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PMC:1208873 / 3618-4266 JSONTXT 4 Projects

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Id Subject Object Predicate Lexical cue
T1178 0-9 RB denotes Therefore
T1180 9-11 , denotes ,
T1181 11-13 PRP denotes we
T1182 13-15 , denotes ,
T1183 15-18 CC denotes and
T1184 19-25 NNS denotes others
T1185 25-27 , denotes ,
T1179 27-30 VBN denotes set
T1186 31-34 RP denotes out
T1187 35-37 TO denotes to
T1188 38-46 VB denotes discover
T1189 47-57 NN denotes huntingtin
T1191 57-59 POS denotes 's
T1192 60-69 JJ denotes essential
T1190 70-80 NNS denotes activities
T1193 81-83 IN denotes by
T1194 84-92 VBG denotes studying
T1195 93-96 DT denotes the
T1196 97-104 NNS denotes effects
T1197 105-107 IN denotes of
T1198 108-118 NN denotes huntingtin
T1199 119-129 NN denotes deficiency
T1200 130-132 IN denotes in
T1201 133-136 DT denotes the
T1202 137-142 NN denotes mouse
T1203 142-143 . denotes .
T1204 143-346 sentence denotes Inactivation of the mouse HD gene (Hdh) has shown that huntingtin is not required for cell viability, as evidenced by the survival of mouse embryonic stem cells and neurons that lack huntingtin [10-12].
T1205 144-156 NN denotes Inactivation
T1207 157-159 IN denotes of
T1208 160-163 DT denotes the
T1210 164-169 NN denotes mouse
T1211 170-172 NN denotes HD
T1209 173-177 NN denotes gene
T1212 178-179 -LRB- denotes (
T1213 179-182 NN denotes Hdh
T1214 182-183 -RRB- denotes )
T1215 184-187 VBZ denotes has
T1206 188-193 VBN denotes shown
T1216 194-198 IN denotes that
T1218 199-209 NN denotes huntingtin
T1219 210-212 VBZ denotes is
T1220 213-216 RB denotes not
T1217 217-225 VBN denotes required
T1221 226-229 IN denotes for
T1222 230-234 NN denotes cell
T1223 235-244 NN denotes viability
T1224 244-246 , denotes ,
T1225 246-248 IN denotes as
T1226 249-258 VBN denotes evidenced
T1227 259-261 IN denotes by
T1228 262-265 DT denotes the
T1229 266-274 NN denotes survival
T1230 275-277 IN denotes of
T1231 278-283 NN denotes mouse
T1233 284-293 JJ denotes embryonic
T1234 294-298 NN denotes stem
T1232 299-304 NNS denotes cells
T1235 305-308 CC denotes and
T1236 309-316 NNS denotes neurons
T1237 317-321 WDT denotes that
T1238 322-326 VBP denotes lack
T1239 327-337 NN denotes huntingtin
T1240 338-339 -LRB- denotes [
T1241 339-341 CD denotes 10
T1242 341-342 SYM denotes -
T1243 342-344 CD denotes 12
T1244 344-345 -RRB- denotes ]
T1245 345-346 . denotes .
T1246 346-460 sentence denotes However, huntingtin is needed at the level of the organism for proper mammalian embryonic development [10,13,14].
T1247 347-354 RB denotes However
T1249 354-356 , denotes ,
T1250 356-366 NN denotes huntingtin
T1251 367-369 VBZ denotes is
T1248 370-376 VBN denotes needed
T1252 377-379 IN denotes at
T1253 380-383 DT denotes the
T1254 384-389 NN denotes level
T1255 390-392 IN denotes of
T1256 393-396 DT denotes the
T1257 397-405 NN denotes organism
T1258 406-409 IN denotes for
T1259 410-416 JJ denotes proper
T1261 417-426 JJ denotes mammalian
T1262 427-436 JJ denotes embryonic
T1260 437-448 NN denotes development
T1263 449-450 -LRB- denotes [
T1265 450-452 CD denotes 10
T1266 452-453 , denotes ,
T1267 453-455 CD denotes 13
T1268 455-456 , denotes ,
T1264 456-458 CD denotes 14
T1269 458-459 -RRB- denotes ]
T1270 459-460 . denotes .
T1271 460-648 sentence denotes Complete lack of huntingtin results in developmental arrest during gastrulation, while severe reduction of huntingtin levels results in abnormal neurogenesis and perinatal lethality [15].
T1272 461-469 JJ denotes Complete
T1273 470-474 NN denotes lack
T1275 475-477 IN denotes of
T1276 478-488 NN denotes huntingtin
T1274 489-496 VBZ denotes results
T1277 497-499 IN denotes in
T1278 500-513 JJ denotes developmental
T1279 514-520 NN denotes arrest
T1280 521-527 IN denotes during
T1281 528-540 NN denotes gastrulation
T1282 540-542 , denotes ,
T1283 542-547 IN denotes while
T1285 548-554 JJ denotes severe
T1286 555-564 NN denotes reduction
T1287 565-567 IN denotes of
T1288 568-578 NN denotes huntingtin
T1289 579-585 NNS denotes levels
T1284 586-593 VBZ denotes results
T1290 594-596 IN denotes in
T1291 597-605 JJ denotes abnormal
T1292 606-618 NN denotes neurogenesis
T1293 619-622 CC denotes and
T1294 623-632 JJ denotes perinatal
T1295 633-642 NN denotes lethality
T1296 643-644 -LRB- denotes [
T1297 644-646 CD denotes 15
T1298 646-647 -RRB- denotes ]
T1299 647-648 . denotes .
R574 T1178 T1179 advmod Therefore,set
R575 T1180 T1179 punct ", ",set
R576 T1181 T1179 nsubj we,set
R577 T1182 T1181 punct ", ",we
R578 T1183 T1181 cc and,we
R579 T1184 T1181 conj others,we
R580 T1185 T1179 punct ", ",set
R581 T1186 T1179 prt out,set
R582 T1187 T1188 aux to,discover
R583 T1188 T1179 xcomp discover,set
R584 T1189 T1190 poss huntingtin,activities
R585 T1190 T1188 dobj activities,discover
R586 T1191 T1189 case 's,huntingtin
R587 T1192 T1190 amod essential,activities
R588 T1193 T1188 prep by,discover
R589 T1194 T1193 pcomp studying,by
R590 T1195 T1196 det the,effects
R591 T1196 T1194 dobj effects,studying
R592 T1197 T1196 prep of,effects
R593 T1198 T1199 compound huntingtin,deficiency
R594 T1199 T1197 pobj deficiency,of
R595 T1200 T1194 prep in,studying
R596 T1201 T1202 det the,mouse
R597 T1202 T1200 pobj mouse,in
R598 T1203 T1179 punct .,set
R599 T1205 T1206 nsubj Inactivation,shown
R600 T1207 T1205 prep of,Inactivation
R601 T1208 T1209 det the,gene
R602 T1209 T1207 pobj gene,of
R603 T1210 T1209 compound mouse,gene
R604 T1211 T1209 compound HD,gene
R605 T1212 T1209 punct (,gene
R606 T1213 T1209 appos Hdh,gene
R607 T1214 T1206 punct ),shown
R608 T1215 T1206 aux has,shown
R609 T1216 T1217 mark that,required
R610 T1217 T1206 ccomp required,shown
R611 T1218 T1217 nsubjpass huntingtin,required
R612 T1219 T1217 auxpass is,required
R613 T1220 T1217 neg not,required
R614 T1221 T1217 prep for,required
R615 T1222 T1223 compound cell,viability
R616 T1223 T1221 pobj viability,for
R617 T1224 T1217 punct ", ",required
R618 T1225 T1226 mark as,evidenced
R619 T1226 T1217 advcl evidenced,required
R620 T1227 T1226 agent by,evidenced
R621 T1228 T1229 det the,survival
R622 T1229 T1227 pobj survival,by
R623 T1230 T1229 prep of,survival
R624 T1231 T1232 nmod mouse,cells
R625 T1232 T1230 pobj cells,of
R626 T1233 T1232 amod embryonic,cells
R627 T1234 T1232 compound stem,cells
R628 T1235 T1232 cc and,cells
R629 T1236 T1232 conj neurons,cells
R630 T1237 T1238 dep that,lack
R631 T1238 T1236 relcl lack,neurons
R632 T1239 T1238 dobj huntingtin,lack
R633 T1240 T1241 punct [,10
R634 T1241 T1226 parataxis 10,evidenced
R635 T1242 T1243 punct -,12
R636 T1243 T1241 prep 12,10
R637 T1244 T1241 punct ],10
R638 T1245 T1206 punct .,shown
R639 T1247 T1248 advmod However,needed
R640 T1249 T1248 punct ", ",needed
R641 T1250 T1248 nsubjpass huntingtin,needed
R642 T1251 T1248 auxpass is,needed
R643 T1252 T1248 prep at,needed
R644 T1253 T1254 det the,level
R645 T1254 T1252 pobj level,at
R646 T1255 T1254 prep of,level
R647 T1256 T1257 det the,organism
R648 T1257 T1255 pobj organism,of
R649 T1258 T1248 prep for,needed
R650 T1259 T1260 amod proper,development
R651 T1260 T1258 pobj development,for
R652 T1261 T1260 amod mammalian,development
R653 T1262 T1260 amod embryonic,development
R654 T1263 T1264 punct [,14
R655 T1264 T1248 parataxis 14,needed
R656 T1265 T1264 nummod 10,14
R657 T1266 T1264 punct ",",14
R658 T1267 T1264 nummod 13,14
R659 T1268 T1264 punct ",",14
R660 T1269 T1264 punct ],14
R661 T1270 T1248 punct .,needed
R662 T1272 T1273 amod Complete,lack
R663 T1273 T1274 nsubj lack,results
R664 T1275 T1273 prep of,lack
R665 T1276 T1275 pobj huntingtin,of
R666 T1277 T1274 prep in,results
R667 T1278 T1279 amod developmental,arrest
R668 T1279 T1277 pobj arrest,in
R669 T1280 T1274 prep during,results
R670 T1281 T1280 pobj gastrulation,during
R671 T1282 T1274 punct ", ",results
R672 T1283 T1284 mark while,results
R673 T1284 T1274 advcl results,results
R674 T1285 T1286 amod severe,reduction
R675 T1286 T1284 nsubj reduction,results
R676 T1287 T1286 prep of,reduction
R677 T1288 T1289 compound huntingtin,levels
R678 T1289 T1287 pobj levels,of
R679 T1290 T1284 prep in,results
R680 T1291 T1292 amod abnormal,neurogenesis
R681 T1292 T1290 pobj neurogenesis,in
R682 T1293 T1292 cc and,neurogenesis
R683 T1294 T1295 amod perinatal,lethality
R684 T1295 T1292 conj lethality,neurogenesis
R685 T1296 T1297 punct [,15
R686 T1297 T1284 parataxis 15,results
R687 T1298 T1297 punct ],15
R688 T1299 T1274 punct .,results