 IN denotes with
T7112 867-871 NN denotes EMSA
T7113 872-875 IN denotes for
T7114 876-880 NN denotes MRE2
T7115 881-896 NN denotes oligonucleotide
T7116 897-900 CC denotes and
T7117 901-908 NN denotes protein
T7118 909-916 NN denotes extract
T7119 917-921 IN denotes from
T7120 922-924 DT denotes an
T7122 925-933 NN denotes Mtf1loxP
T7121 934-939 NN denotes liver
T7124 939-941 , denotes ,
T7125 941-944 CC denotes but
T7126 945-948 RB denotes not
T7127 949-951 DT denotes an
T7129 952-958 NN denotes Mtf1Mx
T7131 958-959 HYPH denotes -
T7130 959-962 NN denotes cre
T7128 963-968 NN denotes liver
T7123 969-976 NN denotes extract
T7132 977-984 VBG denotes lacking
T7133 985-988 NN denotes MTF
T7134 988-989 HYPH denotes -
T7135 989-990 CD denotes 1
T7136 990-992 , denotes ,
T7137 992-1002 VBG denotes confirming
T7138 1003-1006 DT denotes the
T7139 1007-1020 NN denotes participation
T7140 1021-1023 IN denotes of
T7141 1024-1027 NN denotes MTF
T7142 1027-1028 HYPH denotes -
T7143 1028-1029 CD denotes 1
T7144 1030-1032 IN denotes in
T7145 1033-1036 DT denotes the
T7146 1037-1044 NN denotes complex
T7147 1045-1046 -LRB- denotes (
T7149 1046-1052 NN denotes Figure
T7148 1053-1055 NN denotes 4c
T7150 1055-1056 -RRB- denotes )
T7151 1056-1057 . denotes .
R4499 T6934 T6962 punct -,cre
R4500 T6935 T6985 pobj proteins,of
R4501 T6936 T6937 compound Cadmium,response
R4502 T6937 T6938 nsubj response,depends
R4503 T6939 T6937 prep of,response
R4504 T6940 T6939 pobj Csrp1,of
R4505 T6941 T6938 prep on,depends
R4506 T6942 T6941 pobj MTF,on
R4507 T6943 T6942 punct -,MTF
R4508 T6944 T6942 nummod 1,MTF
R4509 T6946 T6947 nsubjpass Csrp1,found
R4510 T6948 T6947 auxpass was,found
R4511 T6949 T6947 prep in,found
R4512 T6950 T6951 compound microarray,analyses
R4513 T6951 T6949 pobj analyses,in
R4514 T6952 T6953 aux to,downregulated
R4515 T6953 T6947 xcomp downregulated,found
R4516 T6954 T6953 auxpass be,downregulated
R4517 T6955 T6953 advmod significantly,downregulated
R4518 T6956 T6953 prep in,downregulated
R4519 T6957 T6958 npadvmod cadmium,treated
R4520 T6958 T6960 amod treated,mice
R4521 T6959 T6958 punct -,treated
R4522 T6960 T6956 pobj mice,in
R4523 T6961 T6962 compound Mtf1Mx,cre
R4524 T6962 T6960 compound cre,mice
R4525 T6963 T6953 prep compared,downregulated
R4526 T6964 T6963 prep to,compared
R4527 T6965 T6966 compound Mtf1loxP,mice
R4528 T6966 T6964 pobj mice,to
R4529 T6967 T6968 punct (,c
R4530 T6968 T6953 parataxis c,downregulated
R4531 T6969 T6968 nmod Table,c
R4532 T6970 T6968 nummod 1,c
R4533 T6971 T6968 punct ", ",c
R4534 T6972 T6968 punct ),c
R4535 T6973 T6947 punct .,found
R4536 T6975 T6976 nsubj CSRP1,is
R4537 T6977 T6978 det a,member
R4538 T6978 T6976 attr member,is
R4539 T6979 T6978 prep of,member
R4540 T6980 T6981 det the,family
R4541 T6981 T6979 pobj family,of
R4542 T6982 T6983 amod evolutionary,conserved
R4543 T6983 T6981 amod conserved,family
R4544 T6984 T6981 compound CRP,family
R4545 T6985 T6981 prep of,family
R4546 T6986 T6987 dep that,implicated
R4547 T6987 T6935 relcl implicated,proteins
R4548 T6988 T6987 aux have,implicated
R4549 T6989 T6987 auxpass been,implicated
R4550 T6990 T6987 prep in,implicated
R4551 T6991 T6990 pobj myogenesis,in
R4552 T6992 T6991 cc and,myogenesis
R4553 T6993 T6994 amod cytoskeletal,remodeling
R4554 T6994 T6991 conj remodeling,myogenesis
R4555 T6995 T6996 punct (,42
R4556 T6996 T6987 parataxis 42,implicated
R4557 T6997 T6996 nummod 41,42
R4558 T6998 T6996 punct ",",42
R4559 T6999 T6996 punct ),42
R4560 T7000 T6976 punct .,is
R4561 T7002 T7003 amod Semiquantitative,PCRs
R4562 T7003 T7006 nsubj PCRs,confirmed
R4563 T7004 T7003 compound RT,PCRs
R4564 T7005 T7003 punct –,PCRs
R4565 T7007 T7008 det the,microarray
R4566 T7008 T7006 dobj microarray,confirmed
R4567 T7009 T7008 nmod results,microarray
R4568 T7010 T7008 punct ", ",microarray
R4569 T7011 T7012 advmod namely,elevated
R4570 T7012 T7008 acl elevated,microarray
R4571 T7013 T7012 punct ", ",elevated
R4572 T7014 T7012 mark that,elevated
R4573 T7015 T7016 compound Csrp1,expression
R4574 T7016 T7012 nsubjpass expression,elevated
R4575 T7017 T7012 auxpass is,elevated
R4576 T7018 T7012 prep in,elevated
R4577 T7019 T7020 compound Mtf1loxP,livers
R4578 T7020 T7018 pobj livers,in
R4579 T7021 T7012 prep upon,elevated
R4580 T7022 T7023 compound cadmium,exposure
R4581 T7023 T7021 pobj exposure,upon
R4582 T7024 T7025 punct (,4a
R4583 T7025 T7012 parataxis 4a,elevated
R4584 T7026 T7025 compound Figure,4a
R4585 T7027 T7025 punct ),4a
R4586 T7028 T7006 punct .,confirmed
R4587 T7030 T7031 prep In,was
R4588 T7032 T7030 pobj contrast,In
R4589 T7033 T7031 punct ", ",was
R4590 T7034 T7035 det no,response
R4591 T7035 T7031 nsubj response,was
R4592 T7036 T7035 compound cadmium,response
R4593 T7037 T7031 acomp detectable,was
R4594 T7038 T7031 prep in,was
R4595 T7039 T7038 pobj livers,in
R4596 T7040 T7039 prep from,livers
R4597 T7041 T7042 compound Mtf1Mx,cre
R4598 T7042 T7044 compound cre,mice
R4599 T7043 T7042 punct -,cre
R4600 T7044 T7040 pobj mice,from
R4601 T7045 T7031 punct ", ",was
R4602 T7046 T7031 advcl suggesting,was
R4603 T7047 T7048 mark that,required
R4604 T7048 T7046 ccomp required,suggesting
R4605 T7049 T7048 nsubjpass MTF,required
R4606 T7050 T7049 punct -,MTF
R4607 T7051 T7049 nummod 1,MTF
R4608 T7052 T7048 auxpass is,required
R4609 T7053 T7048 prep for,required
R4610 T7054 T7055 compound cadmium,induction
R4611 T7055 T7053 pobj induction,for
R4612 T7056 T7055 prep of,induction
R4613 T7057 T7056 pobj Csrp1,of
R4614 T7058 T7031 punct .,was
R4615 T7060 T7061 nummod Three,sequences
R4616 T7061 T7065 nsubjpass sequences,found
R4617 T7062 T7061 compound MRE,sequences
R4618 T7063 T7064 compound core,consensus
R4619 T7064 T7061 compound consensus,sequences
R4620 T7065 T7067 ccomp found,found
R4621 T7066 T7065 auxpass were,found
R4622 T7068 T7065 advmod upstream,found
R4623 T7069 T7068 prep of,upstream
R4624 T7070 T7071 det the,start
R4625 T7071 T7069 pobj start,of
R4626 T7072 T7073 compound Csrp1,transcription
R4627 T7073 T7071 compound transcription,start
R4628 T7074 T7075 punct (,bp
R4629 T7075 T7071 parataxis bp,start
R4630 T7076 T7075 dep MRE2,bp
R4631 T7077 T7076 prep to,MRE2
R4632 T7078 T7077 pobj MRE4,to
R4633 T7079 T7075 punct ", ",bp
R4634 T7080 T7081 punct −,56
R4635 T7081 T7082 quantmod 56,366
R4636 T7082 T7075 nummod 366,bp
R4637 T7083 T7082 quantmod to,366
R4638 T7084 T7082 punct −,366
R4639 T7085 T7075 punct ),bp
R4640 T7086 T7067 punct ", ",found
R4641 T7087 T7067 nsubjpass one,found
R4642 T7088 T7067 auxpass was,found
R4643 T7089 T7090 advmod immediately,downstream
R4644 T7090 T7067 advmod downstream,found
R4645 T7091 T7092 punct (,4b
R4646 T7092 T7067 parataxis 4b,found
R4647 T7093 T7092 dep MRE1,4b
R4648 T7094 T7093 punct ", ",MRE1
R4649 T7095 T7096 punct +,7
R4650 T7096 T7097 nummod 7,bp
R4651 T7097 T7093 appos bp,MRE1
R4652 T7098 T7092 punct ;,4b
R4653 T7099 T7092 compound Figure,4b
R4654 T7100 T7092 punct ),4b
R4655 T7101 T7067 punct .,found
R4656 T7103 T7104 amod Specific,binding
R4657 T7104 T7105 nsubjpass binding,observed
R4658 T7106 T7104 prep of,binding
R4659 T7107 T7106 pobj MTF,of
R4660 T7108 T7107 punct -,MTF
R4661 T7109 T7107 nummod 1,MTF
R4662 T7110 T7105 auxpass was,observed
R4663 T7111 T7105 prep with,observed
R4664 T7112 T7111 pobj EMSA,with
R4665 T7113 T7112 prep for,EMSA
R4666 T7114 T7115 compound MRE2,oligonucleotide
R4667 T7115 T7113 pobj oligonucleotide,for
R4668 T7116 T7115 cc and,oligonucleotide
R4669 T7117 T7118 compound protein,extract
R4670 T7118 T7115 conj extract,oligonucleotide
R4671 T7119 T7118 prep from,extract
R4672 T7120 T7121 det an,liver
R4673 T7121 T7123 nmod liver,extract
R4674 T7122 T7121 nmod Mtf1loxP,liver
R4675 T7123 T7119 pobj extract,from
R4676 T7124 T7121 punct ", ",liver
R4677 T7125 T7121 cc but,liver
R4678 T7126 T7125 neg not,but
R4679 T7127 T7128 det an,liver
R4680 T7128 T7121 conj liver,liver
R4681 T7129 T7130 compound Mtf1Mx,cre
R4682 T7130 T7128 compound cre,liver
R4683 T7131 T7130 punct -,cre
R4684 T7132 T7123 acl lacking,extract
R4685 T7133 T7132 dobj MTF,lacking
R4686 T7134 T7133 punct -,MTF
R4687 T7135 T7133 nummod 1,MTF
R4688 T7136 T7105 punct ", ",observed
R4689 T7137 T7105 advcl confirming,observed
R4690 T7138 T7139 det the,participation
R4691 T7139 T7137 dobj participation,confirming
R4692 T7140 T7139 prep of,participation
R4693 T7141 T7140 pobj MTF,of
R4694 T7142 T7141 punct -,MTF
R4695 T7143 T7141 nummod 1,MTF
R4696 T7144 T7139 prep in,participation
R4697 T7145 T7146 det the,complex
R4698 T7146 T7144 pobj complex,in
R4699 T7147 T7148 punct (,4c
R4700 T7148 T7137 parataxis 4c,confirming
R4701 T7149 T7148 compound Figure,4c
R4702 T7150 T7148 punct ),4c
R4703 T7151 T7105 punct .,observed