PMC:1208879 / 1129-1516 4 Projects
Annnotations
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T384 | 0-10 | NN | denotes | Conclusion |
| T385 | 10-90 | sentence | denotes | Our preliminary data suggest that PAX6 interacts with HOMER3, DNCL1 and TRIM11. |
| T386 | 11-14 | PRP$ | denotes | Our |
| T388 | 15-26 | JJ | denotes | preliminary |
| T387 | 27-31 | NNS | denotes | data |
| T389 | 32-39 | VBP | denotes | suggest |
| T390 | 40-44 | IN | denotes | that |
| T392 | 45-49 | NN | denotes | PAX6 |
| T391 | 50-59 | VBZ | denotes | interacts |
| T393 | 60-64 | IN | denotes | with |
| T394 | 65-71 | NN | denotes | HOMER3 |
| T395 | 71-73 | , | denotes | , |
| T396 | 73-78 | NN | denotes | DNCL1 |
| T397 | 79-82 | CC | denotes | and |
| T398 | 83-89 | NN | denotes | TRIM11 |
| T399 | 89-90 | . | denotes | . |
| T400 | 90-387 | sentence | denotes | We propose that the interaction of PAX6 with HOMER3 and DNCL1 is a mechanism by which synaptic activation could lead to changes in neuronal transcriptional activity, and that some of the neural anomalies in patients with PAX6 mutations could be explained by impaired protein-protein interactions. |
| T401 | 91-93 | PRP | denotes | We |
| T402 | 94-101 | VBP | denotes | propose |
| T403 | 102-106 | IN | denotes | that |
| T405 | 107-110 | DT | denotes | the |
| T406 | 111-122 | NN | denotes | interaction |
| T407 | 123-125 | IN | denotes | of |
| T408 | 126-130 | NN | denotes | PAX6 |
| T409 | 131-135 | IN | denotes | with |
| T410 | 136-142 | NN | denotes | HOMER3 |
| T411 | 143-146 | CC | denotes | and |
| T412 | 147-152 | NN | denotes | DNCL1 |
| T404 | 153-155 | VBZ | denotes | is |
| T413 | 156-157 | DT | denotes | a |
| T414 | 158-167 | NN | denotes | mechanism |
| T415 | 168-170 | IN | denotes | by |
| T417 | 171-176 | WDT | denotes | which |
| T418 | 177-185 | JJ | denotes | synaptic |
| T419 | 186-196 | NN | denotes | activation |
| T420 | 197-202 | MD | denotes | could |
| T416 | 203-207 | VB | denotes | lead |
| T421 | 208-210 | IN | denotes | to |
| T422 | 211-218 | NNS | denotes | changes |
| T423 | 219-221 | IN | denotes | in |
| T424 | 222-230 | JJ | denotes | neuronal |
| T426 | 231-246 | JJ | denotes | transcriptional |
| T425 | 247-255 | NN | denotes | activity |
| T427 | 255-257 | , | denotes | , |
| T428 | 257-260 | CC | denotes | and |
| T429 | 261-265 | IN | denotes | that |
| T431 | 266-270 | DT | denotes | some |
| T432 | 271-273 | IN | denotes | of |
| T433 | 274-277 | DT | denotes | the |
| T435 | 278-284 | JJ | denotes | neural |
| T434 | 285-294 | NNS | denotes | anomalies |
| T436 | 295-297 | IN | denotes | in |
| T437 | 298-306 | NNS | denotes | patients |
| T438 | 307-311 | IN | denotes | with |
| T439 | 312-316 | NN | denotes | PAX6 |
| T440 | 317-326 | NNS | denotes | mutations |
| T441 | 327-332 | MD | denotes | could |
| T442 | 333-335 | VB | denotes | be |
| T430 | 336-345 | VBN | denotes | explained |
| T443 | 346-348 | IN | denotes | by |
| T444 | 349-357 | JJ | denotes | impaired |
| T446 | 358-365 | NN | denotes | protein |
| T448 | 365-366 | SYM | denotes | - |
| T447 | 366-373 | NN | denotes | protein |
| T445 | 374-386 | NNS | denotes | interactions |
| T449 | 386-387 | . | denotes | . |
| R188 | T386 | T387 | poss | Our,data |
| R189 | T387 | T389 | nsubj | data,suggest |
| R190 | T388 | T387 | amod | preliminary,data |
| R191 | T390 | T391 | mark | that,interacts |
| R192 | T391 | T389 | ccomp | interacts,suggest |
| R193 | T392 | T391 | nsubj | PAX6,interacts |
| R194 | T393 | T391 | prep | with,interacts |
| R195 | T394 | T393 | pobj | HOMER3,with |
| R196 | T395 | T394 | punct | ", ",HOMER3 |
| R197 | T396 | T394 | conj | DNCL1,HOMER3 |
| R198 | T397 | T396 | cc | and,DNCL1 |
| R199 | T398 | T396 | conj | TRIM11,DNCL1 |
| R200 | T399 | T389 | punct | .,suggest |
| R201 | T401 | T402 | nsubj | We,propose |
| R202 | T403 | T404 | mark | that,is |
| R203 | T404 | T402 | advcl | is,propose |
| R204 | T405 | T406 | det | the,interaction |
| R205 | T406 | T404 | nsubj | interaction,is |
| R206 | T407 | T406 | prep | of,interaction |
| R207 | T408 | T407 | pobj | PAX6,of |
| R208 | T409 | T406 | prep | with,interaction |
| R209 | T410 | T409 | pobj | HOMER3,with |
| R210 | T411 | T410 | cc | and,HOMER3 |
| R211 | T412 | T410 | conj | DNCL1,HOMER3 |
| R212 | T413 | T414 | det | a,mechanism |
| R213 | T414 | T404 | attr | mechanism,is |
| R214 | T415 | T416 | prep | by,lead |
| R215 | T416 | T414 | relcl | lead,mechanism |
| R216 | T417 | T415 | pobj | which,by |
| R217 | T418 | T419 | amod | synaptic,activation |
| R218 | T419 | T416 | nsubj | activation,lead |
| R219 | T420 | T416 | aux | could,lead |
| R220 | T421 | T416 | prep | to,lead |
| R221 | T422 | T421 | pobj | changes,to |
| R222 | T423 | T422 | prep | in,changes |
| R223 | T424 | T425 | amod | neuronal,activity |
| R224 | T425 | T423 | pobj | activity,in |
| R225 | T426 | T425 | amod | transcriptional,activity |
| R226 | T427 | T404 | punct | ", ",is |
| R227 | T428 | T404 | cc | and,is |
| R228 | T429 | T430 | mark | that,explained |
| R229 | T430 | T404 | conj | explained,is |
| R230 | T431 | T430 | nsubjpass | some,explained |
| R231 | T432 | T431 | prep | of,some |
| R232 | T433 | T434 | det | the,anomalies |
| R233 | T434 | T432 | pobj | anomalies,of |
| R234 | T435 | T434 | amod | neural,anomalies |
| R235 | T436 | T434 | prep | in,anomalies |
| R236 | T437 | T436 | pobj | patients,in |
| R237 | T438 | T437 | prep | with,patients |
| R238 | T439 | T440 | compound | PAX6,mutations |
| R239 | T440 | T438 | pobj | mutations,with |
| R240 | T441 | T430 | aux | could,explained |
| R241 | T442 | T430 | auxpass | be,explained |
| R242 | T443 | T430 | prep | by,explained |
| R243 | T444 | T445 | amod | impaired,interactions |
| R244 | T445 | T443 | pobj | interactions,by |
| R245 | T446 | T447 | nmod | protein,protein |
| R246 | T447 | T445 | compound | protein,interactions |
| R247 | T448 | T447 | punct | -,protein |
| R248 | T449 | T402 | punct | .,propose |