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PMC:1208873 / 18336-19684 JSONTXT 4 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T4754 0-8 JJ denotes Previous
T4755 9-16 NNS denotes studies
T4757 17-19 IN denotes of
T4758 20-28 JJ denotes chimeric
T4759 29-36 NNS denotes embryos
T4756 37-44 VBP denotes suggest
T4760 45-49 IN denotes that
T4762 50-60 NN denotes huntingtin
T4763 61-63 VBZ denotes is
T4761 64-72 VBN denotes required
T4764 73-77 RB denotes only
T4765 78-80 IN denotes in
T4766 81-84 DT denotes the
T4768 85-99 JJ denotes extraembryonic
T4767 100-106 NN denotes tissue
T4769 107-110 IN denotes for
T4770 111-117 JJ denotes proper
T4771 118-129 NN denotes development
T4772 130-131 -LRB- denotes [
T4773 131-133 CD denotes 16
T4774 133-134 -RRB- denotes ]
T4775 134-135 . denotes .
T4776 135-259 sentence denotes Signals from the extraembryonic tissue are critical for the induction of embryonic signals and for patterning the epiblast.
T4777 136-143 NNS denotes Signals
T4779 144-148 IN denotes from
T4780 149-152 DT denotes the
T4782 153-167 JJ denotes extraembryonic
T4781 168-174 NN denotes tissue
T4778 175-178 VBP denotes are
T4783 179-187 JJ denotes critical
T4784 188-191 IN denotes for
T4785 192-195 DT denotes the
T4786 196-205 NN denotes induction
T4787 206-208 IN denotes of
T4788 209-218 JJ denotes embryonic
T4789 219-226 NNS denotes signals
T4790 227-230 CC denotes and
T4791 231-234 IN denotes for
T4792 235-245 VBG denotes patterning
T4793 246-249 DT denotes the
T4794 250-258 NN denotes epiblast
T4795 258-259 . denotes .
T4796 259-345 sentence denotes Consequently, we examined extraembryonic development in huntingtin deficient embryos.
T4797 260-272 RB denotes Consequently
T4799 272-274 , denotes ,
T4800 274-276 PRP denotes we
T4798 277-285 VBD denotes examined
T4801 286-300 JJ denotes extraembryonic
T4802 301-312 NN denotes development
T4803 313-315 IN denotes in
T4804 316-326 NN denotes huntingtin
T4805 327-336 JJ denotes deficient
T4806 337-344 NNS denotes embryos
T4807 344-345 . denotes .
T4808 345-573 sentence denotes Hnf4 is a transcription factor expressed in the primitive endoderm as soon as this tissue becomes distinct and is a key regulator of visceral endoderm secreted factors such as alphafetoprotein, apolipoproteins, and transferrin.
T4809 346-350 NN denotes Hnf4
T4810 351-353 VBZ denotes is
T4811 354-355 DT denotes a
T4813 356-369 NN denotes transcription
T4812 370-376 NN denotes factor
T4814 377-386 VBN denotes expressed
T4815 387-389 IN denotes in
T4816 390-393 DT denotes the
T4818 394-403 JJ denotes primitive
T4817 404-412 NN denotes endoderm
T4819 413-415 RB denotes as
T4820 416-420 RB denotes soon
T4821 421-423 IN denotes as
T4823 424-428 DT denotes this
T4824 429-435 NN denotes tissue
T4822 436-443 VBZ denotes becomes
T4825 444-452 JJ denotes distinct
T4826 453-456 CC denotes and
T4827 457-459 VBZ denotes is
T4828 460-461 DT denotes a
T4830 462-465 JJ denotes key
T4829 466-475 NN denotes regulator
T4831 476-478 IN denotes of
T4832 479-487 JJ denotes visceral
T4833 488-496 NN denotes endoderm
T4834 497-505 VBN denotes secreted
T4835 506-513 NNS denotes factors
T4836 514-518 JJ denotes such
T4837 519-521 IN denotes as
T4838 522-538 NN denotes alphafetoprotein
T4839 538-540 , denotes ,
T4840 540-555 NNS denotes apolipoproteins
T4841 555-557 , denotes ,
T4842 557-560 CC denotes and
T4843 561-572 NN denotes transferrin
T4844 572-573 . denotes .
T4845 573-636 sentence denotes Inactivation of Hnf4 results in impaired gastrulation [33,34].
T4846 574-586 NN denotes Inactivation
T4848 587-589 IN denotes of
T4849 590-594 NN denotes Hnf4
T4847 595-602 VBZ denotes results
T4850 603-605 IN denotes in
T4851 606-614 VBN denotes impaired
T4852 615-627 NN denotes gastrulation
T4853 628-629 -LRB- denotes [
T4855 629-631 CD denotes 33
T4856 631-632 , denotes ,
T4854 632-634 CD denotes 34
T4857 634-635 -RRB- denotes ]
T4858 635-636 . denotes .
T4859 636-760 sentence denotes At E7.5, Hnf4 is expressed in the columnar visceral endoderm cells at the extraembryonic-ectoderm junction (Fig. 4A, [33]).
T4860 637-639 IN denotes At
T4862 640-644 NN denotes E7.5
T4863 644-646 , denotes ,
T4864 646-650 NN denotes Hnf4
T4865 651-653 VBZ denotes is
T4861 654-663 VBN denotes expressed
T4866 664-666 IN denotes in
T4867 667-670 DT denotes the
T4869 671-679 JJ denotes columnar
T4871 680-688 JJ denotes visceral
T4870 689-697 NN denotes endoderm
T4868 698-703 NNS denotes cells
T4872 704-706 IN denotes at
T4873 707-710 DT denotes the
T4875 711-725 JJ denotes extraembryonic
T4877 725-726 HYPH denotes -
T4876 726-734 NN denotes ectoderm
T4874 735-743 NN denotes junction
T4878 744-745 -LRB- denotes (
T4880 745-749 NN denotes Fig.
T4881 750-752 CD denotes 4A
T4882 752-754 , denotes ,
T4883 754-755 -LRB- denotes [
T4879 755-757 CD denotes 33
T4884 757-758 -RRB- denotes ]
T4885 758-759 -RRB- denotes )
T4886 759-760 . denotes .
T4887 760-985 sentence denotes In Hdhex4/5/Hdhex4/5 embryos, consistent with normal primitive and visceral endoderm differentiation, Hnf4 expression appears normal, although the signal is stronger in mutant embryos compared to wild-type embryos (Fig. 4B).
T4888 761-763 IN denotes In
T4890 764-770 NN denotes Hdhex4
T4892 770-771 HYPH denotes /
T4893 771-772 CD denotes 5
T4894 772-773 HYPH denotes /
T4895 773-779 NN denotes Hdhex4
T4896 779-780 HYPH denotes /
T4897 780-781 CD denotes 5
T4891 782-789 NNS denotes embryos
T4898 789-791 , denotes ,
T4899 791-801 JJ denotes consistent
T4900 802-806 IN denotes with
T4901 807-813 JJ denotes normal
T4903 814-823 JJ denotes primitive
T4904 824-827 CC denotes and
T4905 828-836 JJ denotes visceral
T4906 837-845 NN denotes endoderm
T4902 846-861 NN denotes differentiation
T4907 861-863 , denotes ,
T4908 863-867 NN denotes Hnf4
T4909 868-878 NN denotes expression
T4889 879-886 VBZ denotes appears
T4910 887-893 JJ denotes normal
T4911 893-895 , denotes ,
T4912 895-903 IN denotes although
T4914 904-907 DT denotes the
T4915 908-914 NN denotes signal
T4913 915-917 VBZ denotes is
T4916 918-926 JJR denotes stronger
T4917 927-929 IN denotes in
T4918 930-936 NN denotes mutant
T4919 937-944 NNS denotes embryos
T4920 945-953 VBN denotes compared
T4921 954-956 IN denotes to
T4922 957-961 JJ denotes wild
T4924 961-962 HYPH denotes -
T4923 962-966 NN denotes type
T4925 967-974 NNS denotes embryos
T4926 975-976 -LRB- denotes (
T4927 976-980 NN denotes Fig.
T4928 981-983 CD denotes 4B
T4929 983-984 -RRB- denotes )
T4930 984-985 . denotes .
T4931 985-1191 sentence denotes Similarly, Pem, a transcription factor expressed in proximal visceral endoderm and ectoplacental cone in wild-type embryos at E7.5, also is expressed in these tissues in the mutant embryos (Fig. 4C,D[35]).
T4932 986-995 RB denotes Similarly
T4934 995-997 , denotes ,
T4935 997-1000 NN denotes Pem
T4936 1000-1002 , denotes ,
T4937 1002-1003 DT denotes a
T4939 1004-1017 NN denotes transcription
T4938 1018-1024 NN denotes factor
T4940 1025-1034 VBN denotes expressed
T4941 1035-1037 IN denotes in
T4942 1038-1046 JJ denotes proximal
T4944 1047-1055 JJ denotes visceral
T4943 1056-1064 NN denotes endoderm
T4945 1065-1068 CC denotes and
T4946 1069-1082 JJ denotes ectoplacental
T4947 1083-1087 NN denotes cone
T4948 1088-1090 IN denotes in
T4949 1091-1095 JJ denotes wild
T4951 1095-1096 HYPH denotes -
T4950 1096-1100 NN denotes type
T4952 1101-1108 NNS denotes embryos
T4953 1109-1111 IN denotes at
T4954 1112-1116 NN denotes E7.5
T4955 1116-1118 , denotes ,
T4956 1118-1122 RB denotes also
T4957 1123-1125 VBZ denotes is
T4933 1126-1135 VBN denotes expressed
T4958 1136-1138 IN denotes in
T4959 1139-1144 DT denotes these
T4960 1145-1152 NNS denotes tissues
T4961 1153-1155 IN denotes in
T4962 1156-1159 DT denotes the
T4964 1160-1166 NN denotes mutant
T4963 1167-1174 NNS denotes embryos
T4965 1175-1176 -LRB- denotes (
T4967 1176-1180 NNP denotes Fig.
T4969 1181-1183 CD denotes 4C
T4970 1183-1184 , denotes ,
T4968 1184-1185 NN denotes D
T4971 1185-1186 -LRB- denotes [
T4966 1186-1188 CD denotes 35
T4972 1188-1189 -RRB- denotes ]
T4973 1189-1190 -RRB- denotes )
T4974 1190-1191 . denotes .
T4975 1191-1348 sentence denotes However, Pem expressing visceral endoderm hangs over the anterior of the mutant embryos, revealing abnormal location despite grossly normal differentiation.
T4976 1192-1199 RB denotes However
T4978 1199-1201 , denotes ,
T4979 1201-1204 NN denotes Pem
T4980 1205-1215 VBG denotes expressing
T4981 1216-1224 JJ denotes visceral
T4982 1225-1233 NN denotes endoderm
T4977 1234-1239 VBZ denotes hangs
T4983 1240-1244 IN denotes over
T4984 1245-1248 DT denotes the
T4985 1249-1257 NN denotes anterior
T4986 1258-1260 IN denotes of
T4987 1261-1264 DT denotes the
T4989 1265-1271 NN denotes mutant
T4988 1272-1279 NNS denotes embryos
T4990 1279-1281 , denotes ,
T4991 1281-1290 VBG denotes revealing
T4992 1291-1299 JJ denotes abnormal
T4993 1300-1308 NN denotes location
T4994 1309-1316 IN denotes despite
T4995 1317-1324 RB denotes grossly
T4996 1325-1331 JJ denotes normal
T4997 1332-1347 NN denotes differentiation
T4998 1347-1348 . denotes .
R2607 T4754 T4755 amod Previous,studies
R2608 T4755 T4756 nsubj studies,suggest
R2609 T4757 T4755 prep of,studies
R2610 T4758 T4759 amod chimeric,embryos
R2611 T4759 T4757 pobj embryos,of
R2612 T4760 T4761 mark that,required
R2613 T4761 T4756 ccomp required,suggest
R2614 T4762 T4761 nsubjpass huntingtin,required
R2615 T4763 T4761 auxpass is,required
R2616 T4764 T4765 advmod only,in
R2617 T4765 T4761 prep in,required
R2618 T4766 T4767 det the,tissue
R2619 T4767 T4765 pobj tissue,in
R2620 T4768 T4767 amod extraembryonic,tissue
R2621 T4769 T4761 prep for,required
R2622 T4770 T4771 amod proper,development
R2623 T4771 T4769 pobj development,for
R2624 T4772 T4773 punct [,16
R2625 T4773 T4761 parataxis 16,required
R2626 T4774 T4773 punct ],16
R2627 T4775 T4756 punct .,suggest
R2628 T4777 T4778 nsubj Signals,are
R2629 T4779 T4777 prep from,Signals
R2630 T4780 T4781 det the,tissue
R2631 T4781 T4779 pobj tissue,from
R2632 T4782 T4781 amod extraembryonic,tissue
R2633 T4783 T4778 acomp critical,are
R2634 T4784 T4783 prep for,critical
R2635 T4785 T4786 det the,induction
R2636 T4786 T4784 pobj induction,for
R2637 T4787 T4786 prep of,induction
R2638 T4788 T4789 amod embryonic,signals
R2639 T4789 T4787 pobj signals,of
R2640 T4790 T4784 cc and,for
R2641 T4791 T4784 conj for,for
R2642 T4792 T4791 pcomp patterning,for
R2643 T4793 T4794 det the,epiblast
R2644 T4794 T4792 dobj epiblast,patterning
R2645 T4795 T4778 punct .,are
R2646 T4797 T4798 advmod Consequently,examined
R2647 T4799 T4798 punct ", ",examined
R2648 T4800 T4798 nsubj we,examined
R2649 T4801 T4802 amod extraembryonic,development
R2650 T4802 T4798 dobj development,examined
R2651 T4803 T4798 prep in,examined
R2652 T4804 T4805 npadvmod huntingtin,deficient
R2653 T4805 T4806 amod deficient,embryos
R2654 T4806 T4803 pobj embryos,in
R2655 T4807 T4798 punct .,examined
R2656 T4809 T4810 nsubj Hnf4,is
R2657 T4811 T4812 det a,factor
R2658 T4812 T4810 attr factor,is
R2659 T4813 T4812 compound transcription,factor
R2660 T4814 T4812 acl expressed,factor
R2661 T4815 T4814 prep in,expressed
R2662 T4816 T4817 det the,endoderm
R2663 T4817 T4815 pobj endoderm,in
R2664 T4818 T4817 amod primitive,endoderm
R2665 T4819 T4820 advmod as,soon
R2666 T4820 T4814 advmod soon,expressed
R2667 T4821 T4822 mark as,becomes
R2668 T4822 T4820 advcl becomes,soon
R2669 T4823 T4824 det this,tissue
R2670 T4824 T4822 nsubj tissue,becomes
R2671 T4825 T4822 acomp distinct,becomes
R2672 T4826 T4822 cc and,becomes
R2673 T4827 T4822 conj is,becomes
R2674 T4828 T4829 det a,regulator
R2675 T4829 T4827 attr regulator,is
R2676 T4830 T4829 amod key,regulator
R2677 T4831 T4829 prep of,regulator
R2678 T4832 T4833 amod visceral,endoderm
R2679 T4833 T4834 npadvmod endoderm,secreted
R2680 T4834 T4835 amod secreted,factors
R2681 T4835 T4831 pobj factors,of
R2682 T4836 T4837 amod such,as
R2683 T4837 T4835 prep as,factors
R2684 T4838 T4837 pobj alphafetoprotein,as
R2685 T4839 T4838 punct ", ",alphafetoprotein
R2686 T4840 T4838 conj apolipoproteins,alphafetoprotein
R2687 T4841 T4840 punct ", ",apolipoproteins
R2688 T4842 T4840 cc and,apolipoproteins
R2689 T4843 T4840 conj transferrin,apolipoproteins
R2690 T4844 T4810 punct .,is
R2691 T4846 T4847 nsubj Inactivation,results
R2692 T4848 T4846 prep of,Inactivation
R2693 T4849 T4848 pobj Hnf4,of
R2694 T4850 T4847 prep in,results
R2695 T4851 T4852 amod impaired,gastrulation
R2696 T4852 T4850 pobj gastrulation,in
R2697 T4853 T4854 punct [,34
R2698 T4854 T4847 parataxis 34,results
R2699 T4855 T4854 nummod 33,34
R2700 T4856 T4854 punct ",",34
R2701 T4857 T4854 punct ],34
R2702 T4858 T4847 punct .,results
R2703 T4860 T4861 prep At,expressed
R2704 T4862 T4860 pobj E7.5,At
R2705 T4863 T4861 punct ", ",expressed
R2706 T4864 T4861 nsubjpass Hnf4,expressed
R2707 T4865 T4861 auxpass is,expressed
R2708 T4866 T4861 prep in,expressed
R2709 T4867 T4868 det the,cells
R2710 T4868 T4866 pobj cells,in
R2711 T4869 T4870 amod columnar,endoderm
R2712 T4870 T4868 compound endoderm,cells
R2713 T4871 T4870 amod visceral,endoderm
R2714 T4872 T4861 prep at,expressed
R2715 T4873 T4874 det the,junction
R2716 T4874 T4872 pobj junction,at
R2717 T4875 T4876 amod extraembryonic,ectoderm
R2718 T4876 T4874 compound ectoderm,junction
R2719 T4877 T4876 punct -,ectoderm
R2720 T4878 T4879 punct (,33
R2721 T4879 T4861 parataxis 33,expressed
R2722 T4880 T4879 dep Fig.,33
R2723 T4881 T4880 nummod 4A,Fig.
R2724 T4882 T4879 punct ", ",33
R2725 T4883 T4879 punct [,33
R2726 T4884 T4879 punct ],33
R2727 T4885 T4879 punct ),33
R2728 T4886 T4861 punct .,expressed
R2729 T4888 T4889 prep In,appears
R2730 T4890 T4891 nmod Hdhex4,embryos
R2731 T4891 T4888 pobj embryos,In
R2732 T4892 T4890 punct /,Hdhex4
R2733 T4893 T4890 nummod 5,Hdhex4
R2734 T4894 T4890 punct /,Hdhex4
R2735 T4895 T4890 appos Hdhex4,Hdhex4
R2736 T4896 T4895 punct /,Hdhex4
R2737 T4897 T4895 nummod 5,Hdhex4
R2738 T4898 T4889 punct ", ",appears
R2739 T4899 T4889 advcl consistent,appears
R2740 T4900 T4899 prep with,consistent
R2741 T4901 T4902 amod normal,differentiation
R2742 T4902 T4900 pobj differentiation,with
R2743 T4903 T4902 amod primitive,differentiation
R2744 T4904 T4903 cc and,primitive
R2745 T4905 T4903 conj visceral,primitive
R2746 T4906 T4902 compound endoderm,differentiation
R2747 T4907 T4889 punct ", ",appears
R2748 T4908 T4909 compound Hnf4,expression
R2749 T4909 T4889 nsubj expression,appears
R2750 T4910 T4889 oprd normal,appears
R2751 T4911 T4889 punct ", ",appears
R2752 T4912 T4913 mark although,is
R2753 T4913 T4889 advcl is,appears
R2754 T4914 T4915 det the,signal
R2755 T4915 T4913 nsubj signal,is
R2756 T4916 T4913 acomp stronger,is
R2757 T4917 T4913 prep in,is
R2758 T4918 T4919 compound mutant,embryos
R2759 T4919 T4917 pobj embryos,in
R2760 T4920 T4913 prep compared,is
R2761 T4921 T4920 prep to,compared
R2762 T4922 T4923 amod wild,type
R2763 T4923 T4925 compound type,embryos
R2764 T4924 T4923 punct -,type
R2765 T4925 T4921 pobj embryos,to
R2766 T4926 T4927 punct (,Fig.
R2767 T4927 T4889 parataxis Fig.,appears
R2768 T4928 T4927 nummod 4B,Fig.
R2769 T4929 T4927 punct ),Fig.
R2770 T4930 T4889 punct .,appears
R2771 T4932 T4933 advmod Similarly,expressed
R2772 T4934 T4933 punct ", ",expressed
R2773 T4935 T4933 nsubjpass Pem,expressed
R2774 T4936 T4935 punct ", ",Pem
R2775 T4937 T4938 det a,factor
R2776 T4938 T4935 appos factor,Pem
R2777 T4939 T4938 compound transcription,factor
R2778 T4940 T4938 acl expressed,factor
R2779 T4941 T4940 prep in,expressed
R2780 T4942 T4943 amod proximal,endoderm
R2781 T4943 T4941 pobj endoderm,in
R2782 T4944 T4943 amod visceral,endoderm
R2783 T4945 T4943 cc and,endoderm
R2784 T4946 T4947 amod ectoplacental,cone
R2785 T4947 T4943 conj cone,endoderm
R2786 T4948 T4940 prep in,expressed
R2787 T4949 T4950 amod wild,type
R2788 T4950 T4952 compound type,embryos
R2789 T4951 T4950 punct -,type
R2790 T4952 T4948 pobj embryos,in
R2791 T4953 T4940 prep at,expressed
R2792 T4954 T4953 pobj E7.5,at
R2793 T4955 T4933 punct ", ",expressed
R2794 T4956 T4933 advmod also,expressed
R2795 T4957 T4933 auxpass is,expressed
R2796 T4958 T4933 prep in,expressed
R2797 T4959 T4960 det these,tissues
R2798 T4960 T4958 pobj tissues,in
R2799 T4961 T4933 prep in,expressed
R2800 T4962 T4963 det the,embryos
R2801 T4963 T4961 pobj embryos,in
R2802 T4964 T4963 compound mutant,embryos
R2803 T4965 T4966 punct (,35
R2804 T4966 T4933 parataxis 35,expressed
R2805 T4967 T4968 nmod Fig.,D
R2806 T4968 T4966 dep D,35
R2807 T4969 T4968 nummod 4C,D
R2808 T4970 T4968 punct ",",D
R2809 T4971 T4966 punct [,35
R2810 T4972 T4966 punct ],35
R2811 T4973 T4966 punct ),35
R2812 T4974 T4933 punct .,expressed
R2813 T4976 T4977 advmod However,hangs
R2814 T4978 T4977 punct ", ",hangs
R2815 T4979 T4977 nsubj Pem,hangs
R2816 T4980 T4979 acl expressing,Pem
R2817 T4981 T4982 amod visceral,endoderm
R2818 T4982 T4980 dobj endoderm,expressing
R2819 T4983 T4977 prep over,hangs
R2820 T4984 T4985 det the,anterior
R2821 T4985 T4983 pobj anterior,over
R2822 T4986 T4985 prep of,anterior
R2823 T4987 T4988 det the,embryos
R2824 T4988 T4986 pobj embryos,of
R2825 T4989 T4988 compound mutant,embryos
R2826 T4990 T4977 punct ", ",hangs
R2827 T4991 T4977 advcl revealing,hangs
R2828 T4992 T4993 amod abnormal,location
R2829 T4993 T4991 dobj location,revealing
R2830 T4994 T4991 prep despite,revealing
R2831 T4995 T4996 advmod grossly,normal
R2832 T4996 T4997 amod normal,differentiation
R2833 T4997 T4994 pobj differentiation,despite
R2834 T4998 T4977 punct .,hangs