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PMC:1189073 / 4617-5615 JSONTXT 5 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T2764 0-7 VBG denotes leading
T2765 8-10 IN denotes to
T2766 11-12 DT denotes a
T2767 13-17 NN denotes rise
T2768 18-20 IN denotes in
T2769 21-34 JJ denotes intracellular
T2770 35-39 NN denotes cAMP
T2771 39-41 , denotes ,
T2772 41-51 RB denotes ultimately
T2773 52-61 VBG denotes resulting
T2774 62-64 IN denotes in
T2775 65-80 NN denotes phosphorylation
T2776 81-83 IN denotes of
T2777 84-88 NN denotes AQP2
T2778 89-91 IN denotes at
T2779 92-98 NN denotes serine
T2780 99-102 CD denotes 256
T2781 103-105 IN denotes by
T2782 106-110 NN denotes cAMP
T2784 110-111 HYPH denotes -
T2783 111-120 JJ denotes dependent
T2786 121-128 NN denotes protein
T2785 129-135 NN denotes kinase
T2787 136-137 -LRB- denotes [
T2788 137-138 CD denotes 9
T2789 138-139 -RRB- denotes ]
T2790 140-143 CC denotes and
T2791 144-147 PRP$ denotes its
T2792 148-162 NN denotes redistribution
T2793 163-165 IN denotes to
T2794 166-169 DT denotes the
T2796 170-176 NN denotes plasma
T2795 177-185 NN denotes membrane
T2797 185-186 . denotes .
T2798 186-336 sentence denotes The importance of AQP2 redistribution has been highlighted by functional characterization of Aqp2 mutations resulting in severe NDI in humans [3,10].
T2799 187-190 DT denotes The
T2800 191-201 NN denotes importance
T2802 202-204 IN denotes of
T2803 205-209 NN denotes AQP2
T2804 210-224 NN denotes redistribution
T2805 225-228 VBZ denotes has
T2806 229-233 VBN denotes been
T2801 234-245 VBN denotes highlighted
T2807 246-248 IN denotes by
T2808 249-259 JJ denotes functional
T2809 260-276 NN denotes characterization
T2810 277-279 IN denotes of
T2811 280-284 NN denotes Aqp2
T2812 285-294 NNS denotes mutations
T2813 295-304 VBG denotes resulting
T2814 305-307 IN denotes in
T2815 308-314 JJ denotes severe
T2816 315-318 NN denotes NDI
T2817 319-321 IN denotes in
T2818 322-328 NNS denotes humans
T2819 329-330 -LRB- denotes [
T2821 330-331 CD denotes 3
T2822 331-332 , denotes ,
T2820 332-334 CD denotes 10
T2823 334-335 -RRB- denotes ]
T2824 335-336 . denotes .
T2825 336-519 sentence denotes Recessive Aqp2 mutations are generally thought to produce an abnormally localized and, in most instances, misfolded water pore that responds abnormally to an increase in cAMP [6,11].
T2826 337-346 JJ denotes Recessive
T2828 347-351 NN denotes Aqp2
T2827 352-361 NNS denotes mutations
T2830 362-365 VBP denotes are
T2831 366-375 RB denotes generally
T2829 376-383 VBN denotes thought
T2832 384-386 TO denotes to
T2833 387-394 VB denotes produce
T2834 395-397 DT denotes an
T2836 398-408 RB denotes abnormally
T2837 409-418 VBN denotes localized
T2838 419-422 CC denotes and
T2839 422-424 , denotes ,
T2841 424-426 IN denotes in
T2842 427-431 JJS denotes most
T2843 432-441 NNS denotes instances
T2844 441-443 , denotes ,
T2840 443-452 VBN denotes misfolded
T2845 453-458 NN denotes water
T2835 459-463 NN denotes pore
T2846 464-468 WDT denotes that
T2847 469-477 VBZ denotes responds
T2848 478-488 RB denotes abnormally
T2849 489-491 IN denotes to
T2850 492-494 DT denotes an
T2851 495-503 NN denotes increase
T2852 504-506 IN denotes in
T2853 507-511 NN denotes cAMP
T2854 512-513 -LRB- denotes [
T2856 513-514 CD denotes 6
T2857 514-515 , denotes ,
T2855 515-517 CD denotes 11
T2858 517-518 -RRB- denotes ]
T2859 518-519 . denotes .
T2860 519-671 sentence denotes Furthermore, dominant mutations have been described and found to misroute both the mutant and the wild-type protein to the basolateral membrane [6,12].
T2861 520-531 RB denotes Furthermore
T2863 531-533 , denotes ,
T2864 533-541 JJ denotes dominant
T2865 542-551 NNS denotes mutations
T2866 552-556 VBP denotes have
T2867 557-561 VBN denotes been
T2862 562-571 VBN denotes described
T2868 572-575 CC denotes and
T2869 576-581 VBN denotes found
T2870 582-584 TO denotes to
T2871 585-593 VB denotes misroute
T2872 594-598 CC denotes both
T2874 599-602 DT denotes the
T2873 603-609 NN denotes mutant
T2875 610-613 CC denotes and
T2876 614-617 DT denotes the
T2878 618-622 JJ denotes wild
T2879 622-623 HYPH denotes -
T2877 623-627 NN denotes type
T2880 628-635 NN denotes protein
T2881 636-638 IN denotes to
T2882 639-642 DT denotes the
T2884 643-654 JJ denotes basolateral
T2883 655-663 NN denotes membrane
T2885 664-665 -LRB- denotes [
T2887 665-666 CD denotes 6
T2888 666-667 , denotes ,
T2886 667-669 CD denotes 12
T2889 669-670 -RRB- denotes ]
T2890 670-671 . denotes .
T2891 671-743 sentence denotes Several mouse models of diabetes insipidus have been generated [13–17].
T2892 672-679 JJ denotes Several
T2894 680-685 NN denotes mouse
T2893 686-692 NNS denotes models
T2896 693-695 IN denotes of
T2897 696-704 NN denotes diabetes
T2898 705-714 NN denotes insipidus
T2899 715-719 VBP denotes have
T2900 720-724 VBN denotes been
T2895 725-734 VBN denotes generated
T2901 735-736 -LRB- denotes [
T2902 736-738 CD denotes 13
T2903 738-739 SYM denotes –
T2904 739-741 CD denotes 17
T2905 741-742 -RRB- denotes ]
T2906 742-743 . denotes .
T2907 743-851 sentence denotes In an attempt to recapitulate human NDI, mice have been generated with mutations in Aqp2 and Avpr2 [15,18].
T2908 744-746 IN denotes In
T2910 747-749 DT denotes an
T2911 750-757 NN denotes attempt
T2912 758-760 TO denotes to
T2913 761-773 VB denotes recapitulate
T2914 774-779 JJ denotes human
T2915 780-783 NN denotes NDI
T2916 783-785 , denotes ,
T2917 785-789 NNS denotes mice
T2918 790-794 VBP denotes have
T2919 795-799 VBN denotes been
T2909 800-809 VBN denotes generated
T2920 810-814 IN denotes with
T2921 815-824 NNS denotes mutations
T2922 825-827 IN denotes in
T2923 828-832 NN denotes Aqp2
T2924 833-836 CC denotes and
T2925 837-842 NN denotes Avpr2
T2926 843-844 -LRB- denotes [
T2928 844-846 CD denotes 15
T2929 846-847 , denotes ,
T2927 847-849 CD denotes 18
T2930 849-850 -RRB- denotes ]
T2931 850-851 . denotes .
T2932 851-936 sentence denotes Yang and colleagues created a mouse with a T126M knock-in mutation in the Aqp2 gene.
T2933 852-856 NNP denotes Yang
T2935 857-860 CC denotes and
T2936 861-871 NNS denotes colleagues
T2934 872-879 VBD denotes created
T2937 880-881 DT denotes a
T2938 882-887 NN denotes mouse
T2939 888-892 IN denotes with
T2940 893-894 DT denotes a
T2942 895-900 NN denotes T126M
T2943 901-906 VB denotes knock
T2944 906-907 HYPH denotes -
T2945 907-909 RP denotes in
T2941 910-918 NN denotes mutation
T2946 919-921 IN denotes in
T2947 922-925 DT denotes the
T2949 926-930 NN denotes Aqp2
T2948 931-935 NN denotes gene
T2950 935-936 . denotes .
T2952 937-949 RB denotes Unexpectedly
T2954 949-951 , denotes ,
T2955 951-961 JJ denotes homozygous
T2957 962-968 NN denotes mutant
T2956 969-973 NNS denotes mice
T2953 974-978 VBD denotes died
T2958 979-985 IN denotes within
T2959 986-987 CD denotes 6
T2960 988-989 NNS denotes d
T2961 990-995 IN denotes after
R538 T2765 T2764 prep to,leading
R539 T2766 T2767 det a,rise
R540 T2767 T2765 pobj rise,to
R541 T2768 T2767 prep in,rise
R542 T2769 T2770 amod intracellular,cAMP
R543 T2770 T2768 pobj cAMP,in
R544 T2771 T2764 punct ", ",leading
R545 T2772 T2773 advmod ultimately,resulting
R546 T2773 T2764 advcl resulting,leading
R547 T2774 T2773 prep in,resulting
R548 T2775 T2774 pobj phosphorylation,in
R549 T2776 T2775 prep of,phosphorylation
R550 T2777 T2776 pobj AQP2,of
R551 T2778 T2775 prep at,phosphorylation
R552 T2779 T2778 pobj serine,at
R553 T2780 T2779 nummod 256,serine
R554 T2781 T2775 prep by,phosphorylation
R555 T2782 T2783 npadvmod cAMP,dependent
R556 T2783 T2785 amod dependent,kinase
R557 T2784 T2783 punct -,dependent
R558 T2785 T2781 pobj kinase,by
R559 T2786 T2785 compound protein,kinase
R560 T2787 T2788 punct [,9
R561 T2788 T2775 parataxis 9,phosphorylation
R562 T2789 T2788 punct ],9
R563 T2790 T2775 cc and,phosphorylation
R564 T2791 T2792 poss its,redistribution
R565 T2792 T2775 conj redistribution,phosphorylation
R566 T2793 T2792 prep to,redistribution
R567 T2794 T2795 det the,membrane
R568 T2795 T2793 pobj membrane,to
R569 T2796 T2795 compound plasma,membrane
R571 T2799 T2800 det The,importance
R572 T2800 T2801 nsubjpass importance,highlighted
R573 T2802 T2800 prep of,importance
R574 T2803 T2804 compound AQP2,redistribution
R575 T2804 T2802 pobj redistribution,of
R576 T2805 T2801 aux has,highlighted
R577 T2806 T2801 auxpass been,highlighted
R578 T2807 T2801 agent by,highlighted
R579 T2808 T2809 amod functional,characterization
R580 T2809 T2807 pobj characterization,by
R581 T2810 T2809 prep of,characterization
R582 T2811 T2812 compound Aqp2,mutations
R583 T2812 T2810 pobj mutations,of
R584 T2813 T2801 advcl resulting,highlighted
R585 T2814 T2813 prep in,resulting
R586 T2815 T2816 amod severe,NDI
R587 T2816 T2814 pobj NDI,in
R588 T2817 T2813 prep in,resulting
R589 T2818 T2817 pobj humans,in
R590 T2819 T2820 punct [,10
R591 T2820 T2801 parataxis 10,highlighted
R592 T2821 T2820 nummod 3,10
R593 T2822 T2820 punct ",",10
R594 T2823 T2820 punct ],10
R595 T2824 T2801 punct .,highlighted
R596 T2826 T2827 amod Recessive,mutations
R597 T2827 T2829 nsubjpass mutations,thought
R598 T2828 T2827 compound Aqp2,mutations
R599 T2830 T2829 auxpass are,thought
R600 T2831 T2829 advmod generally,thought
R601 T2832 T2833 aux to,produce
R602 T2833 T2829 xcomp produce,thought
R603 T2834 T2835 det an,pore
R604 T2835 T2833 dobj pore,produce
R605 T2836 T2837 advmod abnormally,localized
R606 T2837 T2835 amod localized,pore
R607 T2838 T2837 cc and,localized
R608 T2839 T2840 punct ", ",misfolded
R609 T2840 T2837 conj misfolded,localized
R610 T2841 T2840 prep in,misfolded
R611 T2842 T2843 amod most,instances
R612 T2843 T2841 pobj instances,in
R613 T2844 T2840 punct ", ",misfolded
R614 T2845 T2835 compound water,pore
R615 T2846 T2847 dep that,responds
R616 T2847 T2835 relcl responds,pore
R617 T2848 T2847 advmod abnormally,responds
R618 T2849 T2847 prep to,responds
R619 T2850 T2851 det an,increase
R620 T2851 T2849 pobj increase,to
R621 T2852 T2851 prep in,increase
R622 T2853 T2852 pobj cAMP,in
R623 T2854 T2855 punct [,11
R624 T2855 T2829 parataxis 11,thought
R625 T2856 T2855 nummod 6,11
R626 T2857 T2855 punct ",",11
R627 T2858 T2855 punct ],11
R628 T2859 T2829 punct .,thought
R629 T2861 T2862 advmod Furthermore,described
R630 T2863 T2862 punct ", ",described
R631 T2864 T2865 amod dominant,mutations
R632 T2865 T2862 nsubjpass mutations,described
R633 T2866 T2862 aux have,described
R634 T2867 T2862 auxpass been,described
R635 T2868 T2862 cc and,described
R636 T2869 T2862 conj found,described
R637 T2870 T2871 aux to,misroute
R638 T2871 T2869 xcomp misroute,found
R639 T2872 T2873 preconj both,mutant
R640 T2873 T2871 dobj mutant,misroute
R641 T2874 T2873 det the,mutant
R642 T2875 T2873 cc and,mutant
R643 T2876 T2877 det the,type
R644 T2877 T2880 compound type,protein
R645 T2878 T2877 amod wild,type
R646 T2879 T2877 punct -,type
R647 T2880 T2873 conj protein,mutant
R648 T2881 T2871 prep to,misroute
R649 T2882 T2883 det the,membrane
R650 T2883 T2881 pobj membrane,to
R651 T2884 T2883 amod basolateral,membrane
R652 T2885 T2886 punct [,12
R653 T2886 T2869 parataxis 12,found
R654 T2887 T2886 nummod 6,12
R655 T2888 T2886 punct ",",12
R656 T2889 T2886 punct ],12
R657 T2890 T2862 punct .,described
R658 T2892 T2893 amod Several,models
R659 T2893 T2895 nsubjpass models,generated
R660 T2894 T2893 compound mouse,models
R661 T2896 T2893 prep of,models
R662 T2897 T2898 compound diabetes,insipidus
R663 T2898 T2896 pobj insipidus,of
R664 T2899 T2895 aux have,generated
R665 T2900 T2895 auxpass been,generated
R666 T2901 T2902 punct [,13
R667 T2902 T2895 parataxis 13,generated
R668 T2903 T2904 punct –,17
R669 T2904 T2902 prep 17,13
R670 T2905 T2902 punct ],13
R671 T2906 T2895 punct .,generated
R672 T2908 T2909 prep In,generated
R673 T2910 T2911 det an,attempt
R674 T2911 T2908 pobj attempt,In
R675 T2912 T2913 aux to,recapitulate
R676 T2913 T2911 acl recapitulate,attempt
R677 T2914 T2915 amod human,NDI
R678 T2915 T2913 dobj NDI,recapitulate
R679 T2916 T2909 punct ", ",generated
R680 T2917 T2909 nsubjpass mice,generated
R681 T2918 T2909 aux have,generated
R682 T2919 T2909 auxpass been,generated
R683 T2920 T2909 prep with,generated
R684 T2921 T2920 pobj mutations,with
R685 T2922 T2921 prep in,mutations
R686 T2923 T2922 pobj Aqp2,in
R687 T2924 T2923 cc and,Aqp2
R688 T2925 T2923 conj Avpr2,Aqp2
R689 T2926 T2927 punct [,18
R690 T2927 T2909 parataxis 18,generated
R691 T2928 T2927 nummod 15,18
R692 T2929 T2927 punct ",",18
R693 T2930 T2927 punct ],18
R694 T2931 T2909 punct .,generated
R695 T2933 T2934 nsubj Yang,created
R696 T2935 T2933 cc and,Yang
R697 T2936 T2933 conj colleagues,Yang
R698 T2937 T2938 det a,mouse
R699 T2938 T2934 dobj mouse,created
R700 T2939 T2938 prep with,mouse
R701 T2940 T2941 det a,mutation
R702 T2941 T2939 pobj mutation,with
R703 T2942 T2941 nmod T126M,mutation
R704 T2943 T2941 amod knock,mutation
R705 T2944 T2943 punct -,knock
R706 T2945 T2943 prt in,knock
R707 T2946 T2941 prep in,mutation
R708 T2947 T2948 det the,gene
R709 T2948 T2946 pobj gene,in
R710 T2949 T2948 compound Aqp2,gene
R711 T2950 T2934 punct .,created
R712 T2952 T2953 advmod Unexpectedly,died
R713 T2954 T2953 punct ", ",died
R714 T2955 T2956 amod homozygous,mice
R715 T2956 T2953 nsubj mice,died
R716 T2957 T2956 compound mutant,mice
R717 T2958 T2953 prep within,died
R718 T2959 T2960 nummod 6,d
R719 T2960 T2958 pobj d,within
R720 T2961 T2960 prep after,d